New Findings What is the topic of this review? This manuscript provides a review of the current understanding of the role of the sympathetic nervous system in regulation of the bone marrow‐derived immune cells and their involvement in hypertension. What advances does it highlight? We highlight the recent advances in understanding of the neuro‐immune interactions both peripherally and centrally as they relate to blood pressure control. Abstract The sympathetic nervous system...
Thu Sep 10, 2020 21:23
Publication date: Available online 11 September 2020Source: Journal of the American College of SurgeonsAuthor(s): Koya Yasukawa, Akira Shimizu, Takahide Yokoyama, Koji Kubota, Tsuyoshi Notake, Hitoshi Seki, Akira Kobayashi, Yuji Soejima
Fri Sep 11, 2020 14:14
Abstract Despite considerable knowledge of viral pathogenesis, the pathophysiological changes related to the multifactorial, multistep process of hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC) development remains unclear. Longitudinal metabolomics study can reveal biological process for disease progression. We performed metabolite profiling with longitudinal prediagnostic plasma samples from two nested case‐control studies of hepatitis B surface antigen carriers participating in...
Thu Sep 10, 2020 21:14
Abstract The recent empirical use of hydroxychloroquine in coronavirus disease 2019 (COVID‐19) revived the interest in its cardiac toxicity, increasingly sidelined over time. We aimed to assess and compare the profile of cardiac adverse drug reactions (CADR) associated with hydroxychloroquine before and during COVID‐19. We performed a retrospective comparative observational study using the French Pharmacovigilance network database between 1985 and May 2020 to assess all postmarketing CADR associated...
Thu Sep 10, 2020 19:53
New England Journal of Medicine, Ahead of Print.
Thu Sep 10, 2020 13:05
Abstract Background Even from a young age, modern soccer requires high levels of physical fitness development, particularly jumping and sprinting. Plyometric jump training (PJT), combined with young athletes’ regular soccer sessions, has the potential to improve jumping and sprinting. However, studies exploring the effects of PJT are generally limited by small sample sizes. This problem of underpowered studies may, thus, be resolved...
Fri Sep 11, 2020 03:00
Abstract Background Handgrip strength (HGS) is an excellent marker of functional capability and health in adults, although little is known about temporal trends in adult HGS. Objectives The aim of this study was to systematically analyze national (country-level) temporal trends in adult HGS, and to examine the relationships between national trends...
Fri Sep 11, 2020 03:00
Thu Sep 10, 2020 20:44
Abstract Wolf–Hirschhorn syndrome (WHS) (OMIM#194190) is a contiguous gene syndrome with estimated prevalence being around 1 in 50,000 births. The syndrome is caused by deletion of a critical region (Wolf–Hirschhorn Syndrome Critical region—WHSCR) on chromosome 4p16.3. Its core features are typical facial gestalt, growth retardation, intellectual disability, or developmental delay and seizures. We describe four patients, each highlighting a different aspect of this syndrome. One patient was detected...
Thu Sep 10, 2020 20:38
Abstract Kinase D‐interacting substrate of 220 kDa (KIDINS220) is a transmembrane protein playing integral role in growth mediating pathways in the nervous and cardiovascular systems. KIDINS220 heterozygous truncating variants that affect the protein's C‐terminus have been associated with a phenotype, so far described only in few unrelated children, including spastic paraplegia, intellectual disability, nystagmus, and obesity. More recently, a homozygous, more N‐terminal truncating variant in KIDINS220...
Thu Sep 10, 2020 14:19
Abstract Patients with Down syndrome (DS) often have a high occurrence of obstructive sleep apnea‐hypopnea (OSA) syndrome. We studied a large cohort of adults with DS attended due to clinical suspicion of OSA. A standardized questionnaire and full medical assessment were conducted, including a sleep study. One hundred and fifty‐seven DS individuals were studied, with a mean ± SD age of 36 ± 10 years, 40.7% women, BMI 29.4 ± 5.6 kg/m2. The main clinical symptom was daytime sleepiness (64.9%). A sleep...
Thu Sep 10, 2020 14:09
Abstract Riboflavin transporter deficiency (RTD) (MIM #614707) is a neurogenetic disorder with its most common manifestations including sensorineural hearing loss, peripheral neuropathy, respiratory insufficiency, and bulbar palsy. Here, we present a 2‐year‐old boy whose initial presentation was severe macrocytic anemia necessitating multiple blood transfusions and intermittent neutropenia; he subsequently developed ataxia and dysarthria. Trio‐exome sequencing detected compound heterozygous variants...
Thu Sep 10, 2020 14:08
Abstract Ehlers‐Danlos Syndromes (EDS) and related Hypermobility Spectrum Disorders (HSD) are debilitating connective tissue disorders that feature a prominent pain component for which there are limited therapeutic options for pain management. Consequently, many patients try various non‐prescribed treatments, including complementary and alternative therapies that have not been well studied in the EDS/HSD patient population. We surveyed over 500 individuals through the EDS Society who reported having...
Thu Sep 10, 2020 13:33
Adenoid cystic carcinoma (ACC) of the eyelid is a very rare tumor, and only 11 cases have been previously reported in the literature. Here the authors report the 12th case of eyelid ACC that was initially diagnosed as adenoid basal cell carcinoma. This is the first report of local recurrence after wide local excision using the Mohs technique. Additionally, this is the first report that demonstrates that ACC can present clinically and histologically similar to basal cell carcinoma. The authors summarize...
Tue Sep 01, 2020 03:00
Purpose: To describe 10 patients with Morbihan syndrome, a rare condition characterized by the slow appearance of erythema and solid edema on the upper portion of the face, and review the literature. Methods: Retrospective case series and review. Results: The majority of patients were male (80%), and the mean age at presentation was 67 years (range, 48–88 years); 60% had asymmetrical disease (affecting mainly the right side). All subjects underwent a lid biopsy to support the diagnosis...
Tue Sep 01, 2020 03:00
No abstract available
Tue Sep 01, 2020 03:00
Purpose: To determine if there is a biologic rationale for using checkpoint inhibitor drugs targeting programmed cell death ligand 1 (PD-L1) and PD-L2 in the treatment of adenoid cystic carcinoma of the orbit. Methods: Twenty-three cases of adenoid cystic carcinoma involving the orbit (13 primary lacrimal gland, 5 secondarily extending into the orbit, and 5 unspecified) were examined histopathologically. Immunohistochemistry for PD-L1, PD-L2, and CD8 was performed. Charts were reviewed for...
Tue Sep 01, 2020 03:00
No abstract available
Tue Sep 01, 2020 03:00
Purpose: To describe clinical outcomes of a minimally invasive technique for direct corneal neurotization to treat neurotrophic keratopathy. Methods: All cases of corneal neurotization for neurotrophic keratopathy performed by a single surgeon using minimally invasive direct corneal neurotization were reviewed. The supraorbital donor nerve was directly transferred to the cornea through an upper eyelid crease incision using either a combination of endoscopic and direct visualization or direct...
Tue Sep 01, 2020 03:00
Purpose: To evaluate surgical outcomes of Müller muscle conjunctival resection surgery for reoperation of residual ptosis after external levator advancement in patients with aponeurotic ptosis. Methods: A total of 23 eyes of 23 patients who had undergone Müller muscle conjunctival resection for residual ptosis between January 2016 and July 2018 were reviewed retrospectively. Margin reflex distance (MRD), interlid crease, and show distance measurements were performed with a ruler in millimeters...
Tue Sep 01, 2020 03:00
Orbital actinomyces is a rare diagnosis with only a few cases reported in the literature. It can be difficult to diagnose due to its slow, indolent course, and nonspecific findings on imaging and clinical examination, and frequently it can masquerade as other pathologies such as neoplasm and inflammatory disease. The authors present a case of actinomyces masquerading as meningioma with findings of hyperostosis and a superior orbital roof interosseous tract on imaging.
Tue Sep 01, 2020 03:00
Purpose: To compare the thickness of the retro- and sub-orbicularis oculi fat (ROOF and SOOF) between patients with thyroid eye disease (TED) and controls via MRI and to determine factors influencing fat thickness. Methods: This retrospective, comparative, case-control study included 136 patients (272 sides) with TED and 50 control patients (50 sides). The thickness of the ROOF and SOOF was measured on the quasi-sagittal plane through the optic nerve (the central plane) and 6 mm lateral and...
Tue Sep 01, 2020 03:00
Purpose: The objective of this study is to provide a systematic review of the clinical outcomes of corneal neurotization and present the pathophysiology of corneal wound healing, neurotrophic keratopathy, and corneal neurotization. Methods: A literature review of published articles and meeting abstracts between December 2008 and February 2019 in the English language with the terms “corneal neurotization,” “corneal neurotisation,” “corneal reinnervation,” and “neurotrophic keratopathy” was...
Tue Sep 01, 2020 03:00
Purpose: To use hard palate mucoperiosteum to reconstruct the upper eyelid wisely and to evaluate its function and outcome. Methods: In this case series, medial or lateral defects of the upper eyelid were reconstructed with a hard palate mucoperiosteum graft and a bandage contact lens to protect the cornea. Slit-lamp examinations, in vivo confocal microscopy, patient surveys, and pathologic examinations were performed as evaluations. Results: Seven patients were included in this study....
Tue Sep 01, 2020 03:00
No abstract available
Tue Sep 01, 2020 03:00
Purpose: The sagging eye syndrome (SES) describes a condition that presents with age-related distance esotropia, alone or in combination with cyclovertical strabismus. It has a high prevalence in those aged over age 40 years presenting with binocular diplopia. The authors aim to characterize the adnexal phenotype of those who have been diagnosed with SES. Methods: In this case–control study, patients were recruited from a prospectively maintained clinical and imaging database. The inclusion...
Tue Sep 01, 2020 03:00
Purpose: To describe the management of dermoid cysts in a pediatric referral hospital. Methods: Retrospective review of 115 patients with pathological diagnosis of dermoid cyst in a pediatric referral hospital between 2003 and 2019. Results: One hundred fifteen patients, 51 (44.3%) males, and 64 (55.7%) females were retrospectively reviewed. There were fifty-one (44.3%) right eyes and 64 (55.7%) left eyes. Mean age at surgery was 39.15 months (5.6 months–16.4 years). One hundred four...
Tue Sep 01, 2020 03:00
A 22-year-old male presented with spontaneous unilateral hemolacria and was found to have complete opacification of the ipsilateral nasolacrimal sac and duct. Endoscopic biopsy with histopathologic analysis revealed the diagnosis of nasolacrimal lymphangioma. Additional management included nasolacrimal stenting, and there was no hemolacria recurrence or epiphora. This is the first report of a nasolacrimal lymphangioma and describes the vascular malformation as a potential cause of bloody tearing.
Tue Sep 01, 2020 03:00
Purpose: The aim of this study was to investigate how the blood perfusion in human upper eyelid skin flaps is affected by the length of the flap and the degree of stretching and rotation of the flap. Methods: Twenty-nine upper eyelids were dissected as part of a blepharoplastic procedure in patients. The 1-cm wide proximal end of the flap remains attached, to mimic a random pattern skin flap (hereafter called a “skin flap”). Blood perfusion was measured with laser speckle contrast imaging...
Tue Sep 01, 2020 03:00
A 47-year-old man who presented with subacute binocular diplopia and a left head turn was found to have a right sixth nerve palsy and right optic disc edema. Radiologic imaging revealed a non-lytic right greater sphenoid wing mass with a dural tail, suggestive of a sphenoid wing meningioma. The patient underwent an orbitotomy with lesion biopsy; histopathologic analysis and subsequent imaging revealed the diagnosis of metastatic clear cell renal cell carcinoma. He developed new metastases despite...
Tue Sep 01, 2020 03:00
Purpose: The aim of this study was to examine electron microscopic features of canalicular concretions obtained from patients with canaliculiths. Methods: Canalicular concretions were obtained from 10 patients diagnosed as canaliculiths and were immediately fixed for ultrastructural analysis. Surface structure and transmission electron microscopical sections were studied. Multiple longitudinal and transverse ultrathin sections were obtained at different levels and all were studied using standard...
Tue Sep 01, 2020 03:00
No abstract available
Tue Sep 01, 2020 03:00
Purpose: To determine the association of Fitzpatrick skin type (FST) with conjunctival melanoma. Methods: Retrospective case series of 540 patients with conjunctival melanoma to assess clinical features and outcomes per FST. Results: The FST was Type I (n = 126, 23%), II (n = 337, 62%), III (n = 56, 10%), IV (n = 8, 2%), V (n = 12, 2%), and VI (n = 1,
Tue Sep 01, 2020 03:00
No abstract available
Tue Sep 01, 2020 03:00
Purpose: To review the clinical presentation, treatment, and prognosis of patients with malignant mixed tumor (carcinoma ex pleomorphic adenoma) of the lacrimal gland. Methods: Clinical records and radiographic images were reviewed for patients with malignant mixed tumor of the lacrimal gland treated at the center during 2008–2019. Results: The study included 9 patients (6 men, 3 women) aged 17–66 years (median age, 56 years). Six had primary malignant mixed tumor with no history of...
Tue Sep 01, 2020 03:00
No abstract available
Tue Sep 01, 2020 03:00
Introduction: Correction of lower eyelid retraction commonly involves one or more techniques, including recession of the eyelid retractors, spacer grafts, horizontal lid tightening, and midface lifting. However, patients presenting with cicatricial lower lid retraction following prior eyelid surgery often have scarring and concomitant ectropion or entropion that cause unpredictable wound healing, recicatrization, and suboptimal outcomes. The modified Hughes tarsoconjunctival flap is typically...
Tue Sep 01, 2020 03:00
No abstract available
Tue Sep 01, 2020 03:00
Purpose: To demonstrate the technique and report the results of endoscopic-assisted lateral orbitotomy for 6 patients with huge intraorbital dermoid cyst causing orbital roof bone erosion and dural invasion. Methods: Patients had unilateral cystic tumor with proptosis and hypoglobus for more than 6 months. There was no compressive optic neuropathy. Lateral orbitotomy procedure was performed from 2004 to 2016 by 1 surgeon. Cysts were dissected, and fluid content was aspirated to reduce the...
Tue Sep 01, 2020 03:00
Purpose: To study the in vivo morphology of nasolacrimal duct (NLD) openings into the inferior meatus. Methods: Patients undergoing endoscopic dacryocystorhinostomy and lacrimal intubation had endoscopic real-time examination of the NLD opening. Morphology of NLD openings (size, shape, mucosal folds), and their location from the axilla of the inferior turbinate were assessed. Results: Forty-three lacrimal systems of 39 adult patients (11 males, 28 females) with a mean age of 61 years...
Tue Sep 01, 2020 03:00
Orbital dermoid cysts are fairly common and arise by sequestration of surface ectoderm along skeletal suture lines during embryologic development. Although anterior dermoid cysts are generally evident in infancy, deeper cysts typically present with inflammatory symptoms in adulthood. The authors report the clinical and imaging features for 6 cases of deep orbital dermoid cysts that were identified by the presence of subconjunctival lipid droplets; to the authors’ knowledge, this case report represents...
Tue Sep 01, 2020 03:00
No abstract available
Tue Sep 01, 2020 03:00
Ocular adnexal aterio-venous malformations (AVMs) are rare congenital disabling anomalies, which may enlarge causing disfiguring deformity and rarely severe hemorrhage. These lesions are generally treated by preliminary endovascular embolization to shrink the arterio-venous malformation, followed by surgical gross total resection. The authors report a case of eyelid arterio-venous malformation in a 12-year-old girl, which progressively increased in size in few months. The patient complained mild...
Tue Sep 01, 2020 03:00
No abstract available
Tue Sep 01, 2020 03:00
Escherichia coli canaliculitis is an exceptionally rare organism to cause primary canaliculitis. The present case describes unilateral canaliculitis refractory to conventional therapy with a significant history of recurrent culture proven E. coli urinary tract infection. Microbiological analysis revealed E. coli bacilli and histological examination showed goblet cell metaplasia, subepithelial edema with acute and chronic inflammatory infiltrate. The possibility of an endogenous infection or autoinoculation...
Tue Sep 01, 2020 03:00
No abstract available
Tue Sep 01, 2020 03:00
Infantile myofibroma is a rare benign tumor usually diagnosed before the age of 2 and found in the head and neck but much more rarely in the orbital region. There have only been 7 cases of periorbital myofibromas reported in children in the literature to date. The current case is of an 8-year-old boy with a left upper eyelid myofibroma confirmed on histopathological and immunochemical analysis. A literature review of periorbital myofibromas has been performed to bring the reader up-to-date with the...
Tue Sep 01, 2020 03:00
No abstract available
Tue Sep 01, 2020 03:00
A 49-year-old otherwise healthy male presented with an odontogenic abscess and mild left facial swelling. CT imaging revealed gaseous hypodensities within the inferior orbital fissure and pterygopalatine fossa in addition to infection of the left masseter and temporalis muscle. Despite dental drainage, this rapidly progressed to orbital cellulitis with temporalis muscles abscess leading to compartment syndrome and globe tenting. He had an excellent outcome after canthotomy and cantholysis, urgent...
Tue Sep 01, 2020 03:00
No abstract available
Tue Sep 01, 2020 03:00
No abstract available
Tue Sep 01, 2020 03:00
No abstract available
Tue Sep 01, 2020 03:00
No abstract available
Tue Sep 01, 2020 03:00
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): He-Tao Bian, Gao-Hua Wang, Jun-Jie Huang, Liang Liang, Ling Xiao, Hui-Ling Wang
Fri Sep 11, 2020 13:46
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Xiaochun Lin, Kunpeng Lin, Chunxuan Lin, Jiakang Wang, Yunqiang Tang
Fri Sep 11, 2020 13:46
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Wei Han, Guo-Liang Shen
Fri Sep 11, 2020 13:46
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Zhao-Yan Cheng, Qing-Peng Xia, Yu-Hui Hu, Chen Wang, Ling He
Fri Sep 11, 2020 13:46
On February 13, 2020, the Food and Drug Administration (FDA) announced that it had requested that the manufacturer of Belviq and Belviq XR (lorcaserin and extended-release lorcaserin) voluntarily withdraw the products from the U.S. market. The agency’s request was based on its assessment of…
Thu Sep 10, 2020 03:00
Background and Objective Pediatric endoscopic pilonidal sinus treatment (PEPSiT) has become the new standard of care for pilonidal sinus disease (PSD) in pediatric patients. This study aimed to compare our current wound treatment protocol (laser epilation (LE) and oxygen‐enriched oil‐based gel dressing) with our previous protocol (silver sulfadiazine spray) and demonstrate its efficacy as means to prevent PSD recurrence in children undergoing PEPSiT. Study Design/Materials and Methods We retrospectively...
Thu Sep 10, 2020 20:45
Background and Objectives Photon‐induced photoacoustic streaming (PIPS) and shockwave‐enhanced emission photoacoustic streaming (SWEEPS) are two promising laser‐activated irrigation (LAI) methods for root canal irrigation. Their performance in driving irrigant flush in a complex root canal system will be evaluated by microscale particle image velocimetry (μPIV) measurement and will be compared with that of ultrasonic‐activated irrigation (UAI). Study Design/Materials and Methods A μPIV system...
Thu Sep 10, 2020 20:33
Nature Communications, Published online: 11 September 2020; doi:10.1038/s41467-020-18368-xThe transcriptional regulator YAP shuttles rapidly between the cytoplasm and nucleus, but whether and how dynamics such as amplitude and frequency affect target gene transcription is unclear. Here, using live imaging of endogenous YAP and target-gene transcription, the authors show that YAP-dependent signalling is encoded through rapid and concerted changes in the nucleo-cytoplasmic distribution of YAP.
Fri Sep 11, 2020 03:00
Nature Communications, Published online: 11 September 2020; doi:10.1038/s41467-020-18363-2Interfacial fluctuations at the nanoscale, such as shape evolution of a growing crystal, are prohibitively difficult to study experimentally. Here, the authors are able to map the kinetic and thermodynamic parameters involved in shaping of nanoparticle supracrystals by directly imaging the fluctuating crystal surface by liquid-phase TEM, and analyzing it in the context of capillary wave theory.
Fri Sep 11, 2020 03:00
Nature Communications, Published online: 11 September 2020; doi:10.1038/s41467-020-18650-yPublisher Correction: Dynamics for El Niño-La Niña asymmetry constrain equatorial-Pacific warming pattern
Fri Sep 11, 2020 03:00
Nature Communications, Published online: 11 September 2020; doi:10.1038/s41467-020-18405-9Previous work showed that the caspase 1 inhibitor VX-765 rescued cognitive deficits in the J20 mouse model of Alzheimer’s disease, and this may occur via reduced inflammation. Here the authors show that administration of the drug prior to onset of cognitive deficits and pathology in mice delays the onset of deficits.
Fri Sep 11, 2020 03:00
Nature Communications, Published online: 11 September 2020; doi:10.1038/s41467-020-18443-3HMGB1 is an inflammatory mediator released by a variety of cell types. Here, the authors show that unlike IL-1β, HMGB1 is released non-specifically following cell lysis.
Fri Sep 11, 2020 03:00
Nature Communications, Published online: 11 September 2020; doi:10.1038/s41467-020-18448-yThe transition from wide continental rift to continental break-up remains enigmatic. Here, the authors show that northern margin of the South China Sea records the transition between wide continental rift to a highly extended continental margin, with strikingly similar structures and metamorphic core complexes to those described from the North American Cordillera and the Aegean.
Fri Sep 11, 2020 03:00
Nature Communications, Published online: 11 September 2020; doi:10.1038/s41467-020-18146-9Mandibuloacral dysplasias (MADs) are rare progeroid syndromes characterized by nuclear morphological and functional abnormalities. Here the authors report that loss of mitochondrial membrane protein MTX2 causes a progeroid MAD sharing clinical features with lamin-associated progeroid syndromes.
Fri Sep 11, 2020 03:00
Nature Communications, Published online: 11 September 2020; doi:10.1038/s41467-020-18351-6Place cells in the hippocampus fire action potentials at spatially selective firing fields that collectively map the environments. Here, the authors show how these activity patterns develop with experience in mice and determine the importance of competitive learning in this process.
Fri Sep 11, 2020 03:00
People who inject drugs (PWID) are a dominant risk group afflicted by blood-borne viruses, mental health disorders, and social precariousness. Risk reduction interventions are administered to PWID regardless of their characteristics or specific risks. The objective of this cross-sectional analysis was to empirically identify profiles of PWID regarding their drug use, risk behaviors, and mental health in order to tailor adapted interventions taking into account limited access to comprehensive care...
Fri Sep 11, 2020 11:05
Summary Background Crenigacestat is a potent Notch inhibitor that decreases Notch signaling and its downstream biological effects. Here, we report the results from Part F of study 16F-MC-JJCA designed to evaluate the safety, pharmacokinetics (PK), and antitumor activity of crenigacestat with prednisone in advanced or metastatic cancer. The combination was planned to mitigate gastrointestinal toxicities. Methods Eligible patients (Study Part F) received crenigacestat loading dose...
Fri Sep 11, 2020 03:00
Summary Today, pancreatic cancer (PC) is a major health problem in the United States. It remains a challenge to develop efficacious clinically useful PC therapies. New avenues, based on translational approaches and innovative validated biomarkers could be a preclinical option to evaluate PC drug candidates or drug combinations before clinical trials. Herein, we describe evaluation of combination therapies by incorporating a novel pathway modulator, p53-Activator Wnt Inhibitor-2...
Fri Sep 11, 2020 03:00
Publication date: Available online 10 September 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Shinkuro Yamamoto, Hideo Fukuhara, Takashi Karashima, Keiji Inoue
Fri Sep 11, 2020 13:22
Key points Knee‐extensors demonstrate greater fatigue‐resistance in females compared to males during single‐limb and whole‐body exercise. For single‐limb exercise, the intensity‐duration relationship is different between sexes, with females sustaining a greater relative intensity of exercise. This study established the power‐duration relationship during cycling, then assessed fatigability during critical power‐matched exercise within the heavy and severe intensity domains. When critical power...
Thu Sep 10, 2020 21:24
The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at the Journal. In this audio interview conducted…
Thu Sep 10, 2020 03:00
Objectives: Few, evidence-based programs have been developed to prepare social skills for students with autism spectrum disorder (ASD) transitioning to the workplace or college setting. This article describes a pilot curriculum developed for Tarrant County College (TCC) to address the transitional needs of high school students with ASD to a vocation or college. Methods: TCC enrolled 123 high school students across the ASD who were taught a 2-h, 2-semesters course on how to apply for college as well...
Fri Sep 11, 2020 12:26
Abstract Psoriasis is associated with psychological comorbidities. We evaluated the effectiveness of additional psychopharmacotherapy on the clinical severity and associated anxiety and depression in psoriasis. 173 patients were enrolled with psoriasis and associated anxiety and depression. Spielberger State‐Trait Anxiety Inventory (STAI) and The Beck Depression Scale (BDI) were used to assess anxiety and depression parameters. The IA main group included patients with anxiety disorders who received...
Thu Sep 10, 2020 12:18
Objective Traditionally, after total laryngopharyngectomy (TLP), patients cannot speak without a prosthesis or an artificial larynx. In Taiwan, most patients use a commercialized pneumatic laryngeal device (PLD). Phonatory tube reconstruction with the anterolateral thigh (ALT) flap is a novel, modified version of synchronous digestive and phonatory reconstruction involving a free muscular cutaneous flap. This study reviewed and compared speech performance between patients who underwent novel flap...
Thu Sep 10, 2020 22:50
Objectives/Hypothesis Predictors of free tissue transfer (FTT) failure and the need for postoperative revision (POR) have been extensively studied; however, there are little data evaluating outcomes when intraoperative revision (IOR) at initial surgery is required. This study seeks to better understand the impact IOR of the pedicle has on FTT outcomes. Study Design Retrospective review of 2482 consecutive patients across three tertiary institutions. Methods Adult patients (>18) who...
Thu Sep 10, 2020 22:44
Male and female otolaryngologists all attend the same accredited medical schools, complete the same accredited residency programs, and take the same board certification exams; however, female otolaryngologist are paid 77 cents on the dollar compared to their male colleagues. Even after accounting for age, experience, faculty rank, research productivity, and clinical revenue, significant gender pay gaps exist across all professor levels. The goal of this review is to improve our understanding of how...
Thu Sep 10, 2020 22:38
Objectives/Hypothesis Nodal involvement is frequent in patients with differentiated thyroid cancers (DTCs), but its prognostic relevance is not univocal. Some characteristics of nodal metastases can increase the risk of recurrence. We attempted to quantify the impact on survival of nodal factors included in the American Thyroid Association (ATA) risk stratification system in N1b patients with DTC. Study Design Retrospective study. Methods A retrospective analysis of patients affected...
Thu Sep 10, 2020 22:28
Objectives/Hypothesis Although the Hadad‐Bassagusteguy flap represents the first choice for middle and posterior skull base reconstruction and coverage of exposed bony areas, in some cases it is unavailable. The aim of this study is to describe, as an alternative option in selected cases, a modified posterior pedicle middle turbinate flap (mPPMTF) extended to the lacrimal area. Anatomical features, step‐by‐step harvesting technique, and surgical applications are presented. Study design Anatomic...
Thu Sep 10, 2020 22:24
Abstract Tween (polysorbate) 20 and 80 are surfactants used for the development of parenteral protein drugs, due to their beneficial safety profile and stabilisation properties. To elucidate the mechanism by which Tween 20 and 80 stabilise proteins in aqueous solutions, either by a “direct” protein to surfactant interaction and/or by an interaction with the protein film at the air–water interface, we used spectroscopic (Infrared Reflection Absorption Spectroscopy, IRRAS) and microscopic...
Fri Sep 11, 2020 03:00
Abstract Purpose Evidence about bone microarchitecture in Asian type 1 diabetes (T1D) patients is lacking. We assessed the bone microarchitecture in T1D patients versus controls and compare the differences between juvenile-onset and adult-onset T1D patients. Methods This cross-sectional study recruited 32 Asian males with T1D and 32 age-, sex-, and...
Fri Sep 11, 2020 03:00
Abstract Purpose To evaluate the risk of mass enlargement and endocrine function modification in patients with adrenal incidentaloma (AI). Methods In this retrospective study, we examined clinical and hormonal characteristics of 310 patients with AI (200 females and 110 males; age: 58.3 ± 12.9 years), followed up for a median (interquartile range)...
Fri Sep 11, 2020 03:00
Abstract Introduction In cross-country skiing, the repetitive ventilation of large amounts of cold and dry air strains the airways. The aim of this systematic review was to establish an overview of the current literature on asthma in cross-country skiers, biathletes and ski-orienteers. Methods Six databases were searched on August 29, 2019. The search...
Fri Sep 11, 2020 03:00
Abstract An increased ability to supply energy to skeletal muscle is expected to contribute to greater athletic performance, and therefore, a variety of training methods are used for improving these energy supply systems. These methods are classified into two broad categories: a bout of continuous exercise at a given load/intensity and intermittent bouts of exercise at a given load/intensity with recovery intervals. Interestingly, recent work suggests that a training method which...
Fri Sep 11, 2020 03:00
Publication date: Available online 10 September 2020Source: American Journal of OtolaryngologyAuthor(s): Paolo J. Fantozzi, Emanuele Pampena, Domenico Di Vanna, Eugenia Pellegrino, Daniele Corbi, Stefano Mammucari, Federica Alessi, Riccardo Pampena, Giuliano Bertazzoni, Salvatore Minisola, Claudio Maria Mastroianni, Antonella Polimeni, Umberto Romeo, Alessandro Villa
Fri Sep 11, 2020 12:45
O_LIThe rise of globalization has spread organisms beyond their natural range, allowing further opportunity for introduced species to adapt to novel environments and potentially become aggressive invaders. Yet, the role of niche evolution in promoting the success of invasive species remains poorly understood. Here, we use thermal performance curves (TPCs) to test the following hypotheses about thermal adaptation during the invasion process. First, in response to strong selection from novel temperature...
Sun Sep 13, 2020 03:00
The rate at which plants grow is a major functional trait in plant ecology. However, little is known about its evolution in natural populations. Here, we investigate evolutionary and environmental factors shaping variation in the growth rate of Arabidopsis thaliana. We used plant diameter as a proxy to monitor plant growth over time in environments that mimicked latitudinal differences in the intensity of natural light radiation, across a set of 278 genotypes sampled within four broad regions, including...
Fri Sep 11, 2020 03:00
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