A modelling effort was made to try to predict the life of downhole tubes or casings, synthetically considering the effect of service influencing factors on corrosion rate. Based on the discussed corrosion mechanism and corrosion processes of downhole tubes, a mathematic model was established. For downhole tubes, the influencing factors are environmental parameters and stress, which vary with service duration. Stress and the environmental parameters including water content, partial pressure of H2S and CO2, pH value, total pressure and temperature, were considered to be time-dependent. Based on the model, life-span of an L80 downhole tube in oilfield Halfaya, an oilfield in Iraq, was predicted. The results show that life-span of the L80 downhole tube in Halfaya is 247 months (approximately 20 years) under initial stress of 0.1 yield strength and 641 months (approximately 53 years) under no initial stress, which indicates that an initial stress of 0.1 yield strength will reduce the life-span by more than half.
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Παρασκευή 2 Σεπτεμβρίου 2016
Materials, Vol. 9, Pages 741: A Modelling Study for Predicting Life of Downhole Tubes Considering Service Environmental Parameters and Stress
Materials, Vol. 9, Pages 752: Expression of Concern: Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine. Materials 2009, 2, 1975–2045
We wish to make readers aware that the text in the published paper [1] contains substantial overlap with a previous paper by the same author [2].[...]
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Nutrients, Vol. 8, Pages 539: Role of Young Child Formulae and Supplements to Ensure Nutritional Adequacy in U.K. Young Children
The European Food Safety Authority (EFSA) states that young child formulae (YCFs) "cannot be considered as a necessity to satisfy the nutritional requirements" of children aged 12–36 months. This study quantifies the dietary changes needed to ensure nutritional adequacy in U.K. young children who consume YCFs and/or supplements and in those who do not. Dietary data from 1147 young children (aged 12–18 months) were used to identify, using linear programming models, the minimum changes needed to ensure nutritional adequacy: (i) by changing the quantities of foods initially consumed by each child (repertoire-foods); and (ii) by introducing new foods (non-repertoire-foods). Most of the children consumed neither YCFs, nor supplements (61.6%). Nutritional adequacy with repertoire-foods alone was ensured for only one child in this group, against 74.4% of the children consuming YCFs and supplement. When access to all foods was allowed, smaller food changes were required when YCFs and supplements were initially consumed than when they were not. In the total sample, the main dietary shifts needed to ensure nutritional adequacy were an increase in YCF and a decrease in cow's milk (+226 g/day and −181 g/day, respectively). Increasing YCF and supplement consumption was the shortest way to cover the EFSA nutrient requirements of U.K. children.
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Nutrients, Vol. 8, Pages 540: Hepcidin is a Better Predictor of Iron Stores in Premenopausal Women than Blood Loss or Dietary Intake
The relationship between dietary intake, circulating hepcidin and iron status in free-living premenopausal women has not been explored. This cross-sectional study aimed to identify dietary determinants of iron stores after accounting for blood loss and to determine whether iron intake predicts iron stores independently of hepcidin in a sample of Australian women. Three hundred thirty eight women aged 18–50 years were recruited. Total intake and food sources of iron were determined via food frequency questionnaire; the magnitude of menstrual losses was estimated by self-report; and blood donation volume was quantified using blood donation records and self-reported donation frequency. Serum samples were analysed for ferritin, hepcidin and C-reactive protein concentrations. Linear regression was used to investigate associations. Accounting for blood loss, each 1 mg/day increase in dietary iron was associated with a 3% increase in iron stores (p = 0.027); this association was not independent of hepcidin. Hepcidin was a more influential determinant of iron stores than blood loss and dietary factors combined (R2 of model including hepcidin = 0.65; R2 of model excluding hepcidin = 0.17, p for difference <0.001), and increased hepcidin diminished the positive association between iron intake and iron stores. Despite not being the biggest contributor to dietary iron intake, unprocessed meat was positively associated with iron stores, and each 10% increase in consumption was associated with a 1% increase in iron stores (p = 0.006). No other dietary factors were associated with iron stores. Interventions that reduce hepcidin production combined with dietary strategies to increase iron intake may be important means of improving iron status in women with depleted iron stores.
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Sensors, Vol. 16, Pages 1414: Dynamic Aberration Correction for Conformal Window of High-Speed Aircraft Using Optimized Model-Based Wavefront Sensorless Adaptive Optics
For high-speed aircraft, a conformal window is used to optimize the aerodynamic performance. However, the local shape of the conformal window leads to large amounts of dynamic aberrations varying with look angle. In this paper, deformable mirror (DM) and model-based wavefront sensorless adaptive optics (WSLAO) are used for dynamic aberration correction of an infrared remote sensor equipped with a conformal window and scanning mirror. In model-based WSLAO, aberration is captured using Lukosz mode, and we use the low spatial frequency content of the image spectral density as the metric function. Simulations show that aberrations induced by the conformal window are dominated by some low-order Lukosz modes. To optimize the dynamic correction, we can only correct dominant Lukosz modes and the image size can be minimized to reduce the time required to compute the metric function. In our experiment, a 37-channel DM is used to mimic the dynamic aberration of conformal window with scanning rate of 10 degrees per second. A 52-channel DM is used for correction. For a 128 × 128 image, the mean value of image sharpness during dynamic correction is 1.436 × 10−5 in optimized correction and is 1.427 × 10−5 in un-optimized correction. We also demonstrated that model-based WSLAO can achieve convergence two times faster than traditional stochastic parallel gradient descent (SPGD) method.
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Polymers, Vol. 8, Pages 326: Process, Design and Materials for Unidirectionally Tilted Polymeric Micro/Nanohairs and Their Adhesion Characteristics
Recent research in the field of gecko-inspired dry adhesive has focused on modifying the material and structural properties of polymer-based nanohairs. Polymers such as polystyrene (PS), high-density polyethylene (HDPE), ultraviolet curable epoxy (SU-8), polyurethane acrylate (PUA), polycarbonate (PC), and polydimethyl siloxane (PDMS) can fulfill many mechanical property requirements, are easily tunable, and can be produced via large-scale fabrication. However, the fabrication process for tilted structure remains challenging. The tilted structure is a crucial factor in high-degree conformal contact, which facilitates high adhesion, low effective modulus, and directional adhesion properties. Recent studies have attempted to create a tilted structure by applying beam irradiation, mechanical and thermal stress, and magnetic fields. This review provides a comprehensive investigation into advanced strategies for producing tilted polymeric nanostructures and their potential applications in the near future.
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Algorithms, Vol. 9, Pages 60: HMM Adaptation for Improving a Human Activity Recognition System
When developing a fully automatic system for evaluating motor activities performed by a person, it is necessary to segment and recognize the different activities in order to focus the analysis. This process must be carried out by a Human Activity Recognition (HAR) system. This paper proposes a user adaptation technique for improving a HAR system based on Hidden Markov Models (HMMs). This system segments and recognizes six different physical activities (walking, walking upstairs, walking downstairs, sitting, standing and lying down) using inertial signals from a smartphone. The system is composed of a feature extractor for obtaining the most relevant characteristics from the inertial signals, a module for training the six HMMs (one per activity), and the last module for segmenting new activity sequences using these models. The user adaptation technique consists of a Maximum A Posteriori (MAP) approach that adapts the activity HMMs to the user, using some activity examples from this specific user. The main results on a public dataset have reported a significant relative error rate reduction of more than 30%. In conclusion, adapting a HAR system to the user who is performing the physical activities provides significant improvement in the system's performance.
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Sensors, Vol. 16, Pages 1421: Performance Optimization of Priority Assisted CSMA/CA Mechanism of 802.15.6 under Saturation Regime
Due to the recent development in the field of Wireless Sensor Networks (WSNs), the Wireless Body Area Networks (WBANs) have become a major area of interest for the developers and researchers. Human body exhibits postural mobility due to which distance variation occurs and the status of connections amongst sensors change time to time. One of the major requirements of WBAN is to prolong the network lifetime without compromising on other performance measures, i.e., delay, throughput and bandwidth efficiency. Node prioritization is one of the possible solutions to obtain optimum performance in WBAN. IEEE 802.15.6 CSMA/CA standard splits the nodes with different user priorities based on Contention Window (CW) size. Smaller CW size is assigned to higher priority nodes. This standard helps to reduce delay, however, it is not energy efficient. In this paper, we propose a hybrid node prioritization scheme based on IEEE 802.15.6 CSMA/CA to reduce energy consumption and maximize network lifetime. In this scheme, optimum performance is achieved by node prioritization based on CW size as well as power in respective user priority. Our proposed scheme reduces the average back off time for channel access due to CW based prioritization. Additionally, power based prioritization for a respective user priority helps to minimize required number of retransmissions. Furthermore, we also compare our scheme with IEEE 802.15.6 CSMA/CA standard (CW assisted node prioritization) and power assisted node prioritization under postural mobility in WBAN. Mathematical expressions are derived to determine the accurate analytical model for throughput, delay, bandwidth efficiency, energy consumption and life time for each node prioritization scheme. With the intention of analytical model validation, we have performed the simulations in OMNET++/MIXIM framework. Analytical and simulation results show that our proposed hybrid node prioritization scheme outperforms other node prioritization schemes in terms of average network delay, average throughput, average bandwidth efficiency and network lifetime.
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Marine Drugs, Vol. 14, Pages 160: A Coral-Derived Compound Improves Functional Recovery after Spinal Cord Injury through Its Antiapoptotic and Anti-Inflammatory Effects
Background: Our previous in vitro results demonstrated that 11-dehydrosinulariolide significantly reduced 6-hydroxydopamine-induced cytotoxicity and apoptosis in a human neuroblastoma cell line, SH-SY5Y, and suppressed the expression of inducible NO synthase (iNOS) and cyclooxygenase 2 in lipopolysaccharide-stimulated macrophage cells. The neuroprotective and anti-inflammatory effects of 11-dehydrosinulariolide may be suitable for treating spinal cord injury (SCI). Methods: In the present study, Wistar rats were pretreated with 11-dehydrosinulariolide or saline through intrathecal injection after a thoracic spinal cord contusion injury induced using a New York University (NYU) impactor. The apoptotic cells were assessed using the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. The expression and localization of proinflammatory, apoptosis-associated and cell survival-related pathway proteins were examined through immunoblotting and immunohistochemistry. Results: 11-Dehydrosinulariolide attenuated SCI-induced cell apoptosis by upregulating the antiapoptotic protein Bcl-2 and cell survival-related pathway proteins p-Akt and p-ERK, 8 h after SCI. Furthermore, the transcription factor p-CREB, which regulates Bcl-2 expression, was upregulated after 11-dehydrosinulariolide treatment. On day 7 after SCI, 11-dehydrosinulariolide exhibited an anti-inflammatory effect, attenuating SCI-induced upregulation of the inflammatory proteins iNOS and tumor necrosis factor-α. 11-Dehydrosinulariolide also induced an increase in the expression of arginase-1 and CD206, markers of M2 microglia, in the injured spinal cord on day 7 after SCI. Thus, the anti-inflammatory effect of 11-dehydrosinulariolide may be related to the promotion of an alternative pathway of microglia activation. Conclusion: The results show that 11-dehydrosinulariolide exerts antiapoptotic effects at 8 h after SCI and anti-inflammatory effects at 7 days after SCI. We consider that this compound may be a promising therapeutic agent for SCI.
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Sustainability, Vol. 8, Pages 884: Eco-Labeled Seafood: Determinants for (Blue) Green Consumption
Eco-certification has become an increasingly popular market-based tool in the endeavor to reduce negative environmental impacts from fisheries and aquaculture. In this study, we aimed at investigating which psychological consumer characteristics influence demand for eco-labeled seafood by correlating consumers' stated purchasing of eco-labeled seafood to nine variables: environmental knowledge regarding seafood production, familiarity with eco-labels, subjective knowledge, pro-environmental self-identification, sense of personal responsibility, concern for negative environmental impacts from seafood production, perceived consumer effectiveness, gender and education. Questionnaires were distributed to consumers in Stockholm, Sweden, and the data were tested with multiple regression analysis using linear modeling and model averaging (n = 371). Two variables were the best predictors of stated purchasing of eco-labeled seafood: (i) recognition and understanding of eco-labels for seafood (Marine Stewardship Council, Fish for Life, Aquaculture Stewardship Council and KRAV); and (ii) concern for negative environmental impacts associated with seafood production. Meanwhile, consumer environmental knowledge was a weaker predictor. Results from this study suggest that strengthening the emotional component of consumer decision-making and improving the level of consumer familiarity with seafood eco-labels could stimulate more pro-environmental seafood consumption.
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Sensors, Vol. 16, Pages 1419: Characterization of the ER-Targeted Low Affinity Ca2+ Probe D4ER
Calcium ion (Ca2+) is a ubiquitous intracellular messenger and changes in its concentration impact on nearly every aspect of cell life. Endoplasmic reticulum (ER) represents the major intracellular Ca2+ store and the free Ca2+ concentration ([Ca2+]) within its lumen ([Ca2+]ER) can reach levels higher than 1 mM. Several genetically-encoded ER-targeted Ca2+ sensors have been developed over the last years. However, most of them are non-ratiometric and, thus, their signal is difficult to calibrate in live cells and is affected by shifts in the focal plane and artifactual movements of the sample. On the other hand, existing ratiometric Ca2+ probes are plagued by different drawbacks, such as a double dissociation constant (Kd) for Ca2+, low dynamic range, and an affinity for the cation that is too high for the levels of [Ca2+] in the ER lumen. Here, we report the characterization of a recently generated ER-targeted, Förster resonance energy transfer (FRET)-based, Cameleon probe, named D4ER, characterized by suitable Ca2+ affinity and dynamic range for monitoring [Ca2+] variations within the ER. As an example, resting [Ca2+]ER have been evaluated in a known paradigm of altered ER Ca2+ homeostasis, i.e., in cells expressing a mutated form of the familial Alzheimer's Disease-linked protein Presenilin 2 (PS2). The lower Ca2+ affinity of the D4ER probe, compared to that of the previously generated D1ER, allowed the detection of a conspicuous, more clear-cut, reduction in ER Ca2+ content in cells expressing mutated PS2, compared to controls.
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JMSE, Vol. 4, Pages 53: Wave Energy Converter Annual Energy Production Uncertainty Using Simulations
Critical to evaluating the economic viability of a wave energy project is: (1) a robust estimate of the electricity production throughout the project lifetime and (2) an understanding of the uncertainty associated with said estimate. Standardization efforts have established mean annual energy production (MAEP) as the metric for quantification of wave energy converter (WEC) electricity production and the performance matrix approach as the appropriate method for calculation. General acceptance of a method for calculating the MAEP uncertainty has not yet been achieved. Several authors have proposed methods based on the standard engineering approach to error propagation, however, a lack of available WEC deployment data has restricted testing of these methods. In this work the magnitude and sensitivity of MAEP uncertainty is investigated. The analysis is driven by data from simulated deployments of 2 WECs of different operating principle at 4 different locations. A Monte Carlo simulation approach is proposed for calculating the variability of MAEP estimates and is used to explore the sensitivity of the calculation. The uncertainty of MAEP ranged from 2%–20% of the mean value. Of the contributing uncertainties studied, the variability in the wave climate was found responsible for most of the uncertainty in MAEP. Uncertainty in MAEP differs considerably between WEC types and between deployment locations and is sensitive to the length of the input data-sets. This implies that if a certain maximum level of uncertainty in MAEP is targeted, the minimum required lengths of the input data-sets will be different for every WEC-location combination.
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Sustainability, Vol. 8, Pages 887: Effects of Fertilization on Ramie (Boehmeria nivea L.) Growth, Yield and Fiber Quality
Ramie (Boehmeria nivea L.) is one of the most important sources of natural fiber. The yield and fiber quality of ramie are affected by mineral nutrients, particularly nitrogen (N), phosphorus (P), and potassium (K). In the present study, we aimed to quantify the influence of N, P, and K fertilizers on growth, yield, and fiber quality of ramie. To this end, ramie plants grown under different fertilizer treatments (no fertilizer, N, P, K, NP, NK, PK, and NPK) were evaluated for differences in plant height, stem diameter, stem fresh and dry weights, number of stems, fiber fresh and dry weights, fiber quality (breaking strength, elongation, and diameter), and total N and P content. Across all fertilizer treatments, NPK, followed by NK, had the greatest significant effect for increasing plant growth, yield, and fiber quality as compared with control plants, whereas P application had the least effect. Plants fertilized with NPK showed strong positive correlations among fiber yield and quality traits with morphological parameters such as plant height, biomass, stem diameter, and numbers of stem. The p correlation of fiber breaking strength with stem diameter (r2 = 0.79), stem biomass (r2 = 0.88), N contents (r2 = 0.91) and P contents (r2 = 0.83) indicated that the combined application of NPK (150, 75,150 kg·ha−1) significantly enhances yield and fiber quality in ramie. Thus, it is suggested that optimum fertilization is important for sustainable ramie production.
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Polymers, Vol. 8, Pages 305: Synthesis of Polyaniline-Coated Graphene Oxide@SrTiO3 Nanocube Nanocomposites for Enhanced Removal of Carcinogenic Dyes from Aqueous Solution
The present investigation highlights the synthesis of polyaniline (PANI)-coated graphene oxide doped with SrTiO3 nanocube nanocomposites through facile in situ oxidative polymerization method for the efficient removal of carcinogenic dyes, namely, the cationic dye methylene blue (MB) and the anionic dye methyl orange (MO). The presence of oxygenated functional groups comprised of hydroxyl and epoxy groups in graphene oxide (GO) and nitrogen-containing functionalities such as imine groups and amine groups in polyaniline work synergistically to impart cationic and anionic nature to the synthesised nanocomposite, whereas SrTiO3 nanocubes act as spacers aiding in segregation of GO sheets, thereby increasing the effective surface area of nanocomposite. The synthesised nanocomposites were characterised by field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The adsorption efficiencies of graphene oxide (GO), PANI homopolymer, and SrTiO3 nanocubes-doped nanocomposites were assessed by monitoring the adsorption of methylene blue and methyl orange dyes from aqueous solution. The adsorption efficiency of nanocomposites doped with SrTiO3 nanocubes were found to be of higher magnitude as compared with undoped nanocomposite. Moreover, the nanocomposite with 2 wt % SrTiO3 with respect to graphene oxide demonstrated excellent adsorption behaviour with 99% and 91% removal of MB and MO, respectively, in a very short duration of time.
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Sensors, Vol. 16, Pages 1416: The Front-End Readout as an Encoder IC for Magneto-Resistive Linear Scale Sensors
This study proposes a front-end readout circuit as an encoder chip for magneto-resistance (MR) linear scales. A typical MR sensor consists of two major parts: one is its base structure, also called the magnetic scale, which is embedded with multiple grid MR electrodes, while another is an "MR reader" stage with magnets inside and moving on the rails of the base. As the stage is in motion, the magnetic interaction between the moving stage and the base causes the variation of the magneto-resistances of the grid electrodes. In this study, a front-end readout IC chip is successfully designed and realized to acquire temporally-varying resistances in electrical signals as the stage is in motions. The acquired signals are in fact sinusoids and co-sinusoids, which are further deciphered by the front-end readout circuit via newly-designed programmable gain amplifiers (PGAs) and analog-to-digital converters (ADCs). The PGA is particularly designed to amplify the signals up to full dynamic ranges and up to 1 MHz. A 12-bit successive approximation register (SAR) ADC for analog-to-digital conversion is designed with linearity performance of ±1 in the least significant bit (LSB) over the input range of 0.5–2.5 V from peak to peak. The chip was fabricated by the Taiwan Semiconductor Manufacturing Company (TSMC) 0.35-micron complementary metal oxide semiconductor (CMOS) technology for verification with a chip size of 6.61 mm2, while the power consumption is 56 mW from a 5-V power supply. The measured integral non-linearity (INL) is −0.79–0.95 LSB while the differential non-linearity (DNL) is −0.68–0.72 LSB. The effective number of bits (ENOB) of the designed ADC is validated as 10.86 for converting the input analog signal to digital counterparts. Experimental validation was conducted. A digital decoder is orchestrated to decipher the harmonic outputs from the ADC via interpolation to the position of the moving stage. It was found that the displacement measurement error is within ±15 µm for a measuring range of 10 mm.
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Fibers, Vol. 4, Pages 25: Nanofibers: Friend or Foe?
Since the early 1990s nanofibers, particularly those of a carbonaceous content [1] have received heightened interest due to their advantageous physico-chemical characteristics (e.g., high strength, stiffness, semi-conductor, increased thermal conductivity and one of the highest Young's modulus [2]).[...]
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Symmetry, Vol. 8, Pages 90: The Combination of a Fuzzy Analytical Hierarchy Process and the Taguchi Method to Evaluate the Malaysian Users’ Willingness to Pay for Public Transportation
This study is an attempt to overcome the lack of reliable estimates on the willingness of Malaysian users to pay for public transportation (particularly buses) through a combined analysis of a fuzzy analytical hierarchy process (F-AHP) and the Taguchi method. This is a ground-breaking study in the attempt to evaluate the bus users' satisfaction factors based on the F-AHP, and find the pattern for the users' willingness to pay (WTP) characteristic by reducing the travel time with the Taguchi application. The data were collected from the public transportation users' intentions in Kelang Valley, Kuala Lumpur, Malaysia. The results convinced us that, for complex data, one requires flexible approaches that can adjust their combination methods to the properties of analyzed datasets. This study is interested in initiating the use of a system combination strategy to have a better understanding of the factors that motivate the public transportation users to be willing to pay for the public transportation's fare.
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Sensors, Vol. 16, Pages 1408: PSO-SVM-Based Online Locomotion Mode Identification for Rehabilitation Robotic Exoskeletons
Locomotion mode identification is essential for the control of a robotic rehabilitation exoskeletons. This paper proposes an online support vector machine (SVM) optimized by particle swarm optimization (PSO) to identify different locomotion modes to realize a smooth and automatic locomotion transition. A PSO algorithm is used to obtain the optimal parameters of SVM for a better overall performance. Signals measured by the foot pressure sensors integrated in the insoles of wearable shoes and the MEMS-based attitude and heading reference systems (AHRS) attached on the shoes and shanks of leg segments are fused together as the input information of SVM. Based on the chosen window whose size is 200 ms (with sampling frequency of 40 Hz), a three-layer wavelet packet analysis (WPA) is used for feature extraction, after which, the kernel principal component analysis (kPCA) is utilized to reduce the dimension of the feature set to reduce computation cost of the SVM. Since the signals are from two types of different sensors, the normalization is conducted to scale the input into the interval of [0, 1]. Five-fold cross validation is adapted to train the classifier, which prevents the classifier over-fitting. Based on the SVM model obtained offline in MATLAB, an online SVM algorithm is constructed for locomotion mode identification. Experiments are performed for different locomotion modes and experimental results show the effectiveness of the proposed algorithm with an accuracy of 96.00% ± 2.45%. To improve its accuracy, majority vote algorithm (MVA) is used for post-processing, with which the identification accuracy is better than 98.35% ± 1.65%. The proposed algorithm can be extended and employed in the field of robotic rehabilitation and assistance.
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Geosciences, Vol. 6, Pages 39: Regional Lithological Mapping Using ASTER-TIR Data: Case Study for the Tibetan Plateau and the Surrounding Area
The mineralogical indices the Quartz Index (QI), Carbonate Index (CI) and Mafic Index (MI) for ASTER multispectral thermal infrared (TIR) data were applied to various geological materials for regional lithological mapping on the Tibetan Plateau. Many lithological and structural features are not currently well understood in the central Tibetan Plateau, including the distribution of mafic-ultramafic rocks related to the suture zones, the quartzose and carbonate sedimentary rocks accreted to the Eurasian continent, and sulfate layers related to the Tethys and neo-Tethys geological setting. These rock types can now be mapped with the interpretation of the processed ASTER TIR images described in this paper. A methodology is described for the processing of ASTER TIR data applied to a very wide region of the Tibetan Plateau. The geometrical and radiometric performance of the processed images is discussed, and the advantages of using ortho-rectified data are shown. The challenges of using ASTER data with a small footprint in addition to selecting an appropriate subset of scenes are also examined. ASTER scenes possess a narrow swath width when compared to LANDSAT data (60 km vs. 185 km, respectively). Furthermore, the ASTER data archive is vast, consisting of approximately three million images. These details can present an added level of complexity during an image processing workflow. Finally, geological interpretations made on the maps of the indices are compared with prior geological field studies. The results from the investigations suggest that the indices perform well in the classification of quartzose rocks based on the carbonate and mafic mineral content, in addition to the granitic rocks based on the feldspar content.
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Remote Sensing, Vol. 8, Pages 728: Environmental Concerns of Deforestation in Myanmar 2001–2010
Deforestation in Myanmar has recently attracted much attention worldwide. This study examined spatio-temporal patterns of deforestation and forest carbon flux in Myanmar from 2001 to 2010 and environmental impacts at the regional scale using land products of the Moderate Resolution Imaging Spectroradiometer (MODIS). The results suggest that the total deforestation area in Myanmar was 21,178.8 km2, with an annual deforestation rate of 0.81%, and that the total forest carbon release was 20.06 million tons, with an annual rate of 0.37%. Mangrove forests had the highest deforestation and carbon release rates, and deciduous forests had both the largest deforestation area and largest amount of carbon release. During the study period, the south and southwestern regions of Myanmar, especially Ayeyarwady and Rakhine, were deforestation hotspots (i.e., the highest deforestation and carbon release rates occurred in these regions). Deforestation caused significant carbon release, reduced evapotranspiration (ET), and increased land surface temperatures (LSTs) in deforested areas in Myanmar during the study period. Constructive policy recommendations are put forward based on these research results.
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Algorithms, Vol. 9, Pages 59: Binary Cockroach Swarm Optimization for Combinatorial Optimization Problem
The Cockroach Swarm Optimization (CSO) algorithm is inspired by cockroach social behavior. It is a simple and efficient meta-heuristic algorithm and has been applied to solve global optimization problems successfully. The original CSO algorithm and its variants operate mainly in continuous search space and cannot solve binary-coded optimization problems directly. Many optimization problems have their decision variables in binary. Binary Cockroach Swarm Optimization (BCSO) is proposed in this paper to tackle such problems and was evaluated on the popular Traveling Salesman Problem (TSP), which is considered to be an NP-hard Combinatorial Optimization Problem (COP). A transfer function was employed to map a continuous search space CSO to binary search space. The performance of the proposed algorithm was tested firstly on benchmark functions through simulation studies and compared with the performance of existing binary particle swarm optimization and continuous space versions of CSO. The proposed BCSO was adapted to TSP and applied to a set of benchmark instances of symmetric TSP from the TSP library. The results of the proposed Binary Cockroach Swarm Optimization (BCSO) algorithm on TSP were compared to other meta-heuristic algorithms.
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Cancers, Vol. 8, Pages 83: Prospects in the Application of Photodynamic Therapy in Oral Cancer and Premalignant Lesions
Oral cancer is a global health burden with significantly poor survival, especially when the diagnosis is at its late stage. Despite advances in current treatment modalities, there has been minimal improvement in survival rates over the last five decades. The development of local recurrence, regional failure, and the formation of second primary tumors accounts for this poor outcome. For survivors, cosmetic and functional compromises resulting from treatment are often devastating. These statistics underscore the need for novel approaches in the management of this deadly disease. Photodynamic therapy (PDT) is a treatment modality that involves administration of a light-sensitive drug, known as a photosensitizer, followed by light irradiation of an appropriate wavelength that corresponds to an absorbance band of the sensitizer. In the presence of tissue oxygen, cytotoxic free radicals that are produced cause direct tumor cell death, damage to the microvasculature, and induction of inflammatory reactions at the target sites. PDT offers a prospective new approach in controlling this disease at its various stages either as a stand-alone therapy for early lesions or as an adjuvant therapy for advanced cases. In this review, we aim to explore the applications of PDT in oral cancer therapy and to present an overview of the recent advances in PDT that can potentially reposition its utility for oral cancer treatment.
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Sensors, Vol. 16, Pages 1418: A Disposable Microfluidic Device with a Screen Printed Electrode for Mimicking Phase II Metabolism
Human metabolism is investigated using several in vitro methods. However, the current methodologies are often expensive, tedious and complicated. Over the last decade, the combination of electrochemistry (EC) with mass spectrometry (MS) has a simpler and a cheaper alternative to mimic the human metabolism. This paper describes the development of a disposable microfluidic device with a screen-printed electrode (SPE) for monitoring phase II GSH reactions. The proposed chip has the potential to be used as a primary screening tool, thus complementing the current in vitro methods.
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Sensors, Vol. 16, Pages 1417: Using Custom Fiber Bragg Grating-Based Sensors to Monitor Artificial Landslides
Four custom fiber Bragg grating (FBG)-based sensors are developed to monitor an artificial landslide located in Nanjing, China. The sensors are composed of a rod and two FBGs. Based on the strength of the rods, two sensors are referred to as "hard sensors" (Sensor 1 and Sensor 2), the other two are referred to as "soft sensors" (Sensor 3 and Sensor 4). The two FBGs are fixed on each sensor rod at distances of 50 cm and 100 cm from the top of the rod (an upper FBG and a lower FBG). In the experiment presented in this paper, the sensors are installed on a slope on which an artificial landslide is generated through both machine-based and manual excavation. The fiber sensing system consists of the four custom FBG-based sensors, optical fiber, a static fiber grating demodulation instrument (SM125), and a PC with the necessary software. Experimental data was collected in the presence of an artificial landslide, and the results show that the lower FBGs are more sensitive than the upper FBGs for all four of the custom sensors. It was also found that Sensor 2 and Sensor 4 are more capable of monitoring small-scale landslides than Sensor 1 and Sensor 3, and this is mainly due to their placement location with respect to the landslide. The stronger rods used in the hard sensors make them more adaptable to the harsh environments of large landslides. Thus, hard sensors should be fixed near the landslide, while soft sensors should be placed farther away from the landslide. In addition, a clear tendency of strain variation can be detected by the soft sensors, which can be used to predict landslides and raise a hazard alarm.
http://ift.tt/2bOCAYQ
Fluids, Vol. 1, Pages 28: Eddy Backscatter and Counter-Rotating Gyre Anomalies of Midlatitude Ocean Dynamics
This work concerns how two competing mechanisms—eddy backscatter and counter-rotating gyre anomalies—influence the midlatitude ocean dynamics, as described by the eddy-resolving quasi-geostrophic (QG) model of wind-driven gyres. We analyzed dynamical balances and effects of different eddy forcing components, as well as their dependencies on increasing vertical resolution and decreasing eddy viscosity and found that the eastward jet and its adjacent recirculation zones are maintained mostly by the eddy forcing via the eddy backscatter mechanism, whereas the time-mean eddy-forcing component plays not only direct jet-supporting but also indirect jet-inhibiting role. The latter is achieved by inducing zonally elongated anticyclonic/cyclonic Counter-rotating Gyre Anomaly (CGA) in the subpolar/subtropical gyre. The indirect effect of CGAs on the eastward jet is found to be moderate relative to the dominant eddy backscatter mechanism. We also found that the higher the vertical baroclinic mode, the weaker its backscatter role and the stronger its CGA-driving role. Although the barotropic and first baroclinic modes are the most efficient ones in maintaining the backscatter, the higher, up to the fifth baroclinic modes also have significant but reverse impact that reduces the backscatter.
http://ift.tt/2bJaJfk
Marine Drugs, Vol. 14, Pages 159: Antimicrobial Compounds from Eukaryotic Microalgae against Human Pathogens and Diseases in Aquaculture
The search for novel compounds of marine origin has increased in the last decades for their application in various areas such as pharmaceutical, human or animal nutrition, cosmetics or bioenergy. In this context of blue technology development, microalgae are of particular interest due to their immense biodiversity and their relatively simple growth needs. In this review, we discuss about the promising use of microalgae and microalgal compounds as sources of natural antibiotics against human pathogens but also about their potential to limit microbial infections in aquaculture. An alternative to conventional antibiotics is needed as the microbial resistance to these drugs is increasing in humans and animals. Furthermore, using natural antibiotics for livestock could meet the consumer demand to avoid chemicals in food, would support a sustainable aquaculture and present the advantage of being environmentally friendly. Using natural and renewable microalgal compounds is still in its early days, but considering the important research development and rapid improvement in culture, extraction and purification processes, the valorization of microalgae will surely extend in the future.
http://ift.tt/2bOB1Ke
Life, Vol. 6, Pages 37: Bipyrimidine Signatures as a Photoprotective Genome Strategy in G + C-rich Halophilic Archaea
Halophilic archaea experience high levels of ultraviolet (UV) light in their environments and demonstrate resistance to UV irradiation. DNA repair systems and carotenoids provide UV protection but do not account for the high resistance observed. Herein, we consider genomic signatures as an additional photoprotective strategy. The predominant forms of UV-induced DNA damage are cyclobutane pyrimidine dimers, most notoriously thymine dimers (T^Ts), which form at adjacent Ts. We tested whether the high G + C content seen in halophilic archaea serves a photoprotective function through limiting T nucleotides, and thus T^T lesions. However, this speculation overlooks the other bipyrimidine sequences, all of which capable of forming photolesions to varying degrees. Therefore, we designed a program to determine the frequencies of the four bipyrimidine pairs (5' to 3': TT, TC, CT, and CC) within genomes of halophilic archaea and four other randomized sample groups for comparison. The outputs for each sampled genome were weighted by the intrinsic photoreactivities of each dinucleotide pair. Statistical methods were employed to investigate intergroup differences. Our findings indicate that the UV-resistance seen in halophilic archaea can be attributed in part to a genomic strategy: high G + C content and the resulting bipyrimidine signature reduces the genomic photoreactivity.
http://ift.tt/2bJar86
Sensors, Vol. 16, Pages 1412: Weak and Dynamic GNSS Signal Tracking Strategies for Flight Missions in the Space Service Volume
Weak-signal and high-dynamics are of two primary concerns of space navigation using GNSS (Global Navigation Satellite System) in the space service volume (SSV). The paper firstly defines a reference assumption third-order phase-locked loop (PLL) as the baseline of an onboard GNSS receiver, and proves the incompetence of this conventional architecture. Then an adaptive four-state Kalman filter (KF)-based algorithm is introduced to realize the optimization of loop noise bandwidth, which can adaptively regulate its filter gain according to the received signal power and line-of-sight (LOS) dynamics. To overcome the matter of losing lock in weak-signal and high-dynamic environments, an open loop tracking strategy aided by an inertial navigation system (INS) is recommended, and the traditional maximum likelihood estimation (MLE) method is modified in a non-coherent way by reconstructing the likelihood cost function. Furthermore, a typical mission with combined orbital maneuvering and non-maneuvering arcs is taken as a destination object to test the two proposed strategies. Finally, the experiment based on computer simulation identifies the effectiveness of an adaptive four-state KF-based strategy under non-maneuvering conditions and the virtue of INS-assisted methods under maneuvering conditions.
http://ift.tt/2bOBOuL
Societies, Vol. 6, Pages 27: Exploring the Daily Lives of People on Methadone Maintenance Treatment: An Occupational Perspective
A qualitative study was undertaken with five people on methadone maintenance treatment (MMT) to better understand their experiences and daily routines. Through an in-depth exploration of their everyday occupations, we sought to reveal the ongoing challenges and barriers they face to accessing treatment. The concept of occupation refers to 'all that people need, want and are required to do' but also extends further to encompass 'how doing contributes to processes of being, becoming and belonging' (Huot and Laliberte Rudman, 2015). This research employed a qualitative intrinsic case study methodology (Stake, 2005). Using an occupational perspective informed by a framework for occupational justice (Stadnyk et al., 2005), the participants' narratives are presented according to four themes highlighting key aspects of their experiences: (a) descent into chaos; (b) MMT as a bridge to recovery from addiction; (c) a new normal daily life; and (d) hopes for moving forward. The findings illustrate how structural factors and contextual factors interact to create occupational injustices. Thus, MMT practices and policies should consider the occupational implications described in this article to enhance patients' experiences and further support their recovery.
http://ift.tt/2bJ9Mnl
Sustainability, Vol. 8, Pages 877: Economic and Environmental Benefits of Optimized Hybrid Renewable Energy Generation Systems at Jeju National University, South Korea
In order to minimize the social and environmental concerns arising from the use of traditional energy resources such as fossil fuels and nuclear energy, the South Korean government has attempted to develop alternative energy resources. In particular, the large educational institutes and islands in South Korea—which have the motivation and potential to provide electrical services—are required to install renewable electricity generation facilities to reduce the burden on the local grid systems. With this trend, the current study investigates potential configurations of renewable electricity generation systems to supply the electrical demand of Jeju National University, located on the largest island in South Korea. The potential configurations suggested by the simulation results are evaluated by renewable fraction, cost of energy (COE), and total net present cost (NPC). The suggested configurations show a renewable fraction of 1.00 with COE of $0.356–$0.402 per kWh and NPC of $54,620,352–$51,795,040. Based on the results, both implications and limitations are examined.
http://ift.tt/2bOBMDo
Energies, Vol. 9, Pages 706: Radial Force-Current Characteristics Analysis of Three-Pole Radial-Axial Hybrid Magnetic Bearings and Their Structure Improvement
The radial stator of three-pole radial-axial hybrid magnetic bearings (HMB) has three magnetic poles and the three magnetic poles are driven by a three-phase converter, so the three-pole radial-axial HMB has the advantages of compact structure, low cost, low power consumption and so on. However, as the sum of three-phase current is zero and the three radial magnetic poles are asymmetric, the relationship between the radial suspension force and the control current is nonlinear. In this paper, firstly a mathematical model of three-pole radial-axial HMB is built based on the equivalent magnetic circuit method. The radial force-current characteristics are then analyzed based on the non-linearized model. The calculation, finite element method (FEM) and experimental results show that the suspension force on the x-axis is a quadratic function of the control current, but the suspension force on the y-axis is linear with control current. Besides, the suspension forces on the two radial axes are coupled with each other. Then, in order to decrease the nonlinearity and coupling of radial force-current characteristics, the six-pole radial-axial HMB is proposed based on the above analyses. The radial force-current characteristics of the six-pole radial-axial HMB are also analyzed based on the non-linearitzed model and are validated by 3-D FEM analysis. The calculation and FEM results have shown that the radial force-current relationship of a six-pole radial-axial HMB is linear and there is no coupling between the two radial axes.
http://ift.tt/2bJaNvE
Viruses, Vol. 8, Pages 244: A Decrease in Temperature and Humidity Precedes Human Rhinovirus Infections in a Cold Climate
Both temperature and humidity may independently or jointly contribute to the risk of human rhinovirus (HRV) infections, either through altered survival and spread of viruses in the environment or due to changes in host susceptibility. This study examined the relationship between short-term variations in temperature and humidity and the risk of HRV infections in a subarctic climate. We conducted a case-crossover study among conscripts (n = 892) seeking medical attention due to respiratory symptoms during their military training and identified 147 HRV cases by real-time PCR. An average temperature, a decline in daily ambient temperature and absolute humidity (AH) during the three preceding days of the onset (hazard period) and two reference periods (a week prior and after the onset) were obtained. The average daily temperature preceding HRV infections was −9.9 ± 4.9 °C and the average AH was 2.2 ± 0.9 g/m3. An average (odds ratios (OR) 1.07 (95% confidence interval (CI) 1.00–1.15)) and maximal (OR 1.08 (1.01–1.17)) change in temperature increased the risk of HRV infections by 8% per 1 °C decrease. An average (OR 1.20 (CI 1.03–1.40)) and maximal decrease (OR 1.13 (CI 0.96–1.34)) in AH increased the risk of HRV infection by 13% and 20% per 0.5 g/m3 decrease. A higher average temperature during the three preceding days was positively associated with HRV infections (OR 1.07 (CI 1.00–1.15)). A decrease rather than low temperature and humidity per se during the preceding few days increases the risk of HRV infections in a cold climate. The information is applicable to populations residing in cold climates for appropriate personal protection and prevention of adverse health effects.
http://ift.tt/2bOCgct
Vaccines, Vol. 4, Pages 29: Monitoring of the Immune Dysfunction in Cancer Patients
Immunotherapy shows promising clinical results in patients with different types of cancer, but its full potential is not reached due to immune dysfunction as a result of several suppressive mechanisms that play a role in cancer development and progression. Monitoring of immune dysfunction is a prerequisite for the development of strategies aiming to alleviate cancer-induced immune suppression. At this point, the level at which immune dysfunction occurs has to be established, the underlying mechanism(s) need to be known, as well as the techniques to assess this. While it is relatively easy to measure general signs of immune suppression, it turns out that accurate monitoring of the frequency and function of immune-suppressive cells is still difficult. A lack of truly specific markers, the phenotypic complexity among suppressive cells of the same lineage, but potentially with different functions and functional assays that may not cover every mechanistic aspect of immune suppression are among the reasons complicating proper assessments. Technical innovations in flow and mass cytometry will allow for more complete sets of markers to precisely determine phenotype and associated function. There is, however, a clear need for functional assays that recapitulate more of the mechanisms employed to suppress the immune system.
http://ift.tt/2bJbyog
Avoiding Routine Chest Radiography after Transbronchial Biopsy Is Safe
Respiration
http://ift.tt/2bVfRdW
Laser therapy for the treatment of pearly penile papules
Abstract
Pearly penile papules (PPP) present as dome-shaped papules of no more than 3 mm in diameter that line the base of the glans of the penis. These benign lesions affect between 14.3 and 48 % of men. While often asymptomatic, PPP can cause a great deal of psychological distress that may warrant treatment. Current treatment options include cryotherapy, electrodessication, and curettage (ED&C). However, these modalities may have considerable adverse cosmetic effects, including scarring, pain, and pigmentary changes. Laser modalities offer clear potential for improved cosmetic outcome in PPP treatment, but is not routinely used. Thus, a systematic review of available literature using the National Library of Medicine database PubMed was completed to find articles relevant to the treatment of PPP with laser and light therapy. The systematic search and screening of articles resulted in inclusion of eight articles discussing a total of 55 patients with PPP treated by laser therapy. The present systematic review found that erbium:yttrium-aluminum-garnet (Er:YAG) and CO2 laser were the most commonly reported (n = 45 and 7, respectively). Furthermore, the use of CO2, Er:YAG, pulsed dye laser, and fractional photothermolysis therapies demonstrated complete clearance of PPP in all cases with minimal complications and discomfort. Thus, based on the currently available evidence, laser therapy is a well-tolerated and efficacious method for treating PPP with minimal long-term adverse effects and a cosmetically desirable outcome. Although the included studies are limited in power, this systematic review offers clinically relevant insight into the potential for laser therapy.
http://ift.tt/2cvfiwC
Toxins, Vol. 8, Pages 258: Confirmation and Fine Mapping of a Major QTL for Aflatoxin Resistance in Maize Using a Combination of Linkage and Association Mapping
Maize grain contamination with aflatoxin from Aspergillus flavus (A. flavus) is a serious health hazard to animals and humans. To map the quantitative trait loci (QTLs) associated with resistance to A. flavus, we employed a powerful approach that differs from previous methods in one important way: it combines the advantages of the genome-wide association analysis (GWAS) and traditional linkage mapping analysis. Linkage mapping was performed using 228 recombinant inbred lines (RILs), and a highly significant QTL that affected aflatoxin accumulation, qAA8, was mapped. This QTL spanned approximately 7 centi-Morgan (cM) on chromosome 8. The confidence interval was too large for positional cloning of the causal gene. To refine this QTL, GWAS was performed with 558,629 single nucleotide polymorphisms (SNPs) in an association population comprising 437 maize inbred lines. Twenty-five significantly associated SNPs were identified, most of which co-localised with qAA8 and explained 6.7% to 26.8% of the phenotypic variation observed. Based on the rapid linkage disequilibrium (LD) and the high density of SNPs in the association population, qAA8 was further localised to a smaller genomic region of approximately 1500 bp. A high-resolution map of the qAA8 region will be useful towards a marker-assisted selection (MAS) of A. flavus resistance and a characterisation of the causal gene.
http://ift.tt/2bYial7
Technologies, Vol. 4, Pages 27: Dry Sliding Wear Behavior of Spark Plasma Sintered Fe-Based Bulk Metallic Glass/Graphite Composites
Bulk metallic glass (BMG) and BMG-graphite composites were fabricated using spark plasma sintering at the sintering temperature of 575 °C and holding time of 15 min. The sintered composites exhibited partial crystallization and the presence of distributed porosity and graphite particles. The effect of graphite reinforcement on the tribological properties of the BMG/graphite composites was investigated using dry ball-on-disc sliding wear tests. The reinforcement of graphite resulted in a reduction in both the wear rate and the coefficient of friction as compared to monolithic BMG samples. The wear surfaces of BMG/graphite composites showed regions of localized wear loss due to microcracking and fracture, as was also the case with the regions covered with graphite-rich protective film due to smearing of pulled off graphite particles.
http://ift.tt/2bYiZdq
Molecules, Vol. 21, Pages 1130: Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L.
The twigs of Morus alba L. were found to show strong tyrosinase inhibition activity, and the responsible active components in the extract were further investigated in this study. A flavone, named morusone (1), and sixteen known compounds 2–17 were isolated from M. alba twigs and their structures were identified by interpretation of the corresponding ESI-MS and NMR spectral data. In the tyrosinase inhibitory test, the compounds steppogenin (IC50 0.98 ± 0.01 µM), 2,4,2′,4′-tetrahydroxychalcone (IC50 0.07 ± 0.02 µM), morachalcone A (IC50 0.08 ± 0.02 µM), oxyresveratrol (IC50 0.10 ± 0.01 µM), and moracin M (8.00 ± 0.22 µM) exhibited significant tyrosinase inhibition activities, much stronger than that of the positive control kojic acid. These results suggest that M. alba twig extract should served as a good source of natural tyrosinase inhibitors for use in foods as antibrowning agents or in cosmetics as skin-whitening agents.
http://ift.tt/2bOMsDh
Toxins, Vol. 8, Pages 258: Confirmation and Fine Mapping of a Major QTL for Aflatoxin Resistance in Maize Using a Combination of Linkage and Association Mapping
Maize grain contamination with aflatoxin from Aspergillus flavus (A. flavus) is a serious health hazard to animals and humans. To map the quantitative trait loci (QTLs) associated with resistance to A. flavus, we employed a powerful approach that differs from previous methods in one important way: it combines the advantages of the genome-wide association analysis (GWAS) and traditional linkage mapping analysis. Linkage mapping was performed using 228 recombinant inbred lines (RILs), and a highly significant QTL that affected aflatoxin accumulation, qAA8, was mapped. This QTL spanned approximately 7 centi-Morgan (cM) on chromosome 8. The confidence interval was too large for positional cloning of the causal gene. To refine this QTL, GWAS was performed with 558,629 single nucleotide polymorphisms (SNPs) in an association population comprising 437 maize inbred lines. Twenty-five significantly associated SNPs were identified, most of which co-localised with qAA8 and explained 6.7% to 26.8% of the phenotypic variation observed. Based on the rapid linkage disequilibrium (LD) and the high density of SNPs in the association population, qAA8 was further localised to a smaller genomic region of approximately 1500 bp. A high-resolution map of the qAA8 region will be useful towards a marker-assisted selection (MAS) of A. flavus resistance and a characterisation of the causal gene.
http://ift.tt/2bYial7
Molecules, Vol. 21, Pages 1166: Single-Walled Carbon-Nanotubes-Based Organic Memory Structures
The electrical behaviour of organic memory structures, based on single-walled carbon-nanotubes (SWCNTs), metal–insulator–semiconductor (MIS) and thin film transistor (TFT) structures, using poly(methyl methacrylate) (PMMA) as the gate dielectric, are reported. The drain and source electrodes were fabricated by evaporating 50 nm gold, and the gate electrode was made from 50 nm-evaporated aluminium on a clean glass substrate. Thin films of SWCNTs, embedded within the insulating layer, were used as the floating gate. SWCNTs-based memory devices exhibited clear hysteresis in their electrical characteristics (capacitance–voltage (C–V) for MIS structures, as well as output and transfer characteristics for transistors). Both structures were shown to produce reliable and large memory windows by virtue of high capacity and reduced charge leakage. The hysteresis in the output and transfer characteristics, the shifts in the threshold voltage of the transfer characteristics, and the flat-band voltage shift in the MIS structures were attributed to the charging and discharging of the SWCNTs floating gate. Under an appropriate gate bias (1 s pulses), the floating gate is charged and discharged, resulting in significant threshold voltage shifts. Pulses as low as 1 V resulted in clear write and erase states.
http://ift.tt/2bONX4x
Galaxies, Vol. 4, Pages 22: Spectral and Polarization Signatures of Relativistic Shocks in Blazars
Relativistic shocks are one of the most plausible sites of the emission of strongly variable, polarized multi-wavelength emission from relativistic jet sources such as blazars, via the diffusive shock acceleration (DSA) of relativistic particles. This paper summarizes recent results on a self-consistent coupling of diffusive shock acceleration and radiation transfer in blazar jets. We demonstrate that the observed spectral energy distributions (SEDs) of blazars strongly constrain the nature of hydromagnetic turbulence responsible for pitch-angle scattering by requiring a strongly energy-dependent pitch-angle mean free path. The prominent soft X-ray excess ("Big Blue Bump") in the SED of the BL Lac object AO 0235+164 can be modelled as the signature of bulk Compton scattering of external radiation fields by the thermal electron population, which places additional constraints on the level of hydromagnetic turbulence. It has further been demonstrated that internal shocks propagating in a jet pervaded by a helical magnetic field naturally produce polarization-angle swings by 180 ∘ , in tandem with multi-wavelength flaring activity, without requiring any helical motion paths or other asymmetric jet structures. The specific application of this model to 3C279 presents the first consistent simultaneous modeling of snap-shot SEDs, multi-wavelength light curves, and time-dependent polarization signatures of a blazar during a polarization-angle (PA) rotation. This model has recently been generalized to a lepto-hadronic model, in which the high-energy emission is dominated by proton synchrotron radiation. It is shown that in this case, the high-energy (X-ray and γ-ray) polarization signatures are expected to be significantly more stable (not showing PA rotations) than the low-energy (electron-synchrotron) signatures.
http://ift.tt/2bYj9lm
Insects, Vol. 7, Pages 44: Efficacy of Controlled Atmosphere Treatments to Manage Arthropod Pests of Dry-Cured Hams
Research here explored the use of controlled atmospheres (CA) for managing arthropod pests that infest dry-cured hams. Experiments were conducted with low oxygen (O2) achieved with low pressure under a vacuum, high carbon dioxide (CO2), and ozone (O3). Results showed that both low O2 and high CO2 levels required exposures up to 144 h to kill 100% of all stages of red-legged ham beetle, Necrobia rufipes (De Geer) (Coleoptera: Cleridae) and ham mite Tyrophagus putrescentiae (Schrank) (Sarcoptiformes: Acaridae) at 23 °C. In addition, both low O2 and high CO2 had no significant mortality against the ham beetle and ham mites at short exposures ranging from 12 to 48 h. Ham beetles were more tolerant than ham mites to an atmosphere of 75.1% CO2 and low pressure of 25 mm Hg, which imposed an atmosphere estimated at 0.9% O2. Both low O2 and high CO2 trials indicated that the egg stages of both species were more tolerant than other stages tested, but N. rufipes eggs and pupae were more susceptible than larvae and adults to high concentration ozone treatments. The results indicate that O3 has potential to control ham beetles and ham mites, particularly at ≈166 ppm in just a 24 h exposure period, but O3 is known from other work to have poor penetration ability, thus it may be more difficult to apply effectively than low O2 or high CO2. would be. CA treatment for arthropod pests of dry-cured hams show promise as components of integrated pest management programs after methyl bromide is no longer available for use.
http://ift.tt/2bOMMlB
JCM, Vol. 5, Pages 78: Real World Experiences: Pirfenidone and Nintedanib are Effective and Well Tolerated Treatments for Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis (IPF) now has two licensed treatments available. Pirfenidone was the first drug to be licensed and approved for use, followed by nintedanib. We set out our real world experience with these agents in terms of their adverse events profile outside the restrictions of a clinical trial. We have demonstrated in the real world setting, that side effects are common and predominantly gastrointestinal with both therapies. Our study shows that the side effects can be effectively managed in the majority of patients with an acceptable discontinuation rate similar to that seen in the clinical trials. These findings are compelling despite the fact that the patients in our study are older, have severer disease as depicted by baseline lung function and more co-morbidities. Our data provides ongoing evidence of the safety and tolerability of both pirfenidone and nintedanib in patients who would not have met the rigorous criteria to be included in a clinical trial. Both these agents are effective in the management of IPF and slow the progression of this debilitating life limiting condition.
http://ift.tt/2bYioc1
Energies, Vol. 9, Pages 707: Exergy Analysis of the Supply of Energy and Material Resources in the Swedish Society
Exergy is applied to the Swedish energy supply system for the period 1970–2013. Exergy flow diagrams for the systems of electricity and district heating as well as for the total supply system of energy and material resources for 2012 are presented. The share of renewable use has increased in both electricity and district heat production. The resource use is discussed in four sectors: residential and service, transportation, industry and agriculture. The resource use is also analyzed with respect to exergy efficiency and renewable share. The total exergy input of energy and material resources amounts to about 2700 PJ of which about 530 PJ was used for final consumption in 2012. The results are also compared with similar studies. Even though the share of renewable resource use has increased from 42% in 1980 to 47% in 2012, poor efficiency is still occurring in transportation, space heating, and food production. A strong dependence on fossil and nuclear fuels also implies a serious lack of sustainability. A more exergy efficient technology and a higher renewable energy share are needed in order to become a more sustainable society.
http://ift.tt/2bOMLOz
Coatings, Vol. 6, Pages 38: Coatings Best Paper Award 2016
Coatings has established the Best Paper Award to recognize its best published articles each year.[...]
http://ift.tt/2bYj8Ok
Technologies, Vol. 4, Pages 28: Psychosocial Impact of Assistive Technologies for Mobility and Their Implications for Active Ageing
Purpose: Active ageing is defined as the process of optimizing opportunities for physical, social and mental health to enable older people to actively take part in society without discrimination and to enjoy independence and good quality of life. The World Health Organization assumed this to be a process for increasing and maintaining an individual's participation in activities to enhance his/her quality of life. In this survey, the authors addressed the following question: is assistive technology (AT) for mobility contributing to enhancement of lifelong capacity and performance? Method: From June 2015 until February 2016, 96 community dwelling adults, AT users for mobility (powered wheelchairs, manual wheelchairs, lower limb prostheses, walkers, crutches and canes), aged 45–97, mean 67.02 ± 14.24 years old, 56.3% female, were interviewed using the Psychosocial Impact of Assistive Devices Scale (P-PIADS), the Activities and Participation Profile related to Mobility (APPM) and demographics, clinical and questions about AT use and training. Results and Discussion: The participants' profiles revealed moderate limitation and restrictions in participation, measured by the APPM (2.03). Most participants displayed a positive impact from AT; average scores obtained from the P-PIADS subscales were: Self-esteem 0.62, Competency 1.11 and Adaptability 1.10. The P-PIADS total was 0.96, with the powered wheelchair users scoring the highest (1.53) and the walker users scoring the lowest (0.73). All subscales and the P-PIADS total were positively correlated with the activities and participation profile. There was no relation between age and the psychosocial impact of AT or activities and participation profile. These results encourage the authors to follow up with these participants for a lifelong intervention. To accomplish that aim, currently, the protocol is implemented at the AT prescribing centers in Coimbra, Portugal in order to assess the impact of AT on participation in society, one of the domains of the Active Ageing Index, a new analytical tool to help policy makers in developing policies for active and healthy ageing.
http://ift.tt/2bONTBP
Toxics, Vol. 4, Pages 20: Assessment of Toxicological Perturbations and Variants of Pancreatic Islet Development in the Zebrafish Model
The pancreatic islets, largely comprised of insulin-producing beta cells, play a critical role in endocrine signaling and glucose homeostasis. Because they have low levels of antioxidant defenses and a high perfusion rate, the endocrine islets may be a highly susceptible target tissue of chemical exposures. However, this endpoint, as well as the integrity of the surrounding exocrine pancreas, is often overlooked in studies of developmental toxicology. Disruption of development by toxicants can alter cell fate and migration, resulting in structural alterations that are difficult to detect in mammalian embryo systems, but that are easily observed in the zebrafish embryo model (Danio rerio). Using endogenously expressed fluorescent protein markers for developing zebrafish beta cells and exocrine pancreas tissue, we documented differences in islet area and incidence rates of islet morphological variants in zebrafish embryos between 48 and 96 h post fertilization (hpf), raised under control conditions commonly used in embryotoxicity assays. We identified critical windows for chemical exposures during which increased incidences of endocrine pancreas abnormalities were observed following exposure to cyclopamine (2–12 hpf), Mono-2-ethylhexyl phthalate (MEHP) (3–48 hpf), and Perfluorooctanesulfonic acid (PFOS) (3–48 hpf). Both islet area and length of the exocrine pancreas were sensitive to oxidative stress from exposure to the oxidant tert-butyl hydroperoxide during a highly proliferative critical window (72 hpf). Finally, pancreatic dysmorphogenesis following developmental exposures is discussed with respect to human disease.
http://ift.tt/2bYiKPC
Energies, Vol. 9, Pages 699: Numerical Modeling and Investigation of Fluid-Driven Fracture Propagation in Reservoirs Based on a Modified Fluid-Mechanically Coupled Model in Two-Dimensional Particle Flow Code
Hydraulic fracturing is a useful tool for enhancing rock mass permeability for shale gas development, enhanced geothermal systems, and geological carbon sequestration by the high-pressure injection of a fracturing fluid into tight reservoir rocks. Although significant advances have been made in hydraulic fracturing theory, experiments, and numerical modeling, when it comes to the complexity of geological conditions knowledge is still limited. Mechanisms of fluid injection-induced fracture initiation and propagation should be better understood to take full advantage of hydraulic fracturing. This paper presents the development and application of discrete particle modeling based on two-dimensional particle flow code (PFC2D). Firstly, it is shown that the modeled value of the breakdown pressure for the hydraulic fracturing process is approximately equal to analytically calculated values under varied in situ stress conditions. Furthermore, a series of simulations for hydraulic fracturing in competent rock was performed to examine the influence of the in situ stress ratio, fluid injection rate, and fluid viscosity on the borehole pressure history, the geometry of hydraulic fractures, and the pore-pressure field, respectively. It was found that the hydraulic fractures in an isotropic medium always propagate parallel to the orientation of the maximum principal stress. When a high fluid injection rate is used, higher breakdown pressure is needed for fracture propagation and complex geometries of fractures can develop. When a low viscosity fluid is used, fluid can more easily penetrate from the borehole into the surrounding rock, which causes a reduction of the effective stress and leads to a lower breakdown pressure. Moreover, the geometry of the fractures is not particularly sensitive to the fluid viscosity in the approximate isotropic model.
http://ift.tt/2bONi3h
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Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
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heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
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