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AntibioticsAntibiotics, Vol. 9, Pages 21: Host-Directed Therapy as a Novel Treatment Strategy to Overcome Tuberculosis: Targeting Immune ModulationAntibiotics, Vol. 9, Pages 21: Host-Directed Therapy as a Novel Treatment Strategy to Overcome Tuberculosis: Targeting Immune Modulation Antibiotics doi: 10.3390/antibiotics9010021 Authors: Ahmed Raqib Guðmundsson Bergman Agerberth Rekha Tuberculosis (TB) is one of the leading causes of mortality and morbidity, particularly in developing countries, presenting...
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Prognostic significance of lactate dehydrogenase in cabazitaxel chemotherapy for castration-resistant prostate cancer: a multi-institutional study: Objective This multi-institutional study aimed to identify prognostic factors for cabazitaxel treatment of castration-resistant prostate cancer (CRPC).Methods This study included 74 Japanese patients with CRPC who were treated with cabazitaxel between 2014 and 2017. Associations between clinicopathological factors including serum markers and progression-free...
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A novel bis-aryl urea compound inhibits tumor proliferation via cathepsin D-associated apoptosis: Derivatives of bis-aryl urea have been widely investigated for their various biological activities, such as antiviral, anti-inflammatory and antiproliferative. We evaluated a new chemical entity consisting of bis-aryl urea moiety, N69B, for its anticancer activities and explored their underlying molecular mechanism. The compound inhibited proliferation of multiple types of murine and human cancer cells...
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A metanalysis on cabozantinib and bone metastases: true story or commercial gimmick?: Is it true that cabozantinib should be the preferred option treating patients with bone metastases? Are there any reliable comparisons between this drug and other standard options in this subgroup? To address the issue, we performed a systematic review and metanalysis of randomized trials with cabozantinib, to assess its effectiveness, in terms of overall survival, according to the presence of bone metastases. We...
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Clinical efficacy of irinotecan plus raltitrexed chemotherapy in refractory esophageal squamous cell cancer: Purpose Our retrospective study assessed the efficacy and safety of irinotecan plus raltitrexed in esophageal squamous cell cancer (ESCC) patients who were previously treated with multiple systemic therapies.Methods Between January 2016 and December 2018, records of 38 ESCC patients who underwent irinotecan plus raltitrexed chemotherapy after at least one line of chemotherapy were reviewed....
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miR-7641 depletion suppresses proliferation of gastric cancer cells by targeting ARID1A: Gastric cancer (GC) is lethal and there is an urgent need for improved understanding of this disease. Recent studies have reported that microRNAs (miRNAs) play increasingly important roles in the regulation of GC. In this study, we explored the target genes and effects of miR-7641 in GC. Our data showed that high miR-7641 expression was associated with low expression of ARID1A in GC tissue. miR-7641 expression...
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Combination treatment of bicalutamide and curcumin has a strong therapeutic effect on androgen receptor-positive triple-negative breast cancers: Triple-negative breast cancers account for approximately 15–20% of breast cancer patients. Due to lack of expression of estrogen receptor, PR and human epidermal growth factor receptor 2 in triple-negative breast cancers, there are no targeted therapies available for these cancers. Therefore, a major research priority is to find potential therapeutic targets....
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A pre-existing population of ZEB2 + quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer: AbstractBackgroundQuiescent/slow cycling cells have been identified in several tumors and correlated with therapy resistance. However, the features of chemoresistant populations and the molecular factors linking quiescence to chemoresistance are largely unknown.MethodsA population of chemoresistant quiescent/slow cycling cells was isolated through PKH26 staining...
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Downregulation of lncRNA HOTTIP Suppresses the Proliferation, Migration, and Invasion of Oral Tongue Squamous Cell Carcinoma by Regulation of HMGA2-Mediated Wnt/β-Catenin Pathway: Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. AbstractBackground: Oral tongue squamous cell carcinoma (OTSCC) is a common type of oral tumor. LncRNAs (long noncoding RNAs) and miRNAs (microRNAs) were identified as regulators in many human cancers. This study aims to explore the molecular basis of HOXA transcript...
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10D1F, an Anti-HER3 Antibody that Uniquely Blocks the Receptor Heterodimerization Interface, Potently Inhibits Tumor Growth Across a Broad Panel of Tumor Models: In recent years, HER3 has increasingly been implicated in the progression of a variety of tumor types and in acquired resistance to EGFR and HER2 therapies. Whereas EGFR and HER2 primarily signal through the MAPK pathway, HER3, as a heterodimer with EGFR or HER2, potently activates the PI3K pathway. Despite its critical role, previous attempts...
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Regulatory T cell depletion alters the tumor microenvironment and accelerates pancreatic carcinogenesis. [Research Articles]: Regulatory T cells (Tregs) are abundant ion human and mouse pancreatic cancer. To understand the contribution to the immunosuppressive microenvironment, we depleted Tregs in a mouse model of pancreatic cancer. Contrary to our expectations, Treg depletion failed to relieve immunosuppression, and led to accelerated tumor progression. We show that Tregs are a key source of TGFβ...
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Efficacy of FGFR inhibitors and combination therapies for acquired resistance in FGFR2-fusion cholangiocarcinoma: The fibroblast growth factor receptor (FGFR) signaling pathway is aberrantly activated in approximately 15-20% of intrahepatic cholangiocarcinoma patients. Currently, several FGFR kinase inhibitors are being assessed in clinical trials for patients with FGFR-altered cholangiocarcinoma. Despite evidence of initial responses and disease control, virtually all patients eventually develop...
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Racial Differences in the Association between Luminal Master Regulator Gene Expression Levels and Breast Cancer Survival: Purpose: Compared to their European American (EA) counterparts, African American (AA) women are more likely to die from breast cancer in the United States. This disparity is greatest in hormone receptor-positive subtypes. Here we uncover biological factors underlying this disparity by comparing functional expression and prognostic significance of master transcriptional regulators...
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Tumor Analyses Reveal Squamous Transformation and Off-Target Alterations As Early Resistance Mechanisms to First-line Osimertinib in EGFR-Mutant Lung Cancer: Purpose: Patterns of resistance to first-line osimertinib are not well-established and have primarily been evaluated using plasma assays which cannot detect histologic transformation and have differential sensitivity for copy number changes and chromosomal rearrangements. Experimental Design: To characterize mechanisms of resistance to osimertinib,...
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LncRNA MAGI2-AS3 Upregulates Cytokine Signaling 1 by Sponging miR-155 in Non-Small Cell Lung Cancer: Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. AbstractBackground:MAGI2-AS3 has been reported to be a tumor suppressor in breast cancer and bladder cancer. This study analyzed the role of MAGI2-AS3 in non-small cell lung cancer (NSCLC).Results: The authors found that MAGI2-AS3 and suppressor of cytokine signaling 1 (SOCS-1) were both downregulated in NSCLC. MAGI2-AS3 and SOCS-1 were significantly...
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Multifactorial deep learning reveals pan-cancer genomic tumor clusters with distinct immunogenomic landscape and response to immunotherapy: Background: Tumor genomic features have been of particular interest because of their potential impact on the tumor immune microenvironment and response to immunotherapy. Due to the substantial heterogeneity, an integrative approach incorporating diverse molecular features is needed to characterize immunological features underlying primary resistance to immunotherapy...
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Characterization of Immune Dysfunction and Identification of Prognostic Immune-related Risk Factors in Acute Myeloid Leukemia: Purpose: This study aims to provide comprehensive insights into longitudinal immune landscape in acute myeloid leukemia (AML) development and treatment, which may contribute to predict prognosis and guide clinical decisions. Experimental Design: Periphery blood samples from 79 AML patients (at diagnosis or/and after chemotherapy or at relapse) and 24 healthy controls were...
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Phase I Study of Yttrium-90 Radiolabeled M5A Anti-Carcinoembryonic Antigen Humanized Antibody in Patients with Advanced Carcinoembryonic Antigen Producing Malignancies: Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. AbstractBackground: M5A is a humanized monoclonal antibody (mAb) directed against carcinoembryonic antigen (CEA) The purpose of this first in human phase I dose-escalation trial was to characterize the toxicities and determine the maximum tolerated dose (MTD) of yttrium-90...
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Risk factors and predictive model of diarrhoea among patients with severe stroke.: Risk factors and predictive model of diarrhoea among patients with severe stroke.World Neurosurg. 2019 Dec 31;:Authors: Xiang Y, Li F, Peng J, Qin D, Yuan M, Liu GAbstract AIMS: To investigate the risk factors and predictive model of diarrhoea among patients with severe stroke. METHODS: The study analysed the retrospective clinical data of patients with new-onset stroke who had been admitted to the intensive...
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Surgical Treatment of an Intracranial Anterior Ethmoidal Aneurysm: Case Report, Literature Review and Surgical Video.: Surgical Treatment of an Intracranial Anterior Ethmoidal Aneurysm: Case Report, Literature Review and Surgical Video.World Neurosurg. 2019 Dec 31;:Authors: Zervos TM, Mg TM, Zakaria H, Hlaing K, Aung TH, Myaing W, Rock JAbstract BACKGROUND: Anterior ethmoid aneurysms are rare with five cases of intracranial rupture and three cases of life-threatening epistaxis described in...
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Microsurgical Management of Ventral Intradural-Extramedullary Cervical Meningiomas: Technical Considerations and Outcomes.: Microsurgical Management of Ventral Intradural-Extramedullary Cervical Meningiomas: Technical Considerations and Outcomes.World Neurosurg. 2019 Dec 31;:Authors: Eroglu U, Bahadır B, Tomlinson S, Ugur HC, Sayaci EY, Attar A, Caglar YS, Cohen Gadol AAAbstract OBJECTIVE: Cervical meningiomas are uncommon intradural-extramedullary tumors that have a tendency to be situated...
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Dissection of the vertebral artery fenestration limb presenting with occlusion following rupture: a case report.: Dissection of the vertebral artery fenestration limb presenting with occlusion following rupture: a case report.World Neurosurg. 2019 Dec 31;:Authors: Ikeda H, Sano N, Torikoshi S, Otsuka R, Tsujimoto Y, Yamashita T, Hayase M, Toda HAbstract BACKGROUND: Dissection of a vertebral artery (VA) fenestration is extremely rare. We herein present the first case of a patient who presented...
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A multi-institutional analysis of factors influencing surgical outcomes for patients with newly diagnosed grade I gliomas.: A multi-institutional analysis of factors influencing surgical outcomes for patients with newly diagnosed grade I gliomas.World Neurosurg. 2019 Dec 31;:Authors: Yahanda AT, Patel B, Sutherland G, Honeycutt J, Jensen RL, Smyth MD, Limbrick DD, Dacey RG, Dowling JL, Dunn GP, Kim AH, Leuthardt EC, Rich KM, Zipfel GJ, Leonard JR, Cahill DP, Shah MV, Abram SR, Evans J, Tao Y, Chicoine...
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Transblepharo-preseptal modified orbitozygomatic approach for resection of a giant frontal cavernous malformation: 3-dimensional operative video.: Transblepharo-preseptal modified orbitozygomatic approach for resection of a giant frontal cavernous malformation: 3-dimensional operative video.World Neurosurg. 2019 Dec 31;:Authors: Rutkowski MJ, Ravina K, Carey JN, Russin JJAbstract A previously healthy 44-year-old woman presented with a first-time seizure. Magnetic resonance imaging (MRI) revealed...
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Side-to-end hypoglossal-facial neurorrhaphy for treatment of complete and irreversible facial paralysis after vestibular schwannoma removal by means of a retrosigmoid approach: A clinical and anatomical study.: Side-to-end hypoglossal-facial neurorrhaphy for treatment of complete and irreversible facial paralysis after vestibular schwannoma removal by means of a retrosigmoid approach: A clinical and anatomical study.World Neurosurg. 2020 Jan 02;:Authors: González-Darder JM, Capilla-Guasch P, Escartín...
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