https://www.patientaccess.com/coronavirus?iitt=VksrRfn-4uPuh.e_4knAhFxdbCll4IQNtfeLb.1AOf4LOkes4.1Dhun7&utm_source=exponea&utm_campaign=PI%20Covid-19%20service%20update&utm_medium=emailCOVID-19 service updateHi ,At the core of our purpose here at Patient lie two fundamental objectives:To educate people on how to stay healthy and recover from illness or injury.To provide people with easy access to healthcare services.With the global outbreak of COVID-19 we find ourselves in unprecedented...
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Modeling phylogenetic biome shifts on a planet with a past [NEW RESULTS]: The spatial distribution of biomes has changed considerably over deep time, so the geographical opportunity for an evolutionary lineage to shift into a new biome may depend on how the availability and connectivity of biomes has varied temporally. To better understand how lineages shift between biomes in space and time, we developed a phylogenetic biome shift model in which each lineage shifts between biomes and disperses between...
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Emergence and diversification of a highly invasive chestnut pathogen lineage across south-eastern Europe [NEW RESULTS]: Invasive microbial species constitute a major threat to biodiversity, agricultural production and human health. Invasions are often dominated by one or a small number of genotypes, yet the underlying factors driving invasions are poorly understood. The chestnut blight fungus Cryphonectria parasitica first decimated the American chestnut and a recent outbreak threatens European chestnut...
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Expression of Concern: CD147, MMP-2, MMP-9 and MVD-CD34 are significant predictors of recurrence after liver transplantation in hepatocellular carcinoma patients: .
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Optical Coherence Tomography in the Evaluation of the Scalp and Hair: Common Features and Clinical Utility: Background and ObjectiveEarly diagnosis and treatment of hair loss disorders is vital in providing patients with improved psychological outcomes. Non‐invasive imaging with optical coherence tomography (OCT) may be useful in characterizing and managing alopecia. Despite expanding clinical applications of OCT in dermatology, guidelines demonstrating in vivo features of normal and alopecic scalp...
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Comprehensive single institute experience with melanoma TIL: Long term clinical results, toxicity profile, and prognostic factors of response: AbstractAdoptive cell transfer (ACT) of tumor‐infiltrating lymphocytes (TIL) mediates objective responses in 30% to 50% of patients with metastatic melanoma according to multiple, small phase 2 trials. Here we report the long‐term clinical results, intent‐to‐treat analysis, predictors of response and toxicity profile in a large patient cohort. A total of 179...
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Inhibition of Cathepsin D (CTSD) enhances radiosensitivity of glioblastoma cells by attenuating autophagy: AbstractPostoperative radiotherapy combined with chemotherapy is a commonly used treatment for glioblastoma (GBM) but radiotherapy often fails to achieve the expected results mainly due to tumor radioresistance. In this study, we established a radioresistant subline from human glioma cell line U251 and found that Cathepsin D (CTSD), a gene closely related to the clinical malignancy and prognosis...
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Spatiotemporal association patterns in a supergroup of Rwenzori black‐and‐white colobus (Colobus angolensis ruwenzorii) are consistent with a multilevel society: Progression capturing 141 individuals on August 17, 2017, with a duration of 01:01:12 hh:mm:ss (calculated optimal window size Δ = 228 s, 141 nodes; mothers and infants separated to individual nodes following analysis for better visualization of group composition; modularity score = 0.891). Dark blue nodes denote adult males, light blue...
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Pulmonary Malakoplakia by Rhodococcus equi in an HIV-Infected Patient in Mexico: A Case Report: Background. Rhodococcus equi-related pulmonary malakoplakia is a rare condition with few reported cases; hereby, we present a case associated with advanced human immunodeficiency virus (HIV) infection, and thus far to our knowledge, the first report in Mexico. It is estimated that approximately 10% of the infections occur in immunocompetent patients, whereas the rest are immune deficient, targeting virtually...
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Integrated mRNA and microRNA transcriptome profiling during Differentiation of Human Nasal Polyp Epithelium reveals an altered Ciliogenesis: AbstractBackgroundHuman adult basal stem/progenitor cells (BSCs) obtained from chronic rhinosinusitis with nasal polyps (CRSwNP) when differentiated in an air‐liquid interface (ALI) usually provide a pseudostratified airway epithelium with similar abnormalities than original in vivo phenotype. However, the intrinsic mechanisms regulating this complex process...
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Past, present and future of anti‐IgE biologicals: AbstractAbout 20 years after the identification of immunoglobulin E (IgE) and its key role in allergic hypersensitivity reactions against normally harmless substances, scientists have started inventing strategies to block its pathophysiological activity in 1986. The initial concept of specific IgE targeting through the use of anti‐IgE antibodies has gained a lot of momentum and within a few years independent research groups have reported successful...
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Epicutaneous sensitization in the development of food allergy: what is the evidence and how can this be prevented?: AbstractThere is increasing evidence regarding the importance of allergic sensitization through the skin. In this review, we provide an overview of the atopic march and immune mechanism underlying the sensitization and effector phase of food allergy. We present experimental models and human data that supports the concept of epicutaneous sensitization and how this forms one half of the...
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The nucleus accumbens and inhibition in the ventral tegmental area play a causal role in the Kamin blocking effect: AbstractThe discovery of Kamin blocking led to the idea that associative learning occurs only when there is a mismatch between actual and predicted outcomes, or prediction error. The neural substrates involved in regulating this prediction error during behavioral learning are still not fully elucidated. We investigated in rats the role of the ventral tegmental area and the nucleus accumbens...
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Understanding the spread of de novo and transmitted macrolide-resistance in Mycoplasma genitalium: Background The rapid spread of azithromycin resistance in sexually transmitted Mycoplasma genitalium infections is a growing concern. It is not yet clear to what degree macrolide resistance in M. genitalium results from the emergence of de novo mutations or the transmission of resistant strains. Methods We developed a compartmental transmission model to...
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Rock sponges (lithistid Demospongiae) of the Northeast Atlantic seamounts, with description of ten new species: Background Lithistid demosponges, also known as rock sponges, are a polyphyletic group of sponges which are widely distributed. In the Northeast Atlantic (NEA), 17 species are known and the current knowledge on their distribution is mainly restricted to the Macaronesian islands. In the Mediterranean Sea, 14 species are recorded and generally found in marine caves. Methods Lithistids...
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What's in a synonym? A nose by any other name would smell: ABSTRACTCommunication in the biomedical sciences and clinical practice would be clearer if everyone used the same set of technical terms. Creation of technical vocabularies, such as international standard terminologies, are attempts to avoid common linguistic problems, such as synonymy (many names for a single entity) and polysemy (many meanings for a single term). Efforts made in human anatomy since the late 19th century to deal with these...
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Reconstruction of an upper lip and intraoral defect following resection of an upper lip melanoma using a lower lip musculomucosal flap combined with a tongue flap: AbstractRestoring the cosmetic and functional aspects of the lip after tumor resection is challenging. We report a case of reconstruction for a defect due to resection of a melanoma using a lower lip musculomucosal flap combined with a tongue flap. A 20-year-old man was referred to our hospital and diagnosed with malignant melanoma with...
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Ischemic appendicitis due to pelvic adhesions: a case report: AbstractAcute appendicitis is one of the most common etiologies of a surgical abdomen. The lifetime risk is estimated to be 7%. Over 300 000 appendectomies occur annually in the USA. The pathophysiology of appendicitis in most patients is believed to be caused by outflow obstruction of the appendiceal lumen leading to increased intraluminal pressure, venous congestion and mucosal ischemia. This can occur due to a variety of internal obstructive...
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EBV-associated mucocutaneous ulcer, a rare cause of a frequent problem: AbstractThis report presents a 74-year-old renal transplant patient suffering of polymorphic-post-transplant-associated lymphoproliferative disease (P-PTLD) within an Eppstein-Barr Virus (EBV) associated mucocutaneous rectal ulcer (MCU). He was initially treated by stapled hemorrhoidopexy for a symptomatic grade III hemorrhoidal prolapse refractory to conservative treatment and rubber band ligations. This leads to severe urge,...
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Scrotal abscess after a perforated appendicitis: AbstractAlthough perforated appendicitis in pediatric patients can result in a diverse array of complications, scrotal abscess is a rarely documented phenomenon. We present a case of acute scrotum after laparoscopic appendectomy. A retrospective review of prior literature on scrotal abscess secondary to perforated appendicitis was performed via PubMed to review the clinical presentation, etiology, type of treatment and outcome of pediatric patients....
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Silent burn: the hidden danger and effects of bright light from fibre-optic cables in arthroscopic knee surgery: AbstractFollowing an uneventful arthroscopic menisectomy of the right knee, a white circular skin lesion, 1 cm in diameter, was noted on the anterior left thigh of a 23-year-old patient. The overlying paper surgical drape had not ignited nor produced smoke. Close inspection revealed a minute perforation in the drape with slight discolouration. No electro-cautery, radio-ablation or irritant...
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Clear cell adenocarcinoma arising from the abdominal wall after cesarean section in a patient with uterine adenomyosis: AbstractMalignant transformation of abdominal wall endometriosis lesions developed in a cesarean section scar is a rare event. Patients with uterine adenomyosis but without endometriosis can also develop abdominal wall malignant carcinoma after a gynecologic surgery. The treatment of abdominal wall clear cell adenocarcinoma combines tumor surgical excision with free margins, radiotherapy...
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Fibroadenoma containing lobular carcinoma in situ, an unusual finding in a normally benign mass: AbstractThis is the case of a 27-year-old female who underwent breast lumpectomy for fibroadenoma of the left breast. Pathologic evaluation of the specimen revealed lobular carcinoma in situ (LCIS) entirely confined to a large fibroadenoma without LCIS in the surrounding breast tissue.
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Pneumatosis cystoides intestinalis in an elderly patient, better to be safe than sorry: AbstractPneumatosis cystoides intestinalis is a rare pathology with nonspecific symptoms that can be easily misdiagnosed. Clinical awareness along with close surveillance is critical to effectively diagnose and treat this condition. Current treatment is based on conservative therapy including antibiotics and oxygen. Surgery is only recommended when complications are suspected. Here, we present the case of a 72-year-old...
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Obstructive Sleep Apnea due to Oromandibular Dystonia and Treated with Botulinum Toxin.: Related ArticlesObstructive Sleep Apnea due to Oromandibular Dystonia and Treated with Botulinum Toxin.J Clin Sleep Med. 2020 Apr 06;:Authors: Hsu N, Hsieh C, Thomas A, Chang MAbstract None: Abnormalities of the upper airway anatomy are an underrecognized cause of obstructive sleep apnea. We present a unique case of a 51-year-old man with episodic sleep-maintenance insomnia and oromandibular dystonia...
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Physical Activity is Associated With Reduced Prevalence of Self-Reported Obstructive Sleep Apnea in a Large, General Population Cohort Study.: Related ArticlesPhysical Activity is Associated With Reduced Prevalence of Self-Reported Obstructive Sleep Apnea in a Large, General Population Cohort Study.J Clin Sleep Med. 2020 Apr 06;:Authors: Hall KA, Singh M, Mukherjee S, Palmer LJAbstract STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is a common condition with significant symptoms and long-term...
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Polysomnographic characteristics of severe obstructive sleep apnea vary significantly between hypertensive and normotensive patients of both genders.: Related ArticlesPolysomnographic characteristics of severe obstructive sleep apnea vary significantly between hypertensive and normotensive patients of both genders.Sleep Breath. 2020 Apr 05;:Authors: Leppänen T, Kulkas A, Töyräs J, Myllymaa S, Gadoth N, Oksenberg AAbstract PURPOSE: Hypertension is a common finding in patients with obstructive...
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Is Sleep Quality Impaired and Is There Increased Risk of Obstructive Sleep Apnea Syndrome in Patients With Compensated Liver Cirrhosis?: Related ArticlesIs Sleep Quality Impaired and Is There Increased Risk of Obstructive Sleep Apnea Syndrome in Patients With Compensated Liver Cirrhosis?Gastroenterol Nurs. 2020 Mar/Apr;43(2):126-134Authors: Bueno CGR, Andrechuk CRS, Ceolim MFAbstract As liver cirrhosis worsens, sleep pattern impairment and related complaints increase. The objective of this...
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CREB1-induced lncRNA LEF1-AS1 contributes to colorectal cancer progression via the miR-489/DIAPH1 axis.: Related ArticlesCREB1-induced lncRNA LEF1-AS1 contributes to colorectal cancer progression via the miR-489/DIAPH1 axis.Biochem Biophys Res Commun. 2020 Apr 02;:Authors: Cheng Y, Wu J, Qin B, Zou BC, Wang YH, Li YAbstract Long non-coding RNAs (lncRNAs) have been identified as new regulatory factors in tumor progression. Lymphoid enhancer-binding factor 1 antisense RNA 1 (LEF1-AS1) was a...
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Cannabis and Radiation Therapy: A Scoping Review of Human Clinical Trials.: Related ArticlesCannabis and Radiation Therapy: A Scoping Review of Human Clinical Trials.J Med Imaging Radiat Sci. 2020 Apr 02;:Authors: Rosewall T, Feuz C, Bayley AAbstract INTRODUCTION: It is estimated that at least 20% of Canadian patients with cancer use cannabis to alleviate symptoms of their disease and/or cope with the side effects of their treatment. Most patients want to learn more about cannabis from their...
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Humour and laughing in patients with prolonged incurable cancer: an ethnographic study in a comprehensive cancer centre.: Related ArticlesHumour and laughing in patients with prolonged incurable cancer: an ethnographic study in a comprehensive cancer centre.Qual Life Res. 2020 Apr 06;:Authors: Buiting HM, de Bree R, Brom L, Mack JW, van den Brekel MWMAbstract PURPOSE: Most people are familiar with the expression 'laughter is the best medicine'. By enhancing cognitive flexibility and strengthening...
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Establishment of Immortalized Laryngeal Epithelial Cells Transfected with Bmi1.: Related ArticlesEstablishment of Immortalized Laryngeal Epithelial Cells Transfected with Bmi1.Cell Transplant. 2020 Jan-Dec;29:963689720908198Authors: Tan JJ, Wang L, Mo TT, Dai YF, Lu J, Liu X, Chen HH, Tian WD, Li XPAbstract Primary laryngeal epithelial cells are essential to exploring the mechanisms of laryngeal and voice disorders; however, they are difficult to study and apply because of their limited life...
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Emerging therapeutic targets for nasopharyngeal carcinoma: opportunities and challenges.: Related ArticlesEmerging therapeutic targets for nasopharyngeal carcinoma: opportunities and challenges.Expert Opin Ther Targets. 2020 Apr 04;:Authors: Baloche V, Ferrand FR, Makowska A, Even C, Kontny U, Busson PAbstract Introduction: Nasopharyngeal carcinoma (NPC) is a major public health problem in several countries, especially those in Southeast Asia and North Africa. In its typical poorly differentiated...
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Association of periodic limb movements during sleep and tinnitus in humans.: Related ArticlesAssociation of periodic limb movements during sleep and tinnitus in humans.Sci Rep. 2020 Apr 06;10(1):5972Authors: Hwang SW, Chu YC, Hwang SR, Hwang JHAbstract Both of periodic limb movements during sleep (PLMS) and tinnitus were related with dopaminergic system dysfunction. However, it was still unclear whether PLMS, one kind of sleep disturbances, was associated with chronic tinnitus or not. Thus,...
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Association of periodic limb movements during sleep and tinnitus in humans.: Related ArticlesAssociation of periodic limb movements during sleep and tinnitus in humans.Sci Rep. 2020 Apr 06;10(1):5972Authors: Hwang SW, Chu YC, Hwang SR, Hwang JHAbstract Both of periodic limb movements during sleep (PLMS) and tinnitus were related with dopaminergic system dysfunction. However, it was still unclear whether PLMS, one kind of sleep disturbances, was associated with chronic tinnitus or not. Thus,...
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Developmental Regulation of Basket Interneuron Synapses and Behavior through NCAM in Mouse Prefrontal Cortex.: Related ArticlesDevelopmental Regulation of Basket Interneuron Synapses and Behavior through NCAM in Mouse Prefrontal Cortex.Cereb Cortex. 2020 Apr 06;:Authors: Sullivan CS, Mohan V, Manis PB, Moy SS, Truong Y, Duncan BW, Maness PFAbstract Parvalbumin (PV)-expressing basket interneurons in the prefrontal cortex (PFC) regulate pyramidal cell firing, synchrony, and network oscillations....
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Rural-Urban Disparities in Otolaryngology: The State of Illinois.: Related ArticlesRural-Urban Disparities in Otolaryngology: The State of Illinois.Laryngoscope. 2020 Apr 06;:Authors: Urban MJ, Wojcik C, Eggerstedt M, Jagasia AJAbstract OBJECTIVES/HYPOTHESIS: To highlight rural-urban disparities in otolaryngology, and to quantify the disparities in access to otolaryngology specialist care across Illinois. Several studies across disciplines have shown increased prevalence and severity of disease...
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Development and validation of an algorithm of diagnostic and procedural codes for the identification of children hospitalized with a tracheostomy in Ontario, Canada.: Related ArticlesDevelopment and validation of an algorithm of diagnostic and procedural codes for the identification of children hospitalized with a tracheostomy in Ontario, Canada.Pediatr Pulmonol. 2020 Apr 06;:Authors: McKelvie B, Pianosi K, Chan J, Tsampalieros A, Benchimol EI, Macdonald KI, Strychowshy J, Vaccani JP, McNally JDAbstract...
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Quantifying the impact of optical surface guidance in the treatment of cancers of the head and neck.
Quantifying the impact of optical surface guidance in the treatment of cancers of the head and neck.: Related ArticlesQuantifying the impact of optical surface guidance in the treatment of cancers of the head and neck.J Appl Clin Med Phys. 2020 Apr 06;:Authors: Wei W, Ioannides PJ, Sehgal V, Daroui PAbstract Surface guided radiation therapy (SGRT) is increasingly being adopted for use in radiation treatment delivery for Head and Neck (H&N) cancer patients. This study investigated the...
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Effect of monoclonal antibodies on olfactory dysfunction caused by chronic rhinosinusitis with nasal polyps: a systematic review and meta-analysis.: Related ArticlesEffect of monoclonal antibodies on olfactory dysfunction caused by chronic rhinosinusitis with nasal polyps: a systematic review and meta-analysis.Int Forum Allergy Rhinol. 2020 Apr 06;:Authors: Tsetsos N, Markou K, Konstantinidis IAbstract BACKGROUND: Olfactory dysfunction is a common complaint in patients suffering from chronic...
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In vitro safety evaluation of a povidone-iodine solution applied to human nasal epithelial cells.: Related ArticlesIn vitro safety evaluation of a povidone-iodine solution applied to human nasal epithelial cells.Int Forum Allergy Rhinol. 2020 Apr 06;:Authors: Ramezanpour M, Smith JLP, Psaltis AJ, Wormald PJ, Vreugde SAbstract BACKGROUND: Nasal topical treatments can provide an effective method of disease control for patients suffering from chronic rhinosinusitis (CRS). However, some frequently...
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Nasal Bone Fractures: Analysis of 1193 Cases with an Emphasis on Coincident Adjacent Fractures.: Related ArticlesNasal Bone Fractures: Analysis of 1193 Cases with an Emphasis on Coincident Adjacent Fractures.Facial Plast Surg Aesthet Med. 2020 Apr 06;:Authors: Li L, Zang H, Han D, Yang B, Desai SC, London NRAbstract Importance: The nasal bone is one of the most commonly fractured bones of the midface. However, the frequency of coincident fractures of adjacent bones such as the frontal process...
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Long-Term Stability of Vascularized Adipofascial Flaps in Facial Reconstruction.: Related ArticlesLong-Term Stability of Vascularized Adipofascial Flaps in Facial Reconstruction.Facial Plast Surg Aesthet Med. 2020 Apr 06;:Authors: Strohl MP, Junn JC, House AE, Heaton CM, Seth R, Park AM, Knott PDAbstract Objectives: To determine the quantitative volume change over time of vascularized adipofascial anterolateral thigh (AFALT) free flaps in facial reconstruction, and to evaluate patient factors...
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Combining immunotherapy and radiotherapy in head and neck squamous cell cancers: which perspectives?
Combining immunotherapy and radiotherapy in head and neck squamous cell cancers: which perspectives?: Related ArticlesCombining immunotherapy and radiotherapy in head and neck squamous cell cancers: which perspectives?Curr Opin Oncol. 2020 May;32(3):196-202Authors: Biau J, Bourhis JAbstract PURPOSE OF REVIEW: The role of the immune system is important in both initiation and development of head and neck cancers. Various immune checkpoints have been discovered that can be exploited by cancer...
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Periorbital Myofibroma in a child: A Case Report and Review of the Literature.: Related ArticlesPeriorbital Myofibroma in a child: A Case Report and Review of the Literature.Ophthalmic Plast Reconstr Surg. 2020 Apr 03;:Authors: Sim B, Gal A, Tumuluri KAbstract Infantile myofibroma is a rare benign tumor usually diagnosed before the age of 2 and found in the head and neck but much more rarely in the orbital region. There have only been 7 cases of periorbital myofibromas reported in children...
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Trends in the incidence and DALYs of bipolar disorder at global, regional, and national levels: Results from the global burden of Disease Study 2017.: Related ArticlesTrends in the incidence and DALYs of bipolar disorder at global, regional, and national levels: Results from the global burden of Disease Study 2017.J Psychiatr Res. 2020 Mar 27;125:96-105Authors: He H, Hu C, Ren Z, Bai L, Gao F, Lyu JAbstract The objective of this study is to assess the global, regional, and national burden...
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Loss of inner hair cell ribbon synapses and auditory nerve fiber regression in Cldn14 knockout mice.
Loss of inner hair cell ribbon synapses and auditory nerve fiber regression in Cldn14 knockout mice.: Related ArticlesLoss of inner hair cell ribbon synapses and auditory nerve fiber regression in Cldn14 knockout mice.Hear Res. 2020 Mar 16;391:107950Authors: Claußen M, Schulze J, Nothwang HGAbstract Proper functioning of the auditory nerve is of critical importance for auditory rehabilitation by cochlear implants. Here we used the Cldn14-/- mouse to study in detail the effects of Claudin...
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Chemotherapy after immune checkpoint blockade in patients with recurrent, metastatic squamous cell carcinoma of the head and neck.: Related ArticlesChemotherapy after immune checkpoint blockade in patients with recurrent, metastatic squamous cell carcinoma of the head and neck.Oral Oncol. 2020 Apr 03;105:104676Authors: Kacew AJ, Harris EJ, Lorch JH, Schoenfeld JD, Margalit DN, Kass JI, Tishler RB, Haddad RI, Hanna GJAbstract OBJECTIVES: Given that immune checkpoint inhibitors (ICIs) are now...
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Loss of S6K1 But Not S6K2 in the Tumor Microenvironment Suppresses Tumor Growth by Attenuating Tumor Angiogenesis.: Related ArticlesLoss of S6K1 But Not S6K2 in the Tumor Microenvironment Suppresses Tumor Growth by Attenuating Tumor Angiogenesis.Transl Oncol. 2020 Apr 03;13(4):100767Authors: Lee S, Roh HS, Song SS, Shin J, Lee J, Bhang DH, Kim BG, Um SH, Jeong HS, Baek KHAbstract Two isoforms of the 70-kDa ribosomal protein S6 kinase, S6K1 and S6K2, have been identified and are considered...
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Rab25-Mediated EGFR Recycling Causes Tumor Acquired Radioresistance.: Related ArticlesRab25-Mediated EGFR Recycling Causes Tumor Acquired Radioresistance.iScience. 2020 Mar 20;23(4):100997Authors: Zhang L, Xie B, Qiu Y, Jing D, Zhang J, Duan Y, Li Z, Fan M, He J, Qiu Y, Tan R, Li JJ, Sun LQAbstract Tumor acquired radioresistance remains as the major limit in cancer radiotherapy (RT). Rab25, a receptor recycling protein, has been reported to be enhanced in tumors with aggressive phenotype...
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Concomitant Isolation of Primary Astrocytes and Microglia for Protozoa Parasite Infection.: Related ArticlesConcomitant Isolation of Primary Astrocytes and Microglia for Protozoa Parasite Infection.J Vis Exp. 2020 Mar 18;(157):Authors: Pacheco AOL, Amaral MP, de Farias IS, Bottino LZMF, Bortoluci KRAbstract Astrocytes and microglia are the most abundant glial cells. They are responsible for physiological support and homeostasis maintenance in the central nervous system (CNS). The increasing...
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Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications.: Related ArticlesSynthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications.J Vis Exp. 2020 Mar 22;(157):Authors: Pramanik G, Keprova A, Valenta J, Bocan V, Kvaková K, Libusova L, Cigler PAbstract Over the past decade, fluorescent gold nanoclusters (AuNCs) have witnessed growing popularity in biological applications and enormous efforts have been devoted to their development. In this...
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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression.: Related ArticlesMultidimensional Coculture System to Model Lung Squamous Carcinoma Progression.J Vis Exp. 2020 Mar 17;(157):Authors: Chen S, Giannakou A, Golas J, Geles KGAbstract Tumor-stroma interactions play a critical role in the development of lung squamous carcinoma (LUSC). However, understanding how these dynamic interactions contribute to tissue architectural changes observed during tumorigenesis remains...
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Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation.: Related ArticlesHuman Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation.J Vis Exp. 2020 Mar 21;(157):Authors: Fan Y, Tonelli F, Padmanabhan S, Baptista MAS, Riley L, Smith D, Marras C, Howden A, Alessi DR, Sammler EAbstract The leucine rich repeat kinase 2...
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model.: Related ArticlesStudying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model.J Vis Exp. 2020 Mar 20;(157):Authors: Cheng RYS, Patel NL, Back T, Basudhar D, Somasundaram V, Kalen JD, Wink DA, Ridnour LAAbstract Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited therapeutic options. When compared to patients with less aggressive breast tumors, the 5-year survival...
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Detection of Protein Ubiquitination Sites by Peptide Enrichment and Mass Spectrometry.: Related ArticlesDetection of Protein Ubiquitination Sites by Peptide Enrichment and Mass Spectrometry.J Vis Exp. 2020 Mar 23;(157):Authors: Bezstarosti K, van der Wal L, Demmers JAAAbstract The posttranslational modification of proteins by the small protein ubiquitin is involved in many cellular events. After tryptic digestion of ubiquitinated proteins, peptides with a diglycine remnant conjugated to the...
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Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease.: Related ArticlesBone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease.J Vis Exp. 2020 Mar 17;(157):Authors: Nguyen HD, Huong PT, Hossack K, Gurshaney S, Ezhakunnel K, Huynh TH, Alvarez AM, Le NT, Luu HNAbstract Allogeneic bone marrow transplantation (BMT) is an effective therapy for hematological malignancies due to the graft-versus-leukemia...
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Slicing and Culturing Pig Hearts under Physiological Conditions.: Related ArticlesSlicing and Culturing Pig Hearts under Physiological Conditions.J Vis Exp. 2020 Mar 20;(157):Authors: Ou Q, Abouleisa RRE, Tang XL, Juhardeen HR, Meki MH, Miller JM, Giridharan G, El-Baz A, Bolli R, Mohamed TMAAbstract Many novel drugs fail in clinical studies due to cardiotoxic side effects as the currently available in vitro assays and in vivo animal models poorly predict human cardiac liabilities, posing...
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Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype.: Related ArticlesTransduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype.J Vis Exp. 2020 Mar 18;(157):Authors: Pampusch MS, Skinner PJAbstract Emerging immunotherapies to treat infectious diseases and cancers often involve transduction of cellular populations with genes encoding disease-targeting proteins. For example, chimeric antigen receptor...
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A Modified Lean and Release Technique to Emphasize Response Inhibition and Action Selection in Reactive Balance.: Related ArticlesA Modified Lean and Release Technique to Emphasize Response Inhibition and Action Selection in Reactive Balance.J Vis Exp. 2020 Mar 19;(157):Authors: Bolton DAE, Mansour MAbstract Assessment of reactive balance traditionally imposes some type of perturbation to upright stance or gait followed by measurement of the resultant corrective behavior. These measures include...
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Preparation of SNS Cobalt(II) Pincer Model Complexes of Liver Alcohol Dehydrogenase.: Related ArticlesPreparation of SNS Cobalt(II) Pincer Model Complexes of Liver Alcohol Dehydrogenase.J Vis Exp. 2020 Mar 19;(157):Authors: Miecznikowski JR, Jasinski JP, Kaur M, Bonitatibus SC, Almanza EM, Kharbouch RM, Zygmont SE, Landy KRAbstract Chemical model complexes are prepared to represent the active site of an enzyme. In this protocol, a family of tridentate pincer ligand precursors (each possessing...
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Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging.: Related ArticlesCapturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging.J Vis Exp. 2020 Mar 17;(157):Authors: Salamon RJ, Zhang Z, Mahmoud AIAbstract Cardiovascular disease outranks all other causes of death and is responsible for a staggering 31% of mortalities worldwide. This disease manifests in cardiac injury, primarily...
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Visualizing the Developing Brain in Living Zebrafish using Brainbow and Time-lapse Confocal Imaging.
Visualizing the Developing Brain in Living Zebrafish using Brainbow and Time-lapse Confocal Imaging.: Related ArticlesVisualizing the Developing Brain in Living Zebrafish using Brainbow and Time-lapse Confocal Imaging.J Vis Exp. 2020 Mar 23;(157):Authors: Cook ZT, Brockway NL, Weissman TAAbstract Development of the vertebrate nervous system requires a precise coordination of complex cellular behaviors and interactions. The use of high resolution in vivo imaging techniques can provide a clear...
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Seizure Following Percutaneous Endoscopic Surgery-Incidence, risk factors, prevention and management.: Related ArticlesSeizure Following Percutaneous Endoscopic Surgery-Incidence, risk factors, prevention and management.World Neurosurg. 2020 Apr 03;:Authors: Lin CY, Chang CC, Tseng C, Chen YJ, Tsai CH, Lo YS, Hsiao PH, Tsou HK, Lin CS, Chen HTAbstract BACKGROUND: Percutaneous endoscopic surgery is a popular surgery to treat lumbar spinal disorders. However, seizure following percutaneous...
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Seizure Following Percutaneous Endoscopic Surgery-Incidence, risk factors, prevention and management.: Related ArticlesSeizure Following Percutaneous Endoscopic Surgery-Incidence, risk factors, prevention and management.World Neurosurg. 2020 Apr 03;:Authors: Lin CY, Chang CC, Tseng C, Chen YJ, Tsai CH, Lo YS, Hsiao PH, Tsou HK, Lin CS, Chen HTAbstract BACKGROUND: Percutaneous endoscopic surgery is a popular surgery to treat lumbar spinal disorders. However, seizure following percutaneous...
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Risk factors for early mortality in patients with primary central nervous system lymphoma: A large-cohort retrospective study.: Related ArticlesRisk factors for early mortality in patients with primary central nervous system lymphoma: A large-cohort retrospective study.World Neurosurg. 2020 Apr 03;:Authors: Zhou X, Niu X, Li J, Zhang S, Yang W, Yang Y, Mao Q, Liu YAbstract OBJECTIVE: This study aimed to assess early mortality (within 1 and 3 months) in patients with primary central nervous...
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National Trends and Factors Predicting Outcomes Following Laser Interstitial thermal therapy (LITT) for Brain Lesions: A Nationwide Inpatient Sample Analysis.: Related ArticlesNational Trends and Factors Predicting Outcomes Following Laser Interstitial thermal therapy (LITT) for Brain Lesions: A Nationwide Inpatient Sample Analysis.World Neurosurg. 2020 Apr 03;:Authors: Sharma M, Ugiliweneza B, Wang D, Boakye M, Andaluz N, Neimat J, Mohammadi A, Barnett GH, Williams BJAbstract INTRODUCTION:...
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Enlarging Perivascular Spaces Following Radiation Therapy in the Brain: A Report of Two Cases and Literature Review.: Related ArticlesEnlarging Perivascular Spaces Following Radiation Therapy in the Brain: A Report of Two Cases and Literature Review.World Neurosurg. 2020 Apr 03;:Authors: Mark IT, Carr CM, Ruff MW, Flanagan EP, Johnson DRAbstract BACKGROUND: Virchow-Robin or enlarged perivascular spaces (PVS) are benign pial-lined spaces that surround penetrating arteries and arterioles through...
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Anatomical study of the bifurcation of the obturator nerve: Application to more precise surgical/procedural localization.: Related ArticlesAnatomical study of the bifurcation of the obturator nerve: Application to more precise surgical/procedural localization.View allThe obturator nerve (latin: nervus obturatorius) is mixed nerve that originates from the lumbar plexus and innervates the muscles and skin in the medial region of the thigh. The obturator nerve arises from the ventral rami of the second,...
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Occipital artery to middle cerebral artery bypass using the descending branch of the lateral circumflex femoral artery as an interposition graft for blood flow augmentation in progressive Moyamoya disease.: Related ArticlesOccipital artery to middle cerebral artery bypass using the descending branch of the lateral circumflex femoral artery as an interposition graft for blood flow augmentation in progressive Moyamoya disease.World Neurosurg. 2020 Apr 03;:Authors: Srinivasan VM, Kan P, Huang AT, Burkhardt...
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Incidence of Subsidence of 7 intervertebral Devices in Anterior Cervical Discectomy and Fusion: A Network Meta-analysis.: Related ArticlesIncidence of Subsidence of 7 intervertebral Devices in Anterior Cervical Discectomy and Fusion: A Network Meta-analysis.World Neurosurg. 2020 Apr 03;:Authors: Xu J, He Y, Wang B, Lv GH, Li Y, Dai YL, Jiang B, Zheng ZAbstract INTRODUCTION: Subsidence is an incapacitating complication in Anterior cervical discectomy and fusion (ACDF). However, the debate...
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Is full-endoscopic lumbar discectomy less invasive than conventional surgery? A randomized MRI study.: Related ArticlesIs full-endoscopic lumbar discectomy less invasive than conventional surgery? A randomized MRI study.World Neurosurg. 2020 Apr 03;:Authors: Tacconi L, Signorelli F, Giordan EAbstract BACKGROUND: In this randomized prospective study, we compared surgical invasiveness through a quantitative volumetric analysis of postoperative paravertebral muscle signal intensity changes between...
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Clinical Outcomes in Patients with Renal Cell Carcinoma Metastases to the Choroid Plexus.: Related ArticlesClinical Outcomes in Patients with Renal Cell Carcinoma Metastases to the Choroid Plexus.World Neurosurg. 2020 Apr 03;:Authors: Crisman CM, Patel AR, Winston G, Brennan CW, Tabar V, Moss NSAbstract OBJECTIVE: Intraventricular metastatic brain tumors account for a small but challenging fraction of metastatic brain tumors (0.9-4.5%). Metastases from renal cell carcinoma (RCC) account for...
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Comparative Radiographic Factors Predicting Functional Outcome after Decompressive Craniectomy in Severe Traumatic Brain Injury.: Related ArticlesComparative Radiographic Factors Predicting Functional Outcome after Decompressive Craniectomy in Severe Traumatic Brain Injury.World Neurosurg. 2020 Apr 03;:Authors: Fatima N, Mohamed ME, De Leon A, El Beltagi A, Shuaib A, Saqqur MAbstract OBJECTIVES: Decompressive Craniectomy (DC) is a last-tier therapy in the treatment of raised intracranial...
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Partially Cystic Lumbar Schwannoma with Atypical Histopathological Features.: Related ArticlesPartially Cystic Lumbar Schwannoma with Atypical Histopathological Features.World Neurosurg. 2020 Apr 03;:Authors: Lak AM, Abunimer AM, Segar D, Zaidi HAAbstract BACKGROUND: Spinal schwannomas are benign nerve sheath neoplasms which constitute about 30% of extramedullary spinal cord tumors. They are usually small, well-encapsulated tumors with low mitotic activity, and concurrently carry low risk...
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Blocking VEGF by Bevacizumab Attenuates VEGF-Induced Vasospasm After Experimental Subarachnoid Hemorrhage in Rabbits.: Related ArticlesBlocking VEGF by Bevacizumab Attenuates VEGF-Induced Vasospasm After Experimental Subarachnoid Hemorrhage in Rabbits.World Neurosurg. 2020 Apr 03;:Authors: Akturk UD, Tuncer C, Bozkurt H, Sahin OS, Bulut H, Arikok A, Dinc C, Gurer B, Turkoglu EAbstract OBJECTIVE: Vasospasm after subarachnoid hemorrhage (SAH) plays a vital role in the development of delayed...
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Professional Profiles, Technical Preferences, Surgical Opinions, and Management of Clinical Scenarios from a Panel of 63 International Experts in the field of Chiari I Malformation.: Related ArticlesProfessional Profiles, Technical Preferences, Surgical Opinions, and Management of Clinical Scenarios from a Panel of 63 International Experts in the field of Chiari I Malformation.World Neurosurg. 2020 Apr 03;:Authors: Bolognese PA, Brodbelt AAbstract Chiari I Malformation (CMI) and the topics...
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10 segments intramedullary ependymoma and whole spinal syringomyelia.: Related Articles10 segments intramedullary ependymoma and whole spinal syringomyelia.World Neurosurg. 2020 Apr 03;:Authors: Shen C, Li T, Shi Z, Yang BAbstract BACKGROUND: 10-segments intramedullary tumors are rare lesions in adults. CASE DESCRIPTION: In this report, we describe the case of one 30-year-old woman who presented with a 2-year history of right lower limb numbness. Spinal magnetic resonance imaging of...
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Aberrant Abducent Nerve during Microvascular Decompression for Trigeminal Neuralgia.: Related ArticlesAberrant Abducent Nerve during Microvascular Decompression for Trigeminal Neuralgia.World Neurosurg. 2020 Apr 03;:Authors: Borg A, Zrinzo LAbstract BACKGROUND: Microvascular decompression (MVD) is a commonly performed procedure to treat trigeminal neuralgia and hemifacial spasm. Knowledge of the variable anatomy of the cerebellopontine angle is crucial to avoid injury to cranial nerves. ...
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Gamma Knife Radiosurgery in Patients with Crooke's Cell Adenoma.: Related ArticlesGamma Knife Radiosurgery in Patients with Crooke's Cell Adenoma.World Neurosurg. 2020 Apr 03;:Authors: Snyder MH, Shabo L, Lopes MB, Xu Z, Schlesinger D, Sheehan JPAbstract BACKGROUND: Crooke cell adenoma (CCA), is a very rare subtype of pituitary neoplasm which is known to be clinically aggressive. They can secrete adrenocorticotropic hormone, or may be endocrinologically silent. We aim to evaluate the effect...
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CIC-rearranged undifferentiated round cell sarcoma metastatic to the brain treated with surgery and stereotactic radiosurgery: Case report.: Related ArticlesCIC-rearranged undifferentiated round cell sarcoma metastatic to the brain treated with surgery and stereotactic radiosurgery: Case report.World Neurosurg. 2020 Apr 03;:Authors: Helal A, Graffeo CS, Perry A, Cheville JC, Link MJ, Pollock BEAbstract BACKGROUND: Ewing-like sarcoma with CIC-rearrangement are a unique class of undifferentiated...
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Brain Metastases of Wilms Tumor in Adult - Rare Case Report.: Related ArticlesBrain Metastases of Wilms Tumor in Adult - Rare Case Report.World Neurosurg. 2020 Apr 03;:Authors: Caramanti RL, Aprígio RM, de Moraes DF, Rocha CEDA, Meguins LC, Goes MJ, da Costa MD, Chaddad FAbstract BACKGROUND: Wilms tumor is a rare renal tumor in adults. In our knowledge a small number of cases of brain metastasis were reported in literature. The authors report a case of 29-year-old female with headache and...
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Posterior-only surgical correction with heavy halo-femoral traction for the treatment of severe and rigid congenital scoliosis associated with tethered spinal cord and Type II split cord malformation.: Related ArticlesPosterior-only surgical correction with heavy halo-femoral traction for the treatment of severe and rigid congenital scoliosis associated with tethered spinal cord and Type II split cord malformation.World Neurosurg. 2020 Apr 03;:Authors: Zhang HQ, Deng A, Liu SH, Wang YX, Alonge EAbstract...
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A rare case of spinal dural arteriovenous fistula with radiculopathy, without myelopathy or spinal edema on magnetic resonance imaging.: Related ArticlesA rare case of spinal dural arteriovenous fistula with radiculopathy, without myelopathy or spinal edema on magnetic resonance imaging.World Neurosurg. 2020 Apr 03;:Authors: Oki S, Osanai T, Tokairin K, Takamiya S, Yamazaki K, Imai T, Seki TAbstract BACKGROUND: Spinal dural arteriovenous fistulas (SDAVFs) are the most common type of spinal...
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Sylvian and Insular Exposure in the Extended Minipterional Approach: Landmarks, benefits, and quantitative analysis based on a cadaveric study.: Related ArticlesSylvian and Insular Exposure in the Extended Minipterional Approach: Landmarks, benefits, and quantitative analysis based on a cadaveric study.World Neurosurg. 2020 Apr 03;:Authors: Martinez-Perez R, Hardesty DA, Li R, Carrau RL, Prevedello DMAbstract OBJECTIVE: The Minipterional approach (MPTa) has been widely accepted as a minimally...
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J Thorac Dis. 2016 Dec; 8(12): 3762–3773.doi: 10.21037/jtd.2016.12.88PMCID: PMC5227239PMID: 28149575Veno-venous extracorporeal membrane oxygenation: cannulation techniquesCarlo Banfi,1,2,3 Matteo Pozzi,4 Nils Siegenthaler,2,3,5 Marie-Eve Brunner,5 Didier Tassaux,5 Jean-Francois Obadia,4 Karim Bendjelid,2,3,5 and Raphaël Giraud2,3,5Author information Article notes Copyright and License information Disclaimer1Division of Cardiovascular Surgery, Geneva University Hospitals, Geneva, Switzerland;2Faculty...
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Veno-Venous Extracorporeal Membrane Oxygenation for Severe Pneumocystis jirovecii Pneumonia in an Immunocompromised Patient without HIV Infection.: Related ArticlesVeno-Venous Extracorporeal Membrane Oxygenation for Severe Pneumocystis jirovecii Pneumonia in an Immunocompromised Patient without HIV Infection.Tohoku J Exp Med. 2020;250(4):215-221Authors: Nureki SI, Usagawa Y, Watanabe E, Takenaka R, Shigemitsu O, Abe T, Yasuda N, Goto K, Kitano T, Kadota JIAbstract Pneumocystis jirovecii pneumonia...
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Functional evaluation following deltoid muscle resection in patients with soft tissue sarcoma.: Related ArticlesFunctional evaluation following deltoid muscle resection in patients with soft tissue sarcoma.Jpn J Clin Oncol. 2020 Apr 06;:Authors: Hamada S, Nishida Y, Takanari K, Ota T, Urakawa H, Ikuta K, Sakai T, Tsukushi S, Kamei Y, Ishiguro NAbstract BACKGROUND: The present study aimed to determine functional outcomes in patients undergoing deltoid muscle resection for soft tissue sarcoma....
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Role of physical exercise type in olfactory deterioration in ageing.: Related ArticlesRole of physical exercise type in olfactory deterioration in ageing.Rhinology. 2020 Apr 01;58(2):145-150Authors: Zhang C, Li D, Wang XAbstract BACKGROUND: Although ageing and neurodegenerative diseases, including Alzheimer disease, have been associated with olfaction impairment, studies exploring how to ameliorate this impairment are limited. The aim of the present study was to determine the effect of various...
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Nasal fluid cytology and cytokine profiles of eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps.: Related ArticlesNasal fluid cytology and cytokine profiles of eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps.Rhinology. 2020 Apr 06;:Authors: Zhu Z, Wang W, Zhang X, Wang X, Zha Y, Chen Y, Zhou L, Lv WAbstract BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease with different clinical characteristics and...
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HPV may not play a role in all lacrimal transitional cell papilloma.: Related ArticlesHPV may not play a role in all lacrimal transitional cell papilloma.Rhinology. 2020 Apr 06;:Authors: Jones H, Gane S, Rimmer J, Cuschieri K, Lund VJAbstract BACKGROUND: Tumours of the lacrimal duct apparatus (LDA) are rare and heterogenous but knowledge of their aetiology is important for the rhinologist. A link between transitional cell papilloma/carcinoma (TCP/TCC) and human papilloma virus (HPV) has been...
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A Sleep Apnea Prediction Model Developed for African Americans, the Jackson Heart Sleep Study.: Related ArticlesA Sleep Apnea Prediction Model Developed for African Americans, the Jackson Heart Sleep Study.J Clin Sleep Med. 2020 Apr 06;:Authors: Johnson DA, Sofer T, Guo N, Wilson J, Redline SAbstract STUDY OBJECTIVES: African Americans have a high prevalence of severe sleep apnea which is often undiagnosed. We developed a prediction model for sleep apnea and compared the predictive values...
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Low quality of reports on blood pressure in patients adrenalectomized for unilateral primary aldosteronism.: Related ArticlesLow quality of reports on blood pressure in patients adrenalectomized for unilateral primary aldosteronism.J Clin Endocrinol Metab. 2020 Mar 31;:Authors: Lenders JWM, Deinum J, Passauer J, Januszewicz A, Chan OYA, Prejbisz AAbstract CONTEXT: Adrenalectomy is the preferred treatment for unilateral primary aldosteronism but the results of long-term control of blood pressure...
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Novel roles of chloroquine and hydroxychloroquine in Graves' orbitopathy therapy by targeting orbital fibroblasts.: Related ArticlesNovel roles of chloroquine and hydroxychloroquine in Graves' orbitopathy therapy by targeting orbital fibroblasts.J Clin Endocrinol Metab. 2020 Mar 31;:Authors: Guo Y, Li H, Chen X, Yang H, Guan H, He X, Chen Y, Pokharel S, Xiao H, Li YAbstract CONTEXT: Graves' orbitopathy (GO) causes infiltrative exophthalmos by inducing excessive proliferation, adipogenesis...
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Cardiac myxoma caused by fumarate hydratase gene deletion in patient with cortisol-secreting adrenocortical adenoma.: Related ArticlesCardiac myxoma caused by fumarate hydratase gene deletion in patient with cortisol-secreting adrenocortical adenoma.J Clin Endocrinol Metab. 2020 Apr 06;:Authors: Suda K, Fukuoka H, Yamazaki Y, Shigemura K, Mukai M, Odake Y, Matsumoto R, Bando H, Takahashi M, Iguchi G, Fujisawa M, Oka M, Ono K, Chihara K, Sasano H, Ogawa W, Takahashi YAbstract CONTEXT: Germline...
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Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Failure, and Organomegaly (TAFRO) Syndrome with Bilateral Adrenal Hemorrhage in Two Caucasian Patients.: Related ArticlesThrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Failure, and Organomegaly (TAFRO) Syndrome with Bilateral Adrenal Hemorrhage in Two Caucasian Patients.Am J Case Rep. 2020 Apr 06;21:e919536Authors: Ducoux G, Guerber A, Durel CA, Asli B, Fadlallah J, Hot AAbstract BACKGROUND Thrombocytopenia, anasarca,...
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Effect of Pegylated Interferon and Mitomycin C on Ocular Surface Squamous Neoplasia in Xeroderma Pigmentosum: A Case Series.: Related ArticlesEffect of Pegylated Interferon and Mitomycin C on Ocular Surface Squamous Neoplasia in Xeroderma Pigmentosum: A Case Series.Am J Case Rep. 2020 Apr 06;21:e921301Authors: Dirar QS, Musalem HM, Al-Hazzaa SAF, Al Zoba AA, Almalki AAAbstract BACKGROUND Xeroderma pigmentosum (XP) is an autosomal recessive disease caused by mutations in DNA repair genes....
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[The sensitivity and specificity of the Mini-Audio-Test (MAT) for different levels of hearing loss].
[The sensitivity and specificity of the Mini-Audio-Test (MAT) for different levels of hearing loss].: Related Articles[The sensitivity and specificity of the Mini-Audio-Test (MAT) for different levels of hearing loss].Laryngorhinootologie. 2020 Apr 06;:Authors: Löhler J, Lehmann M, Segler V, Volkenstein S, Battmer RD, Ernst A, Gräbner F, Schlattmann P, Schönweiler R, Wollenberg B, Dazert SAbstract BACKGROUND: An untreated hearing impairment could have a severe influence on the morbidity....
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Drp1 expression levels correlate with clinical stage in extramammary Paget's disease.: Related ArticlesDrp1 expression levels correlate with clinical stage in extramammary Paget's disease.J Eur Acad Dermatol Venereol. 2020 Apr 06;:Authors: Kitamura S, Yanagi T, Maeda T, Shimizu HAbstract Extramammary Paget's disease (EMPD) is a rare malignant neoplasm that often presents in areas that abound in apocrine sweat glands1 . Dynamin related protein 1 (Drp1) is a GTPase that regulates mitochondrial...
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Fishing for neuroendocrine tumors.: Related ArticlesFishing for neuroendocrine tumors.Endocr Relat Cancer. 2020 Apr 01;:Authors: Gaudenzi G, Carra S, Dicitore A, Cantone MC, Persani L, Vitale GAbstract Neuroendocrine tumors (NETs) are a class of rare and heterogeneous neoplasms that originate from the neuroendocrine system. In several cases these neoplasms can release bioactive hormones leading to characteristic clinical syndromes and hormonal dysregulations with detrimental impact on the...
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Management of the pancreatic transection plane after left (distal) pancreatectomy: Expert consensus guidelines by the International Study Group of Pancreatic Surgery (ISGPS).: Related ArticlesManagement of the pancreatic transection plane after left (distal) pancreatectomy: Expert consensus guidelines by the International Study Group of Pancreatic Surgery (ISGPS).Surgery. 2020 Apr 02;:Authors: Miao Y, Lu Z, Yeo CJ, Vollmer CM, Fernandez-Del Castillo C, Ghaneh P, Halloran CM, Kleeff J, de Rooij T,...
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Analysis of patent innovation in the field of brachytherapy.: Related ArticlesAnalysis of patent innovation in the field of brachytherapy.Brachytherapy. 2020 Apr 02;:Authors: Miljanic M, Prabhu AV, Patel M, Lewis GD, Kim TAbstract PURPOSE: To characterize inventions and assess trends in brachytherapy innovation based on brachytherapy-related patents awarded across the past 2 decades and provide insights that will help inform future research and entrepreneurship in the field. METHODS:...
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A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors.: Related ArticlesA Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors.Am J Clin Oncol. 2020 Apr 02;:Authors: McDonald PC, Chia S, Bedard PL, Chu Q, Lyle M, Tang L, Singh M, Zhang Z, Supuran CT, Renouf DJ, Dedhar SAbstract OBJECTIVES: SLC-0111 is an ureido-substituted benzenesulfonamide small molecule inhibitor of carbonic...
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Zebrafish patient avatars in cancer biology and precision cancer therapy.: Related ArticlesZebrafish patient avatars in cancer biology and precision cancer therapy.Nat Rev Cancer. 2020 Apr 06;:Authors: Fazio M, Ablain J, Chuan Y, Langenau DM, Zon LIAbstract In precision oncology, two major strategies are being pursued for predicting clinically relevant tumour behaviours, such as treatment response and emergence of drug resistance: inference based on genomic, transcriptomic, epigenomic and/or...
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Machine Learning in Oncology: A Clinical Appraisal.: Related ArticlesMachine Learning in Oncology: A Clinical Appraisal.Cancer Lett. 2020 Apr 03;:Authors: Cuocolo R, Caruso M, Perillo T, Ugga L, Petretta MAbstract Machine learning (ML) is a branch of artificial intelligence centered on algorithms which do not need explicit prior programming to function but automatically learn from available data, creating decision models to complete tasks. ML-based tools have numerous promising applications...
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The association between BMI and health-related physical fitness among Chinese college students: a cross-sectional study.: Related ArticlesThe association between BMI and health-related physical fitness among Chinese college students: a cross-sectional study.BMC Public Health. 2020 Apr 05;20(1):444Authors: Chen X, Cui J, Zhang Y, Peng WAbstract BACKGROUND: Existing studies reporting on the levels of physical fitness among college students used relatively few fitness tests as a reflection of...
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Characterization of visceral leishmaniasis outbreak, Marsabit County, Kenya, 2014.: Related ArticlesCharacterization of visceral leishmaniasis outbreak, Marsabit County, Kenya, 2014.BMC Public Health. 2020 Apr 05;20(1):446Authors: Kanyina EWAbstract BACKGROUND: Visceral leishmaniasis (VL) is caused by protozoa of the Leishmania donovani complex. Annually, an estimated 500,000 cases of VL are reported globally posing a public health challenge. The objectives of our study were to confirm and...
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Association of Serum Uric Acid with cardio-metabolic risk factors and metabolic syndrome in seafarers working on tankers.: Related ArticlesAssociation of Serum Uric Acid with cardio-metabolic risk factors and metabolic syndrome in seafarers working on tankers.BMC Public Health. 2020 Apr 05;20(1):442Authors: Baygi F, Herttua K, Sheidaei A, Ahmadvand A, Jensen OCAbstract BACKGROUND: There is still controversy over the clinical interpretation of the association between metabolic syndrome (MetS)...
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Household presentation of acute gastroenteritis in a primary care sentinel network: retrospective database studies.: Related ArticlesHousehold presentation of acute gastroenteritis in a primary care sentinel network: retrospective database studies.BMC Public Health. 2020 Apr 05;20(1):445Authors: de Lusignan S, Sherlock J, Ferreira F, O'Brien S, Joy MAbstract BACKGROUND: Acute gastroenteritis (AGE) is a highly transmissible condition spreading rapidly between individuals and within households....
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Prevalence of primary headache disorders among information technology staff in China: the negative effects of computer use and other correlative factors.: Related ArticlesPrevalence of primary headache disorders among information technology staff in China: the negative effects of computer use and other correlative factors.BMC Public Health. 2020 Apr 05;20(1):443Authors: Li C, Zhang L, Zhou J, Fan Z, Wang Y, Wang X, Wang W, Yu SAbstract BACKGROUND: To date, there have been very few studies...
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In situ reconstruction of vascular inflow/outflow to left lateral liver section, ex-vivo liver resection and autologous liver transplantation of remaining liver remnant for hepatic alveolar echinococcosis.: Related ArticlesIn situ reconstruction of vascular inflow/outflow to left lateral liver section, ex-vivo liver resection and autologous liver transplantation of remaining liver remnant for hepatic alveolar echinococcosis.Int J Surg Case Rep. 2020 Mar 28;69:39-43Authors: Zhang Y, Lai ECH, Yang...
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Surgical Removal of a Calcified Right Atrial Mass Related to Venous Access port: A Case Report.: Related ArticlesSurgical Removal of a Calcified Right Atrial Mass Related to Venous Access port: A Case Report.Int J Surg Case Rep. 2020 Mar 31;69:44-47Authors: Brungardt JG, Kasi AK, Kramer JBAbstract INTRODUCTION: Intracardiac masses pose a difficult diagnostic and therapeutic dilemma. Indwelling catheters can lead to thrombus calcification causing untoward sequelae. CASE PRESENTATION:...
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Pneumorrachis and pneumocephalus associated with neck injury after stabbing.: Related ArticlesPneumorrachis and pneumocephalus associated with neck injury after stabbing.Int J Surg Case Rep. 2020 Feb 19;69:48-50Authors: Akgul MHAbstract BACKGROUND: Trauma-related pneumocephalus and subcutaneous emphysema are relatively common, but pneumocephalus and pneumorrachis that occur without surgery are very rare. We present a case of pneumorrachis and pnemocephalus developing in the literature for...
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PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma.: Related ArticlesPLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma.Bone. 2020 Apr 03;:115353Authors: Smeester BA, Slipek NJ, Pomeroy EJ, Laoharawee K, Osum SH, Larsson AT, Williams KB, Stratton N, Yamamoto K, Peterson JJ, Rathe SK, Mills LJ, Hudson WA, Crosby MR, Wang M,...
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Comparison of clinical outcomes and characteristics between patients with and without hypertension in moyamoya disease.: Related ArticlesComparison of clinical outcomes and characteristics between patients with and without hypertension in moyamoya disease.J Clin Neurosci. 2020 Apr 02;:Authors: Ma Y, Zhao M, Deng X, Zhang D, Wang S, Zeng Z, Zhang Q, Zhao JAbstract OBJECTIVE: Our study aimed to compare the disparity of patients with moyamoya disease (MMD) between hypertension group and non-hypertension...
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Patient-reported responses to medical treatment in primary dystonia.: Related ArticlesPatient-reported responses to medical treatment in primary dystonia.J Clin Neurosci. 2020 Apr 02;:Authors: Woo KA, Kim HJ, Yoo D, Choi JH, Shin J, Park S, Kim R, Jeon BAbstract In the absence of pathogenesis-targeted therapy in most types of primary dystonia, the current management strategy is largely symptomatic. Our aim was to comparatively evaluate the patients' perception of symptomatic benefits with...
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Patient-reported responses to medical treatment in primary dystonia.: Related ArticlesPatient-reported responses to medical treatment in primary dystonia.J Clin Neurosci. 2020 Apr 02;:Authors: Woo KA, Kim HJ, Yoo D, Choi JH, Shin J, Park S, Kim R, Jeon BAbstract In the absence of pathogenesis-targeted therapy in most types of primary dystonia, the current management strategy is largely symptomatic. Our aim was to comparatively evaluate the patients' perception of symptomatic benefits with...
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