Defective expression of the peroxisome regulators PPARα receptors and lysogenesis with increased cellular senescence in the venous wall of chronic venous disorder

xlomafota13 shared this article with you from Inoreader Defective expression of the peroxisome regulators PPARα receptors and lysogenesis with increased cellular senescence in the venous wall of chronic venous disorder Via Cellular and Molecular Biology Histol Histopathol. 2021 Mar 1:18322. doi: 10.14670/HH-18-322. Online ahead of print. ABSTRACT The pathogenesis of chronic venous disorder (CVeD) remains partially understood. A marked wall remodeling has been shown with potential accelerated tissue senescence. We have investigated the expression of peroxisome proliferator-activated receptor (PPAR) isoforms transcription factor EB (TFEB) as regulatory molecules of cellular homeostasis and makers of peroxisomal and lysosomal biogenesis. We have also quantified p16 expression as a cellular senescence marker. In specimens of maior safena vein from 35 CVeD and 27 healthy venous controls (HV), we studied the expression of PPAR-α, PPAR-β/δ, PPAR-γ, TFEB and p16 by RT-qPCR and immunohistochemical techniques. We have demonstrated a reduced gene and protein expression of the PPAR-α and PPAR-β/δ isoform as well as that of TFEB in the venous wall of CVeD patients, suggesting an altered per oxisomal and lysosomal biogenesis associated with an increased cellular senescence shown by increased p16 expression. PMID:33645625 | DOI:10.14670/HH-18-322 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Revision of cartilage tympanoplasty with endoscopic butterfly inlay myringoplasty

xlomafota13 shared this article with you from Inoreader Revision of cartilage tympanoplasty with endoscopic butterfly inlay myringoplasty Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Mar 1. doi: 10.1007/s00405-021-06669-w. Online ahead of print. ABSTRACT PURPOSE: While the use of cartilage graft for revision tympanoplasty is quite common, the data on the revision of cartilage tympanoplasty are limited. Our study aims to present the results of our patients who underwent endoscopic butterfly inlay myringoplasty for the revision of cartilage tympanoplasty. METHODS: Demographic data, ear sides, perforation locations, graft success rates and hearing results of the patients who underwent endoscopic butterfly inlay myringoplasty for revision of cartilage tympanoplasty between Sep 2017 and Jan 2020 were evaluated. RESULTS: A total of 17 patients with 7 (41%) females and 10 (59%) males were included in our study. Eight of the ears (47%) were right and nine (53%) were left. Perforation locations included ten (59%) anterior, six (35%) inferior, and one (6%) posterior. The graft succ ess rate of our study was 100%. No changes were observed in post-operative air conduction, bone conduction and air-bone gap values compared to the pre-operative period (p > 0.05). CONCLUSIONS: Endoscopic butterfly inlay myringoplasty for the revision of cartilage tympanoplasty is considered to be a safe surgical technique with satisfactory anatomical and hearing results. PMID:33646345 | DOI:10.1007/s00405-021-06669-w View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Survival outcomes of patients with subglottic squamous cell carcinoma : a study of the National Cancer Database

xlomafota13 shared this article with you from Inoreader Survival outcomes of patients with subglottic squamous cell carcinoma : a study of the National Cancer Database Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Mar 1. doi: 10.1007/s00405-021-06712-w. Online ahead of print. ABSTRACT BACKGROUND: Subglottic squamous cell carcinoma (SCC) represents less than 5% of all laryngeal cancers. Our objective was to better characterize survival using the National Cancer Database (NCDB) registry from 2004 to 2015. RESULTS: 403 patients met inclusion criteria. 63.8% presented with advanced-stage disease. Treatment regimens were as follows: 15.9% underwent surgery alone, 16.9% underwent surgery followed by adjuvant therapy, and 67.2% underwent primary chemo/radiation (C/RT). Five-year overall survival (OS) was 58.6% for Stage I and II patients, 49.1% for Stage III, and 36.3% for stage IV. Adjusted OS for all-stage patients was worse with C/RT compared to upfront surgery (40.6% vs. 58.4%; HR 1.83 [95%CI 1.29-2.61] p < 0.001) and adjusted OS for stage 4 disease was significantly worse with C/RT compared to surgery (26.0 % vs. 45.2%, HR 1.79 [95%CI 1.17-2.73] p = 0.007). CONCLUSION: Majority of patients were treated with primary C/RT. Adjusted survival favors upfront surgery versus C/RT, especially in patients with Stage IV disease. PMID:33646344 | DOI:10.1007/s00405-021-06712-w View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Laser treatment of specific scar characteristics in hypertrophic scars and keloid: A systematic review

xlomafota13 shared this article with you from Inoreader Laser treatment of specific scar characteristics in hypertrophic scars and keloid: A systematic review Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Jan;74(1):48-64. doi: 10.1016/j.bjps.2020.08.108. Epub 2020 Sep 20. ABSTRACT BACKGROUND: Hypertrophic scarring and keloid can cause significant emotional and physical discomfort. Cosmetic appearance, functional limitations, pain and pruritus form a degree of impairment. While the etiology is not fully known, there is a wide array of treatment options, which include excision, radiation, cryotherapy, silicone gel sheeting, and intralesional injections. A relatively new modality is laser therapy. While results are promising, the number of different laser systems is substantial. This review evaluates the available evidence regarding outcomes on specific objective characteristics (i.e., erythema, pigmentation, height, and pliability) of the different laser systems. METHODS: A systematic literature review was performed using MEDLINE, Cochrane Library, and EMBASE. Data on scar characteristics were ext racted from scar scales Vancouver Scar Scale (VSS) and Patient and Observer Scar Assessment Scale (POSAS), and from objective measurement tools. RESULTS: Heterogeneity was seen in a lot of aspects: maturity of scar, origin of scar, follow-up, and number of treatments. The fractional ablative lasers CO2 10,600 nm and Er:YAG 2940 nm were found to produce the best results regarding erythema, height, and pliability, while the flash lamp-pumped pulsed dye laser (PDL) 585 nm scored slightly below that. CONCLUSIONS: Laser systems, and specifically the fractional ablative lasers CO2 and Er:YAG, improved various characteristics of excessive scarring. An overview of preferred laser modality per scar characteristic is presented. Accounting for the methodological quality and the level of evidence of the data, future research in the form of randomized trials with comparable standardized scar scales is needed to confirm these results. PMID:33645505 | DOI:10.1016/j.bjps.2020.08.108 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Voice Disorders Detection Through Multiband Cepstral Features of Sustained Vowel

xlomafota13 shared this article with you from Inoreader Voice Disorders Detection Through Multiband Cepstral Features of Sustained Vowel Via Journal of Voice This study aims to detect voice disorders related to vocal fold nodule, Reinke's edema and neurological pathologies through multiband cepstral features of the sustained vowel /a/. Detection is performed between pairs of study groups and multiband analysis is accomplished using the wavelet transform. For each pair of groups, a parameters selection is carried out. Time series of the selected parameters are used as input for four classifiers with leave-one-out cross validation. Classification accuracies of 100% are achieved for all pairs including the control group, surpassing the state-of-art methods based on cepstral features, while accuracies higher than 88.50% are obtained for the pathological pairs. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The German Restructured Vocal Fatigue Index and Characteristics of Dysphonic and Vocally Healthy Populations

xlomafota13 shared this article with you from Inoreader The German Restructured Vocal Fatigue Index and Characteristics of Dysphonic and Vocally Healthy Populations Via Journal of Voice The Vocal Fatigue Index (VFI), a 19-item psychometric self-report questionnaire, enables individuals with vocal fatigue (VF) to be identified and their complaints to be characterized. The purpose of this study was to improve the German-language version (VFI-G) and to evaluate further vocal fatigue-related characteristics of dysphonic and control populations. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Outcomes of tympanoplasty in a low resource setting: Our experience

xlomafota13 shared this article with you from Inoreader Outcomes of tympanoplasty in a low resource setting: Our experience in 429 ears in Cambodia Via Clinical Otolaryngology Abstract Tympanoplasty outcomes are well established in high income nations, but less reported in low‐middle income countries (LMICs). LMICs see a higher prevalence of chronic suppurative otitis media, with anecdotal evidence of greater disease severity at presentation. Here we find that tympanoplasty performed by local surgeons in the LMIC of Cambodia has 85.8% successful closure, which is comparable to other settings. For audiological outcomes, there was a mean reduction in the air‐bone gap of 15.8dB, and improvement in the air‐conduction average in 85.5% of participants. We find no evidence that tympanoplasty outcomes in LMICs should differ from those in other settings. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Impedance‐pH monitoring Profile of Patients with Reflux and Obstructive Sleep Apnea Syndrome: A Controlled Study

xlomafota13 shared this article with you from Inoreader Impedance‐pH monitoring Profile of Patients with Reflux and Obstructive Sleep Apnea Syndrome: A Controlled Study Via Clinical Otolaryngology Abstract Objective To study the profile of patients with obstructive sleep apnea syndrome (OSAS) and laryngopharyngeal reflux (LPR) at the hypopharyngeal‐esophageal multichannel intraluminal impedance‐pH monitoring (HEMII‐pH) and to compare their reflux findings with LPR patients without OSAS. Design Prospective controlled study. Methods Patients with LPR and OSAS were prospectively recruited from Augustus 2019 to June 2020. The profile of hypopharyngeal reflux events (HRE) of patients was studied through a breakdown of the HEMII‐pH findings over the 24‐hour of testing. Reflux symptom score (RSS), gastrointestinal and HEMII‐pH outcomes were compared between LPR patients and patients with LPR and OSAS. Multivariate analysis was used to study the relationship between reflux data and the following sleep outcomes: Apnea‐Hypopnea Index, Epworth Slippiness Scale (ESS) and paradoxical sleep data. Results A total of 89 patients completed the study. There were 45 patients with LPR and 44 subjects with both OSAS and LPR. The numbers of upright and daytime HREs and the otolaryngological RSS were significantly higher in patients with LPR compared with those with OSAS and LPR. There was a significant positive association between RSS quality of life score and ESS (p=0.001). The occurrence of HREs in the evening was associated with higher ESS (p=0.015). Patients with OSAS, LPR and GERD had higher number of nocturnal HREs compared with those without GERD (p=0.001). Conclusion The presence of OSAS in LPR patients is associated with less severe HEMII‐pH and ear, nose and throat symptoms. There may have different OSAS patient profiles according to the occurrence of GERD. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Learning curve in Endoscopic Tympanoplasties: a prospective study based on outcomes of 141 cases

xlomafota13 shared this article with you from Inoreader Learning curve in Endoscopic Tympanoplasties: a prospective study based on outcomes of 141 cases Via Clinical Otolaryngology Abstract The overall success rate for TEES tympanoplasty was 83% A learning curve of approximately 60 cases was evident, with success in the final 33% of cases being 93.5% The only significant factor affecting the tympanoplasty success rate was the year since starting TEES. Hearing outcomes are related to pre‐operative ABG, ossicle erosion, and COM risk factors, but not to the level of experience in TEES. TEES has comparable outcomes, efficacy and complications to microscopic or combined techniques View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

To Compare and Evaluate Laryngeal Changes in Patients with Dysphonia in Laryngopharyngeal Reflux (LPR) before and after Treatment with Proton Pump Inhibitors (PPI) and Prokinetic Drugs

xlomafota13 shared this article with you from Inoreader To Compare and Evaluate Laryngeal Changes in Patients with Dysphonia in Laryngopharyngeal Reflux (LPR) before and after Treatment with Proton Pump Inhibitors (PPI) and Prokinetic Drugs Via Otolaryngology Indian Abstract To evaluate and compare pre and post treatment results using the following parameters by (a) Dual probe pH monitoring. (b) Laryngeal mucosal changes as assessed by direct video laryngoscopy/stroboscopy using Belafsky scores. (c) Voice changes by using GRBAS and Dr Speech software for speech analysis. In our study we have evaluated and compared voice and laryngeal changes in patients with dysphonia and RSI > 10 (which is suggestive of LPR) before treatment and after 6 months of treatment with Tab. Pantoprazole and Tab. Mosapride. This prospective study was carried out on 50 patients attending the ENT OPD of a tertiary care referral centre over a period of 18 months i.e. from Nov 2008 to Apr 2010. The study showed that prolonged therapy (> 6 months) is required to treat LPR effectively and 24 h ambulatory dual probe pH metry and videolaryngoscopy to assess RFS are the most preferred diagnostic tools in LPR. Dr Speech software for voi ce analysis can give an objective assessment of voice changes in LPR before and after treatment. The treatment consisting of PPI and prokinetic drugs proved to be effective in laryngopharyngeal reflux disease as improvement was seen in all the parameters including reflux findings score, subjective and objective voice assessment. According to results of our study, 24 h ambulatory dual probe pH metry, Reflux Finding Score (RFS), subjective and objective acoustic parameters can be used as indicators of efficacy of treatment. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Orbital Surgical Guidelines: Pediatric Considerations

xlomafota13 shared this article with you from Inoreader Orbital Surgical Guidelines: Pediatric Considerations Via Journal of Neurological Surgery Part B: Skull Base J Neurol Surg B Skull Base DOI: 10.1055/s-0040-1722637 Pediatric orbital and skull base surgery comprises a wide array of tumors. An understanding of the location of the lesion, nature of the disease, and surrounding anatomy is paramount to surgical planning in these small spaces. The goals of pediatric skull base surgery are to avoid injury to the surrounding structures, minimize cosmetic deformities, and remove some or all of the tumors based on anticipated pathology and biologic cost of removal. Safe surgery on many of these tumors requires an understanding of the location of the lesion relative to the optic nerve or orbit. This is particularly challenging because the dimensions of the orbital confines change continuously as one navigates from rostral to caudal. Management of these tumors may require a multidisciplinary approach including orbital surgery, neurosurgery, otolaryngology, oral maxillofacial surgery, plastic surgery, and interventiona l neuroradiology. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Facial Nerve Function Outcome and Risk Factors in Resection of Large Cystic Vestibular Schwannomas

xlomafota13 shared this article with you from Inoreader Facial Nerve Function Outcome and Risk Factors in Resection of Large Cystic Vestibular Schwannomas Via Journal of Neurological Surgery Part B: Skull Base J Neurol Surg B Skull Base DOI: 10.1055/s-0041-1725028 Objective Cystic vestibular schwannomas (VS) in contrast to solid VS tend to have accelerated growth, larger volume, rapid/atypical presentation, lobulated/adherent surface, and unpredictable course of the cranial nerves. Cystic VS are surgically challenging, with worse clinical outcomes and higher rate of subtotal resection (STR). Methods We retrospectively analyzed postoperative outcomes of 125 patients with cystic VS, operated between years 2005 and 2019 in our center. We confronted the extent of the resection and House-Brackmann (HB) grade of facial palsy with the results of comparable cohort of patients with solid VS operated in our center and literature review by Thakur et al.1 Results Translabyrinthine approach was preferred for resection of large, cystic VS (97.6%). Gross-total resection (GTR) was achieved in 78 patients (62.4%), near-total resection (NTR) with remnant (<4 × 4 × 2 mm) in 43 patients (34.4%), and STR in 4 patients (3.2%). NTR/STR were significantly associated with higher age, tumor volume >5 cm3, retrosigmoid approach, high-riding jugular bulb, tumor adherence to the brain stem, and facial nerve (p = 0.016; 0.003; 0.005; 0.025; 0.001; and <0.00001, respectively).One year after the surgery, 76% of patients had HB grades 1 to 2, 16% had HB grades 3 to 4, and 8% had HB grades 5 to 6 palsy. Worse outcome (HB grades 3 to 6) was associated with preoperative facial palsy, tumor volume >25 cm3, and cyst over the brain stem (p = 0.045; 0.014; and 0.05, respectively). Comparable solid VS operated in our center had significantly higher HB grades 1 to 2 rate than our cystic VS (94% versus 76%; p = 0. 03). Comparing our results with literature review, our HB grades 1 to 2 rate was significantly higher (76% versus 39%; p = 0.0001). Tumor control rate 5 years after surgery was 95.8%. Conclusion Our study confirmed that microsurgery of cystic VS has worse outcomes of facial nerve preservation and extent of resection compared with solid VS. Greater attention should be paid to the above-mentioned risk factors. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.