heory of COVID-19 pathogenesis
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki
Wed Sep 16, 2020 18:30
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): L. John Gagliardi, Daniel H. Shain
Wed Sep 16, 2020 18:30
Lipomas are rare primary heart tumors and may involve the endocardium, myocardium, or pericardium. Signs and symptoms depend on the tumor location and size. The intrapericardial lipoma we report has massive dimensions and mimics a pericardial effusion. A 38-year-old male complained of dyspnea and precordial pain. On physical examination, heart sounds were diminished. The patient had received extensive medication for a clinically suspected pericardial effusion due to heart failure. A voluminous mass...
Wed Sep 16, 2020 09:50
This piece is part of an SEAA series on “An Anthropology of Ethics in East Asia.” The articles examine how individuals cope with societal changes such as environmental crises, nationalism, economic development, and mobility through a lens of everyday ethics. As a life-sustaining treatment for patients suffering from kidney failure, hemodialysis has been ridden with controversies since its emergence. It is a “half-way technology” that can neither cure the disease nor provide a sense of comfort,...
Wed Sep 16, 2020 18:00
Publication date: Available online 16 September 2020Source: Practical Radiation OncologyAuthor(s): Dean A. Shumway, Nirav Kapadia, Eleanor M. Walker, Kent A. Griffith, Thy Thy Do, Mary Feng, Thomas Boike, Yolanda Helfrich, Bonnie DePalma, Erin F. Gillespie, Alexandria Miller, James Hayman, Reshma Jagsi, Lori J. Pierce
Wed Sep 16, 2020 18:59
Publication date: Available online 16 September 2020Source: Practical Radiation OncologyAuthor(s): Michael D. Chuong, John Bryant, Kathryn E. Mittauer, Matthew Hall, Rupesh Kotecha, Diane Alvarez, Tino Romaguera, Muni Rubens, Sonia Adamson, Andrew Godley, Vivek Mishra, Gustavo Luciani, Alonso N. Gutierrez
Wed Sep 16, 2020 18:59
Publication date: Available online 15 September 2020Source: Journal of Surgical EducationAuthor(s): Mollie R. Freedman-Weiss, Danielle R. Heller, Erin M. White, Alexander S. Chiu, Raymond A. Jean, Peter S. Yoo
Wed Sep 16, 2020 19:22
Publication date: Available online 15 September 2020Source: Journal of Surgical EducationAuthor(s): Abbey Kruper, Amy Domeyer-Klenske, Robert Treat, Alicia Pilarski, Kristina Kaljo
Wed Sep 16, 2020 19:22
Publication date: Available online 15 September 2020Source: Journal of Surgical EducationAuthor(s): Varina R. Clark, Laura E. Flores, Jacobien H.F. Oosterhoff, Harriet W. Hopf, Julie K. Silver
Wed Sep 16, 2020 19:22
Publication date: Available online 16 September 2020Source: Journal of Surgical EducationAuthor(s): Kendrick M. Wang, Benjamin Lee, Fasika A. Woreta, Saraswathy Ramanathan, Eric L. Singman, Jing Tian, Divya Srikumaran
Wed Sep 16, 2020 19:22
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02805
Wed Sep 16, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01687
Wed Sep 16, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07745
Wed Sep 16, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04911
Wed Sep 16, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06016
Wed Sep 16, 2020 07:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01437K, PaperQingbo Yang, Alexandre Cristea, Charles Roberts, Kun Liu, Yang Song, Hai Xiao, Honglan Shi, Yinfa MaSingle-cell analysis is an emerging research area that aims to reveal delicate cellular status and underlying mechanisms by conquering the intercellular heterogeneity. Current single-cell research methods, however, are highly dependent...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Sep 16, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01653E, CommunicationJialun Chen, Fangqin Xue, Zhonghua Yu, Lingting Huang, Dianping TangA highly compressible and all-solid-state polydimethylsiloxane (PDMS) sponge-based flexible capacitance sensor modified with polypyrrole (PPy) was designed as the signal readout for sensitive immunoassay of prostate-specific antigen (PSA). This system...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Sep 16, 2020 02:00
Understanding the influence of environmental organochlorine pesticides (OCPs) on mitochondrial function in hepatocytes is important in exploring the mechanism of OCPs causing metabolic disorders. This paper presents detailed methods on detecting hepatic mitochondrial function.
Wed Sep 16, 2020 19:59
ObjectiveRecent evidence has accumulated that the immune system is intimately intertwined with cancer development. Two key characteristics of carcinogens in which the immune system plays a central role are chronic inflammation and immunosuppression. In this systematic review, we investigated the association of chronic inflammatory and immunosuppressive outcomes with benzene, a widely used industrial chemical. Benzene has been confirmed to cause acute myeloid leukaemia and suspected to cause non-Hodgkin...
Wed Sep 16, 2020 19:03
Pancreatic cancer remains a lethal type of cancer with poor prognosis. Molecular classification enables in-depth, precise prognostic assessment. This study is aimed at identifying a robust and simple mRNA signature to predict the overall survival (OS) of pancreatic cancer (PC) patients. Differentially expressed genes (DEGs) between 45 paired pancreatic tumor samples and adjacent healthy tissues were selected. For risk determination, a LASSO Cox regression model with DEGs was used to generate the...
Wed Sep 16, 2020 09:05
Background. CD147/basigin (Bsg), a transmembrane glycoprotein, activates matrix metalloproteinases and promotes inflammation. Objective. The aim of this study is to explore the clinical significance of CD147 in the pathogenesis of inflammatory bowel disease (IBD). Results. In addition to monocytes, the clinical analysis showed that there is no significance obtained in leucocyte, neutrophil, eosinophil, basophil, and erythrocyte between IBD and controls. Immunohistochemistry analysis showed that CD147...
Wed Sep 16, 2020 09:05
Objective. To probe into the role of miR-92a in alleviating oxidative stress and apoptosis of alveolar epithelial cell (AEC) injury induced by lipopolysaccharide (LPS) exposure through the Toll-like receptor (TLR) 2/activator protein-1 (AP-1) pathway. Methods. Acute lung injury (ALI) rat model and ALI alveolar epithelial cell model were constructed to inhibit the expression of miR-92a/TLR2/AP-1 in rat and alveolar epithelial cells (AECs), to detect the changes of oxidative stress, inflammatory response,...
Wed Sep 16, 2020 15:20
Publication date: Available online 15 September 2020Source: Dental MaterialsAuthor(s): Benedikt C. Spies, Fei Zhang, Christian Wesemann, Maoyin Li, Martin Rosentritt
Wed Sep 16, 2020 20:18
Publication date: Available online 15 September 2020Source: Dental MaterialsAuthor(s): Antonin Tichy, Marek Brabec, Pavel Bradna, Keiichi Hosaka, Junji Tagami
Wed Sep 16, 2020 20:18
Transposable elements (TEs) are selfish genomic parasites whose ability to spread autonomously is facilitated by sexual reproduction in their hosts. If hosts become obligately asexual, TE frequencies and dynamics are predicted to change dramatically, but the long-term outcome is unclear. Here, we test current theory using whole-genome sequence data from eight species of bdelloid rotifers, a class of invertebrates where males are thus far unknown. Contrary to expectations, we find a diverse range...
Wed Sep 16, 2020 03:00
Publication date: December 2020Source: NeuroImage, Volume 223Author(s): Mattia F. Pagnotta, David Pascucci, Gijs Plomp
Wed Sep 16, 2020 20:26
Publication date: December 2020Source: NeuroImage, Volume 223Author(s): John F. Magnotti, Zhengjia Wang, Michael S. Beauchamp
Wed Sep 16, 2020 20:26
Publication date: December 2020Source: NeuroImage, Volume 223Author(s): Philip E. Mosley, Katherine Robinson, Terry Coyne, Peter Silburn, Megan S. Barker, Michael Breakspear, Gail A. Robinson, Alistair Perry
Wed Sep 16, 2020 20:26
Publication date: December 2020Source: NeuroImage, Volume 223Author(s): Sivayini Kandeepan, Jorge Rudas, Francisco Gomez, Bobby Stojanoski, Sreeram Valluri, Adrian Mark Owen, Lorina Naci, Emily Sophia Nichols, Andrea Soddu
Wed Sep 16, 2020 20:26
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Tue Sep 15, 2020 10:00
Publication date: November 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 138Author(s): Priyanka Reddy, Young Jae Byun, Jaye Downs, Shaun A. Nguyen, David R. White
Wed Sep 16, 2020 20:35
The increase in antimicrobial resistance is of worldwide concern. Surrogate tracers attempt to simulate microbial transmission by avoiding the infectious risks associated with live organisms. We evaluated sili...
Wed Sep 16, 2020 03:00
New research has led to the discovery of world's oldest animal sperm inside a tiny crustacean trapped in amber around 100 million years ago in Myanmar.
Wed Sep 16, 2020 20:10
Exploitation of the protein degradation machinery as a therapeutic strategy to degrade oncogenic proteins is experiencing revolutionary advances with the development of proteolysis targeting chimeras (PROTACs)...
Tue Sep 15, 2020 03:00
Recently, the focus of enhancing tumor radiosensitivity has shifted from chemotherapeutics to targeted therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are a novel class of selective cell cycle t...
Tue Sep 15, 2020 03:00
Live imaging of lysosomal exocytosis on micropatterned cells allows a spatial quantification of this process. Morphology normalization using micropatterns is an outstanding tool to uncover general rules about the spatial distribution of cellular processes.
Wed Sep 16, 2020 21:00
This letter notifies the readers of the Dysphagia journal of an error in the original published version of this manuscript, for which a previously available open source spreadsheet tool had been used to calculate the position of the hyoid bone or larynx on lateral view videofluoroscopic images. An error in the mathematical formula built into the spreadsheet resulted in a reversal of the results for the X and Y planes of measurement. This erratum provides corrections to the results and interpretations...
Wed Sep 16, 2020 03:00
This erratum notifies the readers of the Dysphagia journal of an error in the original published version of this manuscript. In that manuscript, a previously available open source spreadsheet tool was used to calculate the position of the posterior laryngeal air column on lateral view videofluoroscopic images as a proxy for the bottom of the pharynx. We have subsequently been made aware of an error in the mathematical formula built into the spreadsheet, which resulted in a reversal of the results...
Wed Sep 16, 2020 03:00
Otosclerosis (OS) occurs as a result of impaired bone remodeling in otic capsule (labyrinthine) and stapes footplate which might present clinically in form of conductive hearing loss. Surgical treatment and stapedotomy are the most promising treatment. Fisch, described that the early fenestration in “reversal stapedotomy” reduces the risk of a floating footplate.In this study we evaluated efficacy of reversal stapedotomy technique amongst 74 OS patients and considered associated factors for better...
Wed Sep 16, 2020 03:00
Invaders, pirates, warriors - the history books taught us that Vikings were brutal predators who travelled by sea from Scandinavia to pillage and raid their way across Europe and beyond. Now cutting-edge DNA sequencing of more than 400 Viking skeletons from archaeological sites scattered across Europe and Greenland will rewrite the history books.
Wed Sep 16, 2020 18:35
Publication date: Available online 16 September 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Takako Okawachi, Kiyohide Ishihata, Namiko Nomoto, Masahiro Tezuka, Yuhei Kamikuri, Etsuro Nozoe, Norifumi Nakamura
Wed Sep 16, 2020 21:43
“Silos,” an agricultural analogy referencing self-contained grain storage units, is frequently applied to groups, organizations, disciplinary knowledge, and institutional types to reflect differences in association or affiliation with accompanying differences (perceived or actual) in perspectives and behavior. Within anthropology, for example: one group of anthropologists works in practice while their colleagues work in the academy; another group enjoys tenure while lecturers and adjuncts are...
Wed Sep 16, 2020 21:00
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): Ahmed Shaaban, Arun Babu R, Rasha G. Elbadry, Rizq Haddad, Issam Al-Bozom, Ali Ayyad, Sirajeddin Belkhair
Wed Sep 16, 2020 22:04
Publication date: December 2020Source: World Neurosurgery, Volume 144Author(s): Pravin Salunke, Apinderpreet Singh, Madhivanan Karthigeyan
Wed Sep 16, 2020 22:04
Delayed-union or non-union between a host bone and a graft is problematic in clinical treatment of segmental bone defects in orthopedic cases. Based on a preliminary study of human periosteum allografts from this laboratory, the present work has extensively investigated the use of human cadaveric tissue-engineered periosteum-allograft constructs as an approach to healing such serious orthopedic surgical situations. In this current report, human cadaveric periosteum-wrapped bone allografts and counterpart...
Wed Sep 16, 2020 15:49
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01231A, CommunicationFeiyue Teng, Xinpei Wu, Tao Hong, Gary Munk, Matthew R. LiberaWe use electron-beam patterned functional microgels to integrate self-reporting molecular beacons, dielectric microlenses, and solid-phase and/or solution-phase nucleic acid amplification in a viral-detection microarray model. The detection limits for different...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Sep 16, 2020 02:00
Publication date: December 2020Source: Cancer Epidemiology, Volume 69Author(s): Charlotta Ekstrand, Shahram Bahmanyar, Honar Cherif, Helle Kieler, Marie Linder
Wed Sep 16, 2020 22:38
New research finds that the traits that make vertebrates distinct from invertebrates were made possible by the emergence of a new set of genes 500 million years ago, documenting an important episode in evolution where new genes played a significant role in the evolution of novel traits in vertebrates.
Wed Sep 16, 2020 20:10
Abstract Trans-nasal endoscopic surgery (TNES) is a helpful diagnostic and therapeutic modality in otorhinolaryngology surgeries and requires controlled hypotension for better visualization of the surgical field. Recent literature shows evidence of intravenous Lignocaine infusion to produce the controlled hypotension. The study aims to assess and compare the effects of Lignocaine (LIG) and Dexmedetomidine (DEX) infusion with respect to surgical field quality. 101 Consenting adult...
Wed Sep 16, 2020 03:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02209
Wed Sep 16, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c03194
Wed Sep 16, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02370
Wed Sep 16, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02782
Wed Sep 16, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02204
Wed Sep 16, 2020 07:00
Omalizumab is an efficient drug for patients with uncontrolled severe allergic asthma (SAA). However, little is known about the differences in omalizumab treatment outcomes among patients with different types ...
Tue Sep 15, 2020 03:00
Eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) exhibits a poorer outcome compared with non-eosinophilic chronic rhinosinusitis with nasal polyps (nonECRSwNP), so it is significant to identify ...
Wed Sep 16, 2020 03:00
Publication date: Available online 15 September 2020Source: European Journal of Surgical OncologyAuthor(s): Kate E. McBride, Daniel Steffens, Michael J. Solomon, Cherry Koh, Nabila Ansari, Christopher J. Young, Brendan Moran
Wed Sep 16, 2020 23:42
Publication date: Available online 16 September 2020Source: European Journal of Surgical OncologyAuthor(s): Tyler R. Chesney, Barbara Haas, Natalie Coburn, Alyson L. Mahar, Laura E. Davis, Victoria Zuk, Haoyu Zhao, Frances Wright, Amy T. Hsu, Julie Hallet, Ines Menjak, Douglas Manuel, Dov Gandell, Lesley Gotlib-Conn
Wed Sep 16, 2020 23:42
Publication date: Available online 16 September 2020Source: European Journal of Surgical OncologyAuthor(s): Tomoyuki Abe, Hironobu Amano, Tsuyoshi Kobayashi, Minoru Hattori, Keiji Hanada, Masahiro Nakahara, Hideki Ohdan, Toshio Noriyuki
Wed Sep 16, 2020 23:42
Publication date: Available online 16 September 2020Source: European Journal of Surgical OncologyAuthor(s): Edward Alabraba, David Mark Pritchard, Rebecca Griffin, Rafael Diaz-Nieto, Melissa Banks, Daniel James Cuthbertson, Stephen Fenwick
Wed Sep 16, 2020 23:42
Abstract The current WHO histopathologic criteria for oral epithelial dysplasia (ED) are based on architectural and cytologic alterations, and do not address other histopathologic features of ED. Here we propose new diagnostic criteria including architectural, organizational, and cytologic features for oral ED. Cases of unifocal leukoplakia (UL) and proliferative leukoplakia (PL) with clinical photographs and follow-up information were identified. Only cases that showed minimal...
Wed Sep 16, 2020 03:00
Abstract Angiomyolipoma (AML) is a mesenchymal tumor commonly found in the kidneys. Extra-renal AML is uncommon and especially rare in the nasal cavity. To our knowledge, fewer than five cases of nasal AML are reported in the United States. We present a case of nasal AML in a 65-year-old man with a history of rhinosinusitis and obstruction of the left nasal cavity. The lesion comprised of admixed spindled smooth muscle cells, mature adipose tissue, and thick-walled blood vessels....
Wed Sep 16, 2020 03:00
If it weren’t for the angled mirrors where the wall meets the ceiling, the toilets would be like any other. Depending on their gender, a male or female clinician will accompany the patient into the toilet, the mirror serving as a kind of periscope to that most everyday of bodily functions: urinating. “The mirrors are there to stop any funny business,” says Sarah. She pauses, cracking a thin smile that sits somewhere between impressed and exhausted. “But that sure don’t stop people trying.” Sarah...
Wed Sep 16, 2020 23:00
Publication date: November 2020Source: Brain and Language, Volume 210Author(s): Nádia Canário, Lília Jorge, Miguel Castelo-Branco
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The purpose of this study was to estimate the effect of platelet-rich fibrin (PRF) on the control of alveolar osteitis (AO), pain, trismus, soft tissue healing, and swelling following mandibular third molar surgery. A comprehensive search of the literature was conducted through PubMed, Embase, Web of Science, and Cochrane Library up to May 2019. Randomized controlled studies conforming to the inclusion criteria were included. The record screening and data extraction were conducted by two authors...
Wed Sep 16, 2020 03:00
An increasing number of biological and epidemiological evidence suggests that c.919-2A > G and c.2168A > G variants of solute carrier family 26, member 4 (SLC26A4) gene play a critical role in the development of ...
Tue Sep 15, 2020 03:00
Insulin-like growth factor 2 (IGF2) messenger RNA binding protein 3 (IMP3) has been testified to be overexpressed in prostate cancer and strongly related to patients’ poor prognosis. However, the functions of ...
Wed Sep 16, 2020 03:00
23 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2020/09/16PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Related Articles Up-regulated ENO1 promotes the bladder cancer cell growth and proliferation via regulating β-catenin. Biosci Rep. 2019 09 30;39(9): Authors: Ji M, Wang Z, Chen J, Gu L, Chen M, Ding Y, Liu T Abstract Bladder cancer (BC) is the ninth most common malignancy throughout the world. The molecular mechanisms of this disease remain largely unclear. The glycolytic enzyme enolase 1 (ENO1) has been shown to regulate the development...
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Related Articles Structural and Biological Basis of Alphacoronavirus nsp1 Associated with Host Proliferation and Immune Evasion. Viruses. 2020 07 28;12(8): Authors: Shen Z, Yang Y, Yang S, Zhang G, Xiao S, Fu ZF, Peng G Abstract Non-structural protein 1 (nsp1) is only characterized in alphacoronaviruses (α-CoVs) and betacoronaviruses (β-CoVs). There have been extensive researches on how the β-CoVs nsp1 regulates viral virulence by inhibiting...
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Related Articles Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma. Cells. 2020 Sep 10;9(9): Authors: Martinikova AS, Burocziova M, Stoyanov M, Macurek L Abstract Genome integrity is protected by the cell-cycle checkpoints that prevent cell proliferation in the presence of DNA damage and allow time for DNA repair. The transient checkpoint arrest together with cellular senescence represent...
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Related Articles Toxoplasma GRA16 Inhibits NF-κB Activation through PP2A-B55 Upregulation in Non-Small-Cell Lung Carcinoma Cells. Int J Mol Sci. 2020 Sep 10;21(18): Authors: Seo SH, Kim SG, Shin JH, Ham DW, Shin EH Abstract Nuclear factor kappa B (NF-κB) activation is a well-known mechanism by which chemoresistance to anticancer agents is reported. It is well-known that irinotecan as a chemotherapeutic drug against non-small-cell lung carcinoma...
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Related Articles A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo. Neoplasia. 2020 Oct;22(10):522-532 Authors: Zhao L, Han X, Lu J, McEachern D, Wang S Abstract The androgen receptor (AR) has been found to be expressed in the majority of human breast cancer and AR antagonists, such as enzalutamide, have shown promising clinical activity...
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Related Articles LINC01133 and LINC01243 are positively correlated with endometrial carcinoma pathogenesis. Arch Gynecol Obstet. 2020 Sep 14;: Authors: Yang W, Yue Y, Yin F, Qi Z, Guo R, Xu Y Abstract PURPOSE: To characterize the role of two long non-coding RNAs (lncRNAs), LINC01133 and LINC01243, in endometrial carcinoma (EC) pathogenesis. LINC01133 is an lncRNA that has been implicated in many cancers, and LINC01243 is a newly identified...
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Related Articles Matrix metalloproteinase-14 (MMP-14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation. Thorac Cancer. 2020 Sep 15;: Authors: Chen N, Zhang G, Fu J, Wu Q Abstract BACKGROUND: Matrix metalloproteinase-14 (MMP-14) is known to be a key regulator of oncogenesis and tumor progression. The present study was designed to assess the relationship between the downregulation of MMP-14...
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Related Articles Oleamide Induces Cell Death in Glioblastoma RG2 Cells by a Cannabinoid Receptor-Independent Mechanism. Neurotox Res. 2020 Sep 15;: Authors: Torres-Román AL, García-Hernández VM, Rangel-López E, Ruiz-García E, Meneses-García A, Santamaría A, Aschner M, Prospero-García O, Ortega-Gómez A Abstract The endocannabinoid system has been associated with antiproliferative effects in several types of tumors through cannabinoid receptor-mediated...
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Related Articles Krill Oil Perturbs Proliferation and Migration of Mouse Colon Cancer Cells in vitro by Impeding Extracellular Signal-Regulated Protein Kinase Signaling Pathway. Lipids. 2020 Sep 15;: Authors: Jing W, Bi Y, Wang G, Zeng S, Han L, Yang H, Wang N, Zhao Y Abstract The prevalence of colorectal cancer (CRC) continues to increase. Treatment of CRC remains a significant clinical challenge, and effective therapies for advanced CRC...
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Related Articles Protoflavones in melanoma therapy: Prooxidant and pro-senescence effect of protoapigenone and its synthetic alkyl derivative in A375 cells. Life Sci. 2020 Sep 12;:118419 Authors: Csekes E, Vágvölgyi M, Hunyadi A, Račková L Abstract AIMS: In our study, the anticancer effects of a semisynthetic p-quinol, protoapigenone 1'-O-butyl ether (PABut), were tested in human melanoma A375 cells also in comparison with natural congener,...
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Related Articles Design, synthesis, and biological evaluation of new challenging thalidomide analogs as potential anticancer immunomodulatory agents. Bioorg Chem. 2020 Sep 01;104:104218 Authors: El-Zahabi MA, Sakr H, El-Adl K, Zayed M, Abdelraheem AS, Eissa SI, Elkady H, Eissa IH Abstract Thalidomide and its analogs are immunomodulatory drugs that inhibit the production of certain inflammatory mediators associated with cancer. In the present...
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Abstract This article follows shorebirds—migratory animals that have gone from game to nongame animals over the course of the past century in North America—as a way to track modern field biology, bureaucratic institutions, and the valuation of wildlife. Doing so allows me to make interrelated arguments about the history of wildlife management and science. The first is to note the endurance of observation-based natural history methods in field biology over the long twentieth century...
Wed Sep 16, 2020 03:00
Related Articles Do Disparities in Sleep Duration Among Racial and Ethnic Minorities Contribute to Differences in Disease Prevalence? J Racial Ethn Health Disparities. 2019 12;6(6):1053-1061 Authors: Chattu VK, Chattu SK, Spence DW, Manzar MD, Burman D, Pandi-Perumal SR Abstract Sleep duration in the USA has declined continually during the second half of the twentieth century, before reaching a plateau in the early twenty-first century. However,...
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Related Articles Association of bariatric surgery with all-cause mortality and incidence of obesity-related disease at a population level: A systematic review and meta-analysis. PLoS Med. 2020 07;17(7):e1003206 Authors: Wiggins T, Guidozzi N, Welbourn R, Ahmed AR, Markar SR Abstract BACKGROUND: Previous clinical trials and institutional studies have demonstrated that surgery for the treatment of obesity (termed bariatric or metabolic surgery)...
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Related Articles Demographic and Clinical Characteristics Associated With Adherence to Guideline-Based Polysomnography in Children With Down Syndrome. Otolaryngol Head Neck Surg. 2020 Sep 15;:194599820954837 Authors: Knollman PD, Heubi CH, Wiley S, Smith DF, Shott SR, Ishman SL, Meinzen-Derr J Abstract OBJECTIVES: To compare the demographic and clinical characteristics of children with Down syndrome who did and did not receive polysomnography...
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Related Articles The effectiveness of a weight-loss Mediterranean diet/lifestyle intervention in the management of obstructive sleep apnea: Results of the "MIMOSA" randomized clinical trial. Clin Nutr. 2020 Sep 06;: Authors: Georgoulis M, Yiannakouris N, Kechribari I, Lamprou K, Perraki E, Vagiakis E, Kontogianni MD Abstract BACKGROUND & AIMS: Although continuous positive airway pressure (CPAP) is the first-line treatment for obstructive...
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Related Articles Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial. BMJ Open Respir Res. 2020 Sep;7(1): Authors: Tang I, Turnbull CD, Sen D, Craig S, Kohler M, Stradling JR Abstract The effect of continuous positive airway pressure (CPAP) on cardiovascular events is uncertain in minimally symptomatic obstructive sleep apnoea. Previous 2-year follow-up data from...
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Related Articles Sleep-disordered breathing in patients on opioids for chronic pain. Reg Anesth Pain Med. 2020 Sep 14;: Authors: Selvanathan J, Peng PWH, Wong J, Ryan CM, Chung F Abstract The past two decades has seen a substantial rise in the use of opioids for chronic pain, along with opioid-related mortality and adverse effects. A contributor to opioid-associated mortality is the high prevalence of moderate/severe sleep-disordered breathing,...
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Related Articles A scalable method of determining physiological endotypes of sleep apnea from a polysomnographic sleep study. Sleep. 2020 Sep 15;: Authors: Finnsson E, Ãlafsdóttir GH, Loftsdóttir DL, Jónsson SÃ, Helgadóttir H, Ãgústsson JS, Sands SA, Wellman A Abstract Sleep apnea is caused by several endophenotypic traits, namely pharyngeal collapsibility, poor muscle compensation, ventilatory instability (high loop gain), and arousability...
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Related Articles Cost-effectiveness Analysis of Preoperative Screening Strategies for Obstructive Sleep Apnea among Patients Undergoing Elective Inpatient Surgery. Anesthesiology. 2020 Oct 01;133(4):787-800 Authors: Sankar A, Dixon PR, Sivanathan L, Memtsoudis SG, de Almeida JR, Singh M Abstract BACKGROUND: Obstructive sleep apnea is underdiagnosed in surgical patients. The cost-effectiveness of obstructive sleep apnea screening is unknown....
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Related Articles Benefits of Treating Obstructive Sleep Apnea. JAMA. 2020 Sep 15;324(11):1110 Authors: Hunasikatti M PMID: 32930751 [PubMed - as supplied by publisher]
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Related Articles Benefits of Treating Obstructive Sleep Apnea-Reply. JAMA. 2020 Sep 15;324(11):1110-1111 Authors: Gottlieb DJ, Punjabi NM PMID: 32930754 [PubMed - as supplied by publisher]
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Related Articles Machine learning for nocturnal mass diagnosis of atrial fibrillation in a population at risk of sleep-disordered breathing. Physiol Meas. 2020 Sep 15;: Authors: Chocron A, Efraim R, Mandel F, Rueschman M, Palmius N, Penzel T, Elbaz M, Behar J Abstract OBJECTIVE: In this research, we introduce a new methodology for atrial fibrillation (AF) diagnosis during sleep in a large population sample at risk of sleep-disordered breathing....
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The evolution of mate preferences may depend on natural selection acting on the mating cues and on the underlying genetic architecture. While the evolution of assortative mating with respect to locally adapted traits has been well-characterized, the evolution of disassortative mating is poorly characterized. Here we aim at understanding the evolution of disassortative mating for traits under strong balancing selection, by focusing on polymorphic mimicry as an illustrative example. Positive frequency-dependent...
Wed Sep 16, 2020 03:00
Efficient optimization of a peptide lead into a drug candidate frequently needs further transformation to augment properties such as bioavailability. Among the different options, foldamers, sequence‐based oligomers with precise folded conformation, have emerged as a promising technology. Here, we introduce oligourea foldamers to reduce the peptide character of inhibitors of protein‐protein interactions (PPI). However, the precise design of such mimics is currently limited by the lack of structural...
Wed Sep 16, 2020 12:01
Molecular silicon polycations of the types R 2 Si 2+ and RSi 3+ (R = H, organic groups) are elusive Lewis superacids and currently unknown in the condensed phase. Here, we report the synthesis of a series of isolable terpyridine‐stabilized R 2 Si 2+ and RSi 3+ complexes, [R 2 Si(terpy)] 2+ (R = Ph 1 2+ ; R 2 = C 12 H 8 2 2+ , (CH 2 ) 3 3 2+ ) and [RSi(terpy)] 3+ (R = Ph 4 3+ , cyclohexyl 5 3+ , m‐xylyl 6 3+ ), in form of their...
Wed Sep 16, 2020 12:25
Zn batteries are usually considered as safe aqueous system promising for flexible batteries. On the other hand, any liquids, including water, being encapsulated in a deformable battery may result in potential troubles. Developing completely liquid‐free all‐solid‐state Zn batteries needs high‐quality solid‐state electrolytes (SSEs). Here, we demonstrate the in‐situ polymerized amorphous solid poly(1,3‐dioxolane) electrolytes, which shows high Zn ion conductivity of 19.6 mS ×cm ‐1 at room temperature,...
Wed Sep 16, 2020 13:29
Transfer hydrogenation (TH) has historically been dominated by Meerwein‐Ponndorf‐Verley (MPV) reactions. However, with growing interest in amine‐boranes, not least ammonia‐borane (H 3 N·BH 3 ), as potential hydrogen storage materials, these compounds have also started to emerge as an alternative reagent in TH reactions. In this review we discuss recent literature into TH chemistry using H 3 N·BH 3 and their analogues (amine‐boranes and metal amidoboranes) as sacrificial hydrogen donors. By...
Wed Sep 16, 2020 14:58
Functionalized polypeptides have attracted tremendous interest in recent years and found many stimulating applications due to their tunable physicochemical characteristics including hydrophilicity and stimuli‐responsive behavior. The development of new strategies to produce these polymers without metallic contaminants is crucial for their applications in high‐value and sensitive domains, such as biomedical, microelectronic, food packaging and personal beauty care fields. Herein, a highly efficient...
Wed Sep 16, 2020 14:59
The utilization of monomeric, lower phosphorous oxides and oxoanions, such as metaphosphite (PO 2 – ), which is the heavier homologue of the common nitrite anion but previously only observed in the gas phase and by matrix isolation, requires new synthetic strategies. Here, a series of rhenium(I‐III) complexes with PO 2 – as ligand is reported. Synthetic access was enabled by selective oxygenation of a terminal phosphide complex. Spectroscopic and computational examination revealed slightly...
Wed Sep 16, 2020 15:30
Visualizing the functional interactions of biomolecules such as proteins and nucleic acids is key to understanding cellular life on the molecular scale. Spatial proximity is often used as a proxy for the direct interaction of biomolecules. However, current techniques to visualize spatial proximity are either limited by spatial resolution, dynamic range, or lack of single‐molecule sensitivity. Here, we introduce Proximity‐PAINT (pPAINT), a variation of the super‐resolution microscopy technique DNA‐PAINT....
Wed Sep 16, 2020 15:35
Amphiphilic molecules, comprising hydrophobic and hydrophilic moieties and the intrinsic propensity to self‐assemble in aqueous environment, sustain a fascinating spectrum of structures and functions ranging from biological membranes to ordinary soap. Facing the challenge to design responsive, adaptive, and out‐of‐equilibrium systems in water, the incorporation of photoresponsive motifs in amphiphilic molecular structures offers ample opportunity to design supramolecular systems that enables functional...
Wed Sep 16, 2020 18:00
A protocol for regio‐controlled hydromagnesiation of 1,3‐enynes was developed using magnesium hydride that is generated in situ by solvothermal treatment of sodium hydride (NaH) and magnesium iodide (MgI 2 ) in THF. The resulting allenylmagnesium species could be converted into tri‐ and tetra‐substituted allenes by subsequent treatment with various carbon‐ and silicon‐based electrophiles with the aid of CuCN as a catalyst.
Wed Sep 16, 2020 18:00
The compositional screening of K‐Zn‐Sb ternary system aided by machine learning, rapid exploratory synthesis using KH salt‐like precursor and in‐situ powder X‐ray diffraction yielded a novel clathrate type XI K 58 Zn 122 Sb 207 . This clathrate consists of a 3D Zn‐Sb framework hosting K + ions inside polyhedral cages, some of which are reminiscent of known clathrate types while others are unique to this structure type. The complex non‐centrosymmetric structure in the tetragonal space group...
Wed Sep 16, 2020 20:01
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