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Macrophage HIF-1{alpha} Is an Independent Prognostic Indicator in Kidney Cancer: Purpose: Clear cell renal cell carcinoma (ccRCC) is frequently associated with inactivation of the von Hippel–Lindau tumor suppressor, resulting in activation of HIF-1α and HIF-2α. The current paradigm, established using mechanistic cell-based studies, supports a tumor promoting role for HIF-2α, and a tumor suppressor role for HIF-1α. However, few studies have comprehensively examined the clinical relevance of this paradigm....
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Radiation with STAT3 Blockade Triggers Dendritic Cell-T cell Interactions in the Glioma Microenvironment and Therapeutic Efficacy: Purpose: Patients with central nervous system (CNS) tumors are typically treated with radiotherapy, but this is not curative and results in the upregulation of phosphorylated STAT3 (p-STAT3), which drives invasion, angiogenesis, and immune suppression. Therefore, we investigated the combined effect of an inhibitor of STAT3 and whole-brain radiotherapy (WBRT) in a murine...
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Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine: Purpose: Rhabdoid tumors are devastating pediatric cancers in need of improved therapies. We sought to identify small molecules that exhibit in vitro and in vivo efficacy against preclinical models of rhabdoid tumor.Experimental Design: We screened eight rhabdoid tumor cell lines with 481 small molecules and compared their sensitivity with that of 879 other cancer cell lines. Genome-scale CRISPR–Cas9 inactivation...
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Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten-deleted Mouse Models of Sarcoma: Purpose: Nanoparticle-encapsulated drug formulations can improve responses to conventional chemotherapy by increasing drug retention within the tumor and by promoting a more effective antitumor immune response than free drug. New drug delivery modalities are needed in sarcomas because they are often chemoresistant cancers, but the rarity of sarcomas and the...
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Editor's Note: The Pivotal Role of Integrin {beta}1 in Metastasis of Head and Neck Squamous Cell Carcinoma:
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Clinical variability in spinal muscular atrophy type III: ObjectiveWe report natural history data in a large cohort of 199 spinal muscular atrophy (SMA) type III patients assessed using the Hammersmith Functional Motor Scale Expanded (HFMSE). The aim of the study was to establish annual rate and possible patterns of progression according to a number of variables, such as age of onset, age at assessment, SMN2 copy number and functional status.MethodsHFMSE longitudinal changes were assessed using piecewise...
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Clinical Balance Testing to Screen for Patients With Vestibular Disorders: A Retrospective Case-control Study: Interventions: All subjects performed Romberg and Jendrassic maneuver with eyes closed (ROMJec), standing on foam with eyes open (SOFeo) and eyes closed (SOFec), Tandem Romberg with eyes open (TReo) and eyes closed (TRec), single leg stance with eyes open (SLSeo) and eyes closed (SLSec), Tandem gait (TG) and Timed Up and Go (TUG).----The patient starts in a seated positionThe patient stands...
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The effectiveness of radiotherapy in the treatment of head and neck mucosal melanoma: Systematic review and meta‐analysis: AbstractIntroductionMucosal melanoma (MM) is a rare condition with a poor prognosis. Surgery is the corner stone of treatment, however, radiotherapy has been commonly employed as a treatment strategy and recent studies suggesting that survival outcomes may be improving are emerging.MethodsA systematic review and meta‐analysis comparing risk ratios of radiotherapy and surgery...
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Prophet forecasting model: a machine learning approach to predict the concentration of air pollutants (PM2.5, PM10, O3, NO2, SO2, CO) in Seoul, South Korea: Amidst recent industrialization in South Korea, Seoul has experienced high levels of air pollution, an issue that is magnified due to a lack of effective air pollution prediction techniques. In this study, the Prophet forecasting model (PFM) was used to predict both short-term and long-term air pollution in Seoul. The air pollutants forecasted...
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TET1 may contribute to hypoxia-induced epithelial to mesenchymal transition of endometrial epithelial cells in endometriosis: Background Endometriosis (EMs) is a non-malignant gynecological disease, whose pathogenesis remains to be clarified. Recent studies have found that hypoxia induces epithelial-mesenchymal transition (EMT) as well as epigenetic modification in EMs. However, the relationship between EMT and demethylation modification under hypoxia status in EMs remains unknown....
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Correlation of Radiologic Versus Endoscopic Visualization of the Middle Ear: Implications for Endoscopic Ear Surgery: Objectives: To determine the limits of visualization during transcanal endoscopic ear surgery (EES) by correlating the relationship between radiologic and endoscopic anatomy using angled optics. Methods: Radiology and endoscopic visualization of tensor fold, protympanum, facial sinus (FS), sinus tympani (ST), subtympanic sinus (STS), hypotympanum, and aditus ad antrum were analyzed...
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Consequences of Mastoidectomy on Bone Conducted Sound Based on Simulations in a Whole Human Head: Hypothesis: The aim of this study is to investigate how a mastoidectomy surgery affects bone conduction (BC) sound transmission using a whole head finite element model. Background: Air conduction (AC) and BC hearing thresholds are normally used to evaluate the effect of an ear surgery. It is then assumed that the BC hearing thresholds are unaffected by the surgery. Moreover, BC hearing aids are used...
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Laterality of Audiovestibular Symptoms Predicts Laterality of Endolymphatic Hydrops in Hydropic Ear Disease (Menière): Background: For clinical confirmation of the diagnosis of hydropic ear disease (HED) (Menière) by MR imaging, two routes of contrast enhancement of the perilymphatic space are currently being used: intratympanic and intravenous. While unilateral intratympanic contrast application generally enables a higher perilymph signal intensity and image quality, the intravenous route allows...
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Visualizing Affected Nerve Bundles of Cranial Nerves VII and VIII in Herpes Zoster Oticus:
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Malformations Associated With Pediatric Congenital Cholesteatomas: Objective: To describe malformations associated with pediatric congenital cholesteatomas of the middle ear. Study Design: Retrospective study. Setting: Tertiary referral center. Patients: One hundred and seventy-three cases of middle ear congenital cholesteatoma (CC) in 171 children operated between 2007 and 2017. Interventions: Demographic, clinical, and surgical data were collected from operative reports. Main Outcome Measures:...
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Natural History of Growing Sporadic Vestibular Schwannomas: An Argument for Continued Observation Despite Documented Growth in Select Cases: Objective: Definitive treatment of sporadic vestibular schwannoma (VS) following documented growth is common practice at most centers in the United States. However, as a natural extension of this paradigm, very little evidence exists surrounding the natural history of growing tumors. The primary objective of the current work was to describe the natural history...
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Long-term survival after cemented versus uncemented total hip arthroplasty for treatment of acute femoral neck fracture: a retrospective study with a mean 10-year follow-up: Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveTo compare the long-term survivorship and Harris hip scores (HHSs) between cemented total hip arthroplasty (CTHA) and uncemented total hip arthroplasty (UTHA) for treatment of acute femoral neck fractures (FNFs).MethodsData of 224 hips (CTHA,...
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A rare case of giant retroperitoneal neurilemmoma: Journal of International Medical Research, Volume 48, Issue 9, September 2020. Neurilemmoma, also known as schwannoma or neurinoma, is a tumor that originates from neural sheath Schwann cells. Giant neurilemmomas derived from the retroperitoneum have rarely been reported. We herein describe a woman with a giant retroperitoneal neurilemmoma that was initially incorrectly diagnosed as an inflammatory abdominal mass. The tumor extended from the patient's...
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Resveratrol prevents TNF-α-induced VCAM-1 and ICAM-1 upregulation in endothelial progenitor cells via reduction of NF-κB activation: Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveTo assess the effects of resveratrol (RSV) on expression of adhesion molecules in endothelial progenitor cells (EPCs) following tumor necrosis factor-α (TNF-α) stimulation.MethodsEPCs were treated with RSV and stimulated with TNF-α. A mononuclear cell (MNC) adhesion assay was used...
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The Nature and Risk Factors of Minimal Associated Pathological Lesions of Vocal Folds at Two Hospitals in the Gulf Area.: The Nature and Risk Factors of Minimal Associated Pathological Lesions of Vocal Folds at Two Hospitals in the Gulf Area.J Voice. 2020 Sep 09;:Authors: Abdelhamid A, Hassan M, Youssef GAbstract OBJECTIVE: To identify the possible risk factors related to etiology of the minimal associated pathological lesions (MAPLs) of the vocal folds and their impacts on the recurrence...
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Current perceptions of 'Brazilian butt lift' (BBL) surgery in the UK: A BAAPS-led survey of BAAPS members.: Current perceptions of 'Brazilian butt lift' (BBL) surgery in the UK: A BAAPS-led survey of BAAPS members.J Plast Reconstr Aesthet Surg. 2020 Aug 26;:Authors: Sadideen H, Akhavani MA, Mosahebi A, Harris PAAbstract BACKGROUND: The BAAPS advice against Brazilian butt lift (BBL) surgery in the UK was set in October 2018. A Delphi study conducted by BAAPS highlighted the importance of...
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Adipose-derived stem cell enrichment is counter-productive for the majority of women seeking primary aesthetic breast augmentation by autologous fat transfer: A systematic review.: Adipose-derived stem cell enrichment is counter-productive for the majority of women seeking primary aesthetic breast augmentation by autologous fat transfer: A systematic review.J Plast Reconstr Aesthet Surg. 2020 Aug 27;:Authors: Lutfi DLD, Turkof ETEAbstract BACKGROUND: Autologous lipotransfer (AL) is a popular...
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Cognitive, language and motor development of infants exposed to risk and protective factors.: Cognitive, language and motor development of infants exposed to risk and protective factors.Int J Pediatr Otorhinolaryngol. 2020 Sep 05;138:110353Authors: Araujo DM, Cabrera Santos DC, Marconi Pinheiro Lima MCAbstract INTRODUCTION: Risk factors are biological or environmental characteristics increasing the likelihood of delays in child development. Meanwhile, protective factors are conditions that...
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Prolonged Survival of a Patient with Chronic Myeloid Leukemia in Accelerated Phase with Recurrent Isolated Central Nervous System Blast Crisis.: Prolonged Survival of a Patient with Chronic Myeloid Leukemia in Accelerated Phase with Recurrent Isolated Central Nervous System Blast Crisis.Am J Case Rep. 2020 Sep 13;21:e922971Authors: Bin Salman AA, Zaidi ARZ, Altaf SY, AlShehry NF, Tailor IK, Motabi IH, Zaidi SZAAbstract BACKGROUND Chronic myeloid leukemia (CML) is usually a tri-phasic myeloproliferative...
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Correlation between the Epworth Sleepiness Scale and the Maintenance of Wakefulness Test in Obstructive Sleep Apnea Patients Treated with Positive Airway Pressure.: Correlation between the Epworth Sleepiness Scale and the Maintenance of Wakefulness Test in Obstructive Sleep Apnea Patients Treated with Positive Airway Pressure.Respir Med Res. 2020 Aug 28;78:100787Authors: Basille D, Baud ME, Andrejak C, Basille-Fantinato A, Jounieaux VAbstract BACKGROUND: The Epworth sleepiness scale (ESS)...
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Iron induces cell death and strengthens the efficacy of anti-androgen therapy in prostate cancer models: Purpose: In search of novel strategies to improve the outcome of advanced prostate cancer (PCa), we considered that PCa cells rearrange iron homeostasis, favoring iron uptake and proliferation. We exploited this adaptation by exposing PCa preclinical models to high-dose iron to induce toxicity and disrupt adaptation to androgen starvation. Experimental Design: We analyzed markers of cell viability...
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Flumatinib versus Imatinib for Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia: A Phase 3, Randomized, Open-label, Multi-center FESTnd Study: Purpose: Flumatinib has been shown to be a more potent inhibitor of BCR-ABL1 tyrosine kinase than imatinib. We evaluated the efficacy and safety of flumatinib versus imatinib, for first-line treatment of chronic phase Philadelphia chromosome-positive chronic myeloid leukemia (CML-CP). Experimental Design: In this study, 394 patients were randomized...
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Immediate inhibition of spinal secretory phospholipase A2 prevents the pain and elevated spinal neuronal hyperexcitability and neuroimmune regulatory genes that develop with nerve root compression: Cervical nerve root injury induces a host of inflammatory mediators in the spinal cord that initiate and maintain neuronal hyperexcitability and pain. Secretory phospholipase A2 (sPLA2) is an enzyme that has been implicated as a mediator of pain onset and maintenance in inflammation and neural injury....
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Eriodictyol produces antidepressant-like effects and ameliorates cognitive impairments induced by chronic stress: Eriodictyol, a natural flavonoid compound identified in numerous medicinal plants, has been reported to have anti-inflammatory, antioxidative and antiproliferative activities and exert protective effects on the neurons, thus drawing attention to its therapeutic potential. However, the effect of eriodictyol on depression remains unclear. In the present study, we investigated the behavioral...
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Electroacupuncture at GV24 and bilateral GB13 improves cognitive ability via influences the levels of Aβ, p-tau (s396) and p-tau (s404) in the hippocampus of Alzheimer's disease model rats: Acupuncture is widely used to treat various neurodegenerative diseases and can effectively improve cognitive and memory states in Alzheimer's disease. However, its mechanism is unclear. We speculated that the effect of acupuncture on cognitive function may be associated with reductions in the levels of Aβ and...
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Minimal incision superficialization of the brachial artery: a technical note: AbstractThe Japanese Society for Dialysis Therapy recommends superficialization of the brachial artery (BA) for vascular access in patients with comorbidities. We describe a novel minimal incision superficialization surgery of a BA through a single small incision. A 78-year-old male, who underwent chronic hemodialysis through an arterio-venous fistula, was transferred to our hospital for treatment of heart failure. We chose...
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Giant benign teratoma occupying the left hemithorax with pleural effusion: a rare presentation: AbstractMature teratomas are the third most common mediastinal tumors. Giant teratoma in pediatric population is rare. A resection of giant benign teratoma in left hemithorax was performed in a 4-year-old patient. The computed tomography scan showed the presence of a large multiloculated mediastinal mass extending to the left pleural space and pleural effusion. The patient underwent total resection of...
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Benign cyst with xanthogranulomatous inflammation involving the transverse colon and the common iliac artery: AbstractXanthogranulomatous inflammation (XGI) is a rare process. Colonic XGI is extremely rare. We present a case report of XGI arising within an intra-abdominal cyst involving the transverse colon. A 28-year-old man presented with abdominal discomfort. He underwent a computed tomography abdomen–pelvis, which found three subcutaneous collections and a large cystic intra-abdominal structure....
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Extended right posterior liver sectionectomy for HCC in a patient with left ventricular assist device—a case report: AbstractSuccessful implementation of left ventricular assist devices lead to a prolonged survival in patients with chronic terminal heart failure. Thus, patients with pre-existing left ventricular assist devices with abdominal comorbidities requiring abdominal surgery, e.g. for malignancy, are upcoming issues. We carried out a major liver resection for hepatocellular carcinoma in a...
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: a case report03:00by Sunakawa T, Ko K, Moriyasu R, et al. via Journal of Surgical Case Reports - current issueAbstractPreoperative diagnosis of cholecystocolonic fistula (CCF) is difficult and the contribution of gallbladder cancer or colon cancer is unclear when there is associated malignancy. We present a case that was diagnosed with acute cholecystitis associated with CCF by multidetector computed tomography (MDCT) preoperatively and malignant neoplasm during emergency surgery. She was finally...
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The efficacy and safety of pertuzumab plus trastuzumab and docetaxel as a first-line therapy in Japanese patients with inoperable or recurrent HER2-positive breast cancer: the COMACHI study.: The efficacy and safety of pertuzumab plus trastuzumab and docetaxel as a first-line therapy in Japanese patients with inoperable or recurrent HER2-positive breast cancer: the COMACHI study.Breast Cancer Res Treat. 2020 Sep 13;:Authors: Takahashi M, Ohtani S, Nagai SE, Takashima S, Yamaguchi M, Tsuneizumi M,...
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Serum cystatin C: A potential predictor for hospital-acquired acute kidney injury in patients with acute exacerbation of COPD: Chronic Respiratory Disease, Volume 17, Issue , January-December 2020. Hospital-acquired acute kidney injury (HA-AKI) is associated with poor prognosis. In this study, we evaluated whether serum cystatin C on admission could predict AKI in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The retrospective study was conducted using data on...
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Management Strategies of Ocular Chemical Burns: Current Perspectives:Abstract: Ocular chemical burns are absolute ophthalmic emergencies and require immediate management to minimize devastating sequelae. Management of alkali and acid burns is started at the scene of the accident by copious irrigation. Treatment is directed at improving epithelial integrity and stromal stability, reduction of undue inflammation, and prevention or timely management of complications. To ascertain the best possible outcome,...
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A Real-World Study of Dexamethasone Implant in Treatment-Naïve Patients with Diabetic Macular Edema: Efficacy and Correlation Between Inflammatory Biomarkers and Treatment Outcome: Purpose: There has been an increasing clinical interest in specific retinal parameters as non-invasive biomarkers of retinal inflammation in diabetic macular edema (DME) that have been shown to have prognostic value, such as hyperreflective retinal fields (HRFs) and subfoveal neuroretinal detachment (SND).Methods: We conducted...
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Collagen-Supplemented Incubation Rapidly Augments Mechanical Property of Fibroblast Cell Sheets: Tissue Engineering Part A, Ahead of Print.AbstractCell sheet technology using UpCell™ (Thermo Fisher Scientific, Roskilde, Denmark) plates is a modern tool that enables the rapid creation of single-layered cells without using extracellular matrix (ECM) enzymatic digestion. Although this technique has the advantage of maintaining a sheet of cells without needing artificial scaffolds, these cell sheets...
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The effect of vitamin D supplementation on survival in patients with colorectal cancer: systematic review and meta-analysis of randomised controlled trials: British Journal of Cancer, Published online: 15 September 2020; doi:10.1038/s41416-020-01060-8The effect of vitamin D supplementation on survival in patients with colorectal cancer: systematic review and meta-analysis of randomised controlled trials AbstractBackgroundLow circulating vitamin D levels are associated with poor colorectal cancer...
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Cytotoxic CD8<sup>+</sup> T cells in cancer and cancer immunotherapy: British Journal of Cancer, Published online: 15 September 2020; doi:10.1038/s41416-020-01048-4Cytotoxic CD8+ T cells in cancer and cancer immunotherapy AbstractThe functions of, and interactions between, the innate and adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of...
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Autophagy as a therapeutic target in pancreatic cancer: British Journal of Cancer, Published online: 15 September 2020; doi:10.1038/s41416-020-01039-5 Autophagy as a therapeutic target in pancreatic cancer Pancreatic ductal adenocarcinoma (PDAC) is characterised by early metastasis and resistance to anti-cancer therapy, leading to an overall poor prognosis. Despite continued research efforts, no targeted therapy has yet shown meaningful efficacy in PDAC; mutations in the oncogene KRAS and the tumour...
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Can Straw Phonation Be Considered As Vocal Warm Up Among Speech Language Pathologists?: Can Straw Phonation Be Considered As Vocal Warm Up Among Speech Language Pathologists?J Voice. 2020 Sep 09;:Authors: Manjunatha U, Nayak PS, Bhat JSAbstract OBJECTIVE: Straw phonation exercises have been proved to be effective in improving voice quality among persons with voice pathology. The aim of the study was to investigate the effects of straw phonation as a warm-up exercise on maximum phonation...
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Extraarticular extrasynovial solitary osteochondromatosis of the ankle: A rare case report and review of literature.: Extraarticular extrasynovial solitary osteochondromatosis of the ankle: A rare case report and review of literature.Int J Surg Case Rep. 2020 Aug 31;75:61-65Authors: Thangavel M, Sivaram R, Jan W, Tariq A, Shanmugasundaram SAbstract INTRODUCTION: Synovial chondromatosis (SC) is a relatively common benign condition of the synovial joint characterized by the formation of cartilaginous...
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Neural Correlates of Sleep Recovery following Melatonin Treatment for Pediatric Concussion: A Randomized Controlled Trial: Journal of Neurotrauma, Ahead of Print.Evidence-based treatments for children with persistent post-concussion symptoms (PPCS) are few and limited. Common PPCS complaints such as sleep disturbance and fatigue could be ameliorated via the supplementation of melatonin, which has significant neuroprotective and anti-inflammatory properties. This study aims to identify neural correlates...
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Subjects with temporomandibular joint disc displacement and body posture assessment via rasterstereography: a pilot case-control study: OBJECTIVE: The possible relationship between temporomandibular disorders (TMDs) and body posture is still controversial. Rasterstereography has been introduced as a radiation-free, reliable and non-invasive method to analyze three-dimensional spinal posture. The aim of this case-control study is to evaluate, through rasterstereography, body posture parameters in...
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The phosphoinositide 3-kinase inhibitor alpelisib restores actin organization and improves proximal tubule dysfunction in vitro and in a mouse model of Lowe syndrome and Dent disease.: The phosphoinositide 3-kinase inhibitor alpelisib restores actin organization and improves proximal tubule dysfunction in vitro and in a mouse model of Lowe syndrome and Dent disease.Kidney Int. 2020 Sep 05;:Authors: Berquez M, Gadsby JR, Festa BP, Butler R, Jackson SP, Berno V, Luciani A, Devuyst O, Gallop JLAbstract...
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Uncaria tomentosa reduces osteoclastic bone loss in vivo.: Uncaria tomentosa reduces osteoclastic bone loss in vivo.Phytomedicine. 2020 Sep 02;79:153327Authors: Lima V, Melo IM, Taira TM, Buitrago LYW, Fonteles CSR, Leal LKAM, Souza ASQ, Almeida TS, Costa Filho RND, Moraes MO, Cunha FQ, Fukada SYAbstract BACKGROUND: The genus Uncaria (Rubiaceae) has several biological properties significant to human health. However, the mechanisms underlying the protective effect of this plant on bone diseases...
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Intestinal resection affects whole-body arginine synthesis in neonatal piglets.: Intestinal resection affects whole-body arginine synthesis in neonatal piglets.Pediatr Res. 2020 Sep 13;:Authors: Lansing M, Slim G, Wizzard P, Rafii M, Pencharz PB, Nation PN, Beggs MR, Todd Alexander R, Wales PW, Turner JM, Ball ROAbstract BACKGROUND: Previous studies in piglets show a direct relationship between intestinal mass and arginine (Arg) synthesis. We aimed to study the effects of 75% intestinal...
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Understanding the mechanisms of placebo and nocebo effects.: Understanding the mechanisms of placebo and nocebo effects.Swiss Med Wkly. 2020 Aug 24;150:w20340Authors: Frisaldi E, Shaibani A, Benedetti FAbstract Although placebos have long been considered a nuisance in clinical research, over recent years they have become an active and productive field of research. Indeed, the placebo effect represents an elegant model to understand how the brain works. It is worth knowing that there is not...
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Prognostic Factors, Treatment, and Survival in Primary Cutaneous Mucinous Carcinoma: A SEER Database Analysis: BACKGROUND Limited information exists on the demographics, tumor characteristics, and treatment in primary cutaneous mucinous carcinoma (PCMC). OBJECTIVE The authors sought to describe prognostic factors, incidence rates, and the subsequent primary malignancy (SPM) risk in patients with PCMC. METHODS Primary cutaneous mucinous carcinoma cases in the National Cancer Institute's Surveillance,...
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Use of Autologous, Noncultured Melanocyte–Keratinocyte Transplantation in Patients With Stable Genital Leucoderma: No abstract available
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Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine.: (1) routine thromboprophylaxis with weight-adjusted intermediate doses of LMWH (unless contraindication); (2) LMWH as the drug of choice over unfractionated heparin or direct oral anticoagulants for the treatment of VTE or hypercoagulability; (3) careful evaluation of the risk for disease worsening and prompt...
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Strip Graft of the Eyebrow for the Treatment of Traumatic Madarosis of Upper and Lower Eyelid: No abstract available
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Robust Single-Stage Reconstruction of the Mid and Anterior Alar Rim: No abstract available
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Vulvar Lichen Sclerosus: Consider Treatment With Heterologous Type I Collagen: No abstract available
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Temporary Greater Auricular Nerve Paresthesia After Radiofrequency Microneedling Treatment: No abstract available
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Electron Microscopy of Argyria Treated With Picosecond Alexandrite Laser: No abstract available
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The Perialar Crescentic Advancement Flap: A Workhorse Flap for Small–Medium Size Defects of the Upper Cutaneous Lip: No abstract available
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Depth Map for Face and Neck Deep Chemical Peel Resurfacing: BACKGROUND Chemical peels are applied to the face and neck to improve rhytides and the photoaged appearance of the skin. Peels can be applied to different skin depths depending on the types of chemicals, the volume of solution, and the amount of pressure or friction applied. If a peel is applied too superficially, rhytides will not be removed. If a peel is applied too deeply, scarring or hypopigmentation could occur. OBJECTIVE To create...
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Catamenial Exacerbations of Cutaneous Neoplasms:
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High- Versus Low-Density Fractional Laser in the Treatment of Hypertrophic Postburn Scars: A Randomized Clinical Trial: BACKGROUND Fractional CO2 laser has been shown effective in improving pigmentation, pruritus, and tightness of hypertrophic burn scars. However, there is no consensus on the optimal treatment parameters. OBJECTIVE To compare effectiveness of different densities of fractional CO2 laser in the treatment of mature hypertrophic burn scars. MATERIALS AND METHODS The study included...
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Safety and Efficacy of Nanosecond Pulsed Electric Field Treatment of Seborrheic Keratoses: BACKGROUND Nanosecond pulsed electric field technology (also known as Nano-Pulse Stimulation or NPS) is a nonthermal, drug-free, energy-based technology that has demonstrated effects on cellular structures of the dermis and epidermis in previous clinical studies. OBJECTIVE To evaluate the safety and efficacy of a single NPS treatment for clearing seborrheic keratoses (SKs). MATERIALS AND METHODS This study...
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Use of Lasers for Iron-Induced Accidental Tattoos: Experience at a Tertiary Referral Center: BACKGROUND Awareness of accidental tattoos after iron injections with paravenous leakage is low. No larger patient cohorts have been analyzed. The lesions are a burden to the patients. The only known treatment is laser therapy. OBJECTIVE To characterize the clinical appearance and development of iron-induced tattoos and to demonstrate safe and efficient removal with quality-switched (QS) and picosecond...
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Effects of Hyaluronic Acid on Stability of Bleomycin Foam: BACKGROUND Bleomycin (BLM) foam sclerotherapy is effective in the treatment of venous malformations (VMs). Foam stability is influenced by factors such as sclerosant concentration, viscosity, and liquid–gas ratio. OBJECTIVE To investigate whether hyaluronic acid (HA) could increase the stability of BLM foam and to evaluate the safety and efficacy of HA—BLM foam. MATERIALS AND METHODS Experiment: BLM 6.0 IU + human serum albumin (HSA, 2,...
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The Force Required to Inject a Column of Filler Through Facial Arteries: BACKGROUND Injectable fillers have become an integral part of facial rejuvenation, but vascular occlusion is a dreaded complication of such injections. OBJECTIVE To determine the force required by the fingertip onto the plunger of the syringe to cause retrograde migration. METHODS In this cadaver study, twelve 2-cm arterial segments and 4 fillers were tested. Injection pressure required to force a column of filler for 1 cm...
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Reliability of Periocular Anthropometry: A Comparison of Direct, 2-Dimensional, and 3-Dimensional Techniques: BACKGROUND Three-dimensional (3D) imaging has become increasingly popular in aesthetic surgery. However, few studies have emphasized its application in the periocular region. OBJECTIVE To provide evidence supporting the reliability of generalizing periocular measurements obtained using caliper-derived direct anthropometry and 2-dimensional (2D) photogrammetry to 3D stereophotogrammetry....
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Soft Tissue Filler Properties Can Be Altered by a Small-Diameter Needle: BACKGROUND Small-bore needles reduce the complications associated with soft tissue filler injection. Gel particles must be sized appropriately to pass through fine-bore needles with an acceptable extrusion force. However, most soft tissue filler particles are larger than the inner diameter of the needle. The authors hypothesized that the physical properties of these particles change as the gel passes through the needle. OBJECTIVE...
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Validation of Photonumeric Assessment Scales for Temple Volume Deficit, Infraorbital Hollows, and Chin Retrusion: BACKGROUND Assessment scales are valuable tools in aesthetic clinical research and practice. OBJECTIVE To validate 3 photonumeric scales covering temple volume deficit, infraorbital hollows, and chin retrusion. MATERIALS AND METHODS Subjects reflecting the whole range of the scales were assessed independently by 3 evaluators at 2 separate occasions. Intraobserver agreement (the ability...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Telephone consultation 11855 int 1193,
