Background: In humans, many diseases are associated with the accumulation of free radicals. Antioxidants can scavenge free radicals and minimize their impact. Therefore, the search for naturally occurring antioxidants of plant origin is imperative. Here, we aimed to investigate the antioxidant and free radical scavenging properties of methanolic extracts from Tabebuia pallida (T. pallida) stem bark (TPSB), root bark (TPRB), leaves (TPL), and flowers (TPF). Methods: The antioxidant and free radical scavenging activity were determined by several standard methods using spectrophotomer. Total phenolic and flavonoid contents were estimated using Folin-Ciocalteu reagent and aluminum chloride colorimetric assay methods, respectively. Results: Among the extracts, TPL showed the highest total antioxidant capacity followed by TPRB, TPF, and TPSB. Based on DPPH and hydroxyl radical scavenging activity, TPL showed strong scavenging activity (91.05 ± 1.10 and 62.00 ± 0.57) with IC 50 of 9.20 ± 0.28 and 46.00 ± 2.84 μg/mL, respectively when compared with standard BHT (IC 50 of 7.00 ± 0.25 μg/mL) and CA (75.00 ± 0.14 μg/mL). These results suggest that TPL had the highest radical scavenging activity among the extractives that closely resembled the standard's. In lipid peroxidation inhibition assay, TPL exhibited the most potent inhibitory activity (83.18 ± 2.12 %) with IC 50 of 12.00 ± 2.12 μg/mL, which closely resembled standard CA (IC 50 of 10.50 ± 0.28 μg/mL). Also, the reducing capacity on ferrous ion was in the following order: TPL > TPRB > TF > TPSB. The phenolic and flavonoid contents of TPL were higher than other extractives. A positive correlation (p value <0.001) was observed between phenolic content and free radical (DPPH · and · OH) scavenging efficiencies and lipid peroxidation inhibition activity. Conclusion: Methanolic extract of T. pallida leaf is a potential source of natural antioxidants and serves as an effective free radical scavenger and/or inhibitor. Hence, T. pallida might be a good plant-based pharmaceutical product for several diseases caused by free radicals.
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Πέμπτη 29 Οκτωβρίου 2015
In vitro antioxidant and free radical scavenging activity of different parts of Tabebuia pallida growing in Bangladesh
Pollen loads of eucalypt and other pollen types in birds in NW Spain
Publication date: December 2015
Source:Data in Brief, Volume 5
Author(s): María Calviño-Cancela, Max Neumann
Here we present the amount of pollen of eucalypt and pollen of other types for birds captured in two bird ringing stations for 14 months (March 2014 to April 2015) in NW Spain. Common and latin names of all birds species captured, together with the number of captured individuals (N), prevalence of eucalypt pollen (percentage of individuals with eucalypt pollen) and of pollen of other types and average pollen loads per individual for eucalypt and other pollen types is presented. See [1] for further information and discussion.
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Rapid production of engineered human primary hepatocyte/fibroblast sheets
Publication date: December 2015
Source:Data in Brief, Volume 5
Author(s): Yusuke Sakai, Makiko Koike, Akihiko Soyama, Masaaki Hidaka, Tamotsu Kuroki, Susumu Eguchi
This data article contains data related to the research article entitled "Vascularized subcutaneous human liver tissue from engineered hepatocyte/fibroblast sheets in mice," published in Biomaterials[1]. Engineered hepatocyte/fibroblast sheets (EHFSs) are used for construction of vascularized subcutaneous liver tissue without a pre-transplant vascularization procedures. Here, we described a rapid production technique of EHFSs by controlling fibroblast density and coating fetal bovine serum (FBS) onto temperature-responsive culture dishes (TRCDs). The human fibroblast monolayer formed on FBS-coated TRCDs within 1h when seeded at a high density (at least 1.56×105cells/cm2). The most rapid EHFS production was achieved soon after the adhesion of human primary hepatocytes onto the fibroblast layer.
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Data on antioxidant activity in grapevine (Vitis vinifera L.) following cryopreservation by vitrification
Publication date: December 2015
Source:Data in Brief, Volume 5
Author(s): María Fernanda Lazo-Javalera, Martín Ernesto Tiznado-Hernández, Irasema Vargas-Arispuro, Elisa Valenzuela-Soto, María del Carmen Rocha-Granados, Marcos Edel Martínez-Montero, Marisela Rivera-Domínguez
Cryopreservation is used for the long-term conservation of plant genetic resources. This technique very often induces lethal injury or tissue damage. In this study, we measured indicators of viability and cell damage following cryopreservation and vitrification-cryopreservation in Vitis vinifera L. axillary buds cv. "Flame seedless" stored in liquid nitrogen (LN) for: three seconds, one hour, one day, one week and one month; after LN thawed at 38°C for three minutes. The enzymatic activity of catalase (CAT) and superoxide dismutase (SOD), as well as the amount of malondialdehyde (MDA), total protein and viability were assayed.
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Location of plant species in Norway gathered as a part of a survey vegetation mapping programme
Publication date: December 2015
Source:Data in Brief, Volume 5
Author(s): Anders Bryn, Hans-Petter Kristoffersen, Michael Angeloff, Ingvild Nystuen, Linda Aune-Lundberg, Dag Endresen, Christian Svindseth, Yngve Rekdal
Georeferenced species data have a wide range of applications and are increasingly used for e.g. distribution modelling and climate change studies. As an integrated part of an on-going survey programme for vegetation mapping, plant species have been recorded. The data described in this paper contains 18.521 registrations of plants from 1190 different circular plots throughout Norway. All species localities are georeferenced, the spatial uncertainty is provided, and additional ecological information is reported. The published data has been gathered from 1991 until 2015. The entries contain all higher vascular plants and pteridophytes, and some cryptogams. Other ecological information is also provided for the species locations, such as the vegetation type, the cover of the species and slope. The entire material is stored and available for download through the GBIF server.
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Data of a fluorescent imaging-based analysis of anti-cancer drug effects on three-dimensional cultures of breast cancer cells
Publication date: December 2015
Source:Data in Brief, Volume 5
Author(s): Junji Itou, Sunao Tanaka, Wenzhao Li, Yoshiaki Matsumoto, Fumiaki Sato, Masakazu Toi
Three-dimensional (3D) cell culture is a powerful tool to study cell growth under 3D condition. To perform a simple test for anti-cancer drugs in 3D culture, visualization of non-proliferated cells is required. We propose a fluorescent imaging-based assay to analyze cancer cell proliferation in 3D culture. We used a pulse-labeling technique with a photoconvertible fluorescent protein Kaede to identify non-proliferated cells. This assay allows us to observe change in cell proliferation in 3D culture by simple imaging. Using this assay, we obtained the data of the effects of anti-cancer drugs, 5-fluorouracil and PD0332991 in a breast cancer cell line, MCF-7.
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Data detailing the platelet acetyl-lysine proteome
Publication date: December 2015
Source:Data in Brief, Volume 5
Author(s): Joseph E. Aslan, Larry L. David, Owen J.T. McCarty
Here we detail proteomics data that describe the acetyl-lysine proteome of blood platelets (Aslan et al., 2015 [1]). An affinity purification – mass spectrometry (AP-MS) approach was used to identify proteins modified by Nε-lysine acetylation in quiescent, washed human platelets. The data provide insights into potential regulatory mechanisms of platelet function mediated by protein lysine acetylation. Additionally, as platelets are anucleate and lack histone proteins, they offer a unique and valuable system to study the regulation of cytosolic proteins by lysine acetylation. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium (Vizcaino et al., 2014 [2]) via with PRIDE partner repository with the dataset identifier PXD002332.
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Data supporting Arf6 regulation of Schwann cell differentiation and myelination
Publication date: December 2015
Source:Data in Brief, Volume 5
Author(s): Tomohiro Torii, Yuki Miyamoto, Masahiro Yamamoto, Katsuya Ohbuchi, Hideki Tsumura, Kazuko Kawahara, Akito Tanoue, Hiroyuki Sakagami, Junji Yamauchi
The data is related to the research article entitled "Arf6 mediates Schwann cell differentiation and myelination" [1]. To further investigate the role of Arf6 in promoting myelination by Schwann cells in vivo, we have characterized an another line (#2) of small-hairpin (sh)RNA transgenic mice targeting Arf6. The number of transgenes per one allele in this line was very low (2 transgenes), comparing with high copies in the previous line (#1, 20 transgenes) [1]. In 4 days of neonatal age, transgenic mice exhibited decreased myelin thickness; however, decreased levels were not as much as those in the line #1, likely depending on transgene copy number. In 60-day-old mice, the difference became smaller. On the other hand, transgene׳s effect was not related to cell proliferation and apoptosis. These data support the key role of Arf6 in Schwann cell myelination, especially in the initiation.
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Global proteomic characterization of microdissected estrogen receptor positive breast tumors
Publication date: December 2015
Source:Data in Brief, Volume 5
Author(s): Tommaso De Marchi, Ning Qing Liu, Christoph Sting, Marcel Smid, Mila Tjoa, René B.H. Braakman, Theo M. Luider, John A. Foekens, John W.M. Martens, Arzu Umar
We here describe two proteomic datasets deposited in ProteomeXchange via PRIDE partner repository [1] with dataset identifiers PXD000484 (defined as "training") and PXD000485 (defined as "test") that have been used for the development of a tamoxifen outcome predictive signature [2]. Both datasets comprised 56 fresh frozen estrogen receptor (ER) positive primary breast tumor specimens derived from patients who received tamoxifen as first line therapy for recurrent disease. Patient groups were defined based on time to progression (TTP) after start of tamoxifen therapy (6 months cutoff): 32 good and 24 poor treatment outcome patients were comprised in the training set, respectively. The test set included 41 good and 15 poor treatment outcome patients. All specimens were subjected to laser capture microdissection (LCM) to enrich for epithelial tumor cells prior to high resolution mass spectrometric (MS) analysis. Protein identification and label-free quantification (LFQ) were performed with MaxQuant software package [3]. A total of 3109 and 4061 proteins were identified and quantified in the training and test set, respectively. We here present the first public proteomic dataset analyzing ER positive recurrent breast cancer by LCM coupled to high resolution MS.
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Structure and fabrication details of an integrated modularized microfluidic system
Publication date: December 2015
Source:Data in Brief, Volume 5
Author(s): Qingchang Tian, Ying Mu, Yanan Xu, Qi Song, Bingwen Yu, Congcong Ma, Wei Jin, Qinhan Jin
This article contains schemes, original experimental data and figures for an integrated modularized microfluidic system described in "An integrated microfluidic system for bovine DNA purification and digital PCR detection [1]". In this data article, we described the structure and fabrication of the integrated modularized microfluidic system. This microfluidic system was applied to isolate DNA from ovine tissue lysate and detect the bovine DNA with digital PCR (dPCR). The DNA extraction efficiency of the microdevice was compared with the efficiency of benchtop protocol.
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Lectin staining and Western blot data showing differential sialylation of nutrient-deprived cancer cells to sialic acid supplementation
Publication date: December 2015
Source:Data in Brief, Volume 5
Author(s): Haitham A. Badr, Dina M.M. AlSadek, Mohit P. Mathew, Chen-Zhong Li, Leyla B. Djansugurova, Kevin J. Yarema, Hafiz Ahmed
This report provides data that are specifically related to the differential sialylation of nutrient deprived breast cancer cells to sialic acid supplementation in support of the research article entitled, "Nutrient-deprived cancer cells preferentially use sialic acid to maintain cell surface glycosylation" [1]. Particularly, breast cancer cells, when supplemented with sialic acid under nutrient deprivation, display sialylated glycans at the cell surface, but non-malignant mammary cells show sialylated glycans intracellularly. The impact of sialic acid supplementation under nutrient deprivation was demonstrated by measuring levels of expression and sialylation of two markers, EGFR1 and MUC1. This Data in Brief article complements the main manuscript by providing detailed instructions and representative results for cell-level imaging and Western blot analyses of changes in sialylation during nutrient deprivation and sialic acid supplementation. These methods can be readily generalized for the study of many types of glycosylation and various glycoprotein markers through the appropriate selection of fluorescently-labeled lectins.
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New Medical Articles,October 30th,2015
The first perforating branch of the deep femoral artery – a reliable recipient vessel for vascularized fibular grafts: An anatomical study
Although the perforating branches of the deep femoral artery have been introduced as recipient vessels for vascularized fibular grafts in the treatment of osteonecrosis of the femoral head, comprehensive knowledge of the related anatomy is deficient. The purposes of this study were to provide detailed anatomical data for the perforating branches of the deep femoral artery and validate their usefulness as recipient vessels for vascularized fibular grafts. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1WmIHU4 via IFTTT
2-Arylquinazolin-4(3H)-ones: A New Class of α-Glucosidase Inhibitors
Publication date: Available online 29 October 2015 *Source:*Bioorganic & Medicinal Chemistry Author(s): Kulsoom Javaid, Syed Muhammad Saad, Saima Rasheed, Syed Tarique Moin, Naima Syed, Itrat Fatima, Uzma Salar, Khalid Mohammed Khan, Shahnaz Perveen, M. Iqbal Choudhary Twenty-five derivatives of 2-arylquinazolin-4(3H)-ones (1-25) were evaluated for their yeast (Saccharomyces cerevisiae) α-glucosidase inhibitory activities. All synthetic compounds, except 1 and 6, were found to be several hundred fold more active (IC50 values in the range of 0.3 ± 0.01 - 117.9 ± 1.76 μM), than the st... περισσότερα »
In Vivo Evaluation of [11C]DASB for Quantitative SERT Imaging in Rats and Mice
Serotonin (5-HT) plays a key role in the central nervous system and is involved in many essential neurological processes, such as mood, social behavior and sleep. The serotonin transporter ligand [11C]DASB has been used to determine the binding potential (BPND), which is the ratio of available transporter sites (Bavail) and radioligand affinity (1/appKD) under in vivo conditions. Due to the increasing number of animal models of human diseases, there is a pressing need to evaluate the applicability of [ 11C]DASB to rats and mice. Here, we assessed the feasibility of using [11C]DASB ... περισσότερα »
Comparison of the therapeutic response to treatment with a 177-lutetium labeled somatostatin receptor agonist and antagonist in preclinical models
Peptide receptor scintigraphy (PRS) and peptide receptor radionuclide therapy (PRRT) using radiolabeled somatostatin receptor (SSTR) agonists are successfully being applied in the clinic for imaging and treatment of neuroendocrine tumors. Contrary to the paradigm that internalization and the resulting accumulation of radiotracers in cells is necessary for efficient tumor targeting, recent studies have demonstrated superiority of radiolabeled SSTR antagonists for imaging purposes, despite little to no internalization in cells. However, studies comparing the therapeutic anti-tumor e... περισσότερα »
The positron emission tomographic radioligand 18F-FIMX images and quantifies metabotropic glutamate receptor 1 in proportion to the regional density of its gene transcript in human brain
A recent study from our laboratory found that 18F-FIMX is an excellent positron emission tomography (PET) radioligand for quantifying metabotropic glutamate receptor 1 (mGluR1) in monkey brain. This study evaluated the ability of 18F-FIMX to quantify mGluR1 in humans. A second goal was to use the relative density of mGluR1 gene transcripts in brain regions to estimate specific uptake (VS) and nondisplaceable uptake (VND) in each brain region. *Methods:* After injection of 189 ± 3 MBq of 18F-FIMX, 12 healthy volunteers underwent a dynamic PET scan over 120 minutes. In six of them, ... περισσότερα »
Can a Novel 18F-ALF-NOTA-PRGD2 PET/CT Predict the Treatment Sensitivity of Concurrent Chemoradiotherapy in Patients with Newly Diagnosed Glioblastoma?
*Purpose:* This study examined the value of a novel one-step labeled integrin αvβ3-targeting18F-AlF-NOTA-PRGD2 (denoted as 18F-RGD) in assessing the sensitivity of concurrent chemoradiotherapy (CCRT) in patients with newly diagnostic glioblastoma multiforme (GBM). *Methods:* 25 patients with newly diagnosed GBM were enrolled in this study 3-5 weeks after surgical resection. All participants were investigated with 18F-RGD PET/CT on baseline (T1) and the third week (T2) after the start of CCRT. Tumor volume (TV), maximal and mean standard uptake of the tumor (SUVmax, SUVmean) and tu...περισσότερα »
Radioimmunotherapy: from current clinical success to future industrial breakthrough?
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Evaluation of the outcome of lung nodules missed on 18F-FDG PET/MRI compared to 18F-FDG PET/CT in patients with known malignancies
The lower detection rate of 18F-fluordesoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) compared to 18F-FDG PET/computed tomography (18F-FDG PET/CT) regarding small lung nodules should be considered in the staging of malignant tumors. The purpose of this study was to evaluate the outcome of these small lung nodules missed by 18F-FDG PET/MRI. *Material and Methods:* Fifty-one oncologic patients (mean age: 56.6±14.0 years; 29 female, 22 male; tumor stages: I (*n* = 7), II (*n* = 7), III (*n* = 9), IV (*n* = 28)) who underwent 18F-FDG PET/CT and s... περισσότερα »
Radiolabeled Peptides for Imaging and Therapy: A Radiant Future
Radiolabeled peptides (radiopeptides) are very powerful tools for diagnostic imaging and radionuclide therapy of various diseases. Since the introduction of the first radiopeptide into the clinical setting to diagnose neuroendocrine tumors (NETs) about 25 years ago, many advances have been made in the field. This short review aims to highlight novel strategies to improve the application of radiopeptides for imaging and therapy. from #Medicine via ola Kala on Inoreader http://ift.tt/1GA7XVt via IFTTT
Inhibition of the Hemolytic Activity caused by Staphylococcus aureus alpha-Hemolysin through Isatin-Schiff Copper(II) Complexes
A great number of pathogens secrete pore-forming proteins during infection. Such molecules, from either bacterial or viral origin, are considered important virulence factors, which makes them attractive targets in the study of new therapeutic agents. Thus, the inhibitory activity of Isatin-Schiff base copper(II) complexes was evaluated against membrane damage activity of *Staphylococcus aureus* α-hemolysin (α-HL). For this purpose, a standard hemolysis assay with rabbit erythrocytes and micromolar concentrations of the compounds was employed. Additionally, planar artificial lipid ...περισσότερα »
An international comparison of the management of the neck in early oral squamous cell carcinoma in the Netherlands, UK, and USA
Early oral cavity squamous cell carcinoma (OCSCC) management appears to vary both within and between countries. Variation in practice can be an indicator of absence of evidence-based management and may negatively influence survival and morbidity. The exact variation and the relationship to differences in guidelines are unknown. This study aimed to report on these variations in the Netherlands, UK, and USA, and to evaluate them. from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1PXZ6yE via IFTTT
WEB Treatment of Intracranial Aneurysms: Clinical and Anatomic Results in the French Observatory [ADULT BRAIN]
BACKGROUND AND PURPOSE: Flow disruption with the WEB device is a new technique for the endovascular treatment of wide-neck bifurcation aneurysms. To obtain precise data regarding the safety and efficacy of this treatment with high-quality methodology, the prospective French Observatory study was conducted. Analysis of these data is presented, including 1-year follow-up. MATERIALS AND METHODS: Patients with bifurcation aneurysms for which WEB treatment was indicated were included in this prospective, multicenter Good Clinical Practice study. Clinical data, including adverse event...περισσότερα »
The Role of Wnt Signaling in Squamous Cell Carcinoma
Aberrant Wnt signaling pathway is a common feature of tumors and also plays important roles in tumor progression and metastasis of many cancer types. Various lines of evidence suggest that genetic defects affect Wnt pathway components, as well as epigenetic mechanisms that modulate the suppressors of Wnt pathway in oral squamous cell carcinoma. Recently, the newly discovered microRNAs are important molecular regulators in gene expression through transcription and translation repression. They play fundamental roles in a wide spectrum of biological functions, including cancer. In thi...περισσότερα »
Immuno-PET imaging of CD30 positive lymphoma using 89Zr-DFO-AC-10
The CD30-specific antibody-drug conjugate, brentuximab vedotin (BV), is approved for the treatment of relapsed, refractory Hodgkin lymphomas, and systemic anaplastic large T-cell lymphomas. Multiple ongoing clinical trials investigate BV efficacy in other CD30 positive hematologic malignancies. Since CD30 expression varies among different types of lymphoma, and can also change during the course of treatment, companion diagnostic imaging of CD30 could be a valuable tool in optimizing patient-specific BV treatment regimens. *Methods:* The mouse anti-human CD30 antibody AC-10 was rad... περισσότερα »
An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis [ARTICLE]
*N**6*-threonylcarbamoyladenosine (t6A) is one of the few RNA modifications that is universally present in life. This modification occurs at high frequency at position 37 of most tRNAs that decode ANN codons, and stabilizes cognate anticodon–codon interactions. Nearly all genetic studies of the t6A pathway have focused on single-celled organisms. In this study, we report the isolation of an extensive allelic series in the *Drosophila* ortholog of the core t6A biosynthesis factor Kae1. *kae1* hemizygous larvae exhibit decreases in t6A that correlate with allele strength; however, we... περισσότερα »
The Role of Wnt Signaling in Squamous Cell Carcinoma
Aberrant Wnt signaling pathway is a common feature of tumors and also plays important roles in tumor progression and metastasis of many cancer types. Various lines of evidence suggest that genetic defects affect Wnt pathway components, as well as epigenetic mechanisms that modulate the suppressors of Wnt pathway in oral squamous cell carcinoma. Recently, the newly discovered microRNAs are important molecular regulators in gene expression through transcription and translation repression. They play fundamental roles in a wide spectrum of biological functions, including cancer. In thi...περισσότερα »
Iatrogenic pressure sores: primum non nocere
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Three orphans one should know: red scalp, red ear and red scrotum syndrome
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Penile ‘tuberculid’: could it be sexually acquired primary inoculation tuberculosis?
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Apoptosis in chronic tonsillitis and tonsillar hypertrophy.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Apoptosis in chronic tonsillitis and tonsillar hypertrophy.* Int J Pediatr Otorhinolaryngol. 2015 Feb;79(2):191-5 Authors: Önal M, Yılmaz T, Bilgiç E, Müftüoğlu SF, Kuşçu O, Günaydın RÖ Abstract OBJECTIVE: Chronic tonsillitis is the persistent inflammation of the tonsillar tissue that occurs due to recurrent, acute or subclinical infection. The recurrent and chronic inflammation of palatine tonsils sometimes results in hypertrophy. Apoptosis provides an important balance between lymphocytes in tonsillar lymphoid t... περισσότερα »
The Verifit Directional Mic Test: Evaluating Modern Directional Microphone Technologies
Directional microphone technology has been available for nearly fifty years, and remains even to this day, the single most effective approach to improving signal-to-noise ratio (SNR) for certain listening conditions within a "head-worn" hearing instrument device (Lybarger & Lybarger, 2000). Why is improving SNR important? Because even modest improvements can have a significant impact on speech intelligibility, particularly in less reverberant environments. As Harvey Dillon (2006) has illustrated, a 1 dB improvement in SNR can have as much as an 18% improvement in speech intelligib...περισσότερα »
Properties of short double-stranded RNAs carrying randomized base pairs: toward better controls for RNAi experiments [METHOD]
Short interfering RNAs (siRNAs) are mediators of RNA interference (RNAi), a commonly used technique for selective down-regulation of target gene expression. Using an equimolar mixture of A, G, C, and U phosphoramidites during solid-phase synthesis, we introduced degenerate positions into RNA guide and passenger strands so that, when annealed, a large pool of distinct siRNA duplexes with randomized base pairs at defined sites was created. We assessed the randomization efficiency by deep sequencing one of the RNAs. All possible individual sequences were present in the pool with gene...περισσότερα »
Incidence of ventilator-associated pneumonia in Australasian intensive care units: use of a consensus-developed clinical surveillance checklist in a multisite prospective audit
Objectives With disagreements on diagnostic criteria for ventilator-associated pneumonia (VAP) hampering efforts to monitor incidence and implement preventative strategies, the study objectives were to develop a checklist for clinical surveillance of VAP, and conduct an audit in Australian/New Zealand intensive care units (ICUs) using the checklist. Setting Online survey software was used for checklist development. The prospective audit using the checklist was conducted in 10 ICUs in Australia and New Zealand. Participants Checklist development was conducted with members of a ... περισσότερα »
Design of the DRAGET Study: a multicentre controlled diagnostic study to assess the detection of acute rejection in patients with heart transplant by means of T2 quantification with MRI in comparison to myocardial biopsies
Introduction Patients with heart transplant are screened for silent graft rejection by recurrent endomyocardial biopsies. MRI can detect the presence of oedema non-invasively by quantitatively measuring changes of the transverse relaxation time T2 in the myocardium. Several monocentric studies have shown that T2 quantification could help detect graft rejection in a less invasive way. DRAGET is a national multicentre diagnostic study designed to prove that T2 quantification by MRI can detect graft rejection. Methods and analysis 190 patients from 10 centres will undergo T2 quanti... περισσότερα »
Non-dental primary care providers' views on challenges in providing oral health services and strategies to improve oral health in Australian rural and remote communities: a qualitative study
Objectives To investigate the challenges of providing oral health advice/treatment as experienced by non-dental primary care providers in rural and remote areas with no resident dentist, and their views on ways in which oral health and oral health services could be improved for their communities. Design Qualitative study with semistructured interviews and thematic analysis. Setting Four remote communities in outback Queensland, Australia. Participants 35 primary care providers who had experience in providing oral health advice to patients and four dental care providers who had... περισσότερα »
Association of rule of law and health outcomes: an ecological study
Objectives To explore whether the rule of law is a foundational determinant of health that underlies other socioeconomic, political and cultural factors that have been associated with health outcomes. Setting Global project. Participants Data set of 96 countries, comprising 91% of the global population. Primary and secondary outcome measures The following health indicators, infant mortality rate, maternal mortality rate, life expectancy, and cardiovascular disease and diabetes mortality rate, were included to explore their association with the rule of law. We used a novel Rul... περισσότερα »
Obstetrician and Gynecologist Utilization of the Noninvasive Prenatal Testing Expanded Option
AJP Rep DOI: 10.1055/s-0035-1566313 Objective Noninvasive prenatal testing (NIPT) enables the detection of common fetal aneuploidies such as trisomy 21, trisomy 18, trisomy 13, and sex chromosome abnormalities via analysis of cell-free fetal DNA circulating in maternal serum. In October 2013, the option to screen for additional trisomies and select microdeletion syndromes became clinically available. The complex testing methods, oftentimes unclear clinical utility of results, and lack of professional guidelines renders it challenging for clinicians to keep abreast of evolving pren... περισσότερα »
Do intravascular hypo- and hypervolaemia result in changes in central blood volumes?
Background Hypovolaemia is generally believed to induce centralization of blood volume. Therefore, we evaluated whether induced hypo- and hypervolaemia result in changes in central blood volumes (pulmonary blood volume (PBV), intrathoracic blood volume (ITBV)) and we explored the effects on the distribution between these central blood volumes and circulating blood volume (Vd circ). Methods Six anaesthetized, spontaneously breathing Foxhound dogs underwent random blood volume alterations in steps of 150 ml (mild) to 450 ml (moderate), either by haemorrhage, retransfusion of bloo...περισσότερα »
Disagreement between cardiac output measurement devices: which device is the gold standard?
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Saccharin Taste Conditions Flavor Preference in Weanling Rats
Innate and learned taste/flavor preferences to chemical stimuli in weanling rats are not fully understood. Our previous study showed that weanling rats could establish conditioned flavor preferences when low, but not high, concentrations of sucrose solutions were used as associative rewarding stimuli. Here, we examined whether 3-week-old rats could acquire flavor learning when the rewarding stimulus was saccharin, a non-nutritive artificial sweetener. In the acquisition session, they consumed water with a flavor (cherry or grape) and 0.1% sodium saccharin with another flavor (grap... περισσότερα »
Rates of pneumonia among children and adults with chronic medical conditions in Germany
Background: The objective of this study is to evaluate rates of all-cause pneumonia among "at-risk" and "high-risk" children and adults in Germany—in comparison with age-stratified healthy counterparts—during the period following the 2006 recommendation for universal immunization of infants with pneumococcal conjugate vaccine. Methods: Retrospective cohort design and healthcare claims information for 3.4 M persons in Germany (2009–2012) were employed. Study population was stratified by age and risk profile (healthy, "at-risk" [with chronic medical conditions], and "high-risk" [imm... περισσότερα »
4 Major Techniques of Malaria Prevention
[image: Simple Methods of Malaria Prevention] Malaria one of the most dangerous disease that has taken countless lives specifically in Asia & Africa where it exists in vast amount. Malaria is most probably caused due to transmission of parasite through bite from infected female Anopheles species of mosquitoes. Virus initially places itself within infected persons liver or bloodstream where it tends to multiply. Disease is quiet unique as it spreads between mosquitoes as well through bite of infected person causing them to remain infected throughout their life span. Malaria in oth... περισσότερα »
Human papillomavirus mediated inhibition of DNA damage sensing and repair drives skin carcinogenesis
Abstract Background The failure to mount an effective DNA damage response to repair UV induced cyclobutane pyrimidine dimers (CPDs) results in an increased propensity to develop cutaneous squamous cell carcinoma (cSCC). High-risk patient groups, such as organ transplant recipients (OTRs) frequently exhibit field cancerization at UV exposed body sites from which multiple human papillomavirus (HPV)-associated cSCCs develop rapidly, leading to profound morbidity and increased mortality. In vitro molecular evidence indicates that HPV of genus beta-papillomavirus (β-PV) play an importan...περισσότερα »
Study Identifies New Opportunities for Targeted Immunotherapy
A team of NCI researchers has reported that several types of gastrointestinal cancers have tumor-specific mutations that can be recognized by the immune system, potentially offering a new therapeutic opportunity for patients with these tumors. In the study, published October 29 in *Science*, researchers showed that T lymphocytes (cell-killing white blood cells) targeting tumor-specific genetic mutations can be identified in metastatic gastrointestinal tumors, according to the study's senior author, Steve Rosenberg, M.D., chief of the Surgery Branch in NCI's Center for Cancer Resea... περισσότερα »
Funding Opportunity: Genomic Data Analysis Network Centers
The National Cancer Institute (NCI) has published three companion Funding Opportunity Announcements (FOAs) for Genomic Data Analysis Network Centers to support programs of the Center for Cancer Genomics (CCG). The FOAs are managed by CCG and solicit applications for a Processing Genomic Data Center, a Visualization Genomic Data Center and a Specialized Genomic Data Center. The collective goal of these centers is to enable the cancer research community to develop tools and strategies to analyze the data generated from large-scale genomics projects and support the scientific communi... περισσότερα »
Interleukin-4 receptor-targeted liposomal doxorubicin as a model for enhancing cellular uptake and antitumor efficacy in murine colorectal cancer
10.1080/15384047.2015.1095397<br>Chih-Yung Yang from Cancer via ola Kala on Inoreader http://ift.tt/1WmlaTp via IFTTT
CD151 promotes α3β1 integrin-dependent organization of carcinoma cell junctions and restrains collective cell invasion
10.1080/15384047.2015.1095396<br>Shannin C Zevian from Cancer via ola Kala on Inoreader http://ift.tt/1Wml9Pe via IFTTT
Superior ophthalmic vein thrombosis associated with severe facial trauma: a case report
IntroductionSuperior ophthalmic vein thrombosis is a rare entity, but is associated with significant morbidities. We describe a case in which superior ophthalmic vein thrombosis occurred shortly after severe facial trauma.Case presentationA 77-year-old Japanese man was transferred to our tertiary hospital after a motor vehicle accident. Le Fort III facial bone fractures and a minor cerebral contusion were detected. Follow-up computed tomography scans detected dilatation of his left superior ophthalmic vein on day 3 and thrombosis on day 12; however, no causative carotid cavernous ... περισσότερα »
Acromegaly presenting with low insulin-like growth factor-1 levels and diabetes: a case report
IntroductionAcromegaly is an endocrine disorder arising from excessive serum growth hormone levels in adulthood and is characterized by progressive somatic enlargement. Biochemical confirmation is achieved by demonstration of elevated baseline serum growth hormone levels which are not suppressed during an oral glucose tolerance test, and by increased levels of serum insulin-like growth factor-1. The serum insulin-like growth factor-1 level provides an assessment of integrated growth hormone secretion and is recommended for diagnosis, monitoring, and screening of acromegaly. We rep...περισσότερα »
Risk factors for child abuse: levels of knowledge and difficulties in family medicine. A mixed method study
Background: Family physicians (FPs) have a central role in the detection and management of child abuse. According to the literature, only 2–5 % of initial reports of child abuse come from the medical profession. Methods: The objective of this study was to assess levels of knowledge of risk factors for child abuse by Family Physicians (FPs) and the attention that the physicians pay to these risk factors. We conducted a mixed-method survey based on semi-structured interviews. 50 FPs practicing in the Somme County (northern France) were interviewed with closed and open questions. The... περισσότερα »
GM-CSF: a possible prognostic serum biomarker of vitiligo patients' considered for transplantation treatment with cultured autologous melanocytes: a pilot study
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1kftQyB via IFTTT
Leprosy as a multilayered biosocial phenomenon: the comparison of institutional responses and illness narratives of an endemic disease in Brazil and an imported disease in Portugal
Publication date: Available online 28 October 2015 *Source:*Clinics in Dermatology Author(s): Alice Cruz This paper questions the relation between human health and society from the case-study of leprosy. In order to discuss the cultural and social mediator factors of both the experience of leprosy and outcomes of medical practices, it examines the biomedical twist in the dialectic between citizenship and public good that aimed to turn leprosy into a disease like any other, with the advent of multidrug therapy during the 1980's. Such analysis is based on a multi-sited ethnography, de... περισσότερα »
Opportunity Cost of Surgical Management of Craniomaxillofacial Trauma
Cranial Maxillofac Trauma Reconstruction DOI: 10.1055/s-0035-1566160 The provision of trauma care is a financial burden, continually associated with low reimbursement, and shifts the economic burden to major trauma centers and providers. Meanwhile, the volume of craniomaxillofacial (CMF) trauma and the number of surgically managed facial fractures are unchanged. Past financial analyses of cost and reimbursement for facial trauma are limited to mandibular and midface injuries, consistently revealing low reimbursement. The incurred financial burden also coincides with the changing l...περισσότερα »
Intravitreal ranibizumab for severe ROP
Arámbulo O, Dib G, Iturralde J, Duran F, Brito M, Fortes Filho JB from #Medicine via ola Kala on Inoreader http://ift.tt/1P0Pp3h via IFTTT
AngioVac extraction of intra-atrial hepatoma masquerading as PICC-associated thrombus.
Related Articles *AngioVac extraction of intra-atrial hepatoma masquerading as PICC-associated thrombus.* Diagn Interv Radiol. 2015 Oct 28; Authors: Abboud S, Raparia K, Ubago JM, Resnick S Abstract Thrombus associated with peripherally inserted central catheterization is not uncommon. Treatment is typically conservative; however, more aggressive therapies can be considered in patients with tenuous medical condition. The authors present a patient with metastatic hepatocellular carcinoma masquerading as peripherally inserted central catheter-associated intra-atrial thrombus, subs... περισσότερα »
Changes in Olfactory Sensory Neuron Physiology and Olfactory Perceptual Learning After Odorant Exposure in Adult Mice
The adult olfactory system undergoes experience-dependent plasticity to adapt to the olfactory environment. This plasticity may be accompanied by perceptual changes, including improved olfactory discrimination. Here, we assessed experience-dependent changes in the perception of a homologous aldehyde pair by testing mice in a cross-habituation/dishabituation behavioral paradigm before and after a week-long ester-odorant exposure protocol. In a parallel experiment, we used optical neurophysiology to observe neurotransmitter release from olfactory sensory neuron (OSN) terminals in vi... περισσότερα »
Neuropathic pain in leprosy
Publication date: Available online 29 October 2015 *Source:*Clinics in Dermatology Author(s): Irina Raicher, Patrick Raymond Nicolas Andre Ghislain Stump, Rosemari Baccarelli, Lucia H.S.C. Marciano, Somei Ura, Marcos C.L. Virmond, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade Nerve impairment is a key clinical aspect of leprosy and may present the distribution of mononeuropathy or multiple nerve trunks, small cutaneous nerve fibers and free nerve endings. The clinical range of leprosy is determined by individual cell-mediated immune response to infection that also may play a ro...περισσότερα »
Mechanical cardiopulmonary resuscitation in in-hospital cardiac arrest: a systematic review
[image: image]With increasing rates of in-hospital cardiac arrest, improving resuscitation outcomes is essential. Mechanical chest compressors seem to be related to improved outcome in out-of hospital cardiac arrest; however, the literature on its use in in-hospital cardiac arrest is scarce. We used the Medline public database to systematically review patient outcomes considering mechanical cardiopulmonary resuscitation in in-hospital cardiac arrest. Fourteen studies were found, most cases (n=17), three cohort studies, a clinical pilot study and a registry study. The reported surviv... περισσότερα »
Understanding the prehospital physician controversy. Step 2: analysis of on-scene treatment by ambulance nurses and helicopter emergency medical service physicians
[image: image]Objective: In our previous study, we identified the similarities and differences in competencies of ambulance nurses and helicopter emergency medical service (HEMS) physicians in the Netherlands. This ensuing study aims to quantify the frequency with which the additional therapeutic competencies of the HEMS physician are utilized and to determine whether this is the main reason for usefulness as perceived by ambulance nurses and HEMS physicians. Materials and methods: A prospective observational study was carried out over a 2-month period, with one HEMS station coverin... περισσότερα »
Stethoscope versus point-of-care ultrasound in the differential diagnosis of dyspnea: a randomized trial
[image: image]We aimed to determine the accuracies of point-of-care ultrasound (PoCUS) and stethoscopes as part of the physical examinations of patients with dyspnea. Three emergency medicine specialists in each of two groups of ultrasound and stethoscope performers underwent didactic and hands-on training on PoCUS and stethoscope usage. All the patients enrolled were randomized to one of two predetermined PoCUS or stethoscope groups. The diagnostic performance of ultrasonography was higher than that of the stethoscope in the diagnoses of heart failure (90 vs. 86%, 1.00 vs. 0.89, an...περισσότερα »
First-pass intubation success rate during rapid sequence induction of prehospital anaesthesia by physicians versus paramedics
[image: image]Introduction: Endotracheal intubation is a frequently performed procedure for securing the airway in critically injured or ill patients. Performing prehospital intubation may be challenging and intubation skills vary. We reviewed the first-attempt tracheal intubation success rate in a Dutch prehospital setting. Patients and methods: We studied our database for all intubations performed by helicopter emergency medical services (HEMS) physicians, HEMS nurse and ambulance paramedics under HEMS supervision between January 2007 and July 2012. The primary outcome was success...περισσότερα »
Training paramedics in focussed echo in life support
[image: image]Objectives: The aim of this study was to determine whether paramedics can be trained to perform and interpret focussed Echo in Life Support (ELS) for the assessment of cardiac movement and the recognition of reversible causes of cardiac arrest. Methods: This study is a prospective observational pilot study. Data were collected during a 1-day course training 11 paramedics to perform ELS scans on healthy volunteers. The students were assessed on image acquisition skills and theoretical knowledge (including interpretation). Level 1 ultrasound-trained emergency medicine ph...περισσότερα »
The effect of the introduction of a regional major trauma network on triage decisions made by a physician-staffed helicopter emergency medical service
[image: image]Background: A major trauma network (MTN) has been in place in the East of England, with a single hospital operating as the major trauma centre (MTC). The primary aim of this retrospective cohort study was to determine whether triage destination decisions with regard to trauma patients made by a helicopter-based doctor–paramedic team are affected by the introduction of a regional trauma network. In addition, we will describe and discuss the logistics of transfer of injured patients attended by the service. Methods: This is a retrospective database review that was carrie... περισσότερα »
Knowledge of ‘trusted person’ and ‘advance directive’ in end-of-life situations in prehospital emergency medicine 10 years after Leonetti’s law publication
No abstract available from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1GNIeZq via IFTTT
Ketamine for procedural sedation by a doctor-paramedic prehospital care team: a 4-year description of practice
[image: image]Background: Ketamine is a widely used drug that, depending on the dose administered, may be used as an analgesic or as a sedative or anaesthetic agent. A number of features make it attractive for prehospital use. At Essex and Herts Air Ambulance Trust, as with other services and under the guidance of a standard operating procedure, ketamine is used for both procedural sedation and as an anaesthetic agent for rapid sequence intubation. Guidelines exist that define levels of sedation and detail minimum standards of monitoring and personnel required for each level. Method... περισσότερα »
A description of echocardiography in life support use during cardiac arrest in an Emergency Department before and after a training programme
[image: image]Objectives: To investigate echocardiography in life support (ELS) use in Emergency Department (ED) cardiac arrest patients before and after a training day. Methods: A prospective before and after cohort study. Data was collated over a 24-month period before and after an ELS training day from our ED ultrasound database [Registry of Emergency Based Ultrasound Scanning (REBUS)], ED electronic patient records and from stored digital ELS scans. Results: In the year before ELS training, eight of 187 cardiac arrest patients had ELS performed (4.3%). In the year after training,... περισσότερα »
Emergency department procedural sedation: the London experience
[image: image]Aim: The aim of this study was to develop a procedural sedation guideline and an audit tool to identify the medications chosen, the incidence of predefined adverse events and the factors associated with their occurrence. Methods: We performed a prospective observational study using a standardized proforma. We obtained data on patient demographics, the procedure performed, the drugs used and the dosages and predefined adverse events. Our target population was adult patients attending three urban UK teaching hospital Emergency Departments (EDs) over a 12-month period. We...περισσότερα »
A quantitative tool for measuring the quality of medical training in emergency medicine
[image: image]The most common method of assessing the quality of medical education is through a selection of qualitative assessments, usually as part of a programme evaluation. Common qualitative assessments include measurements of students' and teachers' participation, outcome measures such as assessment results, and qualitative assessments such as interviews and questionnaires of students and teachers. Programme evaluation can therefore be a process that is both laborious and subject to accusations of a lack of objectivity. As a result, the development of a quantitative tool that ...περισσότερα »
Use of sedation in children receiving computed tomography after head injuries
[image: image]Objective: The aim of this study was to determine the use of procedural sedation for head trauma-related computed tomography of the brain (CTB) in children and its association with age and Glasgow Coma Scale (GCS) scores. Patients and methods: A retrospective review was carried out of charts of children undergoing a CTB for head injury at a tertiary paediatric emergency department with an annual census of 82 000 over a 2-year period. Patients were identified through the database of an ongoing prospective study involving children with head injuries of all severity. We e...περισσότερα »
Management of brain-dead donors outside the intensive care unit: a necessary recourse
[image: image]No abstract available from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1kfhJBA via IFTTT
Goal-directed ultrasound in emergency medicine: evaluation of a specific training program using an ultrasonic stethoscope
[image: image]Objective: This observational study aimed to define the learning curve in goal-directed ultrasound (US) after a 2-day training course dedicated to novice emergency residents. Materials and methods: After completion of the training program, 180 patients requiring goal-directed US examination were examined by a resident and by an experienced investigator. The main endpoints were the diagnostic agreement between the two operators for 14 clinical questions, the duration of the examinations, the number of nonaddressed questions, and the final diagnosis. All criteria were an...περισσότερα »
Predictive factors for invasive cancer in surgical specimens following an initial diagnosis of ductal carcinoma in situ after stereotactic vacuum-assisted breast biopsy in microcalcification-only lesions.
Related Articles *Predictive factors for invasive cancer in surgical specimens following an initial diagnosis of ductal carcinoma in situ after stereotactic vacuum-assisted breast biopsy in microcalcification-only lesions.* Diagn Interv Radiol. 2015 Oct 21; Authors: Gümüş H, Mills P, Fish D, Gümüş M, Cox K, Devalia H, Jones S, Jones P, Sever AR Abstract PURPOSE: The aim of this study was to determine the incidence of invasive breast carcinoma in patients with preoperative diagnosis of ductal carcinoma in situ (DCIS) by stereotactic vacuum-assisted biopsy (SVAB) performed for mic...περισσότερα »
Inhibition of the VEGF/VEGFR pathway improves survival in advanced kidney cancer: a systematic review and meta-analysis.
[image: http:--http://ift.tt/20eyjT5] Related Articles *Inhibition of the VEGF/VEGFR pathway improves survival in advanced kidney cancer: a systematic review and meta-analysis.* Curr Drug Targets. 2015;16(2):164-70 Authors: Iacovelli R, Sternberg CN, Porta C, Verzoni E, de Braud F, Escudier B, Procopio G Abstract Despite the improvement in progression-free survival and response rates, none of the five anti- VEGF/VEGFR agents used for treatment of metastatic renal cell carcinoma (mRCC) reported a significant increase in patients' survival. This analysis aims to investigate their e...περισσότερα »
Modulation of host defense peptide-mediated human mast cell activation by LPS
Human β-defensin3 (hBD3) and the cathelicidin LL-37 are host defense peptides (HDPs) that directly kill microbes and display immunomodulatory/wound-healing properties via the activation of chemokine, formylpeptide and epidermal growth factor receptors on leukocytes and epithelial cells. A C-terminal 14 amino acid hBD3 peptide with all Cys residues replaced with Ser (CHRG01) and an LL-37 peptide consisting of residues 17-29 (FK-13) display antimicrobial activity but lack immunomodulatory property. Surprisingly, we found that CHRG01 and FK-13 caused Ca2+ mobilization and degranulati...περισσότερα »
Innate immunity of surfactant proteins A and D in urinary tract infection with uropathogenic Escherichia coli
To investigate the effects of surfactant proteins A and D (SP-A and SP-D, respectively) in urinary tract infection (UTI), SP-A and SP-D double knockout (SP-A/D KO) and wild type (WT) C57BL/6 female mice were infected with uropathogenic *Escherichia coli* by intravesical inoculation. Compared with WT mice SP-A/D KO mice showed increased susceptibility to UTI, as evidenced by higher bacterial CFU, more infiltrating neutrophils and severe pathological changes. Keratinocyte-derived chemokine increased in the kidney of WT mice but not in SP-A/D KO mice 24 h post-infection. Compared wit...περισσότερα »
Impact of registration on clinical trials on infection risk in pediatric acute myeloid leukemia
Abstract Little is known about the impact of enrollment on therapeutic clinical trials on adverse event rates. Primary objective was to describe the impact of clinical trial registration on sterile site microbiologically documented infection for children with newly diagnosed acute myeloid leukemia (AML). We conducted a multi-center cohort study that included children aged ≤ 18 years with *de novo* AML. Primary outcome was microbiologically documented sterile site infection. Infection rates were compared between those registered and not registered on clinical trials. Five hundred se... περισσότερα »
Tumor-Associated Endothelial Cells Promote Tumor Metastasis by Chaperoning Circulating Tumor Cells and Protecting Them from Anoikis
by Arti Yadav, Bhavna Kumar, Jun-Ge Yu, Matthew Old, Theodoros N. Teknos, Pawan Kumar Tumor metastasis is a highly inefficient biological process as millions of tumor cells are released in circulation each day and only a few of them are able to successfully form distal metastatic nodules. This could be due to the fact that most of the epithelial origin cancer cells are anchorage-dependent and undergo rapid anoikis in harsh circulating conditions. A number of studies have shown that in addition to tumor cells, activated endothelial cells are also released into the blood circulation ... περισσότερα »
Birch pollen influences course of atopic eczema
Fölster-Holst R, Galecka J, Weißmantel S, Dickschat U, Rippke F, Bohnsack K, Werfel T, Wichmann K, Buchner M, Schwarz T, Vogt A, Lademann J, Meinke MC from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1PXH9QP via IFTTT
Clindamycin/BP 3.75% for acne
Nguyen TA, Eichenfield LF from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/20ehnfv via IFTTT
Emergency Medicine training and working conditions in Europe: a joint EuSEM young doctors – European Junior Doctors Survey
[image: image]No abstract available from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1kfhI0B via IFTTT
Tomographic Evaluation of Mandibular Thickness on Premolar and Molar Regions Related to Monocortical Screws
Cranial Maxillofac Trauma Reconstruction DOI: 10.1055/s-0035-1566162 The aim of this study was to measure the thickness of the mandible from the external cortical plate to the teeth roots on premolar and molar regions using CT scan to determine the safety margin for the application of monocortical screws for internal rigid fixation. Thirty-one patients underwent CT-scan imaging for surgical planning. The images were used to measure bilaterally the distance from the external cortex of the mandible to the roots of teeth on premolar and molar region by means of Dental Slice software ...περισσότερα »
Imaging of neuroinflammation: TSPO and beyond
from #Imaging via alexandrossfakianakis on Inoreader http://ift.tt/1Hf5o5G via IFTTT
Low-cost Negative-pressure Wound Therapy Using Wall Vacuum: A 15 Dollars by Day Alternative
[image: image]Background: Negative-pressure wound therapy (NPWT) has been marketed for about 20 years and remains popular. The only real obstacle to NPWT is the cost; therefore, we designed an inexpensive NPWT connected to a wall vacuum. Here, we report the feasibility and safety of this product, which we call PROVACUUM (Z-Biotech, Saint-Avertin, France). Methods: As a first step, the constraints imposed on the manufacturer were equipment quality similar to that of commercial NPWT systems, with an average treatment cost of $15/d. Then, we conducted a prospective study of patients wi... περισσότερα »
The influence of metallic shell deformation on the contact mechanics of a ceramic-on-ceramic total hip arthroplasty
Total hip arthroplasty of ceramic-on-ceramic bearing combinations is increasingly used clinically. The majority of these implants are used with cementless fixation that a metal-backing shell is press-fitted into the pelvic bone. This usually results in the deformation of the metallic shell, which may also influence the ceramic liner deformation and consequently the contact mechanics between the liner and the femoral head under loading. The explicit dynamic finite element method was applied to model the implantation of a cementless ceramic-on-ceramic with a titanium shell and subse... περισσότερα »
Vitamin A dietary supplementation reduces the mortality of velogenic Newcastle disease significantly in cockerels
Summary This project was undertaken to find ways of reducing mortalities and economic losses due to velogenic Newcastle disease (VND) in areas where the disease is enzootic. Four groups of cockerels of 44 birds each were used for this experiment. The birds in groups 1 and 2 received no dietary vitamin A supplementation, whereas groups 3 and 4 received 300 iu and 600 iu of vitamin A per kilogram of commercial feed, respectively, from 1 week of age till the end of the experiment. At 6 weeks of age, the birds in groups 2, 3 and 4 were inoculated intraocularly with a VND virus (duck/N...περισσότερα »
Multiple perforator preserving SGAP flap for the reconstruction of sacral wounds
Abstract Background Many surgical methods have been used to repair sacral sores, including primary closure, skin grafting, local random, and muscle flaps. After the description of the gluteal perforator-based flap, the perforator-based fasciocutaneous flap became popular in lumbosacral tissue defect reconstruction. Methods Multiple perforatory preserving superior gluteal artery perforator (SGAP) flap was performed in eight patients with lumbosacral soft tissue defects from May 2014 to April 2015. Five men and three women received the operation. The causes of defects were pilonida... περισσότερα »
Insulin is an important risk factor of endometrial cancer among premenopausal women: a case-control study in China
Abstract The aim of the article was to evaluate the important role played by insulin in the development of endometrial cancer (EC) among Chinese premenopausal women. In this study, 128 endometrial cancer patients and 294 controls who were all premenopausal were included. Baseline characteristics data were collected and serum insulin, C-peptide, sex hormone-binding globulin, C-reaction protein, interleukin-6, and tumor necrosis factor-α levels were measured. Paired *t* test, χ2 test, Spearman correlation coefficients, and univariate and multivariate logistic regression models were u... περισσότερα »
Revealing Hearing Loss: A Survey of How People Verbally Disclose Their Hearing Loss.
Objective: Hearing loss is the most common sensory deficit and congenital anomaly, yet the decision-making processes involved in disclosing hearing loss have been little studied. To address this issue, we have explored the phrases that adults with hearing loss use to disclose their hearing loss. Design: Since self-disclosure research has not focused on hearing loss-specific issues, we created a 15-question survey about verbally disclosing hearing loss. English speaking adults (>18 years old) with hearing loss of any etiology were recruited from otology clinics in a major referral ho... περισσότερα »
Research as a Standard of Care in PICU.
Objectives: Excellence in clinical care coupled with basic and applied research reflects the maturation of a medical subspecialty, advances that field, and provides objective data for identifying best practices. PICUs are uniquely suited for conducting translational and clinical research. In addition, multiple investigations have reported that a majority of parents are interested in their children's participation in clinical research, even when the research offers no direct benefit to their child. However, such activity may generate ethical conflict with bedside care providers trying... περισσότερα »
Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
[image: 53124fig1.jpg] Here, we present a protocol that examines specific steps of the viral entry to identify and evaluate novel antiviral agents. from #Medicine via ola Kala on Inoreader http://ift.tt/1Sci2sI via IFTTT
Influence of multiple factors on the incidence of occupational blood and body fluid exposures in health care workers in Guizhou, China: A structural equation modeling approach
Publication date: 1 November 2015 *Source:*American Journal of Infection Control, Volume 43, Issue 11 Author(s): Mingtao Quan, Lezhi Li, Xiaoli Yuan, Zhixia Jiang, Xuyao Wang, Hualian Wu, Xiaojuan Li BackgroundWe investigated the influence of multiple factors on the incidence of occupational blood and body fluid exposures (BBFEs) in health care workers (HCWs) in Guizhou, China, using structural equation modeling (SEM).MethodsSEM tested in general hospitals was evaluated using survey data from a sample of 1,774 HCWs from 25 hospitals in Guizhou, China, between January and April 2014....περισσότερα »
Editorial Board
Publication date: 1 November 2015 *Source:*American Journal of Infection Control, Volume 43, Issue 11 from Infection via ola Kala on Inoreader http://ift.tt/1Wkq9sX via IFTTT
APIC Masthead
Publication date: 1 November 2015 *Source:*American Journal of Infection Control, Volume 43, Issue 11 from Infection via ola Kala on Inoreader http://ift.tt/1Wkqa04 via IFTTT
Information for Readers
Publication date: 1 November 2015 *Source:*American Journal of Infection Control, Volume 43, Issue 11 from Infection via ola Kala on Inoreader http://ift.tt/1Wkq8oS via IFTTT
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Publication date: 1 November 2015 *Source:*American Journal of Infection Control, Volume 43, Issue 11 from Infection via ola Kala on Inoreader http://ift.tt/1M0abKz via IFTTT
APIC's Strategic Partner Program and Productive Collaborations
Publication date: 1 November 2015 *Source:*American Journal of Infection Control, Volume 43, Issue 11 from Infection via ola Kala on Inoreader http://ift.tt/1Wkq5JF via IFTTT
Table of Contents
Publication date: 1 November 2015 *Source:*American Journal of Infection Control, Volume 43, Issue 11 from Infection via ola Kala on Inoreader http://ift.tt/1M0a9lJ via IFTTT
Impact of Clostridium difficile-associated diarrhea on acute care length of stay, hospital costs, and readmission: A multicenter retrospective study of inpatients, 2009-2011
Publication date: 1 November 2015 *Source:*American Journal of Infection Control, Volume 43, Issue 11 Author(s): Glenn Magee, Marcie E. Strauss, Sheila M. Thomas, Harold Brown, Dorothy Baumer, Kelly C. Broderick BackgroundThe recent epidemiologic changes of Clostridium difficile-associated diarrhea (CDAD) have resulted in substantial economic burden to U.S. acute care hospitals. Past studies evaluating CDAD-attributable costs have been geographically and demographically limited. Here, we describe CDAD-attributable burden in inpatients, overall, and in vulnerable subpopulations from ...περισσότερα »
Social and political determinants of vaccine hesitancy: Lessons learned from the H1N1 pandemic of 2009-2010
Publication date: 1 November 2015 *Source:*American Journal of Infection Control, Volume 43, Issue 11 Author(s): Gustavo S. Mesch, Kent P. Schwirian BackgroundPublic acceptance of vaccination programs is essential for vaccine preventable diseases. However, increasing sectors of the population have expressed hesitancy about participating in such programs, leading to the re-emergence of vaccine preventable diseases. In this study we rely on a recreancy hypothesis to test the association between confidence in the government and local hospitals and the willingness to take the vaccine.Me...περισσότερα »
One Woman's Ability to Sniff Out Parkinson's Offers Hope to Sufferers
A musky odor may lead to new diagnostic tools for the neurodegenerative disease -- Read more on ScientificAmerican.com [image: the-senses?d=yIl2AUoC8zA] [image: the-senses?d=qj6IDK7rITs] [image: the-senses?d=l6gmwiTKsz0] [image: the-senses?i=65Bkpt7j9Wk:fJX56MaP7X8:gIN] [image: the-senses?d=QXVau8BzmBE] [image: the-senses?d=I9og5sOYxJI] [image: the-senses?d=ZC7T4KBF6Nw] from #ΓεύσηΌσφρηση via ola Kala on Inoreader http://ift.tt/1MlhGuC via IFTTT
Intervention Component Analysis (ICA): a pragmatic approach for identifying the critical features of complex interventions
Background: In order to enable replication of effective complex interventions, systematic reviews need to provide evidence about their critical features and clear procedural details for their implementation. Currently, few systematic reviews provide sufficient guidance of this sort. Methods: Through a worked example, this paper reports on a methodological approach, Intervention Component Analysis (ICA), specifically developed to bridge the gap between evidence of effectiveness and practical implementation of interventions. By (a) using an inductive approach to explore the nature o... περισσότερα »
Have a Fun (Yet Safe) Halloween
Tags: Mercy Top News Files: 20899.jpg 20899.jpg Media Contact: Nancy Corbett Halloween is known as a scary holiday, but usually not for the right reason. On average, twice as many child pedestrians are killed while walking on Halloween compared to other days of the year -- and only one-third of parents sit down with their kids to talk about the dangers the evening brings. With the occasion falling on a Saturday this year, it's expected that more kids will be out than usual. To keep your little goblins safe, be sure to follow these tips, provided by Safe Kids Worldwide. *Walk Sa... περισσότερα »
Conflicting results of robot-assisted versus usual gait training during postacute rehabilitation of stroke patients: a randomized clinical trial.
Robot gait training has the potential to increase the effectiveness of walking therapy. Clinical outcomes after robotic training are often not superior to conventional therapy. We evaluated the effectiveness of a robot training compared with a usual gait training physiotherapy during a standardized rehabilitation protocol in inpatient participants with poststroke hemiparesis. This was a randomized double-blind clinical trial in a postacute physical and rehabilitation medicine hospital. Twenty-eight patients, 39.3% women (72+/-6 years), with hemiparesis ( from #Medicine via ola Kala ... περισσότερα »
Ambient air pollution and risk of tuberculosis: a cohort study
Objectives Several respirable hazards, including smoking and indoor air pollution from biomass, were suggested to increase the risk of tuberculosis. Few studies have been conducted on ambient air pollution and tuberculosis. We investigated the association between exposure to ambient air pollution and incidence of active tuberculosis. Methods We conducted a cohort study using 106 678 participants of a community-based screening service in Taiwan, 2005–2012. We estimated individual exposure to air pollution using data from the nearest air quality monitoring station and the road in... περισσότερα »
Homeostatic 'bystander' proliferation of human peripheral blood B cells in response to polyclonal T-cell stimulation in vitro
The mechanisms of maintenance of adequate numbers of B lymphocytes and of protective levels of immunoglobulins in the absence of antigenic (re)stimulation remain not fully understood. Meanwhile, our results presented here show that both peripheral blood naive and memory B cells can be activated strongly and non-specifically (in a mitogen-like fashion) in 5-day *in vitro* cultures of anti-CD3- or concanavalin A (Con A)-stimulated peripheral blood mononuclear cells of healthy people. This polyclonal, bystander activation of the B cells includes multiple divisions of most of them (as... περισσότερα »
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Involvement of the cytoplasmic cysteine-238 of CD40 in its up-regulation of CD23 expression and its enhancement of TLR4-triggered responses
CD40, a member of the tumor necrosis factor receptor superfamily, plays a key role in both adaptive and innate immunity. Engagement of CD40 with its natural trimeric ligand or with cross-linked antibodies results in disulfide-linked CD40 (dl-CD40) homodimer formation, a process mediated by the cysteine-238 residues of the cytoplasmic tail of CD40. The present study was designed to elucidate the biological relevance of cysteine-238-mediated dl-CD40 homodimers to the expression of CD23 on B cells and to investigate its possible involvement in the innate response. Our results indicat... περισσότερα »
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Common marmoset CD117+ hematopoietic cells possess multipotency
Analysis of the hematopoiesis of non-human primates is important to clarify the evolution of primate-specific hematopoiesis and immune regulation. However, the engraftment and development of the primate hematopoietic system are well-documented only in humans and are not clear in non-human primates. *Callithrix jacchus* (common marmoset, CM) is a New World monkey with a high rate of pregnancy and small size that lives in closed colonies. As stem cell factor (SCF) is an essential molecule for hematopoietic stem cell development in mice and humans, we focused on CD117, the SCF recepto... περισσότερα »
Inflammatory response of endothelial cells to a human endogenous retrovirus associated with multiple sclerosis is mediated by TLR4
The MSRV (multiple sclerosis-associated retrovirus) belongs to the human endogenous retrovirus HERV-W family. The envelope protein originating from the MSRV has been found in most patients with multiple sclerosis (MS). This protein (Env-ms) has pro-inflammatory properties for several types of immune cells and could therefore play a role in MS pathogenesis by promoting the leukocyte diapedesis observed in the central nervous system of patients. Our study aims to analyze the effects of Env-ms on the blood–brain barrier (BBB) at a molecular and functional level. We demonstrate that t... περισσότερα »
Ostom-i Alert Keeps Track of Ostomy Pouch Volume
[image: Ostom-i-Alert][image: 11-Health]Having to use an ostomy bag is terrible business, so anything that can make the patient think less about the device is most welcome. *11 Health*, a company based near London, England, is releasing a device that keeps tabs on how full the ostomy pouch is, letting patients go about their business without having to manually check on the bag's status. The Ostom-i Alert is a sensor that measures how full the bag in, keeping track of how much it fills up every time there's discharge. It transmits readings to a paired smartphone app, letting the pa... περισσότερα »
Untangling the effects of tinnitus and hypersensitivity to sound (hyperacusis) in the gap detection test
Publication date: Available online 28 October 2015 *Source:*Hearing Research Author(s): R.H. Salloum, S. Sandridge, D.J. Patton, G. Stillitano, G. Dawson, J. Niforatos, L. Santiago, J.A. Kaltenbach In recent years, there has been increasing use of the gap detection reflex test to demonstrate induction of tinnitus in animals. Animals with tinnitus show weakened gap detection ability for background noise that matches the pitch of the tinnitus. The usual explanation is that the tinnitus 'fills in the gap'. It has recently been shown, however, that tinnitus is commonly associated with h... περισσότερα »
The Hidden Dysfunction of Otolithic Organs in Patients with Profound Sensorineural Hearing Loss
Publication date: Available online 28 October 2015 *Source:*Hearing Research Author(s): Xin-Da Xu, Chen-Ru Ding, Jing Yu, Zhao Han, Jun Gu, Na Gao, Xian-Hao Jia, Xu Luo, Jing Wang, Fang-Lu Chi ObjectiveTo define the profiles of ocular and cervical vestibular-evoked myogenic potentials (oVEMP and cVEMP, respectively) in patients with profound sensorineural hearing loss (PSHL).MethodsTwenty-nine patients with PSHL and 20 healthy volunteers were investigated. The patients' medical records were collected and analyzed. The ACS-evoked oVEMPs and cVEMPs and caloric test were tested and ana... περισσότερα »
The role of message strategy in improving hand hygiene compliance rates
Publication date: 1 November 2015 *Source:*American Journal of Infection Control, Volume 43, Issue 11 Author(s): Ronald E. Taylor BackgroundDespite increased attention to hand hygiene over the past decade compliance rates remain relatively low. Although there have been a number of improvements in the science of hand hygiene, very little attention has been devoted to the messages that promote it.MethodA total of 86 health care workers who are members of Association for Professionals in Infection Control and Epidemiology chapters participated in an online evaluation of 6 message strat...περισσότερα »
Conflicting results of robot-assisted versus usual gait training during postacute rehabilitation of stroke patients: a randomized clinical trial.
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 9 ώρες
Robot gait training has the potential to increase the effectiveness of walking therapy. Clinical outcomes after robotic training are often not superior to conventional therapy. We evaluated the effectiveness of a robot training compared with a usual gait training physiotherapy during a standardized rehabilitation protocol in inpatient participants with poststroke hemiparesis. This was a randomized double-blind clinical trial in a postacute physical and rehabilitation medicine hospital. Twenty-eight patients, 39.3% women (72+/-6 years), with hemiparesis ( from #Rehabilitation via ola... περισσότερα »
Warfarin resistance associated with genetic polymorphism of VKORC1: linking clinical response to molecular mechanism using computational modeling.
The variable response to warfarin treatment often has a genetic basis. A protein homology model of human vitamin K epoxide reductase, subunit 1 (VKORC1), was generated to elucidate the mechanism of warfarin resistance observed in a patient with the Val66Met mutation. The VKORC1 homology model comprises four transmembrane (TM) helical domains and a half helical lid domain. Cys132 and Cys135, located in the N-terminal end of TM-4, are linked through a disulfide bond. Two distinct binding sites for warfarin were identified. Site-1, which binds vitamin K epoxide (KO) in a catalytically ...περισσότερα »
Prolactin as an adjunct for type 1 diabetes immunotherapy
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FeedaMail: Microbiology via ola Kala on Inoreader
[image: feedamail.com] Microbiology via ola Kala on Inoreader (Sponsor this newsletter) Novel genetic markers define a subgroup of pathogenic Escherichia coli strains belonging to the B2 phylogenetic group The B2 phylogenetic group of *Escherichia coli* contains important pathogens such as extraintestinal pathogenic, adherent-invasive, and uropathogenic strains. In this study, we used comparative genomics and statistical methods to identify genetic variations that define a subset of pathogenic strains belonging to the B2 phylogenetic group. An initial proof of concept analysis ... περισσότερα »
Role of various DNA repair pathways in chromosomal inversion formation in CHO mutants
10.3109/09553002.2015.1101499<br>Ian M. Cartwright from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1LEQQ3i via IFTTT
Selective Fluorescence Detection of Cysteine over Homocysteine and Glutathione Based on a Cysteine-Triggered Dual Michael Addition/Retro-aza-aldol Cascade Reaction
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b03286 [image: ancham?d=yIl2AUoC8zA] from #Medicine via ola Kala on Inoreader http://ift.tt/1GNbGPd via IFTTT
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Publication date: October 2015 *Source:*The Kaohsiung Journal of Medical Sciences, Volume 31, Issue 10 from #Medicine via ola Kala on Inoreader http://ift.tt/1M057pj via IFTTT
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Publication date: October 2015 *Source:*The Kaohsiung Journal of Medical Sciences, Volume 31, Issue 10 from #Medicine via ola Kala on Inoreader http://ift.tt/1M059xr via IFTTT
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Publication date: October 2015 *Source:*The Kaohsiung Journal of Medical Sciences, Volume 31, Issue 10 from #Medicine via ola Kala on Inoreader http://ift.tt/1Wkj3EW via IFTTT
Comparison of patient and caregiver perception of pain from commonly performed accident and emergency services procedures.
Objective: To compare the perception by naive patients, emergency services clinicians and nurses, of healthcare-induced pain for procedures performed frequently by accident and emergency services. Methods: A prospective, three-part anonymous survey, given to caregivers and patients at arrival accident and emergency services. The primary endpoint was the a-priori estimated pain score for 10 procedures performed frequently by accident and emergency services. The same estimation was performed with the 'willingness-to-pay' method (amount allocated a priori to avoid this pain). Results: ...περισσότερα »
Duramycin-induced calcium release in cancer cells.
Duramycin, through binding with phosphatidylethanolamine (PE), has shown potential to be an effective antitumour agent. However, its mode of action in relation to tumour cells is not fully understood. PE expression on the surface of a panel of cancer cell lines was analysed using duramycin and subsequent antibody labelling, and then analysed by flow cytometry. Cell viability was also assessed by flow cytometry using annexin V and propidium iodide. Calcium ion (Ca2+) release by tumour cells in response to duramycin was determined by spectrofluorometry following incubation with Fluo-3,...περισσότερα »
Reduced SLC27A2 induces cisplatin resistance in lung cancer stem cells by negatively regulating Bmi1-ABCG2 signaling
Platinum-based chemotherapies have long been used as a standard treatment in non-small cell lung cancer (NSCLC). However, cisplatin resistance is a major problem that restricts the use of cisplatin. Lung cancer stem cells (LCSCs) represent a subpopulation that is responsible for chemo-resistance. We aim to investigate the biological function of SLC27A2 and its underlying mechanisms in regulating chemo-resistance to cisplatin in LCSCs. Here, our findings testified that CD166+ cells which were derived from fresh primary NSCLC samples displayed stem cell-like features and were resist... περισσότερα »
Sociodemographic Predictors of Breast Reconstruction Procedure Choice: Analysis of the Mastectomy Reconstruction Outcomes Consortium Study Cohort
Background. To promote patient-centered care, it is important to understand the impact of sociodemographic factors on procedure choice for women undergoing postmastectomy breast reconstruction. In this context, we analyzed the effects of these variables on the reconstructive method chosen. Methods. Women undergoing postmastectomy breast reconstruction were recruited for the prospective Mastectomy Reconstruction Outcomes Consortium Study. Procedure types were divided into tissue expander-implant/direct-to-implant and abdominally based flap reconstructions. Adjusted odds ratios were...περισσότερα »
Altered machinery of protein synthesis in Alzheimer's: from the nucleolus to the ribosome
Abstract Ribosomes and protein synthesis have been reported to be altered in the cerebral cortex at advanced stages of Alzheimer's disease (AD). Modifications in the hippocampus with disease progression have not been assessed. 67 cases including middle-aged (MA) and AD stages I-VI were analyzed. Nucleolar chaperones nucleolin, nucleophosmin and nucleoplasmin 3, and upstream binding transcription factor RNA polymerase I gene (*UBTF*) mRNAs are abnormally regulated and their protein levels reduced in AD. Histone modifications H3K9me2 and H3K12ac are decreased in CA1. Nuclear tau dec... περισσότερα »
Influence of geometry on swimming performance of helical swimmers using DoE
Abstract Helical microswimmers capable of propulsion at low Reynolds numbers have been proposed for numerous applications, ranging from in vitro tasks on lab-on-a-chip to in vivo applications for minimally invasive medicine. Several magnetically actuated helical swimmers with different geometry parameters have been proposed in prior works. However, the influence of the geometrical parameters on their swimming performance has not been clearly studied. In this paper, we propose a dimensionless study on the geometrical parameters using Design of Experiments (DoE), in order to find the...περισσότερα »
New Tool to Visualize Bile Ducts in Gallbladder Removal Surgeries (VIDEO)
[image: gallbladder-removal]Gallbladders are getting removed every day using laparoscopic tools, but every so often common bile ducts are accidentally damaged causing serious side effects, even resulting in liver failure or eventual liver transplant. While there are dyes and contrast agents available for an intraop cholangiography that can help visualize the relevant anatomy, they're rarely used because they complicate and extend the cholecystectomy procedures. At Hebrew University of Jerusalem researchers from the BioDesign: Medical Innovation program have been looking for a bet...περισσότερα »
Modulation of dendritic cell alternative activation and function by the vitamin A metabolite retinoic acid
The archetypal Th2 cytokine IL-4 has previously been shown to alternatively activate murine macrophages and, more recently, dendritic cells (DCs) both *in vitro* and *in vivo.* IL-4 has also been shown to induce *Aldh1a2* (aldehyde dehydrogenase 1a2) expression in murine macrophages recruited to the peritoneal cavity. However, the influence of IL-4 on DC *Aldh1a2* induction *in vivo* has not yet been addressed. In this work, we found that DCs show enhanced aldehyde dehydrogenase enzyme activity *in vivo*, which led us to investigate the impact of the vitamin A metabolite all-*trans...περισσότερα »
Modulation of genetic clusters for synthesis of bioactive molecules in fungal endophytes: A review
Publication date: Available online 29 October 2015 *Source:*Microbiological Research Author(s): V.B. Deepika, T.S. Murali, K. Satyamoorthy Novel drugs with unique and targeted mode of action are very much need of the hour to treat and manage severe multidrug infections and other life-threatening complications. Though natural molecules have proved to be effective and environmentally safe, the relative paucity of discovery of new drugs has forced us to lean towards synthetic chemistry for developing novel drug molecules. Plants and microbes are the major resources that we rely upon in... περισσότερα »
Immune defense is the primary function associated with the differentially expressed genes in the cochlea following acoustic trauma
Publication date: Available online 28 October 2015 *Source:*Hearing Research Author(s): Shuzhi Yang, Qunfeng Cai, R. Robert Vethanayagam, Jianmin Wang, Weiping Yang, Bo Hua Hu Our previous RNA-sequencing analysis of the rat cochlear genes identified multiple biological processes and molecular pathways in the cochlear response to acoustic overstimulation. However, the biological processes and molecular pathways that are common to other species have not been documented. The identification of these common stress processes is pivotal for a better understanding of the essential response ...περισσότερα »
Celecoxib prevents pressure overload-induced cardiac hypertrophy and dysfunction by inhibiting inflammation, apoptosis and oxidative stress
Abstract To explore the effects of celecoxib on pressure overload-induced cardiac hypertrophy (CH), cardiac dysfunction and explore the possible protective mechanisms. We surgically created abdominal aortic constrictions (AAC) in rats to induce CH. Rats with CH symptoms at 4 weeks after surgery were treated with celecoxib [2 mg/100 g body-weight(BW)] daily for either 2 or 4 weeks. Survival rate, blood pressure and cardiac function were evaluated after celecoxib treatment. Animals were killed, and cardiac tissue was examined for morphological changes, cardiomyocyte apoptosis, fibros... περισσότερα »
When Physics Takes Over: BAR Proteins and Membrane Curvature
Publication date: Available online 28 October 2015 *Source:*Trends in Cell Biology Author(s): Mijo Simunovic, Gregory A. Voth, Andrew Callan-Jones, Patricia Bassereau Cell membranes become highly curved during membrane trafficking, cytokinesis, infection, immune response, or cell motion. Bin/amphiphysin/Rvs (BAR) domain proteins with their intrinsically curved and anisotropic shape are involved in many of these processes, but with a large spectrum of modes of action. In vitro experiments and multiscale computer simulations have contributed in identifying a minimal set of physical p... περισσότερα »
Towards a Dynamic Understanding of Cadherin-Based Mechanobiology
Publication date: Available online 28 October 2015 *Source:*Trends in Cell Biology Author(s): Brenton D. Hoffman, Alpha S. Yap Cadherin-based cell–cell adhesions are a primary determinant of tissue structure. For several decades, it had been thought that the primary function of these ubiquitous structures was to resist external mechanical loads. Here we review recent evidence that cadherins also couple together the force-generating actomyosin cytoskeletons of neighbouring cells, serve as potent regulators of the actomyosin cytoskeleton, and activate diverse signalling pathways in re... περισσότερα »
IRAK1 mediates TLR4-induced ABCA1 downregulation and lipid accumulation in VSMCs
*IRAK1 mediates TLR4-induced ABCA1 downregulation and lipid accumulation in VSMCs* Cell Death and Disease 6, e1949 (October 2015). doi:10.1038/cddis.2015.212 Authors: L Guo, C-H Chen, L-L Zhang, X-J Cao, Q-L Ma, P Deng, G Zhu, C-Y Gao, B-H Li, Y Pi, Y Liu, Z-C Hu, L Zhang, Z-P Yu, Z Zhou & J-C Li from Cell via ola Kala on Inoreader http://ift.tt/1LZT2jS via IFTTT
Adding another piece to the retinoblastoma puzzle
*Adding another piece to the retinoblastoma puzzle* Cell Death and Disease 6, e1957 (October 2015). doi:10.1038/cddis.2015.317 Authors: M K E Blixt, S Shirazi Fard, C All-Ericsson & F Hallböök from Cell via ola Kala on Inoreader http://ift.tt/1LZSYRc via IFTTT
A conserved MADS-box phosphorylation motif regulates differentiation and mitochondrial function in skeletal, cardiac, and smooth muscle cells
*A conserved MADS-box phosphorylation motif regulates differentiation and mitochondrial function in skeletal, cardiac, and smooth muscle cells* Cell Death and Disease 6, e1944 (October 2015). doi:10.1038/cddis.2015.306 Authors: W Mughal, L Nguyen, S Pustylnik, S C da Silva Rosa, S Piotrowski, D Chapman, M Du, N S Alli, J Grigull, A J Halayko, M Aliani, M K Topham, R M Epand, G M Hatch, T J Pereira, S Kereliuk, J C McDermott, C Rampitsch, V W Dolinsky & J W Gordon from Cell via ola Kala on Inoreader http://ift.tt/1WjX5BV via IFTTT
Succinate dehydrogenase/complex II activity obligatorily links mitochondrial reserve respiratory capacity to cell survival in cardiac myocytes
*Succinate dehydrogenase/complex II activity obligatorily links mitochondrial reserve respiratory capacity to cell survival in cardiac myocytes* Cell Death and Disease 6, e1956 (October 2015). doi:10.1038/cddis.2015.310 Authors: R Dhingra & L A Kirshenbaum from Cell via ola Kala on Inoreader http://ift.tt/1LZSVF5 via IFTTT
P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest
*P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest* Cell Death and Disease 6, e1947 (October 2015). doi:10.1038/cddis.2015.268 Authors: A A Shamseddine, C J Clarke, B Carroll, M V Airola, S Mohammed, A Rella, L M Obeid & Y A Hannun from Cell via ola Kala on Inoreader http://ift.tt/1WjX4xI via IFTTT
DAB2IP loss confers the resistance of prostate cancer to androgen deprivation therapy through activating STAT3 and inhibiting apoptosis
*DAB2IP loss confers the resistance of prostate cancer to androgen deprivation therapy through activating STAT3 and inhibiting apoptosis* Cell Death and Disease 6, e1955 (October 2015). doi:10.1038/cddis.2015.289 Authors: J Zhou, Z Ning, B Wang, E-J Yun, T Zhang, R-C Pong, L Fazli, M Gleave, J Zeng, J Fan, X Wang, L Li, J-T Hsieh, D He & K Wu from Cell via ola Kala on Inoreader http://ift.tt/1KHVzO0 via IFTTT
Considering autophagy, β-Catenin and E-Cadherin as innovative therapy aspects in AML
*Considering autophagy, β-Catenin and E-Cadherin as innovative therapy aspects in AML* Cell Death and Disease 6, e1950 (October 2015). doi:10.1038/cddis.2015.314 Authors: K Kühn & W Römer from Cell via ola Kala on Inoreader http://ift.tt/1M3olhr via IFTTT
K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells
*K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells* Cell Death and Disease 6, e1954 (October 2015). doi:10.1038/cddis.2015.277 Authors: J R Yaron, S Gangaraju, M Y Rao, X Kong, L Zhang, F Su, Y Tian, H L Glenn & D R Meldrum from Cell via ola Kala on Inoreader http://ift.tt/1M3oocT via IFTTT
A novel miR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy
*A novel miR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy* Cell Death and Disease 6, e1948 (October 2015). doi:10.1038/cddis.2015.280 Authors: M d'Avenia, R Citro, M De Marco, A Veronese, A Rosati, R Visone, S Leptidis, L Philippen, G Vitale, A Cavallo, A Silverio, C Prota, P Gravina, A De Cola, E Carletti, G Coppola, S Gallo, G Provenza, E Bossone, F Piscione, M Hahne, L J De Windt, M C Turco & V De Laurenzi from Cell via ola Kala on Inoreader http://ift.tt/1M3onFR via IFTTT
miR-300 mediates Bmi1 function and regulates differentiation in primitive cardiac progenitors
*miR-300 mediates Bmi1 function and regulates differentiation in primitive cardiac progenitors* Cell Death and Disease 6, e1953 (October 2015). doi:10.1038/cddis.2015.255 Authors: F M Cruz, M Tomé, J A Bernal & A Bernad from Cell via ola Kala on Inoreader http://ift.tt/1KHVtG5 via IFTTT
Autophagy dysregulation by mutant fused in sarcoma—implications for amyotrophic lateral sclerosis
*Autophagy dysregulation by mutant fused in sarcoma—implications for amyotrophic lateral sclerosis* Cell Death and Disease 6, e1945 (October 2015). doi:10.1038/cddis.2015.311 Authors: K Y Soo & J D Atkin from Cell via ola Kala on Inoreader http://ift.tt/1M3oiSP via IFTTT
NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1
*NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1* Cell Death and Disease 6, e1943 (October 2015). doi:10.1038/cddis.2015.278 Authors: J Shi, G Fung, H Deng, J Zhang, F C Fiesel, W Springer, X Li & H Luo from Cell via ola Kala on Inoreader http://ift.tt/1M3ogtU via IFTTT
The correct renal function evaluation in patients with thyroid dysfunction
Abstract Thyroid dysfunction induces several renal derangements involving all nephron portions. Furthermore, dysthyroidism is a recognized risk factor associated with the development of chronic kidney disease. Current data, in fact, demonstrate that either subclinical or overt thyroid disease is associated with significant changes in creatinine, estimated glomerular filtration rate, measured glomerular filtration rate and Cystatin C. Herein, we systematically reviewed several relevant studies aiming at the identification of the most sensitive and specific parameter for the correct ... περισσότερα »
Importance of adult Dmbx1 in long-lasting orexigenic effect of agouti-related peptide
Endocrinology, Early Release. from Endocrinology via ola Kala on Inoreader http://ift.tt/1LW0UTz via IFTTT
Anandamide-induced endoplasmic reticulum stress and apoptosis are mediated by oxidative stress in non-melanoma skin cancer: Receptor-independent endocannabinoid signaling
Endocannabinoids are neuromodulatory lipids that regulate central and peripheral physiological functions. Endocannabinoids have emerged as effective antitumor drugs due to their ability to induce apoptosis in various cancer studies. The G-protein coupled cannabinoid receptors (CB1 and CB2) and the TRPV1 ion channel were reported to mediate the antiproliferative activity of endocannabinoids. However, receptor-independent effects also account for their activity. Our previous studies showed that the antiproliferative activity of anandamide (AEA) was regulated by cyclooxygenase-2 (CO... περισσότερα »
Doors Open at Humber River Hospital: North America’s First Digital Hospital
[image: Humbler-River-Hospital]Fifteen years of planning and millions of dollars later, Humber River Hospital in Toronto, Canada recently opened its doors as the first North American digital hospital, where robots are being used for a wide range of duties, and digital devices are facilitating communication between patients and healthcare professionals. The robots are automated to mix and administer chemotherapy drugs, and deliver meals and medical supplies to patients throughout the 1.8-million square feet of facility space, which includes calling an elevator and picking up and dr... περισσότερα »
Rectus Femoris Transfer Surgery Affects Balance Recovery in Children with Cerebral Palsy: A Computer Simulation Study
Publication date: Available online 28 October 2015 *Source:*Gait & Posture Author(s): Misagh B. Mansouri, Ashley E. Clark, Ajay Seth, Jeffrey A. Reinbolt Stiff-knee gait is a troublesome movement disorder among children with cerebral palsy (CP), where peak swing phase knee flexion is diminished due to over-activity of the rectus femoris muscle. A common treatment for stiff-knee gait, rectus femoris transfer surgery, moves the muscle's distal tendon from the patella to the sartorius insertion on the tibia. As a biarticular muscle, rectus femoris may play a role in motor control and ... περισσότερα »
Do characteristics of a stationary obstacle lead to adjustments in obstacle stepping strategies?
Publication date: Available online 28 October 2015 *Source:*Gait & Posture Author(s): Timothy A. Worden, Audrey F. De Jong, Lori Ann Vallis Navigating cluttered and complex environments increases the risk of falling. To decrease this risk, it is important to understand the influence of obstacle visual cues on stepping parameters, however the specific obstacle characteristics that have the greatest influence on avoidance strategies is still under debate. The purpose of the current work is to provide further insight on the relationship between obstacle appearance in the environment an... περισσότερα »
Untangling the effects of tinnitus and hypersensitivity to sound (hyperacusis) in the gap detection test
Publication date: Available online 28 October 2015 *Source:*Hearing Research Author(s): R.H. Salloum, S. Sandridge, D.J. Patton, G. Stillitano, G. Dawson, J. Niforatos, L. Santiago, J.A. Kaltenbach In recent years, there has been increasing use of the gap detection reflex test to demonstrate induction of tinnitus in animals. Animals with tinnitus show weakened gap detection ability for background noise that matches the pitch of the tinnitus. The usual explanation is that the tinnitus 'fills in the gap'. It has recently been shown, however, that tinnitus is commonly associated with h... περισσότερα »
The Hidden Dysfunction of Otolithic Organs in Patients with Profound Sensorineural Hearing Loss
Publication date: Available online 28 October 2015 *Source:*Hearing Research Author(s): Xin-Da Xu, Chen-Ru Ding, Jing Yu, Zhao Han, Jun Gu, Na Gao, Xian-Hao Jia, Xu Luo, Jing Wang, Fang-Lu Chi ObjectiveTo define the profiles of ocular and cervical vestibular-evoked myogenic potentials (oVEMP and cVEMP, respectively) in patients with profound sensorineural hearing loss (PSHL).MethodsTwenty-nine patients with PSHL and 20 healthy volunteers were investigated. The patients' medical records were collected and analyzed. The ACS-evoked oVEMPs and cVEMPs and caloric test were tested and ana... περισσότερα »
Immune defense is the primary function associated with the differentially expressed genes in the cochlea following acoustic trauma
Publication date: Available online 28 October 2015 *Source:*Hearing Research Author(s): Shuzhi Yang, Qunfeng Cai, R. Robert Vethanayagam, Jianmin Wang, Weiping Yang, Bo Hua Hu Our previous RNA-sequencing analysis of the rat cochlear genes identified multiple biological processes and molecular pathways in the cochlear response to acoustic overstimulation. However, the biological processes and molecular pathways that are common to other species have not been documented. The identification of these common stress processes is pivotal for a better understanding of the essential response ...περισσότερα »
Cancer, obesity, and legitimation of suggested lifestyles: a libertarian paternalism approach
Giovanni Boniolo and Vincenzo Rebba from Cancer via ola Kala on Inoreader http://ift.tt/1LZXGOT via IFTTT
Open removal of a retained retrohepatic inferior vena cava filter with a residual primary neuroectodermal renal tumoral thrombus
Primary neuroectodermal renal tumours (PNET) are rare and aggressive neoplasms; thrombosis of the inferior vena cava (IVC) is associated with this entity. We report here the case of a 19-year-old man who experienced a new onset of abdominal pain. A CT scan revealed a large left renal mass, perirenal haematoma and IVC thrombosis. Owing to an acute drop in haemoglobin and subsegmentary pulmonary embolism, he underwent emergency selective renal artery angiography and embolisation of bleeding vessels and IVC filter (IVCF) placement. Once stable, he underwent a left radical nephrectomy... περισσότερα »
Successful use of pregabalin by the rectal route to treat chronic neuropathic pain in a patient with complete intestinal failure
Pregabalin is widely used for treatment of neuropathic pain and is only approved for oral use. This is the first reported case of using pregabalin by the rectal route for treatment in a 70-year-old patient with chronic neuropathic pain and complete intestinal failure. Therapies used in an attempt to manage his chronic pain have included a variety of doses and strengths of opioid preparations and cannabinoids, plus topical and alternative therapies. These were not effective, so it was decided to start a trial of pregabalin administered by the rectal route. Serum levels were measure... περισσότερα »
Anti-interleukin 6 receptor therapy for hyper-IgD syndrome
Hyper-IgD syndrome (HIDS) is a rare, severe hereditary autoinflammatory disease characterised by periodic fevers, elevated serum IgD levels and a wide range of symptoms. Although a few randomised controlled trials have been performed in this disorder, there are no straightforward treatment protocols and none of the potential therapies are registered for this indication. We report a case of a young woman with severe HIDS who failed numerous therapies. Eventually, rational treatment with a monoclonal anti-interleukin 6 receptor antibody was initiated. This therapy resulted in an imp...περισσότερα »
Iatrogenic Cushing's syndrome and osteoporosis due to an interaction between fluticasone and ritonavir
The advent of highly active antiretroviral therapy for HIV infection dramatically changed the landscape of the disease. Ritonavir, a protease inhibitor (PI) frequently used in low doses to 'boost' the concentrations of other PIs, inhibits the cytochrome P450 3A4 isoenzyme, a common metabolic pathway to multiple drugs, so the potential for drug interactions is not negligible. A 39-year-old man with HIV-1 infection, treated with a ritonavir-boosted PI, was started on fluticasone/salmeterol inhaler and intranasal fluticasone, in 2009, in the setting of asthma and allergic rhinitis. I...περισσότερα »
Surviving stroke in an Ebola Treatment Centre
A middle aged woman presented to an Ebola Treatment Centre in West Africa with a 4-day history of fever, fatigue, joint pain and vomiting. She tested positive for Ebola virus disease (EVD) and a standard treatment platform of care was started. On day 3 of her admission, she was found to have suffered a left-sided CVA of unknown aetiology. Treatment was largely supportive within a resource-constrained environment and the added layer of providing care with extensive personal protective equipment, and human resource and safety constraints. The patient was able to clear the EVD and did... περισσότερα »
Exploring the possibilities: airspace disease in the postallogeneic haematopoietic stem cell transplant period
A 50-year-old man with a history of myelodysplastic syndrome status postallogeneic haematopoietic stem cell transplantation (HSCT) in July 2013 presented in January 2014 with a 6-week history of worsening shortness of breath and dry cough. Chest imaging revealed scattered groundglass opacities in the upper lobes bilaterally and two areas of focal consolidation on the left side. Bronchoscopy with bronchoalveolar lavage grew methicillin-resistant *Staphylococcus aureus* and the patient was treated with a prolonged course of vancomycin without improvement in symptoms or oxygenation. ...περισσότερα »
Embolisation of an iatrogenic pulmonary artery pseudoaneurysm
A 62-year-old woman with idiopathic cardiomyopathy and class IIIB/stage C heart failure sustained right pulmonary artery injury from a Swan-Ganz catheter during a pretransplant work up. Postprocedure, it was noted that the patient's segmental pulmonary artery catheter was wedged for an unclear period of time. The patient developed a small volume of blood-tinged sputum and a chest CT revealed a 1.3 cm pseudoaneurysm in the right middle lobe medial segment pulmonary artery and a small area of haemorrhage. The patient underwent pulmonary artery preserving coil embolisation of the pse... περισσότερα »
Rheumatoid lung nodule
Description A 61-year-old woman was under treatment with a combination of methotrexate and leflunomide for seropositive rheumatoid arthritis (RA) for the past 6 years. She presented to us 6 months earlier with grade 1 dyspnoea of 3-month duration. She was a non-smoker. On evaluation, her vitals, and respiratory and cardiovascular system were normal. Laboratory reports revealed normal blood count, and renal and liver function tests were also normal. Chest X-ray revealed multiple nodules (in left upper lobe and right lower lobe). CT of the chest confirmed bilateral multiple necroti... περισσότερα »
A case of presumed post-traumatic pneumocephalus
Description Intracranial fat deposits are uncommon benign lesions and are usually incidental findings when the brain is imaged for other reasons. Spontaneous or traumatic dermoid cyst rupture is the putative underlying cause in most cases.1 We describe a case of a 71-year-old woman, who presented 10 days after a fall at home, reporting occipital pain and acute-onset vertical diplopia. On examination, there was no external bruising, but a left trochlear nerve palsy was clinically elicited. CT scan was reported as 'no evidence of orbital/skull fracture or haemorrhage, but widespr... περισσότερα »
Orbital emphysema: nose blowing leading to a blown orbit
A 32-year-old woman with a painful swelling around the right eye few hours after blowing her nose, presented to the accident and emergency department. There was no associated history of facial trauma. Examination revealed a grossly swollen right eye and palpable subcutaneous emphysema. The patient's visual acuity and eye movements were normal. A CT scan of the orbit confirmed orbital emphysema secondary to a fracture of the floor of the orbit into the maxillary sinus, as a result of increased intranasal pressure during nose blowing. The patient was admitted and managed conservativ... περισσότερα »
Macular congenital hypertrophy of retinal pigment epithelium (CHRPE) in a patient with best vitelliform dystrophy (BVD)
Description A 28-year-old woman presented with decreased vision in her right eye for the past 6 months. She also reported several years of low vision in both eyes. There was no history of ocular trauma or previous laser photocoagulation. Best-corrected visual acuity (BCVA) was 6/36 in the right eye and 6/18 in the left. Anterior segment was normal in both eyes. There were no signs of intraocular inflammation. Dilated fundus examination showed peripapillary atrophy and a pigmented lesion at the right macula (figure 1A). This lesion contained depigmented lacunae and had a white rin... περισσότερα »
Patellar tendon enthesitis as initial manifestation of ankylosing spondylitis: an atypical presentation
Description A 19-year-old man presented to the orthopaedic clinic because of a 3-month history of left anterior knee pain. There was apparently no history of trauma or other comorbidities. He was not involved in athletic activities. On physical examination, there was tenderness at the tibial tubercle. He underwent anteroposterior (AP) and lateral radiographs of the left knee, which showed a focal lucency at the tibial tubercle and soft tissue thickening at the distal patellar tendon (figure 1). He further underwent MRI of the knee and AP radiograph of the pelvis. MRI showed featu... περισσότερα »
Anterior and posterior fixation for delayed treatment of posterior atlantoaxial dislocation without fracture
Posterior atlantoaxial dislocation (PAAD) without fracture of the odontoid process is a rare injury. Authors have variously reported closed or open reduction, followed by either anterior or posterior fixation, but there is no consensus on best treatment. We present a particularly unstable case of PAAD. Open reduction through a retropharyngeal approach with odontoidectomy was required for reduction. Anterior fixation with transarticular lag screws was required prior to posterior fixation with pedicle screws. Despite non-compliance with postoperative immobilisation, imaging at 20-mo... περισσότερα »
A rare case of classical Hodgkin's lymphoma in the setting of a newly diagnosed left atrial myxoma
We report a rare case of left atrial myxoma with concomitant classical Hodgkin's lymphoma in a 36-year-old woman with a non-significant medical history and 4 months of progressively worsening palpitations, dyspnoea on exertion, chest discomfort and fatigue. Outpatient echocardiography revealed functional mitral valve stenosis as a result of a large left atrial cardiac mass. Preoperative thoracic imaging revealed an anterior mediastinal mass with associated lymphadenopathy. The patient underwent successful resection of the anterior mediastinal mass and left atrial mass. Surgical pa... περισσότερα »
Local Control Rates of Metastatic Renal Cell Carcinoma (RCC) to Thoracic, Abdominal, and Soft Tissue Lesions Using Stereotactic Body Radiotherapy (SBRT)
Abstract Background and purpose We report the radiographic response rate of SBRT compared to conventional fractionated radiotherapy (CF-EBRT) for thoracic, abdominal, skin and soft tissue RCC lesions treated at our institution. Material and methods Fifty three lesions where included in the study (36 SBRT, 17 CF-EBRT), treated from 2004 to 2014 at our institution. We included patients that had thoracic, skin & soft tissue (SST), and abdominal metastases of histologically confirmed RCC. The most common SBRT fractionation was 50 Gy in 5 fractions. Results The median time of follow-... περισσότερα »
Clinicopathologic features of breast cancers that develop in women with previous benign breast disease
BACKGROUND Women with benign breast disease (BBD) have an increased risk of developing breast cancer (BC). Nearly 30% of all BCs develop in women with prior BBD. Information regarding features of the expected number of BCs after BBD would enhance individualized surveillance and prevention strategies for these women. In the current study, the authors sought to characterize BCs developing in a large cohort of women with BBD. METHODS The current study cohort included 13,485 women who underwent breast biopsy for mammographic or palpable concerns between 1967 and 2001. Biopsy slides ... περισσότερα »
Group trajectory analysis helps to identify older cancer survivors who benefit from distance-based lifestyle interventions
[image: cover.gif?v=1&s=b46e1b4bc04f1fdb7408ed9a] BACKGROUND The number of older cancer survivors is increasing as more adults survive to older ages. The objectives of this study were to examine trajectories of physical activity (PA) and physical function (PF) over a 2-year lifestyle counseling study and to identify characteristics of the trajectory groups. METHODS This was a secondary analysis of Reach Out to Enhance Wellness, a randomized controlled trial of home-based lifestyle counseling. The 641 participants were older (≥65 years), overweight (body mass index [BMI], 25 to <... περισσότερα »
Trends in End-of-Life Care in Pediatric Hematology, Oncology, and Stem Cell Transplant Patients
Background Decisions about end-of-life care may be influenced by cultural and disease-specific features. We evaluated associations of demographic variables (race, ethnicity, language, religion, and diagnosis) with end-of-life characteristics (Phase I enrollment, do-not-resuscitate (DNR) orders, hospice utilization, location of death), and trends in palliative care services delivered to pediatric hematology, oncology, and stem cell transplant (SCT) patients. Procedure In this single-center retrospective cohort study, inclusion criteria were as follows: patients aged 0–35 who died... περισσότερα »
Skin Cancer Surveillance Behaviors Among Childhood Cancer Survivors
The risk of developing skin cancer is elevated among childhood cancer survivors (CCS), particularly among those treated with radiation. This survey study examined the skin cancer surveillance behaviors of 94 CCS. Approximately 48% of CCS had ever conducted skin self-examination (SSE) and 31% had ever received a physician skin examination. Rates of physician skin examination were 2.5 times higher among CCS treated with radiation compared to those without radiation. However, rates of SSEs did not differ based on treatment history. These findings highlight the need to promote skin ca...περισσότερα »
Coexpression of Multiple ABC-Transporters is Strongly Associated with Treatment Response in Childhood Acute Myeloid Leukemia
Background To analyze whether expression of ABC-transporters is associated with remission rate and long-term outcome in a prospective clinical trial of childhood acute myeloid leukemia (AML). Procedure The expression of four ABC-transporter genes (*ABCA3* encoding drug transporter ABCA3, *ABCB1* encoding multidrug resistance protein 1, *ABCC3* encoding multidrug resistance-associated protein 3, and *ABCG2* encoding breast cancer resistance protein) was measured by TaqMan real time polymerase chain reaction in pretreatment samples from 112 children with AML. Patients were treated...περισσότερα »
Colorectal polyp prevention by daily aspirin use is abrogated among active smokers
Abstract Purpose Based on suggestive findings from a recent study of high-risk Japanese patients, we sought to determine whether the risk of colorectal polyps associated with smoking may be modified by daily use of aspirin in an analysis of a large US screening population. Methods This is a cross-sectional study of 2,918 consecutive colonoscopy patients at a university hospital over a 30-month period. Data were abstracted from electronic medical records. Multivariate models of polyp counts were used to examine the competing risks of smoking and aspirin use. Models were further st... περισσότερα »
Antitumor activity of the multikinase inhibitor regorafenib in patient-derived xenograft models of gastric cancer
Abstract Background Unresectable gastric cancer is associated with poor outcomes, with few treatment options available after failure of cytotoxic chemotherapy. Clinical trials of targeted therapies have generally shown no survival benefit in gastric cancer, with the exceptions of the antibodies ramucirumab (anti-VEGFR2) and trastuzumab (anti-HER2/neu). Given the efficacy of the multikinase inhibitor regorafenib in other gastrointestinal tumors, we investigated its potential in gastric cancer. Methods The antitumor activity of oral regorafenib was assessed in eight murine patient-... περισσότερα »
HOXD9 promotes epithelial–mesenchymal transition and cancer metastasis by ZEB1 regulation in hepatocellular carcinoma
Abstract Hepatocellular carcinoma (HCC) is a common malignant tumor that severely threatens human health. The poor prognosis of HCC is mainly attributed to intrahepatic and extrahepatic metastases. HOXD9 proteins belong to a superfamily that regulates the development and control of many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. HOXD9 can also function as an oncogene in several cancer cells. However, its biological function in human HCC requires further investigation. In this study, HOXD9 exhibited high expression in invasive HCC cells.... περισσότερα »
Correlation between mutations and mRNA expression of APC and MUTYH genes: new insight into hereditary colorectal polyposis predisposition
Abstract Background Transcript dosage imbalance may influence the transcriptome. To gain insight into the role of altered gene expression in hereditary colorectal polyposis predisposition, in the present study we analyzed absolute and allele-specific expression (ASE) of *adenomatous polyposis coli* (*APC*) and *mutY Homolog* (*MUTYH*) genes. Methods We analyzed DNA and RNA extracted from peripheral blood mononuclear cells (PBMC) of 49 familial polyposis patients and 42 healthy blood donors selected according similar gender and age. Patients were studied for germline alterations i...περισσότερα »
New Partial Wrist Implant to Help Relieve Arthritic Pain, Maintain Range of Motion
[image: wrist-implant] At the Hospital for Special Surgery (HSS) in Manhattan surgeons are testing a new partial wrist implant designed to alleviate pain due to arthritis while preserving a natural range of motion. The device was developed by Dr. Scott Wolfe, a hand and upper extremity surgeon at HSS, and *Extremity Medical*, a Parsippany, New Jersey firm that builds custom implants. It took over a decade to study the wrist and its motion and to create an implant that takes many factors into account. Previously, wrist surgeries would typically limit hand motion to one plane at a ... περισσότερα »
Fundamentals of Robotic Surgery Training Course Uses New Device to Improve Skills
[image: laparoscopy-training] The Florida Hospital Nicholson Center has unveiled a new robotic surgical training curriculum called Fundamentals of Robotic Surgery (FRS) that includes an online course and a special device to practice clinical skills. The FRS dome device comes in four variants and is used as a model to perform seven exercises. The device lets surgeons practice working with skin and fat layers, either alone or together depending on the demands of the training. Overall, the goal of the training is to improve not just hand manipulation abilities, but cognitive, psycho... περισσότερα »
Addressing the non-functional requirements of computer vision systems: a case study
Abstract Computer vision plays a major role in most autonomous systems and is particularly fundamental within the robotics industry, where vision data are the main input to all navigation and high-level decision making. Although there is significant research into developing and optimising algorithms for feature detection and environment reconstruction, there is a comparative lack of emphasis on how best to map these abstract concepts onto an appropriate software architecture. In this study, we distinguish between functional and non-functional requirements of a computer vision syst... περισσότερα »
Targeted anticancer drug delivery through anthracycline antibiotic bearing functionalized quantum dots.
*Targeted anticancer drug delivery through anthracycline antibiotic bearing functionalized quantum dots.* Artif Cells Nanomed Biotechnol. 2015 Oct 27;:1-9 Authors: Bajwa N, Kumar Mehra N, Jain K, Kumar Jain N Abstract We herein first report a method for the synthesis of chitosan (CHI)-folate conjugated colloidal ZnO-Mn(+2) quantum dots (QDs) bearing doxorubicin through chemical method (DOX/FA-CHI-QDs) for cancer therapy as well imaging purpose. The entrapment efficiency was determined to be 99.98 ± 0.012% (DOX/FA-CHI-QDs) and 92.0 ± 2.62% (DOX-QDs). The developed DOX/FA-CHI-QDs ... περισσότερα »
Intra-Islet Pancreatic Ducts Can Give Rise to Insulin-Positive Cells
Endocrinology, Early Release. from Endocrinology via ola Kala on Inoreader http://ift.tt/1LW0PPU via IFTTT
Gelatin-loaded p(HEMA-GMA) cryogel for high-capacity immobilization of horseradish peroxidase.
*Gelatin-loaded p(HEMA-GMA) cryogel for high-capacity immobilization of horseradish peroxidase.* Artif Cells Nanomed Biotechnol. 2015 Oct 27;:1-6 Authors: Soomro R, Perçin I, Memon N, Iqbal Bhanger M, Denizli A Abstract Poly(2-hydroxyethyl methacrylate-glycidyl methacrylate) [p(HEMA-GMA)] cryogel discs were prepared under sub-zero temperatures. Gelatin was attached covalently on the p(HEMA-GMA) cryogel discs and reversible immobilization of horseradish peroxidase (HRP) was performed. The p(HEMA-GMA) cryogel discs were characterized by swelling tests, scanning electron microscopy... περισσότερα »
Return of Genetic Results: Family Decision Maker Preferences for Whole Genome Sequencing
[image: shutterstock_2514353351.jpg] The return of genetic findings to donors—or to family decision makers (FDMs) in the case of deceased donors—is a relevant ethical issue for biobanks and research projects that employ whole genome sequencing. The National Institute of Health's Genotype-Tissue Expression Project (GTEx) currently opts against sharing research results. This policy is at odds with previous data Read the rest of this article The post Return of Genetic Results: Family Decision Maker Preferences for Whole Genome Sequencing appeared first on Accelerating Science. from...περισσότερα »
A Case Study on Vocal Loudness With a Young Adult With Autism Spectrum Disorder and Developmental Delay
Purpose This clinical focus article describes an exploratory case study addressing reduction of vocal loudness in a young adult with a history of autism spectrum disorder and developmental delay. The need for a short-term pullout individual intervention arose from his participation in the Advancing Language and Literacy group, a program that provides support for enhancement of speech, language, and literacy skills for young adults with developmental disabilities. Method The participant attended individual treatment sessions weekly for 9 sessions, all of which were digitally audio-re... περισσότερα »
Active Cooling and Strain-Ratios to Increase the Actuation Frequency of SMA Wires
Abstract The maximum actuation frequency of an SMA wire does not only depend on the heating and cooling rates but also on the amplitude of strains at which it works. Smaller working amplitudes mean faster working frequencies. SMA-based actuators rarely work throughout their full strain range but they usually work at small amplitudes, which are amplified by means of mechanisms or by the optimised positioning of the wires within the actuator. Furthermore, the nonlinear relationship between the temperature and the strain on SMAs can be used in our favour to increase the actuation fre...περισσότερα »
Patient Self-esteem With Perceived Outcome After Face-lift Surgery
This survey of patients reports that those with low preoperative self-esteem had an increase in self-esteem after face-lift surgery, those with average preoperative self-esteem experienced no change, and those with high preoperative self-esteem had a decrease in self-esteem after surgery. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1PSUsmj via IFTTT
Global Perspective of Beauty in a Multicultural World
This Viewpoint explains why it is important not to assume which culture the patient identifies with most and why it is imperative that a facial plastic surgeon understands a patient's ethnic identity and aesthetic goals prior to any procedure. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1NDgvu1 via IFTTT
The Role of Ideal Angles, Ratios, and Divine Proportions in Aesthetic Evaluation of Adolescents
Abstract Objectives The aim of our study was to investigate whether the parameters of ideal angles, ratios, and divine proportions that have been previously mentioned in the literature influence the aesthetic evaluation of Turkish adolescents. Materials and Methods A total of sixty patients (30 males and 30 females) were enrolled in this study. Ages of the subjects ranged from 9 to 17. Pre-treatment extra-oral photographs were taken to evaluate facial aesthetics. Two distinct panels consisting of 50 orthodontists and 50 laypersons were created for scoring the photographs of the pa... περισσότερα »
Identifying User Interaction Patterns in E-Textbooks
We introduce a new architecture for e-textbooks which contains two navigational aids: an index and a concept map. We report results from an evaluation in a university setting with 99 students. The interaction sequences of the users were captured during the user study. We found several clusters of user interaction types in our data. Three separate user types were identified based on the interaction sequences: passive user, term clicker, and concept map user. We also discovered that with the concept map interface users started to interact with the application significantly sooner th... περισσότερα »
Persea americana Glycolic Extract: In Vitro Study of Antimicrobial Activity against Candida albicans Biofilm and Cytotoxicity Evaluation
This study evaluated the antifungal activity of Persea americana extract on Candida albicans biofilm and its cytotoxicity in macrophage culture (RAW 264.7). To determine the minimum inhibitory concentration (MIC), microdilution in broth (CLSI M27-S4 protocol) was performed. Thereafter, the concentrations of 12.5, 25, 50, 100, and 200 mg/mL with 5 min exposure were analyzed on mature biofilm in microplate wells for 48 h. Saline was used as control . After treatment, biofilm cells were scraped off and dilutions were plated on Sabouraud dextrose agar. After incubation (37°C/48 h), th... περισσότερα »
An Efficient Framework for Large Scale Multimedia Content Distribution in P2P Network: I2NC
Network coding (NC) makes content distribution more effective and easier in P2P content distribution network and reduces the burden of the original seeder. It generalizes traditional network routing by allowing the intermediate nodes to generate new coded packet by combining the received packets. The randomization introduced by network coding makes all packets equally important and resolves the problem of locating the rarest block. Further, it reduces traffic in the network. In this paper, we analyze the performance of traditional network coding in P2P content distribution network... περισσότερα »
Radiopacity of Esthetic Post Materials: Evaluation with Digital Analysis Technique
Abstract Purpose To evaluate the radiopacity of five post materials using a digital image analysis method. Materials and Methods Twelve specimens from each post type (two zirconia and three fiber based) of 2 mm in thickness were obtained using a diamond blade mounted on a cutting machine, and digital radiographs were taken along with aluminum step-wedge and dentin discs under standard exposure conditions. The mean gray-values of specimens were measured using a computer graphics program. Data were analyzed using one-way ANOVA followed by Holm-Sidak multicomparison test (p = 0.05)...περισσότερα »
Inhibition of dentine collagen degradation by hesperidin: an in situ study
Dentine caries is a process of demineralization and subsequent degradation of the collagenous matrix. Host-derived proteolytic enzymes, such as matrix metalloproteinases (MMPs), play a role in this process of dentine collagen degradation. Hampering this degradation retards the caries process. Dietary antioxidants, such as the flavonoid hesperidin, can inhibit the proteolytic activity of MMPs and act as natural stabilizers of collagen. The aim of this study was to investigate the anti-collagenolytic activity of hesperidin in an in situ model. A single-blind, split-mouth, in situ e...περισσότερα »
Electrical stimulation with periodic alternating intervals stimulates neuronal cells to produce neurotrophins and cytokines through activation of mitogen-activated protein kinase pathways
Peripheral neuropathy is a representative complication of dental surgery. Electrical therapy, based on electrical stimulation with periodic alternating intervals (ES-PAI), may promote nerve regeneration after peripheral nerve injury in a non-invasive manner, potentially providing an effective therapy for neuropathy. This study aimed to analyze the molecular mechanisms underlying the nerve recovery stimulated by ES-PAI. In brief, ES-PAI was applied to a neuronal cell line, Neuro2A, at various intensities using the pulse generator apparatus, FREUDE. Cell viability, neurotrophin mRN... περισσότερα »
OtoRhinoLaryngology New Articles & Online Medical Journals,October 29th,2015
Evaluation of low doses BPA-induced perturbation of glycemia by toxicogenomics points to a primary role of pancreatic islets and to the mechanism of toxicity Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα *Evaluation of low doses BPA-induced perturbation of glycemia by toxicogenomics points to a primary role of pancreatic islets and to the mechanism of toxicity* Cell Death and Disease 6, e1959 (October 2015). doi:10.1038/cddis.2015.319 Authors: E Carchia, I Porreca, P J Almeida, F D'Angelo, D Cuomo, M Ceccarelli, M De Fe...περισσότερα »
Diffusion of Na(I), Cs(I), Sr(II) and Eu(III) in smectite rich natural clay
Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 1 Author(s): Sharayu Kasar, Sumit Kumar, R.K. Bajpai, B.S. Tomar Diffusion of Na(I), Cs(I), Sr(II) and Eu(III) in smectite rich natural clay, proposed as a backfill material in the Indian geological repository, was studied using the out-diffusion method. Radiotracers 22Na, 137Cs, 85Sr and 154Eu were used; the first three are carrier-free enabling experimental work at sub-micromolar metal ion concentration, and Eu(III) tracer 154Eu was used at sub millimolar concentration. An out-diffusion... περισσότερα »
Interception and transfer of wet-deposited 134Cs to potato foliage and tubers
Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 1 Author(s): K. Rosén, M. Vinichuk Contamination levels on potato foliage and tubers were investigated by repeated sampling after multiple foliar contaminations of wet-deposited 134Cs at five different growth stages in a micro-plot field experiment in three successive years. Application of the radionuclide early in the growing season (deposition date 19–27 June, growth stage II = plant establishment) resulted in low 134Cs activity concentration in potato tubers across sampling occasions ... περισσότερα »
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Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
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heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
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