OtoRhinoLaryngology & Medicine,New Articles,November 13th,2015

Chemoradiotherapy versus transoral robotic surgery for human papillomavirus-associated, clinical N2 oropharyngeal cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Cost-effectiveness analysis of via International Journal of Radiation Oncology*Biology*Physics *Source:*International Journal of Radiation Oncology*Biology*Physics Author(s): David J. Sher, Mary Jo Fidler, Roy B. Tishler, Kerstin Stenson, Samer al-Khudari PurposeThe prevalence of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is rapidly rising. The optimal therapy for this disease is controversial, as primary chemoradiotherapy (CRT) and TORS (transoral robotic surgery) are effective, competing modalities, with each associated with different streng...περισσότερα »

Machine Learning Approaches for Predicting Radiation Therapy Outcomes

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα

: A Clinician's Perspective via International Journal of Radiation Oncology*Biology*Physics Publication date: 1 December 2015 *Source:*International Journal of Radiation Oncology*Biology*Physics, Volume 93, Issue 5 Author(s): John Kang, Russell Schwartz, John Flickinger, Sushil Beriwal Radiation oncology has always been deeply rooted in modeling, from the early days of isoeffect curves to the contemporary Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) initiative. In recent years, medical modeling for both prognostic and therapeutic purposes has exploded thanks t...περισσότερα »

De-intensified Chemoradiation Therapy for Favorable-Risk Human Papillomavirus–Associated Oropharyngeal Squamous Cell Carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα

Phase 2 Trial of Publication date: 1 December 2015 *Source:*International Journal of Radiation Oncology*Biology*Physics, Volume 93, Issue 5 Author(s): Bhishamjit S. Chera, Robert J. Amdur, Joel Tepper, Bahjat Qaqish, Rebecca Green, Shannon L. Aumer, Neil Hayes, Jared Weiss, Juneko Grilley-Olson, Adam Zanation, Trevor Hackman, William Funkhouser, Nathan Sheets, Mark Weissler, William Mendenhall Purpose To perform a prospective, multi-institutional, phase 2 study of a substantial decrease in concurrent chemoradiation therapy (CRT) intensity as primary treatment for favorable-risk, hu...περισσότερα »

Parent perceptions and practices regarding sleep in children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα

Parent perceptions and practices regarding sleep in children: Abstract BackgroundA good night’s sleep is highly important for children’s healthy development. Therefore, it is also important to provide parents with information on sleep and disturbed sleep of children. ObjectiveLittle is known about German parents’ knowledge about sleep in children, or about how parents react when faced with children’s sleep problems. Therefore, a preliminary, primarily descriptive demographic survey was carried out. Materials and methodsA questionnaire comprising theoretical and applied item... περισσότερα »

Environment-dependent denoising autoencoder for distant-talking speech recognition

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα

Environment-dependent denoising autoencoder for distant-talking speech recognition: In this paper, we propose an environment-dependent denoising autoencoder (DAE) and automatic environment identification based on a deep neural network (DNN) with blind reverberation estimation for robust distant-talking speech recognition. Recently, DAEs have been shown to be effective in many noise reduction and reverberation suppression applications because higher-level representations and increased flexibility of the feature mapping function can be learned. However, a DAE is not adequate in mismat... περισσότερα »

On the Consequences of Purging and Linkage on Fitness and Genetic Diversity

Alexandros G. SfakianakisστοEvolution of a geneΠριν από 10 δευτερόλεπτα

Using computer simulation we explore the consequences of linkage on the inbreeding load of an equilibrium population, and on the efficiency of purging and the loss of genetic diversity after a reduction in population size. We find that linkage tends to cause increased inbreeding load due to the built up of coupling groups of (partially) recessive deleterious alleles. It also induces associative overdominance at neutral sites but rarely causes increased neutral genetic diversity in equilibrium populations. After a reduction in population size, linkage can cause some delay both for ... περισσότερα »

Downregulation of the Canonical WNT Signaling Pathway by TGFβ1 Inhibits Photoreceptor Differentiation of Adult Human Müller Glia with Stem Cell Characteristics

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα

Stem Cells and Development , Vol. 0, No. 0. from Cell via ola Kala on Inoreader http://ift.tt/1GZMAgi via IFTTT

Downregulation of the Canonical WNT Signaling Pathway by TGFβ1 Inhibits Photoreceptor Differentiation of Adult Human Müller Glia with Stem Cell Characteristics

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα

Stem Cells and Development , Vol. 0, No. 0. from Cell via ola Kala on Inoreader http://ift.tt/1GZMAgi via IFTTT

“Herbal seizures” – atypical symptoms after ibogaine intoxication: a case report

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 11 δευτερόλεπτα

IntroductionMisuse of various new psychotropic substances such as ibogaine is increasing rapidly. Knowledge of their negative side effects is sparse.Case presentationWe present a case of intoxication with the herbal substance ibogaine in a 22-year-old white man. After taking a cumulative dose of 38 g (taken in two doses), he developed visual memories, nausea and vomiting. He developed a generalized tonic–clonic seizure with additional grand mal seizures. He was treated with midazolam and levetiracetam. Extended drug screenings and computed tomography and magnetic resonance imaging...περισσότερα »

Syringomatous adenoma of the nipple: a case report

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 11 δευτερόλεπτα

IntroductionSyringomatous adenoma of the nipple is a very rare benign tumor. To the best of our knowledge, there are no reports of a syringomatous adenoma of the nipple metastasizing, although these tumors are known to infiltrate locally and to recur if not totally resected.Case presentationOur patient was a 41-year-old Japanese woman who complained of stiffness of her right nipple with abnormal discharge. Local resection of the tumor was performed. The pathological diagnosis was syringomatous adenoma of the nipple, and the resection margin was found to be positive. Accordingly, a... περισσότερα »

Technical Note: Development and validation of an open data format for CT projection data

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 12 δευτερόλεπτα

Technical Note: Development and validation of an open data format for CT projection data: Purpose: Lack of access to projection data from patient CT scans is a major limitation for development and validation of new reconstruction algorithms. To meet this critical need, this work developed and validated a vendor-neutral format for CT projection data, which will further be employed to build a library of patient projection data for public access. Methods: A digital imaging and communication in medicine (DICOM)-like format was created for CT projection data (CT-PD), named the DICOM-... περισσότερα »

CellSight Technologies

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 13 δευτερόλεπτα

Hangout with Dr Yaghoubi of CellSight Technologies: [image: Dr-Yaghoubi] Medgadget’s John Bennett is hosting a hangout with Shahriar Yaghoubi, Ph.D., MBA. Dr Yaghoubi has been doing pre-clinical and clinical research for over 20 years, now holding a position as CSO/Director of Clinical Research and Scientific Affairs/MSL at *CellSight Technologies*. The company develops molecular imaging technologies for cancer diagnostics and Dr Yaghoubi has been with the firm from the very beginning. The post Hangout with Dr Yaghoubi of CellSight Technologies appeared first on Medgadget.

Saliency-weighted graphs for efficient visual content description and their applications in real-time image retrieval systems

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 13 δευτερόλεπτα

Saliency-weighted graphs for efficient visual content description and their applications in real-time image retrieval systems: AbstractThe exponential growth in the volume of digital image databases is making it increasingly difficult to retrieve relevant information from them. Efficient retrieval systems require distinctive features extracted from visually rich contents, represented semantically in a human perception-oriented manner. This paper presents an efficient framework to model image contents as an undirected attributed relational graph, exploiting color, texture, layout, a... περισσότερα »

Graphite Screen-Printed Electrodes Applied for the Accurate andReagentless Sensing of pH

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 13 δευτερόλεπτα

Graphite Screen-Printed Electrodes Applied for the Accurate and Reagentless Sensing of pH: [image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b01236

Construct Validity of the Ecological Momentary Assessment in Audiology Research.

Alexandros G. SfakianakisστοHead and NeckΠριν από 15 δευτερόλεπτα

Construct Validity of the Ecological Momentary Assessment in Audiology Research.: Related Articles*Construct Validity of the Ecological Momentary Assessment in Audiology Research.* J Am Acad Audiol. 2015 Nov-Dec;26(10):872-84 Authors: Wu YH, Stangl E, Zhang X, Bentler RA Abstract BACKGROUND: Ecological momentary assessment (EMA) is a methodology involving repeated assessments/surveys to collect data describing respondents' current or very recent experiences and related contexts in their natural environments. The use of EMA in audiology research is growing. PURPOSE: This study ex... περισσότερα »

Evaluation of predictor variables of diagnostic [18F] FDG-PET/CT in fever of unknown origin.

Alexandros G. SfakianakisστοHead and NeckΠριν από 15 δευτερόλεπτα

Evaluation of predictor variables of diagnostic [18F] FDG-PET/CT in fever of unknown origin.: Related Articles*Evaluation of predictor variables of diagnostic [18F] FDG-PET/CT in fever of unknown origin.* Q J Nucl Med Mol Imaging. 2015 Nov 10; Authors: Okuyucu K, Alagoz E, Demirbas S, Ince S, Karakas A, Karacalioglu O, Gunalp B, Arslan N Abstract AIM: Fever of unknown origin (FUO) is defined as an illness having fever which lasts at least 3 weeks of duration and is higher than 38.3 oC on several measurements. The causes are infections, malignancies, noninfectious inflammatory di... περισσότερα »

Teratogenically induced clefts and the anti-teratogenic effect of thiamine

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα

Sex distribution is a factor in teratogenically induced clefts and in the anti-teratogenic effect of thiamine in mice, but not in genetically determined cleft appearance via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 12 November 2015 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Konstanze Scheller, Florian Kalmring, Johannes Schubert PurposeCleft lip and/or palate (CL/P) shows a gender-related distribution in human beings. The reason is unknown. This study analyzed the gender-related cleft appearance with respect t... περισσότερα »

Random control trials in oral and maxillofacial surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα

Association between funding, risk of bias, and outcome of random control trials in oral and maxillofacial surgery via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 12 November 2015 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): M.A.E.M. Oomens, S. Lazarri, M.W. Heymans, T. Forouzanfar The influence of funding on the main outcome of a random control trial (RCT) is important, as it could potentially lead to bias towards industry, and results that are too optimistic. We investigated the association between funding, the published... περισσότερα »

Neuroimmunotherapies Targeting T Cells: From Pathophysiology to Therapeutic Applications

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα

Neuroimmunotherapies Targeting T Cells: From Pathophysiology to Therapeutic Applications: AbstractTherapeutic options for multiple sclerosis (MS) have significantly increased over the last few years. T lymphocytes are considered to play a central role in initiating and perpetuating the pathological immune response. Currently approved therapies for MS target T lymphocytes, either in an unspecific manner or directly by interference with specific T-cell pathways. While the concept of “T-cell-specific therapy” implies specificity and selectivity, currently approved approaches come from... περισσότερα »

Fixation of skin grafts in total and extensive defects of the scalp

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα

Fixation of skin grafts in total and extensive defects of the scalp via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 12 November 2015 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Pedro Manuel Losa, Jorge Guiñales, María José Morán, Miguel Burgueño Figures and tables 1. [image: Total scalp defect with maxillomandibular fixation screws and sutures tied over ...] 2. [image: Patient 3 weeks later.]

Clinical practice guidelines for the diagnosis and treatment of patients with soft tissue sarcoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

Clinical practice guidelines for the diagnosis and treatment of patients with soft tissue sarcoma by the Spanish group for research in sarcomas (GEIS): AbstractSoft tissue sarcomas (STS) constitute an uncommon and heterogeneous group of tumours, which require a complex and specialized multidisciplinary management. The diagnostic approach should include imaging studies and core needle biopsy performed prior to undertaking surgery. Wide excision is the mainstay of treatment for localized sarcoma, and associated preoperative or postoperative radiotherapy should be administered in high...περισσότερα »

Antimitotic drugs in the treatment of cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

Antimitotic drugs in the treatment of cancer: AbstractCancer is a complex disease since it is adaptive in such a way that it can promote proliferation and invasion by means of an overactive cell cycle and in turn cellular division which is targeted by antimitotic drugs that are highly validated chemotherapy agents. However, antimitotic drug cytotoxicity to non-tumorigenic cells and multiple cancer resistance developed in response to drugs such as taxanes and vinca alkaloids are obstacles faced in both the clinical and basic research field to date. In this review, the classes of ant... περισσότερα »

Melanoma Thickness and Survival Trends

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα

Melanoma Thickness and Survival Trends in the United States, 1989 to 2009: Background: With melanoma incidence rising and mortality stable, some question whether the melanoma epidemic is real. Melanoma thickness and survival trends may provide insights, but previous studies have been limited because of missing data on thickness. Methods: With a validated imputation method for missing thickness data, we characterized melanoma thickness and survival trends among men and women in the Surveillance, Epidemiology, and End Results (SEER)–9 registries between 1989 and 2009. A total of 98,...περισσότερα »

Monosialotetrahexosylganglioside Inhibits the Expression of p-CREB and NR2B in the Auditory Cortex in Rats with Salicylate-Induced Tinnitus.

Alexandros G. SfakianakisστοHead and NeckΠριν από 22 δευτερόλεπτα

Monosialotetrahexosylganglioside Inhibits the Expression of p-CREB and NR2B in the Auditory Cortex in Rats with Salicylate-Induced Tinnitus.: Related Articles*Monosialotetrahexosylganglioside Inhibits the Expression of p-CREB and NR2B in the Auditory Cortex in Rats with Salicylate-Induced Tinnitus.* Clin Lab. 2015;61(9):1113-8 Authors: Song RB, Lou WH Abstract BACKGROUND: This study investigated the effects of monosialotetrahexosylganglioside (GM1) on the expression of N-methyl-D-aspartate receptor subunit 2B (NR2B) and phosphorylated (p)-cyclic AMP response element-binding prot... περισσότερα »

Estimation of Aluminum, Arsenic, Lead and Nickel Status in the Samples of Different Cigarettes and their Effect on Human Health of Irish Smoker Hypertensive Consumers.

Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 23 δευτερόλεπτα

Estimation of Aluminum, Arsenic, Lead and Nickel Status in the Samples of Different Cigarettes and their Effect on Human Health of Irish Smoker Hypertensive Consumers.: Related Articles*Estimation of Aluminum, Arsenic, Lead and Nickel Status in the Samples of Different Cigarettes and their Effect on Human Health of Irish Smoker Hypertensive Consumers.* Clin Lab. 2015;61(9):1147-56 Authors: Afridi HI, Talpur FN, Kazi TG, Brabazon D Abstract BACKGROUND: Cigarette smoking interferes with the metal homeostasis of the human body, which plays a crucial role for maintaining health. A s...περισσότερα »

Rs219780 SNP of Claudin 14 Gene is not Related to Clinical Expression in Primary Hyperparathyroidism.

Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 23 δευτερόλεπτα

Rs219780 SNP of Claudin 14 Gene is not Related to Clinical Expression in Primary Hyperparathyroidism.: Related Articles*Rs219780 SNP of Claudin 14 Gene is not Related to Clinical Expression in Primary Hyperparathyroidism.* Clin Lab. 2015;61(9):1197-203 Authors: Piedra M, Berja A, García-Unzueta MT, Ramos L, Valero C, Amado JA Abstract BACKGROUND: The CLDN14 gene encodes a protein involved in the regulation of paracellular permeability or ion transport at epithelial tight junctions as in the nephron. The C allele of the rs219780 SNP (single nucleotide polymorphism) of CLDN14 has b... περισσότερα »

Peripheral blood antigen presenting cell responses in otitis-prone and non-otitis-prone infants

Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 23 δευτερόλεπτα

Stringently defined otitis-prone (sOP) children represent a new classification of the otitis-prone condition. Previous studies showed dysfunction in Ab, B-cell memory and T-cell memory responses. We sought to determine whether there are defects in numbers, phenotype and/or function of professional APC in the peripheral blood of sOP infants. APC phenotypic counts, MHC II expression and intracellular cytokine levels were determined in response to TLR7/8 (R848) stimulation by flow cytometry. Innate immune mRNA expression was measured using RT-PCR and cytokines were measured using Lum...περισσότερα »

Photodynamic Therapy-Induced Apoptosis of Keloid Fibroblasts is Mediated by Radical Oxygen Species In Vitro.

Alexandros G. SfakianakisστοHead and NeckΠριν από 25 δευτερόλεπτα

Photodynamic Therapy-Induced Apoptosis of Keloid Fibroblasts is Mediated by Radical Oxygen Species In Vitro.: Related Articles*Photodynamic Therapy-Induced Apoptosis of Keloid Fibroblasts is Mediated by Radical Oxygen Species In Vitro.* Clin Lab. 2015;61(9):1257-66 Authors: Wang X, Li J, Li L, Li X Abstract BACKGROUND: It has been demonstrated that photodynamic therapy (PDT) is a promising treatment approach for hyperplastic dermatosis and results in a beneficial outcome. In the present study, PDT involving hematoporphyrin monomethyl ether (HMME) was applied to keloid fibroblasts... περισσότερα »

Increased Neutrophil to Lymphocyte Ratio is Associated with In-Hospital Mortality in Patients with Aortic Dissection.

Alexandros G. SfakianakisστοHead and NeckΠριν από 25 δευτερόλεπτα

Increased Neutrophil to Lymphocyte Ratio is Associated with In-Hospital Mortality in Patients with Aortic Dissection.: Related Articles*Increased Neutrophil to Lymphocyte Ratio is Associated with In-Hospital Mortality in Patients with Aortic Dissection.* Clin Lab. 2015;61(9):1275-82 Authors: Onuk T, Güngör B, Karataş B, Ipek G, Akyüz S, Ozcan KS, Uğur SY, Onuk BE, Yelgeç NS, Kaşikçioğlu H, Cam N Abstract BACKGROUND: i ne prognostic relevance of hematological parameters in cardiovascular diseases has been well demonstrated. The purpose of the present study is to investigate the as... περισσότερα »

Activation of the Blood Coagulation System in Patients with Chronic Spontaneous Urticaria.

Alexandros G. SfakianakisστοHead and NeckΠριν από 25 δευτερόλεπτα

Activation of the Blood Coagulation System in Patients with Chronic Spontaneous Urticaria.: Related Articles*Activation of the Blood Coagulation System in Patients with Chronic Spontaneous Urticaria.* Clin Lab. 2015;61(9):1283-8 Authors: Wang D, Tang H, Shen Y, Wang F, Lin J, Xu J Abstract BACKGROUND: Ninty-five percent of chronic spontaneous urticaria (CSU) patients presented with signs of thrombin generation, and autologous plasma skin tests score positive. The aim of this study was to assess the initiators of blood coagulation that lead to thrombin generation and fibrinolysis... περισσότερα »

The post-transplantation immunosuppressant drugs (ISDs) cyclosporine (CsA) and tacrolimus (TAC)

Alexandros G. SfakianakisστοHead and NeckΠριν από 27 δευτερόλεπτα

Evaluation of the New Cyclosporine and Tacrolimus Automated Electrochemiluminescence Immunoassays under Field Conditions.: Related Articles*Evaluation of the New Cyclosporine and Tacrolimus Automated Electrochemiluminescence Immunoassays under Field Conditions.* Clin Lab. 2015;61(9):1303-15 Authors: Toole B, Gechtman C, Dreier J, Kuhn J, Gutierrez MR, Barrett A, Niederau C Abstract BACKGROUND: Careful monitoring of the post-transplantation immunosuppressant drugs (ISDs) cyclosporine (CsA) and tacrolimus (TAC) in whole blood is essential to prevent adverse drug events. Immunoassay... περισσότερα »

Hypercholesterolemia : CYP2C9 Genetic Polymorphism is a Potential Predictive Marker for the Efficacy of Rosuvastatin Therapy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 27 δευτερόλεπτα

CYP2C9 Genetic Polymorphism is a Potential Predictive Marker for the Efficacy of Rosuvastatin Therapy.: Related Articles*CYP2C9 Genetic Polymorphism is a Potential Predictive Marker for the Efficacy of Rosuvastatin Therapy.* Clin Lab. 2015;61(9):1317-24 Authors: Lin J, Zhang Y, Zhou H, Wang X, Wang W Abstract BACKGROUND: There is well-known inter-individual variability in the cholesterol-lowering effect of statins. However, inter-individual variability in response to rosuvastatin treatment in subjects with hypercholesterolemia has not been clearly established. This study aimed to... περισσότερα »

Influence of Preanalytical Variables on Prothrombin Time, Activated Partial Thromboplastin Time, and Fibrinogen.

Alexandros G. SfakianakisστοHead and NeckΠριν από 27 δευτερόλεπτα

Influence of Preanalytical Variables on Prothrombin Time, Activated Partial Thromboplastin Time, and Fibrinogen.: Related Articles*Influence of Preanalytical Variables on Prothrombin Time, Activated Partial Thromboplastin Time, and Fibrinogen.* Clin Lab. 2015;61(9):1337-40 Authors: Kim H, Kim Y, Lee HK Abstract BACKGROUND: In the present study, the influence of preanalytical variables on prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen testing is investigated. METHODS: Samples collected from 104 patients were used for the study. PT, aPTT, and f... περισσότερα »

[Social media monitoring of asthmatic children treated in a specialized program: Parents and caregivers expectations].

Alexandros G. SfakianakisστοHead and NeckΠριν από 27 δευτερόλεπτα

[Social media monitoring of asthmatic children treated in a specialized program: Parents and caregivers expectations].: Related Articles*[Social media monitoring of asthmatic children treated in a specialized program: Parents and caregivers expectations].* Rev Alerg Mex. 2015 Oct-Dec;62(4):255-264 Authors: Urrutia-Pereira M, Ávila JB, Cherrez-Ojeda I, Ivancevich JC, Solé D Abstract BACKGROUND: Social media has been used in support of patients with asthma. However, it remains unclear what are the expectations of parents or caregivers of asthmatic patients. OBJECTIVE: To evaluate t...περισσότερα »

[Systemic lupus erythematous and CD24v].

Alexandros G. SfakianakisστοHead and NeckΠριν από 27 δευτερόλεπτα

[Systemic lupus erythematous and CD24v].: Related Articles*[Systemic lupus erythematous and CD24v].* Rev Alerg Mex. 2015 Oct-Dec;62(4):265-270 Authors: Jiménez-Uscanga RD, Carsolio-Trujano M, Herrera-Sánchez DA, Castrejón-Vázquez MI, Irazoque-Palacios F, Vargas-Camaño ME, Martínez-Aguilar N, Chima-Galán MC Abstract BACKGROUND: Systemic lupus erythematous is an autoimmune disease of multifactorial etiology with genetic predisposition. Its pathogenesis involved more than 100 genes. CD24 gene can mediate various functions such as their costimulatory activity in the clonal expansion ... περισσότερα »

[Prevalence of asthma and determination of symptoms as risk indicators].

Alexandros G. SfakianakisστοHead and NeckΠριν από 27 δευτερόλεπτα

[Prevalence of asthma and determination of symptoms as risk indicators].: Related Articles*[Prevalence of asthma and determination of symptoms as risk indicators].* Rev Alerg Mex. 2015 Oct-Dec;62(4):271-278 Authors: Mancilla-Hernández E, Medina-Ávalos MA, Barnica-Alvarado RH, Soto-Candia D, Guerrero-Venegas R, Zecua-Nájera Y Abstract BACKGROUND: Asthma is a chronic inflammatory airway disease whose prevalence has increased, especially in developed countries; the results of studies of asthma prevalence vary in different populations and even within the same country; in Mexico we ob... περισσότερα »

[Epidemiologic features in patients with antihistamine-resistant chronic urticaria].

Alexandros G. SfakianakisστοHead and NeckΠριν από 27 δευτερόλεπτα

[Epidemiologic features in patients with antihistamine-resistant chronic urticaria].: Related Articles*[Epidemiologic features in patients with antihistamine-resistant chronic urticaria].* Rev Alerg Mex. 2015 Oct-Dec;62(4):279-286 Authors: Sánchez Borges M, Tassinari S, Flores A Abstract BACKGROUND: Current information on the particular features of patients suffering chronic spontaneous urticaria refractory to treatment is limited. OBJECTIVE: To investigate demographic and clinical characteristics in patients with refractory chronic spontaneous urticaria. MATERIAL AND METHODS: A... περισσότερα »

[Impact of air pollution on the development of asthma].

Alexandros G. SfakianakisστοHead and NeckΠριν από 27 δευτερόλεπτα

[Impact of air pollution on the development of asthma].: Related Articles*[Impact of air pollution on the development of asthma].* Rev Alerg Mex. 2015 Oct-Dec;62(4):287-301 Authors: Sánchez J, Caraballo L Abstract Air pollution affects the origin and evolution of respiratory diseases. The increased frequency of asthma in recent years has been associated with growth air pollutants and small particles produced from the combustion of petroleum or cigarette smoke. Some mechanisms of how these contaminants can influence asthma and other allergic diseases are known: 1) acting as irrita... περισσότερα »

[Phenotypic and functional diversity of B lymphocytes].

Alexandros G. SfakianakisστοHead and NeckΠριν από 27 δευτερόλεπτα

[Phenotypic and functional diversity of B lymphocytes].: Related Articles*[Phenotypic and functional diversity of B lymphocytes].* Rev Alerg Mex. 2015 Oct-Dec;62(4):302-311 Authors: Santos-Argumedo L Abstract For many years, it has been considered that the function of B cells is only to serve as precursors of antibody-producing plasma cells; however, this simplistic view has been challenged in the past thirty years. The first big surprise came during the seventies, when it was shown that B lymphocytes are not a homogeneous population, but is made up of various subpopulations with...περισσότερα »

[Salmonella typhi vaccination response study reveals defective antibody production selective IgA deficiency patient].

Alexandros G. SfakianakisστοHead and NeckΠριν από 27 δευτερόλεπτα

[Salmonella typhi vaccination response study reveals defective antibody production selective IgA deficiency patient].: Related Articles*[Salmonella typhi vaccination response study reveals defective antibody production selective IgA deficiency patient].* Rev Alerg Mex. 2015 Oct-Dec;62(4):318-322 Authors: Pleguezuelo DE, Gianelli C Abstract Selective IgA deficiency (SIgAD) is the most prevalent immunodeficiency worldwide, progressing to common variable immunodeficiency only in few reported cases. We report the case of a Spanish female aged 22 and diagnosed of selective IgA deficie...περισσότερα »

[Bullous systemic lupus mimicking a Stevens-Johnson syndrome].

Alexandros G. SfakianakisστοHead and NeckΠριν από 29 δευτερόλεπτα

[Bullous systemic lupus mimicking a Stevens-Johnson syndrome].: Related Articles*[Bullous systemic lupus mimicking a Stevens-Johnson syndrome].* Rev Alerg Mex. 2015 Oct-Dec;62(4):323-327 Authors: Montoya CL, Echeverri AF, González ML, Tobón G, Serrano CD Abstract Autoimmune bullous diseases represent a diagnostic challenge due to the wide spectrum of pathologies that share similar clinical features. This paper reports the case of a woman admitted with a supposed diagnosis of a Stevens-Johnson syndrome, in which the history, the profile of autoimmunity and interdisciplinary approa... περισσότερα »

Peripheral blood antigen presenting cell responses in otitis-prone and non-otitis-prone infants

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα

Peripheral blood antigen presenting cell responses in otitis-prone and non-otitis-prone infants: Stringently defined otitis-prone (sOP) children represent a new classification of the otitis-prone condition. Previous studies showed dysfunction in Ab, B-cell memory and T-cell memory responses. We sought to determine whether there are defects in numbers, phenotype and/or function of professional APC in the peripheral blood of sOP infants. APC phenotypic counts, MHC II expression and intracellular cytokine levels were determined in response to TLR7/8 (R848) stimulation by flow cytometr... περισσότερα »

New pharmacokinetic/pharmacodynamic studies of systemically administered colistin against Pseudomonas aeruginosa and Acinetobacter baumannii in mouse thigh and lung infection models: smaller response in lung infection

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

New pharmacokinetic/pharmacodynamic studies of systemically administered colistin against Pseudomonas aeruginosa and Acinetobacter baumannii in mouse thigh and lung infection models: smaller response in lung infection: Objectives This study investigated the exposure–response relationships between unbound colistin in plasma and antibacterial activity in mouse thigh and lung infections. Methods Dose fractionation studies (subcutaneous colistin sulphate at 1.25–160 mg/kg/day) were conducted in neutropenic mice in which infection (three strains of *Pseudomonas aeruginosa* and three st... περισσότερα »

Impact of an antimicrobial stewardship-led intervention for Staphylococcus aureus bacteraemia: a quasi-experimental study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

Impact of an antimicrobial stewardship-led intervention for Staphylococcus aureus bacteraemia: a quasi-experimental study: Background *Staphylococcus aureus* bacteraemia (SAB) carries high rates of morbidity and mortality. Antimicrobial stewardship programmes (ASPs) are well situated to promote adherence to quality performance measures in order to optimize the management of SAB and associated clinical outcomes. Methods This uncontrolled pre–post quasi-experimental study evaluated compliance with an ASP-driven comprehensive care bundle and associated clinical outcomes for patients w... περισσότερα »

Omitted doses as an unintended consequence of a hospital restricted antibacterial system: a retrospective observational study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα

Omitted doses as an unintended consequence of a hospital restricted antibacterial system: a retrospective observational study: Objectives The objective of this study was to determine the frequency of omitted doses of antibacterial agents and explore a number of risk factors, including the effect of a restricted antibacterial system. Methods Antibacterial data were extracted from a hospital electronic prescribing and medication administration system for the period 1 January to 30 April 2014. Percentage dose omission rates were calculated. Omission rates for the first dose of antibac... περισσότερα »

Osteoarticular infection caused by MDR Pseudomonas aeruginosa

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα

Osteoarticular infection caused by MDR Pseudomonas aeruginosa: the benefits of combination therapy with colistin plus {beta}-lactams: Objectives In the era of emergence of MDR *Pseudomonas aeruginosa*, osteoarticular infections (OIs) add more difficulties to its treatment. The role of β-lactams (BLs) is questioned and older drugs need to be reconsidered. The objective of this study was to describe our experience in the management of OIs caused by MDR *P. aeruginosa* and evaluate different therapeutic options. Methods This was a retrospective analysis of a prospectively collected co...περισσότερα »

Antibacterial soap containing triclosan (0.3%) was no more effective than plain soap at reducing bacterial contamination when used under ‘real-life’ conditions

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα

Bactericidal effects of triclosan in soap both in vitro and in vivo: Objectives On December 2013, the US FDA proposed a rule stating that manufacturers must provide data to demonstrate that antibacterial soap is more effective than plain soap or water. The objective of the present study was to examine the *in vitro* and *in vivo* bactericidal effect of triclosan (the most widely used antiseptic agent in soap) in soap. Methods Twenty bacterial strains (proposed by the FDA) were exposed to plain and antibacterial soaps (the same formulation as plain soap, but containing 0.3% triclos... περισσότερα »

Susceptibility testing challenges with ceftaroline, MRSA and a 1 mg/L breakpoint

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα

Susceptibility testing challenges with ceftaroline, MRSA and a 1 mg/L breakpoint: Objectives A 1 mg/L susceptibility breakpoint for ceftaroline and staphylococci is universally agreed; EUCAST counts MIC >1 mg/L as resistant whereas CLSI and FDA count 2 mg/L as intermediate and >2 mg/L as resistant. We investigated whether routine diagnostic tests reliably distinguish MICs of 1 versus 2 mg/L. Methods Thirty-five UK laboratories collected *Staphylococcus aureus* isolates and performed tests with 5 μg (as EUCAST) or 30 μg (as CLSI) discs and either confluent growth on Mueller–Hinton ...περισσότερα »

Genetic environment of metallo-{beta}-lactamase genes in Pseudomonas aeruginosa isolates from the UK

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα

Genetic environment of metallo-{beta}-lactamase genes in Pseudomonas aeruginosa isolates from the UK: Objectives We sought to characterize the genetic environment of *bla*VIM and *bla*IMP genes in *Pseudomonas aeruginosa* isolates from the UK; these included members of six previously described prevalent complexes, A–F, which correspond to international ‘high-risk clones’, along with diverse strains. Methods Metallo-β-lactamase (MBL)-encoding class 1 integrons were amplified by PCR from 218 *P. aeruginosa* isolates producing VIM-type (*n* = 196) or IMP-type (*n* = 22) enzymes, refer...περισσότερα »

Acquired macrolide resistance genes in Haemophilus influenzae?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα

authors' response: 1. Christopher T. Atkinson, 2. Dale A. Kunde and 3. Stephen G. Tristram* -Author Affiliations 1. School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia 1. ↵*Corresponding author. Tel: +61-3-63-245469; Fax: +61-3-63-243658; E-mail:stephen.tristram@utas.edu.au Sir, In reply to the letter ‘Comment on: Acquired macrolide resistance genes in*Haemophilus influenzae*?’ by Roberts *et al*.,1 where the authors provide commentary on our respective publications,2,3 we offer the following response. The paper by Roberts ... περισσότερα »

Phylogenetic lineages, clones and {beta}-lactamases in an international collection of Klebsiella oxytoca isolates non-susceptible to expanded-spectrum cephalosporins

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα

Phylogenetic lineages, clones and {beta}-lactamases in an international collection of Klebsiella oxytoca isolates non-susceptible to expanded-spectrum cephalosporins: Objectives The objective of this study was to examine *Klebsiella oxytoca* clonal and phylogenetic diversity, based on an international collection of carriage isolates non-susceptible to expanded-spectrum cephalosporins (ESCs). Methods The study material comprised 68 rectal carriage *K. oxytoca* isolates non-susceptible to ESCs recovered in 2008–11 from patients in 14 hospitals across Europe and Israel. ESC resistance...περισσότερα »

Growth in nurse prescribing of antibiotics

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα

Growth in nurse prescribing of antibiotics: the Scottish experience 2007-13: Objectives The objective of this study was to retrospectively analyse patterns of primary care antibiotic prescribing by nurse prescribers in Scotland. Methods Data on dispensed antibiotic prescriptions written by nurse prescribers in 2007–13 were obtained from the Prescribing Information System, a database of all NHS prescriptions dispensed in Scotland. Results Since 2007, there has been a steady increase in the volume of antibiotic prescribing in primary care undertaken by nurse prescribers. There was ... περισσότερα »

Reduced susceptibility to biocides in Acinetobacter baumannii: association with resistance to antimicrobials, epidemiological behaviour, biological cost and effect on the expression of genes encoding porins and efflux pumps

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα

Reduced susceptibility to biocides in Acinetobacter baumannii: association with resistance to antimicrobials, epidemiological behaviour, biological cost and effect on the expression of genes encoding porins and efflux pumps: Objectives The objective of this study was to analyse whether there is an association between reduced susceptibility to biocides in *Acinetobacter baumannii* and (i) antimicrobial resistance (co-resistance), (ii) prevalent (epidemic) clones, (iii) changes in the fitness or (iv) expression of genes related to efflux pumps and porins. Methods Susceptibility to b...περισσότερα »

Reappearance and treatment of penicillin-susceptible Staphylococcus aureus in a tertiary medical centre

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα

Reappearance and treatment of penicillin-susceptible Staphylococcus aureus in a tertiary medical centre: Objectives The purpose of this study was to describe trends in the prevalence and treatment patterns of penicillin-susceptible *Staphylococcus aureus* (SA) infections. Methods This was a cross-sectional study of MSSA isolates from blood cultures at a tertiary-care centre between 1 January 2003 and 31 December 2012. All blood cultures positive for MSSA drawn during the study period were used to calculate the prevalence of penicillin-susceptible SA. Repeat cultures were excluded ...περισσότερα »

Host specificity in the diversity and transfer of lsa resistance genes in group B Streptococcus

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα

Host specificity in the diversity and transfer of lsa resistance genes in group B Streptococcus: Objectives In group B *Streptococcus* (GBS), cross-resistance to lincosamides, streptogramin A and pleuromutilins (LSAP) is mediated by the acquisition of *lsa* genes. Here, we characterized the diversity, mobility and ecology of *lsa* genes in this species. Methods *lsa* variants were systematically identified by BLAST searches in the genomes of 531 GBS strains from different hosts and geographical origins. The associated phenotypes were determined by a microdilution MIC method. Acqui...περισσότερα »

Oxacillin-susceptible mecA-positive Staphylococcus aureus (OS-MRSA) isolates

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα

Frequent occurrence of oxacillin-susceptible mecA-positive Staphylococcus aureus (OS-MRSA) strains in two African countries: Background Oxacillin-susceptible *mecA*-positive *Staphylococcus aureus* (OS-MRSA) isolates have been increasingly reported worldwide, but data regarding the African continent have not been available. Methods Between 2010 and 2014, 1462 inpatients and healthcare workers were screened for MRSA nasal carriage in São Tomé and Príncipe (STP) and Angola, two Portuguese-speaking African countries (PALOP countries). We determined the presence of the *mecA* gene and ... περισσότερα »

The transmission and control of healthcare-associated MRSA

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα

Impact of mupirocin resistance on the transmission and control of healthcare-associated MRSA: Objectives The objectives of this study were to estimate the relative transmissibility of mupirocin-resistant (MupR) and mupirocin-susceptible (MupS) MRSA strains and evaluate the long-term impact of MupR on MRSA control policies. Methods Parameters describing MupR and MupS strains were estimated using Markov chain Monte Carlo methods applied to data from two London teaching hospitals. These estimates parameterized a model used to evaluate the long-term impact of MupR on three mupirocin us...περισσότερα »

Educating healthcare professionals in antimicrobial stewardship

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα

Educating healthcare professionals in antimicrobial stewardship: can online-learning solutions help?: Education is widely recognized as one of the cornerstones of successful antimicrobial stewardship programmes. There is evidence of important knowledge flaws around antimicrobial prescribing among both medical students and clinicians. Educational interventions improve antimicrobial prescribing, but traditional tools may be insufficient to deliver training to meet the complex demands of global healthcare professionals working across a diverse range of healthcare and resource settings... περισσότερα »

Macrolide resistance in the actinomycete Rhodococcus equi

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 47 δευτερόλεπτα

Novel transferable erm(46) determinant responsible for emerging macrolide resistance in Rhodococcus equi: Objectives The objective of this study was to identify the molecular mechanism of macrolide resistance in the actinomycete *Rhodococcus equi*, a major equine pathogen and zoonotic agent causing opportunistic infections in people. Methods Macrolide-resistant (*n* = 62) and macrolide-susceptible (*n* = 62) clinical isolates of *R. equi* from foals in the USA were studied. WGS of 18 macrolide-resistant and 6 macrolide-susceptible *R. equi* was performed. Representative sequences o... περισσότερα »

Therapeutic drug monitoring of the {beta}-lactam antibiotics

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 47 δευτερόλεπτα

Therapeutic drug monitoring of the {beta}-lactam antibiotics: what is the evidence and which patients should we be using it for?: Traditional antibiotic dosing was not designed for today's escalating antibiotic resistance, lack of novel antibiotics and growing complexity in patient populations. Dosing that ensures optimal antibiotic exposures should be considered essential to increase the likelihood of effective patient treatment. Given the variability in these exposures across different patients, a ‘one-dose-fits-all’ approach is increasingly problematic. Therapeutic drug monitori... περισσότερα »

Return-to-work intervention for cancer survivors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα

Return-to-work intervention for cancer survivors: budget impact and allocation of costs and returns in the Netherlands and six major EU-countries: Abstract BackgroundReturn-to-work (RTW)-interventions support cancer survivors in resuming work, but come at additional healthcare costs. The objective of this study was to assess the budget impact of a RTW-intervention, consisting of counselling sessions with an occupational physician and an exercise-programme. The secondary objective was to explore how the costs of RTW-interventions and its financial revenues are allocated among the ... περισσότερα »

Exertional Dyspnea

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα

Effect of Experimental Modulation of Mood on Perception of Exertional Dyspnea in Healthy Subjects: Background: In many diseases across a range of pathologies (e.g. cardiopulmonary, neuromuscular, cancer), chronic dyspnea, particularly on exertion, is a major debilitating symptom often associated with clinical anxiety/depression. This study aims to explore the interaction between mood state and exertional dyspnea in a healthy population. Methodology: Following familiarization, 20 healthy subjects (27-54 years) performed six 5-min treadmill tests on 3 separate days. On each day subje... περισσότερα »

Associations between chronic diseases and choking deaths

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα

Associations between chronic diseases and choking deaths among older adults in the USA: a cross-sectional study using multiple cause mortality data from 2009 to 2013: Objectives To examine whether the strengths of the associations between chronic diseases and overall choking differ from those of the associations between chronic diseases and only food-related choking. Design This cross-sectional study used nationwide multiple cause mortality files. Setting The USA. Participants Older adults aged 65 years or more died between 2009 and 2013. Main outcome measures Mortality ratio (... περισσότερα »

Genome-Wide Mutational Signature of the Chemotherapeutic Agent Mitomycin C

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα

Genome-Wide Mutational Signature of the Chemotherapeutic Agent Mitomycin C in Caenorhabditis elegans: Cancer therapy largely depends on chemotherapeutic agents that generate DNA lesions. However, our understanding of the nature of the resulting lesions as well as the mutational profiles of these chemotherapeutic agents is limited. Among these lesions DNA interstrand crosslinks are among the more toxic types of DNA damage. Here we have characterized the mutational spectrum of a commonly used DNA interstrand crosslinking agent mitomycin C (MMC). Using a combination of genetic mapping... περισσότερα »

Intracranial Dural Venous Sinuses

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα

Automated Cross-Sectional Measurement Method of Intracranial Dural Venous Sinuses [ADULT BRAIN]: BACKGROUND AND PURPOSE: MRV is an important blood vessel imaging and diagnostic tool for the evaluation of stenosis, occlusions, or aneurysms. However, an accurate image-processing tool for vessel comparison is unavailable. The purpose of this study was to develop and test an automated technique for vessel cross-sectional analysis. MATERIALS AND METHODS: An algorithm for vessel cross-sectional analysis was developed that included 7 main steps: 1) image registration, 2) masking, 3) segme... περισσότερα »

Protrusion of the Infraorbital Nerve into the Maxillary Sinus on CT

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα

Protrusion of the Infraorbital Nerve into the Maxillary Sinus on CT: Prevalence, Proposed Grading Method, and Suggested Clinical Implications [HEAD & NECK]: BACKGROUND AND PURPOSE: The infraorbital nerve arises from the maxillary branch of the trigeminal nerve and normally traverses the orbital floor in the infraorbital canal. Sometimes, however, the infraorbital canal protrudes into the maxillary sinus separate from the orbital floor. We systematically studied the prevalence of this variant. MATERIALS AND METHODS: We performed a retrospective review of 500 consecutive sinus CTs pe...περισσότερα »

Contrast Leakage Patterns from Dynamic Susceptibility Contrast Perfusion MRI in the Grading of Primary Pediatric Brain Tumors [PEDIATRICS]

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα

Contrast Leakage Patterns from Dynamic Susceptibility Contrast Perfusion MRI in the Grading of Primary Pediatric Brain Tumors [PEDIATRICS]: BACKGROUND AND PURPOSE: The pattern of contrast leakage from DSC tissue signal intensity time curves have shown utility in distinguishing adult brain neoplasms, but has limited description in the literature for pediatric brain tumors. The purpose of this study is to evaluate the utility of grading pediatric brain tumors with this technique. MATERIALS AND METHODS: A retrospective review of tissue signal-intensity time curves from 63 pediatric b...περισσότερα »

Acute Preoperative Infarcts and Poor Cerebrovascular Reserve Are Independent Risk Factors for Severe Ischemic Complications following Direct Extracranial-Intracranial Bypass for Moyamoya Disease [ADULT BRAIN]

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα

Acute Preoperative Infarcts and Poor Cerebrovascular Reserve Are Independent Risk Factors for Severe Ischemic Complications following Direct Extracranial-Intracranial Bypass for Moyamoya Disease [ADULT BRAIN]: BACKGROUND AND PURPOSE: Severe ischemic changes are a rare but devastating complication following direct superficial temporal artery to MCA bypass in patients with Moyamoya disease. This study was undertaken to determine whether preoperative MR imaging and/or cerebrovascular reserve assessment by using reference standard stable xenon-enhanced CT could predict such complication... περισσότερα »

Detection of Normal Aging Effects on Human Brain Metabolite Concentrations and Microstructure with Whole-Brain MR Spectroscopic Imaging and Quantitative MR Imaging [ADULT BRAIN]

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα

Detection of Normal Aging Effects on Human Brain Metabolite Concentrations and Microstructure with Whole-Brain MR Spectroscopic Imaging and Quantitative MR Imaging [ADULT BRAIN]: BACKGROUND AND PURPOSE: Knowledge of age-related physiological changes in the human brain is a prerequisite to identify neurodegenerative diseases. Therefore, in this study whole-brain 1H-MRS was used in combination with quantitative MR imaging to study the effects of normal aging on healthy human brain metabolites and microstructure. MATERIALS AND METHODS: Sixty healthy volunteers, 21–70 years of age, wer... περισσότερα »

Superselective Intra-Arterial Ethanol Sclerotherapy of Feeding Artery and Nidal Aneurysms in Ruptured Cerebral Arteriovenous Malformations [PEDIATRICS]

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα

Superselective Intra-Arterial Ethanol Sclerotherapy of Feeding Artery and Nidal Aneurysms in Ruptured Cerebral Arteriovenous Malformations [PEDIATRICS]: SUMMARY: In the endovascular treatment of cerebral arteriovenous malformations, ethanol sclerotherapy is seldom used due to safety concerns. However, when limited reflux of an embolic agent is permissible or when there is a long distance to the target, ethanol may be preferable. We reviewed 10 patients with 14 cerebral AVM feeding artery aneurysms or intranidal aneurysms treated with intra-arterial ethanol sclerotherapy at our insti... περισσότερα »

Mechanical Thrombectomy for Isolated M2 Occlusions

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα

Mechanical Thrombectomy for Isolated M2 Occlusions: A Post Hoc Analysis of the STAR, SWIFT, and SWIFT PRIME Studies [ADULT BRAIN]: BACKGROUND AND PURPOSE: Mechanical thrombectomy is beneficial for patients with acute ischemic stroke and a proximal anterior occlusion, but it is unclear if these results can be extrapolated to patients with an M2 occlusion. The purpose of this study was to examine the technical aspects, safety, and outcomes of mechanical thrombectomy with a stent retriever in patients with an isolated M2 occlusion who were included in 3 large multicenter prospective st... περισσότερα »

In Utero MR Imaging of Fetal Holoprosencephaly

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα

In Utero MR Imaging of Fetal Holoprosencephaly: A Structured Approach to Diagnosis and Classification [PEDIATRICS]: BACKGROUND AND PURPOSE: Holoprosencephaly is a rare developmental brain abnormality with a range of severity. We describe our experience in diagnosing holoprosencephaly in the fetus with in utero MR imaging. We hypothesized that including in utero MR imaging in the diagnostic pathway will improve the detection of holoprosencephaly compared with ultrasonography and allow better assessment of the severity. MATERIALS AND METHODS: We report on holoprosencephaly identified... περισσότερα »

Cerebral Blood Flow Alterations in Acute Sport-Related Concussion

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα

Cerebral Blood Flow Alterations in Acute Sport-Related Concussion: Journal of Neurotrauma , Vol. 0, No. 0. Author information Yang Wang,1,2 Lindsay D. Nelson,3,4 Ashley A. LaRoche,3 Adam Y. Pfaller,3 Andrew S. Nencka,1,2 Kevin M. Koch,1,2 and Michael A. McCrea3,4 1Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin. 2Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin. 3Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin. 4Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin. Address... περισσότερα »

The corpus callosum (CC) and corticospinal tract (CST) have been shown to be particularly vulnerable to concussion

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα

Long-Term Abnormalities in the Corpus Callosum of Female Concussed Athletes: Journal of Neurotrauma , Vol. 0, No. 0. Author information Emilie Chamard,1 Genevieve Lefebvre,1 Maryse Lassonde,1,2 and Hugo Theoret1, 2 1Department of Psychology, University of Montreal, Montreal, Canada. 2Centre de Recherche du CHU Sainte-Justine, Montreal, Canada. Address correspondence to: *Hugo Theoret, PhD* *Centre de Recherche en Neuropsychologie et Cognition (CERNEC)* *Department of Psychology, University of Montreal* *CP 6128, Succ. Centre-Ville* *Montreal, Qc, Canada H3C 3J7* *E-mail:* hugo.theoret@um... περισσότερα »

Time Course and Size of Blood–Brain Barrier Opening in a Mouse Model of Blast-Induced Traumatic Brain Injury

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα

Time Course and Size of Blood–Brain Barrier Opening in a Mouse Model of Blast-Induced Traumatic Brain Injury: Journal of Neurotrauma , Vol. 0, No. 0. Author information Christopher D. Hue,1 Frances S. Cho,1 Siqi Cao,1 Russell E. Nicholls,2 Edward W. Vogel III,1 Cosmas Sibindi,1 Ottavio Arancio,2 Cameron R. “Dale” Bass,3 David F. Meaney,4 and Barclay Morrison III1 1Department of Biomedical Engineering, Columbia University, New York, New York. 2Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York. 3Department of Biomedical E... περισσότερα »

Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα

Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma: There is strong clinical interest in utilizing neural stem cells (NSCs) as carriers for targeted delivery of therapeutics to glioblastoma. Multimodal dynamic in vivo imaging of NSC behaviors in the brain is necessary for developing such tailored therapies, however, such technology is lacking. Here we report a novel strategy for mesoporous silica nanoparticles (MSN)-facilitated NSC tracking in the brain via single-photon emission computed tomography (SPECT)...περισσότερα »

Diagnostic Reference Levels of CT Radiation Dose in Oncology Whole-Body PET/CT

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα

Diagnostic Reference Levels of CT Radiation Dose in Oncology Whole-Body PET/CT: The role of computed tomography in PET/CT imaging includes acquisition techniques for diagnostic, anatomical localization and attenuation correction purposes. Diagnostic reference levels of the volumetric computed tomography dose index (CTDIvol) are available for dedicated CT procedures of selected body regions but similar reference levels for whole-body CT employed in PET/CT exams are limited. This work reports CTDIvol values from sites that conduct whole-body oncology PET/CT exams and participated in ...περισσότερα »

68Ga-DOTATATE PET/CT in the localization of head and neck paragangliomas compared to other functional imaging modalities and CT/MRI

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα

68Ga-DOTATATE PET/CT in the localization of head and neck paragangliomas compared to other functional imaging modalities and CT/MRI: Pheochromocytomas/paragangliomas (PPGLs) overexpress somatostatin receptors (SSTRs) and recent studies have already shown excellent results in the localization of sympathetic succinate dehydrogenase complex, subunit B (SDHB) mutation-related metastatic PPGLs using 68Gallium-DOTA0,Tyr3]Octreotate (68Ga-DOTATATE) positron emission tomography/computed tomography (PET/CT). Therefore, the goal of our study was to assess the clinical utility of this functio... περισσότερα »

Uncertainty Quantification in Internal Dose Calculations for Seven Selected Radiopharmaceuticals

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα

Uncertainty Quantification in Internal Dose Calculations for Seven Selected Radiopharmaceuticals: Dose coefficients of radiopharmaceuticals have been published by the International Commission on Radiological Protection (ICRP) and the Medical Internal Radiation Dose (MIRD) Committee, but without information concerning uncertainties. The uncertainty information of dose coefficients is important, for example, to compare alternative diagnostic methods and choose the method that causes the lowest patient exposure with appropriate and comparable diagnostic quality. For the study presente... περισσότερα »

DNA Damage in Peripheral Blood Lymphocytes of Thyroid Cancer Patients after Radioiodine Therapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα

DNA Damage in Peripheral Blood Lymphocytes of Thyroid Cancer Patients after Radioiodine Therapy: *Objectives:* The aim of the study was to investigate DNA double strand break (DSB) formation and its correlation to the absorbed dose to the blood in patients with surgically-treated differentiated thyroid cancer undergoing their first radioiodine therapy for remnant ablation. *Methods:* 20 patients were included in this study. At least 7 peripheral blood samples were obtained before, and between 0.5 h and 120 h post administration. From the time-activity curves of the blood and the wh... περισσότερα »

Seatbelt syndrome with superior mesenteric artery syndrome: leave nothing to chance!

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα

Seatbelt syndrome with superior mesenteric artery syndrome: leave nothing to chance!: The introduction of seatbelts to legislation has dramatically reduced mortality and morbidity from motor vehicle accidents. However, overtime evidence has emerged of ‘seatbelt syndrome’ (SBS), particularly in the paediatric population. The report describes the diagnosis and management of this rare injury in a 12-year-old boy who sustained a chance lumbar fracture and mesenteric tear resulting in small bowel obstruction. His stay was subsequently complicated by superior mesenteric artery (SMA) synd... περισσότερα »

Is there a role for targeted medical therapies in patients with craniopharyngiomas?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα

Is there a role for targeted medical therapies in patients with craniopharyngiomas?: Future Oncology Ahead of Print. [image: Free first page]

Panitumumab as a possible cause of hematospermia: what is the mechanism?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα

Panitumumab as a possible cause of hematospermia: what is the mechanism?: Future Oncology Ahead of Print. [image: Free first page]

Tumor profiling and the incidentalome

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα

Tumor profiling and the incidentalome: patient decisions and risks: Future Oncology Ahead of Print. Erin Hofstatter*,1, Karishma Mehra1, Melinda Yushak2 & Lajos Pusztai1 *Author for correspondence: erin.hofstatter@yale.edu In recent years, the field of oncology has witnessed rapid advancements in genetic sequencing simultaneously with steeply declining costs of sequencing technology. As a result, genomics-driven cancer medicine and the use of tumor profiling are quickly becoming mainstays of cancer therapy. Oncology patients can benefit from tumor profiling by allowing the sele...περισσότερα »

Cell density regulates cancer metastasis via the Hippo pathway

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα

Cell density regulates cancer metastasis via the Hippo pathway: Future Oncology Ahead of Print. Ghada M Sharif1 & Anton Wellstein*,1 *Author for correspondence: wellstea@georgetown.edu Metastatic spread of cancer cells from the primary tumor site to distant organs is the major cause of death in cancer patients. To disseminate, cancer cells detach from the primary tumor, enter the blood stream and extravasate at distant organ sites such as the liver, lung, bone or brain. While cancer cells are known to evade contact inhibition during growth in culture, we found that cell density... περισσότερα »

Risk of selected dermatological toxicities in cancer patients treated with MEK inhibitors: a comparative systematic review and meta-analysis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Risk of selected dermatological toxicities in cancer patients treated with MEK inhibitors: a comparative systematic review and meta-analysis: Future Oncology Ahead of Print. Omar Abdel-Rahman*,1, Hesham ElHalawani1 & Hoda Ahmed2 *Author for correspondence: omar.abdelrhman@med.asu.edu.eg *Background:* This meta-analysis was conducted aiming at assessing the risk of selected dermatological toxicities associated with *MEK* inhibitors. *Methods:* We considered relevant prospective randomized Phase II and III trials of cancer patients on the three *MEK* inhibitors (trametinib, selum...περισσότερα »

Obstructive sleep apnea and cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Obstructive sleep apnea and cancer: effects of intermittent hypoxia?: Future Oncology Ahead of Print. Obstructive sleep apnea (OSA) is a common disorder characterized by pauses in regular breathing. Apneic episodes lead to recurrent hypoxemia-reoxygenation cycles with concomitant cellular intermittent hypoxia. Studies suggest that intermittent hypoxia in OSA may influence tumorigenesis. This review presents recent articles on the potential role of OSA in cancer development. Relevant research has focused on: molecular pathways mediating the influence of intermittent hypoxia on tum...περισσότερα »

Incidence and prevalence of non-melanoma skin cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Incidence and prevalence of non-melanoma skin cancer in Australia: A systematic review: Abstract Non-melanoma skin cancer (NMSC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is the most common cancer occurring in people with fair skin. Australia has been reported to have the highest incidence of NMSC in the world. Using a systematic search of the literature in EMBASE and Medline, we identified 21 studies that investigated the incidence or prevalence of NMSC in Australia. Studies published between 1948 and 2011 were identified and included in the analysis...περισσότερα »

High-volume hydrodissection for abdominally based free flaps

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

High-volume hydrodissection for abdominally based free flaps: Preliminary results: Introduction A novel method of high-volume hydrodissection that provides both subfascial and intramuscular perforator dissection of deep inferior epigastric perforators has been safely demonstrated in animals. This manuscript demonstrates our preliminary results when translating this technique to humans. Methods A retrospective review was performed of all free-flap breast reconstructions utilizing the high-volume hydrodissection technique performed by the senior author (DS) at the University of Flori... περισσότερα »

The vascularized iliotibial tract graft

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

An anatomical and histological study of the vascularized iliotibial tract graft: Background An examination of the vascular anatomy of the iliotibial tract (IT) has not been previously reported. Because a flap resists infection better than an avascular graft, a vascularized IT graft is useful for reconstructive surgeries pertaining to infected wounds or wounds in contact with artificial material. The purpose of this study was to examine the vascular anatomy of the IT. Materials and Methods The study sample consisted of 39 limbs of freshly frozen cadavers. The study was divided into ... περισσότερα »

The diagnosis of nodular melanoma versus superficial spreading melanoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

An assessment of clinical pathways and missed opportunities for the diagnosis of nodular melanoma versus superficial spreading melanoma: Abstract Background Missed opportunities in the diagnosis of nodular melanoma (NM) carry high prognostic penalties due to the rapid rate of NM growth. To date, an assessment of the pathways to diagnosis of NM versus superficial spreading melanoma (SSM) specifically comparing numbers of opportunities missed to undertake biopsy has not been performed. Methods A retrospective questionnaire of 120 patients (60 NM patients, age and sex matched to 60 SSM...περισσότερα »

Hypoechogenicity of brainstem raphe nuclei is associated with increased attack frequency in episodic migraine

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Hypoechogenicity of brainstem raphe nuclei is associated with increased attack frequency in episodic migraine: Introduction Reduced echogenicity of the brainstem raphe nuclei (BRN) was demonstrated in major depression, possibly indicating serotonergic dysfunction. Postulating that migraine may constitute a "chronic low serotonin syndrome," we aimed to evaluate the echogenicity of midbrain structures, including serotonergic BRN in episodic migraine. Methods Transcranial sonography was performed in 39 patients with episodic migraine (median age 35, interquartile range (IQR): 27–47 ye...περισσότερα »

Post-traumatic headache: Responses of dural mast cells in concussive and blast models of mild traumatic brain injury

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Responses of dural mast cells in concussive and blast models of mild traumatic brain injury in mice: Potential implications for post-traumatic headache: Background Chronic post-traumatic headache (PTH) is one of the most common symptoms of mild traumatic brain injury (mTBI) but its underlying mechanisms remain unknown. Inflammatory degranulation of dural mast cells (MCs) is thought to promote headache, and may play a role in PTH. Whether mTBI is associated with persistent degranulation of dural MCs is yet to be determined. Methods Histochemistry was used to evaluate time course cha...περισσότερα »

Oxygen delivery systems and techniques utilized in cluster headache attacks

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

A review of the current and potential oxygen delivery systems and techniques utilized in cluster headache attacks: Background Despite oxygen therapy being one of the foremost acute treatments for cluster headache (CH) attacks, little is known about the different techniques and systems. Objectives In this review we will examine the efficacy of the standard non-rebreather mask (NRM) with room temperature oxygen in relieving pain in CH, and try to compare it with the diversity of other oxygen gas conditions and interfaces like partial rebreathers, simple masks, nasal cannulas, tusk ma... περισσότερα »

“Herbal seizures” – atypical symptoms after ibogaine intoxication

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

“Herbal seizures” – atypical symptoms after ibogaine intoxication: a case report: IntroductionMisuse of various new psychotropic substances such as ibogaine is increasing rapidly. Knowledge of their negative side effects is sparse.Case presentationWe present a case of intoxication with the herbal substance ibogaine in a 22-year-old white man. After taking a cumulative dose of 38 g (taken in two doses), he developed visual memories, nausea and vomiting. He developed a generalized tonic–clonic seizure with additional grand mal seizures. He was treated with midazolam and levetiracetam. ...περισσότερα »

Nanostructured thin film on minimally invasive surgery devices applications

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Effect of nanostructured thin film on minimally invasive surgery devices applications: characterization, cell cytotoxicity evaluation and an animal study in rat: Abstract BackgroundMinimally invasive surgery is performed using an endoscope and other instruments including the electrosurgical units. However, concerns including surgical smoke, tissue sticking and thermal injury are remaining in electrosurgery. AimsAccordingly, a newly developed electrosurgical electrode coating with hydrogenated Cu-incorporated diamond-like carbon (DLC-Cu) film is purposed to improve the instrume... περισσότερα »

Video-assisted thoracoscopic esophagectomy for squamous cell carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Impact of artificial capnothorax on coagulation in patients during video-assisted thoracoscopic esophagectomy for squamous cell carcinoma: Abstract BackgroundCompared with the lung isolation using double-lumen endobronchial tube intubation, the artificial capnothorax using single-lumen endotracheal tube intubation has shown to be a safe, more convenient, and cost-effective procedure for thoracoscopic esophagectomy. However, the impact of capnothorax on coagulation is not well defined. Herein, we evaluate the impact of a capnothorax on coagulation and fibrinolysis in patients who u... περισσότερα »

Helicobacter pylori -associated gastric carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Expressional profiles of transcription factors in the progression of Helicobacter pylori -associated gastric carcinoma based on protein/DNA array analysis: AbstractTranscription factors (TFs) are crucial modulators of gene expression during the development and progression of gastric carcinoma. *Helicobacter pylori* (*H. pylori*) is one of the most significant risk factors of gastric carcinoma, and it is widely known that chronic inflammation with *H. pylori* infection triggers gastric carcinogenesis through *inflammation*-*carcinoma chain* [gastric carcinogenesis stages: non-atroph... περισσότερα »

The influence of school time on sleep patterns of children and adolescents

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

The influence of school time on sleep patterns of children and adolescents: • Girls presented with greater sleep deficits than boys.• Predictors of sleep deficit were: social jetlag, waking time differences, and the Morningness-Eveningness Questionnaire.• The highest sleep deficit was observed among morning-shift students.• School time influences the sleep deficit in children and adolescents.

Male with a history of chronic obstructive airway disease presented to us with fever and cough

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Lucio’s phenomenon, an uncommon occurrence among leprosy patients in Sri Lanka: Background: Lucio’s phenomenon is a rare manifestation of untreated leprosy which is seen almost exclusively in regions surrounding the Gulf of Mexico. Its occurrence elsewhere though documented is considered uncommon. We present a case of Lucio’s phenomenon in a previously undiagnosed leprosy patient who presented to us with its classical skin manifestations.Case presentationA 64 year old South Asian (Sri Lankan) male with a history of chronic obstructive airway disease presented to us with fever and cou... περισσότερα »

Confirmation of endoscopically suspected esophageal metaplasia (ESEM)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Interobserver reproducibility in pathologist interpretation of columnar-lined esophagus: AbstractConfirmation of endoscopically suspected esophageal metaplasia (ESEM) requires histology, but confusion in the histological definition of columnar-lined esophagus (CLE) is a longstanding problem. The aim of this study is to evaluate interpathologist variability in the interpretation of CLE. Thirty pathologists were invited to review three ten-case sets of CLE biopsies. In the first set, the cases were provided with descriptive endoscopy only; in the second and the third sets, ESEM exten... περισσότερα »

Capturing Clinical Activity in Immuno-Oncology

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Capturing Clinical Activity in Immuno-Oncology: To evaluate antitumor responses to chemotherapeutic agents, investigators would typically rely upon Response Evaluation Criteria in Solid Tumors (RECIST) or modified WHO criteria, which do not comprehensively capture responses with immunotherapeutic agents. In the December 1, 2009, issue of *Clinical Cancer Research*, Wolchok and colleagues reported their development of novel criteria, designated "Immune-related Response Criteria" (irRC), designed to better capture the response patterns observed with immunotherapies. Broad use of the ...περισσότερα »

Hyperpolarized 13C-MRI Detects Response to Radiotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Hyperpolarized 13C-MRI Detects Response to Radiotherapy: *Purpose:* X-ray irradiation of tumors causes diverse effects on the tumor microenvironment, including metabolism. Recent developments of hyperpolarized 13C-MRI enabled detecting metabolic changes in tumors using a tracer [1-13C]pyruvate, which participates in important bioenergetic processes that are altered in cancers. Here, we investigated the effects of X-ray irradiation on pyruvate metabolism in squamous cell carcinoma (SCCVII) and colon cancer (HT-29) using hyperpolarized 13C-MRI. *Experimental Design:* SCCVII and HT-29...περισσότερα »

Autophagy, Metabolism, and Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Autophagy, Metabolism, and Cancer: Macroautophagy (autophagy hereafter) captures intracellular proteins and organelles and degrades them in lysosomes. The degradation breakdown products are released from lysosomes and recycled into metabolic and biosynthetic pathways. Basal autophagy provides protein and organelle quality control by eliminating damaged cellular components. Starvation-induced autophagy recycles intracellular components into metabolic pathways to sustain mitochondrial metabolic function and energy homeostasis. Recycling by autophagy is essential for yeast and mammals... περισσότερα »

BCL-2 Antagonism to Target Apoptosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

BCL-2 Antagonism to Target Apoptosis: Despite significant improvements in treatment, cure rates for many cancers remain suboptimal. The rise of cytotoxic chemotherapy has led to curative therapy for a subset of cancers, though intrinsic treatment resistance is difficult to predict for individual patients. The recent wave of molecularly targeted therapies has focused on druggable-activating mutations, and is thus limited to specific subsets of patients. The lessons learned from these two disparate approaches suggest the need for therapies that borrow aspects of both, targeting biolo... περισσότερα »

Targeting DGK{alpha} in Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Targeting DGK{alpha} in Cancer: Lipid kinases have largely been neglected as targets in cancer, and an increasing number of reports suggest diacylglycerol kinase alpha (DGKα) may be one with promising therapeutic potential. DGKα is one of 10 DGK family members that convert diacylglycerol (DAG) to phosphatidic acid (PA), and both DAG and PA are critical lipid second messengers in the plasma membrane. A host of important oncogenic proteins and pathways affect cancer cells in part through DGKα, including the c-Met and VEGF receptors. Others partially mediate the effects of DGKα inhibi...περισσότερα »

Hippo as a Tumor Suppressor

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Hippo as a Tumor Suppressor: The Salvador–Warts–Hippo pathway controls cell fate and tissue growth. The main function of the Hippo pathway is to prevent YAP and TAZ translocation to the nucleus where they induce the transcription of genes involved in cell proliferation, survival, and stem cell maintenance. Hippo signaling is, thus, a complex tumor suppressor, and its deregulation is a key feature in many cancers. Recent mounting evidence suggests that the overexpression of Hippo components can be useful prognostic biomarkers. Moreover, Hippo signaling appears to be intimately linke... περισσότερα »

Cell Death and Cancer Therapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Cell Death and Cancer Therapy: In our current age of targeted therapies, there is understandably considerable attention paid to the specific molecular targets of pharmaceutical intervention. For a targeted drug to work, it must bind to a target selectively and impair its function. Monitoring biomarkers of the impaired target function can provide vital *in vivo* pharmacodynamic information. Moreover, genetic changes to the target are often the source of resistance to targeted agents. However, for the treatment of cancer, it is necessary that the therapy not only provide efficient bi... περισσότερα »

Smac Mimetics as Cancer Therapeutics

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Smac Mimetics as Cancer Therapeutics: Inhibitor of Apoptosis (IAP) proteins block programmed cell death and are expressed at high levels in various human cancers, thus making them attractive targets for cancer drug development. Second mitochondrial activator of caspases (Smac) mimetics are small-molecule inhibitors that mimic Smac, an endogenous antagonist of IAP proteins. Preclinical studies have shown that Smac mimetics can directly trigger cancer cell death or, even more importantly, sensitize tumor cells for various cytotoxic therapies, including conventional chemotherapy, radi... περισσότερα »

Cytotoxic Lymphocytes, Cell Death, and Cancer Immunotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Cytotoxic Lymphocytes, Cell Death, and Cancer Immunotherapy: In the past few years, cancer immunotherapy has emerged as a safe and effective alternative for treatment of cancers that do not respond to classical treatments, including those types with high aggressiveness. New immune modulators, such as cytokines, blockers of CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) and PD-1(programmed cell death protein 1)/PD-L1 (programmed death-ligand 1), and interaction or adoptive cell therapy, have been developed and approved to treat solid and hematologic carcinomas. In these scenar... περισσότερα »

Definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer: Abstract ObjectivesThe aim of this study is to review radiotherapy (RT) techniques and outcomes for definitive RT or chemoradiotherapy (CRT) for very locally advanced or unresectable sinonasal cancer (SNC) at a single institution. MethodsBetween 1998 and 2010, there were 11 patients with very locally advanced or unresectable SNCs treated with definitive CRT (8) and RT alone (3) at the University of Utah. CRT was given to stage IVA (5)...περισσότερα »

Comprehensive genetic testing has the potential to become the standard of care for individuals with hearing loss

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Comprehensive Analysis of Deafness Genes in Families with Autosomal Recessive Nonsyndromic Hearing Loss by Tahir Atik et al. via PLOS ONE by Tahir Atik, Huseyin Onay, Ayca Aykut, Guney Bademci, Tayfun Kirazli, Mustafa Tekin, Ferda Ozkinay Comprehensive genetic testing has the potential to become the standard of care for individuals with hearing loss. In this study, we investigated the genetic etiology of autosomal recessive nonsyndromic hearing loss (ARNSHL) in a Turkish cohort including individuals with cochlear implant, who had a pedigree suggestive of an autosomal recessive inherit...περισσότερα »

Predicting the behavioral hearing threshold : Narrow band CE-Chirp auditory steady-state response is more reliable than the conventional ASSR

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Narrow band CE-Chirp auditory steady-state response is more reliable than the conventional ASSR in predicting the behavioral hearing threshold via Auris Nasus Larynx Publication date: Available online 11 November 2015 *Source:*Auris Nasus Larynx Author(s): Min Young Lee, Se Young Ahn, Hyun Ju Lee, Jae Yun Jung, Chung-Ku Rhee, Myung-Whan Suh ObjectiveWe evaluated conventional ASSR (Bio-logic MASTER II) and NB CE-Chirp ASSR thresholds as objective hearing measures in both normal and hearing loss subjects.MethodsPatients with sensorineural hearing loss and volunteer normal hearing subject... περισσότερα »

Sleep impairment in patients with chronic rhinosinusitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Risk factors for via Auris Nasus Larynx Publication date: Available online 11 November 2015 *Source:*Auris Nasus Larynx Author(s): Yuji Ando, Shintaro Chiba, Robson Capasso, Tetsushi Okushi, Hiromi Kojima, Nobuyoshi Otori, Kota Wada ObjectiveAlthough sleep impairment is reported by patients with chronic rhinosinusitis, the associated factors have not been well studied. Therefore, we determined the associated risk factors for sleep impairment in patients with chronic rhinosinusitis (CRS).MethodsThis study was a prospective cohort study. A total of 572 adult patients (171 women, 401 me... περισσότερα »

MR-Generated Synthetic CT Images for Focal Brain VMAT Radiation Therapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Assessing the Dosimetric Accuracy of Magnetic Resonance-Generated Synthetic CT Images for Focal Brain VMAT Radiation Therapy via Radiation Molecular Biology. Publication date: 1 December 2015 *Source:*International Journal of Radiation Oncology*Biology*Physics, Volume 93, Issue 5 Author(s): Eric Paradis, Yue Cao, Theodore S. Lawrence, Christina Tsien, Mary Feng, Karen Vineberg, James M. Balter PurposeThe purpose of this study was to assess the dosimetric accuracy of synthetic CT (MRCT) volumes generated from magnetic resonance imaging (MRI) data for focal brain radiation therapy.Method... περισσότερα »

Frequency and cause of readmissions following pediatric otolaryngologic surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Frequency and cause of readmissions following pediatric otolaryngologic surgery: Objectives/Hypothesis To characterize the frequency and nature of readmissions to free standing pediatric hospitals after otolaryngologic procedures. Study Design Retrospective national database analysis. Methods Using the Pediatric Health Information Systems database, we examined 30-day inpatient readmissions in children less than 18 years old who underwent otolaryngology procedures between January 1, 2009, and December 31, 2011. Univariate and multivariate logistic regression analyses accounting for c... περισσότερα »

Bilateral Mucopyocele of the Torus Tubarius

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Bilateral Mucopyocele of the Torus Tubarius: This case report describes a patient with refractory headache with incidental bilateral nasopharyngeal cysts later confirmed to be mucopyoceles. This case report describes a patient with refractory headache with incidental bilateral nasopharyngeal cysts later confirmed to be mucopyoceles. Cystic lesions of the nasopharynx are typically asymptomatic and are often discovered incidentally with imaging or endoscopic examination. The etiology of these lesions can be either congenital or acquired. Acquired lesions, such as mucoceles, salivar... περισσότερα »

Dysphagia Following Airway Reconstruction in Adults

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Dysphagia Following Airway Reconstruction in Adults: In this review of the medical records of adults who underwent open airway reconstruction, all patients returned to preoperative diet, but those without stents had shorter duration of dysphagia symptoms than those with stents. *Importance* Patients who undergo open airway reconstruction procedures are likely to experience some degree of postoperative dysphagia symptoms and delayed return to oral intake. *Objective* To review the duration of postoperative dysphagia symptoms and outcomes in a group of adult patients. *Design, Setti... περισσότερα »

Incidence of Suicide in Patients With Head and Neck Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Incidence of Suicide in Patients With Head and Neck Cancer: This cohort study of SEER data found that patients with head and neck cancer have more than 3 times the incidence of suicide compared with the general US population and that patients with hypopharyngeal and laryngeal cancer are at highest risk. *Importance* Suicide rates among patients with cancer in the US are significantly higher than those of the general population. To our knowledge, large cohort studies examining suicide rates among patients with head and neck cancer have not been performed. *Objective* To identify...περισσότερα »

Thyroidectomy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Surgeon Volume and Outcomes and Cost Savings Following Thyroidectomy: In this cross-sectional analysis of Nationwide Inpatient Sample thyroidectomy data, procedures performed by higher-volume surgeons were associated with fewer complications and lower cost. *Importance* Incidence of thyroidectomies is continuing to increase. Identifying factors associated with favorable outcomes can lead to cost savings. *Objective* To assess the association of surgeon volume with clinical outcomes and costs of thyroidectomy. *Design, Setting, and Participants* Cross-sectional analysis performe...περισσότερα »

The Evaluation of the Diagnostic Properties of Intra-operative In-situ Thyroglobin Levels of Cervical Lymph Nodes, in the Discrimination Between Benign and Malignant Lymph Nodes in Thyroid Cancer: a Prospective Multicentre Study.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

The Evaluation of the Diagnostic Properties of Intra-operative In-situ Thyroglobin Levels of Cervical Lymph Nodes, in the Discrimination Between Benign and Malignant Lymph Nodes in Thyroid Cancer: a Prospective Multicentre Study.: *Condition*: Thyroid Cancer *Intervention*: Other: lymph nodes cyto-punction *Sponsor*: Assistance Publique Hopitaux De Marseille *Recruiting* - verified October 2015 Cytological examination of punctured lymph nodes is the gold standard for confirming metastatic lymph node spread of differentiated thyroid cancers. In order to increase the diagnosti... περισσότερα »

Different Cycles of Capecitabine Usage in Esophageal Cancer Concurrent Chemoradiotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Different Cycles of Capecitabine Usage in Esophageal Cancer Concurrent Chemoradiotherapy: *Conditions*: Stage III Esophageal Squamous Cell Carcinoma; Stage II Esophageal Squamous Cell Carcinoma *Interventions*: Drug: Capecitabine(Aibin); Radiation: radiotherapy *Sponsor*: The First Affiliated Hospital of Henan University of Science and Technology Definitive chemoradiotherapy with cisplatin with cisplatin plus 5-fluorouracil is the standard in Western countries in esophagus cancer.But in China because of its toxic reaction, most of patients stop the halfway.Because low ...περισσότερα »

Evaluation of a BICROS System with a Directional Microphone in the Receiver and Transmitter.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα

Related Articles *Evaluation of a BICROS System with a Directional Microphone in the Receiver and Transmitter.* J Am Acad Audiol. 2015 Nov-Dec;26(10):856-71 Authors: Valente M, Oeding K Abstract BACKGROUND: The bilateral contralateral routing of signals (BICROS) system has provided limited benefit for speech recognition in noise for patients with asymmetric sensorineural hearing loss, even when an automatic adaptive multichannel directional microphone (DM) is in the receiver (Rx) and an omnidirectional microphone (OM) is in the transmitter (Tx). A recent BICROS system was introd...περισσότερα »

Benefits of Nonlinear Frequency Compression in Adult Hearing Aid Users.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα

Related Articles *Benefits of Nonlinear Frequency Compression in Adult Hearing Aid Users.* J Am Acad Audiol. 2015 Nov-Dec;26(10):838-55 Authors: Kokx-Ryan M, Cohen J, Cord MT, Walden TC, Makashay MJ, Sheffield BM, Brungart DS Abstract BACKGROUND: Frequency-lowering (FL) algorithms are an alternative method of providing access to high-frequency speech cues. There is currently a lack of independent research addressing: (1) what functional, measureable benefits FL provides; (2) which, if any, FL algorithm provides the maximum benefit, (3) how to clinically program algorithms, and (4... περισσότερα »

What Can We Learn about Auditory Processing from Adult Hearing Questionnaires?

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα

Related Articles *What Can We Learn about Auditory Processing from Adult Hearing Questionnaires?* J Am Acad Audiol. 2015 Nov-Dec;26(10):824-37 Authors: Bamiou DE, Iliadou VV, Zanchetta S, Spyridakou C Abstract BACKGROUND: Questionnaires addressing auditory disability may identify and quantify specific symptoms in adult patients with listening difficulties. PURPOSE: (1) To assess validity of the Speech, Spatial, and Qualities of Hearing Scale (SSQ), the (Modified) Amsterdam Inventory for Auditory Disability (mAIAD), and the Hyperacusis Questionnaire (HYP) in adult patients experie...περισσότερα »

Perception of Hearing Aid-Processed Speech in Individuals with Late-Onset Auditory Neuropathy Spectrum Disorder.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα

Related Articles *Perception of Hearing Aid-Processed Speech in Individuals with Late-Onset Auditory Neuropathy Spectrum Disorder.* J Am Acad Audiol. 2015 Nov-Dec;26(10):815-23 Authors: Mathai JP, Appu S Abstract BACKGROUND: Auditory neuropathy spectrum disorder (ANSD) is a form of sensorineural hearing loss, causing severe deficits in speech perception. The perceptual problems of individuals with ANSD were attributed to their temporal processing impairment rather than to reduced audibility. This rendered their rehabilitation difficult using hearing aids. Although hearing aids c... περισσότερα »

Refining Stimulus Parameters in Assessing Infant Speech Perception Using Visual Reinforcement Infant Speech Discrimination: Sensation Level.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα

Related Articles *Refining Stimulus Parameters in Assessing Infant Speech Perception Using Visual Reinforcement Infant Speech Discrimination: Sensation Level.* J Am Acad Audiol. 2015 Nov-Dec;26(10):807-14 Authors: Uhler KM, Baca R, Dudas E, Fredrickson T Abstract BACKGROUND: Speech perception measures have long been considered an integral piece of the audiological assessment battery. Currently, a prelinguistic, standardized measure of speech perception is missing in the clinical assessment battery for infants and young toddlers. Such a measure would allow systematic assessment of... περισσότερα »

Easy Access to Hearing Health Care: Are We Closer Than We Think?

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα

Related Articles *Easy Access to Hearing Health Care: Are We Closer Than We Think?* J Am Acad Audiol. 2015 Nov-Dec;26(10):806 Authors: McCaslin DL PMID: 26554485 [PubMed - in process] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1WV5gzJ via IFTTT

Rehabilitation

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα

Imaging Predictors of Improvement From a Motor Learning-Based Intervention for Children With Unilateral Cerebral Palsy *Background*. Motor-learning interventions may improve hand function in children with unilateral cerebral palsy (UCP) but with inconsistent outcomes across participants. *Objective*. To examine if pre-intervention brain imaging predicts benefit from bimanual intervention. *Method*. Twenty children with UCP with Manual Ability Classification System levels I to III, aged 7-16 years, participated in an intensive bimanual intervention. Assessments included the Assisting ... περισσότερα »

Residence deprivation in a cohort of oral cancer patients

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Outcomes by area of residence deprivation in a cohort of oral cancer patients: Survival, health-related quality of life, and place of death via ScienceDirect Publication: Oral Oncology Publication date: Available online 12 November 2015 *Source:*Oral Oncology Author(s): Joseph Rylands, Derek Lowe, Simon N. Rogers ObjectivesOral cancer patients from lower socio-economic backgrounds have worse outcomes of survival and health related quality of life. The mechanism of cause is not fully understood. The purpose of the paper is to report treatment selection, survival, health related quality o...περισσότερα »

Video-otoscopy in children and patient-centered care

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Video-otoscopy in children and patient-centered care: A randomized, controlled study.: Medicine today is moving towards patient centered care and patient empowerment. This enhances patient autonomy, allows shared decision making and increases satisfaction. Current technology enables the caregiver to share visual data with the patients, making them more active participants in a medical encounter. It has been shown that higher patient satisfaction rate has a positive effect on outcome and patient compliance. Otoscopic examination is one of the most common procedures performed in the p...περισσότερα »

Thyroid Cancer and Nonsteroidal Anti-Inflammatory Drug Use

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Thyroid Cancer and Nonsteroidal Anti-Inflammatory Drug Use: A Pooled Analysis of Patients Older Than 40 Years of Age: Thyroid , Vol. 0, No. 0. Author information Dhaval Patel,1 Cari M. Kitahara,2 Yikyung Park,3,4 Linda M. Liao,4 Martha Linet,4 Electron Kebebew,1and Naris Nilubol1 1Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 2Division of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 3Division of Public Health Sciences, Washingt...περισσότερα »

hiperplasia de amigdalas palatinas

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

hiperplasia de amigdalas palatinas: hiperplasia de amigdalas palatinas

Histiocitose

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Histiocitose: Histiocitose

Lesão por arma de fogo ponta mastóide 1

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Lesão por arma de fogo ponta mastóide 1: Lesão por arma de fogo ponta mastóide 1

malformação com perfuração timpânica OE

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

malformação com perfuração timpânica OE: malformação com perfuração timpânica OE

Otoespongiose

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Otoespongiose: Otoespongiose