A community research model developed in the United Kingdom was adopted in a multi-country study of health in diverse neighbourhoods in European cities, including Sweden. This paper describes the challenges and...
https://ift.tt/2oaV261
Σάββατο 25 Αυγούστου 2018
Researching health in diverse neighbourhoods: critical reflection on the use of a community research model in Uppsala, Sweden
Below normal birth weight in the Northwest part of Ethiopia
Low birth weight is one of the global agendas that have an impact on the short and long-term health status. A cross-sectional study from March 1 to April 1, 2018 was conducted. 381 mother–newborn pairs were pa...
https://ift.tt/2BNMawT
Intestinal parasitosis among HIV/AIDS patients who are on anti-retroviral therapy in Kombolcha, North Central, Ethiopia: a cross-sectional study
Human immunodeficiency virus (HIV) infected patients are highly vulnerable to microbial and parasitic diseases due to the immune-suppression. This study aimed to determine the prevalence and assess the associa...
https://ift.tt/2oaTBV6
Memantine has no effect on KATP channels in pancreatic β cells
Memantine, a drug for Alzheimer's disease, is considered to suppress excessive stimulation of N-methyl-d-aspartic acid receptors and to prevent neuronal death. However, a recent report indicated that the neuronal...
https://ift.tt/2BOj5kW
How did cyanobacteria first embark on the path to becoming plastids?: Lessons from protist symbioses
Abstract
Symbioses between phototrophs and heterotrophs (a.k.a 'photosymbioses') are extremely common, and range from loose and temporary associations to obligate and highly specialized forms. In the history of life, the most transformative was the 'primary endosymbiosis,' wherein a cyanobacterium was engulfed by a eukaryote and became genetically integrated as a heritable photosynthetic organelle, or plastid. By allowing the rise of algae and plants, this event dramatically altered the biosphere, but its remote origin over one billion years ago has obscured the sequence of events leading to its establishment. Here we review the genetic, physiological, and developmental hurdles involved in early primary endosymbiosis. Since we cannot travel back in time to witness these evolutionary junctures, we will draw on examples of unicellular eukaryotes (protists) spanning diverse modes of photosymbiosis. We also review experimental approaches that could be used to recreate aspects of early primary endosymbiosis on a human timescale.https://ift.tt/2wbgz36
Steep redox gradient and biogeochemical cycling driven by deeply sourced fluids and gases in a terrestrial mud volcano
Abstract
Mud volcanoes provide an accessible channel through which deep subsurface environments can be observed. The manner in which deeply sourced materials shape biogeochemical processes and microbial communities in such geological features remains largely unknown. This study characterized redox transitions, biogeochemical fluxes, and microbial communities for samples collected from a methane-rich mud volcano in southwestern Taiwan. Our results indicated that oxygen penetration was confined within the upper 4 mm of fluids/muds and counteracted by the oxidation of pyrite, dissolved sulfide, methane, and organic matter at various degrees. Beneath the oxic zone, anaerobic sulfur oxidation, sulfate reduction, anaerobic methanotrophy, and methanogenesis were compartmentalized into different depths in the pool periphery, forming a metabolic network that efficiently cycles methane and sulfur. Community members affiliated with various Proteobacteria capable of aerobic oxidation of sulfur, methane, and methyl compounds were more abundant in the anoxic zone with diminished sulfate and high methane. These findings suggest either the requirement of alternative electron acceptors or a persistent population that once flourished in the oxic zone. Overall, this study demonstrates the distribution pattern for a suite of oxidative and reductive metabolic reactions along a steep redox gradient imposed by deep fluids in a mud volcano ecosystem.https://ift.tt/2MBzm1O
A potential central role of Thaumarchaeota in N-Cycling in a Semi-Arid environment, Fort Stanton Cave, Snowy River passage, New Mexico, USA
Abstract
Low biomass and productivity of arid-land caves with limited availability of nitrogen (N) raises the question of how microbes acquire and cycle this essential element. Caves are ideal environments for investigating microbial functional capabilities, as they lack phototrophic activity and have near constant temperatures and high relative humidity. From the walls of Fort Stanton Cave (FSC), multicolored secondary mineral deposits of soil-like material low in fixed N, known as ferromanganese deposits (FMD), were collected. We hypothesized that within FMD samples we would find the presence of microbial N cycling genes and taxonomy related to N cycling microorganisms. Community DNA were sequenced using Illumina shotgun metagenomics and 16S rRNA gene sequencing. Results suggest a diverse N cycle encompassing several energetic pathways including nitrification, dissimilatory nitrate reduction, and denitrification. N cycling genes associated with assimilatory nitrate reduction were also identified. Functional gene sequences and taxonomic findings suggest several bacterial and archaeal phyla potentially play a role in nitrification pathways in FSC FMD. Thaumarchaeota, a deep-branching archaeal division, likely play an essential and possibly dominant role in the oxidation of ammonia. Our results provide genomic evidence for understanding how microbes are potentially able to acquire and cycle N in a low-nutrient subterranean environment.https://ift.tt/2P6pVnB
Antioxidant and Anticancer Roles of a Novel Strain of Bacillus anthracis Isolated from Vermicompost Prepared from Paper Mill Sludge
Mass production of vermicompost using suitable species of earthworms and selecting target organic waste materials has appeared to be a great development in the realm of biotechnological research for the sustainable eco-management. Although, for the bioconversion of organic wastes to vermicompost, suitable earthworm species play major roles, a hoard of bacterial assemblages by virtue of production of different enzymes facilitate the process of vermicomposting. The present study has documented the roles of vermicompost associated bacteria in combating, preventing, and controlling of cancer so as to open a new vista not only in the field of vermitechnology but also on biomedical research. Earthworms' associated bacterial metabolic products having their unique physicochemical excellence have gained importance due to their roles as a facilitator of apoptosis (programed cell death in a MCF-7 cell line). The antioxidant and anticancer activities of ethyl acetate extracts' of vermicompost associated bacterium Bacillus anthracis were undertaken by antioxidant assay which revealed maximum DPPH radical scavenging effect (75.79 ± 5.41%) of the extracts' at 9 00 μg ml-1. Furthermore, the crude extracts obtained from the same bacteria were found to decrease the activity of SOD (superoxide dismutase) with the increase in doses. MTT assay showed potent cytotoxic activity against human breast adenocarcinoma cells (MCF-7) with the IC50 value of 46.64 ± 0.79 μg ml-1. It was further confirmed through Hoechst 33258 staining of nuclear fragmentation assay and DNA fragmentation analysis. Western blotting test has confirmed a downregulation of Akt upon application of crude extracts. Increase of SOD activity along with decrease of Akt level reflects that the mode of action is entirely PI-3K dependent. This study tends to indicate that B. anthracis isolated from vermicompost could be potentially explored for the development of new therapeutic agents, especially against cancer.
https://ift.tt/2BMAlqJ
Most Research Participants Not Concerned About Data Sharing
MONDAY, Aug. 25, 2018 -- Few participants in clinical trials have strong concerns about the risks of data sharing, according to a study published June 7 in the New England Journal of Medicine. Michelle M. Mello, J.D., Ph.D., from Stanford University...
https://ift.tt/2P6EQhv
Characterization of the symptoms of neurogenic orthostatic hypotension and their impact from a survey of patients and caregivers
Neurogenic orthostatic hypotension (nOH) results from impaired vasoconstriction due to dysfunction of the autonomic nervous system and is commonly associated with Parkinson disease (PD), multiple system atroph...
https://ift.tt/2Lp3PdH
Fusing multi-scale information in convolution network for MR image super-resolution reconstruction
Magnetic resonance (MR) images are usually limited by low spatial resolution, which leads to errors in post-processing procedures. Recently, learning-based super-resolution methods, such as sparse coding and s...
https://ift.tt/2BTOXo6
Not again! Effect of previous test results, age group and reason for testing on (re-)infection with Chlamydia trachomatis in Germany
Infection with Chlamydia trachomatis (Ct) is the most commonly reported sexually transmitted infection in Europe. In Germany, Ct screening is offered free of charge to pregnant women since 1995 and to women
https://ift.tt/2P2bAsi
The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders
The importance of gut microbiota in gastrointestinal (GI) physiology was well described, but our ability to study gut microbial ecosystems in their entirety was limited by culture-based methods prior to the sequencing revolution. The advent of high-throughput sequencing opened new avenues, allowing us to study gut microbial communities as an aggregate, independent of our ability to culture individual microbes. Early studies focused on association of changes in gut microbiota with different disease states which was necessary to identify a potential role for microbes and generate novel hypotheses.
https://ift.tt/2BJrmqe
Cerebrospinal Fluid Hyaluronan and Neurofibromatosis Type 2
Abstract
Neurofibromatosis type 2 (NF-2) is associated with mainly three types of recurrent benign tumors restricted to the central nervous system: schwannoma, meningioma and ependymoma. The absence of the protein NF2/Merlin causes an uninterrupted cell proliferation cascade originating from an abnormal interaction between an extracellular mucopolysaccharide, hyaluronan (HA), and schwann cell surface CD44 receptor, which has been identified as one of the central causative factors for schwannoma. Most tumors in NF-2 have a predilection to originate from either arachnoid cap cells or schwann cells of the cisternal portion of nerve rootlets that share a continuous exposure to cerebrospinal fluid (CSF). We hypothesize that the CSF HA may play a role in tumorigenesis in NF-2. In a prospective analysis over a period of one year, the levels of medium to low molecular weight HA (LMW HA) was estimated in the CSF of three subjects with central schwannomas and compared against that of age-sex matched controls, using Cetyltrimethylammonium bromide coupled turbidimetric assay and found to be seventeen-fold higher in the schwannoma subjects compared to the controls. HA was observed to be actively secreted by cultured schwannoma cells isolated from tumor tissues commensurate with their proliferation rate. On cell viability index analysis to compare the cell proliferation of astrocytoma cells with LMW HA vs. oligomeric HA (OHA), we found a decrease in cell proliferation of up to 30% with OHA. The study provides initial evidence that CSF HA may have a central role in the tumorigenesis of schwannoma in NF-2.
https://ift.tt/2MNMtMl
Analysis of Epididymal Protein Synthesis and Secretion
https://ift.tt/2NkO35l
The Swapping Constraint
Abstract
Triviality arguments against the computational theory of mind claim that computational implementation is trivial and thus does not serve as an adequate metaphysical basis for mental states. It is common to take computational implementation to consist in a mapping from physical states to abstract computational states. In this paper, I propose a novel constraint on the kinds of physical states that can implement computational states, which helps to specify what it is for two physical states to non-trivially implement the same computational state.
https://ift.tt/2LsZPJk
The Role of Observers in Computations
Abstract
John Searle raised the question whether all computation is observer-relative. Indeed, all of the common views of computation, be they semantical, functional or causal rely on mapping something onto the states of a physical or abstract process. In order to effectively execute such a mapping, this process would have to be observed in some way. Thus a probably syntactical analysis by an observer seems to be essential for judging whether a given process implements some computation or not. In order to be able to explore the nature of these observers in a more formal way, we look at the Computing by Observing paradigm, a theoretical model of computation that includes an observer. We argue that the observers used there, monadic transducers, are good candidates for formalizing the way in which the syntax of a process must be analysed in order to judge whether it is computational.
https://ift.tt/2obXRUA
Tick Microbiome Characterization by Next-Generation 16S rRNA Amplicon Sequencing
Here we present a next-generation sequencing protocol for 16S rRNA sequencing which enables identification and characterization of microbial communities within vectors. This method involves DNA extraction, amplification and barcoding of samples through PCR, sequencing on a flow-cell, and bioinformatics to match sequence data to phylogenetic information.
https://ift.tt/2PDNS71
Endogenous Protein Tagging in Human Induced Pluripotent Stem Cells Using CRISPR/Cas9
Described here is a protocol for tagging endogenously expressed proteins with fluorescent tags in human induced pluripotent stem cells using CRISPR/Cas9. Putatively edited cells are enriched by fluorescence activated cell sorting and clonal cell lines are generated.
https://ift.tt/2NiwPpl
Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
Electronic cigarette (e-cig) users are increasing worldwide. Little, however, is known about the health effects induced by inhaled e-cig aerosols. This article describes an e-cig aerosol generation technique suitable for animal exposures and subsequent toxicological studies. Such protocols are required to establish experimentally reproducible and standardized e-cig exposure systems.
https://ift.tt/2PDNIfV
A Flexible Low Cost Hydroponic System for Assessing Plant Responses to Small Molecules in Sterile Conditions
https://ift.tt/2P7dDvf
A Simplified and Efficient Method to Isolate Primary Human Keratinocytes from Adult Skin Tissue
Here we present a protocol to efficiently isolate primary human keratinocytes from adult skin tissues. This method simplifies the conventional procedure by using the ROCK Inhibitor Y-27632 in the inoculation medium to spontaneously separate epidermal cells from dermal cells.
https://ift.tt/2Px9x0B
Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy
Abstract
Hypoxic-ischaemic encephalopathy remains a global health burden. Despite medical advances and treatment with therapeutic hypothermia, over 50% of cooled infants are not protected and still develop lifelong neurodisabilities, including cerebral palsy. Furthermore, hypothermia is not used in preterm cases or low resource settings. Alternatives or adjunct therapies are urgently needed. Exendin-4 is a drug used to treat type 2 diabetes mellitus that has also demonstrated neuroprotective properties, and is currently being tested in clinical trials for Alzheimer's and Parkinson's diseases. Therefore, we hypothesized a neuroprotective effect for exendin-4 in neonatal neurodisorders, particularly in the treatment of neonatal hypoxic-ischaemic encephalopathy. Initially, we confirmed that the glucagon like peptide 1 receptor (GLP1R) was expressed in the human neonatal brain and in murine neurons at postnatal Day 7 (human equivalent late preterm) and postnatal Day 10 (term). Using a well characterized mouse model of neonatal hypoxic-ischaemic brain injury, we investigated the potential neuroprotective effect of exendin-4 in both postnatal Day 7 and 10 mice. An optimal exendin-4 treatment dosing regimen was identified, where four high doses (0.5 µg/g) starting at 0 h, then at 12 h, 24 h and 36 h after postnatal Day 7 hypoxic-ischaemic insult resulted in significant brain neuroprotection. Furthermore, neuroprotection was sustained even when treatment using exendin-4 was delayed by 2 h post hypoxic-ischaemic brain injury. This protective effect was observed in various histopathological markers: tissue infarction, cell death, astrogliosis, microglial and endothelial activation. Blood glucose levels were not altered by high dose exendin-4 administration when compared to controls. Exendin-4 administration did not result in adverse organ histopathology (haematoxylin and eosin) or inflammation (CD68). Despite initial reduced weight gain, animals restored weight gain following end of treatment. Overall high dose exendin-4 administration was well tolerated. To mimic the clinical scenario, postnatal Day 10 mice underwent exendin-4 and therapeutic hypothermia treatment, either alone or in combination, and brain tissue loss was assessed after 1 week. Exendin-4 treatment resulted in significant neuroprotection alone, and enhanced the cerebroprotective effect of therapeutic hypothermia. In summary, the safety and tolerance of high dose exendin-4 administrations, combined with its neuroprotective effect alone or in conjunction with clinically relevant hypothermia make the repurposing of exendin-4 for the treatment of neonatal hypoxic-ischaemic encephalopathy particularly promising.https://ift.tt/2Lor9s1
Parkinsonian signs in patients with cervical dystonia treated with pallidal deep brain stimulation
Abstract
Pallidal deep brain stimulation is an established treatment in patients with dystonia. However, evidence from case series or uncontrolled studies suggests that it may lead in some patients to specific parkinsonian symptoms such as freezing of gait, micrographia, and bradykinesia. We investigated parkinsonian signs using the Movement Disorder Society Unified Parkinson's Disease Rating Scale motor score by means of observer-blinded video ratings in a group of 29 patients treated with pallidal stimulation and a non-surgical control group of 22 patients, both with predominant cervical dystonia. Additional assessments included MRI-based models of volume of neural tissue activated to investigate areas of stimulation related to dystonic symptom control and those likely to induce parkinsonian signs as well as an EMG analysis to investigate functional vicinity of stimulation fields to the pyramidal tract. Compared with controls, stimulated patients had significantly higher motor scores (median, 25th–75th percentile: 14.0, 8.0–19.5 versus 3.0, 2.0–8.0; P < 0.0001), as well as bradykinesia (8.0, 6.0–14.0 versus 2.0, 0.0–3.0; P < 0.0001) and axial motor subscores (2.0, 1.0–4.0 versus 0.0, 0.0–1.0; P = 0.0002), while rigidity and tremor subscores were not different between groups. Parkinsonian signs were partially reversible upon switching stimulation off for a median of 90 min in a subset of 19 patients tolerating this condition. Furthermore, the stimulation group reported more features of freezing of gait on a questionnaire basis. Quality of life was better in stimulated patients compared with control patients, but parkinsonian signs were negatively associated with quality of life. In the descriptive imaging analysis maximum efficacy for dystonia improvement projected to the posteroventrolateral internal pallidum with overlapping clusters driving severity of bradykinesia and axial motor symptoms. The severities of parkinsonian signs were not correlated with functional vicinity to the pyramidal tract as assessed by EMG. In conclusion, parkinsonian signs, particularly bradykinesia and axial motor signs, due to pallidal stimulation in dystonic patients are frequent and negatively impact on motor functioning and quality of life. Therefore, patients with pallidal stimulation should be monitored closely for such signs both in clinical routine and future clinical trials. Spread of current outside the internal pallidum is an unlikely explanation for this phenomenon, which seems to be caused by stimulation of neural elements within the stimulation target volume.https://ift.tt/2PA64y6
Balance control systems in Parkinson’s disease and the impact of pedunculopontine area stimulation
Abstract
Impaired balance is a major contributor to falls and diminished quality of life in Parkinson's disease, yet the pathophysiology is poorly understood. Here, we assessed if patients with Parkinson's disease and severe clinical balance impairment have deficits in the intermittent and continuous control systems proposed to maintain upright stance, and furthermore, whether such deficits are potentially reversible, with the experimental therapy of pedunculopontine nucleus deep brain stimulation. Two subject groups were assessed: (i) 13 patients with Parkinson's disease and severe clinical balance impairment, implanted with pedunculopontine nucleus deep brain stimulators; and (ii) 13 healthy control subjects. Patients were assessed in the OFF medication state and blinded to two conditions; off and on pedunculopontine nucleus stimulation. Postural sway data (deviations in centre of pressure) were collected during quiet stance using posturography. Intermittent control of sway was assessed by calculating the frequency of intermittent switching behaviour (discontinuities), derived using a wavelet-based transformation of the sway time series. Continuous control of sway was assessed with a proportional–integral–derivative (PID) controller model using ballistic reaction time as a measure of feedback delay. Clinical balance impairment was assessed using the 'pull test' to rate postural reflexes and by rating attempts to arise from sitting to standing. Patients with Parkinson's disease demonstrated reduced intermittent switching of postural sway compared with healthy controls. Patients also had abnormal feedback gains in postural sway according to the PID model. Pedunculopontine nucleus stimulation improved intermittent switching of postural sway, feedback gains in the PID model and clinical balance impairment. Clinical balance impairment correlated with intermittent switching of postural sway (rho = − 0.705, P < 0.001) and feedback gains in the PID model (rho = 0.619, P = 0.011). These results suggest that dysfunctional intermittent and continuous control systems may contribute to the pathophysiology of clinical balance impairment in Parkinson's disease. Clinical balance impairment and their related control system deficits are potentially reversible, as demonstrated by their improvement with pedunculopontine nucleus deep brain stimulation.https://ift.tt/2Lor1Zz
Organotypic Culture Method to Study the Development Of Embryonic Chicken Tissues
Here, we present an organotypic culturing protocol to grow embryonic chicken organs in vitro. Using this method, the development of embryonic chicken tissue can be studied, while maintaining a high degree of control over the culture environment.
https://ift.tt/2obHg38
EMCrit 231 – How to Practice Cricothyroidotomy (Cric)
How to use the cric models and optimal surgical airway technique.
EMCrit Project by Scott Weingart.
https://ift.tt/2MMRxAM
Measuring Biodiversity and Extinction – Present and Past
Abstract
How biodiversity is changing in our time represents a major concern for all organismal biologists. Anthropogenic changes to our planet are decreasing species diversity through the negative effects of pollution, habitat destruction, direct extirpation of species, and climate change. But major biotic changes – including those that have both increased and decreased species diversity – have happened before in Earth's history. Biodiversity dynamics in past eras provide important context to understand ecological responses to current environmental change. The work of assessing biodiversity is woven into ecology, environmental science, conservation, paleontology, phylogenetics, evolutionary and developmental biology, and many other disciplines; yet, the absolute foundation of how we measure species diversity depends on taxonomy and systematics. The aspiration of this symposium, and complementary contributed talks, was to promote better understanding of our common goals and encourage future interdisciplinary discussion of biodiversity dynamics. The contributions in this collection of papers bring together a diverse group of speakers to confront several important themes. How can biologists best respond to the urgent need to identify and conserve diversity? How can we better communicate the nature of species across scientific disciplines? Where are the major gaps in knowledge about the diversity of living animal and plant groups, and what are the implications for understanding potential diversity loss? How can we effectively use the fossil record of past diversity and extinction to understand current biodiversity loss?https://ift.tt/2Lpx3ta
Predictors of a successful external cephalic version: A population-based study of Washington state births
Publication date: Available online 24 August 2018
Source: Women and Birth
Author(s): Erin R. Morgan, Audrey E. Hu, Audrey M.V. Brezak, Seth S. Rowley, Alyson J. Littman, Stephen E. Hawes
Abstract
Background
Breech presentation affects approximately 3% of women with singleton pregnancies. External cephalic version is a manual procedure that reorients a foetus to cephalic position in preparation for birth, reducing indications for caesarean birth. However, unsuccessful attempts are associated with some adverse health outcomes. Versions are successful in 17–86% of attempts. Temporal trends in version success and association between maternal height or prenatal care and version success are unknown. Few population-based studies and no recent investigations in the United States have evaluated predictive factors for version success.
Objectives
This study aimed to estimate the proportion of successful version procedures in the United States and to evaluate factors associated with version success.
Methods
We used birth certificate and hospital administrative data. The study included all women who had a singleton birth in Washington State between 2003–2014 following a version procedure (total n = 4981). Prevalence ratios and 95% confidence intervals were calculated using Poisson regression.
Findings
57.2% of version attempts were successful. Primiparity (Prevalence Ratio:1.43; 95% Confidence Interval:1.29–1.60) and multiparity (Prevalence Ratio:1.68; 95% Confidence Interval:1.50–1.88) were associated with procedure success. Oligohydramnios was associated with lower version success (Prevalence Ratio:0.75; 95% Confidence Interval:0.57–1.00). Maternal height, pre-pregnancy weight, polyhydramnios, frequency of prenatal care, smoking, infant sex, and year of birth were not significantly associated with version outcome.
Conclusion
We found that most version procedures are successful. This reinforces that procedures may be able to reduce the frequency of caesarean birth. These contemporary results can help women and clinicians make decisions with realistic estimates of success.
https://ift.tt/2NiMk0w
A cross-country survey of attitudes toward childbirth technologies and interventions among university students
Publication date: Available online 24 August 2018
Source: Women and Birth
Author(s): Kathrin Stoll, Joyce Edmonds, Michelle Sadler, Gill Thomson, Judith McAra-Couper, Emma M. Swift, Anne Malott, Joana Streffing, Mechthild M. Gross, Soo Downe, the ICAPP Study Team
Abstract
Problem & aim
Cultural beliefs that equate birth technology with progress, safety and convenience contribute to widespread acceptance of childbirth technology and interventions.
Little is known about attitudes towards childbirth technology and interventions among the next generation of maternity care users and whether attitudes vary by country, age, gender, childbirth fear, and other factors.
Methods
Data were collected via online survey in eight countries. Students who had never had children, and who planned to have at least one child were eligible to participate.
Findings
The majority of participants (n = 4569) were women (79.3%), and the median age was 22 years. More than half of students agreed that birth technology makes birth easier (55.8%), protects babies from harm (49.1%) and that women have a right to choose a medically non-indicated cesarean (50.8%). Respondents who had greater acceptance of childbirth technology and interventions were from countries with higher national caesarean birth rates, reported higher levels of childbirth fear, and were more likely to report that visual media or school-based education shaped their attitudes toward birth. Positive attitudes toward childbirth technology and interventions were also associated with less confidence in knowledge of birth, and more common among younger and male respondents.
Discussion/conclusion
Educational strategies to teach university students about pregnancy and birth in ways that does not frighten them and promotes critical reflection about childbirth technology are needed. This is especially true in countries with high rates of interventions that reciprocally shape culture norms, attitudes, and expectations.
https://ift.tt/2wf9LRT
What attributes do Australian midwifery leaders identify as essential to effectively manage a Midwifery Group Practice?
Publication date: Available online 24 August 2018
Source: Women and Birth
Author(s): Leonie Hewitt, Holly Priddis, Hannah G. Dahlen
Abstract
Background
Despite well-known benefits of continuity of midwifery care, less than 10% of women have access to this model of care in Australia. Staff retention and satisfaction are strongly related to the quality of management; however, little is known about the attributes required to effectively manage a midwifery group practice.
Purpose
To explore the attributes midwifery group practice managers require to be effective managers and how these attributes can be developed to promote service sustainability.
Methods
A qualitative interpretive approach, employing in-depth interviews with eight midwifery leaders was undertaken and analysed using thematic analysis.
Results
The overarching theme described the ideal midwifery group practice manager as someone who stands up for midwives and women and is 'Holding the ground for midwifery, for women'. Subthemes demonstrate midwifery group practice management is complex: 'having it', describes the intrinsic traits of an effective leader; 'someone with their hand on the steering wheel' illustrates the day to day job of being a manager and the role of 'juggling the forces' that surround group practice; 'helping managers to manage better' explored the need for managers to be educated and supported for the role.
Conclusions
Managers require certain attributes to effectively manage these unique services, whilst also juggling the needs of the organisation as a whole. Having transformational leadership qualities with vision to lead the practice into the future are key. There needs to be better support and preparation for the role if midwifery group practice is to be a sustainable option for women and midwives.
https://ift.tt/2Lsb1FU
One-Year Outcomes after PCI Strategies in Cardiogenic Shock
Early revascularization has been shown to reduce mortality among patients with acute myocardial infarction that is complicated by cardiogenic shock. Most patients with cardiogenic shock present with multivessel coronary artery disease, which is associated with higher mortality than single-vessel…
https://ift.tt/2PDSERU
Crystallizing Galactocele: A rare entity—report of two cases
Diagnostic Cytopathology, EarlyView.
https://ift.tt/2BI6vU8
Role of FNAC in diagnosing lesions of hand and wrist
Diagnostic Cytopathology, EarlyView.
https://ift.tt/2oaYWfi
Novel cytomorphologic characteristics suggesting human papillomavirus infection in patients diagnosed as negative for intraepithelial lesion or malignancy and a comparison of diagnostic performance of three human papillomavirus tests
Diagnostic Cytopathology, EarlyView.
https://ift.tt/2NhVTwA
Cytologic diagnosis of adenocarcinoma on bile duct brushings in the presence of stent associated changes: A retrospective analysis
Diagnostic Cytopathology, EarlyView.
https://ift.tt/2wcz5I7
Parotid gland chondroma masquerading as pleomorphic adenoma in fine needle aspiration cytology: A diagnostic challenge
Diagnostic Cytopathology, EarlyView.
https://ift.tt/2BLpc9t
Low Back Pain in Persons with Lower Extremity Amputation: A Systematic Review of the Literature
Publication date: Available online 24 August 2018
Source: The Spine Journal
Author(s): M. Jason Highsmith, Lisa M. Goff, Amanda L. Lewandowski, Shawn Farrokhi, Brad D. Hendershot, Owen T. Hill, Christopher A. Rábago, Elizabeth Russell-Esposito, John J. Orriola, John M. Mayer
ABSTRACT
Background Context
Lower extremity amputation (LEA) is associated with elevated risk for development and progression of secondary health conditions. Low back pain (LBP) is one such condition adversely affecting function, independence, and quality of life.
Purpose
This study's purpose was to systematically review the literature to determine the strength of evidence relating the presence and severity of LBP secondary to LEA, thereby supporting the formulation of empirical evidence statements (EESs) to guide practice and future research.
Study Design/Setting
Systematic review of the literature.
Methods
A systematic review of five databases was conducted followed by evaluation of evidence and synthesis of EESs. This study was funded, in part, through an unrestricted gift by the Lincoln College Education and Research Fund to the University of South Florida Foundation.
Results
Seventeen manuscripts were included. From these, eight EESs were synthesized within the following categories: epidemiology, amputation level, function, disability, leg length, posture, spinal kinematics, osseointegrated prostheses. Only the EES on epidemiology was supported by evidence at the moderate confidence level given support by eight moderate quality studies. The four EESs for amputation level, leg length, posture and spinal kinematics were supported by evidence at the low confidence level given that each of these statements had some evidence not supporting the statement but ultimately more evidence (and of higher quality) currently supporting the statement. The remaining three EESs that addressed function, disability and osseointegrated prosthetic use were all supported by single studies or had comparable evidence that disagreed with study findings rendering insufficient evidence to support the respective EES.
Conclusions
Based on the state of the current evidence, appropriate preventative and particularly, treatment strategies to manage LBP in persons with LEA remains a knowledge gap and area of need for future study.
https://ift.tt/2PBRiac
Burkholderia pseudomallei-absent soil bacterial community results in secondary metabolites that kill this pathogen
Burkholderia pseudomallei is a Gram-negative bacterium found in soil and the causative agent of a severe disease in humans and animals known as melioidosis. It is intrinsically resistant to many antibiotics and h...
https://ift.tt/2Lo0vzv
Biotransformation of vanillin into vanillyl alcohol by a novel strain of Cystobasidium laryngis isolated from decaying wood
Vanillin is an aromatic aldehyde found as a component of lignocellulosic material, and in the cured pods of orchidaceae plants. Like other phenolic substances, vanillin has antimicrobial activity and can be extra...
https://ift.tt/2MLh5ON
Abnormal event detection in crowded scenes using histogram of oriented contextual gradient descriptor
Detecting abnormal events in crowded scenes is an important but challenging task in computer vision. Contextual information is useful for discovering salient events in scenes; however, it cannot be characteriz...
https://ift.tt/2BSxWL0
NRAS Q61K mutated diffuse leptomeningeal melanomatosis in an adult patient with a brief review of the so-called “forme fruste” of neurocutaneous melanosis
Abstract
Primary melanocytic tumors of central nervous system represent rare tumors arising from melanocytes of the leptomeninges. These neoplasms include focal forms like melanocytoma and primary malignant melanoma and diffuse forms like leptomeningeal melanocytosis and primary leptomeningeal melanomatosis. The clinical diagnosis remains challenging, with clinical and radiologic features overlapping with other more common diseases. Here we present a case of a 38 years old male with primary diffuse leptomeningeal melanomatosis with presence of a NRASQ61K mutation without features of neurocutaneous melanosis.
https://ift.tt/2w9RHbO
Circulating tumor cells and cell-free nucleic acids in patients with gynecological malignancies
Abstract
The ability to detect cancer cells in the blood or in the bone marrow offers invaluable information which potentially impacts early diagnosis, monitoring of treatment, and prognosis. Accessing blood or other body fluids has the additional advantage of being less invasive than biopsy. Consequently, considerable effort has been invested in the last 20 years in optimizing assays which may identify malignant cells at these anatomic sites. Detection of nucleic acids has been applied as alternative approach in this context, first targeting single cancer-associated genes using PCR-based technology, and recently using assays which identify different DNA classes, as well as microRNAs and exosomes. The present review focuses on studies which applied these assays to the detection of cells or cellular components originating from gynecological cancers.
https://ift.tt/2wmUNIR
Enhanced Cancer Vaccination by In Situ Nanomicelle-Generating Dissolving Microneedles.
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Enhanced Cancer Vaccination by In Situ Nanomicelle-Generating Dissolving Microneedles.
ACS Nano. 2018 Aug 24;:
Authors: Kim NW, Kim SY, Lee JE, Yin Y, Lee JH, Lim SY, Kim ES, Duong HTT, Kim HK, Kim S, Kim JE, Lee DS, Kim J, Lee MS, Lim YT, Jeong JH
Abstract
Efficient delivery of tumor antigens and immunostimulatory adjuvants into lymph nodes is crucial for the maturation and activation of antigen-presenting cells (APCs), which subsequently induce adaptive antitumor immunity. Dissolving microneedle (MN) has been considered as an attractive method for transcutaneous immunization due to its superior ability to deliver vaccines through the stratum corneum in a minimally invasive manner. However, since dissolving MNs are mostly prepared using water-soluble sugars or polymers for their rapid dissolution in intradermal fluid after administration, they are often difficult to formulate with poorly water-soluble vaccine components. Here, we develop amphiphilic tri-block copolymer-based dissolving MNs in situ that generate nanomicelles (NMCs) upon their dissolution after cutaneous application, which facilitate the efficient encapsulation of poorly water-soluble toll-like receptor 7/8 agonist (R848) and the delivery of hydrophilic antigens. The sizes of NMCs range from 30 to 40 nm, which is suitable for the efficient delivery of R848 and antigens to lymph nodes and promotion of cellular uptake by APCs, minimizing systemic exposure of the R848. Application of MNs containing tumor model antigen (OVA) and R848 to the skin of EG7-OVA tumor-bearing mice induced a significant level of antigen-specific humoral and cellular immunity, resulting in significant anti-tumor activity.
PMID: 30141896 [PubMed - as supplied by publisher]
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Effect of combination of pre- and postoperative pulmonary rehabilitation on onset of postoperative pneumonia: a retrospective cohort study based on data from the diagnosis procedure combination database in Japan
Abstract
Background
To examine the effect of rehabilitation on postoperative pulmonary complication when it is conducted in combination of both before and after lung cancer surgery, as compared with either before or after surgery and no rehabilitation.
Methods
A retrospective cohort study was conducted to examine the effect of rehabilitation before and after lung cancer surgery on the causes of postoperative pneumonia. Data were collected from the diagnosis procedure combination (DPC) database. Patients admitted who received operative treatment for a new primary (ICD codes: C34) were selected. The inclusion criteria were patients who had pneumonectomy, malignant tumor surgery for the lung (thoracotomy), or thoracoscopic surgery (endoscopic; treatment code: K511-00, K513-00~03, and K514-00, 02). The exclusion criteria were patients who had a lung transplantation (treatment code: K514-03~06), suspected diagnosis, and a pneumonia within 3 months before being diagnosed as having lung cancer. Main outcome was onset of postoperative pneumonia.
Results
Among 76,739 lung cancer patients, 15,146 who underwent lung cancer surgery were included in the analysis. In the combination of pre- and postoperative group, as compared with the preoperative [odds ratio (OR), 95% confidence interval (CI) 2.8, 1.8–4.4], postoperative (1.9, 1.6–2.3), and no rehabilitation group (2.5, 2.1–2.8), the onset of pneumonia was less frequent.
Conclusions
Combination of preoperative and postoperative rehabilitations significantly prevents postoperative pneumonia as compared with having preoperative, postoperative, or no rehabilitation.
https://ift.tt/2MN1fTz
The Role of Oncolytic Viruses in the Treatment of Melanoma
Abstract
Purpose of Review
Oncolytic virotherapy is a new approach to the treatment of cancer and its success in the treatment of melanoma represents a breakthrough in cancer therapeutics. This paper provides a review of the current literature on the use of oncolytic viruses (OVs) in the treatment of melanoma.
Recent Findings
Talimogene laherparepvec (T-VEC) is the first OV approved for the treatment of melanoma and presents new challenges as it enters the clinical setting. Several other OVs are at various stages of clinical and pre-clinical development for the treatment of melanoma. Reports from phase Ib-III clinical trials combining T-VEC with checkpoint blockade are encouraging and demonstrate potential added benefit of combination immunotherapy.
Summary
OVs have recently emerged as a standard treatment option for patients with advanced melanoma. Several OVs and therapeutic combinations are in development. Immunooncolytic virotherapy combined with immune checkpoint inhibitors is promising for the treatment of advanced melanoma.
https://ift.tt/2wetj8V
The assessment of the esophageal motility of children with esophageal disorders by the detailed observation of the pH–multichannel intraluminal impedance waveform and baseline impedance: screening test potential
Abstract
Background
The present study aimed to evaluate whether the detailed observation of pH/MII waveforms and the analysis of baseline impedance (BI) values could detect esophageal dysmotility in pediatric patients with esophageal disorders.
Patients and methods
Eleven patients with congenital esophageal disorder in whom pH/MII was conducted from April 2011 to June 2015, were enrolled in this study. The diagnoses of the patients were as follows: postoperative esophageal atresia (EA), n = 6; esophageal achalasia (EAch), n = 4; and congenital esophageal stenosis (CES), n = 1. The characteristics of the pH/MII waveform, pathological GERD, BI value, and the average BI value of the 2 distal channels (distal BI; DBI) were analyzed in each disorder.
Results
Two EA (33%) patients and one EAch (25%) patient were diagnosed with GERD. The mean DBI values of the EA, EAch and CES patients was 912 ± 550, 2153 ± 915 and 1392 Ω, respectively. The EA patients showed consistently low DBI values. One CES patient and two infantile EAch patients showed postprandial prolonged low DBI values. Whereas, the pH/MII waveforms of the adolescent EAch patients were difficult to interpret due to their extremely low BI values.
Conclusions
The present study demonstrated that the detailed observation of the pH/MII waveforms in all channels and the analysis of BI were useful for evaluating esophageal motility in children with congenital esophageal disorders. In particular, infantile patients with EAch showed DBI findings that were distinct from those of adult EAch patients. Considering the difficulty of performing esophageal manometry in young children, the detailed observation of the pH/MII waveform may help in the diagnosis of esophageal dysmotility in children.
https://ift.tt/2P4FrQY
Circumferential distribution and clinical characteristics of esophageal cancer in lower esophagus: differences related to histological subtype
Abstract
Background
Esophageal adenocarcinoma (EAC) is frequently found on the right-anterior wall of the distal esophagus in short-segment Barrett's esophagus (SSBE) patients. However, the endoscopic characteristics of EAC in cases with long-segment BE (LSBE) and squamous cell carcinoma (ESCC) in the lower esophagus remain to be fully evaluated. Here, we determined the circumferential distribution and clinical characteristics of esophageal cancer occurring in the lower esophagus based on histological subtype.
Methods
We retrospectively reviewed the medical records of 150 patients with esophageal cancer (ESCC, n = 100; EAC, n = 50) diagnosed at our hospital or a related facility between January 2002 and June 2017, including information regarding endoscopic findings, etiology, and clinical parameters.
Results
Of the 100 patients with ESCC, 28 lesions were located in the lower esophagus, though characteristic circumferential distribution was not seen regardless of location. Those showed a greater frequency of smoking and drinking habit and gastric mucosal atrophy as compared to patients with EAC. Consistent with the previous reports, EAC in SSBE (n = 41) was frequently located on the right-anterior wall. Likewise, EAC at the esophagogastric junction (EGJ) in LSBE was frequently located on the right-anterior wall, while EAC distant from the EGJ showed no characteristic circumferential distribution.
Conclusion
Our results showed no circumferential predilection for ESCC in the lower esophagus, suggesting that development of this type of lesion may be less affected by gastroesophageal reflux. In addition, EAC at the EGJ was frequently found on the right-anterior wall irrespective of BE length.
https://ift.tt/2w9E0tg
Cancers, Vol. 10, Pages 289: miRNA-205 Nanoformulation Sensitizes Prostate Cancer Cells to Chemotherapy
Cancers, Vol. 10, Pages 289: miRNA-205 Nanoformulation Sensitizes Prostate Cancer Cells to Chemotherapy
Cancers doi: 10.3390/cancers10090289
Authors: Prashanth K. B. Nagesh Pallabita Chowdhury Elham Hatami Vijaya K. N. Boya Vivek K. Kashyap Sheema Khan Bilal B. Hafeez Subhash C. Chauhan Meena Jaggi Murali M. Yallapu
The therapeutic application of microRNA(s) in the field of cancer has generated significant attention in research. Previous studies have shown that miR-205 negatively regulates prostate cancer cell proliferation, metastasis, and drug resistance. However, the delivery of miR-205 is an unmet clinical need. Thus, the development of a viable nanoparticle platform to deliver miR-205 is highly sought. A novel magnetic nanoparticle (MNP)-based nanoplatform composed of an iron oxide core with poly(ethyleneimine)-poly(ethylene glycol) layer(s) was developed. An optimized nanoplatform composition was confirmed by examining the binding profiles of MNPs with miR-205 using agarose gel and fluorescence methods. The novel formulation was applied to prostate cancer cells for evaluating cellular uptake, miR-205 delivery, and anticancer, antimetastasis, and chemosensitization potentials against docetaxel treatment. The improved uptake and efficacy of formulations were studied with confocal imaging, flow cytometry, proliferation, clonogenicity, Western blot, q-RT-PCR, and chemosensitization assays. Our findings demonstrated that the miR-205 nanoplatform induces significant apoptosis and enhancing chemotherapeutic effects in prostate cancer cells. Overall, these study results provide a strong proof-of-concept for a novel nonviral-based nanoparticle protocol for effective microRNA delivery to prostate cancer cells.
https://ift.tt/2BLexfd
Epithelial‐mesenchymal transition is activated in CD44 positive malignant ascites tumor cells of gastrointestinal cancer
Cancer Science, Volume 0, Issue ja, -Not available-.
https://ift.tt/2o96izP
Elevation of Androgen Receptor Promotes Prostate Cancer Metastasis via Induction of EMT and Reduction of KAT5
Cancer Science, Volume 0, Issue ja, -Not available-.
https://ift.tt/2LqQxxo
Novel therapeutic strategies for advanced ovarian cancer by using iPS cell‐derived myelomonocytic cells producing interferon beta
Cancer Science, Volume 0, Issue ja, -Not available-.
https://ift.tt/2o99hbu
Utility of the Quasi‐monomorphic Variation Range in Unresectable Metastatic Colorectal Cancer Patients
Cancer Science, Volume 0, Issue ja, -Not available-.
https://ift.tt/2BTR7V8
BPR1J373, a novel multi‐targeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor
Cancer Science, Volume 0, Issue ja, -Not available-.
https://ift.tt/2o9TA3X
Knockdown of LGALS12 inhibits porcine adipocyte adipogenesis via PKA–Erk1/2 signaling pathway
Abstract
Increasing intramuscular (IM) fat while concomitantly decreasing subcutaneous (SC) fat content is one major goal of pig breeding. Identifying genes involved in lipid metabolism is critical for this goal. Galectin-12 (LGALS12) has been proven to be an important regulator of fat deposition in mouse models; however, the effect and regulatory mechanisms of LGALS12 on porcine adipogenesis are still unknown. In this study, the effects of LGALS12 on fat deposition were explored with primary culture of porcine SC and IM adipocytes. Analysis of LGALS12 expression across different tissues revealed that LGALS12 was predominantly expressed in adipose tissue. The LGALS12 expression patterns across stages of adipocyte differentiation were also evaluated, with differences observed between SC and IM fat. Small interfering RNA (siRNA) of LGALS12 was designed and transfected into porcine adipocytes derived from SC and IM fat. After transfection, the expression level of LGALS12 was significantly reduced, and the number of lipid droplets was reduced in adipocytes from both SC and IM fat. Simultaneously, the levels of adipogenic markers, including PPARγ and aP2, were decreased, whereas hydrolysis markers, including adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL), were increased. Furthermore, the activation of lipolysis signals, such as the phosphorylation of PKA and Erk1/2, were observed with LGALS12 knockdown in terminally differentiated adipocytes from both SC and IM sources. Taken together, these results suggest that LGALS12 knockdown can inhibit adipogenesis of porcine adipocytes by downregulating lipogenic genes and activating the PKA–Erk1/2 signaling pathway.https://ift.tt/2w6DVXx
TGF-β signaling in cancer
Abstract
Signals from the transforming growth factor-β (TGF-β) superfamily mediate a broad spectrum of cellular processes and are deregulated in many diseases, including cancer. TGF-β signaling has dual roles in tumorigenesis. In the early phase of tumorigenesis, TGF-β has tumor suppressive functions, primarily through cell cycle arrest and apoptosis. However, in the late stage of cancer, TGF-β acts as a driver of tumor progression and metastasis by increasing tumor cell invasiveness and migration and promoting chemo-resistance. Here, we briefly review the mechanisms and functions of TGF-β signaling during tumor progression and discuss the therapeutic potentials of targeting the TGF-β pathway in cancer.https://ift.tt/2P5erAF
Further evidence for a differential interaction of brivaracetam and levetiracetam with the synaptic vesicle 2A protein
Epilepsia, EarlyView.
https://ift.tt/2P1fsdd
Psychiatric comorbidity and traumatic brain injury attribution in patients with psychogenic nonepileptic or epileptic seizures: A multicenter study of US veterans
Epilepsia, EarlyView.
https://ift.tt/2MIXcIb
Techniques for placement of stereotactic electroencephalographic depth electrodes: Comparison of implantation and tracking accuracies in a cadaveric human study
Epilepsia, EarlyView.
https://ift.tt/2Lp0ewq
The use of antidepressant drugs in pregnant women with epilepsy: A study from the Australian Pregnancy Register
Epilepsia, EarlyView.
https://ift.tt/2MyvgHG
Design and synthesis of 5‐(5‐nitrothiophen‐2‐yl)‐3‐phenyl‐4,5‐dihydro‐1H‐pyrazole derivatives with improved solubility and potential antituberculosis activity
Chemical Biology &Drug Design, Volume 0, Issue ja, -Not available-.
https://ift.tt/2wtPk38
Extending the developmental origins of disease model: Impact of preconception stress exposure on offspring neurodevelopment
Developmental Psychobiology, EarlyView.
https://ift.tt/2LqGGrh
Issue Information
Developmental Psychobiology, Volume 60, Issue 6, Page 625-628, September 2018.
https://ift.tt/2MMjWXG
Tumor‐shed antigen CA125 blocks complement‐mediated killing via suppression of C1q‐antibody binding
European Journal of Immunology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2NjgmRY
Eomes controls the development of Th17‐derived (non‐classic) Th1 cells during chronic inflammation
European Journal of Immunology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2wbVi9g
RESPONDER – diagnosis of pathological complete response by vacuum-assisted biopsy after neoadjuvant chemotherapy in breast Cancer - a multicenter, confirmative, one-armed, intra-individually-controlled, open, diagnostic trial
Abstract
Background
Neoadjuvant chemotherapy (NACT) is a standard approach of the multidisciplinary treatment of breast cancer. Depending on the biological subtype a pathological complete response in the breast (bpCR) can be achieved in up to 60% of the patients. However, only limited accuracy can be reached when using imaging for prediction of bpCR prior to surgery. Due to this diagnostic uncertainty, surgery after NACT is considered to be obligatory for all patients in order to either completely remove residual disease or to diagnose a bpCR histologically. The purpose of this trial is to evaluate the accuracy of a vacuum-assisted biopsy (VAB) to diagnose a bpCR after NACT prior to surgery.
Methods
This study is a multicenter, confirmative, one-armed, intra-individually-controlled, open, diagnostic trial. The study will take place at 21 trial sites in Germany. Six hundred female patients with breast cancer after completed NACT showing at least a partial response to NACT treatment will be enrolled. A vacuum-assisted biopsy (VAB) guided either by ultrasound or mammography will be performed followed by histopathological evaluation of the VAB specimen before standard, guideline-adherent breast surgery. The study is designed to prove that the false negative rate of the VAB is below 10%.
Discussion
As a bpCR is becoming a more frequent result after NACT, the question arises whether breast surgery is therapeutically necessary in such cases. To study this subject further, it will be crucial to develop a reliable test to diagnose a bpCR without surgery.
During the study we anticipate possible problems in patient recruitment as the VAB intervention does not provide participating patients with any personal benefit. Hence, a proficient informed consent discussion with the patient and a detailed explanation of the study aim will be crucial for patient recruitment. Another critical issue is the histopathological VAB evaluation of a non-tumorous specimen as this may have been taken either from the former tumor region (bpCR) or outside of the (former) tumor region (non-representative VAB, sampling error).
Trial registration
The trial has been registered at clinicaltrials.gov with the identifier NCT02948764 on October 28, 2016 and at the German Clinical Trials Register (DRKS00011761) on February 20, 2017. The date of enrolment of the first participant to the trial was on March 8, 2017.
https://ift.tt/2NeXrHP
When Enough Is Not Enough: Screening, Brief Intervention and Referral to Treatment for Hepatitis C in Patients Presenting to the Emergency Department
Academic Emergency Medicine, Volume 0, Issue ja, -Not available-.
https://ift.tt/2MQ2Ub2
Long‐term results of osseointegrated implant‐based dental rehabilitation in oncology patients reconstructed with a fibula free flap
Clinical Implant Dentistry and Related Research, EarlyView.
https://ift.tt/2P7vDWv
Long‐term stability of autologous bone graft of intraoral origin after lateral sinus floor elevation with simultaneous implant placement
Clinical Implant Dentistry and Related Research, EarlyView.
https://ift.tt/2MvF4C5
Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals
BioEssays, EarlyView.
https://ift.tt/2LqxSll
Acute Effects of Meditation Training on the Waking and Sleeping Brain: is it all about homeostasis?
European Journal of Neuroscience, Volume 0, Issue ja, -Not available-.
https://ift.tt/2wdlBvH
Modulating auditory selective attention by non‐invasive brain stimulation: Differential effects of transcutaneous vagal nerve stimulation and transcranial random noise stimulation
European Journal of Neuroscience, Volume 0, Issue ja, -Not available-.
https://ift.tt/2BGupQ5
Targeting Redox Regulation to Treat Substance Use Disorder using N‐acetylcysteine
European Journal of Neuroscience, Volume 0, Issue ja, -Not available-.
https://ift.tt/2o9h2yl
Female genital mutilation and non‐invasive cervical abnormalities and invasive cervical cancer in Senegal, West Africa: A retrospective study
International Journal of Cancer, Volume 0, Issue ja, -Not available-.
https://ift.tt/2P3XZ3E
BRAFV600E mutation: A promising target in colorectal neuroendocrine carcinoma
International Journal of Cancer, Volume 0, Issue ja, -Not available-.
https://ift.tt/2PCbLMc
Patient Reported Outcome Measures (PROMs) of posterior single‐implant crowns using digital workflows: A randomized controlled trial with a three‐year follow‐up
Clinical Oral Implants Research, EarlyView.
https://ift.tt/2P4gt4c
Exposing {010} Active Facets by Multiple‐Layer Oriented Stacking Nanosheets for High‐Performance Capacitive Sodium‐Ion Oxide Cathode
Advanced Materials, EarlyView.
https://ift.tt/2P21bwY
Abnormal Near‐Infrared Absorption in 2D Black Phosphorus Induced by Ag Nanoclusters Surface Functionalization
Advanced Materials, EarlyView.
https://ift.tt/2MtLlhL
Protein‐Corona‐by‐Design in 2D: A Reliable Platform to Decode Bio–Nano Interactions for the Next‐Generation Quality‐by‐Design Nanomedicines
Advanced Materials, EarlyView.
https://ift.tt/2P218RO
Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis
Alimentary Pharmacology &Therapeutics, EarlyView.
https://ift.tt/2PGpZM6
Histologic Features and Prognostic Significance of Treatment Effect in Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma
Histopathology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2Nfszqx
Novel EPC1 gene fusions in endometrial stromal sarcoma
Genes, Chromosomes and Cancer, EarlyView.
https://ift.tt/2P4FBHZ
Correction to: Ileocolic intussusception due to a cecal endometriosis: Case report and review of literature
After publication of this work [1], the authors noticed that the first names and last names of all the authors were inverted. In the original manuscript, they appear on PubMed as:
https://ift.tt/2PCIuB5
Per-oral Pyloromyotomy (POP) for Medically Refractory Gastroparesis: Short Term Results From the First 100 Patients at a High Volume Center
Objective: For patients with gastroparesis, temporary pyloric disruption has been shown to improve symptoms and gastric emptying. Per-oral pyloromyotomy (POP) is an innovative endoscopic procedure to divide the pylorus from within a submucosal tunnel, as a corollary to surgical pyloromyotomy. Here we evaluate subjective and objective outcomes 12-weeks after POP at a high volume center. Methods: The first 100 consecutive patients undergoing POP were included, with procedure dates between January 2016 and October 2017. Patients were evaluated using the Gastroparesis Cardinal Symptom Index (GCSI), and 4-hour solid-phase scintigraphic gastric emptying studies (GES) prior to procedure and at 90 days post-POP Results: The study cohort was 85% female with a mean age of 45.0 ± 14.6 years. Gastroparesis etiologies were divided among idiopathic (56%), diabetic (21%), postsurgical (19%), and other in 4%. There were 67% of the patients who had previous endoscopic or surgical interventions for gastroparesis. Most POP procedures were performed in the operating room (97%) and were completed in an average of 33 minutes. Ten patients incurred complications (10%), which included 1 diagnostic laparoscopy and 2 cases of gastrointestinal bleeding. Overall GCSI improved from a preoperative mean of 3.82 ± 0.86 to 2.54 ± 1.2 (Phttps://ift.tt/2vKlMOS
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Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
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heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
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