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Ιουν 12
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- S1P1 receptor inhibits kidney epithelial mesenchym...
- Cancers, Vol. 10, Pages 197: Antiviral Drugs for EBV
- Improved Targeting and Tumor Retention of a Newly ...
- Histological study of the thin membranous structur...
- RSS Story 01
- Allogeneic hematopoietic cell transplantation in p...
- Comprehensive Safety Analysis of Venetoclax Monoth...
- Inhibition of HER2 Enriches for Jagged1-dependent ...
- The widening spectrum of immunological memory
- Older Age, ICU, Poor Renal Fcn Up Risk of Opioid O...
- Meds With Depression As Adverse Side Effect Common...
- USPSTF: No to ECG Screening to Prevent CVD in Low-...
- How Do Business Partner Data Breaches Affect Your ...
- Exercise May Lower Mortality in Adult Survivors of...
- Midlife weight gain is a risk factor for obesity-r...
- A Rapidly Fatal Case of Low-Dose Methotrexate Toxi...
- A Risk Score Model for Evaluation and Management o...
- Psychological Symptoms and Well-Being After Treatm...
- Relation of RANKL and OPG Levels with Bone Resorpt...
- Improving PHA production in a SBR of coupling PHA-...
- Purification and characterization of neutral prote...
- A Changing Landscape in Pancreatic Cancer
- Response: “Prophylactic Negative Pressure Dressing...
- The Southampton Consensus Guidelines for Laparosco...
- Response to: “Are Guidelines for Standardized Outc...
- Overall Splenectomy Rates Stable Despite Increasin...
- Response to: “Consideration of KRAS Mutation Statu...
- Value-based Surgical Care: Evidence for the Enigma
- DCIS and Breast Cancer: Challenging the Paradigm
- A Framework for a Battlefield Trauma System for Ci...
- Opioid Overdose—the Surgeon's Role
- Efficacy of a Dual-ring Wound Protector for Preven...
- Mystery of Liver Regeneration After Portal Flow Ch...
- Incisional Hernia After Midline Versus Transverse ...
- Response to: “Why Morbidity is Not an Adequate Met...
- Interventions to Reduce Intraoperative Costs: A Sy...
- Management of haemostatic alterations and associat...
- Timing of Gastrointestinal Bleeding After Implanta...
- Rapid Fire: Central Nervous System Emergencies
- Rapid Fire: Superior Vena Cava Syndrome
- Emergency Medicine Evaluation and Management of An...
- The Oncologic Emergency Medicine Fellowship
- Midlife weight gain is a risk factor for obesity-r...
- EUS and confocal endomicroscopic diagnosis of panc...
- Rapid Fire: Central Nervous System Emergencies
- Rapid Fire: Superior Vena Cava Syndrome
- Emergency Medicine Evaluation and Management of An...
- The Oncologic Emergency Medicine Fellowship
- Modified technique for imaging the wrist and elbow...
- Correction to: GLP-I secretion in healthy and diab...
- Relationship between the geometry patterns of vert...
- Correction to: Case series of Creutzfeldt-Jakob di...
- Biotin-based Pulldown Assay to Validate mRNA Targe...
- Deposition of Porous Sorbents on Fabric Supports
- Active Failures Seen in Proper Use of Personal Pro...
- Increase in Global Cancer Incidence, Drop in Death...
- Female Teens, Young Adults Not Getting Enough Exer...
- Adverse Change in Employment Post-MI Tied to Worse...
- Most Infants and Toddlers Consume Added Sugar
- APAGBI: Teens 13+ Should Be Assessed for VTE Proph...
- Long-Term Type 1 Diabetes Associated With Cognitiv...
- Eleven tips for white spots on teeth
- Clinicopathological features and outcome of type 3...
- Meta‐analysis of the effect of bariatric surgery o...
- Neoadjuvant chemotherapy response influences outco...
- Magnetic resonance tumour regression grade and pat...
- Prediction of Safety Margin and Optimization of Do...
- Anisomycin Activates Utrophin Upregulation Through...
- Zygotic Fluorescence Recovery After Photo-bleachin...
- RNA interference targeting CD147 inhibits metastas...
- Disturbances of spatial reference frame and postur...
- A Quantitative Dot Blot Assay for AAV Titration an...
- Finite element analysis of the influence of three‐...
- Few‐view CT reconstruction with group‐sparsity reg...
- Issue Information
- Cover Image
- An “Omics” Approach for Lipid Oxidation in Foods: ...
- Enzymatic Interesterification of Heterotrophic Mic...
- Influence of apical enlargement on the repair of a...
- Release of TGF‐β1 into root canals with various fi...
- Issue Information
- External cervical resorption: part 2 – management
- Substance P and Calcitonin gene‐related peptide ex...
- An analysis of the timing and materials associated...
- Clinical implication of FMR1 intermediate alleles ...
- Issue Information ‐ Editorial Board
- Discovery of 4 exonic and 1 intergenic novel susce...
- Association between glutathione S‐transferase gene...
- Bilateral cerebellar cysts and cerebral white matt...
- Overlapping but distinct roles for NOTCH receptors...
- Further audiovestibular characterization of DFNB77...
- Pathogenetic implication of fusion genes in acute ...
- Genetic analysis of adult leukoencephalopathy pati...
- Metagenomic insights into diazotrophic communities...
- Birds, feather-degrading bacteria and preen glands...
- Patient information needs in upper gastrointestina...
- Inflammatory calcified de‐differentiated liposarco...
- Pattern of care for cancer of the oesophagus in a ...
- Jejunal angiosarcoma: a rare cause of obscure gast...
- Comparison of lipase and amylase for diagnosing po...
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Αναζήτηση αυτού του ιστολογίου
Τρίτη 12 Ιουνίου 2018
S1P1 receptor inhibits kidney epithelial mesenchymal transition triggered by ischemia/reperfusion injury via the PI3K/Akt pathway
https://ift.tt/2tafDd1
Cancers, Vol. 10, Pages 197: Antiviral Drugs for EBV
Cancers, Vol. 10, Pages 197: Antiviral Drugs for EBV
Cancers doi: 10.3390/cancers10060197
Authors: Joseph S. Pagano Christopher B. Whitehurst Graciela Andrei
Epstein–Barr virus (EBV) infects up to 95% of the adult human population, with primary infection typically occurring during childhood and usually asymptomatic. However, EBV can cause infectious mononucleosis in approximately 35–50% cases when infection occurs during adolescence and early adulthood. Epstein–Barr virus is also associated with several B-cell malignancies including Burkitt lymphoma, Hodgkin lymphoma, and post-transplant lymphoproliferative disease. A number of antiviral drugs have proven to be effective inhibitors of EBV replication, yet have resulted in limited success clinically, and none of them has been approved for treatment of EBV infections.
https://ift.tt/2JNRDGI
Improved Targeting and Tumor Retention of a Newly Synthesized Antineoplaston A10 Derivative by Intratumoral Administration: Molecular Docking, Technetium 99m Radiolabeling, and In Vivo Biodistribution Studies
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
https://ift.tt/2MlYVQv
Histological study of the thin membranous structure made of dense connective tissue around the esophagus in the upper mediastinum
Abstract
Background
The structure of the fascia in upper mediastinum has already been reported from gross anatomical viewpoints by Sarrazin. But it is necessary to understand meticulous anatomy for thoracoscopic or mediastinoscopic surgery. So herein, we investigate histologically the thin membranous structure made of dense connective tissues.
Methods
Semi-sequential transverse sections of the mediastinum were obtained from three cadavers. Hematoxylin and eosin staining, Elastica van Gieson staining, and Masson trichrome staining were performed to identify the presence and location of the thin membranous structure made of dense connective tissues.
Results
The "visceral sheath" and "vascular sheath," as previously described by Sarrazin, were observed histologically. These two thin membranous structures do not surround the esophagus and trachea cylindrically. In addition, the "visceral sheath" on the right side of the upper mediastinum was unclear in comparison to the left side. The "visceral sheath" (on the left side) gradually became unclear, and seemed to almost disappear; the esophagus was found to be very close to the thoracic duct on the caudal side of the bifurcation of the trachea. Although the left recurrent nerve was located inside the "visceral sheath" in all cadavers, the left recurrent nerve lymph nodes were located inside the "visceral sheath" in cadaver 1 and between the "visceral sheath" and "vascular sheath" in cadaver 3.
Conclusion
The "visceral sheath" around the esophagus in the upper mediastinum was histologically demonstrated; however, the findings were not constant.
https://ift.tt/2MlWXzG
RSS Story 01
RSS Story 01 Lorem ipsum dolor sit amet, consectetur adipiscing elit. Phasellus dignissim dapibus erat, non hendrerit tortor tempus sed....
https://ift.tt/2l4mxN1
Allogeneic hematopoietic cell transplantation in patients with GATA2 deficiency—a case report and comprehensive review of the literature
Abstract
Recently, an immunodeficiency syndrome caused by guanine-adenine-thymine-adenine 2 (GATA2) deficiency has been described. The syndrome is characterized by (i) typical onset in early adulthood, (ii) profound peripheral blood cytopenias of monocytes, B lymphocytes, and NK cells, (iii) distinct susceptibility to disseminated non-tuberculous mycobacterial (NTM) and other opportunistic infections (particularly human papillomavirus), and (iv) a high risk of developing hematologic malignancies (myelodysplastic syndromes (MDS); acute myeloid leukemias (AML)). Considerable clinical heterogeneity exists among patients with GATA2 deficiency, but once infectious symptoms occur or MDS/AML arises, survival declines significantly. Allogeneic hematopoietic cell transplantation (HCT) currently provides the only curative treatment option for both MDS/AML and dysfunctional immunity with life-threatening opportunistic infections. Strategies regarding timing of allogeneic HCT, antimicrobial prophylaxis and treatment, intensity of the preparative regimen, and optimal donor and graft source have not been clearly defined due to the rarity of the disease. Here, we provide a comprehensive analysis of the available literature and published case reports on the use of allogeneic HCT in patients with GATA2 deficiency. In addition, a case of a young woman with GATA2 deficiency, who developed an immune reconstitution inflammatory syndrome in her mycobacterial skin lesions post allogeneic HCT is presented and illustrates distinct problems encountered in this disease context.
https://ift.tt/2Mka9VA
Comprehensive Safety Analysis of Venetoclax Monotherapy for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia
Purpose: The oral BCL-2 inhibitor venetoclax is an effective therapy for patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL), including disease with high-risk genomic features such as chromosome 17p deletion (del[17p]) or progressive disease following B-cell receptor pathway inhibitors. Experimental Design: We conducted a comprehensive analysis of the safety of 400mg daily venetoclax monotherapy in 350 patients with CLL using an integrated dataset from three phase-I/II studies. Results: Median age was 66 years and 60% had del(17p). Patients had received a median of three prior therapies (range: 0-15); 42% previously received ibrutinib or idelalisib. Median duration of exposure to venetoclax was 16 months (0-56). In the pooled analysis, the most common adverse events (AEs) of any grade were diarrhea (41%), neutropenia (40%), nausea (39%), anemia (31%), fatigue (28%), and upper respiratory tract infection (25%). The most common grade 3/4 AEs were neutropenia (37%), anemia (17%), and thrombocytopenia (14%). With the current 5-week ramp-up dosing, the incidence of laboratory TLS was 1.4% (2/166), none had clinical sequelae, and all of these patients were able to ramp-up to a daily dose of 400mg. Grade 3/4 neutropenia was manageable with growth-factor support and dose adjustments; the incidence of serious infections in these patients was 15%. Ten percent of patients discontinued venetoclax due to AEs and 8% died while on study, with the majority of deaths in the setting of disease progression. Conclusions: Venetoclax as a long-term continuous therapy is generally well-tolerated in patients with R/R CLL when initiated with the current treatment algorithm.
https://ift.tt/2l7CD8N
Inhibition of HER2 Enriches for Jagged1-dependent Breast Cancer Stem Cells: Role for Membrane Jagged1
Purpose: Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer is driven by cells possessing stem-like properties of self-renewal and differentiation, referred to as Cancer Stem Cells (CSCs). CSCs are implicated in radiotherapy, chemotherapy resistance, and tumor recurrence. Notch promotes breast CSCs survival and self-renewal, and overexpression of Notch1 and the Notch ligand Jagged1 predict poor outcome. Resistance to anti-HER2 therapy in HER2+ breast cancer requires Notch1, and that combination of trastuzumab and a Gamma Secretase Inhibitor (GSI) prevents tumor relapse in xenograft models. Experimental Design: The current study investigates mechanisms by which HER2 tyrosine kinase activity regulates Notch-dependent CSC survival and tumor initiation. Results: Lapatinib-mediated HER2 inhibition shifts the population of HER2+ breast cancer cells from low membrane Jagged1 expressing to higher levels, independent of sensitivity to anti-HER2 treatment within the bulk cell population. This increase in membrane Jagged1 is associated with higher Notch receptor expression, activation, and enrichment of CSCs in vitro and in vivo. Importantly, lapatinib treatment results in growth arrest and cell death of Jagged1 low-expressing cells while the Jagged1 high-expressing cells continue to cycle. High membrane Jagged1 protein expression predicts poor overall cumulative survival in women with HER2+ breast cancer. Conclusions: These results indicate that higher membrane Jagged1 expression may be used to either predict response to anti-HER2 therapy or for detection of Notch sensitive CSCs post therapy. Sequential blockade of HER2 followed by Jagged1 or Notch could be more effective than simultaneous blockade to prevent drug resistance and tumor progression.
https://ift.tt/2l7CulL
Older Age, ICU, Poor Renal Fcn Up Risk of Opioid OD in Hospital
TUESDAY, June 12, 2018 -- Risk factors for opioid overdose among hospitalized patients include being age 65 years or older, being in an intensive care unit (ICU), and having renal impairment, according to a study published online May 23 in the...
https://ift.tt/2JFLZ6d
Meds With Depression As Adverse Side Effect Commonly Used
TUESDAY, June 12, 2018 -- The estimated prevalence of using medications with depression as an adverse effect is 37.2 percent, according to a study published in the June 12 issue of the Journal of the American Medical Association. Dima Mazen Qato,...
https://ift.tt/2Jy3lGn
USPSTF: No to ECG Screening to Prevent CVD in Low-Risk Adults
TUESDAY, June 12, 2018 -- The U.S. Preventive Services Task Force (USPSTF) recommends against screening with resting or exercise electrocardiography (ECG) to prevent cardiovascular disease (CVD) events in low-risk asymptomatic adults. This final...
https://ift.tt/2y5BO9N
How Do Business Partner Data Breaches Affect Your Practice?
TUESDAY, June 12, 2018 -- Data breaches affecting health care systems or their partners need to be addressed quickly, according to an article published in Medical Economics. Noting that every successful breach against a health care system...
https://ift.tt/2MnOXhp
Exercise May Lower Mortality in Adult Survivors of Childhood CA
TUESDAY, June 12, 2018 -- For adult survivors of childhood cancer, vigorous exercise in early adulthood is associated with reduced risk of mortality, according to a study published online June 3 in JAMA Oncology. Jessica M. Scott, Ph.D., from the...
https://ift.tt/2JDRKkJ
Midlife weight gain is a risk factor for obesity-related cancer
Midlife weight gain is a risk factor for obesity-related cancer
Midlife weight gain is a risk factor for obesity-related cancer, Published online: 13 June 2018; doi:10.1038/s41416-018-0106-x
Midlife weight gain is a risk factor for obesity-related cancerhttps://ift.tt/2sQ4sH2
A Rapidly Fatal Case of Low-Dose Methotrexate Toxicity
An 82-year-old female presented with multiple oral ulcers and malena for 1 week. Her laboratory tests revealed pancytopenia and acute renal failure. She had history of rheumatoid arthritis for which she was taking 7.5 mg methotrexate weekly and stage 4 chronic kidney disease from diabetic nephropathy. During the hospital stay, she developed pneumonia and septic shock requiring norepinephrine and vasopressin. She underwent continuous venovenous hemodiafiltration. Leucovorin, filgrastim, and multiple packed red blood cell and platelet transfusions were given. She remained hypotensive and pancytopenic despite all interventions. She died on day 6 of hospital stay from acute hypoxic respiratory failure due to septic shock.
https://ift.tt/2sRkgJs
A Risk Score Model for Evaluation and Management of Patients with Thyroid Nodules
Horm Metab Res
DOI: 10.1055/a-0630-5239
The study is aimed to establish a simplified and practical tool for analyzing thyroid nodules. A novel risk score model was designed, risk factors including patient history, patient characteristics, physical examination, symptoms of compression, thyroid function, ultrasonography (US) of thyroid and cervical lymph nodes were evaluated and classified into high risk factors, intermediate risk factors, and low risk factors. A total of 243 thyroid nodules in 162 patients were assessed with risk score system and Thyroid Imaging-Reporting and Data System (TI-RADS). The diagnostic performance of risk score system and TI-RADS was compared. The accuracy in the diagnosis of thyroid nodules was 89.3% for risk score system, 74.9% for TI-RADS respectively. The specificity, accuracy and positive predictive value (PPV) of risk score system were significantly higher than the TI-RADS system (χ2=26.287, 17.151, 11.983; p <0.05), statistically significant differences were not observed in the sensitivity and negative predictive value (NPV) between the risk score system and TI-RADS (χ2=1.276, 0.290; p>0.05). The area under the curve (AUC) for risk score diagnosis system was 0.963, standard error 0.014, 95% confidence interval (CI)=0.934–0.991, the AUC for TI-RADS diagnosis system was 0.912 with standard error 0.021, 95% CI=0.871–0.953, the AUC for risk score system was significantly different from that of TI-RADS (Z=2.02; p <0.05). Risk score model is a reliable, simplified and cost-effective diagnostic tool used in diagnosis of thyroid cancer. The higher the score is, the higher the risk of malignancy will be.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
https://ift.tt/2HH12ux
Psychological Symptoms and Well-Being After Treatment for Primary Aldosteronism
Horm Metab Res
DOI: 10.1055/a-0628-6847
Primary aldosteronism (PA) is an increasingly identified cause of secondary hypertension. PA can be caused by an aldosterone-producing adenoma or by bilateral adrenal hyperplasia, generally treated by adrenalectomy or mineralocorticoid receptor antagonists, respectively. Recent studies suggest that PA is associated with more psychological symptoms and lower levels of well-being. The purpose of this study was to investigate the associations between subtype of PA and psychological symptoms and well-being after specific treatment. We analyzed the outcomes of the Mental Health Continuum-Short Form and the Symptom Checklist in 160 patients (mean age 57 years; 74.3% males) with PA, comparing the scores for psychological symptoms and well-being between both subtypes of PA. Additionally, we performed subgroup analyses based on gender, age, time since initiation of treatment, and co-morbidity. Moreover, we compared the results with published norm scores. Mean follow-up after adrenalectomy or start of medication was four years and two months. Depressive symptoms, anxiety and obsessive-compulsive thoughts and well-being did not differ between subtypes of PA. Subgroup analysis did not reveal any differences, except for women with bilateral adrenal hyperplasia who scored higher on the anxiety subscale than women after adrenalectomy. Compared to the general population, patients with treated PA reported more psychological symptoms. In contrast, well-being did not differ significantly from norm scores. Subtype and treatment of PA were no important determinants of psychological symptoms and well-being on the long-term. We suggest that physicians should be alert for psychological symptoms, as these were more frequently present in patients with PA.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
https://ift.tt/2JPsviI
Relation of RANKL and OPG Levels with Bone Resorption in Patients with Acromegaly and Prolactinoma
Horm Metab Res
DOI: 10.1055/a-0630-1529
The objective of this study was to investigate the effect of hyperprolactinemia and high levels of insulin-like growth factor-I (IGF-I) on bone resorption and their relation with receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) in patients with prolactinoma and acromegaly. Thirty-one patients with acromegaly, 28 patients with prolactinoma, and 33 healthy individuals were included in the study. Serum concentrations of RANKL, OPG, bone alkaline phosphatase (bone ALP), osteocalcin (OC), C-terminal telopeptide of type 1 collagen (CTX), procollagen type 1 N-terminal propeptide (P1NP) and urine deoxypyridinoline (DPD) levels were detected and bone mineral density (BMD) was measured. Groups were not statistically different from each other with regard to serum levels of RANKL and OPG. The RANKL/OPG ratio was higher in the prolactinoma group than in the control group (p=0.046). A positive correlation between OPG and increasing age was detected in both the prolactinoma and control groups (r=0.524, p=0.004 and r=0.380, p=0.029, respectively). An inverse correlation was observed between IGF-I and OPG after excluding age in the prolactinoma group (r=–0.412, p=0.046). OC and bone ALP were negatively associated with RANKL in the acromegaly group (r=–0.384, p=0.036 and r=–0.528, p=0.003, respectively). There was an inverse correlation between OPG and BMD at the femoral neck in the acromegaly group (r=–0.422, p=0.02). The effect of IGF-I on bone remodeling may be partly mediated by RANKL and OPG. The RANKL/OPG ratio plays an important role in prolactinoma. A positive correlation of OPG with age and an inverse correlation with IGF-I favor the compensatory response of OPG against bone loss in the aging skeleton.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
https://ift.tt/2HIv01p
Improving PHA production in a SBR of coupling PHA-storing microorganism enrichment and PHA accumulation by feed-on-demand control
With volatile fatty acids as substrates, the typical polyhydroxyalkanoates (PHAs) production by mixed culture always includes two steps: PHA-storing culture enrichment via aerobic dynamic feeding strategy and ...
https://ift.tt/2sYwhNt
Purification and characterization of neutral protease from Aspergillus oryzae Y1 isolated from naturally fermented broad beans
The strain Y1, with a notably high production of neutral protease, was isolated from naturally fermented broad beans and subsequently identified as Aspergillus oryzae, through the analysis of its morphology chara...
https://ift.tt/2LK6izX
The Southampton Consensus Guidelines for Laparoscopic Liver Surgery: From Indication to Implementation
https://ift.tt/2t6s6ym
Overall Splenectomy Rates Stable Despite Increasing Usage of Angiography in the Management of High-grade Blunt Splenic Injury
https://ift.tt/2l6MqMk
Opioid Overdose—the Surgeon's Role
https://ift.tt/2l3AvPh
Efficacy of a Dual-ring Wound Protector for Prevention of Surgical Site Infections After Pancreaticoduodenectomy in Patients With Intrabiliary Stents: A Randomized Clinical Trial
https://ift.tt/2t6s1e2
Incisional Hernia After Midline Versus Transverse Specimen Extraction Incision: A Randomized Trial in Patients Undergoing Laparoscopic Colectomy
https://ift.tt/2l64q9s
Interventions to Reduce Intraoperative Costs: A Systematic Review
https://ift.tt/2sZpBh6
Management of haemostatic alterations and associated disorders in cirrhosis in Spain: a national survey
knowledge of haematological abnormalities in cirrhosis has greatly improved in recent years.
https://ift.tt/2JC0kk6
Timing of Gastrointestinal Bleeding After Implantation of Left Ventricular Assist Devices Associates With Anatomic Location, Presentation, and Management
Continuous-flow left ventricular assist devices (LVADs) for advanced heart failure have been associated with gastrointestinal bleeding (GIB). We examined the association between time of GIB after LVAD implantation and bleeding location (determined by endoscopy), etiology, and patient outcomes.
https://ift.tt/2y3DKjd
Rapid Fire: Central Nervous System Emergencies
Neurologic complications are unfortunately common in oncology patients, with many presenting to the emergency department for diagnosis and management. This case-based review provides a brief overview of the key points in pathophysiology, diagnosis, and management of 2 oncologic central nervous system emergencies: malignant spinal cord compression and intracranial mass.
https://ift.tt/2t7f0Rs
Rapid Fire: Superior Vena Cava Syndrome
Superior vena cava syndrome occurs from obstruction of the superior vena cava. The most common cause is malignancy. Small cell lung cancer and non-Hodgkin lymphoma are the most frequent culprits. Intravascular devices associated with thrombus are becoming more common causes. Classic symptoms include edema, plethora, and distended veins of the face, neck, and chest; shortness of breath; cough; headache; and hoarseness. Treatment in the emergency department is mostly supportive, with head elevation, oxygen, and steroids. Rarely, emergent airway issues and cerebral edema must be addressed. Definitive treatment includes radiotherapy, chemotherapy, and stenting.
https://ift.tt/2l5a3Vq
Emergency Medicine Evaluation and Management of Anemia
Anemia is a common condition and is diagnosed on laboratory assessment. It is defined by abnormally low hemoglobin concentration or decreased red blood cells. Several classification systems exist. Laboratory markers provide important information. Acute anemia presents with symptoms owing to acute blood loss; chronic anemia may present with worsening fatigue, dyspnea, lightheadedness, or chest pain. Specific treatments depend on the underlying anemia and etiology. Iron is an alternative treatment for patients with microcytic anemia owing to iron deficiency. Hyperbaric oxygen is an option for alternative rescue therapy. Most patients with chronic anemia may be discharged with follow-up if hemodynamically stable.
https://ift.tt/2y3BXKI
The Oncologic Emergency Medicine Fellowship
The United States cancer population is growing and is projected to grow further. The current cancer population has a high rate of emergency department admission. Further training about oncologic emergencies may be needed and would ideally strive to care for the whole patient, including sequelae of the malignancy, progressive disease, symptom control, adverse effects of treatment, and palliative care. The James Cancer Hospital at The Ohio State University Wexner Medical Center and The University of Texas MD Anderson Cancer Center fellowship training programs in oncologic emergency medicine are described.
https://ift.tt/2JI1pqy
Rapid Fire: Central Nervous System Emergencies
Neurologic complications are unfortunately common in oncology patients, with many presenting to the emergency department for diagnosis and management. This case-based review provides a brief overview of the key points in pathophysiology, diagnosis, and management of 2 oncologic central nervous system emergencies: malignant spinal cord compression and intracranial mass.
https://ift.tt/2t7f0Rs
Rapid Fire: Superior Vena Cava Syndrome
Superior vena cava syndrome occurs from obstruction of the superior vena cava. The most common cause is malignancy. Small cell lung cancer and non-Hodgkin lymphoma are the most frequent culprits. Intravascular devices associated with thrombus are becoming more common causes. Classic symptoms include edema, plethora, and distended veins of the face, neck, and chest; shortness of breath; cough; headache; and hoarseness. Treatment in the emergency department is mostly supportive, with head elevation, oxygen, and steroids. Rarely, emergent airway issues and cerebral edema must be addressed. Definitive treatment includes radiotherapy, chemotherapy, and stenting.
https://ift.tt/2l5a3Vq
Emergency Medicine Evaluation and Management of Anemia
Anemia is a common condition and is diagnosed on laboratory assessment. It is defined by abnormally low hemoglobin concentration or decreased red blood cells. Several classification systems exist. Laboratory markers provide important information. Acute anemia presents with symptoms owing to acute blood loss; chronic anemia may present with worsening fatigue, dyspnea, lightheadedness, or chest pain. Specific treatments depend on the underlying anemia and etiology. Iron is an alternative treatment for patients with microcytic anemia owing to iron deficiency. Hyperbaric oxygen is an option for alternative rescue therapy. Most patients with chronic anemia may be discharged with follow-up if hemodynamically stable.
https://ift.tt/2y3BXKI
The Oncologic Emergency Medicine Fellowship
The United States cancer population is growing and is projected to grow further. The current cancer population has a high rate of emergency department admission. Further training about oncologic emergencies may be needed and would ideally strive to care for the whole patient, including sequelae of the malignancy, progressive disease, symptom control, adverse effects of treatment, and palliative care. The James Cancer Hospital at The Ohio State University Wexner Medical Center and The University of Texas MD Anderson Cancer Center fellowship training programs in oncologic emergency medicine are described.
https://ift.tt/2JI1pqy
Modified technique for imaging the wrist and elbow in obese and claustrophobic patients using a non-open standard MRI scanner
Abstract
Objective
It is challenging to image extremely obese and claustrophobic patients using a standard, non-open, magnetic resonance imaging (MRI) scanner. On the other hand, installing an additional upright or open MRI scanner may not be cost-effective for most practices. Our technique with a patient in a sitting or standing position behind the standard MRI scanner may be helpful in the MR examination of the wrist/elbow in these patients using a standard wrist/elbow coil.
Material and methods
We performed wrist and elbow MRI of extremely obese and claustrophobic patients by using our modified technique with the patient sitting or standing outside the standard non-open MRI scanner. A total number of 20 cases with the following diagnosis were examined: triquetral and scaphoid bone contusions and fractures, scapholunate ligament tears, triangular fibrocartilage complex tear, and biceps tear.
Results
Comparison of image quality for diagnostic information between the standard technique and our technique showed no significant difference, which is necessary for making the diagnosis.
Conclusions
Our technique enables wrist and elbow imaging of extremely obese and claustrophobic patients who cannot otherwise be imaged using a standard MRI scanner without compromising the image quality that is essential for making a diagnosis.
https://ift.tt/2MlfbkP
Correction to: GLP-I secretion in healthy and diabetic Wistar rats in response to aqueous extract of Momordica charantia
Following publication of the original article [1], the authors reported that there was an error in the acknowledgements.
https://ift.tt/2y67ATZ
Relationship between the geometry patterns of vertebrobasilar artery and atherosclerosis
The plaques at the dorsal or lateral wall of basilar artery (BA) are associated with pontine infarcts. We sought to explore the correlations between vertebrobasilar artery geometry and BA plaque locations.
https://ift.tt/2yciLLc
Correction to: Case series of Creutzfeldt-Jakob disease in a third-level hospital in Quito
Following publication of the original article [1], Andrés Damián Ortega Heredia requested that his name be corrected from
https://ift.tt/2l5luML
Biotin-based Pulldown Assay to Validate mRNA Targets of Cellular miRNAs
https://ift.tt/2l8ZErH
Deposition of Porous Sorbents on Fabric Supports
https://ift.tt/2y50Plt
Active Failures Seen in Proper Use of Personal Protective Equipment
TUESDAY, June 12, 2018 -- Active failures frequently occur in infectious agent transmission-based precautions, including personal protective equipment (PPE) use, according to a study published online June 11 in JAMA Internal Medicine. Sarah L....
https://ift.tt/2HH9n1B
Increase in Global Cancer Incidence, Drop in Death Rates
TUESDAY, June 12, 2018 -- Worldwide, cancer cases increased by 28 percent from 2006 to 2016, according to a study published online June 2 in JAMA Oncology. Christina Fitzmaurice, M.D., M.P.H., from the University of Washington in Seattle, and...
https://ift.tt/2JMQ4cg
Female Teens, Young Adults Not Getting Enough Exercise
TUESDAY, June 12, 2018 -- Female adolescents and young adults are not meeting the recommended guidelines for physical activity, according to a study published online June 11 in JAMA Pediatrics. Sarah Armstrong, M.D., from Duke University in Durham,...
https://ift.tt/2LKp8XS
Adverse Change in Employment Post-MI Tied to Worse Outcomes
TUESDAY, June 12, 2018 -- Patients with an adverse change in employment after myocardial infarction (MI) have increased likelihood of worse outcomes, according to a study published online June 12 in Circulation: Cardiovascular Quality and...
https://ift.tt/2JMQ1x6
Most Infants and Toddlers Consume Added Sugar
TUESDAY, June 12, 2018 -- Most infants and toddlers aged 6 to 23 months consume added sugar, according to a study presented during Nutrition 2018, the annual meeting of the American Society for Nutrition, held from June 9 to 12 in Boston. Kirsten...
https://ift.tt/2JMPYBq
APAGBI: Teens 13+ Should Be Assessed for VTE Prophylaxis
TUESDAY, June 12, 2018 -- In the perioperative period, post-pubertal adolescents should be assessed for venous thromboembolism (VTE) prophylaxis because of their slightly elevated risk, according to a special article from the Association of...
https://ift.tt/2HMlmek
Long-Term Type 1 Diabetes Associated With Cognitive Decline
TUESDAY, June 12, 2018 -- Both patients with type 1 and patients with type 2 diabetes show overall worse cognition than people without diabetes, according to a study published online June 5 in Diabetes Care. Gail Musen, Ph.D., from Harvard...
https://ift.tt/2JNp783
Eleven tips for white spots on teeth
Having white spots on your teeth can be undesirable, but they are rarely a serious medical concern. Possible reasons for them include poor dental hygiene and eating too many acidic or sugary foods. Here, we look at the most likely causes of white spots on teeth and give you 11 tips for treating and preventing them.
https://ift.tt/2l6TYyF
Neoadjuvant chemotherapy response influences outcomes in non‐colorectal, non‐neuroendocrine liver metastases
BJS, EarlyView.
https://ift.tt/2t3cprB
Magnetic resonance tumour regression grade and pathological correlates in patients with rectal cancer
BJS, EarlyView.
https://ift.tt/2l39w6i
Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling
Clinical and Translational Science, EarlyView.
https://ift.tt/2Jx4Nsf
Anisomycin Activates Utrophin Upregulation Through a p38 Signaling Pathway
Clinical and Translational Science, EarlyView.
https://ift.tt/2ybG1sm
Zygotic Fluorescence Recovery After Photo-bleaching Analysis for Chromatin Looseness That Allows Full-term Development
https://ift.tt/2JEqrH6
RNA interference targeting CD147 inhibits metastasis and invasion of human breast cancer MCF-7 cells by downregulating MMP-9/VEGF expression
https://ift.tt/2LM3hzn
Disturbances of spatial reference frame and postural asymmetry after a chronic stroke
Abstract
Asymmetrical postural behaviors are frequently observed after a stroke. They are due in part to the sensorimotor deficit, but they could also be related to a disorder of the representation of the body in space. The objective was to determine whether the asymmetrical postural behaviors of chronic stroke patients are related with a disruption of the perception of spatial frame. 30 chronic stroke patients (mean age 60.3 year ± 10, mean delay post-stroke 4.78 year ± 3), 15 patients with right brain damage (RBD) and 15 patients with left brain damage (LBD), and 20 healthy subjects participated in the study. Postural asymmetry was detected by the evaluation of body weight repartition on a force platform (weight body asymmetry) and was related to the longitudinal body axis (LBA) and the subjective straight ahead (SSA) (egocentric space representation) and to the subjective visual vertical (SVV) (allocentric space representation) by a multivariate analysis of variance adjusted with motor function and sensitivity as covariables. Both patients with RBD (35% ± 8) and LBD (39% ± 4) had body weight asymmetry and there was still space misperception at this stage of recovery, especially in the RBD group. WBA was related to LBA when considering both patients with RBD and LBD (p = 0.03). However, this relation was dependent on the side of the lesion (p = 0.0006) with a stronger relation in the RBD group (0.01). No relation with WBA was found neither with SSA (p = 0.58) nor with SVV (p = 0.47). This study pointed out a strong relationship between disturbance in the perception of the longitudinal body axis and postural asymmetry in chronic strokes, and especially within the RBD group. Conversely, no other spatial perturbations seemed to be involved in this particular postural behavior.
https://ift.tt/2Mjcv78
A Quantitative Dot Blot Assay for AAV Titration and Its Use for Functional Assessment of the Adeno-associated Virus Assembly-activating Proteins
https://ift.tt/2yc2Hcm
Finite element analysis of the influence of three‐joint spinal complex on the change of the intervertebral disc bulge and height
International Journal for Numerical Methods in Biomedical Engineering, EarlyView.
https://ift.tt/2t1Uxgz
Few‐view CT reconstruction with group‐sparsity regularization
International Journal for Numerical Methods in Biomedical Engineering, EarlyView.
https://ift.tt/2l3HrvN
Issue Information
International Journal for Numerical Methods in Biomedical Engineering, Volume 34, Issue 6, June 2018.
https://ift.tt/2y4Bnwr
Cover Image
International Journal for Numerical Methods in Biomedical Engineering, Volume 34, Issue 6, June 2018.
https://ift.tt/2l6pRqQ
An “Omics” Approach for Lipid Oxidation in Foods: The Case of Free Fatty Acids in Bulk Purified Olive Oil
European Journal of Lipid Science and Technology, EarlyView.
https://ift.tt/2JJ7G5C
Enzymatic Interesterification of Heterotrophic Microalgal Oil with Rapeseed Oil to Decrease the Levels of Tripalmitin
European Journal of Lipid Science and Technology, EarlyView.
https://ift.tt/2Jx4cHl
Influence of apical enlargement on the repair of apical periodontitis in rats
International Endodontic Journal, EarlyView.
https://ift.tt/2sTD8HN
Release of TGF‐β1 into root canals with various final irrigants in regenerative endodontics: an in vitro analysis
International Endodontic Journal, EarlyView.
https://ift.tt/2t1gRXK
Issue Information
International Endodontic Journal, Volume 51, Issue 7, Page i-iii, 715, July 2018.
https://ift.tt/2y2WQ99
External cervical resorption: part 2 – management
International Endodontic Journal, EarlyView.
https://ift.tt/2l6fsMc
Substance P and Calcitonin gene‐related peptide expression in human periodontal ligament after root canal preparation with Reciproc Blue, WaveOne Gold, XP EndoShaper and hand files
International Endodontic Journal, EarlyView.
https://ift.tt/2l2ZCl8
An analysis of the timing and materials associated with pulp disease following restorative dental treatment
International Endodontic Journal, EarlyView.
https://ift.tt/2t3mdSi
Clinical implication of FMR1 intermediate alleles in a Spanish population
Clinical Genetics, Volume 94, Issue 1, Page 153-158, July 2018.
https://ift.tt/2JDa79G
Discovery of 4 exonic and 1 intergenic novel susceptibility loci for leprosy
Clinical Genetics, EarlyView.
https://ift.tt/2JD9YTG
Association between glutathione S‐transferase gene M1 and T1 polymorphisms and chronic obstructive pulmonary disease risk: A meta‐analysis
Clinical Genetics, EarlyView.
https://ift.tt/2JtbZFQ
Bilateral cerebellar cysts and cerebral white matter lesions with cortical dysgenesis: Expanding the phenotype of LAMB1 gene mutations
Clinical Genetics, EarlyView.
https://ift.tt/2JEOC8q
Overlapping but distinct roles for NOTCH receptors in human cardiovascular disease
Clinical Genetics, EarlyView.
https://ift.tt/2MkfGLT
Further audiovestibular characterization of DFNB77, caused by deleterious variants in LOXHD1, and investigation into the involvement of Fuchs corneal dystrophy
Clinical Genetics, EarlyView.
https://ift.tt/2y3Yibb
Pathogenetic implication of fusion genes in acute promyelocytic leukemia and their diagnostic utility
Clinical Genetics, EarlyView.
https://ift.tt/2MkGvja
Genetic analysis of adult leukoencephalopathy patients using a custom‐designed gene panel
Clinical Genetics, EarlyView.
https://ift.tt/2y5IFjB
Metagenomic insights into diazotrophic communities across Arctic glacier forefields
https://ift.tt/2l7SIv8
Birds, feather-degrading bacteria and preen glands: the antimicrobial activity of preen gland secretions from turkeys (Meleagris gallopavo) is amplified by keratinase
https://ift.tt/2y8c5xy
Patient information needs in upper gastrointestinal cancer: what patients and their families want to know
ANZ Journal of Surgery, EarlyView.
https://ift.tt/2sRKMSW
Inflammatory calcified de‐differentiated liposarcoma of the anterior mediastinum: an unusual case
ANZ Journal of Surgery, EarlyView.
https://ift.tt/2LIO7ux
Pattern of care for cancer of the oesophagus in a western population
ANZ Journal of Surgery, EarlyView.
https://ift.tt/2LJD0BP
Jejunal angiosarcoma: a rare cause of obscure gastrointestinal bleeding with successful resection after enteroscopic localization
ANZ Journal of Surgery, EarlyView.
https://ift.tt/2sQw7HG
Comparison of lipase and amylase for diagnosing post‐operative pancreatic fistulae
ANZ Journal of Surgery, EarlyView.
https://ift.tt/2LGHkBJ
Single‐ and multiple‐dose escalation study to assess pharmacokinetics, pharmacodynamics and safety of oral esaxerenone in healthy Japanese subjects
British Journal of Clinical Pharmacology, EarlyView.
https://ift.tt/2y8cqjO
Gaps in predicting clinical doses for cannabinoids therapy: Overview of issues for pharmacokinetics and pharmacodynamics modelling
British Journal of Clinical Pharmacology, EarlyView.
https://ift.tt/2MiCueV
Comment on ‘Genotype‐guided warfarin dosing versus conventional dosing strategies: a systematic review and meta‐analysis of randomized clinical trials’ by Tse et al.
British Journal of Clinical Pharmacology, EarlyView.
https://ift.tt/2Jx2bLh
The impact of ileal pouch‐anal anastomosis on graft survival following liver transplantation for primary sclerosing cholangitis
Alimentary Pharmacology &Therapeutics, EarlyView.
https://ift.tt/2t3wDkO
Issue Information
Alimentary Pharmacology &Therapeutics, Volume 48, Issue 1, Page 1-3, July 2018.
https://ift.tt/2MiB8AO
Editorial: an argument for low‐dose thiopurine allopurinol combination use as first‐line therapy in inflammatory bowel disease
Alimentary Pharmacology &Therapeutics, Volume 48, Issue 1, Page 97-98, July 2018.
https://ift.tt/2JC9bSV
Letter: all or nothing—placebo effects in a non‐drug clinical trial in IBS
Alimentary Pharmacology &Therapeutics, Volume 48, Issue 1, Page 105-106, July 2018.
https://ift.tt/2sRJur4
Editorial: Helicobacter pylori resistance and sequential therapy—authors’ reply
Alimentary Pharmacology &Therapeutics, Volume 48, Issue 1, Page 96-97, July 2018.
https://ift.tt/2JEKOnE
Editorial: HBsAg serum levels in HBeAg‐negative chronic HBV infection—is it a matter of genotype?
Alimentary Pharmacology &Therapeutics, Volume 48, Issue 1, Page 102-103, July 2018.
https://ift.tt/2sS43DT
Editorial: HBsAg serum levels in HBeAg‐negative chronic HBV infection—is it a matter of genotype? Authors’ reply
Alimentary Pharmacology &Therapeutics, Volume 48, Issue 1, Page 103-104, July 2018.
https://ift.tt/2t2uo1r
Editorial: transplantation in the setting of acute‐on‐chronic liver failure—calculating chances. Authors’ reply
Alimentary Pharmacology &Therapeutics, Volume 48, Issue 1, Page 100-101, July 2018.
https://ift.tt/2MiARhg
Editorial: Helicobacter pylori resistance and sequential therapy
Alimentary Pharmacology &Therapeutics, Volume 48, Issue 1, Page 95-96, July 2018.
https://ift.tt/2t2ugyZ
Letter: can the overall gastrointestinal safety of celecoxib be extended to all COX‐2‐selective agents?
Alimentary Pharmacology &Therapeutics, Volume 48, Issue 1, Page 108-110, July 2018.
https://ift.tt/2Mmw7ap
Editors’ declarations of interest
Alimentary Pharmacology &Therapeutics, Volume 48, Issue 1, Page 4-4, July 2018.
https://ift.tt/2JFqqTs
Letter: it is time to adopt new objective parameters to accurately identify patients with functional heartburn
Alimentary Pharmacology &Therapeutics, Volume 48, Issue 1, Page 107-108, July 2018.
https://ift.tt/2MiAJyi
Editorial: an argument for low‐dose thiopurine allopurinol combination use as first‐line therapy in inflammatory bowel disease—authors’ reply
Alimentary Pharmacology &Therapeutics, Volume 48, Issue 1, Page 98-99, July 2018.
https://ift.tt/2t2GjMG
Letter: all or nothing—placebo effects in a non‐drug clinical trial in IBS. Authors’ reply
Alimentary Pharmacology &Therapeutics, Volume 48, Issue 1, Page 106-107, July 2018.
https://ift.tt/2MnuU2H
Editorial: transplantation in the setting of acute‐on‐chronic liver failure—calculating chances
Alimentary Pharmacology &Therapeutics, Volume 48, Issue 1, Page 99-100, July 2018.
https://ift.tt/2JDULBA
Review article: Asia‐Pacific consensus recommendations on endoscopic tissue acquisition for biliary strictures
Alimentary Pharmacology &Therapeutics, EarlyView.
https://ift.tt/2MiAzXI
Risk of post‐operative surgical site infections after vedolizumab vs anti‐tumour necrosis factor therapy: a propensity score matching analysis in inflammatory bowel disease
Alimentary Pharmacology &Therapeutics, EarlyView.
https://ift.tt/2JGdHjl
A Scientist's Guide to Impactful Science Communication: A Priori Goals, Collaborative Assessment, and Engagement with Youth
https://ift.tt/2LJrYME
Primary Cilia Reconsidered in the Context of Ciliopathies: Extraciliary and Ciliary Functions of Cilia Proteins Converge on a Polarity theme?
BioEssays, EarlyView.
https://ift.tt/2LL4xTo
Dietary Micronutrients Promote Neuronal Differentiation by Modulating the Mitochondrial‐Nuclear Dialogue
BioEssays, EarlyView.
https://ift.tt/2HHODGQ
Editorial Note Referring to: An Inversion in the Wiring of an Intercellular Signal: Evolution of Wnt Signaling in the Nematode Vulva
BioEssays, EarlyView.
https://ift.tt/2JPpGye
Pentylenetetrazole-Induced Kindling Mouse Model
This protocol describes a method of chemical kindling with pentylenetetrazole and provides a mouse model of epilepsy. This protocol can also be used to investigate vulnerability to seizure induction and pathogenesis after epileptic seizures in mice.
https://ift.tt/2sY5LTe
Thermal oxidation and hydrofluoric acid treatment on the sandblasted implant surface: A histologic histomorphometric and biomechanical study
Clinical Oral Implants Research, EarlyView.
https://ift.tt/2MfzQqt
Dental implants placed in severely atrophic jaws reconstructed with autogenous calvarium, bovine bone mineral, and collagen membranes: A 3‐ to 19‐year retrospective follow‐up study
Clinical Oral Implants Research, EarlyView.
https://ift.tt/2t1Nl43
Reposition of the bone plate over the antrostomy in maxillary sinus augmentation: A histomorphometric study in rabbits
Clinical Oral Implants Research, EarlyView.
https://ift.tt/2sRe44i
Long‐term psychological and educational outcomes for survivors of neuroblastoma: A report from the Childhood Cancer Survivor Study
Cancer, EarlyView.
https://ift.tt/2t1H0FP
Examining urban and rural differences in perceived timeliness of care among cancer patients: A SEER‐CAHPS study
Cancer, EarlyView.
https://ift.tt/2l566jJ
Reply to The persistent uncertainty of when to recommend allogeneic stem cell transplantation in follicular lymphoma
Cancer, EarlyView.
https://ift.tt/2y5BB6n
The persistent uncertainty of when to recommend allogeneic stem cell transplantation in follicular lymphoma
Cancer, EarlyView.
https://ift.tt/2l6rl4I
Association of low‐activity ALDH2 and alcohol consumption with risk of esophageal cancer in Chinese adults: A population‐based cohort study
International Journal of Cancer, EarlyView.
https://ift.tt/2MkI8NL
A prospective evaluation of plasma polyphenol levels and colon cancer risk
International Journal of Cancer, EarlyView.
https://ift.tt/2y4qzOT
T cells and ILC2s are major effector cells in influenza‐induced exacerbation of allergic airway inflammation in mice
European Journal of Immunology, EarlyView.
https://ift.tt/2JQdqh1
The bone marrow is not only a primary lymphoid organ: The critical role for T lymphocyte migration and housing of long‐term memory plasma cells
European Journal of Immunology, EarlyView.
https://ift.tt/2HJ1Dfi
Front cover story: Eur. J. Immunol. 6'18
European Journal of Immunology, Volume 48, Issue 6, June 2018.
https://ift.tt/2JN67Xq
Journal roundup
European Journal of Immunology, Volume 48, Issue 6, Page 895-895, June 2018.
https://ift.tt/2LJ85VX
Contents: Eur. J. Immunol. 6'18
European Journal of Immunology, Volume 48, Issue 6, Page 889-892, June 2018.
https://ift.tt/2JPv3O6
In this issue
European Journal of Immunology, Volume 48, Issue 6, Page 893-894, June 2018.
https://ift.tt/2LHRNN8
Impressum
European Journal of Immunology, Volume 48, Issue 6, Page 1085-1085, June 2018.
https://ift.tt/2JPAI6A
EFIS on Tour ‐ getting to know our members
European Journal of Immunology, Volume 48, Issue 6, Page 896-897, June 2018.
https://ift.tt/2HGKumE
Editorial Board: Eur. J. Immunol. 6'18
European Journal of Immunology, Volume 48, Issue 6, June 2018.
https://ift.tt/2JMCVzW
Microglial MHC class II is dispensable for experimental autoimmune encephalomyelitis and cuprizone‐induced demyelination
European Journal of Immunology, EarlyView.
https://ift.tt/2LJog5G
Serotonin decreases the production of Th1/Th17 cytokines and elevates the frequency of regulatory CD4+ T‐cell subsets in multiple sclerosis patients
European Journal of Immunology, EarlyView.
https://ift.tt/2JMXUCE
Aberrant learning in Parkinson's disease: A neurocomputational study on bradykinesia
European Journal of Neuroscience, EarlyView.
https://ift.tt/2y4JGIu
Behavioural state‐specific neurons in the mouse medulla involved in sleep‐wake switching
European Journal of Neuroscience, EarlyView.
https://ift.tt/2Jxod0o
A journey into the retina: Müller glia commanding survival and death
European Journal of Neuroscience, EarlyView.
https://ift.tt/2y4JwRo
Neuroplasticity in stroke recovery. The role of microglia in engaging and modifying synapses and networks
European Journal of Neuroscience, EarlyView.
https://ift.tt/2JvsS2B
Vestibulo‐cortical hemispheric dominance: The link between anxiety and the vestibular system?
European Journal of Neuroscience, EarlyView.
https://ift.tt/2JAWUy2
Emergency Department Discharge of Pulmonary Embolus Patients
Academic Emergency Medicine, EarlyView.
https://ift.tt/2LMez6r
Financial Viability of Emergency Department Observation Unit Billing Models
Academic Emergency Medicine, EarlyView.
https://ift.tt/2JMClSM
Realization of In‐Plane p–n Junctions with Continuous Lattice of a Homogeneous Material
Advanced Materials, EarlyView.
https://ift.tt/2Mnkgcf
Protein Toxin Chaperoned by LRP‐1‐Targeted Virus‐Mimicking Vesicles Induces High‐Efficiency Glioblastoma Therapy In Vivo
Advanced Materials, EarlyView.
https://ift.tt/2JAMt1K
Metal–Organic‐Framework‐Based Catalysts for Photoreduction of CO2
Advanced Materials, EarlyView.
https://ift.tt/2y3HaCp
Pistachio‐Shuck‐Like MoSe2/C Core/Shell Nanostructures for High‐Performance Potassium‐Ion Storage
Advanced Materials, EarlyView.
https://ift.tt/2JuTVuY
Black Arsenic: A Layered Semiconductor with Extreme In‐Plane Anisotropy
Advanced Materials, EarlyView.
https://ift.tt/2JCTQ4A
Increased Exciton Delocalization of Polymer upon Blending with Fullerene
Advanced Materials, EarlyView.
https://ift.tt/2t6pS1Y
Full Electric Control of Exchange Bias at Room Temperature by Resistive Switching
Advanced Materials, EarlyView.
https://ift.tt/2l49ICl
Lead‐Chalcogenide Colloidal‐Quantum‐Dot Solids: Novel Assembly Methods, Electronic Structure Control, and Application Prospects
Advanced Materials, EarlyView.
https://ift.tt/2JHnqpD
Room‐Temperature Triple‐Ligand Surface Engineering Synergistically Boosts Ink Stability, Recombination Dynamics, and Charge Injection toward EQE‐11.6% Perovskite QLEDs
Advanced Materials, EarlyView.
https://ift.tt/2MnjVGv
Photoelectric Detectors Based on Inorganic p‐Type Semiconductor Materials
Advanced Materials, EarlyView.
https://ift.tt/2y3GWLz
Ferroelectric and Piezoelectric Effects on the Optical Process in Advanced Materials and Devices
Advanced Materials, EarlyView.
https://ift.tt/2MkmvgA
Single Tungsten Atoms Supported on MOF‐Derived N‐Doped Carbon for Robust Electrochemical Hydrogen Evolution
Advanced Materials, EarlyView.
https://ift.tt/2y7vcHY
A 3D Magnetic Hyaluronic Acid Hydrogel for Magnetomechanical Neuromodulation of Primary Dorsal Root Ganglion Neurons
Advanced Materials, EarlyView.
https://ift.tt/2JAM67m
New Frontiers in Electron Beam–Driven Chemistry in and around Graphene
Advanced Materials, EarlyView.
https://ift.tt/2JCTrPC
The Organic Crystalline Materials of Vision: Structure–Function Considerations from the Nanometer to the Millimeter Scale
Advanced Materials, EarlyView.
https://ift.tt/2MkmhGg
Ultrafine Co Nanoparticles Encapsulated in Carbon‐Nanotubes‐Grafted Graphene Sheets as Advanced Electrocatalysts for the Hydrogen Evolution Reaction
Advanced Materials, EarlyView.
https://ift.tt/2y3GGw5
Phosphorene/ZnO Nano‐Heterojunctions for Broadband Photonic Nonvolatile Memory Applications
Advanced Materials, EarlyView.
https://ift.tt/2Mmc500
Unraveling the Water Impermeability Discrepancy in CVD‐Grown Graphene
Advanced Materials, EarlyView.
https://ift.tt/2JCThru
Rewritable Optical Memory Through High‐Registry Orthogonal Upconversion
Advanced Materials, EarlyView.
https://ift.tt/2MmbYS8
Development of a novel humanoid‐robot simulator for endoscope with pharyngeal reflex and real‐life responses
Digestive Endoscopy, EarlyView.
https://ift.tt/2JyojEK
Japan NBI Expert Team classification: Narrow‐band imaging magnifying endoscopic classification of colorectal tumors
Digestive Endoscopy, EarlyView.
https://ift.tt/2y11dBo
Epstein–Barr virus positivity among surgically resected intramucosal gastric cancer
Digestive Endoscopy, EarlyView.
https://ift.tt/2JzVwQ8
Crossed‐clip strangulation for the management of small intestinal polyps in patients with Peutz‐Jeghers syndrome
Digestive Endoscopy, EarlyView.
https://ift.tt/2JDpNcR
The clitoral activation paradox — Claimed outcomes from different methods of its stimulation
Clinical Anatomy, June 2018.
https://ift.tt/2t3pyRg
The fasciacytes: A new cell devoted to fascial gliding regulation
Clinical Anatomy, June 2018.
https://ift.tt/2MizVto
The role of mTOR in ovarian cancer, polycystic ovary syndrome and ovarian aging
Clinical Anatomy, June 2018.
https://ift.tt/2JFsaMg
Chronic liver injury promotes hepatocarcinoma cell seeding and growth, associated with infiltration by macrophages
Cancer Science, EarlyView.
https://ift.tt/2y5uKd9
HSPC159 promotes proliferation and metastasis by inducing epithelial‐mesenchymal transition and activating the PI3K/Akt pathway in breast cancer
Cancer Science, EarlyView.
https://ift.tt/2Jvr0Hb
Stromal barriers to nanomedicine penetration in the pancreatic tumor microenvironment
Cancer Science, EarlyView.
https://ift.tt/2JFrV3O
Increase in incidental detection of thyroid cancer in Osaka, Japan
Cancer Science, EarlyView.
https://ift.tt/2JvqCZf
Argininosuccinate synthase 1 and periportal gene expression in sonic hedgehog hepatocellular adenomas
Hepatology, EarlyView.
https://ift.tt/2JGZNO2
Acute hepatitis B virus infection in humanized chimeric mice has multiphasic viral kinetics
Hepatology, EarlyView.
https://ift.tt/2JxV315
Beyond the ‘Reading Wars’: How the Science of Reading Can Improve Literacy
A new scientific report from an international team of psychological researchers aims to resolve the so-called "reading wars," emphasizing the importance of teaching phonics in establishing fundamental reading skills in early childhood. The report, published in in Psychological Science in the Public Interest, a journal of the Association for Psychological Science, shows how early phonics skills are advanced with a rich reading curriculum throughout the school years.
Scientists Anne Castles (Macquarie University), Kathleen Rastle (Royal Holloway University of London), and Kate Nation (University of Oxford) report their conclusions as part of a thorough, evidence-based account of how children learn to read. They synthesize findings from more than 300 research studies, book chapters, and academic journal articles published across a variety of scientific fields.
"We decided to bring this knowledge together in one place to provide an accessible overview," Nation says. "We didn't want it to be buried in the scientific literature, we wanted it to be useful to teachers charged with the vital task of teaching children to read."
For several decades, the "reading wars" have been waged between teachers, parents, and policymakers who champion a phonics-based approach (teaching children the sounds that letters make) and those who support a "whole-language" approach (focused on children discovering meaning in a literacy-rich environment).
"Writing is a code for spoken language, and phonics provides instruction for children in how to crack that code," says Castles. "Phonics is an essential basis for becoming a good reader, but it isn't enough on its own — one aim of our review was to describe the other key ingredients that must be combined with phonics to support good reading development."
To acquire sophisticated literacy skills, for example, children must progress from identifying individual sounds to recognizing whole words. They must also be able to pull forth the meaning of different words quickly within a particular context in order to comprehend a whole unit of text, whether it's a sentence, a paragraph, or an entire page.
Although teachers, parents, and policymakers recognize literacy as an essential skill that all children should learn, existing policies and practices often fail to incorporate the most effective strategies for learning and teaching reading. As a result, low literacy remains a pressing issue in developed and developing nations around the world.
"We have a really strong scientific understanding of how children learn to read, and there is no longer any need for 'reading wars,'" says Rastle. "Our review describes this evidence base, and provides concrete recommendations for drawing on it in the classroom."
In a commentary accompanying the report, psychological scientist Rebecca Treiman (Washington University in St. Louis) dismantles two common misconceptions that often stymy evidence-based approaches to reading instruction: that reading to children teaches them how to read and that children learn to read though independent discovery. The new report provides critical insight, Treiman says, because it highlights the specific processes by which early phonics instruction allows children to gain understanding and reading experience over time.
"Literacy opens up knowledge, opportunity, and enjoyment. Building it requires good instruction, solid foundations in vocabulary and language comprehension, and extensive reading practice," Castles, Rastle, and Nation note. "By taking advantage of the strong evidence base around what helps children learn to read, we can support more children to go on to become confident, skilled readers."
The report was supported by the Australian Research Council Centre of Excellence in Cognition and its Disorders, the Economic and Social Research Council, and The Leverhulme Trust.
The full report and accompanying commentary are available online:
Report: Ending the "Reading Wars": Reading acquisition from novice to expert
Anne Castles, Kathleen Rastle, Kate Nation
Commentary: What research tells us about reading instruction
Rebecca Treiman
https://ift.tt/2HFhNGt
A probiotic modulates the microbiome and immunity in multiple sclerosis
Annals of Neurology, EarlyView.
https://ift.tt/2JI2PSd
Issue Information
Histopathology, Volume 73, Issue 1, Page 180-184, July 2018.
https://ift.tt/2Mkzxut
Gleason score assignment is the sole responsibility of the pathologist
Histopathology, Volume 73, Issue 1, Page 5-7, July 2018.
https://ift.tt/2Mkzj6B
Interobserver reliability of histopathological features for distinguishing between cutaneous polyarteritis nodosa and superficial thrombophlebitis
Histopathology, EarlyView.
https://ift.tt/2JGXY3E
PD‐L1 expression in tumour‐infiltrating lymphocytes is a poor prognostic factor for primary acral melanoma patients
Histopathology, EarlyView.
https://ift.tt/2MmiBUd
The American Cancer Society public health statement on eliminating combustible tobacco use in the United States
CA: A Cancer Journal for Clinicians, EarlyView.
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Correction to: Comprehensive Registry of Esophageal Cancer in Japan, 2011
In the original publication of the article, the below name of institutions were not included in the table of Institution-registered cases in 2011.
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Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells
Type 2 immunity underpins diverse processes central to tissue homeostasis, allergic inflammation, and anti-helminth immunity. Halim et al. demonstrate that the local expansion of Th2 and Treg cells in response to the alarmin IL-33 is dependent on the expression of the costimulatory molecule OX40L by type 2 innate lymphoid cells (ILC2s), revealing a central role for the IL-33-ILC2-OX40L pathway in the orchestration of type 2 immunity.
https://ift.tt/2JMPZoQ
OncoArray Links Dozens of DNA Variants to Risk for Common Cancers
Researchers with the NCI-supported GAME-ON initiative and OncoArray Network are publishing studies identifying dozens of new genetic variants associated with the risk for developing some of the most common cancers.
https://ift.tt/2sXeEh1
Mcl-1 phosphorylation without degradation mediates sensitivity to HDAC inhibitors by liberating BH3-only proteins
Mcl-1, a pro-survival Bcl-2 family protein, is frequently overexpressed in cancer cells and plays a critical role in therapeutic resistance. It is well known that anti-cancer agents induce phosphorylation of Mcl-1, which promotes its binding to E3 ubiquitin ligases and subsequent proteasomal degradation and apoptosis. However, other functions of Mcl-1 phosphorylation in cancer cell death have not been well characterized. In this study, we show in colon cancer cells that histone deacetylase inhibitors (HDACi) induce GSK3β-dependent Mcl-1 phosphorylation, but not degradation or downregulation. The in vitro and in vivo anticancer effects of HDACi were dependent on Mcl-1 phosphorylation and were blocked by genetic knock-in (KI) of a Mcl-1 phosphorylation site mutant. Phosphorylation-dead Mcl-1 maintained cell survival by binding and sequestering BH3-only Bcl-2 family proteins PUMA, Bim, and Noxa, which were upregulated and necessary for apoptosis induction by HDACi. Resistance to HDACi mediated by phosphorylation-dead Mcl-1 was reversed by small-molecule Mcl-1 inhibitors that liberated BH3-only proteins. These results demonstrate a critical role of Mcl-1 phosphorylation in mediating HDACi sensitivity through a novel and degradation-independent mechanism. These results provide new mechanistic insights on how Mcl-1 maintains cancer cell survival and suggest that Mcl-1-targeting agents are broadly useful for overcoming therapeutic resistance in cancer cells.
https://ift.tt/2sRpHIv
Integrative genome-wide analysis of long noncoding RNAs in diverse immune cell types of melanoma patients
Genome-wide identification and characterization of long non-coding RNAs (lncRNAs) in individual immune cell lineages helps us better understand the driving mechanisms behind melanoma and advance personalized patient treatment. To elucidate the transcriptional landscape in diverse immune cell types of peripheral blood cells (PBC) in stage IV melanoma, we used whole transcriptome RNA sequencing to profile lncRNAs in CD4+, CD8+, and CD14+ PBC from 132 patient samples. Our integrative computational approach identified 27,625 expressed lncRNAs, 2,744 of which were novel. Both T cells (i.e., CD4+ and CD8+ PBC) and monocytes (i.e., CD14+ PBC) exhibited differential transcriptional expression profiles between melanoma patients and healthy subjects. Cis- and trans-level co-expression analysis suggested that lncRNAs are potentially involved in many important immune-related pathways and the programmed cell death receptor 1 (PD-1) checkpoint pathways. We also identified 9 gene co-expression modules significantly associated with melanoma status, all of which were significantly enriched for three mRNA translation processes. Age and melanoma traits closely correlated with each other, implying that melanoma contains age-associated immune changes. Our computational prediction analysis suggests that many cis- and trans-regulatory lncRNAs could interact with multiple transcriptional and post-transcriptional regulatory elements in CD4+, CD8+, and CD14+ PBC, respectively. These results provide novel insights into the regulatory mechanisms involving lncRNAs in individual immune cell types in melanoma and can help expedite cell type-specific immunotherapy treatments for such diseases.
https://ift.tt/2LFMXA3
Type I Chiari Malformation Presenting in an Adult
Description
Type I Chiari malformations (CMs) is an acquired or congenital disorder characterised by the presence of the cerebellar tonsils at 5 mm or below of the spinal canal, which can result in abnormal cerebrospinal fluid flow and produce headaches, syrinx or hydrocephalus. CMs are still considered an uncommon disease with a prevalence in the USA of less than 1%.1 2 We present a 44-year-old man with no medical history who presented to the emergency department complaining of nausea, vomiting, vertigo and a 2-day history of headaches exacerbated with Valsalva manoeuvres. He was initially admitted with a working diagnosis of ischaemic stroke and underwent a CT scan of the brain, which was unremarkable. Further work-up with brain MRI disclosed incidental cerebellar herniation 6.5 mm below the foramen magnum (figure 1) and no abnormalities in spinal canal MRIs. The patient was treated symptomatically with oral...
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Marantic endocarditis: incidental infarcts leading to diagnosis of pancreatic cancer
Non-bacterial thrombotic endocarditis (NBTE) is a well-described phenomenon associated with malignancies due to hypercoaguable state. In the setting of pancreatic cancer, NBTE is more commonly diagnosed postmortem. We describe a case of a man who was diagnosed with pancreatic carcinoma after incidental finding of NBTE. Imaging incidentally revealed multiple strokes, bilateral renal and splenic infarcts, while subsequent workup for cardioembolic source demonstrated a 1.1x0.7 cm mitral valve vegetation. As multiple blood cultures were sterile and patient lacked clinical signs of infection, an underlying malignancy was suspected. CT abdomen demonstrated a dilated pancreatic duct, MRI showed a 2.8x2.2 cm pancreatic head mass. Endoscopic biopsy of the mass revealed pancreatic adenocarcinoma. Other than NBTE, there were no other clinical or laboratory findings to clearly suggest pancreatic cancer. Thus, incidental discovery of this mitral valve vegetation led to the diagnosis of pancreatic malignancy.
https://ift.tt/2MiCXOe
Herpes zoster with cutaneous dissemination: a rare presentation of an uncommon pathology in children
Herpes zoster, caused by varicella zoster virus (VZV) reactivation, affects mainly the adult population, although it can occur in children. This happens when primary infection (varicella) has occurred at a very young age or in immunocompromised patients. Complications are rare in healthy individuals. They include VZV cutaneous dissemination, which affects 2%–10% of immunocompromised patients.
We present a previously healthy child, with history of varicella during her first month of life, which presented at age 8 with a severe case of herpes zoster, complicated with cutaneous dissemination. Immunity study was unremarkable. Causes, management and follow-up are discussed.
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Central nervous system blast crisis of chronic myeloid leukaemia misdiagnosed as tubercular meningitis
Chronic Myeloid Leukaemia (CML) presenting with isolated Central Nervous System (CNS) blast crisis is an uncommon entity. A 22-year-old man, diagnosed with chronic phase CML in 2011 and was in haematological and cytogenetic remission until July 2016, had acute onset headache and vomiting with meningeal signs and was admitted elsewhere, investigated by brain imaging and cerebrospinal fluid (CSF) analysis and suspected to have tubercular meningitis, for which steroids and antitubercular medications were started. The patient's sensorium further deteriorated, and Ventriculoperitoneal shunt surgery was done for hydrocephalus by a neurosurgeon. After 2 months of the illness, he was admitted to our hospital with a persistent headache, vomiting and altered sensorium. CSF for cytospin confirmed myeloid blasts. He was still in haematological remission. So, a diagnosis of isolated CNS blast crisis was made. The patient was started on triple intrathecal chemotherapy and cranial radiotherapy. He had improvement with treatment and is still in remission.
https://ift.tt/2Mk9vYf
Resistant Gram-Negative Bacteria and Diagnostic Point-of-Care Options for the Field Setting during Military Operations
The spread of multidrug-resistant bacteria in resource-poor settings affects the military medical service in case of deployments of soldiers to war and crisis zones. Patients with war injuries are prone to colonization or infection with multidrug-resistant bacteria. Resistant Gram-negative bacteria play a dominant role in military wound infections. Problematic hygiene conditions on deployment facilitate exposition of soldiers with subsequent colonization. Although colonizing strains are frequently cleared from their hosts after returning from deployment, transmission to close contacts of the soldiers in the home country cannot be excluded and therapeutic options are reduced if colonization progresses to invasive infection. Since sophisticated culture-based diagnostic approaches are typically not available in the field setting on deployment, molecular rapid diagnostic test systems are an option for transmission control if the locally prevalent molecular resistance mechanisms are known. Efforts for global resistance surveillance can contribute to better understanding of resistance distribution and spread at deployment sites. This review summarizes experience of the military medical services with multidrug resistance on deployment and with the influx of resistant strains to the home country and discusses potential use of available molecular rapid test systems as an option for the field setting.
https://ift.tt/2t0GwzO
Moderate Fluid Shear Stress Could Regulate the Cytoskeleton of Nucleus Pulposus and Surrounding Inflammatory Mediators by Activating the FAK-MEK5-ERK5-cFos-AP1 Signaling Pathway
We first applied moderate fluid shear stress to nucleus pulposus cells. The correlation of AP-1 with type II collagen, proteoglycan, Cytokeratin 8 protein, MAP-1, MAP-2, and MAP-4 and the correlation of AP-1 with IL-1β, TNF-α, IL-6, IL-8, MIP-1, MCP-1, and NO were detected. Our results document that moderate fluid shear stress could activate the FAK-MEK5-ERK5-cFos-AP1 signaling pathway. AP1 could downregulate the construct factors of cytoskeleton such as type II collagen, proteoglycan, Cytokeratin 8 protein, MAP-1, MAP-2, and MAP-4 in nucleus pulposus cell after the fluid shear stress was loaded. AP1 could upregulate the inflammatory factors such as IL-1β, TNF-α, IL-6, IL-8, MIP-1, MCP-1, and NO in nucleus pulposus cell after the fluid shear stress was loaded. Taken together, our data suggested that moderate fluid shear stress may play an important role in the cytoskeleton of nucleus pulposus and surrounding inflammatory mediators by activating the FAK-MEK5-ERK5-cFos-AP1 signaling pathway, thereby affecting cell degeneration.
https://ift.tt/2sPOZGD
Sclerotic Bone Metastasis in Pulmonary Adenocarcinoma
Pulmonary adenocarcinoma is one of the major types of lung cancers in which metastasis is very common and it accounts approximately to one-third of all primary pulmonary cancers. Although a minority of patients with lung cancer are asymptomatic, which gets usually detected in routine chest radiography, most of the patients present with some symptoms. Lung cancer metastasis may occur virtually in every organ system. Patients with non-small-cell lung cancer commonly have extrathoracic metastases to the adrenal glands, liver, brain, bones, and lymph nodes at presentation. Approximately one-third of patients with lung cancer will present with symptoms related to extrathoracic spread. Metastasis to the bone is not uncommon in lung cancer; however, osteoblastic bone metastasis is very rare. Here we present a 30-year-old female diagnosed to have pulmonary adenocarcinoma with multiple sclerotic bony lesions in the vertebra.
https://ift.tt/2LEL7PK
How I perform sphincterotomy
Since 1973, endoscopic sphincterotomy has been one of the cornerstones in therapeutic endoscopic retrograde cholangiopancreatography (ERCP). However, the procedure adds to the overall risk of the ERCP procedure and the risk/benefit ratio must always be assessed carefully prior to performing the cut.
https://ift.tt/2l3aYFV
Su1435 FLUOROLESS SINGLE-STEP EUS-GUIDED GALLBLADDER DRAINAGE WITH CAUTERY-ENHANCED LUMEN-APPOSING METAL STENT: A MULTICENTER STUDY
Recently, a novel device has been utilized to drain pancreatic fluid collections using an EUS-guided biflanged fully covered self-expandable lumen-apposing metal stent (LAMS) with an electrocautery enhanced delivery system (cautery-enhanced LAMS: CE-LAMS). The aim of this study was to analyze the clinical effectiveness and safety of this novel device for treatment of acute cholecystitis in patients who are not surgical candidates.
https://ift.tt/2t5SIQ2
Frontmatter
Journal Name: Biological Chemistry
Volume: 399
Issue: 7
Pages: i-iv
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Highlight Issue ‘Molecular Basis of Life 2017’
Journal Name: Biological Chemistry
Volume: 399
Issue: 7
Pages: 621-622
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Regulation of LRRK2: insights from structural and biochemical analysis
Journal Name: Biological Chemistry
Volume: 399
Issue: 7
Pages: 637-642
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Oncogenic BRAFV600E drives expression of MGL ligands in the colorectal cancer cell line HT29 through N-acetylgalactosamine-transferase 3
Journal Name: Biological Chemistry
Volume: 399
Issue: 7
Pages: 649-659
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Hypoxia and serum deprivation induces glycan alterations in triple negative breast cancer cells
Journal Name: Biological Chemistry
Volume: 399
Issue: 7
Pages: 661-672
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DNA-encoded libraries – an efficient small molecule discovery technology for the biomedical sciences
Journal Name: Biological Chemistry
Volume: 399
Issue: 7
Pages: 691-710
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Protein crystallization in living cells
Journal Name: Biological Chemistry
Volume: 399
Issue: 7
Pages: 751-772
https://ift.tt/2JGENdx
Spectroscopic characterization of the Co-substituted C-terminal domain of rubredoxin-2
Journal Name: Biological Chemistry
Volume: 399
Issue: 7
Pages: 787-798
https://ift.tt/2LFvxDF
Twitch or swim: towards the understanding of prokaryotic motion based on the type IV pilus blueprint
Journal Name: Biological Chemistry
Volume: 399
Issue: 7
Pages: 799-808
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Standing variation and the capacity for change: are endocrine phenotypes more variable than other traits?
https://ift.tt/2LI9Tyx
A spatially explicit model shows how titin stiffness modulates muscle mechanics and energetics
https://ift.tt/2JMpFeA
Understanding the agility of running birds: Sensorimotor and mechanical factors in avian bipedal locomotion
https://ift.tt/2HIJE8H
The Influence of Visual, Vestibular and Hindlimb Proprioceptive Ablations on Landing Preparation in Cane Toads
https://ift.tt/2JMpBvm
CD4+CD45RA−FOXP3low Regulatory T Cells as Potential Biomarkers of Disease Activity in Systemic Lupus Erythematosus Brazilian Patients
Heren, we analyzed Treg cells as potential biomarkers of disease activity in systemic lupus erythematosus (SLE) patients. Peripheral blood mononuclear cells from 30 SLE patients (15 active: SLEDAI > 6/15 SLE remission: SLEDAI
https://ift.tt/2Jwhp37
Students’ Motivation for Sport Activity and Participation in University Sports: A Mixed-Methods Study
Background. Physical activity among students is essential for complimenting sedentary behavior and for individuals' future health. This study investigates reasons for sport engagement among students and addresses the utilization of university sports programs (USP) by employing a mixed-methods approach. Methods. The NuPhA-Study consists of a quantitative online survey (n=689) followed by qualitative interviews (n=20). In the survey, we assessed reasons for sport activity using a 24-item battery and USP utilization. Quantitative results were further explored using qualitative data to check for completeness of the predefined items (content validity) and to identify opportunities to improve participating in USP. Results. A factor analysis grouped the 24 items into five factors (life balance/fitness/body image/contact with others/fun). Our qualitative study explained these in more detail and revealed missing aspects. 47.6% of students participated in USP. Potential improvements for USP include program maintenance during the semester break and temporal harmonization with the classes. Discussion. The qualitative component identified additional reasons for sport activity that were not addressed by the item battery, which provides critical implications for developing item batteries for future research. Our results may help to generate a more target-group-oriented approach to increase physical activity among students, which will reduce sedentary behavior and future disease burden.
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Functional Impairments Associated with Patient Activation among Community-Dwelling Older Adults
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Bone marrow fat physiology in relation to skeletal metabolism and cardiometabolic disease risk in children with cerebral palsy
https://ift.tt/2sRXEZa
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Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
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heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
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