Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells

Type 2 immunity underpins diverse processes central to tissue homeostasis, allergic inflammation, and anti-helminth immunity. Halim et al. demonstrate that the local expansion of Th2 and Treg cells in response to the alarmin IL-33 is dependent on the expression of the costimulatory molecule OX40L by type 2 innate lymphoid cells (ILC2s), revealing a central role for the IL-33-ILC2-OX40L pathway in the orchestration of type 2 immunity.

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