Κυριακή 2 Ιουλίου 2017
Head and Neck Diseases
Brassica rapa hairy root extracts promote skin depigmentation by modulating melanin production and distribution
Summary Background Skin whitening products, used for ages by Asian people for cultural and esthetic purposes, are very popular nowadays in Western countries as well, where the need to inhibit skin spots after sun exposure has become not only a cosmetic but also a health-related issue. Thus, the development of effective and safe depigmenting agents derived from natural products gets continuous attention by cosmetic brands and consumers. Objectives The aim of this study was to determine the effects of two preparations, obtained from the hairy root cultures of the species *Brassica ... περισσότερα »
Brassica rapa hairy root extracts promote skin depigmentation by modulating melanin production and distribution
Summary Background Skin whitening products, used for ages by Asian people for cultural and esthetic purposes, are very popular nowadays in Western countries as well, where the need to inhibit skin spots after sun exposure has become not only a cosmetic but also a health-related issue. Thus, the development of effective and safe depigmenting agents derived from natural products gets continuous attention by cosmetic brands and consumers. Objectives The aim of this study was to determine the effects of two preparations, obtained from the hairy root cultures of the species *Brassica ... περισσότερα »
Measurement of Pharyngo-laryngeal Volume During Swallowing Using 320-Row Area Detector Computed Tomography
Abstract This study aimed to (1) evaluate changes in bolus and air volumes in the pharyngo-laryngeal cavity during swallowing and (2) determine how differences in these volumes during swallowing are influenced by bolus amount using 320-row area detector computed tomography (320-ADCT). Three-, 10-, and 20-ml honey-thick liquids (5% w/v) were presented to ten healthy subjects placed in a 45° reclining position. 3D images were created in 29 phases at an interval of 0.1 s for 3.15 s. Changes in bolus and air volumes in the pharyngo-laryngeal cavity were calculated. The two one-sided te... περισσότερα »
Subcutaneous mycoses in Peru: a systematic review and meta-analysis for the burden of disease
Abstract Background There is a worrying lack of epidemiological data on the geographical distribution and burden of subcutaneous mycoses in Peru, hindering the implementation of surveillance and control programs. Objectives This study aimed to estimate the disease burden of subcutaneous mycoses in Peru and identify which fungal species were commonly associated with these mycoses. Methods We performed a meta-analysis after a systematic review of the published literature in PubMed, LILACS, and SciELO to estimate the burden of subcutaneous mycoses in 25 regions in Peru. The diseas... περισσότερα »
Subcutaneous mycoses in Peru: a systematic review and meta-analysis for the burden of disease
Abstract Background There is a worrying lack of epidemiological data on the geographical distribution and burden of subcutaneous mycoses in Peru, hindering the implementation of surveillance and control programs. Objectives This study aimed to estimate the disease burden of subcutaneous mycoses in Peru and identify which fungal species were commonly associated with these mycoses. Methods We performed a meta-analysis after a systematic review of the published literature in PubMed, LILACS, and SciELO to estimate the burden of subcutaneous mycoses in 25 regions in Peru. The diseas... περισσότερα »
Burden and health-related quality of life of eating disorders, including Avoidant/Restrictive Food Intake Disorder (ARFID), in the Australian population
Abstract Background Little is known about the epidemiology and health related quality of life (HRQoL) of the new DSM-5 diagnoses, Binge Eating Disorder (BED) and Avoidant/Restrictive Food Intake Disorder (ARFID) in the Australian population. We aimed to investigate the prevalance and burden of these disorders. Methods We conducted two sequential population-based surveys including individuals aged over 15 years who were interviewed in 2014 (*n* = 2732) and 2015 (*n* =3005). Demographic information and diagnostic features of DSM-5 eating disorders were asked including the occurrenc... περισσότερα »
CIK as therapeutic agents against tumors
Publication date: Available online 2 July 2017 *Source:*Journal of Autoimmunity Author(s): M. Introna Cytokine Induced Killer (CIK) cells are ex vivo expanded and activated T lymphocytes obtained by sequential incubation of Peripheral Blood Mononuclear cells (PBMNC) with Interferon γ (IFNG), anti CD3 monoclonal antibody OKT3 and IL2.These cells, while retaining few characteristics of the Effector memory T cells subpopulation, acquired during culture CD56 expression, as well as non specific, Natural Killer like, anti tumoral cytotoxicity.CIK cells from human are equivalent to expande... περισσότερα »
A Case of Atopic Myelitis with Cervical Cavernous Angioma
Atopic myelitis, a type of myelitis which appears in patients with elevated serum levels of immunoglobulin E (IgE), occurs more commonly in the cervical spinal cord, but this mechanism has not yet been elucidated. Herein, we experienced a case of atopic myelitis developed during the growth of cervical cavernous angioma caused by bleeding. A 37-year-old woman suffered from hand swelling caused by a house cat licking. At the same time when cavernous angioma had grown, she experienced a numbness in her four extremities, and multifocal peritumoral hyperintense spinal cord signals were... περισσότερα »
A Case of Atopic Myelitis with Cervical Cavernous Angioma
Atopic myelitis, a type of myelitis which appears in patients with elevated serum levels of immunoglobulin E (IgE), occurs more commonly in the cervical spinal cord, but this mechanism has not yet been elucidated. Herein, we experienced a case of atopic myelitis developed during the growth of cervical cavernous angioma caused by bleeding. A 37-year-old woman suffered from hand swelling caused by a house cat licking. At the same time when cavernous angioma had grown, she experienced a numbness in her four extremities, and multifocal peritumoral hyperintense spinal cord signals were... περισσότερα »
A Case of Atopic Myelitis with Cervical Cavernous Angioma
Atopic myelitis, a type of myelitis which appears in patients with elevated serum levels of immunoglobulin E (IgE), occurs more commonly in the cervical spinal cord, but this mechanism has not yet been elucidated. Herein, we experienced a case of atopic myelitis developed during the growth of cervical cavernous angioma caused by bleeding. A 37-year-old woman suffered from hand swelling caused by a house cat licking. At the same time when cavernous angioma had grown, she experienced a numbness in her four extremities, and multifocal peritumoral hyperintense spinal cord signals were... περισσότερα »
Assessment of complete unilateral cleft lip and palate treatment outcome using EUROCRAN index and associated factors
[image: S01655876.gif] Publication date: September 2017 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 100 Author(s): Anas Imran Arshad, Mohammad Khursheed Alam, Mohd Fadhli Khamis ObjectivesAssessment of treatment outcome is the only non-invasive approach to identify the effects of cleft lip and palate repair and modify management accordingly. Here the aim is to assess the outcome of complete unilateral cleft lip and palate (CUCLP) patients using EUROCRAN index and to check whether there are any factors associated with the treatment outcome.Materials and met... περισσότερα »
Assessment of complete unilateral cleft lip and palate treatment outcome using EUROCRAN index and associated factors
[image: S01655876.gif] Publication date: September 2017 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 100 Author(s): Anas Imran Arshad, Mohammad Khursheed Alam, Mohd Fadhli Khamis ObjectivesAssessment of treatment outcome is the only non-invasive approach to identify the effects of cleft lip and palate repair and modify management accordingly. Here the aim is to assess the outcome of complete unilateral cleft lip and palate (CUCLP) patients using EUROCRAN index and to check whether there are any factors associated with the treatment outcome.Materials and met... περισσότερα »
Can Residents Be Trained and Safety Maintained?
Publication date: Available online 1 July 2017 *Source:*Journal of Surgical Education Author(s): Marina Gorelik, Steven Godelman, Adel Elkbuli, Lauren Allen, Dessy Boneva, Mark McKenney IntroductionTeaching hospitals and faculty need to balance the educational mission for training residents with patient safety. There are no data studying the change in trauma patient outcomes before and after implementation of a surgical residency. The objective of this study was to compare trauma center outcomes before and after the advent of a surgical training program. We predicted that patient-ce... περισσότερα »
Multiple Non-Syndromic Bilaterally Erupted Para Premolars in the Mandibular Arch: A Case Report
Authors: Amit Mehra [1], Amit Rekhi [2] Affiliations: [1] Professor, Department of Orthodontics and Dentofacial Orthopedics, Himachal Institute of Dental Sciences, Himachal Pradesh, India [2] Senior Lecturer, Department of Public Health Dentistry, Uttaranchal Dental and Medical Research Institute, Uttarakhand, India Conflict of Interest: None declared This article has been peer reviewed. Article Submitted on: 11th […] http://ift.tt/2tB4vrk
NCI UNC Project ESCC
*Condition*: Esophageal Squamous Cell Carcinoma *Intervention*: *Sponsor*: National Cancer Institute (NCI) *Not yet recruiting* - verified June 26, 2017 http://ift.tt/2tFbXSY
Eltrombopag for People With Fanconi Anemia
*Condition*: Fanconi's Anemia *Intervention*: Drug: Eltrombopag *Sponsor*: National Heart, Lung, and Blood Institute (NHLBI) *Not yet recruiting* - verified June 28, 2017 http://ift.tt/2ueJQHd
NCI UNC Project ESCC
*Condition*: Esophageal Squamous Cell Carcinoma *Intervention*: *Sponsor*: National Cancer Institute (NCI) *Not yet recruiting* - verified June 26, 2017 http://ift.tt/2tFbXSY
NCI UNC Project ESCC
*Condition*: Esophageal Squamous Cell Carcinoma *Intervention*: *Sponsor*: National Cancer Institute (NCI) *Not yet recruiting* - verified June 26, 2017 http://ift.tt/2tFbXSY
Eltrombopag for People With Fanconi Anemia
*Condition*: Fanconi's Anemia *Intervention*: Drug: Eltrombopag *Sponsor*: National Heart, Lung, and Blood Institute (NHLBI) *Not yet recruiting* - verified June 28, 2017 http://ift.tt/2ueJQHd
Eltrombopag for People With Fanconi Anemia
*Condition*: Fanconi's Anemia *Intervention*: Drug: Eltrombopag *Sponsor*: National Heart, Lung, and Blood Institute (NHLBI) *Not yet recruiting* - verified June 28, 2017 http://ift.tt/2ueJQHd
Contributors
J. REGAN THOMAS, MD, FACS http://ift.tt/2t656QX
Contributors
J. REGAN THOMAS, MD, FACS http://ift.tt/2t656QX
Contents
James B. Lucas http://ift.tt/2sBrYob
Contents
James B. Lucas http://ift.tt/2sBrYob
Skin and Composite Grafting Techniques in Facial Reconstruction for Skin Cancer
Skin and composite grafting provide effective resurfacing and reconstruction for cutaneous defects after excision of the malignancy. The goal is to restore a natural appearance and function while preventing distortion of the eyelid, nose, or lips. With careful planning and attention to aesthetic subunits, the surgeon can camouflage incisions and avoid blunting aesthetically sensitive sulci. The surgical plan is also informed by the pathology, as basal or squamous cell carcinomas removed by Mohs micrographic excision have different prognostic and logistical considerations from mela...περισσότερα »
Skin and Composite Grafting Techniques in Facial Reconstruction for Skin Cancer
Skin and composite grafting provide effective resurfacing and reconstruction for cutaneous defects after excision of the malignancy. The goal is to restore a natural appearance and function while preventing distortion of the eyelid, nose, or lips. With careful planning and attention to aesthetic subunits, the surgeon can camouflage incisions and avoid blunting aesthetically sensitive sulci. The surgical plan is also informed by the pathology, as basal or squamous cell carcinomas removed by Mohs micrographic excision have different prognostic and logistical considerations from mela...περισσότερα »
Defect of the Eyelids
Eyelid defects disrupt the complex natural form and function of the eyelids and present a surgical challenge. Detailed knowledge of eyelid anatomy is essential in evaluating a defect and composing a reconstructive plan. Numerous reconstructive techniques have been described, including primary closure, grafting, and a variety of local flaps. This article describes an updated reconstructive ladder for eyelid defects that can be used in various permutations to solve most eyelid defects. http://ift.tt/2sBuCuc
Defect of the Eyelids
Eyelid defects disrupt the complex natural form and function of the eyelids and present a surgical challenge. Detailed knowledge of eyelid anatomy is essential in evaluating a defect and composing a reconstructive plan. Numerous reconstructive techniques have been described, including primary closure, grafting, and a variety of local flaps. This article describes an updated reconstructive ladder for eyelid defects that can be used in various permutations to solve most eyelid defects. http://ift.tt/2sBuCuc
Flap Basics III
Paramedian forehead and melolabial flaps are the most common examples of interpolated flaps used by facial plastic surgeons and are excellent options for reconstruction of the midface after Mohs surgery. They provide superior tissue match in terms of thickness, texture, and color, while leaving minimal defects at the tissue donor sites. The main advantage of interpolated flaps is the robust blood supply, which can be either axial of randomly based, and the maintenance of the integrity of facial landmarks. The main disadvantage is the frequent need for a multistage procedure, which...περισσότερα »
Flap Basics III
Paramedian forehead and melolabial flaps are the most common examples of interpolated flaps used by facial plastic surgeons and are excellent options for reconstruction of the midface after Mohs surgery. They provide superior tissue match in terms of thickness, texture, and color, while leaving minimal defects at the tissue donor sites. The main advantage of interpolated flaps is the robust blood supply, which can be either axial of randomly based, and the maintenance of the integrity of facial landmarks. The main disadvantage is the frequent need for a multistage procedure, which...περισσότερα »
Forthcoming Issues
Trauma in Facial Plastic Surgery http://ift.tt/2sBt1Vb
Forthcoming Issues
Trauma in Facial Plastic Surgery http://ift.tt/2sBt1Vb
Flap Basics II
A mastery of advancement flap design, selection, and execution greatly aids the surgeon in solving reconstructive dilemmas. Advancement flaps involve carefully planned incisions to most efficiently close a primary defect in a linear vector. Advancement flaps are subcategorized as unipedicle, bipedicle, V-to-Y, and Y-to-V flaps, each with their own advantages and disadvantages. When selecting and designing an advancement flap, the surgeon must account for primary and secondary movement to prevent distortion of important facial structural units and boundaries. http://ift.tt/2t6g2yl
Flap Basics II
A mastery of advancement flap design, selection, and execution greatly aids the surgeon in solving reconstructive dilemmas. Advancement flaps involve carefully planned incisions to most efficiently close a primary defect in a linear vector. Advancement flaps are subcategorized as unipedicle, bipedicle, V-to-Y, and Y-to-V flaps, each with their own advantages and disadvantages. When selecting and designing an advancement flap, the surgeon must account for primary and secondary movement to prevent distortion of important facial structural units and boundaries. http://ift.tt/2t6g2yl
Index
Note: Page numbers of article titles are in boldface type. http://ift.tt/2sBw5Au
Index
Note: Page numbers of article titles are in boldface type. http://ift.tt/2sBw5Au
Repair of Auricular Defects
Repairing defects of the auricle requires an appreciation of the underlying 3-dimensional framework, the flexible properties of the cartilages, and the healing contractile tendencies of the surrounding soft tissue. In the analysis of auricular defects and planning of their reconstruction, it is helpful to divide the auricle into subunits for which different techniques may offer better functional and aesthetic outcomes. This article reviews many of the reconstructive options for defects of the various auricular subunits. http://ift.tt/2t6f3OD
Repair of Auricular Defects
Repairing defects of the auricle requires an appreciation of the underlying 3-dimensional framework, the flexible properties of the cartilages, and the healing contractile tendencies of the surrounding soft tissue. In the analysis of auricular defects and planning of their reconstruction, it is helpful to divide the auricle into subunits for which different techniques may offer better functional and aesthetic outcomes. This article reviews many of the reconstructive options for defects of the various auricular subunits. http://ift.tt/2t6f3OD
Facial Reconstruction Post-Mohs Surgery
FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA http://ift.tt/2sBkQZ0
Facial Reconstruction Post-Mohs Surgery
FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA http://ift.tt/2sBkQZ0
Reconstruction of Mohs Defects of the Lips and Chin
Reconstruction of defects of the lips after Mohs micrographic surgery should encompass functional and aesthetic concerns. The lower lip and chin compose two-thirds of the lower portion of the face. The focus of this article is local tissue transfer for primarily cutaneous defects after Mohs surgery. Various flaps exist for repair. For small defects, elliptical excision with primary closure is a viable option. During reconstruction of the lip, all of the involved layers need to be addressed, including mucosa, muscle, and the vermillion or cutaneous lip. It is especially important to... περισσότερα »
Reconstruction of Mohs Defects of the Lips and Chin
Reconstruction of defects of the lips after Mohs micrographic surgery should encompass functional and aesthetic concerns. The lower lip and chin compose two-thirds of the lower portion of the face. The focus of this article is local tissue transfer for primarily cutaneous defects after Mohs surgery. Various flaps exist for repair. For small defects, elliptical excision with primary closure is a viable option. During reconstruction of the lip, all of the involved layers need to be addressed, including mucosa, muscle, and the vermillion or cutaneous lip. It is especially important to... περισσότερα »
Reconstruction of Cheek Defects Secondary to Mohs Microsurgery or Wide Local Excision
Successful reconstruction of the cheek following excision for cutaneous malignancy requires careful consideration of defect location, size, and depth in relation to the anatomic properties of the affected cheek unit. Various reconstructive options are available to the surgeon, ranging from simple excisions to complex cervicofacial advancements to meet the needs for functional and aesthetically pleasing reconstructive outcomes. The surgeon must prevent distortion of mobile structures, such as the eyelid, nose, and lips; respect aesthetic subunits; and avoid blunting natural creases...περισσότερα »
Reconstruction of Cheek Defects Secondary to Mohs Microsurgery or Wide Local Excision
Successful reconstruction of the cheek following excision for cutaneous malignancy requires careful consideration of defect location, size, and depth in relation to the anatomic properties of the affected cheek unit. Various reconstructive options are available to the surgeon, ranging from simple excisions to complex cervicofacial advancements to meet the needs for functional and aesthetically pleasing reconstructive outcomes. The surgeon must prevent distortion of mobile structures, such as the eyelid, nose, and lips; respect aesthetic subunits; and avoid blunting natural creases...περισσότερα »
Copyright
ELSEVIER http://ift.tt/2t6g2hP
Copyright
ELSEVIER http://ift.tt/2t6g2hP
In Pursuit of Perfection: The Art of Facial Restoration
One of the common traits that inspire young surgeons to pursue a calling in the reconstructive arts is a passion for restoration. The ability to restore balance and harmony to the human form, to re-create function and beauty in an area where it has been lost or compromised, is one of the requisite fundamental skills that all plastic surgeons seek to acquire and perfect throughout their career. It is the sine qua non in the art of aesthetic and reconstructive surgery. http://ift.tt/2sByE5x
In Pursuit of Perfection: The Art of Facial Restoration
One of the common traits that inspire young surgeons to pursue a calling in the reconstructive arts is a passion for restoration. The ability to restore balance and harmony to the human form, to re-create function and beauty in an area where it has been lost or compromised, is one of the requisite fundamental skills that all plastic surgeons seek to acquire and perfect throughout their career. It is the sine qua non in the art of aesthetic and reconstructive surgery. http://ift.tt/2sByE5x
Contributors
J. REGAN THOMAS, MD, FACS http://ift.tt/2t656QX
Contents
James B. Lucas http://ift.tt/2sBrYob
Skin and Composite Grafting Techniques in Facial Reconstruction for Skin Cancer
Skin and composite grafting provide effective resurfacing and reconstruction for cutaneous defects after excision of the malignancy. The goal is to restore a natural appearance and function while preventing distortion of the eyelid, nose, or lips. With careful planning and attention to aesthetic subunits, the surgeon can camouflage incisions and avoid blunting aesthetically sensitive sulci. The surgical plan is also informed by the pathology, as basal or squamous cell carcinomas removed by Mohs micrographic excision have different prognostic and logistical considerations from mela...περισσότερα »
Defect of the Eyelids
Eyelid defects disrupt the complex natural form and function of the eyelids and present a surgical challenge. Detailed knowledge of eyelid anatomy is essential in evaluating a defect and composing a reconstructive plan. Numerous reconstructive techniques have been described, including primary closure, grafting, and a variety of local flaps. This article describes an updated reconstructive ladder for eyelid defects that can be used in various permutations to solve most eyelid defects. http://ift.tt/2sBuCuc
Flap Basics III
Paramedian forehead and melolabial flaps are the most common examples of interpolated flaps used by facial plastic surgeons and are excellent options for reconstruction of the midface after Mohs surgery. They provide superior tissue match in terms of thickness, texture, and color, while leaving minimal defects at the tissue donor sites. The main advantage of interpolated flaps is the robust blood supply, which can be either axial of randomly based, and the maintenance of the integrity of facial landmarks. The main disadvantage is the frequent need for a multistage procedure, which...περισσότερα »
Forthcoming Issues
Trauma in Facial Plastic Surgery http://ift.tt/2sBt1Vb
Flap Basics II
A mastery of advancement flap design, selection, and execution greatly aids the surgeon in solving reconstructive dilemmas. Advancement flaps involve carefully planned incisions to most efficiently close a primary defect in a linear vector. Advancement flaps are subcategorized as unipedicle, bipedicle, V-to-Y, and Y-to-V flaps, each with their own advantages and disadvantages. When selecting and designing an advancement flap, the surgeon must account for primary and secondary movement to prevent distortion of important facial structural units and boundaries. http://ift.tt/2t6g2yl
Index
Note: Page numbers of article titles are in boldface type. http://ift.tt/2sBw5Au
Repair of Auricular Defects
Repairing defects of the auricle requires an appreciation of the underlying 3-dimensional framework, the flexible properties of the cartilages, and the healing contractile tendencies of the surrounding soft tissue. In the analysis of auricular defects and planning of their reconstruction, it is helpful to divide the auricle into subunits for which different techniques may offer better functional and aesthetic outcomes. This article reviews many of the reconstructive options for defects of the various auricular subunits. http://ift.tt/2t6f3OD
Facial Reconstruction Post-Mohs Surgery
FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA http://ift.tt/2sBkQZ0
Reconstruction of Mohs Defects of the Lips and Chin
Reconstruction of defects of the lips after Mohs micrographic surgery should encompass functional and aesthetic concerns. The lower lip and chin compose two-thirds of the lower portion of the face. The focus of this article is local tissue transfer for primarily cutaneous defects after Mohs surgery. Various flaps exist for repair. For small defects, elliptical excision with primary closure is a viable option. During reconstruction of the lip, all of the involved layers need to be addressed, including mucosa, muscle, and the vermillion or cutaneous lip. It is especially important to... περισσότερα »
Reconstruction of Cheek Defects Secondary to Mohs Microsurgery or Wide Local Excision
Successful reconstruction of the cheek following excision for cutaneous malignancy requires careful consideration of defect location, size, and depth in relation to the anatomic properties of the affected cheek unit. Various reconstructive options are available to the surgeon, ranging from simple excisions to complex cervicofacial advancements to meet the needs for functional and aesthetically pleasing reconstructive outcomes. The surgeon must prevent distortion of mobile structures, such as the eyelid, nose, and lips; respect aesthetic subunits; and avoid blunting natural creases...περισσότερα »
Copyright
ELSEVIER http://ift.tt/2t6g2hP
In Pursuit of Perfection: The Art of Facial Restoration
One of the common traits that inspire young surgeons to pursue a calling in the reconstructive arts is a passion for restoration. The ability to restore balance and harmony to the human form, to re-create function and beauty in an area where it has been lost or compromised, is one of the requisite fundamental skills that all plastic surgeons seek to acquire and perfect throughout their career. It is the sine qua non in the art of aesthetic and reconstructive surgery. http://ift.tt/2sByE5x
Personality predicts the vibrancy of colour imagery: The case of synaesthesia
[image: S00109452.gif] Publication date: Available online 1 July 2017 *Source:*Cortex Author(s): Shyla R. Hossain, Julia Simner, Alberta Ipser In this study we show that personality traits predict the physical qualities of mentally generated colours, using the case of synaesthesia. Developmental grapheme-colour synaesthetes have the automatic lifelong association of colours paired to letters or digits. Although these colours are internal mental constructs, they can be measured along physical dimensions such as saturation and luminance. The personality of synaesthetes can also be qua...περισσότερα »
Emergency Department Flow Measures for Adult and Pediatric Patients in British Columbia and Ontario: A Retrospective, Repeated Cross-Sectional Study
[image: S07364679.gif] Publication date: Available online 1 July 2017 *Source:*The Journal of Emergency Medicine Author(s): Gregory Georgio, Astrid Guttmann, Quynh H. Doan BackgroundEvidence suggests emergency department (ED) overcrowding is associated with poor health outcomes. Children comprise 20–25% of general ED visits, yet few studies have examined the differential impact of ED overcrowding on pediatric and adult populations.ObjectiveThe primary objective of this study was to compare flow measures, such as wait time to see a physician, length of stay (LOS), and rate of patients... περισσότερα »
Autophagy inhibition enabled efficient photothermal therapy at a mild temperature
[image: S01429612.gif] Publication date: October 2017 *Source:*Biomaterials, Volume 141 Author(s): Zhengjie Zhou, Yang Yan, Kewen Hu, Yuan Zou, Yiwen Li, Rui Ma, Qiang Zhang, Yiyun Cheng The heterogeneously-distributed hyperthermia in nanomaterial-mediated photothermal therapy commonly results in incomplete tumor eradication and serious damage of health tissue. Here, we found autophagy was activated in cancer cells underwent photothermal therapy and the inhibition of autophagy significantly enhanced the efficacy of photothermal killing of cancer cells. A formulation of chloroquine-l... περισσότερα »
Editorial board
[image: alertIcon.gif] Publication date: September 2017 *Source:*Biomaterials, Volume 140 http://ift.tt/2suTKr8
Macrophages with cellular backpacks for targeted drug delivery to the brain
[image: 1-s2.0-S0142961217X00215-cov150h.gif] Publication date: September 2017 *Source:*Biomaterials, Volume 140 Author(s): Natalia L. Klyachko, Roberta Polak, Matthew J. Haney, Yuling Zhao, Reginaldo J. Gomes Neto, Michael C. Hill, Alexander V. Kabanov, Robert E. Cohen, Michael F. Rubner, Elena V. Batrakova Most potent therapeutics are unable to cross the blood-brain barrier following systemic administration, which necessitates the development of unconventional, clinically applicable drug delivery systems. With the given challenges, biologically active vehicles are crucial to accomp... περισσότερα »
Effects of allergen sensitization on response to therapy in children with eosinophilic esophagitis
[image: S10811206.gif] Publication date: Available online 1 July 2017 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Robert D. Pesek, Mallikarjuna Rettiganti, Erin O'Brien, Sarah Beckwith, Caroline Daniel, Chunqiao Luo, Amy M. Scurlock, Peggy Chandler, Rebecca A. Levy, Tamara T. Perry, Joshua L. Kennedy, Sheva Chervinskiy, Maryelle Vonlanthen, Helen Casteel, Stephen C. Fiedorek, Troy Gibbons, Stacie M. Jones BackgroundIn children with eosinophilic esophagitis (EoE) foods are the most common disease triggers, but environmental allergens are also suspected culprits.Objecti... περισσότερα »
Effects of allergen sensitization on response to therapy in children with eosinophilic esophagitis
[image: S10811206.gif] Publication date: Available online 1 July 2017 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Robert D. Pesek, Mallikarjuna Rettiganti, Erin O'Brien, Sarah Beckwith, Caroline Daniel, Chunqiao Luo, Amy M. Scurlock, Peggy Chandler, Rebecca A. Levy, Tamara T. Perry, Joshua L. Kennedy, Sheva Chervinskiy, Maryelle Vonlanthen, Helen Casteel, Stephen C. Fiedorek, Troy Gibbons, Stacie M. Jones BackgroundIn children with eosinophilic esophagitis (EoE) foods are the most common disease triggers, but environmental allergens are also suspected culprits.Objecti... περισσότερα »
Epinephrine use for anaphylaxis: Too seldom, too late
[image: alertIcon.gif] Publication date: Available online 1 July 2017 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Rishma Chooniedass, Beverley Temple, Allan Becker http://ift.tt/2tEDCUi
Epinephrine use for anaphylaxis: Too seldom, too late
[image: alertIcon.gif] Publication date: Available online 1 July 2017 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Rishma Chooniedass, Beverley Temple, Allan Becker http://ift.tt/2tEDCUi
Efficacy of oral immunotherapy with a rice-based edible vaccine containing hypoallergenic Japanese cedar pollen allergens for treatment of established allergic conjunctivitis in mice
Publication date: Available online 1 July 2017 *Source:*Allergology International Author(s): Ken Fukuda, Waka Ishida, Yosuke Harada, Yuhya Wakasa, Hidenori Takagi, Fumio Takaiwa, Atsuki Fukushima BackgroundWe have previously shown that prophylactic oral administration of transgenic rice seeds expressing hypoallergenic modified antigens suppressed the development of allergic conjunctivitis induced by Japanese cedar pollen. We have now investigated the efficacy of oral immunotherapy with such transgenic rice for established allergic conjunctivitis in mice.MethodsBALB/c mice were sensi... περισσότερα »
Efficacy of oral immunotherapy with a rice-based edible vaccine containing hypoallergenic Japanese cedar pollen allergens for treatment of established allergic conjunctivitis in mice
Publication date: Available online 1 July 2017 *Source:*Allergology International Author(s): Ken Fukuda, Waka Ishida, Yosuke Harada, Yuhya Wakasa, Hidenori Takagi, Fumio Takaiwa, Atsuki Fukushima BackgroundWe have previously shown that prophylactic oral administration of transgenic rice seeds expressing hypoallergenic modified antigens suppressed the development of allergic conjunctivitis induced by Japanese cedar pollen. We have now investigated the efficacy of oral immunotherapy with such transgenic rice for established allergic conjunctivitis in mice.MethodsBALB/c mice were sensi... περισσότερα »
Prodrugs in medicinal chemistry and enzyme prodrug therapies
Publication date: Available online 1 July 2017 *Source:*Advanced Drug Delivery Reviews Author(s): Raoul Walther, Jarkko Rautio, Alexander N. Zelikin Prodrugs are cunning derivatives of therapeutic agents designed to improve the pharmacokinetics profile of the drug. Within a prodrug, pharmacological activity of the drug is masked and is recovered within the human body upon bioconversion of the prodrug, a process that is typically mediated by enzymes. This concept is highly successful and a significant fraction of marketed therapeutic formulations is based on prodrugs. An advanced subs... περισσότερα »
Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein expression predicts disease severity in chronic hepatitis C patients
Publication date: Available online 1 July 2017 *Source:*The Kaohsiung Journal of Medical Sciences Author(s): Ching-I Huang, Chung-Feng Huang, Ming-Lun Yeh, Yi-Hung Lin, Po-Cheng Liang, Meng-Hsuan Hsieh, Chia-Yen Dai, Ming-Yen Hsieh, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Ming-Lung Yu, Wan-Long Chuang Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) has recently been developed as a promising liver fibrosis glyco biomarker. We assessed its efficacy in evaluating liver disease severity in chronic hepatitis C (CHC) in Taiwan. The association between WFA+-M2... περισσότερα »
Acceleration of skin wound healing by low-dose indirect ionizing radiation in male rats
Publication date: Available online 1 July 2017 *Source:*The Kaohsiung Journal of Medical Sciences Author(s): Nasrollah Jabbari, Gholam Hossein Farjah, Behnam Ghadimi, Hajar Zanjani, Behnam Heshmatian A recent hypothesis has revealed that low-dose irradiation (LDI) with ionizing radiation might have a promoting effect on fracture healing. The aim of this study was to investigate the influence of direct (electron beam) and indirect (gamma-ray) low-dose ionizing irradiations on the wound healing process in male rats. In 72 male rats, a full-thickness wound was incised. The animals were... περισσότερα »
High frequencies of a favorable IL-28B rs8099917 polymorphism and the clinical implications in patients with HCV in one multiracial area of Taiwan
Publication date: Available online 1 July 2017 *Source:*The Kaohsiung Journal of Medical Sciences Author(s): Chun-Han Cheng, Ching-Chung Lin, Huan-Lin Chen, I.-Tsung Lin, Chia-Hsien Wu, Yuan-Kai Lee, Ming-Wun Wong, Ming-Jong Bair There is a strong association between hepatitis C virus (HCV) treatment efficacy and the interleukin (IL)-28B gene. However, the IL-28B variant's distribution and potential role in the therapeutic response are not well established in Taitung, a racially diverse county in Taiwan. Here, we investigated the distribution pattern of IL-28B rs8099917 and its influ...περισσότερα »
Evaluation of Sedation-Related Medication Errors in Contact Isolation Patients in the ICU.
*Evaluation of Sedation-Related Medication Errors in Contact Isolation Patients in the ICU.* J Hosp Infect. 2017 Jun 27;: Authors: Searcy R, Johnson D, Jankowski C, Ferreira J Abstract BACKGROUND: Patients in the intensive care unit (ICU), may be placed in contact isolation (CI) for meticillin-resistant Staphylococcus aureus (MRSA) colonization to prevent transmission. Prior studies suggest that isolated patients may receive substandard care compared to patients not on isolation. An optimal level of sedation is required to facilitate mechanical ventilation (MV) and to minimize ad... περισσότερα »
Synthesis and biological evaluation of novel steroidal 5α,8α-epidioxyandrost-6-ene-3β-ol-17-(O-phenylacetamide)oxime derivatives as potential anticancer agents.
*Synthesis and biological evaluation of novel steroidal 5α,8α-epidioxyandrost-6-ene-3β-ol-17-(O-phenylacetamide)oxime derivatives as potential anticancer agents.* Bioorg Med Chem Lett. 2017 Jun 21;: Authors: Bu M, Cao T, Li H, Guo M, Yang BB, Zeng C, Zhou Y, Zhang N, Hu L Abstract Inspired by the significant anti-cancer activity of our previously screened natural ergosterol peroxide (EP, 1), we synthesized and characterized a series of novel 5α,8α-epidioxyandrost-3β-ol-17-(O-phenylacetamide)oxime derivatives (9a-o). The anti-proliferative activity of the synthesized compounds aga... περισσότερα »
Staged definitive repair after carotid blowout: a case report.
*Staged definitive repair after carotid blowout: a case report.* Ann Vasc Surg. 2017 Jun 27;: Authors: Loja MN, Abbot C, Isaacs R, Brawley J, Humphries M Abstract Carotid blowout syndrome is a highly morbid complication of head and neck cancer. We present the case of a 51-year old woman with common carotid artery blowout, initially temporized with an endovascular stent graft and ultimately reconstructed using autologous superficial femoral artery. The patient recovered without sequelae and continues to be asymptomatic at one year. We present the modern hybrid management of this co... περισσότερα »
Joint Attention and Oromotor Abilities in Young Children With and Without Autism Spectrum Disorder
[image: S00219924.gif] Publication date: Available online 1 July 2017 *Source:*Journal of Communication Disorders Author(s): Jennifer C. Dalton, Elizabeth R. Crais, Shelley L. Velleman PurposeThis study examined the relationship between joint attention ability and oromotor imitation skill in three groups of young children with and without Autism Spectrum Disorder using both nonverbal oral and verbal motor imitation tasks. Research questions addressed a) differences among joint attention and oromotor imitation abilities; b) the relationship between independently measured joint attenti... περισσότερα »
Inferior Limb Salvage by Combined Free-tissue Transfer and the Crane Principle Revisited
[image: image]Summary: Aggressive treatment of ischemia of the lower extremities has decreased the number of amputations in both diabetic and nondiabetic patients; combined vascular reconstruction and microvascular free-flap transfer has been used to improve distal perfusion and cover large tissue defects caused by the critical limb ischemia during the past 30 years. We present our experience with a 71-year-old diabetic patient who underwent revascularization with a vascular bypass and a simultaneous microvascular flap reconstruction for limb salvage after domestic trauma. An extens... περισσότερα »
Geospatial analysis of dissolved nutrients dataset in the surface water of Karayar reservoir, Southern India
Publication date: August 2017 *Source:*Data in Brief, Volume 13 Author(s): N.S. Magesh, N. Chandrasekar, S. Krishnakumar Spatial dataset representing the nutrient distribution in Karayar reservoir during pre and post-monsoon season is presented. Random sampling method was used for data collection and the sample location were fixed using a handheld global positioning system (Garmin GPSMAP-76). The nutrients were estimated using the standard techniques as described in the American Public Health Association (APHA) manual. Physical parameters were estimated using a Hanna portable multi ... περισσότερα »
Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature
Sertoli-Leydig Cell Tumors (SLCTs) make up http://ift.tt/2tzC4tY
Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature
Sertoli-Leydig Cell Tumors (SLCTs) make up http://ift.tt/2tzC4tY
Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature
Sertoli-Leydig Cell Tumors (SLCTs) make up http://ift.tt/2tzC4tY
Shaping functional gut microbiota using dietary bioactives to reduce colon cancer risk
[image: S1044579X.gif] Publication date: Available online 1 July 2017 *Source:*Seminars in Cancer Biology Author(s): Derek V. Seidel, M. Andrea Azcárate-Peril, Robert S. Chapkin, Nancy D. Turner Colon cancer is a multifactorial disease associated with a variety of lifestyle factors. Alterations in the gut microbiota and the intestinal metabolome are noted during colon carcinogenesis, implicating them as critical contributors or results of the disease process. Diet is a known determinant of health, and as a modifier of the gut microbiota and its metabolism, a critical element in main... περισσότερα »
Nutrigenomics in cancer: revisiting the effects of natural compounds
[image: S1044579X.gif] Publication date: Available online 1 July 2017 *Source:*Seminars in Cancer Biology Author(s): Cornelia Braicu, Nikolay Mehterov, Boyan Vladimirov, Victoria Sarafian, Seyed Nabavi, Atanas G. Atanasov, Ioana Berindan-Neagoe Nutrigenomics effects have an important role in the manipulation of dietary components for human benefit, particularly in cancer prevention or treatment. The impact of dietary components, including phytochemicals, is largely studied by nutrigenomics, looking at the gene expression and molecular mechanisms interacting with bioactive compounds a... περισσότερα »
Transition from melting to carbonization of naphthalene, anthracene, pyrene and coronene at high pressure
Publication date: Available online 1 July 2017 *Source:*Physics of the Earth and Planetary Interiors Author(s): Artem D. Chanyshev, Konstantin D. Litasov, Anton F. Shatskiy, Igor S. Sharygin, Yuji Higo, Eiji Ohtani We have examined the decomposition of naphthalene, anthracene, pyrene and coronene at high pressures and temperatures. Experiments were performed using in situ X-ray diffraction in multianvil apparatus at the SPring-8 synchrotron radiation facility. In the pressure range of 1.5–3.7 GPa decomposition of studied polycyclic aromatic hydrocarbons (PAHs) was detected at 773–97...περισσότερα »
Therapeutic application of human leukocyte antigen-G1 improves atopic dermatitis-like skin lesions in mice
Publication date: September 2017 *Source:*International Immunopharmacology, Volume 50 Author(s): Naoyoshi Maeda, Chisato Yamada, Ami Takahashi, Kimiko Kuroki, Katsumi Maenaka Human leukocyte antigen (HLA)-G is an immune checkpoint molecule that plays critical roles in immune response and in triggering inhibitory signaling to immune cells such as T cells, natural killer cells, and antigen-presenting cells. Thus, the application of HLA-G can be considered for treating immune response-related inflammatory disorders. We have previously reported that treatment with HLA-G1 and HLA-G2 amel... περισσότερα »
Investigation of the biodistribution, breakdown and excretion of delta inulin adjuvant
[image: S0264410X.gif] Publication date: Available online 1 July 2017 *Source:*Vaccine Author(s): Lixin Wang, Thomas Barclay, Yunmei Song, Paul Joyce, Isaac G. Sakala, Nikolai Petrovsky, Sanjay Garg Insoluble, nanostructured delta inulin particles enhance the immunogenicity of co-administered protein antigens and consequently are used as a vaccine adjuvant (Advax™). To better understand their immunomodulatory properties, the in vitro hydrolysis and in vivo distribution of delta inulin particles were investigated. Delta inulin particle hydrolysis under bio-relevant acidic conditions ...περισσότερα »
New perspectives for hexavalent vaccines
[image: S0264410X.gif] Publication date: Available online 1 July 2017 *Source:*Vaccine Author(s): Pablo Obando-Pacheco, Irene Rivero-Calle, José Gómez-Rial, Carmen Rodríguez-Tenreiro Sánchez, Federico Martinón-Torres With the increase in the number of routine vaccinations the development of pentavalent and hexavalent combination vaccines fitting the routine vaccination schedules became a necessity. In this respect, Europe has taken the lead in comparison with other world regions, and routine vaccination with pentavalent and hexavalent combinations including DTPa, Hib, HepB and IPV h... περισσότερα »
Knowledge of influenza vaccination recommendation and early vaccination uptake during the 2015–16 season among adults aged ≥18years – United States
[image: S0264410X.gif] Publication date: Available online 1 July 2017 *Source:*Vaccine Author(s): Peng-jun Lu, Anup Srivastav, Tammy A. Santibanez, M. Christopher Stringer, Michael Bostwick, Jill A. Dever, Marshica Stanley Kurtz, Walter W. Williams BackgroundSince 2010, the Advisory Committee on Immunization Practices (ACIP) has recommended that all persons aged ≥6months receive annual influenza vaccination.MethodsWe analyzed data from the 2015 National Internet Flu Survey (NIFS), to assess knowledge and awareness of the influenza vaccination recommendation and early influenza vacci... περισσότερα »
Inferior Limb Salvage by Combined Free-tissue Transfer and the Crane Principle Revisited
[image: image]Summary: Aggressive treatment of ischemia of the lower extremities has decreased the number of amputations in both diabetic and nondiabetic patients; combined vascular reconstruction and microvascular free-flap transfer has been used to improve distal perfusion and cover large tissue defects caused by the critical limb ischemia during the past 30 years. We present our experience with a 71-year-old diabetic patient who underwent revascularization with a vascular bypass and a simultaneous microvascular flap reconstruction for limb salvage after domestic trauma. An extens... περισσότερα »
iTRAQ-based quantitative proteomic analysis reveals multiple effects of Emodin to Haemophilus parasuis
Publication date: Available online 2 July 2017 *Source:*Journal of Proteomics Author(s): Li Li, Ye Tian, Jiankang Yu, Xu Song, Renyong Jia, Qiankun Cui, Wenzhi Tong, Yuanfeng Zou, Lixia Li, Lizi Yin, Xiaoxia Liang, Changliang He, Guizhou Yue, Gang Ye, Ling Zhao, Fei Shi, Cheng Lv, Sanjie Cao, Zhongqiong Yin Haemophilus parasuis, a symbiotic bacteria of upper respiratory tract of swine, is the etiological agent of Glässer's disease, which is characterized by fibrinous polyserositis. Emodin, exhibits antibacterial activity against H. parasuis, yet the action mode has not been fully u...περισσότερα »
Palate perforation differentiates cocaine-induced midline destructive lesions from granulomatosis with polyangiitis.
*Palate perforation differentiates cocaine-induced midline destructive lesions from granulomatosis with polyangiitis.* Acta Otorhinolaryngol Ital. 2017 Jun 30;: Authors: Trimarchi M, Bondi S, Della Torre E, Terreni MR, Bussi M Abstract Cocaine abuse occasionally causes extensive destruction of the osteocartilaginous structures of the nose, sinuses and palate, which mimics the clinical picture of other diseases associated with necrotising midfacial lesions. The differentiation of cocaine-induced midline destructive lesions (CIMDL) and limited granulomatosis with polyangiitis (GPA)...περισσότερα »
Palate perforation differentiates cocaine-induced midline destructive lesions from granulomatosis with polyangiitis.
*Palate perforation differentiates cocaine-induced midline destructive lesions from granulomatosis with polyangiitis.* Acta Otorhinolaryngol Ital. 2017 Jun 30;: Authors: Trimarchi M, Bondi S, Della Torre E, Terreni MR, Bussi M Abstract Cocaine abuse occasionally causes extensive destruction of the osteocartilaginous structures of the nose, sinuses and palate, which mimics the clinical picture of other diseases associated with necrotising midfacial lesions. The differentiation of cocaine-induced midline destructive lesions (CIMDL) and limited granulomatosis with polyangiitis (GPA)...περισσότερα »
Cost-effectiveness strategies in OSAS management: a short review.
*Cost-effectiveness strategies in OSAS management: a short review.* Acta Otorhinolaryngol Ital. 2017 Jun 30;: Authors: Toraldo DM, Passali D, Sanna A, De Nuccio F, Conte L, De Benedetto M Abstract Obstructive sleep apnoea (OSAS) is an underdiagnosed chronic disease with a high prevalence in adults. It is becoming a significant social problem, since it is associated with a worsening in quality of life and increase in mortality. The cost-effectiveness ratio of diagnostic and therapeutic management of OSAS is a strategic issue to counteract the expected increasing demand of objectiv... περισσότερα »
Cost-effectiveness strategies in OSAS management: a short review.
*Cost-effectiveness strategies in OSAS management: a short review.* Acta Otorhinolaryngol Ital. 2017 Jun 30;: Authors: Toraldo DM, Passali D, Sanna A, De Nuccio F, Conte L, De Benedetto M Abstract Obstructive sleep apnoea (OSAS) is an underdiagnosed chronic disease with a high prevalence in adults. It is becoming a significant social problem, since it is associated with a worsening in quality of life and increase in mortality. The cost-effectiveness ratio of diagnostic and therapeutic management of OSAS is a strategic issue to counteract the expected increasing demand of objectiv... περισσότερα »
Prognostic factors in head and neck cancer: a 10-year retrospective analysis in a single-institution in Italy.
*Prognostic factors in head and neck cancer: a 10-year retrospective analysis in a single-institution in Italy.* Acta Otorhinolaryngol Ital. 2017 Jun 30;: Authors: Cadoni G, Giraldi L, Petrelli L, Pandolfini M, Giuliani M, Paludetti G, Pastorino R, Leoncini E, Arzani D, Almadori G, Boccia S Abstract This study was undertaken to evaluate the association between demographics, lifestyle habits, and clinical data and overall survival (OS), recurrence and second primary cancer (SPC) in patients with first primary head and neck cancer (HNC). We retrospectively reviewed data from 482 pat...περισσότερα »
Prognostic factors in head and neck cancer: a 10-year retrospective analysis in a single-institution in Italy.
*Prognostic factors in head and neck cancer: a 10-year retrospective analysis in a single-institution in Italy.* Acta Otorhinolaryngol Ital. 2017 Jun 30;: Authors: Cadoni G, Giraldi L, Petrelli L, Pandolfini M, Giuliani M, Paludetti G, Pastorino R, Leoncini E, Arzani D, Almadori G, Boccia S Abstract This study was undertaken to evaluate the association between demographics, lifestyle habits, and clinical data and overall survival (OS), recurrence and second primary cancer (SPC) in patients with first primary head and neck cancer (HNC). We retrospectively reviewed data from 482 pat...περισσότερα »
Loss of Tyrosine Kinase 2 Does Not Affect the Severity of Jak2V617F-induced Murine Myeloproliferative Neoplasm
Background/Aim: In myeloproliferative neoplasms (MPN), Janus kinase 2 (JAK2) is activated by mutations including JAK2V617F (JAK2VF). It is unclear whether JAK kinases [i.e. JAK1, JAK2, JAK3, or tyrosine kinase 2 (TYK2)] other than JAK2 have cooperative actions such as enhancement or suppression of JAK2. If other kinases enhance activation, therapies that co-target them could have a therapeutic efficacy. We examined the role of TYK2 in Jak2VF-induced murine MPN. Materials and Methods: We crossed Jak2VF transgenic mice and Tyk2-knockout (Tyk2KO) mice to generate Jak2VF/Tyk2KO mice. ... περισσότερα »
Evaluation of a New Technique for iFOBT Utilising a New Sample Collection Device with Increased Buffer Stability
Aims: The aims of the present study were: (i) Evaluate specificity and sensitivity of Hb Smart enzyme-linked immunosorbent assay (ELISA) (ScheBo Biotech) compared to colonoscopy results and (ii) assess stability of a new sample collection device containing a newly formulated buffer to extract haemoglobin using buffer and stool samples spiked with defined concentrations of haemoglobin. Materials and Methods: Stool samples were quantified with the ELISA method. The stability of haemoglobin in the extraction buffer and in native stool samples, respectively, was determined daily by EL... περισσότερα »
Desmoid Tumors in Familial Adenomatous Polyposis
Familial adenomatous polyposis (FAP) is a cancer syndrome caused by a germline mutation in the adenomatous polyposis coli (APC) gene. It is characterized by the presence of hundreds of colonic polyps, which have a high tendency to undergo malignant transformation. Among associated lesions in FAP, desmoid tumors represent a common possible life-threatening condition that requires special attention. They are rare tumors occurring with a particularly high incidence in FAP, especially after surgery. In agreement with Knudson's 'two-hit' theory, the inactivation of the residual APC gen...περισσότερα »
Serum Heparin-binding Epidermal Growth Factor-like Growth Factor (HB-EGF) as a Biomarker for Primary Ovarian Cancer
Ovarian cancer is the most lethal malignancy among gynaecological cancers. Although many anticancer agents have been developed for the treatment of ovarian cancer, it continues to have an extremely poor prognosis. Heparin-binding epidermal growth factor-like grown factor (HB-EGF) has been reported to be a rational therapeutic target for ovarian cancer. Here, we evaluated the clinical significance of serum HB-EGF by examining the association between prognosis and serum HB-EGF levels in patients with primary ovarian cancer. We found that high serum HB-EGF concentrations were signifi... περισσότερα »
Application of Cancer Cell Reprogramming Technology to Human Cancer Research
The cancer stem cell (CSC) hypothesis is an evolving concept of oncogenesis that has recently gained wide acceptance. By definition, CSCs exhibit continuous proliferation and self-renewal, and they have been proposed to play significant roles in oncogenesis, tumor growth, metastasis, chemoresistance, and cancer recurrence. The reprogramming of cancer cells using induced pluripotent stem cell (iPSC) technology is a potential strategy for the identification of CSC-related oncogenes and tumor-suppressor genes. This technology has some advantages for studying the interactions between ... περισσότερα »
Hepatitis B Reactivation in a Patient Receiving Chemotherapy for Breast Cancer: A Case Report
Hepatitis B virus (HBV) reactivation is a known complication of immunosuppressive therapy. While patients who are undergoing treatment with anti-CD20 agents or stem cell transplantation are commonly screened for chronic HBV infection prior to treatment, there are no consensus guidelines regarding HBV screening for patients undergoing chemotherapy for solid tumors. We present a rare case of fulminant liver failure due to HBV reactivation in a patient receiving chemotherapy for breast cancer. Our case highlights the importance of developing definitive guidelines regarding HBV screen... περισσότερα »
Clinical Implications of Augmenter of Liver Regeneration in Cancer: A Systematic Review
Background/Aim: Hepatocellular carcinoma is a substantial healthcare burden with high prevalence and poor prognosis. As such, efforts are continually made to uncover molecules relevant in cancer biology, that are exploitable as targets for therapy. The mitochondrion is the powerhouse of the cell and exhibits altered functionality in the malignant state, including aberrant regulation of apoptosis and cellular respiration. Augmenter of liver regeneration (ALR) is a multifunctional mitochondrial protein that demonstrates anti-oxidative and anti-apoptotic properties and plays a key ro...περισσότερα »
Measurement of the Phagocytic Activity of Human Peripheral Blood Using a Highly Sensitive Fluorometric Detection Device Without Hemolysis
Background/Aim: Phagocytes recognize pathogens that enter the body as well as other abnormal and foreign materials that may exist within an organism (such as dead cells, oxidized lipids, and denatured proteins), and phagocytose and eliminate them to maintain a healthy state. In a previous study a simple prototype device was used, under development by Hamamatsu Photonics (Prototype), that detects fluorescence to determine the phagocytic activity of the murine macrophage cell line J774.1. The present study aimed to determine whether it was possible to detect phagocytic activity in a... περισσότερα »
Inhibition of ERG Activity in Patient-derived Prostate Cancer Xenografts by YK-4-279
Background/Aim: The aim of the current study was to determine the effects of the ERG small-molecule inhibitor YK-4-279 on ERG+ prostate cancer patient-derived xenografts (PDX). Materials and Methods: ERG activity was blocked using YK-4-279 in three subcutaneously-implanted ERG+ (LuCaP 23.1, 86.2 and 35) and one ERG– (LuCaP 96) PDX. Treated animals tumor volume (TV), body weight (BW) and serum prostate-specific antigen (PSA) were compared to vehicle-treated control animals. Gene expression, proliferation, apoptosis, microvessel density and ERG expression were also assessed. Results... περισσότερα »
Axitinib for Gemcitabine-refractory Advanced Biliary Tract Cancer: Report of 5 Cases
Background/Aim: Vascular endothelial growth factor receptor (VEGFR) has been identified as a treatment target for biliary tract cancer (BTC) and axitinib is a selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-1/2/3. This study was conducted as a preliminary evaluation of the safety and efficacy of axitinib for patients with advanced BTC. Patients and Methods: Patients refractory to gemcitabine-based regimens were administered axitinib at the dose of 5 mg twice daily. Results: Five patients (3 male and 2 female) with a median age of 68 years were enrolled. ... περισσότερα »
A Novel mTOR Inhibitor; Anthracimycin for the Treatment of Human Hepatocellular Carcinoma
Background/Aim: Anthracimycin, a secondary metabolite of Streptomyces, has been shown to inhibit the invasion of certain cancer cell lines. Materials and Methods: In this study we evaluated the effect of anthracimycin on cell growth and signaling pathways in hepatocellular carcinoma (HCC). Results: Anthracimycin suppressed cell proliferation and motility and induced apoptosis in human HCC cell lines. Furthermore, anthracimycin had no effect on the enrichment of EpCAM-high liver cancer stem cells (CSCs), while fluorouracil dramatically enriched the CSCs with activation of the stemn...περισσότερα »
Impact and Prediction of Lymph Node Involvement in Patients with Intrahepatic Cholangiocarcinoma After Curative Resection
Background: The aim of this study was to identify the preoperative predictors of prognosis in patients with intrahepatic cholangiocarcinoma (ICC) undergoing resection. Patients and Methods: We enrolled 90 patients with ICC who underwent surgical resection, including 59 in whom surgery was considered curative, and measured the overall survival (OS), recurrence-free survival (RFS), and other outcomes and potential prognostic factors. Results: Multivariate Cox proportional hazards analysis showed that tumor in the resection margins (R>0) independently predicted long-term OS in the wh... περισσότερα »
Patient-derived Xenografts from Colorectal Carcinoma: A Temporal and Hierarchical Study of Murine Stromal Cell Replacement
Background/Aim: Patient-derived xenografting (PDX) of human colorectal cancer (CRC) is the preferred experimental model to study tumor response to therapeutic agents. Gradually, human stromal cells are replaced by mouse stromal cells; however, the exact timing of the replacement of human with murine stromal cells in human CRC xenograft has not been fully elucidated. We hypothesize that orthologous murine transcripts functionally substitutes for the loss due to replacement of human stromal genes. Materials and Methods: Human CRC were implanted in athymic nude mice in replicates and ... περισσότερα »
Factors Influencing Disease Progression in Patients with Head and Neck Melanoma
Background: Histological parameters as well as the status of sentinel lymph node are known to be strong prognostic factors in patients with melanoma. Patients and Methods: In this study, we retrospectively analyzed 1,384 patients who were diagnosed with head and neck melanoma between 1976 and 2010 regarding prognostic factors [tumor thickness, level of invasion, sentinel lymph node (SLN) status, ulceration, histological subtype, localization, and gender], overall survival, and disease-free survival. Results: Patients who developed metastases had a significantly thicker tumor than ... περισσότερα »
Effect of Lonidamine on Systemic Therapy of DB-1 Human Melanoma Xenografts with Temozolomide
Background/Aim: Since temozolomide (TMZ) is activated under alkaline conditions, we expected lonidamine (LND) to have no effect or perhaps diminish its activity, but initial results suggest it may actually enhance either or both short- and long-term activity of TMZ in melanoma xenografts. Materials and Methods: Cohorts of 5 mice with subcutaneous xenografts ~5 mm in diameter were treated with saline (control (CTRL)), LND only, TMZ only or LND followed by TMZ at t=40 min (time required for maximal tumor acidification). Results: Mean tumor volume for LND+TMZ for the period between 6... περισσότερα »
Efficacy of Combination Therapy with MET and VEGF Inhibitors for MET-overexpressing Glioblastoma
Background: Glioblastoma multiforme (GBM) is a malignant brain tumor with an extremely poor prognosis. GBM tissues frequently express mesenchymal–epithelial transition factor (MET), which induces cell division, growth and migration. In addition, angiogenesis is a significant feature of GBM, attributable to the overexpression of vascular endothelial growth factor (VEGF). Although the VEGF inhibitor bevacizumab was recently highlighted as the second-line drug for GBM treatment, GBMs often recur even with bevacizumab therapy. Based on these findings, we hypothesized that inhibition o... περισσότερα »
Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-{beta}-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma
Background: Renal oncocytomas (ROs), and clear cell (RCC) and urothelial carcinomas (UC), are common renal neoplasms. Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step of NAD+ synthesis and its expression is increased in several tumors. Nampt concomitantly regulates hydrogen sulfide (H2S)-synthesizing enzyme levels, including cystathionine-β-synthase (CBS). Materials and Methods: We used tissue microarrays to examine Nampt and the H2S-synthesizing enzyme CBS protein levels in benign kidney, RCC, UC and ROs. Results: Compared to benign kidney, all thre... περισσότερα »
Systemic Intravenous Adoptive Transfer of Autologous Lymphokine-activated {alpha}{beta} T-Cells Improves Temozolomide-induced Lymphopenia in Patients with Glioma
In this clinical study, we investigated the safety and clinical usefulness of systemic adoptive immunotherapy using autologous lymphokine-activated αβ T-cells (αβ T-cells), combined with standard therapies, in patients with malignant brain tumors. Twenty-three patients with different malignant brain tumors, consisting of 14 treated with temozolomide (TMZ group) and 9 treated without temozolomide (non-TMZ group), received systemic intravenous injections of αβ T-cells (mean=10.4 injections/patient for the TMZ group, and 4.78 for the non-TMZ group). No significant adverse effects asso... περισσότερα »
Choline-Deficient-Diet-Induced Fatty Liver Is a Metastasis-Resistant Microenvironment
Background/Aim: Fatty liver disease is increasing in the developed and developing world. Liver metastasis from malignant lymphoma in the fatty liver is poorly understood. In a previous report, we developed color-coded imaging of the tumor microenvironment (TME) of the murine EL4-RFP malignant lymphoma during metastasis, including the lung. In the present report, we investigated the potential and microenvironment of the fatty liver induced by a choline-deficient diet as a metastatic site in this mouse lymphoma model. Materials and Methods: C57BL/6-GFP transgenic mice were fed with a... περισσότερα »
An aspect of the object habit: Pliny the Elder, audience and politics
Libonati, E; (2017) An aspect of the object habit: Pliny the Elder, audience and politics. Museum History Journal pp. 1-13. 10.1080/19369816.2017.1328791 . http://ift.tt/2t4UZvU
Consensus-based guidelines for Video EEG monitoring in the pre-surgical evaluation of children with epilepsy in the UK.
Pressler, RM; Seri, S; Kane, N; Martland, T; Goyal, S; Iyer, A; Warren, E; Pressler, RM; Seri, S; Kane, N; Martland, T; Goyal, S; Iyer, A; Warren, E; Notghi, L; Bill, P; Thornton, R; Appleton, R; Doyle, S; Rushton, S; Worley, A; Boyd, SG; CESS Clinical Neurophysiology working group, ; - view fewer (2017) Consensus-based guidelines for Video EEG monitoring in the pre-surgical evaluation of children with epilepsy in the UK. Seizure , 50 pp. 6-11. 10.1016/j.seizure.2017.05.008 . http://ift.tt/2sAfMnu
Calling all health professionals for a safer, fairer and better world
De C Williams, AC; Orlowska, D; (2014) Calling all health professionals for a safer, fairer and better world. Psychologist , 27 (2) 67-. http://ift.tt/2t5djVS
Invasion of the bloggers: A preliminary study on the demography and content of the economic blogosphere
Mata, T; (2011) Invasion of the bloggers: A preliminary study on the demography and content of the economic blogosphere. In: The Elgar Companion to Recent Economic Methodology. (pp. 514-524). http://ift.tt/2sAj7D0
Opicapone for the management of end-of-dose motor fluctuations in patients with Parkinson's disease treated with L-DOPA.
Lees, AJ; Ferreira, J; Rascol, O; Reichmann, H; Stocchi, F; Tolosa, E; Poewe, W; (2017) Opicapone for the management of end-of-dose motor fluctuations in patients with Parkinson's disease treated with L-DOPA. Expert Rev Neurother , 17 (7) pp. 649-659. 10.1080/14737175.2017.1336086 . http://ift.tt/2t4Z2Z1
The relationship between the First World War and neurology: 100 years of "Shell Shock".
Pedroso, JL; Linden, SC; Barsottini, OG; Maranhão, P; Lees, AJ; (2017) The relationship between the First World War and neurology: 100 years of "Shell Shock". Arq Neuropsiquiatr , 75 (5) pp. 317-319. 10.1590/0004-282X20170046 . http://ift.tt/2sADW1j
Influence of the drug distribution in electrospun gliadin fibers on drug-release behavior.
Xu, Y; Li, J-J; Yu, D-G; Williams, GR; Yang, J-H; Wang, X; (2017) Influence of the drug distribution in electrospun gliadin fibers on drug-release behavior. Eur J Pharm Sci , 106 pp. 422-430. 10.1016/j.ejps.2017.06.017 . http://ift.tt/2t4U7Y9
Finding the grave of Sir William Richard Gowers.
Boes, CJ; Toodayan, N; Lees, A; (2017) Finding the grave of Sir William Richard Gowers. Pract Neurol 10.1136/practneurol-2017-001648 . http://ift.tt/2sAJqZU
Concerns Regarding Opicapone as Adjunct to Levodopa Therapy-Reply.
Lees, AJ; Rocha, J-F; Soares-da-Silva, P; (2017) Concerns Regarding Opicapone as Adjunct to Levodopa Therapy-Reply. JAMA Neurol 10.1001/jamaneurol.2017.0726 . http://ift.tt/2t51pvb
Association of Autonomic Dysfunction With Disease Progression and Survival in Parkinson Disease.
De Pablo-Fernandez, E; Tur, C; Revesz, T; Lees, AJ; Holton, JL; Warner, TT; (2017) Association of Autonomic Dysfunction With Disease Progression and Survival in Parkinson Disease. JAMA Neurol 10.1001/jamaneurol.2017.1125 . http://ift.tt/2sAifOH
Time from HIV seroconversion to death: a collaborative analysis of eight studies in six low and middle-income countries before highly active antiretroviral therapy
Todd, J; Glynn, JR; Marston, M; Lutalo, T; Biraro, S; Mwita, W; Suriyanon, V; Todd, J; Glynn, JR; Marston, M; Lutalo, T; Biraro, S; Mwita, W; Suriyanon, V; Rangsin, R; Nelson, KE; Sonnenberg, P; Fitzgerald, D; Karita, E; Żaba, B; - view fewer (2007) Time from HIV seroconversion to death: a collaborative analysis of eight studies in six low and middle-income countries before highly active antiretroviral therapy. AIDS , 21 (Suppl 6) S55-S63. 10.1097/01.aids.0000299411.75269.e8 . http://ift.tt/2t52FOO
Classification of drug-resistant tuberculosis.
Sonnenberg, P; Godfrey-Faussett, P; Glynn, JR; Shearer, S; Murray, J; (2000) Classification of drug-resistant tuberculosis. Lancet , 356 (9245) pp. 1930-1931. 10.1016/S0140-6736(05)73482-6 . http://ift.tt/2sAyTO9
Cause of death and presence of respiratory disease at autopsy in an HIV-1 seroconversion cohort of southern African gold miners
Murray, J; Sonnenberg, P; Nelson, G; Bester, A; Shearer, S; Glynn, JR; (2007) Cause of death and presence of respiratory disease at autopsy in an HIV-1 seroconversion cohort of southern African gold miners. AIDS , 21 (Suppl 6) S97-S104. 10.1097/01.aids.0000299416.61808.24 . http://ift.tt/2t4XFJM
Estimating 'net' HIV-related mortality and the importance of background mortality rates
Marston, M; Todd, J; Glynn, JR; Nelson, KE; Rangsin, R; Lutalo, T; Urassa, M; Marston, M; Todd, J; Glynn, JR; Nelson, KE; Rangsin, R; Lutalo, T; Urassa, M; Biraro, S; Van der Paal, L; Sonnenberg, P; Żaba, B; - view fewer (2007) Estimating 'net' HIV-related mortality and the importance of background mortality rates. AIDS , 21 (Suppl 6) S65-S71. 10.1097/01.aids.0000299412.82893.62 . http://ift.tt/2sAbwVc
The Long-term Effects of Early Track Choice
Dustmann, C; Puhani, PA; Schönberg, U; (2017) The Long-term Effects of Early Track Choice. Economic Journal 10.1111/ecoj.12419 . (In press). http://ift.tt/2t57sQa
Buckling in armored droplets.
Sicard, F; Striolo, A; (2017) Buckling in armored droplets. Nanoscale , 9 (25) pp. 8567-8572. 10.1039/c7nr01911d . http://ift.tt/2sAidGz
Water Oxidation Kinetics of Accumulated Holes on the Surface of a TiO 2 Photoanode: A Rate Law Analysis
Kafizas, A; Ma, Y; Pastor, E; Pendlebury, SR; Mesa, C; Francàs, L; Le Formal, F; Kafizas, A; Ma, Y; Pastor, E; Pendlebury, SR; Mesa, C; Francàs, L; Le Formal, F; Noor, N; Ling, M; Sotelo-Vazquez, C; Carmalt, CJ; Parkin, IP; Durrant, JR; - view fewer (2017) Water Oxidation Kinetics of Accumulated Holes on the Surface of a TiO 2 Photoanode: A Rate Law Analysis. ACS Catalysis pp. 4896-4903. 10.1021/acscatal.7b01150 . http://ift.tt/2t4ZUwZ
Late recovery of awareness in prolonged disorders of consciousness -a cross-sectional cohort study.
Yelden, K; Duport, S; James, LM; Kempny, A; Farmer, SF; Leff, AP; Playford, ED; (2017) Late recovery of awareness in prolonged disorders of consciousness -a cross-sectional cohort study. Disabil Rehabil pp. 1-6. 10.1080/09638288.2017.1339209 . http://ift.tt/2sA6KH2
Endoscopic Depth Measurement and Super-Spectral-Resolution Imaging
Lin, J; Clancy, NT; Hu, Y; Qi, J; Tatla, T; Stoyanov, D; Maier-Hein, L; Lin, J; Clancy, NT; Hu, Y; Qi, J; Tatla, T; Stoyanov, D; Maier-Hein, L; Elson, DS; - view fewer Endoscopic Depth Measurement and Super-Spectral-Resolution Imaging. http://ift.tt/2t4PYDp
Fast Estimation of Haemoglobin Concentration in Tissue Via Wavelet Decomposition
Jones, G; Clancy, NT; Du, X; Robu, M; Arridge, S; Elson, DS; Stoyanov, D; Fast Estimation of Haemoglobin Concentration in Tissue Via Wavelet Decomposition. http://ift.tt/2sAeZDi
The Effects of Cognitive Reappraisal on Conditioned Disgust in Contamination-based OCD: An Analogue Study
[image: S08876185.gif] Publication date: Available online 1 July 2017 *Source:*Journal of Anxiety Disorders Author(s): Bunmi O. Olatunji, Hannah Berg, Rebecca C. Cox, Amber Billingsley Experimental research has shown that conditioned disgust is resistant to extinction, which may account for the slower habituation to disgust relative to fear in contamination-based obsessive-compulsive disorder (OCD). However, few studies have examined the efficacy of interventions that may attenuate conditioned disgust responses. Studies of cognitive reappraisal have demonstrated that reinterpreting a... περισσότερα »
Meditation is associated with increased brain network integration
[image: S10538119.gif] Publication date: September 2017 *Source:*NeuroImage, Volume 158 Author(s): Remko van Lutterveld, Edwin van Dellen, Prasanta Pal, Hua Yang, Cornelis Jan Stam, Judson Brewer IntroductionThis study aims to identify novel quantitative EEG measures associated with mindfulness meditation. As there is some evidence that meditation is associated with higher integration of brain networks, we focused on EEG measures of network integration.MethodsSixteen novice meditators and sixteen experienced meditators participated in the study. Novice meditators performed a basic m... περισσότερα »
ALEXANDROS G. SFAKIANAKIS,Anapafseos 5 Agios Nikolaos Crete 72100 Greece,00302841026182,00306932607174,alsfakia@gmail.com
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Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
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heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
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