Αρχειοθήκη ιστολογίου

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Πέμπτη 11 Νοεμβρίου 2021

Sensitivity of Communicative Participation Item Bank for Measuring Unilateral Vocal Fold Immobility

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This case series examines differences in patients' score s on the Communicative Participation Item Bank before and after treatment of unilateral vocal fold immobility and how the scores compare with qualitative self-reports of treatment outcomes.
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Cystic Neck Mass

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A 44-year-old woman presented with a 6-month history of a right neck mass with compressive symptoms. What is your diagnosis?
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Clinical Staging to Estimate the Probability of Postoperative Complications in Vestibular Schwannoma

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This cohort study presents a staging system to predict se vere surgical complications in patients who undergo surgical resection of vestibular schwannoma.
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An Unusual Case of Bilateral Chylothorax After Neck Dissection

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This case report describes a woman in her 30s who underwe nt total thyroidectomy with modified radical neck dissection due to papillary thyroid cancer and was subsequently diagnosed with bilateral chylothorax secondary to cervical thoracic duct injury.
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Hearing Loss and Impaired Physical Function, Frailty, and Disability in Older Adults

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This cross-sectional study examines the association betwe en hearing loss and impaired lower extremity function, frailty syndrome, and disability in older adults.
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Long-term Outcomes of Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea

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This cohort study investigates the association between long-te rm use of hypoglossal nerve stimulation for obstructive sleep apnea and improved patient-reported outcomes, particularly insomnia and depression indices, and compares these outcomes with those for positive airway pressure therapy.
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Superiority of sucrase-isomaltase to CD10 for immunohistochemical detection of intestinal absorptive cell phenotype in differentiated-type gastric adenocarcinoma

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Int J Clin Exp Pathol. 2021 Oct 15;14(10):1031-1037. eCollection 2021.

ABSTRACT

Gastric adenocarcinoma (GAC) can be divided immunophenotypically into gastric, intestinal, or mixed gastric and intestinal phenotypes. Cadherin 17 (CDH17) and CD10 have been used as comprehensive markers for intestinal epithelial cells and for small intestinal absorptive cells in GACs, respectively. Sucrase-isomaltase (SI) and CD10 are expressed in small intestinal absorptive cells and SI is more frequently expressed than CD10 in gastric intestinal metaplasia (IM). The aim of this study was to evaluate the potential of SI as a marker for intestinal absorptive cells compared to CD10 in differentiated-type (DT) GACs. We compared the immunohistochemical expression of CDH17, SI, and CD10 in IMs and tissue microarrays of 40 samples of DTGACs. In IMs and DTGACs, CDH17 showed a diffuse lateral cytoplasmic membrane staining both in columnar and goblet cells. SI and CD10 were expressed on the luminal surfaces of the columnar cells. In IMs, SI was positive both in both complete-type IMs and in incomplete-type IMs. CD10 was positive only in complete-type IMs. In DTGACs, CDH17, SI, and CD 10 were positive in 37 (92.5%), 22 (55%), and 11 (27.5%) cases, respectively. In SI-positive cases, the degrees of expression of SI were equal to (7 cases) or less than (15 cases) those of CDH17; the degrees of expression of SI were equal to (5 cases), more than (16 cases), or less than (1 case) those of CD10. In conclusion, SI is a more sensitive immunohistochemical marker for intestinal absorptive cells than CD10 in DTGACs.

PMID:34760039 | PMC:PMC8569310

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Combined CT score, blood mononuclear cell count, LDH, and plasma D-dimer for viral pneumonia diagnosis: a retrospective study

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Int J Clin Exp Pathol. 2021 Oct 15;14(10):1022-1030. eCollection 2021.

ABSTRACT

OBJECTIVE: Due to a continued increase in viral pneumonia incidence and resulting high mortality, fast and accurate diagnosis is important for effective management. This investigation examined the significance of blood biomarkers and the CT score in the early diagnosis of viral pneumonia.

METHODS: Patients who were hospitalized due to radiologically-confirmed pneumonia and underwent virus antigen rapid test were enrolled. Their clinical information was compared. Blood mononuclear cell count, LDH, and plasma D-dimer were obtained. To evaluate the utility of biomarker levels in differentiating viral pneumonia from other pneumonia, ROC curves were developed to analyze the AUC. The optimal cut-off thresholds, specificity, sensitivity, and predictive values were assessed using the Youden index. The added value of the multi-marker approach was delineated us ing IDI and Reclassification analyses using NRI; IDI and NRI values were examined with 95% CI.

RESULTS: Overall, 1163 inpatients were recruited between January 2017 and January 2021. They were sub-divided into the viral pneumonia (n = 563) and non-viral pneumonia (n = 600) categories. We found that the CT score, blood mononuclear cell count, LDH, and plasma D-dimer were markedly elevated in viral pneumonia patients. At an LDH threshold of 693.595 U/L, an AUC of ROC was 0.805 in differentiating viral pneumonia. The combination of CT score and blood biomarkers had an ROC AUC value of 0.908.

CONCLUSIONS: Combining elevated biomarkers with CT assessments outperformed the CT score alone in identifying viral pneumonia. It is crucial to better characterize the significance of biomarkers in combination with CT assessments in the diagnosis of viral pneumonia.

PMID:34760038 | PMC:PMC8569312

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Minimal Extrathyroidal Extension Does Not Predict Initial Treatment Response, but Is a Better Prognostic Factor when Combined with Tumor Size

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Clinical Thyroidology, Volume 33, Issue 11, Page 493-496, November 2021.
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What Are the Implications of Isolated Maternal Hypothyroxinemia in Early Pregnancy?

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Clinical Thyroidology, Volume 33, Issue 11, Page 470-473, November 2021.
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Overt Hyperthyroidism May Be a Good Prognostic Sign in Immune Checkpoint Inhibitor Treatment

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Clinical Thyroidology, Volume 33, Issue 11, Page 467-469, November 2021.
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What Is the Optimal Imaging Modality for Parathyroid Adenoma?

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