Elevated soluble CD23 level indicates increased risk of B cell non-Hodgkin’s lymphomas: evidence from a meta-analysis

Abstract

The aim of the present study was to determine whether circulating soluble CD23 (sCD23) was associated with B cells non-Hodgkin's lymphomas (B-NHL). PubMed, EMBASE, and ISI Web of Science were extensively searched without language restriction. Data was extracted in a standardized data collection sheet after two reviewers scanned studies independently. The association between sCD23 and NHL was indicated as odds ratio (OR) along with its related 95% confidence interval (95% CI). Meta-analysis was conducted via RevMan 5.3. A total of five studies, which included 964 B-NHL patients and 1243 matched controls without B-NHL, among which 257 were HIV-positive donors and 986 were general controls, were included in our study. Meta-analysis revealed a significant association between peripheral sCD23 level and B-NHL in HIV-positive samples (OR 1.66, 95% CI 1.25, 2.20; P = 0.0005) as well as the general population (OR 2.51; 95% CI 1.71, 3.86; P < 0.00001). Meta-analysis, stratified by sampling time prior to diagnosis, indicated potential HIV-NHL patients are 2.34-folds more likely to have higher blood sCD23 level, although this association is statistically meaningful only during 3–5 years prior to diagnosis (95% CI 1.27, 4.33). Subgroup analysis based on B-NHL type demonstrated a significant association between sCD23 level and diffuse large B cell lymphoma (DLBCL), chronic lymphocytic leukemia (CLL), and follicular lymphoma (FL). The findings of our study indicate a positive association of circulating sCD23 level and B-NHL risks and highlight the possibility of sCD23 as a predictive marker of B-NHL. However, to better understand the underlying mechanism, further studies are needed.

https://ift.tt/2tzbDCR

Impact of hematopoietic stem cell transplantation in patients with relapsed or refractory mantle cell lymphoma

Abstract

Rituximab has been shown to improve outcomes in patients with B-cell lymphoma. However, patients with relapsed or refractory (R/R) mantle cell lymphoma (MCL) still have a poor prognosis, and the choice between high-dose therapy with autologous hematopoietic cell transplantation (HCT) and allogeneic HCT remains controversial in these patients. We retrospectively analyzed the risk factors for outcomes in 162 R/R MCL patients who received autologous (n = 111) or allogeneic (n = 51) HCT between 2004 and 2014. The median overall survival (OS) rates were 48 and 65 months in the autologous and allogeneic HCT groups, respectively (P = 0.20). Significant risk factors for overall survival in R/R MCL patients after autologous HCT were > 60 years of age at HCT (P = 0.017), higher score of HCT-specific comorbidity index at HCT (P = 0.033), and receiving MCEC (ranimustine + carboplatin + etoposide + cyclophosphamide) regimen (P = 0.017), while higher performance status at HCT (P = 0.011) and longer interval from diagnosis to HCT (P = 0.0054) were risk factors after allogeneic HCT. Strategies that carefully select R/R MCL patients for autologous HCT may allow the identification of individuals suitable for allogeneic HCT.

https://ift.tt/2lwGFYo

Significance of circulating Epstein-Barr virus DNA monitoring after remission in patients with extranodal natural killer T cell lymphoma

Abstract

Circulating Epstein-Barr virus (EBV)-DNA has been established as a useful parameter for diagnosis and predicting prognosis in patients with extranodal natural killer T cell lymphoma (ENKTL); however, the role of monitoring of circulating EBV-DNA after complete remission (CR) is not well established. From January 2008 to August 2016, 328 ENKTL patents were enrolled in 2 lymphoma cohorts. Of 171 patients achieved a CR, 81 had available monitoring data for circulating EBV-DNA with negative post-treatment EBV-DNA. Measurement of circulating EBV-DNA was performed from unfractionated whole blood and calculated according to WHO international standards. Median duration of follow-up was 40.4 months. In 31 of the 81 patients (38.8%), circulating EBV-DNA was detected at least once during follow-up, and 16 of these patients (51.6%) experienced relapse. In contrast, only 7 out of 50 (14.0%) patients with consistently undetectable circulating EBV-DNA experienced relapse (p < 0.001). In multivariate analysis, positive conversion of circulating EBV-DNA was the only independent prognostic factor for occurrence of relapse (HR = 6.552, p < 0.001), progression-free survival (HR = 4.549, p = 0.01), and overall survival (HR = 8.726, p < 0.001). Patients with a higher level of circulating EBV-DNA than 3310 IU/mL (3.52 log₁₀ IU/mL) showed a strong tendency to relapse (73.3 vs. 31.3%, p = 0.019). In conclusion, positive conversion of circulating EBV-DNA was a valuable indicator of relapse and inferior survival, especially if the level was higher than 3310 IU/mL in ENKTL patients had achieved CR. Close follow-up is necessary for patients developed detectable circulating EBV-DNA after remission.

https://ift.tt/2yES2XG

IgG synthesis rate and anti-myelin oligodendrocyte glycoprotein antibody in CSF may be associated with the onset of CNS demyelination after haplo-HSCT

Abstract

Haploidentical hematopoietic stem cell transplant (haplo-HSCT) is an upfront and effective therapy for hematology patients, but it usually has many complications, such as neurological complications. As one of the neurological complications following haplo-HSCT, immune-mediated demyelinating diseases of the central nervous system (CNS) seriously affect a patient's quality of life. However, the incidence, risk factors, and pathogenesis of CNS demyelination are not very well understood. Thirty of the 1526 patients (1.96%) suffered from CNS demyelination. In univariate analysis, we found that blood-brain barrier (BBB) permeability and the CSF IgG synthesis index (IgG-Syn) were related to the occurrence of CNS demyelination (p < 0.05). In a multivariate analysis, the IgG-Syn (OR = 1.017, 95% CI 1.003–1.031, p = 0.019) and CSF anti-myelin oligodendrocyte glycoprotein antibody (MOG.Ab) (OR = 12.059, 95% CI 1.141–127.458, p = 0.038) were independently associated with the onset of CNS demyelination. We also studied the possible pathogenesis of CNS demyelination. Immune reconstitution (the cell proportions of CD19⁺ B cells, CD3⁺ T cells, and CD4⁺ T cells); the counts of leucocytes, lymphocytes, monocytes, and platelets; and the levels of immunoglobulins A, G, and M 30, 60, and 90 days after HSCT showed no significant differences between CNS demyelination and no demyelination (p > 0.05). The probabilities of overall survival showed no significant differences between patients with and without demyelination (p > 0.05). Only four deaths in 30 patients, but bringing projected survival to less than 20%.We imply that IgG-Syn and CSF MOG. Ab may be associated with the onset of CNS demyelination during 2 weeks of neurological symptoms in patients with brain or spinal cord MRI abnormality. Immune reconstitution may not be the pathogenesis of CNS demyelination.

https://ift.tt/2luBMz7

Bendamustine plus rituximab for relapsed or refractory diffuse large B cell lymphoma: a multicenter retrospective analysis

Abstract

Bendamustine plus rituximab (BR) showed efficacy and safety in indolent lymphomas and mantle cell lymphoma. However, there were limited experiences of real-world practice of BR in diffuse large B cell lymphoma (DLBCL). In this study, we report the Korean experiences with BR in relapsed or refractory DLBCL who are not eligible for intensive chemotherapy and autologous stem cell transplantation. This is an observational, multicenter, retrospective analysis. Between December 2011 and December 2015, a total of 58 patients with relapsed or refractory DLBCL were treated with BR in 11 tertiary hospitals in Korea. Patients received an intravenous (IV) infusion of rituximab at a dose of 375 mg/m² on day 1. On days 2 and 3, patients received an IV infusion of bendamustine at doses of 120 or 90 mg/m². Median age was 69 (range 18–86), 74.1% had stage III or IV disease, and 67.2% showed high-intermediate or high International Prognostic Index scores at diagnosis. In an intention-to-treat analysis, 18 patients (31.0%) showed a complete response and 14 (24.1%) showed a partial response, resulting in an overall response rate of 55.1%. The median duration of the response was 3.7 months (range 1.0–47.2 months). The median progression-free survival was 3.9 months (95% confidence interval [CI], 2.4–5.4 months), and the median overall survival was 6.7 months (95% CI, 4.7–8.7 months). The most common grade 3/4 adverse event was neutropenia (n = 40; 68.9%). Febrile neutropenia was observed in 11 patients (18.9%). Grade 3/4 thrombocytopenia was observed in 34 patients (58.6%). Our study confirmed the high efficacy and acceptable toxicity profile of BR in relapsed or refractory DLBCL patients. However, we need to closely observe the higher tendency of grade 3/4 hematological toxicities in Korean patients.

https://ift.tt/2yG6grb

Late-onset hemophagocytic lymphohistiocytosis with varicella zoster virus and Epstein-Barr virus co-infection after umbilical cord blood transplantation

https://ift.tt/2lwGDQg

A patient with B-cell acute lymphoblastic leukemia with PAX5-ETV6 rearrangement with dic(9;12)(p13;p13) identified by chromosomal microarray

https://ift.tt/2yOB6OL

Large granular lymphocytic leukemia-associated peripheral neuropathy

https://ift.tt/2lwyo6H

BAALC and ERG expression levels at diagnosis have no prognosis impact on acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation

Abstract

Brain and acute leukemia, cytoplasmic (BAALC) and ETS-related gene (ERG) expression levels are independent prognostic factors for acute myeloid leukemia (AML); however, their prognostic impacts on AML patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) require further investigation. We studied 71 de novo AML patients treated with allo-HSCT and defined low and high expressers according to the median expression levels of BAALC and ERG at diagnosis respectively. High BAALC expression was associated with wild-type NPM1 (P = 0.000) and RUNX1 mutations (P = 0.027). High ERG expression was associated with FLT3-ITD absence (P = 0.003) and wild-type NPM1 (P = 0.001). BAALC and ERG expression levels were significantly correlated with each other (P = 0.001). Survival analyses including Kaplan-Meier curves and univariate and multivariate analysis consistently reported that there were no significant differences for both event-free survival (EFS) and overall survival (OS) (all P > 0.1), between high versus low BAALC and ERG expressers. Our study suggested that despite of their well-known adverse role in prognosis of AML, neither BAALC nor ERG expression levels at diagnosis had effect on survival of AML patients who underwent allo-HSCT.

https://ift.tt/2tBp999

Efficacy and safety of decitabine against cutaneous granuloblastic sarcoma: a case report

https://ift.tt/2lwGFaQ

The severe cytokine release syndrome in phase I trials of CD19-CAR-T cell therapy: a systematic review

Abstract

CD19 chimeric antigen receptor (CAR) T cell therapy has shown impressive results in treating acute lymphoblastic leukemia (B-ALL), chronic lymphoblastic leukemia (B-CLL), and B-cell non-Hodgkin lymphoma (B-NHL) over the past few years. Meanwhile, the cytokine release syndrome (CRS), which could be moderate or even life-threatening, has emerged as the most significant adverse effect in the clinical course of this novel targeting immunotherapy. In this systematic review, we analyzed the incidence of severe CRS in 19 clinical trials selected from studies published between 2010 and 2017. The pooled severe CRS proportion was 29.3% (95% confidence interval [CI] 12.3–49.1%) in B-ALL, 38.8% (95%CI 12.9–67.6%) in B-CLL, and 19.8% (95%CI 4.2–40.8%) in B-NHL. In the univariate meta regression analysis, the proliferation of CD19-CAR-T cell in vivo was correlated with the severe CRS. Specifically, total infusion cell dose contributed to the severe CRS occurring in B-ALL patients but not in B-CLL or B-NHL patients. Tumor burden was strongly associated with the severity of CRS in B-ALL. Besides, post-HSCT CD19 CAR-T cell infusion represented lower severe CRS incidence. Further investigations into the risk factors of CRS in B-CLL and B-NHL are needed.

https://ift.tt/2yEavUb

Eculizumab treatment for ischemic enteritis accompanied with paroxysmal nocturnal hemoglobinuria: a case report and literature review

https://ift.tt/2lvVIBG

Autoimmune disorders are common in myelodysplastic syndrome patients and confer an adverse impact on outcomes

Abstract

The coexistence of autoimmune disorders (AD) in patients with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) has been widely recognized, although with distinct results regarding their prevalence and impact on the outcomes of the underlying hematological process. This study was aimed to analyze the prevalence, clinical characteristics, and outcomes of MDS with AD in a series of 142 patients diagnosed with MDS and CMML. AD was ascertained by both the presence of clinical symptoms or compatible serological tests. In total, 48% patients were diagnosed as having AD, being hypothyroidism the most commonly reported clinical AD (8%) and antinuclear antibodies the most frequent serological parameter identified (23.2%). The presence of AD was associated with female gender, lower hemoglobin levels, and higher IPSS-R. Overall survival for patients with AD was inferior to those with no AD (69 vs. 88% at 30 months; HR 2.75, P = 0.008). Notably, clinical but not isolated immune serological parameters had an impact on the outcomes of patients with AD. Finally, in a multivariate analysis, the presence of AD (HR 2.26) along with disease risk categories (very low and low vs. intermediate, high, and very high IPSS-R; HR 4.62) retained their independent prognostic value (P < 0.001). In conclusion, AD are prevalent in MDS and CMML patients and have prognostic implications, especially in lower-risk MDS patients.

https://ift.tt/2tAJ3kC

Light chain monoclonal gammopathy of undetermined significance is characterized by a high disappearance rate and low risk of progression on longitudinal analysis

Abstract

We determined the 10-year progression rate of light chain monoclonal gammopathy of undetermined significance (LCMGUS) and investigated potential associations with cancer utilizing the German population-based Heinz Nixdorf Recall Study. The Heinz Nixdorf Recall Study comprises 4814 men and women aged 45–75 years. Serum samples from baseline (2000–2003) and five-year (2006–2008) and 10-year (2011–2015) follow-up examinations were screened for monoclonal free light chains (FLC). LCMGUS was defined as abnormal FLC ratio, increase of involved FLC with complete loss of immunoglobulin heavy chain, and absence of a history of lymphoproliferative disease (LPD). Seventy-five individuals with LCMGUS were identified across all three evaluation time points (median age 64 years; 43 (57%) male; FLCR > 1.65 65 (87%); FLCR ≤ 0.65 10 (13%)). After a median observation time of 11.5 years, none of the LCMGUS cases had progressed to overt LPD; in particular, we did not observe incident light chain multiple myeloma. On serial analysis 17/31 (55%), LCMGUS could not be confirmed and disappearance of the monoclonal protein was associated with low concentrations of the involved FLC. Individuals with LCMGUS had a 1.5-fold increased risk of cancer but did not show differences in overall survival or renal function as compared to individuals with normal FLC. In conclusion, LCMGUS represents a relatively benign condition with a high disappearance rate of the monoclonal protein on longitudinal analysis and normal overall survival at least in the population-based setting.

https://ift.tt/2lv6rMF

Diffuse large B cell lymphoma (DLBCL): bilateral vanishing tibiae

https://ift.tt/2txjq48

Outcomes of patients with myelofibrosis treated with compassionate use pacritinib: a sponsor-independent international study

Abstract

Myelofibrosis (MF) is a chronic yet progressive myeloid neoplasm in which only a minority of patients undergo curative therapy, hematopoietic stem cell transplantation. Ruxolitinib, a JAK1/2 inhibitor, is the lone therapy approved for MF, offering a clear symptom and spleen benefit at the expense of treatment-related cytopenias. Pacritinib (PAC), a multi-kinase inhibitor with specificity for JAK2, FLT3, and IRAK1 but sparing JAK1, has demonstrated clinical activity in MF with minimal myelosuppression. Due to an FDA-mandated full clinical hold, the randomized phase 3 PERSIST trials were abruptly stopped and PAC was immediately discontinued for all patients. Thirty-three patients benefitting from PAC on clinical trial prior to the hold were allowed to resume therapy on an individual, compassionate-use basis. This study reports the detailed outcomes of 19 of these PAC retreatment patients with a median follow-up of 8 months. Despite a median platelet count of 49 × 10⁹/L at restart of PAC, no significant change in hematologic profile was observed. Grade 3/4 adverse events of epistaxis (n = 1), asymptomatic QT prolongation (n = 1), and bradycardia (n = 1) occurred in three patients within the first 3 months of retreatment. One death due to catheter-associated sepsis occurred. The median time to discontinuation of PAC therapy on compassionate use for all 33 patients was 12.2 (95% CI 8.3—NR) months. PAC retreatment was associated with modest improvement in splenomegaly without progressive myelosuppression and supports the continued development of this agent for the treatment of MF second line to ruxolitinib or in the setting of treatment-limiting thrombocytopenia.

https://ift.tt/2lxUDJq

Isolated Richter’s syndrome of the brain: diagnosis in the eye of the beholder

https://ift.tt/2yKOkf0

Eltrombopag as initial monotherapy for severe aplastic anemia—a case report

https://ift.tt/2lyNadm

Brentuximab vedotin is effective for rheumatoid arthritis in a patient with relapsed methotrexate-associated Hodgkin lymphoma

https://ift.tt/2tzbi33

Clinical impact of underweight status at diagnosis on elderly patients with acute myeloid leukemia: a retrospective study of JALSG GML200

https://ift.tt/2lvpJS1

Sleep Apnea Is a Risk Factor for Stroke and Vascular Dementia

Abstract

Purpose of Review

In this article, we review the cerebrovascular complications of sleep apnea (SA). SA is the major sleep disorder associated with stroke and vascular dementia.

Recent Findings

Sleep apnea syndrome of moderate to severe intensity affects 17% of 50–70-year-old men and 9% of 50–70-year-old women, making SA a notorious and prevalent disorder. SA increases the risk of hypertension, stroke, myocardial infarction, and atrial fibrillation (AF) and is closely linked to vascular dementia. In addition, SA may worsen the neurologic outcome in acute stroke patients and interferes with rehabilitation after stroke.

Summary

Proper management of SA may decrease the clinical impact of stroke risk factors, improve neurologic outcome after stroke, and lessen the progression of subcortical ischemic vascular disease. In this article, we will cover the most salient pathologies that associate SA and cerebrovascular pathology.

https://ift.tt/2tp9avk

Naloxone is becoming more available in airline medical kits [Letters]

https://ift.tt/2K66g9x

Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis [Correction]

https://ift.tt/2K66a1F

Euglycemic diabetic ketoacidosis associated with the use of a sodium-glucose cotransporter-2 inhibitor [Practice]

https://ift.tt/2KkIKkW

Adnexal torsion [Practice]

https://ift.tt/2Ilf8lP

Residency programs grapple with new Indigenous cultural safety training requirement [News]

https://ift.tt/2K67C42

Poems about Alzheimer disease [Humanities]

https://ift.tt/2IomvZE

The evolving epidemiology of Clostridium difficile infection in Canadian hospitals during a postepidemic period (2009-2015) [Research]

Background:

The clinical and molecular epidemiology of health care–associated Clostridium difficile infection in nonepidemic settings across Canada has evolved since the first report of the virulent North American pulsed-field gel electrophoresis type 1 (NAP1) strain more than 15 years ago. The objective of this national, multicentre study was to describe the evolving epidemiology and molecular characteristics of health care–associated C. difficile infection in Canada during a post-NAP1-epidemic period, particularly patient outcomes associated with the NAP1 strain.

Methods:

Adult inpatients with C. difficile infection were prospectively identified, using a standard definition, between 2009 and 2015 through the Canadian Nosocomial Infection Surveillance Program (CNISP), a network of 64 acute care hospitals. Patient demographic characteristics, severity of infection and outcomes were reviewed. Molecular testing was performed on isolates, and strain types were analyzed against outcomes and epidemiologic trends.

Results:

Over a 7-year period, 20 623 adult patients admitted to hospital with health care–associated C. difficile infection were reported to CNISP, and microbiological data were available for 2690 patients. From 2009 to 2015, the national rate of health care–associated C. difficile infection decreased from 5.9 to 4.3 per 10 000 patient-days. NAP1 remained the dominant strain type, but infection with this strain has significantly decreased over time, followed by an increasing trend of infection with NAP4 and NAP11 strains. The NAP1 strain was significantly associated with a higher rate of death attributable to C. difficile infection compared with non-NAP1 strains (odds ratio 1.91, 95% confidence interval [CI] 1.29–2.82). Isolates were universally susceptible to metronidazole; one was nonsusceptible to vancomycin. The proportion of NAP1 strains within individual centres predicted their rates of health care–associated C. difficile infection; for every 10% increase in the proportion of NAP1 strains, the rate of health care–associated C. difficile infection increased by 3.3% (95% CI 1.7%–4.9%).

Interpretation:

Rates of health care–associated C. difficile infection have decreased across Canada. In nonepidemic settings, NAP4 has emerged as a common strain type, but NAP1, although decreasing, continues to be the predominant circulating strain and remains significantly associated with higher attributable mortality.

https://ift.tt/2KnK8qa

In defense of Canadas drug plan managers [Letters]

https://ift.tt/2Klzzkx

Many doctors feel "betrayed" by sale of MD Financial Management [News]

https://ift.tt/2Ki27OY

Suggestions for managing in-flight emergencies [Letters]

https://ift.tt/2KhOYCi

Dr. Jack Tu, a research superstar ahead of his time (1965-2018) [News]

https://ift.tt/2K828pq

Add naloxone to in-flight medical supplies [Letters]

https://ift.tt/2IpJa7L

No use for this foot [Coda]

https://ift.tt/2K4lYSg

Ovarian stimulation for IVF and risk of primary breast cancer in BRCA1/2 mutation carriers

Ovarian stimulation for IVF and risk of primary breast cancer in BRCA1/2 mutation carriers

Ovarian stimulation for IVF and risk of primary breast cancer in <i>BRCA1/2</i> mutation carriers, Published online: 25 June 2018; doi:10.1038/s41416-018-0139-1

Ovarian stimulation for IVF and risk of primary breast cancer in BRCA1/2 mutation carriers

https://ift.tt/2txhObB

Interaction of WBP2 with ERα increases doxorubicin resistance of breast cancer cells by modulating MDR1 transcription

Interaction of WBP2 with ERα increases doxorubicin resistance of breast cancer cells by modulating MDR1 transcription

Interaction of WBP2 with ERα increases doxorubicin resistance of breast cancer cells by modulating <i>MDR1</i> transcription, Published online: 25 June 2018; doi:10.1038/s41416-018-0119-5

Interaction of WBP2 with ERα increases doxorubicin resistance of breast cancer cells by modulating MDR1 transcription

https://ift.tt/2K2HarQ

Efficacy of Spa Therapy, Mud-Pack Therapy, Balneotherapy, and Mud-Bath Therapy in the Management of Knee Osteoarthritis. A Systematic Review

Background. Osteoarthritis (OA) is the most common musculoskeletal disease in the world. OA is the result of an inflammatory and degenerative process affecting the entire joint. Osteoarthritis, especially involving the knee, has a relevant socioeconomic impact in terms of drugs, hospital admissions, work absences, and temporary or permanent invalidity. Therapy of knee osteoarthritis is based on pharmacological and nonpharmacological measures. Methods. We conducted a systematic review of the studies published between 2002 and 2017 on spa therapy, mud-pack therapy, balneotherapy, and mud-bath therapy in the treatment of knee osteoarthritis in order to investigate the evidence of the efficacy of such treatment on pain, functional limitation, drug use, and quality of life. Overall, 35 studies were examined among which 12 were selected and included in the review if they are trial comparative. We have been able to illustrate the main results obtained in the individual studies and to elaborate these results in order to allow as much a unitary presentation as possible and hence an overall judgment. Results. Because the studies we reviewed differed markedly from one another in terms of the methods used, we were unable to conduct a quantitative analysis (meta-analysis) of pooled data from the 12 studies. For the purposes of the present review, we reevaluated the results of the different studies using the same statistical method, Student's t-test, which is used to compare the means of two frequency distributions. Among all the studies, the most relevant indexes used to measure effectiveness of spa therapy were improved including VAS, Lequesne, and WOMAC Score. Conclusions. The mud-pack therapy, balneotherapy, mud-bath therapy, and spa therapy have proved to be effective in the treatment and in the secondary prevention of knee osteoarthritis, by reducing pain, nonsteroidal anti-inflammatory drug consumption, and functional limitation and improving quality of life of affected patients.

https://ift.tt/2Kgx9Xv

C-Kit Cardiac Progenitor Cell Based Cell Sheet Improves Vascularization and Attenuates Cardiac Remodeling following Myocardial Infarction in Rats

The adult heart contains small populations of multipotent cardiac progenitor cells (CPC) that present a convenient and efficient resource for treatment of myocardial infarction. Several clinical studies of direct CPC delivery by injection have already been performed but showed low engraftment rate that limited beneficial effects of procedure. «Cell sheet» technology has been developed to facilitate longer retention of grafted cells and show new directions for cell-based therapy using this strategy. In this study we hypothesized that СPC-based cell sheet transplantation could improve regeneration after myocardial infarction. We demonstrated that c-kit+ CPC were able to form cell sheets on temperature-responsive surfaces. Cell sheet represented a well-organized structure, in which CPC survived, retained ability to proliferate, expressed progenitor cell marker Gata-4 formed connexin-43+ gap junctions, and were surrounded by significant amount of extracellular matrix proteins. Transplantation of cell sheets after myocardial infarction resulted in CPC engraftment as well as their proliferation, migration, and differentiation; cell sheets also stimulated neovascularization and cardiomyocyte proliferation in underlining myocardium and ameliorated left ventricular remodeling. Obtained data strongly supported potential use of CPC sheet transplantation for repair of damaged heart.

https://ift.tt/2Innw4i

Association of Visual Defects and Occlusal Molar Class in Children

Purpose. The purpose of this cross-sectional study is to evaluate the presence of any correlations between dysfunctions related to visual impairments and dental occlusion. Methods. The test group included 34 subjects (21 males and 13 females; mean age 11 ± 2 years) randomly selected with the following inclusion criteria: absence of any diagnosis for problems at visual level except those related to refractive defects, visual acuity of at least 1.0, absence of any syndrome or malformation in the craniofacial area, good general health, and absence of any systemic disease able to influence the vision or the craniofacial growth. They underwent visual clinical tests to evaluate the presence of fusional vergence defects and amplitude. Each patient underwent an orthodontic clinical exam and the occlusal molar relationship of each subject was recorded and considered as occlusal variable. A statistical analysis with Chi-Squared test was performed in order to analyze the associations between the visual defects and the occlusal variable. Results. A statistically significant association between the molar occlusal relationship and the occurrence of exodeviations was observed. The percentage of subjects presenting fusional amplitudes with convergence lower of the cut-off value was statistically significantly higher in the group of occlusal molar second class. Conclusions. The results obtained show that there is an association between occlusal second molar class and fusional vergence defects.

https://ift.tt/2KkhZ3e

Infection of a Ventricular Septal Defect Patch with Acremonium Species

A ventricular septal defect (VSD) patch infection with Acremonium species isolated from vegetation and blood culture is described. Antifungal treatment was discontinued after 3 months and patient developed relapse. Surgery with prolonged oral voriconazole was instituted with recovery. We emphasize importance of surgery and prolonged therapy to treat such infections.

https://ift.tt/2MmNfw9

Ovarian stimulation for IVF and risk of primary breast cancer in BRCA1/2 mutation carriers

https://ift.tt/2tAwplF

Interaction of WBP2 with ERα increases doxorubicin resistance of breast cancer cells by modulating MDR1 transcription

https://ift.tt/2tBd1os

Child and maternal attachment predict school‐aged children’s psychobiological convergence

Developmental Psychobiology, EarlyView.


https://ift.tt/2ttN5Lw

Maternal report of infant negative affect predicts attenuated brain response to own infant

Developmental Psychobiology, EarlyView.


https://ift.tt/2MTQnkc

Predictors of social instability stress effects on social interaction and anxiety in adolescent male rats

Developmental Psychobiology, EarlyView.


https://ift.tt/2tysGoM

Children’s autonomic functioning moderates links between maternal rejecting attitudes and preschool aggressive behaviors

Developmental Psychobiology, EarlyView.


https://ift.tt/2MTQlJ6

Hakkotsu Zazen zu

Clinical Anatomy, Volume 31, Issue 5, Page 615-615, July 2018.


https://ift.tt/2In4ivE

“Osler Warned”: Was William Osler a Grave Robber While at McGill or Was He a Victim (or Perpetrator) of One Final Practical Joke?

Clinical Anatomy, Volume 31, Issue 5, Page 632-640, July 2018.


https://ift.tt/2Khv6m0

Issue Information

Clinical Anatomy, Volume 31, Issue 5, Page C1-C1, July 2018.


https://ift.tt/2MgJgB9

Immunohistochemical and genetic characteristics of a colorectal mucin‐rich variant of traditional serrated adenoma

Histopathology, EarlyView.


https://ift.tt/2K50CnW

Peritumoral granulomatous reaction in endometrial carcinoma: association with DNA mismatch repair protein deficiency, particularly loss of PMS2 expression

Histopathology, EarlyView.


https://ift.tt/2MmCbPv

BRAFV600E mutations and immunohistochemical expression of VE1 protein in low‐grade serous neoplasms of the ovary

Histopathology, EarlyView.


https://ift.tt/2K50tAU

Eosinophilic oesophagitis: relevance of mast cell infiltration

Histopathology, EarlyView.


https://ift.tt/2MkwGB3

Breast cancer metastatic to the liver with hepatoid features and hepatocyte paraffin 1 positivity mimicking hepatocellular carcinoma

Histopathology, EarlyView.


https://ift.tt/2K50m8s

Potassium octatitanate fibers induce persistent lung and pleural injury and are possibly carcinogenic in male Fischer 344 rats

Cancer Science, EarlyView.


https://ift.tt/2K5ZErH

Mixed-phenotype large granular lymphocytic leukemia (LGLL): a rare subtype in the LGLL Spectrum

Large granular lymphocytic leukemia (LGLL) is a chronic proliferation of cytotoxic lymphocytes in which over 70% of patients develop cytopenia(s) requiring therapy. LGLL includes T-cell LGLL (T-LGLL) and chronic lymphoproliferative disorder of NK-cells (CLPD-NK). The neoplastic cells in LGLL usually exhibit a single immunophenotype in a patient, with CD8-positive/αβ T-cell type being the most common, followed by NK-cell, γδ T-cell, and CD4-positive/αβ T-cell types. We investigated a total of 220 LGLL cases and identified 12 mixed-phenotype LGLLs (5%): 7 cases with coexistent αβ T-cell and NK-cell clones and 5 with coexistent αβ and γδ T-cell clones.

https://ift.tt/2tqXuIM

Fluorescence in situ hybridization for the diagnosis of NPHP1 deletion-related nephronophthisis on renal biopsy

Nephronophthisis is an autosomal recessive tubulointerstitial nephropathy that is a leading genetic etiology of end stage renal disease in children and young adults. Approximately 60% of patients with a known genetic etiology of nephronophthisis are due to homozygous deletion of the NPHP1 gene. We identified a total of 45 renal biopsies from young patients with chronic kidney disease of undetermined etiology and analyzed them for the possibility of nephronophthisis due to NPHP1 deletion using interphase fluorescence in situ hybridization and/or polymerase chain reaction.

https://ift.tt/2yAECfn

Microglandular adenosis of the breast: a deceptive and still misterious benign lesion

Microglandular adenosis of the breast (MA), a benign glandular proliferation, was originally described about 35years ago. The lesion, is constituted by small glands all of the same size. Glands are lined by one layer of cuboidal epithelial cells encircled by basal lamina without any evidence of interposed myoepithelial elements. Cells are positive for low weight keratins and S-100 protein and negative for ER, PR and HER 2. Since then, in the years, several malignant lesions all showing microglandular architecture have been regarded either as a precursor or an equivalent manifestation of MA.

https://ift.tt/2tqXnNm

Genomic structures of dysplastic nodule and concurrent hepatocellular carcinoma

Although high-grade dysplastic nodule (HGDN) is a preneoplastic lesion that precedes hepatocellular carcinoma (HCC), the genomic structures of HGDN in conjunction with HCC remain elusive. The objective of this study was to identify genomic alterations of HGDN and its difference from HCC that may drive HGDN progression to HCC. We analyzed 16 regions of paired HGDN and HCC from 6 patients using whole-exome sequencing to find somatic mutation and copy number alteration (CNA) profiles of HGDN and HCC.

https://ift.tt/2yD5sDz

ARHGAP42 promotes cell migration and invasion involving PI3K/Akt signaling pathway in nasopharyngeal carcinoma

Cancer Medicine, EarlyView.


https://ift.tt/2ImYgeu

Surgically resected T1‐ and T2‐stage esophageal squamous cell carcinoma: T and N staging performance of EUS and PET/CT

Cancer Medicine, EarlyView.


https://ift.tt/2K6ch5N

Safety and efficacy of combination therapy of interferon‐α2 and ruxolitinib in polycythemia vera and myelofibrosis

Cancer Medicine, EarlyView.


https://ift.tt/2KkTwYn

Trends in colorectal cancer incidence among younger adults—Disparities by age, sex, race, ethnicity, and subsite

Cancer Medicine, EarlyView.


https://ift.tt/2KijA9S

Lateral alveolar ridge augmentation with autogenous block grafts fixed at a distance versus resorbable Poly‐D‐L‐Lactide foil fixed at a distance: A single‐blind, randomized, controlled trial

Clinical Oral Implants Research, EarlyView.


https://ift.tt/2ImFAvr

Evaluation of implant esthetics using eight objective indices—Comparative analysis of reliability and validity

Clinical Oral Implants Research, EarlyView.


https://ift.tt/2Kft05X

Comment on ‘Measuring the impact of medicines regulatory interventions – systematic review and methodological considerations’ by Goedecke et al.

British Journal of Clinical Pharmacology, EarlyView.


https://ift.tt/2tyBYAV

Patient selection and timing of allogeneic hematopoietic stem cell transplantation for relapsed follicular lymphoma

CA: A Cancer Journal for Clinicians, EarlyView.


https://ift.tt/2MmxDZr

BioEssays 7∕2018

BioEssays, Volume 40, Issue 7, July 2018.


https://ift.tt/2Kigak8

BioEssays 7∕2018

BioEssays, Volume 40, Issue 7, July 2018.


https://ift.tt/2K3FqP2

BioEssays 7∕2018

BioEssays, Volume 40, Issue 7, July 2018.


https://ift.tt/2Kie9Vl

Constitutive plasma membrane monoamine transporter (PMAT, Slc29a4) deficiency subtly affects anxiety‐like and coping behaviours

European Journal of Neuroscience, EarlyView.


https://ift.tt/2Mmp4hn

α‐Synuclein activates innate immunity but suppresses interferon‐γ expression in murine astrocytes

European Journal of Neuroscience, EarlyView.


https://ift.tt/2tpY1L3

Social defeat stress induces hyperalgesia and increases truncated BDNF isoforms in the nucleus accumbens regardless of the depressive‐like behavior induction in mice

European Journal of Neuroscience, EarlyView.


https://ift.tt/2MmhYZY

Fe–Au Nanoparticle‐Coupling for Ultrasensitive Detections of Circulating Tumor DNA

Advanced Materials, EarlyView.


https://ift.tt/2yG9NpC

Under Diffusion Control: from Structuring Matter to Directional Motion

Advanced Materials, EarlyView.


https://ift.tt/2lv1Bir

Solution Mask Liquid Lithography (SMaLL) for One‐Step, Multimaterial 3D Printing

Advanced Materials, EarlyView.


https://ift.tt/2yAu3sJ

Investigation of the Prussian Blue Analog Co3[Co(CN)6]2 as an Anode Material for Nonaqueous Potassium‐Ion Batteries

Advanced Materials, EarlyView.


https://ift.tt/2lvbM6I

DNA Nanoelectronics: Highly Conductive Thin Uniform Gold‐Coated DNA Nanowires (Adv. Mater. 26/2018)

Advanced Materials, Volume 30, Issue 26, June 27, 2018.


https://ift.tt/2yG9ICk

Paper Electronics: Laser‐Induced Molybdenum Carbide–Graphene Composites for 3D Foldable Paper Electronics (Adv. Mater. 26/2018)

Advanced Materials, Volume 30, Issue 26, June 27, 2018.


https://ift.tt/2MkoKiV

Contents: (Adv. Mater. 26/2018)

Advanced Materials, Volume 30, Issue 26, June 27, 2018.


https://ift.tt/2MTWWTR

Masthead: (Adv. Mater. 26/2018)

Advanced Materials, Volume 30, Issue 26, June 27, 2018.


https://ift.tt/2MkoD6Z

Adaptive Materials: Light‐Driven Reversible Transformation between Self‐Organized Simple Cubic Lattice and Helical Superstructure Enabled by a Molecular Switch Functionalized Nanocage (Adv. Mater. 26/2018)

Advanced Materials, Volume 30, Issue 26, June 27, 2018.


https://ift.tt/2MkoAbj

Electrocatalytic Nanomaterials: Atomic‐Scale Core/Shell Structure Engineering Induces Precise Tensile Strain to Boost Hydrogen Evolution Catalysis (Adv. Mater. 26/2018)

Advanced Materials, Volume 30, Issue 26, June 27, 2018.


https://ift.tt/2MRIxaG

Organic Batteries: An Ultrahigh Output Rechargeable Electrode of a Hydrophilic Radical Polymer/Nanocarbon Hybrid with an Exceptionally Large Current Density beyond 1 A cm−2 (Adv. Mater. 26/2018)

Advanced Materials, Volume 30, Issue 26, June 27, 2018.


https://ift.tt/2MkoqRf

Photochromic Materials: 3D‐Printable Photochromic Molecular Materials for Reversible Information Storage (Adv. Mater. 26/2018)

Advanced Materials, Volume 30, Issue 26, June 27, 2018.


https://ift.tt/2MTBJJH

Transparent Electrodes: Reverse‐Offset Printed Ultrathin Ag Mesh for Robust Conformal Transparent Electrodes for High‐Performance Organic Photovoltaics (Adv. Mater. 26/2018)

Advanced Materials, Volume 30, Issue 26, June 27, 2018.


https://ift.tt/2MgCWtp

Field‐Free Programmable Spin Logics via Chirality‐Reversible Spin–Orbit Torque Switching

Advanced Materials, EarlyView.


https://ift.tt/2lvRaer

Thin Film Tin Selenide (SnSe) Thermoelectric Generators Exhibiting Ultralow Thermal Conductivity

Advanced Materials, EarlyView.


https://ift.tt/2MXxfBA

Corrigendum

Experimental Dermatology, Volume 27, Issue 6, Page 697-697, June 2018.


https://ift.tt/2MTzrtS

A Case of an embedded clip in the gastric wall after shielding a post‐endoscopic submucosal dissection ulcer with polyglycolic acid sheet

Digestive Endoscopy, EarlyView.


https://ift.tt/2MmlKTr

NDRG1 and FOXO1 regulate endothelial cell proliferation in infantile haemangioma

Experimental Dermatology, Volume 27, Issue 6, Page 690-693, June 2018.


https://ift.tt/2tAiImL

No evidence for follicular keratinocyte hyperproliferation in acne lesions as compared to autologous healthy hair follicles

Experimental Dermatology, Volume 27, Issue 6, Page 668-671, June 2018.


https://ift.tt/2yAwdIR

A guide to studying human dermal adipocytes in situ

Experimental Dermatology, Volume 27, Issue 6, Page 589-602, June 2018.


https://ift.tt/2tt8HIE

Clinical Snippets

Experimental Dermatology, Volume 27, Issue 6, Page i-i, June 2018.


https://ift.tt/2yAw7kt

Issue Information

Experimental Dermatology, Volume 27, Issue 6, Page 587-588, June 2018.


https://ift.tt/2tqao9Z

Methadone—Not a magic bullet in melanoma therapy

Experimental Dermatology, Volume 27, Issue 6, Page 694-696, June 2018.


https://ift.tt/2yDRGAN

Digital analysis yields more reliable and accurate measures of dermal and epidermal thickness in histologically processed specimens compared to traditional methods

Experimental Dermatology, Volume 27, Issue 6, Page 687-690, June 2018.


https://ift.tt/2tt8oxu

CSF3R mutations are frequently associated with abnormalities of RUNX1, CBFB, CEBPA, and NPM1 genes in acute myeloid leukemia

Cancer, EarlyView.


https://ift.tt/2Ikempb

A home‐based mentored vegetable gardening intervention demonstrates feasibility and improvements in physical activity and performance among breast cancer survivors

Cancer, EarlyView.


https://ift.tt/2K536me

Evaluation of 2 breast cancer risk models in a benign breast disease cohort

Cancer, EarlyView.


https://ift.tt/2ImUUIr

Inference in the Wild: A Framework for Human Situation Assessment and a Case Study of Air Combat

Cognitive Science, EarlyView.


https://ift.tt/2yFM6xK

Infantile Hemangioma Presenting as Colocolic Intussusception in an Infant Case Report with Review of Pathologic Lead Points

Infantile hemangioma (IH) is one of the most common vascular anomalies of early childhood and is usually recognized in the first few weeks to months of life as a solitary cutaneous lesion. This report documents our experience with a GLUT-1 positive IH presenting as the pathologic lead point in a colocolic intussusception in a 10-week-old infant who had no skin lesions. Literature suggests approximately 2% of all children presenting with an intussusception require surgical intervention; however, an IH as the pathologic lead point is unique.

https://ift.tt/2ImhYa8

Bougainvillea Genus: A Review on Phytochemistry, Pharmacology, and Toxicology

This review discusses the current knowledge of the phytochemistry and in vitro and in vivo evaluations carried out using the extracts and, where appropriate, the main active components isolated from the genus Bougainvillea. Out of 18 species, most phytochemical, pharmacological, and toxicological studies focused on four species with different cultivars and one hybrid. Some plants are used for the treatment of various health disorders. Numerous phytochemical investigations of plants in this genus confirm the presence of aliphatic hydrocarbons, fatty acids, fatty alcohols, volatile compounds, phenolic compounds, peltogynoids, flavonoids, phytosterols, terpenes, carbohydrates, and betalains. Various studies have confirmed that these extracts or active substances that were isolated from the genus Bougainvillea have multiple pharmacological activities. Some species of Bougainvillea have emerged as sources of traditional medicine in human health. More studies of the phytochemical, pharmacological, and toxicological properties and their mechanisms of action, safety, and efficacy in all Bougainvillea species, cultivars, and hybrids are advisable for future research.

https://ift.tt/2Io3Ay7

A Global Call to Action to improve the care of people with fragility fractures

Publication date: Available online 23 June 2018
Source:Injury
Author(s): KE Dreinhöfer, PJ Mitchell, T Bégué, C Cooper, ML Costa, P Falaschi, K Hertz, D Marsh, S Maggi, A Nana, H Palm, R Speerin
The ageing of society is driving an enormous increase in fragility fracture incidence and imposing a massive burden on patients, their families, health systems and societies globally. Disrupting the status quo has therefore become an obligation and a necessity.Initiated by the Fragility Fracture Network (FFN) at a "Presidents Roundtable" during the 5^th FFN Global Congress in 2016 several leading organisations agreed that a global multidisciplinary and multiprofessional collaboration, resulting in a Global Call to Action (CtA), would be the right step forward to improve the care of people presenting with fragility fractures. So far global and regional organisations in geriatrics/internal medicine, orthopaedics, osteoporosis/metabolic bone disease, rehabilitation and rheumatology were contacted as well as national organisations in five highly populated countries (Brazil, China, India, Japan and the United States), resulting in more than 75 societies endorsing the CtA so far.We call for implementation of a systematic approach to fragility fracture care with the goal of restoring function and preventing subsequent fractures without further delay.There is an urgent need to improve:• Acute multidisciplinary care for the person who suffers a hip, clinical vertebral and other major fragility fractures• Rapid secondary prevention after first occurrence of all fragility fractures, including those in younger people as well as those in older persons, to prevent future fractures• Ongoing post-acute care of people whose ability to function is impaired by hip and major fragility fracturesTo address this fragility fracture crisis, the undersigned organisations pledge to intensify their efforts to improve the current management of all fragility fractures, prevent subsequent fractures, and strive to restore functional abilities and quality of life.



https://ift.tt/2Im31F5

Erratum to “Severe Drug-Induced Agranulocytosis Successfully Treated with Recombinant Human Granulocyte Colony-Stimulating Factor”

https://ift.tt/2MlzrSB

Comparison of the Effectiveness of New Material Diapers versus Standard Diapers for the Prevention of Diaper Rash in Chinese Babies: A Double-Blinded, Randomized, Controlled, Cross-Over Study

Background. Diaper rash, also known as diaper dermatitis (DD), is a very common skin condition in infants, and use of disposable diapers with breathable materials is an effective approach for the management of diaper rash. In China, new material diapers and standard diapers are currently the two most commonly used disposable diapers. This study aimed to compare the effectiveness of new material diapers versus standard diaper for the prevention of diaper rash in Chinese babies. Methods. A total of 80 eligible babies admitted to Shanghai Skin Diseases Hospital during the period from June through July, 2016, were enrolled and randomized into two groups. Babies in Group A () used the new material diapers, and babies in Group B () used standard diapers. Two weeks after the use of the diaper, the babies used the alternate product for the next 2 weeks. Skin conditions were assessed on the front and back waist, right and left buttock, pubic region, anal region, and right and left groin using a 6-point scoring system based on four parameters in 0, 2, and 4 weeks after use of the diapers. Results. There were changes of the mean skin assessment score in each of the six regions after the use of the diapers. There were significant differences, in the mean skin assessment score of the front waist in Group A between weeks 2 and 4 () and in Group B between weeks 0 and 2 (), and no significant differences were detected in the mean skin assessment score of the back waist and buttock in both Group A and Group B on weeks 0, 2, and 4. A higher mean skin assessment score of the pubic region was assessed in Group A on week 4 than on week 2 (), with a higher score seen on week 2 than on week 0 (), while no significant differences were found in Group B among weeks 0, 2, or 4. There was a higher mean score of the anal region assessed in Group A on week 2 than on week 0 (), while a higher mean score was found in Group B on week 2 than on weeks 0 () and 4 (). In addition, a higher mean skin assessment score of the groin was detected on week 2 than on week 0 in both Group A () and Group B (). Conclusion. The new material diaper is superior to the standard diaper for the prevention of diaper rash in Chinese babies.

https://ift.tt/2K7V5Nl

Find the Essence through the Phenomena: Cardiovascular Diseases and Biomarkers

https://ift.tt/2KglckG

Informational interventions on paternal outcomes during the perinatal period: A systematic review

Publication date: Available online 23 June 2018
Source:Women and Birth
Author(s): Shefaly Shorey, Lina Ang, Wilson W.S. Tam
ProblemThe perinatal period is a stressful transition for new parents.BackgroundVarious forms of educational interventions are available and are found to be efficacious in improving maternal and child outcomes. Such interventions for fathers were scarce and western-centric. Fathers should be educated as they have an impact on maternal and child outcomes.AimThis review aims to evaluate the efficacy of quantitatively-studied informational support-focused interventions for fathers using paternal outcomes only.MethodsThe search was carried out in six databases: Cumulative Index to Nursing and Allied Health Literature, PubMed, Scopus, Embase, Psychological Information Database, and MedNar. Cochrane Collaboration's tools were used to assess the eligibility of the studies.FindingsA total of 17 studies with 18 interventions were identified and included in the narrative synthesis. Most interventions were delivered to the Western population during the antenatal or postpartum period. The method of delivery for these interventions was mainly face-to-face, with inconclusive findings on various paternal psychosocial outcomes.DiscussionLimited father-inclusive interventions were available. Technology-based longitudinal studies with interventions carried out across the perinatal period with longer follow-up periods were recommended for interventions providing informational support for fathers. Future studies can also examine paternal physical health and behavioural outcomes. Interventions in culturally-diverse populations should be designed and tested for their efficacies as fathers have different informational needs, especially in Asia.ConclusionInformational interventions for fathers were found to be lacking and recommendations for future studies on educational interventions for fathers were discussed.



https://ift.tt/2tmVy3I

Asking different questions: A call to action for research to improve the quality of care for every woman, every child

Publication date: Available online 23 June 2018
Source:Women and Birth
Author(s): H.P. Kennedy, M. Cheyney, H.G. Dahlen, S. Downe, M.J. Foureur, C.S.E. Homer, E. Jefford, A. McFadden, M. Michel-Schuldt, J. Sandall, H. Soltani, A.M. Speciale, J. Sevens, S. Vedam, M.J. Renfrew




https://ift.tt/2yIR2lc

A Case of Sirenomelia Associated with Hypoplastic Left Heart with a Healthy Co-Twin: A Rare Entity

Sirenomelia is a rare developmental malformation and is incompatible to life. The incidence of sirenomelia, as recorded in the literature, is estimated to be approximately between 1.5 and 4.2 per 1,00,000 births. Around 15% of sirenomelia cases are associated with twin pregnancy, most often in monozygotic cases with an incidence of 7%. In monozygotic twins, the risk of sirenomelia is nearly 100–150 times higher as compared to dizygotic twins or singleton pregnancies. Until now, only two cases of sirenomelia associated with hypoplastic left heart have been reported in the literature. Here, we present a monozygotic twin pregnancy, where one fetus was diagnosed with sirenomelia associated with hypoplastic left heart syndrome and the co-twin was absolutely healthy.

https://ift.tt/2K2wYQ4

Successful Treatment of Severe Atopic Dermatitis with Calcitriol and Paricalcitol in an 8-Year-Old Girl

Atopic dermatitis (AD) is a chronic inflammatory disease affecting children and adolescence. The traditional therapeutic options for AD, including emollients topically and immune modulatory agents systemically focusing on reducing skin inflammation and restoring the function of the epidermal barrier, are proven ineffective in many cases. Several studies have linked vitamin D supplementation with either a decreased risk to develop AD or a clinical improvement of the symptoms of AD patients. In this report, we present a girl with severe AD who under adequate supplementation with cholecalciferol was treated with calcitriol and subsequently with paricalcitol. She had significant improvement—almost healing of her skin lesions within 2 months, a result sustained for more than 3 years now. Because of hypercalciuria as a side effect from calcitriol therapy, treatment was continued with paricalcitol, a vitamin D analogue used in secondary hyperparathyroidism in chronic kidney disease. Calcitriol therapy may be considered as a safe and efficacious treatment option for patients with severe AD, particularly for those with refractory AD, under monitoring for possible side effects. Treatment with paricalcitol resolves hypercalciuria, is safe, and should be further investigated as an alternative treatment of atopic dermatitis and possibly other diseases of autoimmune origin.

https://ift.tt/2ImoU7k

X-Linked Chronic Granulomatous Disease: Initial Presentation with Intracranial Hemorrhage from Vitamin K Deficiency in Infant

Vitamin K deficiency bleeding (VKDB) is a life-threatening condition and can be found in children as early as neonatal period with early onset intracranial hemorrhage (ICH). Here, we reported a 1-year-old boy who initially presented with intracranial hemorrhage secondary to vitamin K deficiency since 3 months of age and later found to have XL-CGD which was complicated by malabsorption due to severe vaccine-associated mycobacterial disease.

https://ift.tt/2K6tqwn

Phytochemical Screening and Antidiabetic, Antihyperlipidemic, and Antioxidant Properties of Anthyllis henoniana (Coss.) Flowers Extracts in an Alloxan-Induced Rats Model of Diabetes

Background. This study investigates the biological activities of Anthyllis henoniana flowers extracts. Materials and Methods. Antioxidant activity and the in vitro inhibitory effect of key digesting enzymes related to postprandial hyperglycemia were determined. Diabetic rats were orally and daily given the best extract from flowers of Anthyllis henoniana at a dose of acarbose for one month. Results. Among the extracts, the ethyl acetate one displayed remarkable antioxidant activity including DPPH (IC50 = 2.34 mg/mL) and was more effective in inhibiting α-glucosidase (IC50 = 17 μg/mL) than α-amylase (IC50 = 920 μg /mL) activities. In vivo, the results proved that ethyl acetate extract at doses of 400 mg/kg bw decreased significantly the blood glucose level and lipid profile levels and increased the activities of antioxidant enzymes. These protective impacts of Anthyllis henoniana ethyl acetate flowers extract were confirmed by histological results. Conclusion. This study demonstrates, for the first time, that Anthyllis henoniana flowers ethyl acetate extract is effective in inhibiting hyperglycemia and oxidative stress caused by diabetes.

https://ift.tt/2K2C9Q9

Paroxysmal Sympathetic Hyperactivity and Clinical Considerations for Patients with Acquired Brain Injuries: A Narrative Review

The term "storming" has often been used colloquially to characterize brain injured patients who showed signs and symptoms of elevated heart rate, blood pressure, respiratory rate, temperature, and motor posturing. Recently, the term paroxysmal sympathetic hyperactivity (PSH) has been used as the unifying term to describe these acute episodes of elevated sympathetic hyperactivity. Various pharmaceutical and management options are available, but no single drug or protocol has been deemed superior to the others. Data on prognosis and recovery in relation to PSH are limited, but point toward poorer functional outcome and increased mortality. Overall, the phenomenon of PSH requires further research to aid rehabilitative efforts so that patients can effectively participate in therapy. A review of the literature has revealed sparse information on the management of sympathetic storming within rehabilitation facilities. This narrative review seeks to provide an up-to-date synopsis and recommendations on the management of rehabilitation inpatients with PSH. Please address all correspondence to: Brian D. Greenwald, MD, Medical Director of Center for Brain Injuries, JFK Medical Center- Johnson Rehabilitation Institute, 65 James Street, Edison, NJ, 08820. Phone: 732-321-7000 ext: 62018. Fax: 732-321-7733. Email: BGreenwald@hackensackmeridian.org There are no disclosures or conflicts of interest reported by the authors. No funding was received by the authors for this work. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2yze9io

Corrigendum to “A Hop Extract Lifenol® Improves Postmenopausal Overweight, Osteoporosis, and Hot Flash in Ovariectomized Rats”

https://ift.tt/2Mi2lmp

Acute Hemolytic Transfusion Reaction in Group B Recipient Associated with Group A Apheresis Platelet Donor: Case Report and Literature Review

Acute hemolytic transfusion reaction is a known but rare potential adverse event related to platelet transfusion. Most reported cases of platelet-related hemolytic transfusion reaction have resulted from transfusion of platelets from group O donor to group A recipient. We identified only one prior case report in the literature of hemolytic transfusion reactions resulting from transfusion of apheresis platelets from group A donor to group B recipient. In that case report, two platelet units were obtained from a single donation and transfused into two separate patients. Both patients exhibited acute hemolytic reactions. The donor is reported to have high anti-B titers, as well as report of probiotic use. We report a case of acute hemolytic reaction in group B recipient following transfusion of apheresis platelets from group A donor with high-titer anti-B but unknown status of probiotic use. This case demonstrates that while low, there still exists potential risk for hemolysis from out-of-group A plasma transfusion.

https://ift.tt/2MUnMv4

An Unusual Case of Gullo’s Syndrome Concomitant with Serious Endometriosis Disease in a Postmenopausal Woman

Gullo's syndrome is a singular physiological phenomenon defined by an abnormal increase in serum pancreatic enzyme levels that may occur in healthy subjects in the absence of pancreatic disorders. During routine health examination in a 54-year-old postmenopausal woman with severe endometriosis, elevated values of serum amylase and lipase were fortuitously observed (198 and 1461 U/L, resp.). Over five years of regular pancreas surveillance, all clinical, biological, and imaging investigations were normal. However, the pancreatic enzyme levels have shown considerable fluctuations including some episodic transient normalization. The description of this benign pancreatic hyperenzymemia case incidentally associated with endometriosis disease is a very rare clinical situation. More in-depth documentation of this phenomenon may help clinicians to avoid unnecessary diagnostic management approaches and reassure the concerned patients that this affection would not be so worrying.

https://ift.tt/2yBTF8q

Corrigendum to “Metabolic Acidosis and Strong Ion Gap in Critically Ill Patients with Acute Kidney Injury”

https://ift.tt/2MW09lA