American Journal of Clinical Oncology - Current IssueCompeting Mortality in Patients With Neuroendocrine Tumors: ErratumNo abstract availableAmerican Journal of Clinical Oncology - Current IssueSat Jan 25, 2020 03:40Sequencing Ipilimumab Immunotherapy Before or After Chemotherapy (Nab-Paclitaxel and Bevacizumab) for the Treatment of BRAFwt (BRAF Wild-Type) Metastatic Malignant Melanoma: Results of a Study of Academic and Community Cancer Research United (ACCRU) RU261206IObjectives: With the introduction...
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Experimental and Clinical Endocrinology & DiabetesPlacental Accumulation of Triacylglycerols in Gestational Diabetes Mellitus and Its Association with Altered Fetal Growth are Related to the Differential Expressions of Proteins of Lipid MetabolismExp Clin Endocrinol DiabetesDOI: 10.1055/a-1017-3182 Introduction Gestational diabetes mellitus (GDM) exhibit altered placental lipid metabolism. The molecular basis of this altered metabolism is not clear. Altered placental expression of proteins of...
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- Featured Articles - Featured ArticlesIntratympanic Diltiazem-Chitosan Hydrogel as an Otoprotectant Against Cisplatin-Induced Ototoxicity in a Mouse ModelHypothesis: Local administration of the calcium-channel blocker (CCB), diltiazem, via intratympanic (IT) chitosan-glycerophosphate (CGP) hydrogel will protect against cisplatin-induced ototoxicity. Background: Cisplatin induces calcium-mediated apoptosis of cochlear outer hair cells (OHCs). Previous work demonstrated otoprotection and reduced...
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Effects of metformin on lipopolysaccharide-induced depressive-like behavior in mice and its mechanisms: Metformin, an AMPK activator, is a widely used medicine for type II diabetes, which has been considered to exert the anti-inflammatory effects. It has been reported that inflammation plays an important role in the pathogenesis of depression. Lipopolysaccharide (LPS) is often utilized to induce depressive-like behavior in mice with respect to recent studies. However, whether metformin alleviates...
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Surgical neurology internationalRare acute idiopathic subdural hematoma: A case report and literature reviewRare acute idiopathic subdural hematoma: A case report and literature review Category: Article Type: Adilson de Oliveira, Wellingson da Silva Paiva, Manoel Jacobsen TeixeiraDepartment of Neurosurgery, Hospital das Clinicas da Faculdade de Medicina da USP, Sao Paulo, Brazil,Neurosurgery Service, Clinica Girassol, Luanda, Angola.Correspondence Address:Adilson de OliveiraDepartment of Neurosurgery,...Surgical...
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- Published Ahead-of-Print18F-FDG PET/CT Imaging Findings of LeprosyLeprosy is a chronic infectious disease caused by Mycobacterium leprae infection in susceptible individuals. Without proper clinical diagnosis and treatment, leprosy can have a poor prognosis; however, diagnosing leprosy is challenging. We present a case of leprosy with extensive skin infiltration and involvement of the turbinate mucosa and multiple lymph nodes with increased FDG uptake on PET/CT, mimicking malignancy. Received...
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Auditory hyper-responsiveness in autism spectrum disorder, terminologies and physiological mechanisms involved: systematic review: RESUMO Objetivo identificar as terminologias mais utilizadas para designar o comportamento desproporcional a determinados sons (CDS) no TEA e sua relação com as respectivas ferramentas para sua investigação, assim como sua ocorrência e desfechos. Estratégia de pesquisa Foram utilizadas as bases de dados: PubMed, PsycINFO, Web of Science, Scielo e Lilacs. As palavras-chave...
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http://goo.gl/0msigDIdentification of a minimal region of loss on chromosome 6q27 associated with poor survival of high-risk neuroblastoma patients.Related ArticlesIdentification of a minimal region of loss on chromosome 6q27 associated with poor survival of high-risk neuroblastoma patients. Cancer Biol Ther. 2020 Jan 20;:1-9 Authors: Ognibene M, Morini M, Garaventa A, Podestà M, Pezzolo A Abstract Patients with high-risk neuroblastoma (HR-NB) often initially respond to therapy, but afterward they...
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Online First ArticlesEpitope and Fc-mediated Crosslinking, but not High Affinity, Are Critical for Antitumor Activity of CD137 Agonist Antibody with Reduced Liver ToxicityCD137 (TNFRSF9, 4-1BB) agonist antibodies (mAb) have demonstrated potent anti-tumor activity with memory response while causing hepatotoxicity in mouse models. In clinical trials, the degrees of liver toxicity of anti-CD137 vary from grade 4 transaminitis (urelumab) to non-existent (utomilumab). To exploit the anti-tumor potential...
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Insulin Resistance and Free Androgen as Predictors for Ovarian Hyperstimulation Syndrome in Non-PCOS Women: Horm Metab ResDOI: 10.1055/a-1079-5342We evaluated the effect of insulin resistance and free androgen index (FAI) in non-PCOS (polycystic ovary syndrome) infertile women following controlled ovarian hyperstimulation. A prospective study was done on 144 infertile non-PCOS women with regular menstrual cycle. At first, insulin resistance (IR), free androgen index (FAI), PCOM (polycystic ovary...
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AGO2 phosphorylation by c-Src kinase promotes tumorigenesis: Publication date: March 2020Source: Neoplasia, Volume 22, Issue 3Author(s): Tianqi Liu, Hailong Zhang, Jiayu Fang, Zhi Yang, Ran Chen, Yanli Wang, Xian Zhao, Shengfang Ge, Jianxiu Yu, Jian HuangAbstractNumerous studies have reported that c-Src is highly expressed with high tyrosine kinase activity in a variety of tumors. However, it remains unclear whether c-Src contributes to the miRNA pathway. Here, we report that c-Src can interact with...
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Development, Characterization and Stability Evaluation of Ciprofloxacin-Loaded Parenteral Nutrition Nanoemulsions.: Related ArticlesDevelopment, Characterization and Stability Evaluation of Ciprofloxacin-Loaded Parenteral Nutrition Nanoemulsions.Pharm Dev Technol. 2020 Jan 22;:1-24Authors: Said Suliman A, Tom R, Palmer K, Tolaymat I, Younes H, Arafat B, Elhissi AMA, Najlah MAbstract In this study, two licensed total parenteral nanoemulsion formulations (Clinoleic® and Intralipid®) were...
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ScienceDirect Publication: American Journal of Infection ControlMidline or long peripheral catheters in difficult venous access conditions? A comparative study in patients with acute cardiovascular diseasesPublication date: Available online 21 January 2020Source: American Journal of Infection ControlAuthor(s): Adam Fabiani, Valentina Eletto, Lorella Dreas, Daria Beltrame, Gianfranco SansonBackgroundMidline catheters (MCs) are commonly inserted in patients with difficult venous access (DVA) needing...
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1algb4-ojrvz.htmlEnvironmental Science and Pollution Research, Vol. 27, Issue 2 - New Issue Alert.eml 2ao2lo-6iz3n.htmlThe latest articles and more from Genetics in Medicine.eml 3avcvp-uxgd2.htmlThe International Journal of Life Cycle Assessment, Vol. 25, Issue 2 - New Issue Alert.eml 4agkgc-g5obi.htmlJournal of Infrared, Millimeter, and Terahertz Waves, Vol. 41, Issue 2 - New Issue Alert.eml 5af8q6-ejhkq.htmlOral Oncology _ Volume 101.eml 6axd05-j95bv.htmlClinical Pharmacokinetics, Vol. 59, Issue...
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,http://www.surgicalneurologyinternational.com/Two cases of symptomatic common carotid artery occlusion treated by carotid endarterectomy with L-shaped ministernotomy.Related ArticlesTwo cases of symptomatic common carotid artery occlusion treated by carotid endarterectomy with L-shaped ministernotomy. Surg Neurol Int. 2020;11:1 Authors: Ogawa S, Ohgaki F, Mizuta R, Furuta Y, Fujitani S, Fujimoto S, Ota T Abstract Background: Common carotid artery occlusion (CCAO) is rare. Symptomatic lesions are...
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pubmed: "med oral patol oral...Immunohistochemical analysis of cancer-associated fibroblasts and podoplanin in head and neck cancer.Related ArticlesImmunohistochemical analysis of cancer-associated fibroblasts and podoplanin in head and neck cancer. Med Oral Patol Oral Cir Bucal. 2020 Jan 22;: Authors: Ramos-Vega V, Venegas Rojas B, Donoso Torres W Abstract BACKGROUND: To immunohistochemically evaluate the association between the presence of cancer-associated fibroblasts (CAFs) and the tumour expression...
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pubmed: frontiers immunologyThe Challenge of Modulating Heparan Sulfate Turnover by Multitarget Heparin Derivatives.Related ArticlesThe Challenge of Modulating Heparan Sulfate Turnover by Multitarget Heparin Derivatives. Molecules. 2020 Jan 17;25(2): Authors: Veraldi N, Zouggari N, de Agostini A Abstract This review comes as a part of the special issue "Emerging frontiers in GAGs and mimetics". Our interest is in the manipulation of heparan sulfate (HS) turnover by employing HS mimetics/heparin...
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African Health SciencesNCD epidemic and sexual reproductive health issues in the infectious disease worldNil.African Health SciencesFri Jan 17, 2020 16:09Association of Vitamin D deficiency and Vitamin D Receptor Gene Polymorphisms with Type 2 diabetes mellitus Saudi patientsBackground: Type 2 diabetes mellitus (T2DM) is a global problem. Association of multiple genes in T2DM becomes a hot point recently. This study was aimed to evaluate association of vitamin D receptor gene polymorphisms with...
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Annals of Indian Academy of Neurology : 2015 - 18(2)A Randomized Control Study on the Efficacy of Thymectomy in Patients with Nonthymomatous (without Chest Tumor) Myasthenia GravisJi Chen, Zhiming Chen, Feng Miao, Yang Song, Gang Chen, Yongjun Zhu, Liewen Pang, Jianying Xi, Chongbo Zhao, Xiaofeng ChenAnnals of Indian Academy of Neurology 2020 23(1):141-144Annals of Indian Academy of Neurology : 2015 - 18(2)Tue Jan 21, 2020 00:00Rationalization of using the MR diffusion imaging in B12 deficiencyHatice...
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Long-term stability of miniscrew anchored maxillary molar distalization in Class II treatment.Related ArticlesLong-term stability of miniscrew anchored maxillary molar distalization in Class II treatment. Angle Orthod. 2020 Jan 20;: Authors: Bechtold TE, Park YC, Kim KH, Jung H, Kang JY, Choi YJ Abstract OBJECTIVE: To investigate treatment stability of miniscrew-anchored maxillary distalization in Class II malocclusion. MATERIALS AND METHODS: This retrospective study included a distalization (n =...
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Plastique EsthétiqueComparaison des résultats de reconstruction mammaire immédiate par prothèse avec et sans radiothérapiePublication date: Available online 29 January 2020Source: Annales de Chirurgie Plastique EsthétiqueAuthor(s): L. Julien, J. Genet, N. Leymarie, J.-F. Honart, F. Rimareix, C. Mazouni, F. Kolb, K. De Frémicourt, A. Conversano, F. Marchal, E. Simon, M. Brix, B. SarfatiRésuméIntroductionLe cancer du sein et sa prise en charge restent un problème majeur de santé publique chez la femme....
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Plastic, Reconstructive & Aesthetic SurgeryLegal Disputes Involving Plastic Surgeries in Brazil: Main Causes of Patients 'Complaints, Trial Outcomes, and Influence of the Expert Report on the Results of Appellate CourtsAlthough the rise in lawsuits involving plastic surgeries is sensed across Brazilian tribunals, little is known about litigations considered by the trial courts and nothing regarding those judged by the appellate instance.Plastic, Reconstructive & Aesthetic SurgeryTue Feb...
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British Association of Plastic SurgeonsMeta-analysis on the comparative efficacy of drains, progressive tension sutures and subscarpal fat preservation in reducing complications of abdominoplastyPublication date: Available online 1 February 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Weiguang Ho, Christopher D Jones, Elizabeth Pitt, Marc-James HallamAbstractIntroductionAbdominoplasty is a popular aesthetic operation. Complication rates vary from 4-80%. To date,...
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Journal of Clinical MedicineJCM, Vol. 9, Pages 423: Are the Immune Properties of Mesenchymal Stem Cells from Wharton's Jelly Maintained during Chondrogenic Differentiation?JCM, Vol. 9, Pages 423: Are the Immune Properties of Mesenchymal Stem Cells from Wharton's Jelly Maintained during Chondrogenic Differentiation? Journal of Clinical Medicine doi: 10.3390/jcm9020423 Authors: Voisin Cauchois Reppel Laroye Louarn Schenowitz Sonon Poras Wang D. Carosella Benkirane-Jessel Moreau Rouas-Freiss Bensoussan...
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CellsCells, Vol. 9, Pages 363: Silencing Dicer-Like Genes Reduces Virulence and sRNA Generation in Penicillium italicum, the Cause of Citrus Blue MoldCells, Vol. 9, Pages 363: Silencing Dicer-Like Genes Reduces Virulence and sRNA Generation in Penicillium italicum, the Cause of Citrus Blue Mold Cells doi: 10.3390/cells9020363 Authors: Chunxiao Yin Hong Zhu Yueming Jiang Yang Shan Liang Gong The Dicer protein is one of the most important components of RNAi machinery because it regulates the production...
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AntioxidantsAntioxidants, Vol. 9, Pages 137: Post-Treatment with Erinacine A, a Derived Diterpenoid of H. erinaceus, Attenuates Neurotoxicity in MPTP Model of Parkinson's DiseaseAntioxidants, Vol. 9, Pages 137: Post-Treatment with Erinacine A, a Derived Diterpenoid of H. erinaceus, Attenuates Neurotoxicity in MPTP Model of Parkinson's Disease Antioxidants doi: 10.3390/antiox9020137 Authors: Lee Tung Teng Shen Hsieh Huang Lee Lee Chen Chen Huang Kuo Hericium erinaceus, a valuable pharmaceutical and...
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Gross type of hepatocellular carcinoma reflects the tumor hypoxia, fibrosis, and stemness-related marker expressionAbstractBackgroundHepatocellular carcinoma (HCC) is subclassified into five gross types, namely, vaguely nodular (VN), single nodular (SN), single nodular with extranodular growth (SNEG), confluent multinodular (CM), and infiltrative (INF) type. However, the pathological background underlying differences in biological behavior of different gross types of HCC remains unclear.MethodsThe...
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Perceived Feasibility, Acceptability, and Cultural Adaptation for a Mental Health Intervention in Rural HaitiAbstractMental healthcare is largely unavailable throughout Haiti, particularly in rural areas. The aim of the current study is to explore perceived feasibility, acceptability, and effectiveness of potential culturally adapted interventions to improve mental health among Haitian women. The study used focus group discussions (n = 12) to explore five potential interventions to promote mental...
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Mobile Electrocardiogram Monitoring and Health-Related Quality of Life in Patients With Atrial Fibrillation: Findings From the iPhone Helping Evaluate Atrial Fibrillation Rhythm Through Technology (iHEART) StudyBackground Atrial fibrillation (AF) is associated with high recurrence rates and poor health-related quality of life (HRQOL) but few effective interventions to improve HRQOL exist. Objective The aim of this study was to examine the impact of the "iPhone Helping Evaluate Atrial Fibrillation...
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Advanced Diffusion-Weighted Abdominal Imaging: Qualitative and Quantitative Comparison of High and Ultra-High: b: -Values for Lesion Detection and Image QualityIntroduction Magnetic resonance imaging (MRI) of the abdomen increasingly incorporates diffusion-weighted imaging (DWI) sequences. Whereas DWI can substantially aid in detecting and characterizing suspicious findings, it remains unclear to what extent the use of ultra-high b-value DWI might further be of aid for the radiologist especially...
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Infratemporal fossa surgical approaches to primary/recurrent malignancies of salivary origin: paradigm surgical shift, patient selection, and oncologic outcomesPurpose of review To review, the surgical approaches available on diagnosing a patient with salivary gland malignancy in the infratemporal fossa (ITF). To comment on patient evaluation and method of treatment selection. To identify and report on patient outcome data and make recommendations on future needs. Recent findings There is a need...
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: update for 2020Purpose of review This review summarizes the current knowledge regarding autosomal recessive hypercholesterolemia (ARH) and provides new insight into the natural history and therapeutic management of this lipid disorder. Recent findings Novel homozygous and compound heterozygous ARH-causing mutations have been reported in the literature, to date. The long-term follow-up of a cohort of ARH patients demonstrated that, despite intensive treatment with conventional lipid-lowering therapies,...
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Development of a Measure of Nociception for Patients with Severe Brain InjuryObjectives: Severe brain injury is often accompanied by painful comorbidities, and by concurrent limitations in the ability to report pain. Assessment of nociception aids diagnosis and helps balance reduction in suffering with avoidance of sedating medications. Existing assessment methods confound patients' level of consciousness with the intensity of nociception, complicating pain assessment as consciousness evolves. We...
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Nurses' Compliance With Bar-code Medication Administration Technology: Results of Direct Observation of Jordanian Nurses' PracticeMedication administration using bar-code medication administration technology enhances the verification of medication administration rights. Nurses' compliance with bar-code medication administration procedure is essential to maximize the benefits. This study evaluated the current rate of nurses' compliance with bar-code medication administration use through direct observation....
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The role of opioids in cancer progressionNo abstract availableApproaches to drug monitoring: partnering with the clinical laboratoryNo abstract availableOpioid-free and opioid-sparing anesthesiaNo abstract availableToxicity of agents used for opioid withdrawal: a case-based approachNo abstract available
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Pilot study assessing the rotterdam healthy aging score in a cohort of human immunodeficiency virus positive adults in Toronto, CanadaObjective: The Rotterdam Healthy Aging Score (HAS) is a validated multidimensional index constructed from five health domains. We describe the HAS distribution in a cohort of HIV-positive adults and correlate it with health outcomes. Design: A cross-sectional pilot study of 101 adults aged ≥40 years, on suppressive antiretroviral therapy attending a tertiary HIV clinic...
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All Tied Up: The Effect of Wearing a Necktie on Acoustic and Perceptual Measures of Male Solo SingingThe purpose of this study was to assess acoustically (long-term average spectra and multidimensional voice profile) and perceptually (participant perceived phonatory ease and expert listening panel) the effect of wearing a necktie on male singing in a solo setting. No study to date has assessed the potential effects of wearing neckties in a solo vocal setting. Among primary results: (a) statistically...
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Is There an Increasing Interest in Facial Feminization Surgery? A Search Trends AnalysisFacial feminization surgery (FFS) has increased in prevalence and recent studies show that transgender women are just as likely to want facial feminization surgery compared to genital affirmation surgery. While previous research has demonstrated an increase in individuals seeking gender affirmation surgery, little is known on the prevalence of facial feminization surgery. Categorizing the number of facial feminization...
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FREEPractice Advisory for the Perioperative Management of Patients with Cardiac Implantable Electronic Devices This practice advisory updates the "Practice Advisory for the Management of Patients with Cardiac Implantable Electronic Devices: Pacemakers and Implantable Cardioverter--Defibrillators: An Updated Report by the American Society of Anesthesiologists Task Force on Perioperative Management of Patients with Cardiac Implantable Electronic Devices," adopted by the American Society of Anesthesiologists...
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Consensus and Controversies Between Pain and Addiction Experts on the Prevention, Diagnosis, and Management of Prescription Opioid Use DisorderObjectives: Prescription opioid use disorder (POUD) is an established public health crisis in many countries, and current evidence indicates it is a growing problem in Europe. Many specialists play a role, including pain and addiction medicine specialists, in the diagnosis and management of POUD, but neither group can fully address these patients' needs alone....
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Thromboelastography versus standard coagulation testing in the assessment and reversal of coagulopathy among cirrhotics: a systematic review and meta-analysisThe utility of thromboelastography/thromboelastometry currently has unvalidated clinical benefit in the assessment and reversal of coagulopathy among cirrhotic patients as compared to standard coagulation testing. A novel systematic review and meta-analysis was conducted in order to assess pooled outcome data among patients receiving thromboelastography/thromboelastometry...
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The Increasing Exposure of the Global Population to Ionizing RadiationNo abstract availableEstimating Causal Effects of Particulate Matter Regulation on MortalityBackground: Estimating the causal effect of pollution on human health is integral for evaluating returns to pollution regulation, yet separating out confounding factors remains a perennial challenge. Methods: We use a quasi-experimental design to investigate the causal relationship between regulation of particulate matter smaller than 2.5...
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Prostate Benign DiseasesMagnetic resonance imaging (MRI) has been increasingly used in the detection, localization, and staging of prostate cancer. Because of its excellent soft tissue contrast and multiplane imaging, it can be also very useful in the evaluation of benign prostate diseases. Prostatic benign disorders have a high prevalence, vastly represented by benign prostatic hyperplasia and prostatitis. On the contrary, benign prostatic neoplasms are extremely rare, represented by multilocular...
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The correlation between IL-4 polymorphisms and colorectal cancer risk in a population in Northwest ChinaOur aim was to investigate whether polymorphisms in the interleukin-4 (IL-4) gene are associated with the risk of colorectal cancer (CRC) in a Chinese Han population. Six single-nucleotide polymorphisms (SNPs) in the IL-4 were genotyped by Agena MassARRAY in 248 CRC patients and 463 healthy controls. The association of IL-4 polymorphisms with CRC risk was assessed by genetic models, linkage disequilibrium,...
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Integration of EMT and cellular survival instincts in reprogramming of programmed cell death to anastasisAbstractApoptosis is a tightly controlled, coordinated cellular event responsible for inducing programmed cell death to rid the body of defective or unfit cells. Inhibition of apoptosis is, therefore, an essential process for cancer cells to harness. Genomic variants in apoptotic-controlling genes are highly prevalent in cancer and have been identified to induce pro-proliferation and pro-survival...
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Correction to: High efficiency inactivation of microalgae in ballast water by a new proposed dual-wave UV-photocatalysis system (UVA/UVC-TiO 2 )In the third paragraph of Introduction, the sentence "Few scholars have conducted static studies on dual-wavelength UV photocatalytic technologies (Ma 2018)".Size-specific responses of the amphipod Eohaustorius estuarius to clay in sediment toxicity testingAbstractA number of lines of evidence suggest that the amphipod Eohaustorius estuarius has variable...
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An insight into the 50th-anniversary edition of Ingle's EndodonticsAbdullah R AlShammerySaudi Journal of Oral Sciences 2020 7(1):1-2Bioactive glass in dentistry: A systematic reviewKashmira Sawant, Ajinkya M PawarSaudi Journal of Oral Sciences 2020 7(1):3-10Bioactive glass (BAG) is a benevolent biocompatible material used as an adjunct to various materials used in dentistry. BAG is proved to have a beneficent effect in promoting material–tissue bond. The objective is to analyze significant information...
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Detecting heterogeneity in and between breast cancer cell linesAbstractBackgroundCellular heterogeneity in tumor cells is a well-established phenomenon. Genetic and phenotypic cell-to-cell variability have been observed in numerous studies both within the same type of cancer cells and across different types of cancers. Another known fact for metastatic tumor cells is that they tend to be softer than their normal or non-metastatic counterparts. However, the heterogeneity of mechanical properties in...
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Visual acuity assessment and the knowledge of road safety rules among commercial motorcyclist in Ekpoma town, Southern NigeriaInnocent O Alenoghena, N.S. Awunor, W.A. OvienraSub-Saharan African Journal of Medicine 2019 6(3):111-115Introduction: Motorcycle injuries, particularly from low income countries like Africa and Asia contribute significantly to road traffic injuries globally, according to recent estimates by the World Health Organization. Objective: To determine the prevalence of visual acuity...
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Cost-Neutral Optimization of Pazopanib Exposure by Splitting Intake Moments: A Prospective Pharmacokinetic Study in Cancer PatientsAbstractBackground and ObjectivePazopanib is an oral tyrosine kinase inhibitor used in the treatment of renal cell carcinoma and soft-tissue sarcoma. At the approved dose of 800 mg once daily (QD), 16–20% of patients are being underdosed and at risk of decreased efficacy. This study aimed to show whether splitting intake moments, as a cost-neutral alternative to a dose...
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Life cycle assessment of organic and conventional non-Bt cotton products from MaliAbstractIntroductionCotton is the most produced natural fibre in the world, with an annual output of 23 million t of lint in the period 2000–2013. Africa produced in average 6% of that output, and despite being a relatively minor contributor to global cotton supply chains, it has been estimated that a large percentage of the continent's population depends on cotton cultivation for their livelihood. Most published cotton...
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A Phase I dose-escalation, pharmacokinetics and food-effect study of oral donafenib in patients with advanced solid tumoursAbstractPurposeThis Phase I study evaluated the safety, tolerability, food effects, pharmacodynamics, and pharmacokinetics of donafenib in patients with advanced solid tumours.MethodsEligible patients received a single dose of donafenib (50 mg, 100 mg, 200 mg, 300 mg, or 400 mg) and were then observed over a 7-day period; thereafter, each patient received the corresponding dose...
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