Related Articles Auditory Brainstem Response in Preterm Infants in the Neonatal Intensive Care Unit. Otolaryngol Head Neck Surg. 2020 Sep 15;:194599820955181 Authors: Raposo D, Orfão J, Menezes M, Trindade-Soares M, Guimarães A, Freire F Abstract OBJECTIVE: To analyze auditory brainstem response (ABR) findings of preterm and term infants in the neonatal intensive care unit (NICU) with perinatal problems. STUDY DESIGN: Case series...
Related Articles Unique Challenges for Otolaryngology Patients During the COVID-19 Pandemic. Otolaryngol Head Neck Surg. 2020 Sep 15;:194599820954838 Authors: Ghulam-Smith M, Choi Y, Edwards H, Levi JR Abstract The coronavirus disease 2019 (COVID-19) pandemic has drastically altered health care delivery and utilization. The field of otolaryngology in particular has faced distinct challenges and an increased risk of transmission as day-to-day...
Related Articles Association of Clinicopathological Features With Outcome in Chondrosarcomas of the Head and Neck. Otolaryngol Head Neck Surg. 2020 Sep 15;:194599820957271 Authors: Asioli S, Ruengwanichayakun P, Zoli M, Guaraldi F, Sollini G, Greco P, Facco C, Gibertoni D, Jiménez BV, Benini S, Turri-Zanoni M, Pasquini E, Mazzatenta D, Foschini MP, Righi A Abstract OBJECTIVE: The aim of this study is to assess the association between clinical...
Related Articles Communicative Participation and Quality of Life in Pretreatment Oral and Oropharyngeal Head and Neck Cancer. Otolaryngol Head Neck Surg. 2020 Sep 15;:194599820950718 Authors: Sauder C, Kapsner-Smith M, Baylor C, Yorkston K, Futran N, Eadie T Abstract OBJECTIVE: To determine how communicative participation is affected in patients with oral and oropharyngeal head and neck cancers (HNCs) pretreatment and whether communication...
Related Articles Airborne Aerosolized Mouse Cytomegalovirus From Common Otolaryngology Procedures: Implications for COVID-19 Infection. Otolaryngol Head Neck Surg. 2020 Sep 15;:194599820957966 Authors: Sayahi T, Nielson C, Yu Y, Neuberger K, Seipp M, Firpo MA, Kelly K, Park AH Abstract OBJECTIVES: To determine whether common otolaryngology procedures generate viable aerosolized virus through a murine cytomegalovirus (mCMV) model for infection....
Related Articles Risk Factors for Post-acute care Following Free Flap Reconstruction of the Oral Cavity. Otolaryngol Head Neck Surg. 2020 Sep 15;:194599820955175 Authors: Lepse J, Sykes KJ, Kakarala K Abstract OBJECTIVE: Identify previously unreported factors that predict the need for post-acute care after free flap reconstruction of the oral cavity. STUDY DESIGN: Retrospective cohort study. SETTING: Single academic...
Related Articles Demographic and Clinical Characteristics Associated With Adherence to Guideline-Based Polysomnography in Children With Down Syndrome. Otolaryngol Head Neck Surg. 2020 Sep 15;:194599820954837 Authors: Knollman PD, Heubi CH, Wiley S, Smith DF, Shott SR, Ishman SL, Meinzen-Derr J Abstract OBJECTIVES: To compare the demographic and clinical characteristics of children with Down syndrome who did and did not receive polysomnography...
Related Articles Timing the First Pediatric Tracheostomy Tube Change: A Randomized Controlled Trial. Otolaryngol Head Neck Surg. 2020 Sep 15;:194599820954137 Authors: Chorney SR, Patel RC, Boyd AE, Stow J, Schmitt MM, Lipman D, Dailey JF, Nhan C, Giordano T, Sobol SE Abstract OBJECTIVE: The first pediatric tracheostomy tube change often occurs within 7 days after placement; however, the optimal timing is not known. The primary objective...
Related Articles Racial and Insurance Inequalities in Access to Early Pediatric Cochlear Implantation. Otolaryngol Head Neck Surg. 2020 Sep 15;:194599820953381 Authors: Liu X, Rosa-Lugo LI, Cosby JL, Pritchett CV Abstract OBJECTIVE: To evaluate the association between race/ethnicity and insurance status on the access to early cochlear implantation. STUDY DESIGN: Population-based retrospective analysis of pediatric cochlear implantation...
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00737
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08068
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08290
[ASAP] Regulating Photocatalysis by Spin-State Manipulation of Cobalt in Covalent Organic Frameworks
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07206
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06618
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04619
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05488
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02772
Related Articles Language proficiency and biologics access: a population study of psoriasis patients in the United States. J Dermatolog Treat. 2020 Sep 14;:1-5 Authors: Chat VS, Hekmatjah J, Sierro TJ, Kassardjian AA, Read C, Armstrong AW Abstract BACKGROUND: Language proficiency plays an important role in healthcare choices and access. Differences in access to biologic medications exist, but it is unknown how much English proficiency influences...
Related Articles Management of Graves'Thyroidal And Extrathyroidal Disease - An Update. J Clin Endocrinol Metab. 2020 Sep 14;: Authors: Kahaly GJ Abstract CONTEXT: Invited update on the management of systemic autoimmune Graves 'disease (GD) and associated orbitopathy (GO). EVIDENCE ACQUISITION: Guidelines, pertinent original articles, systemic reviews, and meta-analyses. EVIDENCE SYNTHESIS: Thyrotropin receptor antibodies (TSH-R-Ab),...
Related Articles Hip structural analysis reveals impaired hip geometry in girls with type 1 diabetes. J Clin Endocrinol Metab. 2020 Sep 14;: Authors: Joseph TV, Caksa S, Misra M, Mitchell DM Abstract CONTEXT: Among patients with type 1 diabetes (T1D), the risk of hip fracture is up to six-fold greater than that of the general population. However, the cause of this skeletal fragility remains poorly understood. OBJECTIVE: To assess differences...
Related Articles Predictors of the Response to Dopaminergic Therapy in Patients with Prolactinoma. J Clin Endocrinol Metab. 2020 Sep 15;: Authors: Hage C, Salvatori R Abstract PURPOSE: Withdrawal of dopamine agonist (DA) therapy in patients with prolactinoma who are controlled by a small dose of medication is recommended by several guidelines. So far, the likelihood of reaching withdrawal conditions based on baseline characteristics remains...
Related Articles The 15-epilipoxin-A4 pathway (ATL) with prophylactic aspirin in preventing preeclampsia: a longitudinal-cohort study. J Clin Endocrinol Metab. 2020 Sep 15;: Authors: Shanmugalingam R, Wang X, Motum P, Fulcher I, Lee G, Kumar R, Hennessy A, Makris A Abstract INTRODUCTION: The benefit of aspirin in preventing preeclampsia is increasingly recognised, however, its mechanism of action remains unclear. Non-obstetric studies have described...
Related Articles Intensity modulated radiotherapy (IMRT) for pituitary somatotroph adenomas. J Clin Endocrinol Metab. 2020 Sep 15;: Authors: Lian X, Shen J, Gu Z, Yan J, Sun S, Hou X, You H, Xing B, Zhu H, Shen J, Zhang F Abstract OBJECTIVE: To summarize our experience in the treatment of pituitary somatotroph adenomas by fractionated intensity modulated radiotherapy (IMRT), describe the treatment outcomes and determine predictors. ...
Related Articles Approach to the Treatment of a Patient with an Aggressive Pituitary Tumor. J Clin Endocrinol Metab. 2020 Sep 15;: Authors: Lin AL, Donoghue MTA, Wardlaw SL, Yang TJ, Bodei L, Tabar V, Geer EB Abstract A small subset of pituitary adenomas grow despite maximal treatment with standard therapies; namely, surgery and radiotherapy. These aggressive tumors demonstrate two patterns of growth: they may be locally aggressive or metastasize...
Related Articles Risk Assessment of Autopsy-Acquired SARS-CoV-2 Coronavirus (COVID-19). Arch Pathol Lab Med. 2020 Sep 15;: Authors: Parkash V, Smith SM PMID: 32931576 [PubMed - as supplied by publisher]
Related Articles In Reply. Arch Pathol Lab Med. 2020 Sep 15;: Authors: Davis GG, Williamson AK PMID: 32931577 [PubMed - as supplied by publisher]
In this 7‐day randomized controlled trial we found that a novel fiber supplement from the Mexican nopal cactus improved adequate relief in patients with IBS, irrespective of IBS subtype, sex or age, compared to placebo. Notably, a dose of 20 and 30 g/d resulted in the most favourable effects, suggesting that these doses may have potential clinical effectiveness in IBS management. Abstract Background Clinical guidelines provide limited and conflicting recommendations regarding dietary fiber...
Abstract Background STW 5 is a combination of nine medicinal herbal extracts and used to treat functional gastrointestinal disorders including functional dyspepsia. It has a region‐specific effect by relaxing the proximal and contracting the distal stomach. The research combination STW 5‐II (Iberogast® Advance) lacks three herbal extracts but seems clinically as effective as STW 5. However, the action of STW 5‐II on gastric motility is unknown. Methods In vitro circular and longitudinal...
Related Articles Assesment of Prelacrimal Recess in Patients With Maxillary Sinus Hypoplasia Using Cone Beam Computed Tomography. Am J Rhinol Allergy. 2020 Sep 14;:1945892420959592 Authors: Duman SB, Gumussoy İ Abstract BACKGROUND: The prelacrimal recess approach, is frequently preferred in creating a minimally invasive surgical corridors. OBJECTIVE: The aim of this study was to evaluate the Prelacrimal recess (PLR) anatomy using...
Related Articles Pembrolizumab in the preoperative setting of triple-negative breast cancer: safety and efficacy. Expert Rev Anticancer Ther. 2020 Sep 15;: Authors: Barroso-Sousa R, Tolaney SM Abstract INTRODUCTION: In 2019, the PD-L1 inhibitor atezolizumab became the first immune checkpoint inhibitor approved for treatment in patients with breast cancer. The approval is restricted to patients with metastatic triple-negative breast cancer (TNBC)...
Related Articles Patient selection and risk factors in the changing treatment landscape of metastatic renal cell carcinoma. Expert Rev Anticancer Ther. 2020 Sep 15;: Authors: Abdou E, Pedapenki RM, Abouagour M, Zar AR, Anwar E, Elshourbagy D, Al-Shamsi H, Grande E Abstract INTRODUCTION: The approval of combination treatments for metastatic renal cell carcinoma (mRCC) represents a major change in the clinical management of this malignancy. Updated...
Related Articles ASSOCIATION BETWEEN OBJECTIVE RESPONSE RATE AND OVERALL SURVIVAL IN METASTATIC NEUROENDOCRINE TUMORS TREATED WITH RADIOEMBOLIZATION: A SYSTEMATIC LITERATURE REVIEW AND REGRESSION ANALYSIS. Expert Rev Anticancer Ther. 2020 Sep 15;: Authors: Pollock RF, Brennan VK, Peters R, Paprottka PM Abstract OBJECTIVES Neuroendocrine tumors (NETs) are a heterogeneous group of cancers arising from neuroendocrine cells. The aim was to model...
Related Articles Real-world evidence of the efficacy and tolerability of trabectedin in patients with advanced soft-tissue sarcoma. Expert Rev Anticancer Ther. 2020 Sep 15;: Authors: de Sande González LM, Martin-Broto J, Kasper B, Blay JY, Le Cesne A Abstract INTRODUCTION: The efficacy and tolerability of trabectedin in patients with soft tissue sarcoma (STS) have been confirmed by various clinical studies involving lipo- and leiomyosarcomas...
Related Articles The pressure effects of different commercially available beverages on food boluses in vitro. Eur Arch Otorhinolaryngol. 2020 Sep 15;: Authors: Ibrahim Y, Browning S Abstract PURPOSE: Acute oesophageal food impaction is a common and potentially life-threatening condition. Effervescent agents have been used to manage these patients. To date, there have not been any studies comparing the differences in commercially available beverages...
Kasai operation is widely performed for biliary atresia (BA), as it improves the prognosis. Biliary tract cancer has rarely been reported as a complication after Kasai operation. A 17‐year‐old man underwent liver transplantation for progressive jaundice and liver dysfunction after Kasai operation for BA. A macroscopic examination of the explanted liver revealed a 3.6‐cm‐diameter mass in the hilus of the explanted liver. The tumor consisted of an atypical proliferation of glandular cells in the collagenous...
Related Articles [Tumor microenvironment in salivary gland carcinomas: Consequences for new therapeutic concepts]. HNO. 2020 Sep 14;: Authors: Meyer MF, Arolt C, Kansy BA, Doescher J, Quaas A, Beutner D, Lang S, Klußmann JP Abstract INTRODUCTION: Salivary gland carcinomas (SGCs) are rare tumors which represent a challenge for diagnosis and therapy due to their histological diversity and the different disease courses depending on the respective...
Related Articles [Epistaxis and anticoagulation therapy: an analysis based on health insurance data from Lower Saxony]. HNO. 2020 Sep 14;: Authors: Althaus AE, Arendt U, Hoffmann F, Lüske J, Freitag MH, Jobski K, Dörks M Abstract BACKGROUND: Epistaxis is a common symptom in the medical practice. It is associated with various comorbidities and the use of medications, especially anticoagulants. Despite the high lifetime prevalence, there...
Related Articles [Functional outcome after transmandibular resection and primary chemoradiation in advanced oropharyngeal squamous cell carcinoma]. HNO. 2020 Sep 14;: Authors: Knopf A, Mansour N, Hofauer B, Johnson F, Bier H, Wakonig F, Teutsch S Abstract OBJECTIVE: The aim of this study was to assess the functional outcome after transmandibular resection and reconstruction via a radial forearm flap (TMR+RFF) compared to primary chemoradiotherapy...
Related Articles [Plastic reconstructive surgery in patients with oropharyngeal tumors]. HNO. 2020 Sep 14;: Authors: Remmert S, Hasenberg S Abstract Oropharyngeal tumors can cause severe dysfunctions, which are often worsened by surgical and/or radiotherapy. The severity and type of dysfunction depends on the extent and localization of the resection. In general, entire organ resections lead to greater impairment than partial resections,...
Related Articles ["Online from tomorrow on please": comparison of digital framework conditions of curricular teaching at national university ENT clinics in times of COVID-19 : Digital teaching at national university ENT clinics]. HNO. 2020 Sep 14;: Authors: Offergeld C, Ketterer M, Neudert M, Hassepaß F, Weerda N, Richter B, Traser L, Becker C, Deeg N, Knopf A, Wesarg T, Rauch AK, Jakob T, Ferver F, Lang F, Vielsmeier V, Hackenberg S, Diensthuber M, Praetorius...
Related Articles [Impact of CI use and CI fitting on speech production in very early cochlear-implanted infants]. HNO. 2020 Sep 15;: Authors: Glaubitz C, Liebscher T, Hoppe U Abstract BACKGROUND: Children's age at implantation is an important factor for their outcome in auditory and language skills with a cochlear implant (CI). CI use and frequency of CI fitting may also influence speech performance. Purpose of this study was to evaluate...
The submission deadline is October 16, 2020. Created and awarded for the first time by the SLA in 2014, this award honors an SLA member or members for work that effectively impacts public awareness of social issues involving language and communication and/or represents a significant service to a particular community outside of the academy. Such work may be in any medium including but not limited to books, reports, exhibits, pedagogical materials/curricula, documentary films, newspaper or...
Dear SLA members and friends, The SLA Executive Board in please to invite you to the SLA Fall Open Forum, to be hosted on zoom on Thursday, October 1st, 6:00-8:00 EST (3:00-5:00 PST). Sponsored by the Society for Linguistic Anthropology, the SLA Open Forum invites participants to share their vision for the association with the SLA Executive Committee in an informal setting. We welcome input regarding SLA-related activities, projects, and new initiatives, with the aim of forging common goals...
Related Articles LncRNA WWOX-AS1 sponges miR-20b-5p in hepatocellular carcinoma and represses its progression by upregulating WWOX. Cancer Biol Ther. 2020 Sep 15;:1-10 Authors: Xu D, Liu X, Wu J, Wang Y, Zhou K, Chen W, Chen J, Chen C, Chen L Abstract Increasing evidence has revealed that long noncoding RNAs (lncRNAs) emerge as pivotal regulators in diverse cancers, including hepatocellular carcinoma (HCC). This study was conducted to investigate...
Related Articles COVID-19 lockdown and beyond: Home practice solutions for developing microsurgical skills. J Plast Reconstr Aesthet Surg. 2020 Aug 20;: Authors: Higgins GC, Thomson SE, Baker J, Honeyman C, Kearns M, Roberts J, Tay S PMID: 32928686 [PubMed - as supplied by publisher]
Related Articles Granulomas and nongranulomatous nodules after filler injection: Different complications require different treatments. J Plast Reconstr Aesthet Surg. 2020 Aug 13;: Authors: Modarressi A, Nizet C, Lombardi T Abstract Dermal fillers are widely used for facial rejuvenation and reconstruction and present fewer risks than surgical approaches. Nevertheless, several complications may occur, including nodule formation. A nodule is a...
Purpose: To assess palbociclib in combination with trastuzumab with or without endocrine therapy in patients with HER2-positive advanced breast cancer. Patients and Methods: PATRICIA is a prospective, open-label, multicenter phase II trial. Patients had received 2-4 prior lines of anti-HER2-based regimens. Treatment consisted of palbociclib 200 mg daily for 2 weeks and 1 week off plus trastuzumab. The study was based on a Simon 2-stage design comprising 3 cohorts: estrogen receptor (ER)-negative...
Related Articles Cerebrospinal fluid leak from lateral orbit during exenteration for mucormycosis. BMJ Case Rep. 2020 Sep 13;13(9): Authors: Arora K, Mehta A, Virk RS, Saini M Abstract We describe an elderly diabetic patient presenting with sudden onset right-sided proptosis and vision loss secondary to rhino-orbital mucormycosis and central retinal vascular occlusion. He underwent orbital exenteration that was complicated by intraoperative...
Related Articles Spontaneous Intracranial Hypotension and Its Management with a Cervical Epidural Blood Patch: A Case Report. Am J Case Rep. 2020 Sep 15;21:e925986 Authors: Akbar RA, Khan AA, Fernandes GM, Ahmed Mohamed AZ, Elsotouhy A, Ali YOM Abstract BACKGROUND Spontaneous intracranial hypotension (SIH) is a rare cause of postural headache. In most patients, the site of cerebrospinal fluid (CSF) leak is at the cervical or thoracic spinal...
Related Articles Dizziness and COVID-19. Ear Nose Throat J. 2020 Sep 15;:145561320959573 Authors: Saniasiaya J, Kulasegarah J PMID: 32931322 [PubMed - as supplied by publisher]
Related Articles Alveolar Soft-Part Sarcoma in Olfactory Cleft: A Case Report and Clinicopathological Review. Ear Nose Throat J. 2020 Sep 15;:145561320955134 Authors: Alromaih S, Alqaryan S, Alabood S, Alabaishi S, Ajlan A, Alsuhaibani A, Sumaily I, Alsolami A Abstract Sinonasal alveolar soft-part sarcoma (ASPS) is a rare malignant disease that comprises 0.4% to 1.2% of all soft-tissue sarcomas. Alveolar soft-part sarcoma is usually difficult...
Related Articles Ulcerative Warthin Tumor: A Case Report and Review of the Literature. Ear Nose Throat J. 2020 Sep 15;:145561320957574 Authors: Hung CJ, Kang BH, Wang JS, Lin YS Abstract Warthin tumor with ulceration of the surrounding skin is extremely rare, making it difficult to differentiate from parotid cancer in the clinical setting. We report a 65-year-old man with a Warthin tumor in the right parotid gland that had ulceration of...
Related Articles Preoperative four-dimensional computed tomography imaging and simulation of a fibreoptic route for awake intubation in a patient with an epiglottic mass. Br J Anaesth. 2020 09;125(3):e290-e292 Authors: Zhou Z, Zhao X, Zhang C, Yao W PMID: 32654748 [PubMed - indexed for MEDLINE]
Related Articles Vestibular and cochlear nerve enhancement on MRI and its correlation with vestibulocochlear functional deficits in patients with Ramsay Hunt syndrome. Auris Nasus Larynx. 2020 Sep 11;: Authors: Takahashi M, Sato G, Toda N, Azuma T, Nakamura K, Iwasaki H, Miyoshi H, Matsuda K, Kitamura Y, Abe K, Takao S, Harada M, Takeda N Abstract OBJECTIVE: The correlation between enhancement of the vestibulocochlear nerves on gadolinium-enhanced...
New Findings What is the central question of this study? Insulin like growth factor (IGF) 1 and its major binding protein IGFBP3 involves in collagen deregulation in several cardiovascular diseases. The role of IGFBP3 in thoracic aortic dissection and whether it regulates AoSMCs phenotypic switch have not been fully unveiled yet. What is the main finding and its importance? We demonstrate for the first time that IGFBP3 inhibits AoSMCs phenotypic switch from contractile phenotype...
New Findings What is the central question of this study? Dose VEGF expressed by both endothelial cells and skeletal myofibers maintain the number of skeletal muscle capillaries and regulate endurance exercise. What is the main finding and its importance? VEGF expressed by both endothelial cells and skeletal myofibers is not essential for maintaining capillary number but does contribute to exercise performance. Abstract Many chronic diseases lead to exercise intolerance,...
Related Articles Ineffective Subtilisin/Kexin Type 9 (PCSK9) Inhibitors Monotherapy in Dyslipidemia with Low-Density Lipoprotein Cholesterol (LDL-C) Receptor Abnormalities: A Report of 2 Cases. Am J Case Rep. 2020 Sep 15;21:e923722 Authors: Matta A, Taraszkiewicz D, Bongard V, Ferrières J Abstract BACKGROUND Real-life data on the efficacy of monotherapy with PCSK9 inhibitors are scarce. Most cohort studies have examined populations that are...
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36 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2020/09/16PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Related Articles Daring discourse: should the ESP block be renamed RIP II block? Reg Anesth Pain Med. 2020 Sep 14;: Authors: Lonnqvist PA, Karmakar MK, Richardson J, Moriggl B Abstract During the time period 1984 to the turn of the millennium, interpleural nerve blockade was touted as a very useful regional anesthetic nerve blockade for most procedures or conditions that involved the trunk and was widely practiced despite the lack of proper...
Related Articles Cadaveric study identifying clinical sonoanatomy for proximal and distal approaches of ultrasound-guided intercostobrachial nerve block. Reg Anesth Pain Med. 2020 Sep 14;: Authors: Samerchua A, Leurcharusmee P, Panjasawatwong K, Pansuan K, Mahakkanukrauh P Abstract BACKGROUND AND OBJECTIVES: The intercostobrachial nerve (ICBN) has significant anatomical variation. Localization of the ICBN requires an operator's skill. This...
Related Articles Point-of-care ultrasound for the pediatric regional anesthesiologist and pain specialist: a technique review. Reg Anesth Pain Med. 2020 Sep 14;: Authors: Kars MS, Gomez Morad A, Haskins SC, Boublik J, Boretsky K Abstract Point-of-care ultrasound (PoCUS) has been well described for adult perioperative patients; however, the literature on children remains limited. Regional anesthesiologists have gained interest in expanding...
Related Articles Sleep-disordered breathing in patients on opioids for chronic pain. Reg Anesth Pain Med. 2020 Sep 14;: Authors: Selvanathan J, Peng PWH, Wong J, Ryan CM, Chung F Abstract The past two decades has seen a substantial rise in the use of opioids for chronic pain, along with opioid-related mortality and adverse effects. A contributor to opioid-associated mortality is the high prevalence of moderate/severe sleep-disordered breathing,...
Related Articles Role of peripheral sensory neuron mu-opioid receptors in nociceptive, inflammatory, and neuropathic pain. Reg Anesth Pain Med. 2020 Sep 14;: Authors: Barpujari A, Ford N, He SQ, Huang Q, Gaveriaux-Ruff C, Dong X, Guan Y, Raja S Abstract BACKGROUND AND OBJECTIVE: The role of peripheral mu-opioid receptors (MOPs) in chronic pain conditions is not well understood. Here, we used a combination of mouse genetics, behavioral assays,...
Related Articles Caudal analgesia versus abdominal wall blocks for pediatric genitourinary surgery: systematic review and meta-analysis. Reg Anesth Pain Med. 2020 Sep 14;: Authors: Desai N, Chan E, El-Boghdadly K, Albrecht E Abstract BACKGROUND: Caudal block is a well-established technique for providing perioperative analgesia in pediatric genitourinary surgery, but abdominal wall blocks such as ilioinguinal-iliohypogastric (II-IH) and...
Related Articles Peripartum factors associated with subacute pain after childbirth. Reg Anesth Pain Med. 2020 Sep 14;: Authors: Tan HS, Tan CW, Sultana R, Shah M, Leong WL, Sng DD, Sia ATH, Sng BL PMID: 32928997 [PubMed - as supplied by publisher]
Related Articles Evaluation of nerve capture using classical landmarks for genicular nerve radiofrequency ablation: 3D cadaveric study. Reg Anesth Pain Med. 2020 Sep 14;: Authors: Tran J, Peng P, Agur A Abstract BACKGROUND AND OBJECTIVES: Radiofrequency (RF) denervation of the superolateral genicular nerve (SLGN), superomedial genicular nerve (SMGN) and inferomedial genicular nerve (IMGN) is commonly used to manage chronic knee joint pain....
The majority of parthenogenetic vertebrates derive from hybridization between sexually reproducing species, but the exact number of hybridization events ancestral to currently extant clonal lineages is difficu...
As global change and anthropogenic pressures continue to increase, conservation and management increasingly needs to consider species’ potential to adapt to novel environmental conditions. Therefore, it is imp...
Abstract Human papillomavirus (HPV) vaccine offers protection of between 80 and 100% for anogenital warts and 60–80% in reducing the incidence of pre-malignant lesions from cervical cancer. However, uptake remains low in Nigeria among adolescent girls. This study was a qualitative study that assessed mothers’ acceptability and concerns regarding uptake of HPV vaccine by their adolescent daughters. In-depth interviews were conducted with 20 mothers of adolescents girls aged 9–15 years....
Related Articles Can Wharton jelly derived or adipose tissue derived mesenchymal stem cell can be a treatment option for duchenne muscular dystrophy? Answers as transcriptomic aspect. Am J Stem Cells. 2020;9(4):57-67 Authors: Sun E, Karaoz E Abstract INTRODUCTION: Mesenchymal stem cells (MSCs) are able to differentiate into several cell lineages including skeletal muscle. In addition to their differentiation capacities, they have the ability...
The Central Highland Plateau of Madagascar is largely composed of grassland savanna, interspersed with patches of closed-canopy forest. Conventional wisdom has it that these grasslands are anthropogenic in nature, having been created very recently via human agricultural practices. Yet, the ancient origins of the endemic grasses suggest that the extensive savannas are natural biomes, similar to others found around the globe. We use a phylogeographic approach to compare these two competing scenarios....
Related Articles In Silico and in Vitro Study of Trace Amines (TA) and Dopamine (DOP) Interaction with Human Alpha 1-Adrenergic Receptor and the Bacterial Adrenergic Receptor QseC. Cell Physiol Biochem. 2020 Sep 16;54(5):888-898 Authors: Luqman A, Kharisma VD, Ruiz RA, Götz F Abstract BACKGROUND/AIMS: Trace amines (TA) are small organic compounds that have neuromodulator activity due to their interaction with some neuron-related receptors, such...
Abstract Drug delivery to the brain is greatly hampered by the presence of the blood‐brain barrier (BBB) which tightly regulates the passage of molecules from blood to brain and vice versa. Nanocarriers, in which drugs can be encapsulated, can move across the blood‐brain barrier (BBB) via the process of transcytosis, thus showing promise to improve drug delivery to the brain. Here, we demonstrate the use of natural nanovesicles, i.e., exosomes, derived from C17.2 neural stem cells (NSCs) to efficiently...
Current plasmonic photocatalysts are mainly based on noble metal nanoparticles and rarely work in the infrared (IR) light range. Here, cost‐effective Bi 2 O 3‐ x with oxygen vacancies was formed in situ on commercial bismuth powder by calcination at 453.15 K in atmosphere. Interestingly, defects introduced into Bi 2 O 3‐ x simultaneously induced a localized surface plasmon resonance (LSPR) in the wavelength range of 600‐1400 nm and enhanced the adsorption for CO 2 molecules, which enabled...
Near‐infrared (NIR) activatable fluorescent probes have been considered to be the effective edge tools for the investigation of cell biology and disease diagnosis because of their outstanding advantages. Related genes involved in tumorigenesis and progression regulate the overexpression of certain enzymes. Owing to the distinctive characteristics of quick reaction time and favorable pharmacokinetics, enzyme‐reactive NIR optical probes have shown great potential in the diagnosis of tumorigenesis and...
Electrochemical sensing performance is often compromised by electrode biofouling (e.g., protein nonspecific binding) in complex biological fluids; however, the design and construction of a robust biointerface with superior antifouling ability and high tolerance of free radicals and excellent electrochemical performance remains a great challenge. Herein, inspired by nature, we demonstrate a robust polydopamine‐engineered biointerfacing, to tailing zwitterionic molecules (i.e., sulfobetaine methacrylate,...
The electrochemical reduction of N 2 to NH 3 is emerging as a promising alternative for sustainable and distributed production of NH 3 . However, the development has been impeded by difficulties in N 2 adsorption, protonation of *NN and inhibition of competing hydrogen evolution. To address the issues, we design a catalyst with diatomic Pd‐Cu sites on N‐doped carbon by modulation of single‐atom Pd sites with Cu. The introduction of Cu not only shifts the partial density states of Pd toward...
Discrepancies in mitochondrial and nuclear genetic data are often interpreted as evidence of hybridisation. We re-examined reports of hybridisation in three cryptic stingless bee species in the genus Tetragonula in South East Queensland, Australia (T. carbonaria, T. davenporti, and T. hockingsi). Previous studies on this group using microsatellite markers proposed that occasional hybrids are found. In contrast, we find that allele frequencies at neutral regions of the nuclear genome, both microsatellites...
Disruption of placental gene expression contributes to several congenital developmental disorders in humans, and may play an important role in the evolution of reproductive barriers between species. The placenta is also highly enriched for interacting genes showing parent-of-origin or imprinted expression, which is thought to have evolved to mitigate parental conflict within this extra-embryonic tissue. However, relatively little is known about the broader organization, functional integration, and...
Related Articles Development of graphene based nanocomposites towards medical and biological applications. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):1189-1205 Authors: Mousavi SM, Low FW, Hashemi SA, Lai CW, Ghasemi Y, Soroshnia S, Savardashtaki A, Babapoor A, Pynadathu Rumjit N, Goh SM, Amin N, Tiong SK Abstract Graphene and its derivative materials present high potential towards medical and biological applications, including drug...
Abstract Purpose Excessive daytime sleepiness (EDS) is commonly reported in patients with cancer, and it is also a cardinal feature of central disorders of hypersomnolence. Multiple sleep latency testing (MSLT) is used for objective assessment. Methods A retrospective review of patients with cancer history who underwent formal sleep evaluation and...
Abstract Mimetic systems allow us to address the question of whether the same genes control similar phenotypes in different species. Although widespread parallels have been found for major effect loci, much less is known about genes that control quantitative trait variation. In this study, we identify and compare the loci that control subtle changes in the size and shape of forewing pattern elements in two Heliconius butterfly co‐mimics. We use quantitative trait locus (QTL) analysis with a multivariate...
British Journal of Cancer, Published online: 17 September 2020; doi:10.1038/s41416-020-01065-3Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1
British Journal of Cancer, Published online: 17 September 2020; doi:10.1038/s41416-020-01058-2Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population
British Journal of Cancer, Published online: 17 September 2020; doi:10.1038/s41416-020-01064-4Prognostic and predictive significance of nuclear HIF1α expression in locally advanced HNSCC patients treated with chemoradiation with or without nimotuzumab
British Journal of Cancer, Published online: 17 September 2020; doi:10.1038/s41416-020-01056-4Breast cancer survival in Nordic BRCA2 mutation carriers—unconventional association with oestrogen receptor status
Related Articles Prognostic significance of 18F-sodium fluoride in newly diagnosed multiple myeloma patients. Am J Nucl Med Mol Imaging. 2020;10(4):151-160 Authors: Zadeh MZ, Seraj SM, Østergaard B, Mimms S, Raynor WY, Aly M, Borja AJ, Arani LS, Gerke O, Werner TJ, Zhuang H, Revheim ME, Abildgaard N, Høilund-Carlsen PF, Alavi A Abstract Focal bone lesions and fractures due to weakened bone are associated with higher morbidity and mortality...
Related Articles Validation of a spatial normalization method using a principal component derived adaptive template for [18F]florbetaben PET. Am J Nucl Med Mol Imaging. 2020;10(4):161-167 Authors: Leuzy A, Heurling K, De Santi S, Bullich S, Hansson O, Lilja J Abstract Quantification may help in the context of amyloid-β positron emission tomography (PET). Quantification typically requires that PET images be spatially normalized, a process that...
Related Articles Altered splenic [89Zr]Zr-rituximab uptake in patients with interstitial lung disease not responding to rituximab: could this indicate a splenic immune-mediated mechanism? Am J Nucl Med Mol Imaging. 2020;10(4):168-177 Authors: Adams H, Meek B, van de Garde EM, van Moorsel CH, Vugts DJ, Keijsers RG, Grutters JC Abstract Rituximab (RTX) for immune-mediated inflammatory disease (IMID) with interstitial pneumonitis (IP) results...
Related Articles One decade of 'Bench-to-Bedside' peptide receptor radionuclide therapy with indigenous [177Lu]Lu-DOTATATE obtained through 'Direct' neutron activation route: lessons learnt including practice evolution in an Indian setting. Am J Nucl Med Mol Imaging. 2020;10(4):178-211 Authors: Basu S, Chakraborty S, Parghane RV, Kamaldeep, Ranade R, Thapa P, Asopa RV, Sonawane G, Nabar S, Shimpi H, Chandak A, Vimalnath KV, Ostwal V, Ramaswamy A, Bhandare M,...
Thyroid, Ahead of Print.
Thyroid, Ahead of Print.
Related Articles Insects in high-elevation streams: life in extreme environments imperiled by climate change. Glob Chang Biol. 2020 Sep 15;: Authors: Birrell JH, Shah AA, Hotaling S, Giersch JJ, Williamson CE, Jacobsen D, Woods HA Abstract Climate change is altering conditions in high-elevation streams worldwide, with largely unknown effects on resident communities of aquatic insects. Here, we review the challenges of climate change for high-elevation...
Surgical Infections, Ahead of Print.
In contrast to the many theoretical studies on the adaptation of plant pathogens to qualitative resistances, few studies have investigated how quantitative resistance selects for increased pathogen aggressiveness. We formulate an integro-differential model with nonlocal effects of mutations to describe the evolutionary epidemiology dynamics of spore-producing pathogens in heterogeneous agricultural environments sharing a well-mixed pool of spores. Parasites reproduce clonally and each strain is characterized...
Here we report the surface interrogation scanning electrochemical microscopy (SI‐SECM) of two electrodeposited manganese‐based electrocatalysts, amorphous MnOx and perovskite CaMnO3, to investigate the manganese oxidation state relating to the oxygen evolution reaction (OER) under neutral conditions. The results indicate the amounts of Mn(III) and Mn(IV) species in MnOx and CaMnO3 depend on potential. A Mn(V) species was identified in both structures during the OER. Time‐delay titration of Mn(V)...
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Cryptococcus gattii is a species that has received more recognition in the recent past as distinct from Cryptococcus neoformans. C gattii is known to cause meningeal disease in both immunocompetent and immunosuppressed hosts. Patients may be clinically asymptomatic until immunosuppressive conditions occur such as corticosteroid treatment or an HIV infection. HIV-associated cryptococcal infections...
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Intravascular large B-cell lymphoma (ILBL) is a rare and difficult to diagnose subtype of large B-cell lymphoma. The most common locations of presentation are in the central nervous system and the skin, but there are reports of other organ involvement. Due to the indolence, nonspecific symptoms, and rarity of the disease, this form of lymphoma is most often diagnosed postmortem. In this article, we...
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Acute myocardial infarction (AMI) is a rare but recognized and potentially serious complication of infective endocarditis (IE). This case describes the challenges surrounding the management of AMI in the setting of septic coronary embolism, brain, spleen, and kidney infarcts due to septic emboli from native mitral valve IE.
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
As Covid-19 cases surged in the United States in March 2020, stay-at-home orders were put in place. Schools closed, and many workers were furloughed, laid off, or told to work from home. With personal movement limited and people confined to their homes, advocates expressed concern about a potential…
Responses to the Covid-19 pandemic by stakeholders throughout the health care ecosystem are contributing to rapid innovation. To support health care delivery today, capital equipment (such as ventilators) and personal protective equipment (such as masks and gowns) are being redesigned to permit…
Tissue clearing technique achieves tissue transparency by reducing light scattering and light absorption. Tissue clearing enables whole‐body and whole‐organ imaging and facilitates the understanding of intact organisms at system‐level. Tissue clearing contributes to the investigation of structure‐function relationships in intact mammalian organs, and opens new avenues for cellular and molecular mapping of intact human organs. Abstract Organisms are inherently three dimensional, thus comprehensive...
The Journal of Antibiotics, Published online: 17 September 2020; doi:10.1038/s41429-020-00365-3Synthesis and biological evaluation of esterified and acylated derivatives of NH2-(AEEA)5-amphotericin B
Abstract The study explored the role of healthcare organisations in Ras Al Khaimah, United Arab Emirates, in improving women’s breast cancer awareness and screening participation in a multi-cultural society. In-depth interviews were conducted with eight representatives from five healthcare organisations involved in breast cancer campaigns in RAK including hospitals, clinics, and universities. The interviews were analysed using thematic analysis. The organisations’ campaigns focused...
Abstract Different patients want to take different roles in the treatment decision-making process; these roles can be classified as passive, collaborative, and active. The aim of this study was to investigate the correlation between decision-making preferences among patients with prostate cancer and personal, disease-related, and structural factors. In four survey studies, we asked 7169 prostate cancer patients about their decision-making preferences using the Control Preferences...
Abstract Background Although immunohistochemistry (IHC) along with molecular tests has been investigated in ameloblastoma for BRAF V600E detection, VE1 IHC has not been studied in odontogenic carcinomas (OCs) and benign mixed epithelial and mesenchymal odontogenic tumours (BMOTs). Here, we performed BRAF V600E mutation analysis, examined the expression pattern of VE1 IHC, and comparatively evaluated the performance of two VE1 antibodies in ameloblastomas, OCs, and BMOTs. Methods BRAF V600E...
Purpose In acute ischemic stroke with unknown time of onset, MR‐based diffusion‐weighted imaging (DWI) and fluid‐attenuated inversion recovery (FLAIR) estimates lesion age to guide intravenous thrombolysis. CT‐based quantitative net water uptake (NWU) may be a potential alternative. The purpose of this study was to directly compare CT‐based NWU to MRI at identifying patients with lesion age <4.5h from symptom onset. Methods 50 acute anterior circulation stroke patients were analyzed with...
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