Integrating Differential Gene Expression Analysis with Perturbagen-Response Signatures May Identify Novel Therapies for Thyroid-Associated Orbitopathy. Transl Vis Sci Technol. 2020 Aug;9(9):39 Authors: Lee JY, Gallo RA, Ledon PJ, Tao W, Tse DT, Pelaez D, Wester ST Abstract Purpose: To evaluate the efficacy of Library of Integrated Network-based Cellular Signatures (LINCS) perturbagen prediction software to identify small molecules that revert...
Sat Sep 12, 2020 07:47
Strategic Initiatives for Veterans with Lung Cancer. Fed Pract. 2020 Aug;37(Suppl 4):S76-S80 Authors: Moghanaki D, Hagan M Abstract Background: Lung cancer is a leading cause of cancer-related mortality among veterans-as well as the US population-despite veterans' access to advanced medical technologies within the Veterans Health Administration (VHA). To improve outcomes, the VHA launched 3 lung cancer treatment initiatives in 2016 and 2017....
Sat Sep 12, 2020 07:47
Prostate Cancer Foundation-Department of Veterans Affairs Partnership: A Model of Public-Private Collaboration to Advance Treatment and Care of Invasive Cancers. Fed Pract. 2020 Aug;37(Suppl 4):S32-S37 Authors: Levine RD, Ekanayake RN, Martin AC, Dickson K, McGarrell K, Miyahira A, Campbell RS, Johnson T, Soule HR, Simons JW Abstract Background: Prostate cancer is the most frequently diagnosed and treated cancer in the US Department of Veterans...
Sat Sep 12, 2020 07:47
[Mesenchymal stromal/stem cell therapy for acute graft versus host disease: the next step]. Rinsho Ketsueki. 2020;61(8):953-958 Authors: Miura Y, Fujii S Abstract Expanded human bone marrow-derived mesenchymal stromal/stem cells (MSC) have been used in the treatment of acute graft-versus-host disease (GVHD). It is currently accepted that the use of allogeneic off-the-shelf MSC has therapeutic efficacy with no apparent serious early-onset adverse...
Sat Sep 12, 2020 07:47
Loss of FBXW7-mediated degradation of BRAF elicits resistance to BET inhibitors in adult T cell leukemia cells. Mol Cancer. 2020 09 09;19(1):139 Authors: Yeh CH, Bellon M, Wang F, Zhang H, Fu L, Nicot C Abstract BACKGROUND: Human T cell leukemia virus type 1 (HTLV-1)-associated adult T cell leukemia (ATL) has a very poor prognosis with a median survival of 8 months and a 4-year overall survival of 11% for acute ATL. Present treatment options...
Sat Sep 12, 2020 07:47
[Seventy years of development and prospects of the ocular oncology specialty in China]. Zhonghua Yan Ke Za Zhi. 2020 Sep 11;56(9):646-652 Authors: Fan XQ, Jia RB Abstract Ocular tumors include intraocular tumors and tumors of the eyelid, orbit, conjunctiva and lacrimal apparatus. After seventy years of continued growth, ocular oncology in China, from small to large and from weak to strong, has made great achievements. Especially since the beginning...
Sat Sep 12, 2020 07:47
CCAAT/Enhancer-Binding Protein Delta (C/EBPδ): A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells. Cancers (Basel). 2020 Sep 07;12(9): Authors: Hartl L, Duitman J, Aberson HL, Chen K, Dijk F, Roelofs JJTH, Dings MPG, Hooijer GKJ, Hernanda PY, Pan Q, Busch OR, Besselink MGH, Boerman T, Peppelenbosch MP, Bijlsma MF, Spek CA Abstract CCAAT/enhancer-binding protein δ (C/EBPδ)...
Sat Sep 12, 2020 07:47
Related Articles Hairy cell leukemia: present and future directions. Leuk Lymphoma. 2019 12;60(12):2869-2879 Authors: Kreitman RJ Abstract Hairy cell leukemia (HCL) is an indolent B-cell malignancy, with long-term responses to purine analogs, but with decreasing efficacy and increasing toxicity with repeated courses. Leukemic cells express CD22, CD20, CD25, tartrate-resistant acid phosphatase (TRAP), annexin 1A (Anxa1), and BRAF V600E mutation....
Sat Sep 12, 2020 07:47
Related Articles Self-Assembling Peptide-Based Multifunctional Nanofibers for Electrochemical Identification of Breast Cancer Stem-like Cells. Anal Chem. 2019 06 18;91(12):7531-7537 Authors: Tang Y, Dai Y, Huang X, Li L, Han B, Cao Y, Zhao J Abstract Cancer stem-like cells are closely related with the development and metastasis of tumors. Herein, an electrochemical method is proposed to identify stem-like cells in breast tumor. The core concept...
Sat Sep 12, 2020 07:47
Bone development in transgender adolescents treated with GnRH analogues and subsequently gender affirming hormones. J Clin Endocrinol Metab. 2020 Sep 10;: Authors: Schagen SEE, Wouters FM, Cohen-Kettenis PT, Gooren LJ, Hannema SE Abstract CONTEXT: Hormonal interventions in adolescents with gender dysphoria may have adverse effects such as reduced bone mineral accrual. OBJECTIVE: To describe bone mass development in adolescents with...
Sat Sep 12, 2020 07:37
Inhalable functional mixed-polymer microspheres to enhance doxorubicin release behavior for lung cancer treatment. Colloids Surf B Biointerfaces. 2020 Sep 01;196:111350 Authors: Li W, Chen S, Zhang L, Zhang Y, Yang X, Xie B, Guo J, He Y, Wang C Abstract Porous poly(cyclohexane-1,4-diyl acetone dimethylene ketal) (PCADK)/poly(d,l-lactide-co-glycolide) (PLGA) mixed-matrix porous microspheres loaded with doxorubicin (Dox) were successfully prepared,...
Sat Sep 12, 2020 07:33
Synthesis, biological evaluation and molecular docking studies of novel thiopyrimidine analogue as apoptotic agent with potential anticancer activity. Bioorg Chem. 2020 Sep 01;104:104249 Authors: Haffez H, Taha H, Rabie MA, Awad SM, Zohny YM Abstract This study synthesizes novel 6-amino-5-cyano-4-aryl-2-mercapto pyrimidines and condensed pyrimidines analogues in order to investigate their potential activity as anticancer agents. The compounds...
Sat Sep 12, 2020 07:33
Mechanisms underlying dimethyl sulfoxide-induced cellular migration in human normal hepatic cells. Environ Toxicol Pharmacol. 2020 Sep 07;:103489 Authors: Wei F, Zhao L, Jing Y Abstract Numerous studies have reported that low-dose dimethyl sulfoxide (DMSO, <1.5%, v/v) can interfere with various cellular processes, such as cell proliferation, differentiation, apoptosis, and cycle. By contrast, minimal information is available about the effect...
Sat Sep 12, 2020 07:33
Characterization of SPK 98, a Torin2 analog, as ATR and mTOR dual kinase inhibitor. Bioorg Med Chem Lett. 2020 Sep 07;:127517 Authors: Bhakuni R, Shaik A, Priya B, Kirubakaran S Abstract A series of Torin2, a second-generation ATP-competitive inhibitor, analogues were biologically characterized to identify their potential for ATR and mTOR kinase inhibition. Compound SPK 98 was observed to inhibit ATR/mTOR kinase selectively over ATM kinase...
Sat Sep 12, 2020 07:33
Exploring the radiosensitizing potential of AZD8931: a pilot study on the human LoVo colorectal cancer cell line. Int J Radiat Biol. 2020 Sep 10;:1-22 Authors: Antognelli C, Palumbo I, Piattoni S, Calzuola M, Del Papa B, Talesa VN, Aristei C Abstract Aim: To explore the radiosensitizing effect of AZD8931, a novel equipotent and reversible inhibitor of signalling by EGFR (HER1), HER2 and HER3 receptors, focusing on cell cycle progression, apoptosis...
Sat Sep 12, 2020 07:33
Axenic in-vitro cultivation of nineteen peat-moss (Sphagnum L.) species as a resource for basic biology, biotechnology and paludiculture. New Phytol. 2020 Sep 10;: Authors: Heck MA, Lüth VM, van Gessel N, Krebs M, Kohl M, Prager A, Joosten H, Decker EL, Reski R Abstract Sphagnum farming can substitute peat with renewable biomass and thus help mitigate climate change. Large volumes of required founder material can only be supplied sustainably...
Sat Sep 12, 2020 07:33
Limiting homologous recombination at stalled replication forks is essential for cell viability: DNA2 to the rescue. Curr Genet. 2020 Sep 09;: Authors: Appanah R, Jones D, Falquet B, Rass U Abstract The disease-associated nuclease-helicase DNA2 has been implicated in DNA end-resection during DNA double-strand break repair, Okazaki fragment processing, and the recovery of stalled DNA replication forks (RFs). Its role in Okazaki fragment...
Sat Sep 12, 2020 07:33
THAP11 Functions as a Tumor Suppressor in Gastric Cancer through Regulating c-Myc Signaling Pathways. Biomed Res Int. 2020;2020:7838924 Authors: Zhang J, Zhang H, Shi H, Wang F, Du J, Wang Y, Wei Y, Xue W, Li D, Feng Y, Yan J, Gao Y, Li J, Han J Abstract We aim to investigate the role of THAP11 (thanatos-associated protein11) in gastric cancer and its regulation mechanisms. THAP11 expression was analyzed in 51 pairs of GC tissues and the...
Sat Sep 12, 2020 07:33
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma. Oncogenesis. 2020 Sep 10;9(9):80 Authors: Gibson AE, Yeung C, Issaq SH, Collins VJ, Gouzoulis M, Zhang Y, Ji J, Mendoza A, Heske CM Abstract NAMPT mediates the rate-limiting step of the NAD salvage pathway, which maintains cellular bioenergetics and provides a necessary...
Sat Sep 12, 2020 07:33
8-Chloro-Adenosine Inhibits Proliferation of MDA-MB-231 and SK-BR-3 Breast Cancer Cells by Regulating ADAR1/p53 Signaling Pathway. Cell Transplant. 2020 Jan-Dec;29:963689720958656 Authors: Ding HY, Yang WY, Zhang LH, Li L, Xie F, Li HY, Chen XY, Tu Z, Li Y, Chen Y, Yang SY Abstract 8-Chloro-adenosine (8-Cl-Ado) has been shown to exhibit its antitumor activity by inducing apoptosis in human lung cancer A549 and H1299 cells or autophagy...
Sat Sep 12, 2020 07:33
Related Articles βKlotho is identified as a target for theranostics in non-small cell lung cancer. Theranostics. 2019;9(25):7474-7489 Authors: Li F, Li X, Li Z, Ji W, Lu S, Xia W Abstract Non-small cell lung cancer (NSCLC) remains a great challenge, calling for the identification of novel molecular targets with diagnostic/therapeutic value. Here, we sought to characterize the expression of βKlotho and its anti-tumor roles in NSCLC. Methods:...
Sat Sep 12, 2020 07:33
Related Articles The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity. Cell Rep. 2019 Sep 17;28(12):3182-3198.e11 Authors: Papoutsoglou P, Tsubakihara Y, Caja L, Morén A, Pallis P, Ameur A, Heldin CH, Moustakas A Abstract Molecular processes involving lncRNAs regulate cell function. By applying transcriptomics, we identify lncRNAs whose expression is regulated by transforming growth factor β (TGF-β). Upon silencing...
Sat Sep 12, 2020 07:33
Related Articles Goat and buffalo milk fat globule membranes exhibit better effects at inducing apoptosis and reduction the viability of HT-29 cells. Sci Rep. 2019 02 22;9(1):2577 Authors: Ji X, Xu W, Cui J, Ma Y, Zhou S Abstract Bovine milk fat globule membrane (MFGM) has shown many health benefits, however, there has not been much study on non-cattle MFGMs. The purpose of this study was to compare the anti-proliferation effects and investigate...
Sat Sep 12, 2020 07:33
Related Articles Emerging Frontiers in Microbiome Engineering. Trends Immunol. 2019 10;40(10):952-973 Authors: Inda ME, Broset E, Lu TK, de la Fuente-Nunez C Abstract The gut microbiome has a significant impact on health and disease and can actively contribute to obesity, diabetes, inflammatory bowel disease, cardiovascular disease, and neurological disorders. We do not yet have the necessary tools to fine-tune the microbial communities that...
Sat Sep 12, 2020 07:32
[Development of Auditory Processing and Perception Skills with and without APD in Primary School Age]. Laryngorhinootologie. 2020 Sep 10;: Authors: Nickisch A, Nickisch L, Kiese-Himmel C Abstract BACKGROUND: We examined two student age groups (1st and 4th class) in a control-group comparison whether the maturation processes of the central hearing system in typically developing children are also present in children with Central Auditory Processing...
Sat Sep 12, 2020 07:28
Selfish chromosomal drive shapes recent centromeric histone evolution in monkeyflowers [NEW RESULTS]
Under the selfish centromere model, costs associated with female meiotic drive by centromeres select on interacting kinetochore proteins to restore Mendelian inheritance. We directly test this model in yellow monkeyflowers (Mimulus guttatus), which are polymorphic for a costly driving centromere (D). We show that the D haplotype is structurally and genetically distinct and swept to a high stable frequency within the past 1500 years. Quantitative genetic analyses reveal that variation in the strength...
Fri Sep 11, 2020 03:00
Cells may be able to promote adaptive evolution in a gene-specific and temporally-controlled manner. Genes encoded on the lagging strand have a higher mutation rate and evolve faster than genes on the leading strand. This effect is likely driven by head-on replication-transcription conflicts, which occur when lagging strand genes are transcribed during DNA replication. We previously suggested that the ability to selectively increase mutagenesis in a subset of genes may provide an adaptive advantage...
Fri Sep 11, 2020 03:00
Effects of Total Red Meat Intake on Glycemic Control and Inflammatory Biomarkers: A Meta-Analysis of Randomized Controlled Trials. Adv Nutr. 2020 Sep 10;: Authors: O'Connor LE, Kim JE, Clark CM, Zhu W, Campbell WW Abstract Our objective was to conduct a systematic review and meta-analysis to assess the effects of total red meat (TRM) intake on glycemic control and inflammatory biomarkers using randomized controlled trials of individuals free...
Sat Sep 12, 2020 07:25
Prognostic Potential of the Preoperative Controlling Nutritional Status (CONUT) Score in Predicting Survival of Patients with Cancer: A Systematic Review. Adv Nutr. 2020 Sep 10;: Authors: Kheirouri S, Alizadeh M Abstract The nutritional status of a patient has prognostic potency concerning short- and long-term outcomes, including survival, in many diseases. The controlling nutritional status (CONUT) score is a method for assessing nutritional...
Sat Sep 12, 2020 07:25
Modified Suturing Techniques in Carotid Endarterectomy for Reducing the Cerebral Ischemic Time. J Korean Neurosurg Soc. 2020 Sep 10;: Authors: Joo SP, Cho YH, Lee YJ, Kim YS, Kim TS Abstract Objective: Carotid endarterectomy (CEA) is an effective surgical procedure for treating symptomatic or asymptomatic patients with carotid stenosis. Many neurosurgeons use a shunt to reduce perioperative ischemic complications. However, the use of shunting...
Sat Sep 12, 2020 07:22
Association of serum Apolipoprotein B with cerebrospinal fluid biomarkers of Alzheimer's pathology. Ann Clin Transl Neurol. 2020 Sep 10;: Authors: Hu H, Tan L, Bi YL, Xu W, Tan L, Shen XN, Hou XH, Ma YH, Dong Q, Yu JT Abstract OBJECTIVE: To examine whether apolipoprotein B (ApoB), apolipoprotein A-1 (ApoA1), or their ratio (ApoB/A1) were associated with early changes in cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) pathology...
Sat Sep 12, 2020 07:21
[From reconstruction to function : Hands-on training in tympanoplasty using real-time feedback]. HNO. 2020 Sep 10;: Authors: Beleites T, Zahnert T, Polk ML, Kluge A, Neudert M, Kemper M Abstract BACKGROUND: Surgery of the middle ear requires a very high level of fine motor skills. Due to the increased potential for complications in middle ear operations, it is appropriate to acquire these skills beforehand by operating on a model. ...
Sat Sep 12, 2020 07:19
[Robot-assisted head and neck surgery]. HNO. 2020 Sep 10;: Authors: Schuler PJ, Boehm F, Schild LR, Greve J, Hoffmann TK Abstract Robot-assisted surgery (RAS) has already been approved for several clinical applications in head and neck surgery. In some Anglo-American regions, RAS is currently the common standard for treatment of oropharyngeal diseases. Systematic randomized studies comparing established surgical procedures with RAS in a large...
Sat Sep 12, 2020 07:19
[Neutrophils in the tumor microenvironment-foes or friends?] HNO. 2020 Sep 10;: Authors: Jablonska J, Rist M, Lang S, Brandau S Abstract Neutrophils are the most abundant white blood cells in the human circulation and are usually associated with inflammation and with fighting infections. In recent years, the role of these cells during cancer progression has been a matter of increasing interest. Tumor-associated neutrophils (TANs) accumulate...
Sat Sep 12, 2020 07:19
Fungal infections in dentistry: clinical presentations, diagnosis, and treatment alternatives. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Aug 18;: Authors: Lombardi A, Ouanounou A Abstract Oral candidiasis is a common opportunistic infection that requires knowledge of the various clinical presentations and management strategies for successful treatment. Numerous local and systemic factors contribute to the development of candidiasis,...
Sat Sep 12, 2020 07:19
The flavonoid 6-hydroxyflavone prevention of cisplatin-induced nephrotoxicity. Histol Histopathol. 2020 Sep 10;:18251 Authors: Ud Din Z, Farooq SU, Shahid M, Alghamdi O, Al-Hamoudi N, Vohra F, Abduljabbar T Abstract In this study, the flavonoid, 6-hydroxyflavone was investigated for its renal protective activity in the cisplatin rat model of nephrotoxicity. Male Sprague-Dawley rats weighing 200-250 g were included in the study. 6-Hydroxyflavone...
Sat Sep 12, 2020 07:19
The original version of this article contained errors in Table 3 on page 6.
Sat Sep 12, 2020 03:00
17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "BMJ Open"[jour] These pubmed results were generated on 2020/09/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Sep 12, 2020 07:15
Changes in self-reported sleep duration with age - a 36-year longitudinal study of Finnish adults. BMC Public Health. 2020 Sep 09;20(1):1373 Authors: Hublin C, Haasio L, Kaprio J Abstract BACKGROUND: Sleep deprivation is often claimed to be increasingly common, but most studies show small changes in sleep duration over the last decades. Our aim was to analyze long-term patterns in self-reported sleep duration in a population-based cohort. ...
Sat Sep 12, 2020 07:14
The frequencies and disparities of adverse childhood experiences in the U.S. BMC Public Health. 2020 Sep 10;20(1):1327 Authors: Giano Z, Wheeler DL, Hubach RD Abstract BACKGROUND: Adversity experienced during childhood manifests deleteriously across the lifespan. This study provides updated frequency estimates of ACEs using the most comprehensive and geographically diverse sample to date. METHODS: ACEs data were collected via BRFSS...
Sat Sep 12, 2020 07:14
Towards achieving the 90-90-90 HIV targets: results from the south African 2017 national HIV survey.
Towards achieving the 90-90-90 HIV targets: results from the south African 2017 national HIV survey. BMC Public Health. 2020 Sep 09;20(1):1375 Authors: Marinda E, Simbayi L, Zuma K, Zungu N, Moyo S, Kondlo L, Jooste S, Nadol P, Igumbor E, Dietrich C, Briggs-Hagen M Abstract BACKGROUND: Measuring progress towards the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 treatment targets is key to assessing progress towards turning the...
Sat Sep 12, 2020 07:14
Impact of quadrivalent influenza vaccines in Brazil: a cost-effectiveness analysis using an influenza transmission model. BMC Public Health. 2020 Sep 09;20(1):1374 Authors: Crépey P, Boiron L, Araujo RR, Lopez JG, Petitjean A, de Albuquerque Luna EJ Abstract BACKGROUND: Influenza epidemics significantly weight on the Brazilian healthcare system and its society. Public health authorities have progressively expanded recommendations for vaccination...
Sat Sep 12, 2020 07:14
Topical Triamcinolone on "Sweet Spots" to Block Dynamic Pain after Tonsillectomy and Uvulo-Palato-Pharyngo-Plasty. Ann Otol Rhinol Laryngol. 2020 Sep 10;:3489420953602 Authors: Chen JK, Niddam DM, Tung TH, Li LP Abstract OBJECTIVES: Severe pain on swallowing (or dynamic pain) has long been a problem in patients receiving tonsillectomy and uvulopalatopharyngoplasty for the treatment of obstructive sleep apnea syndrome and/or snoring. We...
Sat Sep 12, 2020 07:14
Patient-Reported Factors Associated with the Onset of Hyperfunctional Voice Disorders. Ann Otol Rhinol Laryngol. 2020 Sep 10;:3489420956379 Authors: Kridgen S, Hillman RE, Stadelman-Cohen T, Zeitels S, Burns JA, Hron T, Krusemark C, Muise J, Van Stan JH Abstract OBJECTIVES: Prevention, diagnosis, and treatment of hyperfunctional voice disorders would be improved by better understanding their etiological contributing factors. Therefore,...
Sat Sep 12, 2020 07:14
Nowadays, biological dosimetry performed by cytogenetic, is the gold standard to estimate the absorbed ionizing radiation (IR)-dose [1], being useful for doses over 0.1 Gy and specific for IR-exposure. However, in an emergency scenario, the 46 h that lymphocytes require to achieve the first metaphase to perform the analysis, become disadvantageous. This complexity increases when there are many victims simultaneously. A promising strategy to estimate the absorbed dose, accelerating the analysis of...
Fri Sep 11, 2020 03:00
26 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2020/09/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Sep 12, 2020 07:08
The non-selective adenosine antagonist theophylline reverses the effects of dopamine antagonism on tremor, motor activity and effort-based decision-making. Pharmacol Biochem Behav. 2020 Sep 07;:173035 Authors: Pardo M, Paul NE, Collins-Praino LE, Salamone JD, Correa M Abstract Considerable evidence indicates that adenosine and dopamine systems interact in the regulation of basal ganglia function. Nonselective adenosine antagonists such as the...
Sat Sep 12, 2020 07:06
Does palliative resection of primary tumor in stage IV colorectal cancer improve survival? An invited commentary on"Survival outcome of palliative primary tumor resection for colorectal cancer patients with synchronous liver and/or lung metastases: A retrospective cohort study in the SEER database by propensity score matching analysis". Int J Surg. 2020 Sep 07;: Authors: Liu X, Mei Z PMID: 32911121 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 07:01
Spontaneous Intraparenchymal Tension Pneumocephalus. J Neurol Surg A Cent Eur Neurosurg. 2020 Sep 10;: Authors: Seo H, Kim SH, Ryu J, Lee SH Abstract Tension pneumocephalus is a treatable emergency that is usually caused by trauma or surgery. We present a rare case of spontaneous tension pneumocephalus. A 64-year-old woman presented with a severe aggravating headache. Computed tomography revealed a large air collection in the brain parenchyma...
Sat Sep 12, 2020 06:58
Role of Tropomyosin-related kinase B receptor and brain-derived neurotrophic factor in cancer. Cytokine. 2020 Sep 07;136:155270 Authors: Serafim Junior V, Fernandes GMM, Oliveira-Cucolo JG, Pavarino EC, Goloni-Bertollo EM Abstract The tropomyosin-related kinase B (TrkB) receptor is a member of the neurotrophic tyrosine kinase receptors family and, together with the brain-derived neurotrophic factor (BDNF), plays an important role in the development...
Sat Sep 12, 2020 06:58
Minimally invasive and inexpensive percutaneous abscess drainage using an indwelling needle cannula.
Minimally invasive and inexpensive percutaneous abscess drainage using an indwelling needle cannula. Am J Otolaryngol. 2020 Aug 12;41(6):102664 Authors: Tanaka K, Tsunoda A, Tou M, Sonoda K, Arai S, Anzai T, Matsumoto F Abstract PURPOSE: Abscess is still a formidable disease and requires adequate drainage. Moreover, drainage in the head and neck area needs cosmetic care, especially in the pediatric population. In this report, we introduce our...
Sat Sep 12, 2020 06:58
Deep learning-based metal artifact reduction using cycle-consistent adversarial network for intensity-modulated head and neck radiation therapy treatment planning. Phys Med. 2020 Sep 07;78:8-14 Authors: Koike Y, Anetai Y, Takegawa H, Ohira S, Nakamura S, Tanigawa N Abstract PURPOSE: To develop a deep learning-based metal artifact reduction (DL-MAR) method using unpaired data and to evaluate its dosimetric impact in head and neck intensity-modulated...
Sat Sep 12, 2020 06:58
Crosstalk between RNA m6A Modification and Non-coding RNA Contributes to Cancer Growth and Progression. Mol Ther Nucleic Acids. 2020 Aug 08;22:62-71 Authors: Dai F, Wu Y, Lu Y, An C, Zheng X, Dai L, Guo Y, Zhang L, Li H, Xu W, Gao W Abstract N6-methyladenosine (m6A) is the most common RNA modification and has an important role in normal development and tumorigenesis. The abnormal expression of m6A regulators can lead to an imbalance in m6A...
Sat Sep 12, 2020 06:58
The effectiveness of a preoperative multi-component non-pharmacologic preparation on post-tonsillectomy pain: A randomized controlled clinical trial. Int J Pediatr Otorhinolaryngol. 2020 Sep 01;138:110359 Authors: Faramarzi M, Roosta S, Faramarzi A, Salehi A, Matani N Abstract INTRODUCTION: Tonsillectomy is a painful operation and some studies have suggested that preoperative non-pharmacologic preparations may decrease postoperative pain. In...
Sat Sep 12, 2020 06:58
Diagnostic considerations prior to pediatric tracheocutaneous fistula closure. Int J Pediatr Otorhinolaryngol. 2020 Sep 01;138:110357 Authors: Chorney SR, Husain S, Sobol SE Abstract INTRODUCTION: An airway assessment often occurs prior to tracheocutaneous fistula (TCF) closure in children. Bronchoscopy (MLB) with or without fistula-occluded polysomnography (PSG) helps determine candidacy and localize potential obstruction. To date, little...
Sat Sep 12, 2020 06:58
Biofilm distribution on tympanostomy tubes: An ex vivo descriptive study. Int J Pediatr Otorhinolaryngol. 2020 Sep 03;138:110350 Authors: Habashi N, Marom T, Steinberg D, Zacks B, Tamir SO Abstract BACKGROUND: Tympanostomy tube (TT) insertion is a common procedure in children with otitis media with effusion. Post-TT otorrhea (PTTO) is a frequent post-operative complication. Biofilms are involved in chronic PTTO cases. OBJECTIVE: To...
Sat Sep 12, 2020 06:58
Exploring the utility of fibreoptic endoscopic evaluation of swallowing in young children- A comparison with videofluoroscopy. Int J Pediatr Otorhinolaryngol. 2020 Aug 29;138:110339 Authors: Pavithran J, Puthiyottil IV, Kumar M, Nikitha AV, Vidyadharan S, Bhaskaran R, Chandrababu Jaya A, Thankappan K, Subramania I, Sundaram KR Abstract OBJECTIVES/HYPOTHESIS: In adults, fibreoptic endoscopic evaluation of swallowing (FEES) has established its...
Sat Sep 12, 2020 06:58
Brain necrosis in adult patients after proton therapy: Is there evidence for dependency on linear energy transfer (LET)? Int J Radiat Oncol Biol Phys. 2020 Sep 07;: Authors: Niemierko A, Schuemann J, Niyazi M, Giantsoudi D, Maquilan G, Shih HA, Paganetti H Abstract PURPOSE: To investigate if radiographic imaging changes defined as necrosis correlate with regions in the brain with elevated linear energy transfer (LET) for proton radiation therapy...
Sat Sep 12, 2020 06:58
In vitro evaluation of poly (vinyl alcohol)/collagen blended hydrogels for regulating human periodontal ligament fibroblasts and gingival fibroblasts. Int J Biol Macromol. 2020 Sep 07;: Authors: Zhou T, Zheng K, Sui B, Boccaccini AR, Sun J Abstract Periodontitis is a chronic inflammatory disease that can destroy periodontal tissue. Guided tissue regeneration (GTR) is widely applied to treat periodontitis. However, the challenge is to develop...
Sat Sep 12, 2020 06:58
Validation of a Novel Wearable Electromyography Patch for Monitoring Submental Muscle Activity During Swallowing: A Randomized Crossover Trial. J Speech Lang Hear Res. 2020 Sep 10;:1-18 Authors: Kantarcigil C, Kim MK, Chang T, Craig BA, Smith A, Lee CH, Malandraki GA Abstract Purpose Surface electromyography (sEMG) is often used for biofeedback during swallowing rehabilitation. However, commercially available sEMG electrodes are not optimized...
Sat Sep 12, 2020 06:58
Continuous Versus 1-Year Fixed-Duration Nivolumab in Previously Treated Advanced Non-Small-Cell Lung Cancer: CheckMate 153. J Clin Oncol. 2020 Sep 10;:JCO2000131 Authors: Waterhouse DM, Garon EB, Chandler J, McCleod M, Hussein M, Jotte R, Horn L, Daniel DB, Keogh G, Creelan B, Einhorn LH, Baker J, Kasbari S, Nikolinakos P, Babu S, Couture F, Leighl NB, Reynolds C, Blumenschein G, Gunuganti V, Li A, Aanur N, Spigel DR Abstract PURPOSE: Limited...
Sat Sep 12, 2020 06:58
Prophylactic Fixation and Arthroscopic Bone Grafting of Large Femoral Neck Cyst During Hip Labral Repair and Femoral Osteochondroplasty: A Case Report. JBJS Case Connect. 2020 Jul-Sep;10(3):e2000120 Authors: Plaster S, Fine R, Ockuly A, Richter D Abstract CASE: We describe a case of hip impingement in an 18-year-old woman in association with a large cyst at the femoral neck equal to a resection level of approximately 40%. There was great concern...
Sat Sep 12, 2020 06:58
Prevalence of Human Papillomavirus 6 and 11 variants in recurrent respiratory papillomatosis. J Med Virol. 2020 Sep 10;: Authors: Sichero L, Ferreira S, López RVM, Mello BP, Costa V, El-Achkar VNR, Carlos R, Ribeiro-Silva A, Pignatari S, Kaminagakura E, Villa LL Abstract Human papillomavirus (HPV) types 6 and 11 are the etiological agents of recurrent respiratory papillomatosis (RRP). We examined the prevalence and distribution of HPVs 6 and...
Sat Sep 12, 2020 06:58
Mother with child (1921): a Graves' disease painted by Otto Dix. J Endocrinol Invest. 2020 Sep 10;: Authors: Accorona R, Guastella C, Pignataro L PMID: 32910410 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 06:58
Hearing loss and cognitive decline in the general population: a prospective cohort study. J Neurol. 2020 Sep 10;: Authors: Croll PH, Vinke EJ, Armstrong NM, Licher S, Vernooij MW, Baatenburg de Jong RJ, Goedegebure A, Ikram MA Abstract BACKGROUND: Previous studies identifying hearing loss as a promising modifiable risk factor for cognitive decline mostly adjusted for baseline age solely. As such a faster cognitive decline at a higher age, which...
Sat Sep 12, 2020 06:58
Augmented reality with HoloLens in parotid surgery: how to assess and to improve accuracy. Eur Arch Otorhinolaryngol. 2020 Sep 10;: Authors: Scherl C, Stratemeier J, Karle C, Rotter N, Hesser J, Huber L, Dias A, Hoffmann O, Riffel P, Schoenberg SO, Schell A, Lammert A, Affolter A, Männle D Abstract PURPOSE: Augmented reality improves planning and execution of surgical procedures. The aim of this study was to evaluate the feasibility of a 3D...
Sat Sep 12, 2020 06:58
COVID-19, Disparities, and Opportunities for Equity in Otolaryngology-Unequal America. JAMA Otolaryngol Head Neck Surg. 2020 Sep 10;: Authors: Burks CA, Ortega G, Bergmark RW PMID: 32910198 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 06:58
Association of Hypertension With the Risk and Severity of Epistaxis. JAMA Otolaryngol Head Neck Surg. 2020 Sep 10;: Authors: Byun H, Chung JH, Lee SH, Ryu J, Kim C, Shin JH Abstract Importance: The association between hypertension and epistaxis has long been a subject of debate. Objectives: To evaluate the risk of epistaxis in patients with hypertension using a nationwide population cohort and to assess the association of hypertension...
Sat Sep 12, 2020 06:58
Sinonasal Teratocarcinosarcoma-A Rare and Highly Aggressive Neoplasm. JAMA Otolaryngol Head Neck Surg. 2020 Sep 10;: Authors: Miller M, Newberry CI, Witt B, Oakley GM PMID: 32910178 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 06:58
Oral Health in Medicare: Considerations for 21st-Century Coverage. JAMA. 2020 Sep 10;: Authors: Leinbach LI, Willink A PMID: 32910164 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 06:58
Incomplete Picture of Otolaryngologist Performance in the Merit-Based Incentive Payment System-Reply. JAMA Otolaryngol Head Neck Surg. 2020 Sep 10;: Authors: Xiao R, Varvares MA, Rathi VK PMID: 32910161 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 06:58
Spontaneous Cerebrospinal Fluid Leak in a Transgender Man: Is Testosterone Therapy a Risk Factor? JAMA Otolaryngol Head Neck Surg. 2020 Sep 10;: Authors: Lin GC, Paz M, Porrmann JW, Scharf R, Benitez RP, Moshel YA PMID: 32910142 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 06:58
Technology Can Augment, but Not Replace, Critical Human Skills Needed for Patient Care. Acad Med. 2020 Sep 08;: Authors: Alrassi J, Katsufrakis PJ, Chandran L Abstract The practice of medicine is changing rapidly as a consequence of electronic health record adoption, new technologies for patient care, disruptive innovations that breakdown professional hierarchies, and evolving societal norms. Collectively, these have resulted in the modification...
Sat Sep 12, 2020 06:58
Tracheal Diverticulum: Rare Presentation of Known Entity: A Case Report. A A Pract. 2020 Jul;14(9):e01262 Authors: Chakraborty A, Vaish R, Chatterjee A, Sable N, Chaukar D Abstract Paratracheal air cyst encompasses conditions including tracheoceles, bronchogenic cysts, lymphoepithelial cysts, and tracheal diverticula. The occurrence of tracheal diverticulum is rare and usually does not manifest clinically or may cause symptoms like chronic...
Sat Sep 12, 2020 06:58
Behind the Mask. J Gen Intern Med. 2020 Sep 09;: Authors: Deschler DG PMID: 32909228 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 06:58
Clinical characteristics in unilateral vestibular atelectasis. J Neurol. 2020 Sep 09;: Authors: Marc M, Hautefort C, Guichard JP, Herman P, Houdart E, Toupet M, Eliezer M Abstract INTRODUCTION: Unilateral vestibular atelectasis (UVA), an entity first described by Merchant and Schuknecht in 1988, has rarely been reported in vivo as of yet. We specify here the clinical characteristics of 22 patients diagnosed with UVA. MATERIALS...
Sat Sep 12, 2020 06:58
Content validity evidence for a simulation-based test of handheld otoscopy skills. Eur Arch Otorhinolaryngol. 2020 Sep 09;: Authors: von Buchwald JH, Frendø M, Guldager MJ, Melchiors J, Andersen SAW Abstract PURPOSE: At graduation from medical school, competency in otoscopy is often insufficient. Simulation-based training can be used to improve technical skills, but the suitability of the training model and assessment must be supported...
Sat Sep 12, 2020 06:58
Effect of head position on cochlear implant MRI artifact. Eur Arch Otorhinolaryngol. 2020 Sep 09;: Authors: Ay N, Gehl HB, Sudhoff H, Todt I Abstract PURPOSE: A new generation of cochlear implant (CI) magnets and specific surgical techniques (e.g., implant positioning) has changed the relationship between a CI and magnet resonance imaging (MRI). MRI allows a pain free in vivo evaluation of the inner ear fluid state and internal auditory...
Sat Sep 12, 2020 06:58
Anosmia: an evolution of our understanding of its importance in COVID-19 and what questions remain to be answered. Eur Arch Otorhinolaryngol. 2020 Sep 09;: Authors: Saussez S, Lechien JR, Hopkins C Abstract BACKGROUND: From the start of the pandemic, many European otolaryngologists observed an unprecendented number of anosmic patients. Early reports proposed that anosmia could be the first or even the only symptom of COVID-19 infection,...
Sat Sep 12, 2020 06:58
Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection. Biomed Res Int. 2020;2020:3964518 Authors: Olmos-Zuñiga JR, Baltazares-Lipp M, Hernández-Jiménez C, Jasso-Victoria R, Gaxiola-Gaxiola M, Silva-Martínez M, Iñiguez-García MA, González-González AI, Vázquez-Minero JC, Luna-Flores A, Solis-Alanis N, Baltazares-Lipp ME Abstract Treatment of tracheal...
Sat Sep 12, 2020 06:58
Outcome and Complications of Frontal Sinus Stenting: A Case Presentation and Literature Review. Case Rep Otolaryngol. 2020;2020:8885870 Authors: Khan MA, Alshareef WA, Marglani OA, Herzallah IR Abstract Introduction: Frontal sinus surgery remains challenging to manage because of its complex anatomy and narrow outflow tract. A number of studies suggest the success of frontal sinus stenting to reduce postoperative complications in endoscopic...
Sat Sep 12, 2020 06:58
Diffuse Spontaneous Laryngeal Hemorrhage with Trastuzumab. Case Rep Otolaryngol. 2020;2020:8818905 Authors: Klute L, Solverson M, Bingcang CM, Dowdall JR Abstract Drug-induced epithelial hemorrhage of the endolarynx is an unusual etiology of hemoptysis. We present a case of hemoptysis in a young female patient undergoing treatment for metastatic breast cancer with trastuzumab emtansine. Though previously associated with diffuse spontaneous...
Sat Sep 12, 2020 06:58
Middle Ear Salivary Choristoma: A Rare Case Report and Update on Congenital Associations, Facial Nerve Involvement, and Treatment Strategies. Case Rep Otolaryngol. 2020;2020:8435140 Authors: Young A, Evans L, Ng M Abstract Salivary gland choristoma is an extremely rare middle ear mass and is hypothesized to be caused by second branchial arch developmental anomalies. We present a 14-year-old girl with Dandy-Walker syndrome and conductive...
Sat Sep 12, 2020 06:58
Metal-Working Fluids Exposure and a Rare Frontoethmoid Lesion. Case Rep Otolaryngol. 2020;2020:3148125 Authors: Shahidi S, Nassimizadeh A, Sandison A, Ahmed S Abstract This case report describes a unique nasal mass that was difficult to diagnose clinically and histologically. The patient was a middle-aged man employed as a metalworker, and he presented with a unilateral nasal obstruction and a mass arising from the right middle meatus....
Sat Sep 12, 2020 06:58
A New Therapy for Vitiligo Using Fire Needles: A Systematic Review of Evidence from 3618 Subjects. Evid Based Complement Alternat Med. 2020;2020:8492097 Authors: Luo Y, Qian W, Dai T, Ru Y, Sun X, Kuai L, Liu L, Xing M, Zheng Q, Zhang Y, Chen X, Zhao H, Li B, Li X Abstract Introduction: Fire needle therapy has been reported as an effective treatment for vitiligo. However, current clinical evidence has not been systematically evaluated....
Sat Sep 12, 2020 06:58
Human Papillomavirus Prevalence in Oral and Oropharyngeal Rinse and Gargle Specimens of Dental Patients and of an HIV-Positive Cohort from Pretoria, South Africa. Adv Virol. 2020;2020:2395219 Authors: Wood NH, Makua KS, Lebelo RL, Redzic N, Benoy I, Vanderveken OM, Bogers J Abstract Introduction: Studies on HPV prevalence in the head and neck region of South Africans are sparse. Of the available reports in the literature, there were no...
Sat Sep 12, 2020 06:58
Targeted Next-Generation Sequencing Identifies Separate Causes of Hearing Loss in One Deaf Family and Variable Clinical Manifestations for the p.R161C Mutation in SOX10. Neural Plast. 2020;2020:8860837 Authors: Yu X, Lin Y, Wu H Abstract Hearing loss is the most common sensory deficit in humans. Identifying the genetic cause and genotype-phenotype correlation of hearing loss is sometimes challenging due to extensive clinical and genetic...
Sat Sep 12, 2020 06:58
Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy. Neural Plast. 2020;2020:8843485 Authors: Feng B, Jin C, Cheng Z, Zhao X, Sun Z, Zheng X, Li X, Dong T, Tao Y, Wu H Abstract Sensorineural hearing loss (SNHL) becomes an inevitable worldwide public health issue, and deafness treatment is urgently imperative; yet their current curative therapy is limited. Auditory neuropathies (AN) were proved to play a substantial...
Sat Sep 12, 2020 06:58
Catecholamine signaling that modulates cerebellar operations in cognition. Neuropsychopharmacology. 2020 Sep 09;: Authors: Fujita H, Carlson ES PMID: 32908243 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 06:58
Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion. Nat Commun. 2020 Sep 09;11(1):4520 Authors: Peng DH, Rodriguez BL, Diao L, Chen L, Wang J, Byers LA, Wei Y, Chapman HA, Yamauchi M, Behrens C, Raso G, Soto LMS, Cuentes ERP, Wistuba II, Kurie JM, Gibbons DL Abstract Tumor extracellular matrix has been associated with drug resistance and immune suppression. Here, proteomic and RNA profiling...
Sat Sep 12, 2020 06:58
Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation. J Immunother Cancer. 2020 Sep;8(2): Authors: Cassetta L, Bruderek K, Skrzeczynska-Moncznik J, Osiecka O, Hu X, Rundgren IM, Lin A, Santegoets K, Horzum U, Godinho-Santos A, Zelinskyy G, Garcia-Tellez T, Bjelica S, Taciak B, Kittang AO, Höing B, Lang S, Dixon M, Müller V, Utikal JS, Karakoç D, Yilmaz KB, Górka E, Bodnar L, Anastasiou OE, Bourgeois...
Sat Sep 12, 2020 06:58
Trotter's triad. BMJ Case Rep. 2020 Sep 08;13(9): Authors: Sakthivel P, Mohamed A, Guwariya M, Chirom AS PMID: 32907871 [PubMed - in process]
Sat Sep 12, 2020 06:58
Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea. Development. 2020 Sep 09;: Authors: Huarcaya Najarro E, Huang J, Jacobo A, Quiruz LA, Grillet N, Cheng AG Abstract Planar cell polarity (PCP) proteins localize asymmetrically to instruct cell polarity within the tissue plane, with defects leading to deformities of the limbs, neural tube, and inner ear. Wnt proteins are evolutionarily conserved...
Sat Sep 12, 2020 06:58
Combined application of single-energy metal artifact reduction and reconstruction techniques in patients with Cochlear implants. J Otolaryngol Head Neck Surg. 2020 Sep 09;49(1):65 Authors: Wei F, Li J, Zhou C, Li Y, Wang X, Huang B, Sun Q, Xiong G Abstract BACKGROUND: The purpose of this study was to develop an effective method of reducing metal artifacts in cochlear implant (CI) electrodes. METHODS: The temporal bones of 30...
Sat Sep 12, 2020 06:58
Maximum and Minimum Phonatory Glottal Area before and after Treatment for Vocal Nodules. Healthcare (Basel). 2020 Sep 07;8(3): Authors: Hsu CM, Yang MY, Fang TJ, Wu CY, Tsai YT, Chang GH, Tsai MS Abstract Background: Vocal fold nodules (VFNs) are a challenge for otolaryngologists. Glottal area (GA) waveform analysis is an examination method used for assessing vocal fold vibration and function. However, GA in patients with VFNs has rarely...
Sat Sep 12, 2020 06:58
Related Articles The Reply. Am J Med. 2020 07;133(7):e383 Authors: Lisan Q, Empana JP PMID: 32600548 [PubMed - indexed for MEDLINE]
Sat Sep 12, 2020 06:58
Related Articles The diagnostic value of detecting sudden smell loss among asymptomatic COVID-19 patients in early stage: The possible early sign of COVID-19. Auris Nasus Larynx. 2020 Aug;47(4):565-573 Authors: Kang YJ, Cho JH, Lee MH, Kim YJ, Park CS Abstract IMPORTANCE: The newly emerged coronavirus disease 19 (COVID-19), is threatening the world. Olfactory or gustatory dysfunction is reported as one of the symptoms worldwide. As reported...
Sat Sep 12, 2020 06:58
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