This paper describes AI-Toolbox, a C++ software library that contains reinforcement learning and planning algorithms, and supports both single and multi agent problems, as well as partial observability. It is designed for simplicity and clarity, and contains extensive documentation of its API and code. It supports Python to enable users not comfortable with C++ to take advantage of the library's speed and functionality. AI-Toolbox is free software, and is hosted online at https://github.com/Svalorzen/AI-Toolbox.
Wed Jan 01, 2020 02:00
This work is concerned with the non-negative rank-1 robust principal component analysis (RPCA), where the goal is to recover the dominant non-negative principal components of a data matrix precisely, where a number of measurements could be grossly corrupted with sparse and arbitrary large noise. Most of the known techniques for solving the RPCA rely on convex relaxation methods by lifting the problem to a higher dimension, which significantly increase the number of variables. As an alternative, the...
Wed Jan 01, 2020 02:00
Gaussian belief propagation (GaBP) is a message-passing algorithm that can be used to perform approximate inference on a pairwise Markov graph (MG) constructed from a multivariate Gaussian distribution in canonical parameterization. The output of GaBP is a set of approximate univariate marginals for each variable in the pairwise MG. An extension of GaBP (labeled GaBP-m), allowing for the approximation of higher-dimensional marginal distributions, was explored by Kamper et al. (2019). The idea is...
Wed Jan 01, 2020 02:00
Co-training is a well-known semi-supervised learning approach which trains classifiers on two or more different views and exchanges pseudo labels of unlabeled instances in an iterative way. During the co-training process, pseudo labels of unlabeled instances are very likely to be false especially in the initial training, while the standard co-training algorithm adopts a 'draw without replacement' strategy and does not remove these wrongly labeled instances from training stages. Besides, most of the...
Wed Jan 01, 2020 02:00
Latent variable models allow capturing the hidden structure underlying the data. In particular, feature allocation models represent each observation by a linear combination of latent variables. These models are often used to make predictions either for new observations or for missing information in the original data, as well as to perform exploratory data analysis. Although there is an extensive literature on latent feature allocation models for homogeneous datasets, where all the attributes that...
Wed Jan 01, 2020 02:00
Regularized least-squares (kernel-ridge / Gaussian process) regression is a fundamental algorithm of statistics and machine learning. Because generic algorithms for the exact solution have cubic complexity in the number of datapoints, large datasets require to resort to approximations. In this work, the computation of the least-squares prediction is itself treated as a probabilistic inference problem. We propose a structured Gaussian regression model on the kernel function that uses projections of...
Wed Jan 01, 2020 02:00
The gold standard for discovering causal relations is by means of experimentation. Over the last decades, alternative methods have been proposed that can infer causal relations between variables from certain statistical patterns in purely observational data. We introduce Joint Causal Inference (JCI), a novel approach to causal discovery from multiple data sets from different contexts that elegantly unifies both approaches. JCI is a causal modeling framework rather than a specific algorithm, and it...
Wed Jan 01, 2020 02:00
Motivated by modern applications in which one constructs graphical models based on a very large number of features, this paper introduces a new class of cluster-based graphical models, in which variable clustering is applied as an initial step for reducing the dimension of the feature space. We employ model assisted clustering, in which the clusters contain features that are similar to the same unobserved latent variable. Two different cluster-based Gaussian graphical models are considered: the latent...
Wed Jan 01, 2020 02:00
We propose and analyze a novel theoretical and algorithmic framework for structured prediction. While so far the term has referred to discrete output spaces, here we consider more general settings, such as manifolds or spaces of probability measures. We define structured prediction as a problem where the output space lacks a vectorial structure. We identify and study a large class of loss functions that implicitly defines a suitable geometry on the problem. The latter is the key to develop an algorithmic...
Wed Jan 01, 2020 02:00
In this paper we introduce a statistical model, called additively faithful directed acyclic graph (AFDAG), for causal learning from observational data. Our approach is based on additive conditional independence (ACI), a recently proposed three-way statistical relation that shares many similarities with conditional independence but without resorting to multi-dimensional kernels. This distinct feature strikes a balance between a parametric model and a fully nonparametric model, which makes the proposed...
Wed Jan 01, 2020 02:00
In short-term portfolio optimization (SPO), some financial characteristics like the expected return and the true covariance might be dynamic. Then there are only a small window size $w$ of observations that are sufficiently close to the current moment and reliable to make estimations. $w$ is usually much smaller than the number of assets $d$, which leads to a typical undersampled problem. Worse still, the asset price relatives are not likely subject to any proper distributions. These facts violate...
Wed Jan 01, 2020 02:00
We present a theoretical analysis framework for relational ensemble models. We show that ensembles of collective classifiers can improve predictions for graph data by reducing errors due to variance in both learning and inference. In addition, we propose a relational ensemble framework that combines a relational ensemble learning approach with a relational ensemble inference approach for collective classification. The proposed ensemble techniques are applicable for both single and multiple graph...
Wed Jan 01, 2020 02:00
pyDML is an open-source python library that provides a wide range of distance metric learning algorithms. Distance metric learning can be useful to improve similarity learning algorithms, such as the nearest neighbors classifier, and also has other applications, like dimensionality reduction. The pyDML package currently provides more than 20 algorithms, which can be categorized, according to their purpose, in: dimensionality reduction algorithms, algorithms to improve nearest neighbors or nearest...
Wed Jan 01, 2020 02:00
We develop ancestral Gumbel-Top-$k$ sampling: a generic and efficient method for sampling without replacement from discrete-valued Bayesian networks, which includes multivariate discrete distributions, Markov chains and sequence models. The method uses an extension of the Gumbel-Max trick to sample without replacement by finding the top $k$ of perturbed log-probabilities among all possible configurations of a Bayesian network. Despite the exponentially large domain, the algorithm has a complexity...
Wed Jan 01, 2020 02:00
Cornac is an open-source Python framework for multimodal recommender systems. In addition to core utilities for accessing, building, evaluating, and comparing recommender models, Cornac is distinctive in putting emphasis on recommendation models that leverage auxiliary information in the form of a social network, item textual descriptions, product images, etc. Such multimodal auxiliary data supplement user-item interactions (e.g., ratings, clicks), which tend to be sparse in practice. To facilitate...
Wed Jan 01, 2020 02:00
Precise genetic manipulation of specific cell types or tissues to pinpoint gene function requirement is a critical step in studies aimed at unraveling the intricacies of organismal physiology. Drosophila researchers heavily rely on the UAS/Gal4/Gal80 system for tissue-specific manipulations; however, it is often unclear whether the reported Gal4 expression patterns are indeed specific to the tissue of interest such that experimental results are not confounded by secondary sites of Gal4 expression....
Sat Sep 12, 2020 01:09
The wels catfish (Silurus glanis) is one of the largest freshwater fish species in the world. This top predator plays a key role in ecosystem stability, and represents an iconic trophy-fish for recreational fishermen. S. glanis is also a highly valued species for its high-quality boneless flesh, and has been cultivated for over 100 years in Eastern and Central Europe. The interest in rearing S. glanis continues to grow; the aquaculture production of this species has almost doubled during the last...
Sat Sep 12, 2020 01:09
Background: Prostate-specific membrane antigen (PSMA)-ligand positron-emission-tomography (PSMA-PET) is potentially useful for screening of castration resistant prostate cancer (CRPC) clinical trial target populations. Aim: We investigated the impact of PSMA-PET on Prostate Cancer Clinical Trials Working Group 3 (PCWG3) clinical subtype classification when compared to conventional imaging (CI). Methods: Multicenter retrospective study enrolling patients with (a) PSMA-PET for CRPC, (b) PSA values...
Fri Sep 11, 2020 23:48
Fri Sep 11, 2020 23:48
The goal of this study was to develop an 89Zr-labeled anti-PD-L1 immune PET technique that can quantitatively monitor chemotherapy-mediated modulation of tumor PD-L1 expression in living subjects. Methods: Anti-PD-L1 antibodies underwent sulfohydryl moiety-specific conjugation with maleimide-deferoxamine (DFO) followed by 89Zr radiolabeling. 89Zr-PD-L1 IgG was evaluated for radiochemical purity, specific activity and radiolabel stability. Parental CT26 colon cancer cells and CT26/PD-L1 cells engineered...
Fri Sep 11, 2020 23:48
Determination of structure of RNA via NMR is complicated in large part by the lack of a precise parameterization linking the observed chemical shifts to the underlying geometric parameters. In contrast to proteins, where numerous high-resolution crystal structures serve as coordinate templates for this mapping, such models are rarely available for smaller oligonucleotides accessible via NMR, or they exhibit crystal packing and counter-ion binding artifacts that prevent their use for the chemical...
Fri Sep 11, 2020 20:05
We explored how tabersonine (Tab) protected against dexamethasone (Dex)-induced osteoporosis. Osteoblasts were treated with Dex (100 µM) with or without Table (5 or 10 µM). We measured cell viability, alkaline...
Fri Sep 11, 2020 03:00
The activator protein-1 (AP-1) family of transcription factors modulate a diverse range of cellular signalling pathways into outputs which can be oncogenic or anti-oncogenic. The transcription of relevant gene...
Fri Sep 11, 2020 03:00
Purpose: New therapies have changed the outlook for patients with multiple myeloma, but novel agents are needed for patients who are refractory or relapsed on currently approved drug classes. Novel targets other than CD38 and BCMA are needed for new immunotherapy development, as resistance to daratumumab and emerging anti-BCMA approaches appears inevitable. One potential target of interest in myeloma is ICAM1. Naked anti-ICAM1 antibodies were active in preclinical models of myeloma and safe in patients,...
Fri Sep 11, 2020 15:43
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07666
Fri Sep 11, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06370
Fri Sep 11, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07580
Fri Sep 11, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08599
Fri Sep 11, 2020 07:00
Facial Plast SurgDOI: 10.1055/s-0040-1715621Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Full text
Fri Sep 11, 2020 02:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02374
Fri Sep 11, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01857
Fri Sep 11, 2020 07:00
This case report presents a case of a patient with global cerebral infarction of uncertain etiology following an emergency surgery for acute type A aortic dissection. As a result, factor XII deficiency was rev...
Fri Sep 11, 2020 03:00
Abstract Objectives To evaluate and compare the effects of different surface conditioning methods of lithium disilicate–reinforced ceramic on shear bond strength (SBS) of metallic brackets. Materials and methods Thirty-six lithium disilicate ceramic blocks mounted in acrylic resin blocks were assigned to 3 groups (n = 12): 9.6% hydrofluoric acid (HF); neodymium-doped...
Fri Sep 11, 2020 03:00
Abstract Objectives This study aimed to investigate whether combined exposure to starch and sucrose modifies the activity of carbonic anhydrase VI (CA VI) in saliva (Study 1) and biofilm (Study 2) of children with early childhood caries (ECC). Material and methods For Study 1 and Study 2, respectively, 54 and 46 preschoolers aged 4 to 5 were allocated into...
Fri Sep 11, 2020 03:00
Abstract Purpose Natural Killer (NK) cells are a vital part of immune surveillance and have been implicated in colorectal cancer development and prognosis. This systematic review aims to distil the literature on NK cells as it relates to colorectal cancer. Methods All published studies over 10 years relating to NK cells and colorectal cancer were reviewed....
Fri Sep 11, 2020 03:00
Extracorporeal membrane oxygenation (ECMO) has evolved considerably over the past two decades and has been gradually utilized in severe trauma. However, the indications for the use of ECMO in trauma remain unc...
Fri Sep 11, 2020 03:00
The genes regulating pluripotent stem cells in mammals are surprisingly similar across 48 species, researchers report. The study also shows that differences among these 'gene regulating networks' might explain how certain features of mammalian pluripotent stem cells have evolved.
Tue Sep 08, 2020 18:33
Autism spectrum disorder (ASD) is a clinical spectrum of neurodevelopment disorder characterized by deficits in social communication and social interaction along with repetitive/stereotyped behaviors. The current diagnosis for autism relies entirely on clinical evaluation and has many limitations. In this study, we aim to elucidate the potential mechanism behind autism and establish a series of potential biomarkers for diagnosis. Here, we established an ultra-high-performance liquid chromatography-quadrupole...
Fri Sep 11, 2020 16:50
A survey has shown that audiologists feel the COVID-19 lockdown has brought about some beneficial changes to the care of patients with hearing problems.Dr. Gabrielle Saunders, a Senior Research Fellow at The University of Manchester says findings from the survey of 140 audiologists are a rare positive in the crisis which has caused misery across the world.The study, published in the International Journal of Audiology, estimates that between 29 May and 15 June, just 5% of face to face audiology appointments...
Fri Sep 11, 2020 12:33
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction if it is not timely diagnosed and treated. This happens probably following a cascade of immune reactions after the administration of the drug ultimately leading to multiorgan failure and death. Several groups of drugs have been identified as potential aetiologies but the commonest one identified is antiepileptic drugs. The clinical features of DRESS syndrome usually appear several weeks...
Fri Sep 11, 2020 18:35
A new study has furthered our understanding of plant evolution by tracking the origins of electrical signaling components that plants developed to communicate and adapt to life on land.
Thu Sep 03, 2020 20:30
The normal aging process affects many human functions profoundly. The voice is no exception, and some aging effects on the voice are obvious including vocal fold atrophy, bowing, stiffness, more prominent vocal fold processes, and glottic insufficiency. The study's primary aim was to determine the correlation between presbylarynx and laryngeal electromyography (LEMG) results and to compare these electromyography (EMG) results with young and old voice patients without evidence of presbylarynx changes...
Fri Sep 11, 2020 03:00
To investigate how adipose-derived mesenchymal stem cells (ADSCs), secreted hepatocyte growth factor (HGF), and basic fibroblast growth factor (bFGF) affect the fibroblast phenotype after vocal fold injury.
Fri Sep 11, 2020 03:00
Sabha MushtaqJournal of Cutaneous and Aesthetic Surgery 2020 13(3):255-256The razor blade has been used by dermatologists as an alternative tool for performing shave excision and biopsy owing to its superior sharpness and flexibility. It is inexpensive and freely available but the bare blade design carries the risk of accidental injury to the operator and patient. We describe an easy modification of the razor blade for better grip, control, and safety in obtaining cutaneous shave specimens.
Fri Sep 11, 2020 00:00
Lloyd Steele, Alistair Brown, Fangyi XieJournal of Cutaneous and Aesthetic Surgery 2020 13(3):191-196Multiple techniques for skin graft fixation have been proposed, but the evidence underlying these techniques is unclear. This study aimed to review the literature for full-thickness graft fixation techniques. PubMed was electronically searched to identify relevant studies. The search strategy identified 91 relevant articles. These consisted of 2 randomised controlled trials (RCTs), 10 observational...
Fri Sep 11, 2020 00:00
Rakhi Issrani, Namdeo Prabhu, Mohammad Khurseed AlamJournal of Cutaneous and Aesthetic Surgery 2020 13(3):240-242A detailed history and complete clinical examination of the patient with the soft tissue injury are needed to identify and diagnose the most probable underlying cause of that specific injury. The presented case is of a chemical burn due to formocresol, presenting with moderate pain and burning sensation with respect to a patch of darkly discolored skin. This case is reported because of...
Fri Sep 11, 2020 00:00
Fatima T Zahra, Mohammad Adil, Syed S Amin, Mohd Mohtashim, Roopal Bansal, Hania Q KhanJournal of Cutaneous and Aesthetic Surgery 2020 13(3):197-203Background: Vitiligo is a chronic disease of great cosmetic concern presenting with depigmented macules and patches. It is often recalcitrant to medical treatment. Aim: The aim of the study was to study the efficacy and safety of topical 5% 5-fluorouracil with needling versus topical 5% 5-fluorouracil alone in stable vitiligo. Materials and Methods: This...
Fri Sep 11, 2020 00:00
Hina Jajoria, Aniketh Venkataram, Venkataram MysoreJournal of Cutaneous and Aesthetic Surgery 2020 13(3):185-190Knowledge of facial anatomy is indispensable for dermatologists and plastic surgeons practicing aesthetic medicine, especially for those using fillers, as injection of fillers may be associated with serious complications such as vascular occlusion and blindness. Angiosome and choke vessels play an important role in vascular incidents occurring after filler injections. The objective of this...
Fri Sep 11, 2020 00:00
Anand Lamoria, Aditi Agrawal, Pankaj Rao, Dilip KachhawaJournal of Cutaneous and Aesthetic Surgery 2020 13(3):204-209Introduction: Several modalities are currently available for the treatment of vitiligo, but generally they do not result in complete cure of the disease. Despite the limitations and some side effects, surgical modalities appear to be the method of choice in recalcitrant stable vitiligo. Both Jodhpur technique (JT) and follicular unit transplantation (FUT) are simpler and cheaper methods,...
Fri Sep 11, 2020 00:00
Pradipkumar R Atodaria, Kuldeepsinh P AtodariaJournal of Cutaneous and Aesthetic Surgery 2020 13(3):247-250In hair transplantation, recipient-site creation is an important step. It is a repetitive and time-consuming step, which increased the “out-of-body time” for the grafts, which could hamper their survival. To solve this problem, we had devised an instrument called the Multi Slit Knife (MSK). The MSK has advantages of creating a high-density brick pattern of recipient sites in significantly less...
Fri Sep 11, 2020 00:00
Dipty A Agrawal, Niti KhungerJournal of Cutaneous and Aesthetic Surgery 2020 13(3):210-216Background: Scarring is one of the most dreadful complications of acne for which patients seek surgical treatment. Objective: The aim of this research was to study the morphological features of acne scarring and the relationship between severity of acne and its treatment with type and severity of acne scars. Materials and Methods: This was a hospital-based, noninterventional, cross-sectional study carried out...
Fri Sep 11, 2020 00:00
Jenny Mathew, Simin Muhammed KuttyJournal of Cutaneous and Aesthetic Surgery 2020 13(3):259-260
Fri Sep 11, 2020 00:00
Surabhi R Kolte, Vidyadhar R SardesaiJournal of Cutaneous and Aesthetic Surgery 2020 13(3):217-221Context: Warts constitute 21% of all the cases in a dermatology clinic. Their causative agent is the human papillomavirus (HPV). Most of the cutaneous warts are cosmetically disfiguring and their treatment requires patience by both the practitioner and the patients. Aim: This study aimed to compare the efficacy of intralesional measles, mumps, rubella (MMR) vaccine and needling in the treatment of recurrent...
Fri Sep 11, 2020 00:00
Nabeel K AlhamzawiJournal of Cutaneous and Aesthetic Surgery 2020 13(3):237-239Hair transplantation is considered safe compared to other cosmetic procedures. However, scarring is still an inevitable potential complication. Keloid scarring is a rare complication of hair transplantation and usually associated with strip harvesting rather than follicular unit extraction (FUE). A case of keloids at the donor site following FUE hair transplantation is presented. Hair transplant practitioners should be...
Fri Sep 11, 2020 00:00
Padmalakshmi Bharathi Mohan, Uday Kumar Chapa, Ravi Kumar Chittoria, Vinayak Chavan, Abhinav Aggarwal, Saurabh Gupta, Chirra Likhitha Reddy, Imran Pathan, Shijina KoliyathJournal of Cutaneous and Aesthetic Surgery 2020 13(3):222-225Of the complications of diabetes mellitus, foot ulcers are the most dreaded complications, as they can progress at an alarming rate and can be very difficult to treat. Various modalities have been described in the treatment of diabetic foot ulcers. One such modality of...
Fri Sep 11, 2020 00:00
Sumit Gupta, Priyanka Borde Bisht, Charisma KannanJournal of Cutaneous and Aesthetic Surgery 2020 13(3):243-246The Plasma Bio-Filler Facelift is an exciting aesthetic process being introduced in dermatology. The dermal filler gel is autologous and easy to obtain. It works well for fine rhytides reduction as well as to volumize, contour and rejuvenate the face, neck and hands. The consistency and autologous nature of plasma bio-filler are better accepted by patients than the high density hyaluronic...
Fri Sep 11, 2020 00:00
Amir Feily, Ahmad Feily, Jacob S Alexander, Muhammad J Niaz, Serena Gianfaldoni, Torello Lotti, Marigdalia K Ramirez-FortJournal of Cutaneous and Aesthetic Surgery 2020 13(3):226-228Hair transplantation in areas of scalp scars is a clinical challenge. However, by creating the visual illusion of central bulking with the use of peripherally transplanted curled chest hairs, cicatricial alopecia can perhaps be cosmetically improved. In a case of a 34-year-old affected man, this strategic procedure was...
Fri Sep 11, 2020 00:00
Azize Kilic, Ali Kilic, Ali E Kivanc, Abdullah SisikJournal of Cutaneous and Aesthetic Surgery 2020 13(3):251-254Skin biopsies provide physicians with valuable information in the evaluation of many dermatologic diseases. It becomes increasingly important for physicians to be proficient at performing skin biopsies because of the prevalence of skin malignancies and other dermatologic diseases in general population. The most common techniques include the punch, shave, excisional, and incisional biopsies....
Fri Sep 11, 2020 00:00
Anjuna Reghunath, Rohini G Ghasi, Suchana KushvahaJournal of Cutaneous and Aesthetic Surgery 2020 13(3):229-232Cystic hygroma is a congenital malformation of the lymphatic system that mostly presents at birth. Though the classic treatment of this condition is surgical excision, recent alternative treatment modalities such as injection of sclerotherapeutic agents (e.g., bleomycin and OK-432) into the lesion has gained popularity due to its safe and effective response profile with minimal side effects....
Fri Sep 11, 2020 00:00
Danielle P Dubin, Ethan T Routt, Matthew J Lin, Richard L Torbeck, Hooman KhorasaniJournal of Cutaneous and Aesthetic Surgery 2020 13(3):257-258Full-thickness skin grafts harvested from hair-bearing areas may negatively impact cosmetic outcomes if the recipient site is hairless. Intraoperative depilation of unwanted hair follicles using an electrosurgical device can permanently remove hair with a single treatment and improve overall cosmesis.
Fri Sep 11, 2020 00:00
Karishma Tahlan, Nadeem Tanveer, Harresh Kumar, Himanshi DiwanJournal of Cutaneous and Aesthetic Surgery 2020 13(3):233-236Glial heterotopias are the displacement of neuroglial tissue in extracranial sites. Nasal glial heterotopias can be of three types-extranasal, intranasal and mixed. Root of the nose is the most common location. These are rare anomalies with an incidence of 1 case in 20,000–40,000 live births. Here we report the case of a 6-month-old infant with a congenital mass located at the...
Fri Sep 11, 2020 00:00
Mohd Altaf Mir, Madhubari Vathulya, Sameer Mahakalkar, Nishank ManoharJournal of Cutaneous and Aesthetic Surgery 2020 13(3):261-263Acquired digital fibrokeratoma is an uncommon, benign fibrous tumor that usually occurs in adults as a solitary lesion with a typical size of less than 1 cm. We present a case with periungual growth and nail plate deformity. The growth was completely excised after raising the epinychial flap and the fold was reconstructed. The histological results confirmed the digital...
Fri Sep 11, 2020 00:00
Head and neck oncology post-treatment consultations form a critical component of care in terms of support and surveillance. They occur frequently in the first few years and can place substantial demands on healthcare resources. However, they provide useful opportunities for patients to raise issues and receive tailored information and support. The aim of this paper was to assess whether completion of a 56-item patient prompt list (PCI - the Patient Concerns Inventory) immediately prior to the consultation...
Fri Sep 11, 2020 03:00
Robotic surgery has become more common in otolaryngologic surgery since the introduction of the da Vinci robotic system, but has played a limited role in anterior and central skull base surgery, largely because of technical limitations of existing robots. Current robotic technology has been used in creative ways to access the skull base, but was not designed to navigate these complex anatomic constraints. Novel robots should target many of the limitations of current robotic technology, such as maneuverability,...
Fri Sep 11, 2020 03:00
ABSTRACT Purpose Impaired olfactory function is one of the main features of Parkinson’s disease. However, how peripheral olfactory structures are involved remains unclear. Using diffusion tensor imaging fiber tracking, we investigated for MRI microstructural changes in the parkinsonian peripheral olfactory system and particularly the olfactory tract, in order to seek a better understanding of the structural alternations underlying hyposmia...
Fri Sep 11, 2020 03:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07810
Fri Sep 11, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04335
Fri Sep 11, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08032
Fri Sep 11, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04387
Fri Sep 11, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06044
Fri Sep 11, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02591
Fri Sep 11, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02688
Fri Sep 11, 2020 07:00
Abstract Objectives To explore the pathophysiology of proliferative verrucous leukoplakia, a rare oral disorder that exhibits high rates of recurrence and malignant transformation, through a RNAseq case-control study. Material and methods We obtained oral biopsies from 10 patients with verrucous leukoplakia lesions and from the mucosa of 5 healthy individuals...
Fri Sep 11, 2020 03:00
Sex dimorphisms are widespread in animals and plants, for morphological as well as physiological traits. Understanding the genetic basis of sex dimorphism and its evolution is crucial for understanding biological differences between the sexes. Genetic variants with sex-antagonistic effects on fitness are expected to segregate in populations at the early phases of sexual dimorphism emergence. Detecting such variants is notoriously difficult, and the few genome-scan methods employed so far have limited...
Fri Sep 11, 2020 03:00
We are in the midst of new developments in the Association for the Anthropology of Policy (ASAP). And, as the times demand, we are thinking anew about how we share our work and meet one another as a section. Last fall, at the 2020 American Anthropological Association (AAA) Annual Meeting in Vancouver we focused our sights on a retrospective look at ASAP’s intellectual history, its future directions, and on the influence of scholars such as critical geographer Jamie Peck and cultural studies theorist...
Fri Sep 11, 2020 22:00
The mayor of the City of Boise was clearly not prepared to receive a Pendleton. This type of blanket, used across contemporary Native North America to honor the receiver, is typically folded and draped around the receiver’s shoulders. Mayor Bieter would have had little reason to know this protocol, given the pervasive erasure of Native people in Southwestern Idaho, both in presence and in memory. Since forced removal in 1869, the descendants of the Shoshone and Paiute bands who used to call the...
Fri Sep 11, 2020 21:40
The field of phylogeography has evolved rapidly in terms of the analytical toolkit to analyze the ever-increasing amounts of genomic data. Despite substantial advances, researchers have not fully explored all potential analytical tools to tackle the challenge posed by the huge size of genomic datasets. For example, deep learning techniques, such as convolutional neural networks (CNNs), widely employed in image and video classification, are largely unexplored for phylogeographic model selection. In...
Sun Sep 13, 2020 03:00
Abstract Merkel cell carcinoma is most commonly seen in the skin of sun exposed areas, particularly the head and neck and is associated with Merkel cell polyomavirus. Merkel cell carcinoma at an extracutaneous mucosal site of the head and neck is rare. We report a case of a 74-year-old women who presented with an enlarging thyroid mass found to be neuroendocrine carcinoma consistent with Merkel cell carcinoma (positive for synaptophysin, chromogranin, CK20). Subsequent work up...
Fri Sep 11, 2020 03:00
Exposome encompasses all human environmental exposures from conception onwards. The impact of environmental exposures is greatest in critical stages of life including fetal and early childhood. Birth cohorts provide a good study setting to assess exposome in the sensitive periods of life. Here, we review birth cohorts with an exposomic approach, their key outcomes and challenges.
Fri Sep 11, 2020 03:00
After a decade conducting research on interrelated themes of citizen journalism, digital activism, and political trolling, I have embarked on a new field: an ethnography of cryptocurrency circles in Turkey. Although I was aware of cryptocurrencies, and particularly Bitcoin, I have noticed how it also became an everyday phenomenon thanks to my roommate Mesut. Mesut, a Kurdish migrant from the southeastern part of Turkey, had no official identification number due to some complicated financial issues....
Fri Sep 11, 2020 21:20
Invoking a sentiment of social responsibility towards oneself, one’s family, and the entire nation, the Prime Minister of India last March announced what was initially supposed to be a 21-day COVID-19 lockdown (the duration of the lockdown was later extended). He urged all Indians to “stay at home, do just one thing… stay at home.” Shortly after this announcement was made, news channels broadcast videos and images of millions of migrant laborers with their families emptying out of cities and walking...
Fri Sep 11, 2020 21:04
Usually the first steps in dealing with a pandemic are identifying the microbial pathogen, how it infects us, and how it moves globally from one host to another, before ultimately calculating the pathogen virulence and mortality rate of the host. A pandemic initially has one dimension, the biomedical or epidemiological dimension. However, as soon as we try to understand the pathogen’s global spread and its differential virulence and mortality, we also start discovering new dimensions of the pandemic....
Fri Sep 11, 2020 21:02
The precariousness of urban life is brought into full perspective by those who are otherwise invisible. As the coronavirus spread across the United States this past spring, New York City became the epicenter of the global pandemic. At the heart of the epicenter was Jackson Heights in the borough of Queens, said to be the most diverse neighborhood in the country, where some 167 languages are spoken. The majority of the neighborhood’s impoverished working masses—many immigrating from Latin America...
Fri Sep 11, 2020 21:00
Publication date: Available online 10 September 2020Source: Clinical TherapeuticsAuthor(s): Cong Ma, Yinxia Zhao, Zhiwen Liu
Fri Sep 11, 2020 21:26
Publication date: Available online 10 September 2020Source: Clinical TherapeuticsAuthor(s): Hae-Young Lee, Ki-Hoon Han, Woo-Baek Chung, Sung-Ho Her, Tae-Ho Park, Seung-Woon Rha, So-Yeon Choi, Kyung-Tae Jung, Jong-Seon Park, Pum-Joon Kim, Jong-Min Lee, Myung-Ho Jeong, Eun-Seok Shin, Hyeon-Cheol Gwon, Kyoo-Rok Han, Jei-Keon Chae, Woo-Shik Kim, Dong-Ju Choi, Bum-Kee Hong, Si-Wan Choi
Fri Sep 11, 2020 21:26
Abstract Purpose Anti-Müllerian hormone (AMH) levels fall during pregnancy but the amount of time required for AMH levels to return to normal has not been accurately determined. We have previously shown that AMH levels have yet to return to normal in some women at 3-months postpartum. In this study, AMH levels were examined at 1- and 5-months postpartum to examine whether AMH levels had returned to normal within this interval. ...
Fri Sep 11, 2020 03:00
Publication date: Available online 10 September 2020Source: Hearing ResearchAuthor(s): Jennifer Krizman, Silvia Bonacina, Nina Kraus
Fri Sep 11, 2020 20:54
Publication date: Available online 10 September 2020Source: Hearing ResearchAuthor(s): Mathilde de Kerangal, Deborah Vickers, Maria Chait
Fri Sep 11, 2020 20:54
Publication date: Available online 10 September 2020Source: Hearing ResearchAuthor(s): Manuel S. Malmierca, Ryszard Auksztulewicz
Fri Sep 11, 2020 20:54
Abstract Faithful tumor mouse models are fundamental research tools to advance the field of immuno-oncology (IO). This is particularly relevant in diseases with low incidence, as in the case of pediatric malignancies, that rely on pre-clinical therapeutic development. However, conventional syngeneic and genetically engineered mouse models fail to recapitulate the tumor heterogeneity and microenvironmental complexity of human pathology that are essential determinants of cancer-directed...
Fri Sep 11, 2020 03:00
Publication date: Available online 11 September 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Jennifer E Kettle, Zoe Marshman, Lindsay Winchester, Lauren Hardwick, Robert Bolt, Nicolas Lee
Fri Sep 11, 2020 20:36
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Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.