Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Sclerosing extramedullary hematopoietic tumor (SEMHT) is a rare disease that was originally named fibrous hematopoietic tumor or myelosclerosis. The process typically occurs in patients with a history of chronic myeloproliferative disorders and may afflict the skin, lung, breast, gastrointestinal tract, breast, kidney, lymph node, and thyroid gland. In this article, we report the case of a 37-year-old...
Fri Sep 11, 2020 09:12
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Coronavirus disease 2019 (COVID-19) caused by a novel human coronavirus has led to a tsunami of viral illness across the globe, originating from Wuhan, China. Although the value and effectiveness of extracorporeal membrane oxygenation (ECMO) in severe respiratory illness from COVID-19 remains unclear at this time, there is emerging evidence suggesting that it could be utilized as an ultimate treatment...
Fri Sep 11, 2020 09:12
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Supine orthostatic hypertension with orthostatic hypotension is an autonomic dysfunction where the patients present with hypertension when supine and with decrease in blood pressure while bearing an upright posture. We report on a 74-year-old male who was admitted with dizziness and was found to have profound orthostatic hypotension with supine hypertension. The patient also developed orthostatic...
Fri Sep 11, 2020 09:11
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. The purpose of this work was to extract key players such as mRNAs and long non-coding RNA (lncRNAs) in the etiopathogenesis of osteosarcoma (OS). The sequencing analyses (mRNAs and lncRNAs) of OS were conducted followed by differentially expressed mRNAs and lncRNAs (DEmRNAs and DElncRNAs) identification between U-2OS cells with has-miR-590-5p overexpression and negative control cells. Following this, the co-expression...
Fri Sep 11, 2020 08:14
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:Doxorubicin (DOX) has antitumor effects mediated by cell viability inhibition and by inducing cellular apoptosis. However, it has limited use in clinical applications due to various factors such as hydrophobicity, dose-dependent toxicity effects on normal tissues, short cycle retention time, and low targeting ability. This study aims at enhancing hydrophilicity of DOX to restrict its toxic effects to...
Fri Sep 11, 2020 08:13
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Thymoquinone (TQ), a natural anticancer agent exerts cytotoxic effects on several tumors by targeting multiple pathways, including apoptosis. Difluoromethylornithine (DFMO), an irreversible inhibitor of the ornithine decarboxylase (ODC) enzyme, has shown promising inhibitory activities in many cancers including leukemia by decreasing the biosynthesis of the intracellular polyamines. The present study aimed to...
Fri Sep 11, 2020 08:06
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:MiR-887 has been proved to promote the tumorigenesis in diverse cancers, but its function and downstream mechanism in hepatocellular carcinoma remain obscure.Methods:Quantitative real-time polymerase chain reaction was performed to detect the expression levels of miR-887 in hepatocellular carcinoma tissues and cell lines. MiR-887 mimics and miR-887 inhibitor were transfected into Huh7 and MHCC97H to...
Fri Sep 11, 2020 08:05
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Hepatocellular carcinoma (HCC) is a severe disease with high mortality in the world. Emerging evidence has suggested that lncRNAs play an important role in cancer progression, including HCC. This study aimed to comprehensively investigate the effect of lncRNA RHPN1 antisense RNA 1 (RHPN1-AS1) on HCC and its underlying molecular mechanism. In this study, we evaluated the expressions of lncRNA RHPN1-AS1 and miR-7-5p...
Thu Sep 10, 2020 07:00
Publication date: Available online 10 September 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Yan Zhang, Danh C. Do, Xinyue Hu, Ji Wang, Yilin Zhao, Sumita Mishra, Xin Zhang, Mei Wan, Peisong Gao
Fri Sep 11, 2020 12:21
Publication date: Available online 10 September 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Koichiro Asano, Akira Hebisawa, Takashi Ishiguro, Noboru Takayanagi, Yasuhiko Nakamura, Junko Suzuki, Naoki Okada, Jun Tanaka, Yuma Fukutomi, Shigeharu Ueki, Koichi Fukunaga, Satoshi Konno, Hiroto Matsuse, Katsuhiko Kamei, Masami Taniguchi, Terufumi Shimoda, Tsuyoshi Oguma, Japan ABPM research program
Fri Sep 11, 2020 12:21
Publication date: Available online 10 September 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Jonathan T. Sims, Venkatesh Krishnan, Ching-Yun Chang, Sarah M. Engle, Giacomo Casalini, George H. Rodgers, Nicoletta Bivi, Brian J. Nickoloff, Robert J. Konrad, Stephanie de Bono, Richard E. Higgs, Robert J. Benschop, Silvia Ottaviani, Anabela Cardoso, Ajay Nirula, Mario Corbellino, Justin Stebbing
Fri Sep 11, 2020 12:21
Water plays a key role in the functioning of wetlands and a shortage or contamination of it leads to changes in habitat conditions and degradation of ecosystems. This article scrutinizes the impact of climate change on the hydrological characteristics of floods (maximum flow, duration, volume) in the River Biebrza wetlands (North-East Poland). We analysed the trends in duration and volume of flood and maximum discharges in the historical period 1970–2000 and predicted these for the future periods...
Fri Sep 11, 2020 03:00
The BioBrick standard makes possible iterated pairwise assembly of cloned parts without any depletion of unique restriction sites. Every part that conforms to the standard is compatible with every other part, thereby fostering a worldwide user community. The assembly methods, however, are labor intensive or inefficient compared to some newer ones so the standard may be falling out of favor. An easier way to assemble BioBricks is described herein. Plasmids encoding BioBrick parts are purified from...
Fri Sep 11, 2020 03:00
Bark beetles are feared as pests in forestry but they also support a large number of other taxa that exploit the beetles and their galleries. Among arthropods, mites are the largest taxon associated with bark beetles. Many of these mites are phoretic and often involved in complex interactions with the beetles and other organisms. Within the oribatid mite family Scheloribatidae, only two of the three nominal species of Paraleius have been frequently found in galleries of bark beetles and on the beetles...
Fri Sep 11, 2020 03:00
Biominerals are crucial to the fitness of many organism and studies of the mechanisms of biomineralization are driving research into novel materials. Biomineralization is generally controlled by a matrix of organic molecules including proteins, so proteomic studies of biominerals are important for understanding biomineralization mechanisms. Many such studies identify large numbers of proteins of unknown function, which are often of low sequence complexity and biased in their amino acid composition....
Fri Sep 11, 2020 03:00
Intergenerational implications of alcohol intake: metabolic disorders in alcohol-naïve rat offspring
Alcohol drinking may be associated with an increased risk of various metabolic diseases. Rat lines selectively bred for alcohol preference and alcohol avoidance constitute an interesting model to study inherited factors related to alcohol drinking and metabolic disorders. The aim of the present study was to compare the levels of selected laboratory biomarkers of metabolic disorders in blood samples from naïve offspring of Warsaw alcohol high-preferring (WHP), Warsaw alcohol low-preferring (WLP),...
Fri Sep 11, 2020 03:00
Abstract Extrahepatic bile duct (EHBD) cancer is a devastating cancer, and more common in Asian countries than in Western countries. Histological grading continues to be a highly relevant factor in prognosis and management of many kinds of cancer, however no uniform histological grading system exists for EHBD cancer. Histological heterogeneity within tumors is a problem in the evaluation of EHBD cancer. We developed an EHBD histological grading scheme to evaluate tumor differentiation pattern, and...
Thu Sep 10, 2020 11:00
Median artery accompanied the median nerve and completed the superficial palmar arch laterally. Abstract The median artery has been considered as an embryonic structure, which normally regresses around the 8th week of gestation. However, various prevalences have been reported in adults since the 18th century. Furthermore, in a study by Henneberg and George (1995; Am J Phys Anthropol 96, 329–334), has suggested that increasing prevalence of the median artery during the 20th century was a ‘possible...
Thu Sep 10, 2020 20:40
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Background/purposeThis study examined clinical and histological parameters of primary dermal melanoma (PDM) to aid in its distinction from dermal metastasis.MethodsRetrospective analysis of a prospective cohort of PDM patients. Includes patients fulfilling the strict histologic criteria for PDM (N = 9) and patients who did not, but clinically, unequivocally had an intradermal melanoma—clinical PDM (cPDM; N = 17).Histopathology slides were...
Fri Sep 11, 2020 08:06
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Fri Sep 11, 2020 08:05
Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundTreatment practices vary for lentigo maligna (LM). Staged excision with circumferential margin control (SECMC) has the potential to achieve low recurrence rates.ObjectivesTo evaluate the clinical outcomes of SECMC using permanent, paraffin-embedded sections and delayed reconstruction.MethodsWe conducted a retrospective, uncontrolled, observational cohort study involving patients who underwent staged excision for LM of the head and...
Fri Sep 11, 2020 08:04
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Thu Sep 10, 2020 14:20
Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundStevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening drug-induced dermatologic conditions. SJS/TEN occurs in 1-10 per 10 000 patients taking carbamazepine (CBZ) (Pratt VM, McLeod HL, Rubinstein WS et al. Medical Genetics Summaries. National Center for Biotechnology Information US; 2018: 1-527). The development of SJS/TEN is associated with variable drug metabolism and presence of an at-risk HLA...
Thu Sep 10, 2020 14:19
AbstractThis article is protected by copyright. All rights reserved.
Thu Sep 10, 2020 22:39
Abstract ObjectiveShared decision‐making (SDM) occurs when physicians and patients jointly select treatment that aligns with patient care goals. Incorporating patient preferences into the decision‐making process is integral to successful decision‐making. This study explores factors influencing treatment selection in older patients with early‐stage breast cancer (EBC).MethodsThis qualitative study included women age ≥65 with EBC. To understand role preferences, patients completed the Control Preferences...
Thu Sep 10, 2020 20:39
Evaluation of Routine Blood Tests for Diagnosis of Suspected Coronavirus Disease 2019. Clin Lab. 2020 Sep 01;66(9): Authors: Santotoribio JD, Nuñez-Jurado D, Lepe-Balsalobre E RESULTS: Two hundred three patients (101 females, 102 males) with ages between 18 and 96 years (mean = 61.3) were studied. Ninety-four were COVID-19 and 109 were NON-COVID-19. Plasma ferritin level was the most accurate biomarker (AUC = 0.847 and 0.804 in women and men, respectively). The following diagnostic criteria...
Fri Sep 11, 2020 10:19
The enzyme 3‐methylglutaconyl coenzyme A (CoA) decarboxylase (called AibA/AibB), catalyzes the decarboxylation of 3‐methylglutaconyl CoA to generate 3,3‐dimethylacrylyl‐CoA, which is an important step in the biosynthesis of isovaleryl‐coenzyme A in Myxococcus xanthus when the regular pathway is blocked. A novel mechanism has previously been proposed for this enzyme, involving a pericyclic transition state, which would make AibA/AibB unique among decarboxylases. Herein, we use density functional...
Fri Sep 11, 2020 11:31
An endohedrally functionalized self‐assembled Fe 4 L 6 cage complex can catalyze Pictet‐Spengler cyclizations of tryptophols and various aldehyde derivatives, showing strong rate accelerations and size‐selectivity. Selective molecular recognition of substrates controls the reactivity, and the cage is capable of binding and activating multiple different species along the multistep reaction pathway. The combination of a functionalized active site, size‐selective reactivity and multistep activation,...
Fri Sep 11, 2020 11:31
N‐heterocyclic nitrogen Lewis acids are a recent addition to the field of organic chemistry. Based on nitrenium cations, these acids where previously shown to generate Lewis adducts when combined with the appropriate Lewis bases. In this article, a triazinium‐based Lewis acid was combined with t Bu 3 P to generate a frustrated Lewis pair (FLP) capable of cleaving, for the first time, Si‐H bonds in silanes. Whereas low yields were initially encountered due to insufficient Lewis acidity, a new...
Thu Sep 10, 2020 22:54
The construction of artificial cells from inanimate molecular building blocks is one of the grand challenges of our time. In addition to being used as simplified cell models to decipher the rules of life, artificial cells have the potential to be designed as micromachines deployed in a host of clinical and industrial applications. The attractions of engineering artificial cells from scratch, as opposed to re‐engineering living biological cells, are varied. However, it is clear that artificial cells...
Thu Sep 10, 2020 22:00
The syntheses of the novel silicon‐bridged tris(tetraorganotin) compounds MeSi(CH2SnPh2R)3 (2, R ═ Ph; 5, R ═ Me3SiCH2) and their halogen‐substituted derivatives MeSi(CH2SnPh(3‐n) In)3 (3, n ═ 1; 4, n ═ 2) and MeSi(CH2SnI2R)3 (6, R ═ Me3SiCH2) are reported. The reaction of compound 4 with di‐t‐butyltin oxide, (t‐Bu2SnO)3 gives the oktokaideka‐nuclear (18‐nuclear) molecular diorganotin oxide [MeSi(CH2SnPhO)3]6 (7) while the reaction of 6 with sodium hydroxide, NaOH, provides the trikonta‐nuclear (30‐nuclear)...
Thu Sep 10, 2020 20:53
Protein dynamics is the heart of all cellular processes. Here, we utilize the dHis‐Cu(II)NTA motif to obtain site‐specific information on dynamics for both an α‐helix and ß‐sheet site of GB1, the immunoglobulin binding domain of protein G. Spectral features found in our CW‐EPR measurements were consistent with the overall rigid nature of GB1 and with predictions from molecular dynamics simulations, Using this information, we show the potential of this approach to elucidate the role of dynamics in...
Thu Sep 10, 2020 19:23
Supercapacitors (SCs), showing excellent power density, long service life and high reversibility, have got extensive attention because of the increasing request for energy storage devices. To improve further their performance, it is essential to develop advanced electrode materials. A group of materials, which are porous crystalline solids, named metal‐organic frameworks (MOFs) have proved to be excellent templates to synthesize functional materials to be employed in the preparation of electrodes...
Thu Sep 10, 2020 18:31
i‐Corona[3]arene[3]tetrazines were synthesized straightforwardly from the nucleophilic aromatic substitution reaction of resorcinol and its derivatives with 3,6‐dichlorotetrazine in a one‐pot fashion under mild conditions. All resulting macrocycles adopted 1,3,5‐alternate conformation irrespective of the nature of the substituents on both upper‐ and lower‐rims. i‐Corona[3]arene[3]tetrazine was found to self‐regulate its macrocyclic conformation and cavity to recognize anions with binding constants...
Thu Sep 10, 2020 18:29
Distonic radical cations (DRCs) with spatially separated charge and radical sites have, so far, largely been observed by gas‐phase mass spectrometry and/or matrix isolation spectroscopy work. Herein, we disclose the isolation of a crystalline dicarbondiphosphide‐based β‐distonic radical cation salt 3 •+ (BARF) (BARF = [B(3,5‐(CF 3 ) 2 C 6 H 3 ) 4 )] – ) stable at room temperature via a one‐electron‐oxidation‐induced intramolecular skeletal rearrangement reaction. Such a species has...
Thu Sep 10, 2020 18:23
Optical multiplexing based on luminescent materials with tunable color/lifetime holds potential applications in information storage and security. However, the available tunable luminescent materials reported so far still suffer from several drawbacks of low efficiency or poor stability, thus restraining their further applications. Here, we demonstrate a strategy to develop the efficient and stable lanthanide coordination polymers (LCPs) with tunable luminescence as a new option for optical multiplexing....
Thu Sep 10, 2020 17:58
H 2 production via water electrolysis is of great significance in clean energy pruduction, which, however, suffers from the sluggish kinetics of anodic oxygen evolution reaction (OER). Moreover, the anode product, O 2 , which is of rather low value, may lead to the dangerous explosion hazard and the generation of membrane‐degradable reactive oxygen species. Herein, to address aforementioned issues of electrocatalytic H 2 production, the most recent advances are summarized in three stages based...
Thu Sep 10, 2020 17:56
Thermodynamic knowledge of the metal‒ligand (M‒L) σ‐bond strength is crucial to understanding metal‐mediated transformations, but it is rarely presented in literature. Here, we developed a general methodology for determining the Pd‒X (X = OR and NHAr) bond heterolysis energies (ΔGhet(Pd‒X)) in DMSO taking [(tmeda)PdArX] (tmeda = N,N,N’,N’‐tetramethylethylenediamine) as the model complexes. The first ΔGhet(Pd‒X) scales here derived span a range of 2.6‒9.0 kcal/mol for ΔGhet(Pd‒O)s and of 14.5‒19.5...
Thu Sep 10, 2020 16:55
A Pd‐catalyzed regio‐ and stereoselective alkynylallylation of a specific C–C σ bond in cyclopropenes, using allyl propiolates as both allylation and alkynylation reagents, has been achieved for the first time. By merging selective C( sp 2 )–C( sp 3 ) bond scission with conjunctive cross‐couplings, this decarboxylative reorganization reaction features fascinating atom and step economy and provides an efficient approach to highly functionalized dienynes from readily available substrates. Without...
Thu Sep 10, 2020 12:27
Summary Disorders of arousals are common sleep disorders characterized by complex motor behaviours that arise episodically out of slow‐wave sleep. Psychological distress has long been associated with disorders of arousal, but this link remains controversial, especially in children and adolescents. The aim of this multi‐centre study was to characterize behavioural and emotional problems in a sample of children/adolescents with disorders of arousal, and to explore their relationship with the severity...
Thu Sep 10, 2020 15:23
Parental care is a key component of an organisms reproductive strategy that is thought to trade-off with allocation towards immunity. Yet it is unclear how caring parents respond to pathogens: do infected parents reduce their amount of care as a sickness behaviour or simply from being ill, or do they prioritise their offspring by maintaining high levels of care? Here we explored the consequences of infection by the pathogen Serratia marcescens on mortality, time spent providing care, reproductive...
Sun Sep 13, 2020 03:00
Summary Background Crenigacestat is a potent Notch inhibitor that decreases Notch signaling and its downstream biological effects. Here, we report the results from Part F of study 16F-MC-JJCA designed to evaluate the safety, pharmacokinetics (PK), and antitumor activity of crenigacestat with prednisone in advanced or metastatic cancer. The combination was planned to mitigate gastrointestinal toxicities. Methods Eligible patients (Study Part F) received crenigacestat loading dose...
Fri Sep 11, 2020 03:00
Summary Today, pancreatic cancer (PC) is a major health problem in the United States. It remains a challenge to develop efficacious clinically useful PC therapies. New avenues, based on translational approaches and innovative validated biomarkers could be a preclinical option to evaluate PC drug candidates or drug combinations before clinical trials. Herein, we describe evaluation of combination therapies by incorporating a novel pathway modulator, p53-Activator Wnt Inhibitor-2...
Fri Sep 11, 2020 03:00
DNA barcoding was used to identify prey fragments recovered from the stomachs of lionfish harvested during the 2016 Sarasota Lionfish Derby. A total of 305 prey fragments were recovered from 50 stomachs (mean = 4.6 per stomach), of which 184 (60.3%) fragments could be identified to either species or genus when Cytochrome Oxidase I (COI) sequences were queried against the Barcode of Life Database. We identified 21 fish prey species which represented fourteen families and accounted for 95.7% of genetically...
Fri Sep 11, 2020 03:00
Two new species of the order Plectida are described from Chatham Rise, New Zealand. Leptolaimus dififtinus sp. nov. is characterised by the short body 319–420 microns long, truncate labial region slightly offset from body contour and bearing conspicuous outer labial papillae, cephalic setae 1.3–1.4 microns long, amphid located 4–9 microns from anterior end, lateral alae originating from middle of buccal cavity length, female without supplements, male with precloacal and postcloacal pairs of subventral...
Fri Sep 11, 2020 03:00
Nepenthes maximoides sp. nov. (Sect. Alatae) is described and assessed as Critically Endangered (Possibly Extinct) from Luzon, Philippines and appears unrecorded in 110 years. The spectacular, large, narrowly funnel-shaped upper pitchers, lids with recurved basal and filiform apical appendages, unlike any other species in the Philippines, closely resemble those of N. maxima (Sect. Regiae) of Sulawesi–New Guinea, likely due to convergent evolution. Following recent phylogenomic analysis, sect. Alatae...
Fri Sep 11, 2020 03:00
Background Immune checkpoint inhibitors are being considered for locally advanced cervical cancer (LACC) together with standard‐of‐care pelvic chemoradiation (CRT). However, the safety of the combination and its optimal schedule are unknown. Defining the safety of the combination is a primary objective of a study examining concurrent and sequential schedules. This article presents a safety analysis that was fully accrued and met reporting requirements. Methods Pembrolizumab was given after...
Thu Sep 10, 2020 18:32
Clinical characteristics and risk factors for mortality in hematologic patients affected By COVID‐19
Background Patients with cancer are considered highly vulnerable to the recent coronavirus disease 2019 (COVID‐19) pandemic. However, there are still few data on COVID‐19 occurring in hematologic patients. Methods One hundred two patients with COVID‐19 symptoms and a nasopharyngeal swab positive for severe acute respiratory syndrome coronavirus 2 seen at 2 hematologic departments located in Lombardy, Italy, during March 2020 were studied. Risk factors for acquiring COVID‐19 were analyzed by...
Thu Sep 10, 2020 17:38
Background The purpose of this retrospective biomarker study of the Canadian Cancer Trials Group (CCTG) MA.31 randomized phase 3 trial (lapatinib vs trastuzumab) of HER2‐positive metastatic breast cancer (MBC) was to evaluate the prognostic and predictive biomarker utility of pretreatment serum programmed death ligand 1 (PD‐L1) levels. Methods CCTG MA.31 accrued 652 HER2‐positive patients; 387 had serum available (185 in the trastuzumab arm and 202 in the lapatinib arm). The Ella immunoassay...
Thu Sep 10, 2020 16:20
Background Lymph node metastases (LNM) rarely occur in adult extremity soft‐tissue sarcoma (STS), affecting approximately 5% of patients. To the authors' knowledge, few studies to date have evaluated the prognosis and survival of patients with LNM. Methods A retrospective review was performed of a single‐center, prospectively collected STS database. Demographic, treatment, and oncologic data for patients with STS of the extremity with LNM were obtained from clinical and radiographic records....
Thu Sep 10, 2020 16:11
Background Socioeconomic and demographic categories such as income, race, insurance status, and treatment center type are associated with outcomes in acute leukemia. This study was aimed at determining whether the distance to treatment center affects overall survival for children and young adults with acute leukemia. Methods The National Cancer Database was queried for patients 39 years old or younger who were diagnosed with acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL)....
Thu Sep 10, 2020 16:11
The decline in diarrhoeal disease-related mortality globally has been attributed to the use of oral rehydration solution (ORS) and zinc supplementation. However, data on ORS and zinc supplementation in Sudan a...
Thu Sep 10, 2020 03:00
Plant carnivory is distributed across the tree of life and has evolved at least six times independently, but sequenced and annotated nuclear genomes of carnivorous plants are currently lacking. We have sequenc...
Thu Sep 10, 2020 03:00
Critical illness polyneuropathy (CIP) is a common complication of severe systemic illness treated in intensive care medicine. Ischemic stroke leads to an acute critical injury of the brain with hemiparesis, im...
Thu Sep 10, 2020 03:00
Abstract Purpose Platelet-rich fibrin (PRF) such as leucocyte-rich PRF (L-PRF) and injectable form of PRF (i-PRF) are widely used in various surgical applications. L-PRF- and i-PRF-derived cytokine variations and functional pathways are still unexplored. The aim of the study was to evaluate the expression pattern of Th1-, Th2-, and Th17-related cytokines by L-PRF and i-PRF under in vitro. ...
Fri Sep 11, 2020 03:00
Abstract Clostridioides (Clostridium) difficile (C. difficile) infection is one of the most common cause of increased morbidity and mortality. Approximately 500,000 C. difficile infections (CDIs) occur each year in the United States and they result in more than 29,000 deaths. Patients with hematologic diseases are at a higher risk for this infection due to frequent hospitalization and exposure to treatment‐associated risk factors. While several currently available antimicrobial agents...
Thu Sep 10, 2020 15:54
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveThis study aimed to determine the effect of parathyroid hormone-related protein (PTHrP) on proliferation of cardiac fibroblasts (CFs) in primary cultures of neonatal Wistar rats.MethodsDifferent PTHrP concentrations were added to CFs of neonatal Wistar rats and the cells were grouped according to the concentrations added. A verapamil (VPL) group and a calcitriol (CAL) group were also established. Changes in cell...
Thu Sep 10, 2020 13:52
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveArterial elasticity is important for assessing the state of an artery. This cross-sectional study aimed to non-invasively examine stiffness parameters of the ascending aorta in patients with type 2 diabetes mellitus (T2DM).MethodsWe studied 58 patients, including 38 with T2DM and 20 controls. The stiffness of the aorta was evaluated during transthoracic echocardiography. Aortic parameters of stiffness, such as...
Thu Sep 10, 2020 13:09
Journal of International Medical Research, Volume 48, Issue 9, September 2020. Since the outbreak of coronavirus disease 2019 (COVID-19) in December 2019, an epidemic has spread rapidly worldwide. COVID-19 is caused by the highly infectious severe acute respiratory syndrome coronavirus-2. A 42-year-old woman presented to hospital who was suffering from epigastric discomfort and dyspepsia for the past 5 days. Before the onset of symptoms, she was healthy, and had no travel history to Wuhan or contact...
Thu Sep 10, 2020 10:29
Journal of International Medical Research, Volume 48, Issue 9, September 2020. Cerebral fat embolism (CFE) syndrome is relatively rare in clinical practice. Currently, there is no uniform standard of magnetic resonance imaging for the diagnosis of the disease. In this report, we present head computed tomography and magnetic resonance images (T2-weighted images, fluid-attenuated inversion recovery images, diffusion-weighted images, and susceptibility-weighted images) in a case of CFE. This report...
Thu Sep 10, 2020 10:23
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveTo study the role of vitamin E in stroke-associated pneumonia.MethodsWe selected 183 patients with stroke-related pneumonia who were divided into different nutrition groups according to the Mini Nutritional Assessment score. Patients were then administered different doses of vitamin E.ResultsCD55 and CD47 levels in patients taking vitamin E across different nutrition score groups were better than those in patients...
Thu Sep 10, 2020 10:20
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveThe pathogenesis of chronic obstructive pulmonary disease (COPD) remains elusive. Here, we assessed the correlation between CD8+ T cell frequencies and autophagy in COPD patients.MethodsSubjects were divided into three groups (n = 30 patients/group): (1) COPD patients in the stable phase; (2) smokers with normal lung function; and (3) non-smokers with normal lung function. Flow cytometry was used to enumerate...
Thu Sep 10, 2020 10:19
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveOur objective was to explore the molecular pathogenesis of the onset of gout and the mechanism underlying the effect of interleukin (IL)-37 on PDZ domain-containing 1 (PDZK1) protein through the nuclear factor-κB signaling pathway.MethodsReal-time PCR and western blotting were used to detect expression of PDZK1 mRNA and protein, respectively, in the HK-2 cell line. The inhibitors pyrrolidine dithiocarbamate (PDTC)...
Thu Sep 10, 2020 10:17
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveTo evaluate the effects of a video-assisted education intervention on informed consent and patient education for peripherally inserted central catheters (PICCs).MethodsWe conducted a randomized controlled trial comparing the effects on informed consent of video-assisted patient education and traditional face-to-face discussion in a catheter outpatient ward of a cancer centre in Guangzhou, China, in 2018. Participants...
Thu Sep 10, 2020 10:10
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveSepsis-associated encephalopathy (SAE) is a common complication of sepsis, and excessive endoplasmic reticulum (ER) stress is closely correlated with the cell injury caused by sepsis. This study aimed to analyze the possible role of ER stress in SAE cell models.MethodsPC12 and MES23.5 cells were treated with increasing concentrations of lipopolysaccharides (LPS). The Cell Counting Kit-8 assay was used to detect...
Thu Sep 10, 2020 09:16
Journal of International Medical Research, Volume 48, Issue 9, September 2020. In December 2019, a new respiratory disease manifesting as viral pneumonia emerged in Wuhan, China. Isolation and identification of the virus showed that the pathogen causing this disease was a novel coronavirus. On January 12, 2020, the World Health Organization named the novel coronavirus causing the outbreak 2019 novel coronavirus (2019-nCoV). The disease caused by the virus was named coronavirus disease 2019 (COVID-19)....
Thu Sep 10, 2020 07:56
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveTo investigate the safety of radiofrequency ablation for reducing inflammatory cytokines and the left atrial diameter in patients with atrial fibrillation (AF).MethodsA total of 200 patients with AF who were admitted to our hospital from December 2015 to April 2017 were included in this prospective analysis. Fifty patients were treated with conventional AF medication alone (AF medication group) and 50 patients...
Thu Sep 10, 2020 07:54
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveOur objective was to explore the prognostic role of long noncoding RNA (lncRNA) SH3PXD2A-AS1 in esophageal squamous cell carcinoma (ESCC).MethodsAn SH3PXD2A-AS1 expression dataset was retrieved and analyzed from The Cancer Genome Atlas database, and SH3PXD2A-AS1 expression was determined in our cohort of 134 ESCC patients by using quantitative PCR. The clinical significance of SH3PXD2A-AS1 expression was investigated...
Thu Sep 10, 2020 07:51
Abstract Background The anti–interleukin 13 (IL‐13) monoclonal antibody lebrikizumab improves lung function in patients with moderate to severe uncontrolled asthma, but its effects on airway inflammation and remodelling are unknown. CLAVIER was designed to assess lebrikizumab’s effect on eosinophilic inflammation and remodelling. Objective To report safety and efficacy results from enrolled participants with available data from CLAVIER. Methods We performed bronchoscopy on patients...
Thu Sep 10, 2020 13:05
Abstract Background Although hen’s egg allergy is more prevalent in children, up to 0.6% of adults from different European countries suffers from a persistent or newly‐onset hen’s egg allergy, making accurate diagnosis in adults necessary. However, sensitisation to hen’s egg extracts, components and linear epitopes are solely studied in children. Methods Hen’s egg allergic (n=16) and tolerant (n=20) adults were selected by sensitisation towards recombinant components rGal d 1 and/or 3....
Thu Sep 10, 2020 12:59
Abstract Objective To determine the role of routine cervical Pap smears in detecting endometrial carcinomas. Method A retrospective study was carried out from the histopathology archives for cases diagnosed as endometrial carcinomas with Pap smears within 6 months before histological diagnosis. The demographic details, reports of Pap smears and other tumor parameters on histopathology were noted. Results We identified 380 of 482 cases of endometrial carcinoma with a documented Pap...
Thu Sep 10, 2020 17:49
Abstract Low‐grade endometrial stromal sarcoma (LGESS) is a rare malignant uterine tumor with the potential to metastasize years after the primary resection. There is a broad differential diagnosis for endometrial stromal sarcomas (ESS), including both benign and malignant entities. Herein, we present the case of a 64‐year‐old female with metastatic LGESS to the lung, diagnosed by cytology, 24 years after her initial presentation. This report discusses the cytomorphologic and histopathologic characteristics,...
Thu Sep 10, 2020 17:49
Abstract Purpose Functional hypothalamic amenorrhea (FHA) occurs in response to exaggerated stressors with or without body weight loss. Various hormones, neurotransmitters, and neuromodulators are involved in the control of GnRH and kisspeptin is one of them. Our study aimed to evaluate the putative temporal coupling between kisspeptin and GnRH-induced LH pulsatile secretion. ...
Fri Sep 11, 2020 03:00
Methionine adenosyltransferase (MAT), which catalyzes the biosynthesis of S-adenosylmethionine from L-methionine and ATP, is an ancient, highly conserved enzyme present in all three domains of life. Although the MAT enzymes of each domain are believed to share a common ancestor, the sequences of archaeal MATs show a high degree of divergence from the sequences of bacterial and eukaryotic MATs. However, the structural and functional consequences of this sequence divergence are not well understood....
Thu Sep 10, 2020 03:00
Background: Secretory carcinoma (SC), originally described as mammary analogue SC, is a predominantly low-grade salivary gland neoplasm characterized by a recurrent t(12;15)(p13;q25) translocation, resulting in ETV6-NTRK3 gene fusion. Recently, alternative ETV6-RET, ETV6-MAML3, and ETV6-MET fusions have been found in a subset of SCs lacking the classic ETV6-NTRK3 fusion transcript, but still harboring ETV6 gene rearrangements. Design: Forty-nine cases of SC revealing typical histomorphology...
Fri Sep 11, 2020 09:30
Neuroendocrine carcinoma (NEC) is an aggressive malignant tumor that rarely arises from the gallbladder. Here, we investigated the clinicopathologic and immunohistochemical characteristics of 34 NECs of the gallbladder. The patients were predominantly women (68%) with a median age of 63 years (range, 37 to 82 y). NECs frequently occurred in the fundus (44%) as mass-forming lesions (66%). Histologically, 17 tumors were of small cell type, and another 17 were of large cell type. Twenty-three cases...
Fri Sep 11, 2020 09:30
Steatohepatitic hepatocellular carcinoma (SH-HCC) is a variant of hepatocellular carcinoma (HCC) with established association with nonalcoholic steatohepatitis (NASH), while its association with alcoholic steatohepatitis (ASH) is unclear. We studied 2 cohorts of patients who underwent resection for HCC in the setting of steatohepatitis. In our Mount Sinai (New York) cohort, we found SH-HCC in 17/24 (71%) patients with NASH and in 14/19 (74%) patients with ASH, while SH-HCC was the predominant tumor...
Fri Sep 11, 2020 09:30
Trophoblastic differentiation (including choriocarcinoma) arising in urothelial carcinoma has been described in numerous case reports, but never in a single series. We present a series of these tumors, describing the morphologic spectrum, applying traditional and novel immunohistochemical stains, and characterizing clinical follow-up. We identified 16 cases, arising predominantly in the bladder (N=14), but also the ureter (N=1) and prostatic urethra (N=1). Six of our cases (38%) contained invasive...
Fri Sep 11, 2020 09:30
Hirschsprung disease (HD) is a congenital disorder of the enteric nervous system that occurs in ∼1 in 5000 live births. It is characterized by the absence of ganglionic cells (GCs) in the distal intestine. The diagnosis relies on the thorough analysis of a rectal suction biopsy (RSB), which must show a complete absence of GCs after careful examination of at least 100 serial sections. Such a negative characteristic explains the difficulty of this diagnosis. Moreover, GCs may be immature in very young...
Fri Sep 11, 2020 09:30
Molecular analysis has reshaped the landscape of high grade sinonasal tumors by defining novel entities and identifying recurrent mutations in established tumor types. However, sinonasal teratocarcinosarcoma (TCS), a rare and aggressive tumor with intermixed teratomatous, carcinomatous, and sarcomatous elements, remains poorly understood. The multiphenotypic differentiation of TCS has engendered persistent controversy about its histogenesis and leads to diagnostic overlap with several other malignancies....
Fri Sep 11, 2020 09:30
We investigated the prognostic value of a range of histologic parameters in medullary thyroid carcinoma (MTC) to design a grading system to predict overall survival. We assessed 76 patients with MTCs undergoing primary tumor resection for age, sex, tumor size, vascular space invasion, lymph node metastasis, multiple endocrine neoplasia type 2 (MEN2) status, mitotic count, Ki-67 proliferative index, spindled morphology, sheet-like growth pattern, coagulative necrosis, incipient necrosis, nuclear grade,...
Fri Sep 11, 2020 09:30
Monomorphic posttransplant lymphoproliferative disorders have been defined as lymphoid or plasmacytic proliferations that fulfill criteria for one of the B-cell or T/NK-cell neoplasms recognized in immunocompetent hosts in the current WHO Classification. Low-grade B-cell neoplasms have historically been excluded from this category, although rare reports of marginal zone lymphoma (MZL) have been described. We report 9 cases of posttransplant Epstein-Barr virus-negative MZL, all arising in solid organ...
Fri Sep 11, 2020 09:30
The eighth edition of the American Joint Committee on Cancer (AJCC) Staging Manual attempts to address ambiguity in the pT category assignment for colon cancer from prior editions. Despite modifications, the distinction between the pT3 and pT4a categories continues to be a source of diagnostic confusion. In this study, we assessed interobserver agreement among pathologists from different institutions in the application of AJCC eighth edition criteria for categorizing deeply invasive colonic adenocarcinomas....
Fri Sep 11, 2020 09:30
It is becoming increasingly important to obtain detailed diagnostic information on small-volume tissue biopsies, such as core needle biopsies. This is particularly crucial in the workup and diagnosis of classic Hodgkin lymphoma (CHL) and other morphologically similar lymphomas such as T-cell/histiocyte-rich large B-cell lymphoma (THRLBL), where small-volume lymph node biopsies often represent the frontline tissue source, and the differential diagnosis includes a reactive process. Immunohistochemical...
Fri Sep 11, 2020 09:30
We report a series of 6 melanocytic proliferations harboring both NRAS and IDH1 hotspot mutations. Clinically, there was no specific sex-ratio, ages ranged from 18 to 85 years, and the trunk and limbs were the most affected localizations. In half of the cases, progressive modification of a pre-existing nevus was reported. Morphologically, all tumors were predominantly based in the dermis and the most striking pathologic finding was the presence of a background architecture of congenital-type nevi...
Fri Sep 11, 2020 09:30
Chronic intervillositis of unknown etiology (CIUE) is a rare placental disease characterized by intervillous infiltration of maternal macrophages and associated with poor pregnancy outcomes and a high risk of recurrence in subsequent pregnancies. Its pathophysiology remains unclear and prognostic factors have not yet been established. In addition, clear relationships between the histologic extent of lesions and the severity of perinatal outcomes have not been demonstrated. Our objectives were to...
Fri Sep 11, 2020 09:30
Deep penetrating nevi (DPNs) are intermediate grade lesions which have the capacity to recur, metastasize, or progress to melanoma. Differentiating DPN from other melanocytic lesions including blue and cellular blue nevi can be diagnostically challenging, and markers to distinguish these entities can be useful. Mutations of the β-catenin and mitogen-activated protein kinase pathways have recently been elucidated as distinctive of DPN. This pathway can subsequently activate lymphoid enhancer–binding...
Fri Sep 11, 2020 09:30
Invasive stratified mucinous carcinoma (iSMC) has been suggested to represent an aggressive subtype of endocervical adenocarcinoma. We sought to investigate the outcomes of iSMC and determine which clinical and pathologic parameters may influence the prognosis. Slides from 52 cases of iSMC were collected and classified as follows: pure iSMC (>90% of the entire tumor) and iSMC mixed with other human papillomavirus–associated adenocarcinoma components (miSMC) (>10%, but
Fri Sep 11, 2020 09:30
Background: Conservative management with progestin is a treatment option for atypical hyperplasia (AH). However, pathologic diagnosis of residual/recurrent lesions is often problematic because of the profound morphologic changes induced by progestin and the lack of established diagnostic criteria for progestin-treated residual AH. Methods: We conducted a longitudinal study of 265 endometrial biopsies from 54 patients with a history of AH on progestin therapy. Patient outcomes were divided...
Fri Sep 11, 2020 09:30
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