Comparison of cervical vertebral anomalies and sella turcica bridging in different growth stages with various vertical skeletal growth patterns. Surg Radiol Anat. 2020 Sep 10;: Authors: Atilla AO, Ozturk T, Yagci A Abstract PURPOSE: To compare cervical vertebral anomalies and sella turcica bridging (STB) in different growth stages in orthodontic patients with different vertical skeletal growth patterns. METHODS: Lateral cephalometric...
Sat Sep 12, 2020 14:16
Spinal anastomosed remnant imprints of vertebral veins linking the transverse foramina: a case report of a novel anatomic variant of the cervical venous plexus. Surg Radiol Anat. 2020 Sep 10;: Authors: Al-Sharydah AM, Al-Suhibani SS, Al-Muhanna AF, Al-Abdulwahhab AH Abstract PURPOSE: Despite various postulated classifications attempting to simplify the complex angioarchitecture of the cervical spine, the nomenclature of spinal variants and...
Sat Sep 12, 2020 14:16
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Datian Chen, Huiyu Wang
Sat Sep 12, 2020 14:15
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Fengyu Lin, Chao Song, Yanjun Zeng, Yi Li, Haitao Li, Ben Liu, Minhui Dai, Pinhua Pan
Sat Sep 12, 2020 14:15
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Shaobing Xie, Hua Zhang, Fengjun Wang, Yongzhen Liu, Kelei Gao, Junyi Zhang, Ruohao Fan, Shumin Xie, Zhihai Xie, Weihong Jiang
Sat Sep 12, 2020 14:15
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Shradha Bodkhe, Mayuri Nikam, Atul P. Sherje, Tabassum Khan, Vasanti Suvarna, Kavit Patel
Sat Sep 12, 2020 14:15
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Ya-fei Zhang, Fang-tian Bu, Na-na Yin, Ao wang, Hong-mei You, Ling Wang, Wen-Qian Jia, Cheng Huang, Jun Li
Sat Sep 12, 2020 14:15
FOXO3a-dependent Parkin regulates the development of gastric cancer by targeting ATP-binding cassette transporter E1. J Cell Physiol. 2020 Sep 10;: Authors: Ding D, Ao X, Li M, Miao S, Liu Y, Lin Z, Wang M, He Y, Wang J Abstract Gastric cancer (GC) is one of the most common malignant tumors in China and the third leading cause of cancer-related death. Parkin has been shown to be a tumor suppressor in a variety of malignancies, including GC....
Sat Sep 12, 2020 14:14
The effects of malvidin on oxidative stress parameters and inflammatory cytokines in LPS-induced human THP-1 cells. J Cell Physiol. 2020 Sep 10;: Authors: Bastin A, Sadeghi A, Nematollahi MH, Abolhassani M, Mohammadi A, Akbari H Abstract Malvidin is an anthocyanin which is involved in inhibiting inflammatory-related mediators in inflammatory diseases; however, its mechanism of action in THP-1 cells is not yet known. THP-1 is a human monocytic...
Sat Sep 12, 2020 14:14
Therapeutic management of the upper extremity (UE) function of people with spinal muscular atrophy (SMA) requires sensitive and objective assessment. Therefore, we aimed to measure physiologic UE function of S...
Fri Sep 11, 2020 03:00
Parkinson’s disease (PD) and essential tremor (ET) are movement disorders that can have similar clinical characteristics including tremor and gait difficulty. These disorders can be misdiagnosed leading to del...
Fri Sep 11, 2020 03:00
The use of hedgehog antagonists in cancer therapy: a comparison of clinical outcomes and gene expression analyses. Cancer Biol Ther. 2020 Sep 11;:1-11 Authors: Booker BE, Steg AD, Kovac S, Landen CN, Amm HM Abstract Hedgehog (HH) signaling, a critical developmental pathway, has been implicated in cancer initiation and progression. With vismodegib and sonidegib having been approved for clinical use, increasing numbers of HH inhibitors alone...
Sat Sep 12, 2020 14:04
Epigenetic age acceleration of early stage hepatocellular carcinoma tightly associated with hepatitis B virus load, immunoactivation, and improved survival. Cancer Biol Ther. 2020 Sep 11;:1-8 Authors: Fan X, Yuan H, Zhao S, Yang X, Shi R, Wang J, Zhao H Abstract Properly stratifying high-risk individuals with early stage hepatocellular carcinoma (HCC) is essential to identify patients in which the potentially therapies can be offered. To this...
Sat Sep 12, 2020 14:04
Intraoperative marking of the tumour resection surface for improved radiation therapy planning in head and neck cancer: preclinical evaluation of a novel liquid fiducial marker. Dentomaxillofac Radiol. 2020 Sep 11;:20200290 Authors: Steybe D, Russe MF, Ludwig U, Sprave T, Vach K, Semper-Hogg W, Schmelzeisen R, Voss PJ, Poxleitner P Abstract OBJECTIVE: To evaluate a novel liquid fiducial marker for intraoperative marking of the tumour resection...
Sat Sep 12, 2020 14:03
Qualitative evaluation of the general practitioner chronic non-communicable diseases training programme. BMC Med Educ. 2020 Sep 10;20(1):297 Authors: Zhang C, Fang F, Peng M, Zhao Y, Liu R, Jia C Abstract BACKGROUND: In China, general practitioners have limited ability to provide care for common chronic non-communicable diseases because they lack postgraduate training. In an attempt to improve general practitioners' skills in this regard, the...
Sat Sep 12, 2020 13:56
Stress, anxiety, self-efficacy, and the meanings that physical therapy students attribute to their experience with an objective structured clinical examination. BMC Med Educ. 2020 Sep 10;20(1):296 Authors: Ferreira ÉMR, Pinto RZ, Arantes PMM, Vieira ÉLM, Teixeira AL, Ferreira FR, Vaz DV Abstract BACKGROUND: Excessive stress and anxiety can impair learning. The objective structured clinical examination (OSCE) is a valuable tool to assess and...
Sat Sep 12, 2020 13:56
Burnout level and associated factors in a sub-Saharan African medical setting: prospective cross-sectional survey. BMC Med Educ. 2020 Sep 10;20(1):295 Authors: Mackanga JR, Mouendou Mouloungui EG, Iba-Ba J, Pottier P, Moussavou Kombila JB, Boguikouma JB Abstract BACKGROUND: Burnout in the hospital environment is a problem that affects care and training. Often explored in the high-income medical context, burnout is poorly studied in low and...
Sat Sep 12, 2020 13:56
642 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: upper respiratory tract infection These pubmed results were generated on 2020/09/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Sep 12, 2020 13:55
Solitary pulmonary capillary hemangioma presenting with a ground glass opacity: A case report & literature review. Int J Surg Case Rep. 2020 Aug 29;75:8-10 Authors: Komatsu T, Hara A, Date N, Fujinaga T, Kato T Abstract INTRODUCTION: Solitary pulmonary capillary hemangioma (SPCH) is a rare benign lung tumor that clinically resembles early lung cancer and precancerous pulmonary lesions that present with similar imaging manifestations. ...
Sat Sep 12, 2020 13:50
Meckel's diverticulum adenocarcinoma accompanied with vitelline duct remnant and huge cystic lesion: A rare case report. Int J Surg Case Rep. 2020 Sep 02;75:16-22 Authors: Tawada M, Misao Y, Ichikawa K, Tanaka H Abstract INTRODUCTION: Vitelline duct remnant (VDR) is a rare abnormality of the primitive yolk sac, and Meckel's diverticulum (MD) is the most common type. MD is a congenital small intestinal diverticulum that leaves the ileal side...
Sat Sep 12, 2020 13:50
Delayed symptomatic spinal adhesive arachnoiditis after surgery for thoracolumbar flexion-distraction injury: A case report. Int J Surg Case Rep. 2020 Aug 29;74:273-276 Authors: Lim DJ, Sohn JM Abstract BACKGROUND: Adhesive arachnoiditis is an uncommon lesion caused by an inflammatory reaction in spinal nerves. Reports of substantial symptomatic thoracolumbar (TL) adhesive arachnoiditis after spinal surgery are rare. To the best of our knowledge,...
Sat Sep 12, 2020 13:50
Primary tumors of the Posterior Pituitary gland: A systematic review of the literature in light of the new 2017 WHO classification of pituitary tumors. World Neurosurg. 2020 Sep 08;: Authors: Whipple SG, Savardekar AR, Rao S, Mahadevan A, Guthikonda B, Kosty J Abstract OBJECTIVE: CThe rare clinical entity of primary posterior pituitary tumors (PPTs) includes pituicytomas, granular cell tumors, spine cell oncocytomas, and sellar ependymomas....
Sat Sep 12, 2020 13:48
Current Advances in CAR T Cell Therapy for Malignant Mesothelioma. J Cell Immunol. 2020;2(4):192-200 Authors: Klampatsa A, Albelda SM Abstract Malignant mesothelioma is a relatively rare malignancy arising in the body's serosal surfaces, with malignant pleural mesothelioma (MPM) being the most common type. It is characterized by local spread within the thorax, poor prognosis and resistance to treatment. The development of various immunotherapeutic...
Sat Sep 12, 2020 13:48
Epithelioid malignant peripheral nerve sheath tumor arising in schwannoma. Rare Tumors. 2020;12:2036361320950862 Authors: Heatley N, Kolson Kokohaare E, Strauss DC, Hallin M, Jones RL, Fisher C, Thway K Abstract Epithelioid malignant peripheral nerve sheath tumor (EMPNST, malignant epithelioid schwannoma) is a rare variant of malignant peripheral nerve sheath tumor that has morphologic and immunophenotypic overlap with a variety of epithelioid...
Sat Sep 12, 2020 13:48
Contemporary trends in percutaneous renal mass biopsy utilization in the United States. Urol Oncol. 2020 Sep 07;: Authors: Ozambela M, Wang Y, Leow JJ, Silverman SG, Chung BI, Chang SL Abstract INTRODUCTION: Patients with a renal mass traditionally proceed directly to surgery without a preoperative tissue diagnosis confirming malignancy. Many surgically treated renal masses represent benign tumors or indolent malignancies on final pathology....
Sat Sep 12, 2020 13:48
Primary adenoid cystic carcinoma arising from an ectopic lacrimal gland involving both nasal orbits: a rare clinical entity. Orbit. 2020 Sep 10;:1-4 Authors: Nava-Castañeda Á, Kahuam-López N, De La Fuente Díez Y, Velásco Y Levy A, Sánchez-Bonilla FG, Martín F, Garnica-Hayashi L, Rodriguez-Reyes A Abstract Adenoid cystic carcinoma (ACC) is a slow-growing, locally invasive tumor of epithelial origin. The common sites of origin are the minor and...
Sat Sep 12, 2020 13:48
The Role of Non-Coding RNAs as Prognostic Factor, Predictor of Drug Response or Resistance and Pharmacological Targets, in the Cutaneous Squamous Cell Carcinoma. Cancers (Basel). 2020 Sep 08;12(9): Authors: Garofoli M, Volpicella M, Guida M, Porcelli L, Azzariti A Abstract Cutaneous squamous cell carcinoma (CSCC) is the most common keratinocyte-derived skin cancer in the Caucasian population. Exposure to UV radiations (UVRs) represents the...
Sat Sep 12, 2020 13:48
Related Articles [Thoracic Intraspinal Ganglioneuroma with Cough as Its Main Symptom:Report of One Case]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2020 Aug 30;42(4):566-569 Authors: Yan S, Feng HW, Cao LQ, Feng Q Abstract The ganglioneuroma is a benign tumor originating from sympathetic ganglion cells.It often locates in the posterior mediastinum,retroperitoneum,and adrenal medulla.The intraspinal ganglioneuromas is relatively rare in clinical practice,which...
Sat Sep 12, 2020 13:48
Related Articles [Clinicopathological Features of Follicular Dendritic Cell Sarcoma]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2020 Aug 30;42(4):504-512 Authors: Lu Y, Liu QL, Lu T, Pang JY, Huo Z Abstract Objective To explore the clinicopathological and immunohistochemical characteristics of follicular dendritic cell sarcoma(FDCS)and the expressions of IgG and IgG4. Methods We retrospectively analyzed the clinicopathological and immunohistochemical...
Sat Sep 12, 2020 13:48
Related Articles Update on the psychometric properties and minimal important difference (MID) thresholds of the FACT-M questionnaire for use in treatment-naïve and previously treated patients with metastatic Merkel cell carcinoma. Health Qual Life Outcomes. 2020 May 19;18(1):145 Authors: Bharmal M, Nolte S, Henry-Szatkowski M, Hennessy M, Schlichting M Abstract OBJECTIVES: For valid and reliable assessment of patients' Health-Related Quality...
Sat Sep 12, 2020 13:48
Related Articles Osteochondroma of the temporal styloid process: a common disease in a rare but vulnerable location. Clin Imaging. 2020 Sep;65:5-7 Authors: Chaturvedi R, Lin GY, Wang W, Smitaman E Abstract Osteochondromas, the most common benign bone tumor, are typically asymptomatic and discovered incidentally by imaging. Most frequently, osteochondromas occur at the metaphyses of long bones, and rarely involve the head and neck. We report...
Sat Sep 12, 2020 13:48
Related Articles Tumour response to TRK inhibition in a patient with pancreatic adenocarcinoma harbouring an NTRK gene fusion. Ann Oncol. 2019 11;30 Suppl 8:viii36-viii40 Authors: O'Reilly EM, Hechtman JF Abstract BACKGROUND: Although rare, NTRK gene fusions are known to be oncogenic drivers in pancreatic ductal adenocarcinoma (PDAC). We report the response of a metastatic CTRC-NTRK1 gene fusion-positive PDAC to targeted treatment with the...
Sat Sep 12, 2020 13:48
Related Articles Presence and predictors of anxiety disorder onset following cancer diagnosis among anxious cancer survivors. Support Care Cancer. 2020 Sep;28(9):4425-4433 Authors: Arch JJ, Genung SR, Ferris MC, Kirk A, Slivjak ET, Fishbein JN, Schneider RL, Stanton AL Abstract PURPOSE: Despite cancer survivors' frequent endorsement of anxiety symptoms, assessing the full range of anxiety disorders (AD), their timing of onset relative to cancer...
Sat Sep 12, 2020 13:48
Related Articles NKT-Like (CD3+CD56+) Cells in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors. Front Immunol. 2019;10:2493 Authors: Almeida JS, Couceiro P, López-Sejas N, Alves V, Růžičková L, Tarazona R, Solana R, Freitas-Tavares P, Santos-Rosa M, Rodrigues-Santos P Abstract Therapy with Tyrosine Kinase Inhibitors (TKI) aiming stable deep molecular response is the gold standard to treat Chronic Myeloid Leukemia...
Sat Sep 12, 2020 13:48
Related Articles Coexistence of Type-1 Diabetes Mellitus and Papillary Thyroid Carcinoma. Curr Diabetes Rev. 2020;16(7):787-789 Authors: Calapkulu M, Sencar ME, Duger H, Bayram SM, Unsal IO, Cakal E, Ozbek M Abstract İntroduction: Type 1 diabetes mellitus (DM) is characterized by selective autoimmune destruction of pancreatic b-cells, resulting in insulin deficiency and associated autoimmune disorders, such as celiac disease, autoimmune thyroiditis,...
Sat Sep 12, 2020 13:48
Related Articles MnFe2O4-decorated large-pore mesoporous silica-coated upconversion nanoparticles for near-infrared light-induced and O2 self-sufficient photodynamic therapy. Nanoscale. 2019 Aug 08;11(31):14654-14667 Authors: Ding B, Shao S, Xiao H, Sun C, Cai X, Jiang F, Zhao X, Ma P, Lin J Abstract The limited light penetration depth and tumor hypoxia are two natural shortcomings of photodynamic therapy (PDT). Overcoming these two issues...
Sat Sep 12, 2020 13:48
Related Articles Recurrence factors in pediatric ameloblastoma: Clinical features and a new classification system. Head Neck. 2019 10;41(10):3491-3498 Authors: Yang R, Tang Y, Zhang X, Liu Z, Gokavarapu S, Lin C, Ren Z, Zhou Y, Cao W, Ji T Abstract BACKGROUND: Ameloblastomas of jaw in the pediatric population are a rare clinical entity and have not been well addressed in the literatures. The present retrospective study analyzed the risk factors...
Sat Sep 12, 2020 13:48
Related Articles MANAGEMENT OF RETINAL HEMANGIOBLASTOMA IN VON HIPPEL-LINDAU DISEASE. Retina. 2019 Dec;39(12):2254-2263 Authors: Wiley HE, Krivosic V, Gaudric A, Gorin MB, Shields C, Shields J, Aronow ME, Chew EY Abstract PURPOSE: To review the current state of diagnosis and management of retinal hemangioblastoma and retinal vascular proliferation arising from von Hippel-Lindau (VHL) disease. METHODS: A review of the literature was...
Sat Sep 12, 2020 13:48
Related Articles Post-transplant primary central nervous system lymphoma after Epstein-Barr virus cerebellitis. J Neurovirol. 2019 04;25(2):280-283 Authors: Valencia-Sanchez C, Steenerson KK, Kelemen K, Orenstein R, Kusne S, Grill MF Abstract Post-transplantation lymphoproliferative disorder (PTLD) is a complication of solid organ and hematopoietic stem cell transplantation. Cases with isolated central nervous system (CNS) disease are rare....
Sat Sep 12, 2020 13:48
Related Articles miR‑124 targets retinoid X receptor α to reduce growth of TSC2‑deficient lymphangioleiomyomatosis. Oncol Rep. 2019 Feb;41(2):1342-1350 Authors: Liu J, Yuan J, Feng T, Zhao Y, Sun Q, Chen J, Chen J, Jin M, Xue B Abstract Lymphangioleiomyomatosis (LAM) is a rare neoplastic disease that leads to progressive destruction of lung function. However, the mechanisms underlying the progression of LAM remain unknown. Recent studies demonstrated...
Sat Sep 12, 2020 13:48
Related Articles The man who lost his body: Suboptimal multisensory integration yields body awareness problems after a right temporoparietal brain tumour. J Neuropsychol. 2019 09;13(3):603-612 Authors: Smit M, Van Stralen HE, Van den Munckhof B, Snijders TJ, Dijkerman HC Abstract Reports on patients who lack ownership over their entire body are extremely rare. Here, we present patient SA who suffered from complete body disownership after a...
Sat Sep 12, 2020 13:48
Lactic acid bacteria (LAB) are widely known for their probiotic activities for centuries. These bacteria synthesise some secretory proteinaceous toxins, bacteriocins, which help destroy similar or interrelated bacterial strains. This study was aimed at characterising bacteriocins extracted from Lactobacillus spp. found in yoghurt and assessing their bactericidal effect on foodborne bacteria. Twelve isolated Lactobacillus spp. were examined to produce bacteriocins by the organic solvent extraction...
Sat Sep 12, 2020 11:05
This study investigated if intestinal Clostridioides difficile (CD) causes liver injury. Four-week-old male C3H/HeN mice were treated with phosphate-buffered solution (control), CD, diethylnitrosamine (DEN) to induce liver injury with PBS (DEN+PBS), and DEN with CD (DEN+CD) for nine weeks. After sacrifice, livers and mesenteric lymph nodes (MLNs) were removed and bacterial translocation, transcriptomes, and proteins were analysed. CD was found in 20% of MLNs from the control and DEN+PBS groups, in...
Sat Sep 12, 2020 10:50
Publication date: Available online 12 September 2020Source: CortexAuthor(s): Emmanuel Mandonnet, Marion Vincent, Antoni Valero-Cabré, Valentine Facque, Marion Barberis, François Bonnetblanc, François Rheault, Emmanuelle Volle, Maxime Descoteaux, Daniel S. Margulies
Sat Sep 12, 2020 13:43
Novel anticancer therapy in BCG unresponsive non-muscle-invasive bladder cancer. Expert Rev Anticancer Ther. 2020 Sep 11;: Authors: Moussa M, Papatsoris AG, Dellis A, Abou Chakra M, Saad W Abstract INTRODUCTION: Many patients with non-muscle-invasive bladder cancer (NMIBC) failed intravesical BCG therapy. Currently, radical cystectomy is the recommended standard of care for those patients. There is unfortunately no effective other second-line...
Sat Sep 12, 2020 13:42
Distinguishing multiple lung primaries from intra-pulmonary metastases and treatment implications. Expert Rev Anticancer Ther. 2020 Sep 11;: Authors: Voulaz E, Novellis P, Rossetti F, Solinas M, Rossi S, Alloisio M, Pelosi G, Veronesi G Abstract INTRODUCTION: The distinction between multiple primary lung cancers and intra-pulmonary metastases has been extensively investigated because of its important clinical and therapeutic implications. ...
Sat Sep 12, 2020 13:42
Anti-cancer effect of miR-139-3p on laryngeal squamous cell carcinoma by targeting rab5a: In vitro and in vivo studies. Pathol Res Pract. 2020 Aug 31;216(11):153194 Authors: Ma Y, Gong Z, Wang H, Liang Y, Huang X, Yu G Abstract BACKGROUND: Laryngeal squamous cell carcinoma is the second most common head and neck squamous cell carcinoma. Nowadays, as traditional treatment methods are gradually limited, the development of new treatment methods...
Sat Sep 12, 2020 13:36
Hydroxy-corrole and its gallium(III) complex as new photosensitizer for photodynamic therapy against breast carcinoma. Eur J Med Chem. 2020 Sep 02;208:112794 Authors: Sun YM, Jiang X, Liu ZY, Liu LG, Liao YH, Zeng L, Ye Y, Liu HY Abstract Three mono-hydroxy corroles 1-3 and their gallium(III) complexes Ga1-3 were synthesized, and their photodynamic antitumour activities towards breast cancer cells were investigated. All corroles showed excellent...
Sat Sep 12, 2020 13:36
Homeostatic Control of Meiotic Prophase Checkpoint Function by Pch2 and Hop1. Curr Biol. 2020 Sep 02;: Authors: Raina VB, Vader G Abstract Checkpoint cascades link cell cycle progression with essential chromosomal processes. During meiotic prophase, recombination and chromosome synapsis are monitored by what are considered distinct checkpoints. In budding yeast, cells that lack the AAA+ ATPase Pch2 show an impaired cell cycle arrest in response...
Sat Sep 12, 2020 13:36
Anti-inflammatory treatment rescues memory deficits during aging in nfkb1-/- mice. Aging Cell. 2020 Sep 11;:e13188 Authors: Fielder E, Tweedy C, Wilson C, Oakley F, LeBeau FEN, Passos JF, Mann DA, von Zglinicki T, Jurk D Abstract Chronic inflammation is a common feature of many age-related conditions including neurodegenerative diseases such as Alzheimer's disease. Cellular senescence is a state of irreversible cell-cycle arrest, thought to...
Sat Sep 12, 2020 13:36
Pancreatic cancer drug-sensitivity predicted by synergy of p53-Activator Wnt Inhibitor-2 (PAWI-2) and protein biomarker expression. Invest New Drugs. 2020 Sep 11;: Authors: Cheng J, Cashman JR Abstract Today, pancreatic cancer (PC) is a major health problem in the United States. It remains a challenge to develop efficacious clinically useful PC therapies. New avenues, based on translational approaches and innovative validated biomarkers could...
Sat Sep 12, 2020 13:36
Cell Cycle Regulation by Berberine in Human Melanoma A375 Cells. Bull Exp Biol Med. 2020 Sep 11;: Authors: Ren M, Yang L, Li D, Yang L, Su Y, Su X Abstract We studied the effects of berberine on the proliferation, apoptosis, and migration of skin melanoma A375 cells, as well as cell cycle-related miRNAs and their target genes, CDK1, CDK2, and cyclins D1 and A. The inhibitory effect of berberine on the growth of A375 cells was evaluated by MTT...
Sat Sep 12, 2020 13:36
KLF14 inhibits osteogenic differentiation of human bone marrow mesenchymal stem cells by downregulating WNT3A. Am J Transl Res. 2020;12(8):4445-4455 Authors: Weng J, Wu J, Chen W, Fan H, Liu H Abstract KLF14 belongs to the Krüppel-like factor (KLF) family of transcription factors. The KLF family activate and/or repress transcription in a promoter- and cell-dependent manner by interacting with co-suppressors or co-activators. However, the function...
Sat Sep 12, 2020 13:36
Rho-kinase inhibition by Fasudil promotes tumor maturation and apoptosis in small-cell lung cancer. Am J Transl Res. 2020;12(8):4354-4370 Authors: Huo Z, Su Y, Dong Y, Zheng Y, Zhang Q, Duan Y, Wang G Abstract Small-cell lung cancer (SCLC) is a poorly differentiated neuroendocrine neoplasm with inadequate therapeutic options. Fasudil is a Rho-associated protein kinase 1 and 2 (ROCK1/2) inhibitor whose clinical indications remain limited in...
Sat Sep 12, 2020 13:36
SPR064, a pro-drug of paclitaxel, has anti-tumorigenic effects in endometrial cancer cell lines and mouse models. Am J Transl Res. 2020;12(8):4264-4276 Authors: Zhao X, Kong W, Tucker K, Staley A, Fan Y, Sun W, Yin Y, Huang Y, Fang Z, Wang J, Sen S, Dugar S, Zhou C, Bae-Jump VL Abstract Paclitaxel is one of the most effective and widely used agents in treating a variety of cancers, including endometrial cancer. Because of its poor solubility...
Sat Sep 12, 2020 13:36
Cytotoxicity and Preliminary Analysis of the Pro-apoptotic and Cell Cycle Arrest Effects of Lantana ukambensis Against Colorectal Cancer Cells. Int J Appl Biol Pharm. 2020;11(3):170-187 Authors: Sawadogo WR, Luo Y, Elkington B, He TC, Wang CZ, Yuan CS Abstract Lantana ukambensis (Vatke) Verdc. (Verbenaceae) is a seasonal herb widely spread in the West African region. The whole plant is used for the treatment of wounds, infections, and inflammatory...
Sat Sep 12, 2020 13:36
A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors. Bioorg Med Chem. 2020 Oct 01;28(19):115684 Authors: Barnes NG, Parker AW, Ahmed Mal Ullah AA, Ragazzon PA, Hadfield JA Abstract A series of combretastatin derivatives were designed and synthesised by a two-step stereoselective synthesis by use of Wittig olefination followed by Suzuki cross-coupling. Interestingly, all new compounds (2a-2i) showed...
Sat Sep 12, 2020 13:36
Impact of Wnt/β-Catenin Inhibition on Cell Proliferation through CDC25A Downregulation in Soft Tissue Sarcomas. Cancers (Basel). 2020 Sep 08;12(9): Authors: Martinez-Font E, Pérez-Capó M, Ramos R, Felipe I, Garcías C, Luna P, Terrasa J, Martín-Broto J, Vögler O, Alemany R, Obrador-Hevia A Abstract The Wnt signaling pathway is an important cellular mechanism for regulating differentiation processes as well as cell cycle events, and different...
Sat Sep 12, 2020 13:36
Targeting the Id1-Kif11 Axis in Triple-Negative Breast Cancer Using Combination Therapy. Biomolecules. 2020 Sep 08;10(9): Authors: Thankamony AP, Murali R, Karthikeyan N, Varghese BA, Teo WS, McFarland A, Roden DL, Holliday H, Konrad CV, Cazet A, Dodson E, Yang J, Baker LA, George JT, Levine H, Jolly MK, Swarbrick A, Nair R Abstract The basic helix-loop-helix (bHLH) transcription factors inhibitor of differentiation 1 (Id1) and inhibitor of...
Sat Sep 12, 2020 13:36
Role of Long-Term Vestibular Rehabilitation in a Patient with Posterior Fossa Tumor: A Case Report with 2 Years of Follow-Up. Am J Case Rep. 2020 Sep 11;21:e924262 Authors: Başoğlu Y, Yilmaz O, Çelik İ, Şerbetçioğlu MB Abstract BACKGROUND Lhermitte-Duclos disease (LDD) is caused by a rare slow-growing mass in the cerebellum. LDD generally is experienced by young adults, but also it has been encountered in the pediatric population. Lhermitte...
Sat Sep 12, 2020 13:33
Pancoast Tumor: The Overlooked Etiology of Shoulder Pain in Smokers. Am J Case Rep. 2020 Sep 11;21:e926643 Authors: Al Shammari M, Hassan A, Al Jawad M, Farea A, Almansour A, Al Yousif G, Sebiany A, Bin Bakr Z Abstract BACKGROUND Shoulder pain is a common complaint in general practice and typically has an orthopedic or rheumatological etiology. However, it may be the presenting symptom of a serious underlying condition, such as lung cancer....
Sat Sep 12, 2020 13:33
Advances in translational orthopaedic research with species-specific multipotent mesenchymal stromal cells derived from the umbilical cord. Histol Histopathol. 2020 Sep 11;:18249 Authors: Ramallo M, Carreras-Sánchez I, López-Fernández A, Vélez R, Aguirre M, Feldman S, Vives J Abstract Compliance with current regulations for the development of innovative medicines require the testing of candidate therapies in relevant translational animal models...
Sat Sep 12, 2020 13:33
Quantification of uric acid in vasculature of patients with gout using dual-energy computed tomography. World J Radiol. 2020 Aug 28;12(8):184-194 Authors: Barazani SH, Chi WW, Pyzik R, Chang H, Jacobi A, O'Donnell T, Fayad ZA, Ali Y, Mani V Abstract BACKGROUND: Gout, caused by hyperuricemia and subsequent deposition of aggregated monosodium urate crystals (MSU) in the joints or extra-articular regions, is the most common inflammatory arthritis....
Sat Sep 12, 2020 13:31
Sonographic evaluation of prostatic artery embolization: Far beyond size measurements. World J Radiol. 2020 Aug 28;12(8):172-183 Authors: Moschouris H, Dimakis A, Anagnostopoulou A, Stamatiou K, Malagari K Abstract Prostatic artery embolization (PAE) has gained acceptance as a minimally invasive, safe and effective treatment of symptomatic benign prostatic hyperplasia. Radiologic imaging is an indispensable part of post-interventional evaluation...
Sat Sep 12, 2020 13:31
Role for contrast-enhanced ultrasound in assessing complications after kidney transplant. World J Radiol. 2020 Aug 28;12(8):156-171 Authors: Como G, Da Re J, Adani GL, Zuiani C, Girometti R Abstract Kidney transplantation (KT) is an effective treatment for end-stage renal disease. Despite their rate has reduced over time, post-transplant complications still represent a major clinical problem because of the associated risk of graft failure and...
Sat Sep 12, 2020 13:31
Review of radiographic findings in COVID-19. World J Radiol. 2020 Aug 28;12(8):142-155 Authors: Kaufman AE, Naidu S, Ramachandran S, Kaufman DS, Fayad ZA, Mani V Abstract The purpose of this study is to review the published literature for the range of radiographic findings present in patients suffering from coronavirus disease 2019 infection. This novel corona virus is currently the cause of a worldwide pandemic. Pulmonary symptoms and signs...
Sat Sep 12, 2020 13:31
Insights into human cognition from intracranial EEG: A review of audition, memory, internal cognition, and causality. J Neural Eng. 2020 Sep 11;: Authors: Johnson E, Kam J, Tzovara A, Knight RT Abstract By recording neural activity directly from the human brain, researchers gain unprecedented insight into how neurocognitive processes unfold in real time. We first briefly discuss how intracranial electroencephalography (iEEG) recordings, performed...
Sat Sep 12, 2020 13:29
Thinker invariance: enabling deep neural networks for BCI across more people. J Neural Eng. 2020 Sep 11;: Authors: Kostas D, Rudzicz F Abstract OBJECTIVE: Most deep neural networks (DNNs) used as BCI classifiers are rarely viable for more than one person and are relatively shallow compared to the state-of-the-art in the wider machine learning literature. The goal of this work is to frame these as a unified challenge and reconsider how transfer...
Sat Sep 12, 2020 13:29
Chronic intracochlear electrical stimulation at high charge densities: Reducing platinum dissolution. J Neural Eng. 2020 Sep 11;: Authors: Shepherd RK, Carter P, Enke YL, Thompson A, Flynn B, Trang E, Dalrymple A, Fallon JB Abstract OBJECTIVE: Cochleae of long-term cochlear implant users have shown evidence of particulate platinum (Pt) corroded from the surface of Pt electrodes. The pathophysiological effect of Pt within the cochlea has not...
Sat Sep 12, 2020 13:29
Calcium imaging in freely-moving mice during electrical stimulation of deep brain structures. J Neural Eng. 2020 Sep 11;: Authors: Trevathan JK, Asp AJ, Nicolai EN, Trevathan J, Kremer NA, Kozai TDY, Cheng D, Schachter M, Nassi JJ, Otte SL, Parker JG, Lujan JL, Ludwig K Abstract After decades of study in humans and animal models, there remains a lack of consensus regarding how the action of electrical stimulation on neuronal and non-neuronal...
Sat Sep 12, 2020 13:29
Brief collaborative care intervention to reduce perceived unmet needs in highly distressed breast cancer patients: randomized controlled trial. Jpn J Clin Oncol. 2020 Sep 11;: Authors: Akechi T, Momino K, Katsuki F, Yamashita H, Sugiura H, Yoshimoto N, Wanifuchi-Endo Y, Toyama T Abstract OBJECTIVES: Our newly developed brief collaborative care intervention program has been suggested to be effective in reducing breast cancer patients' unmet...
Sat Sep 12, 2020 13:26
LINC00470 promotes tumour proliferation and invasion, and attenuates chemosensitivity through the LINC00470/miR-134/Myc/ABCC1 axis in glioma. J Cell Mol Med. 2020 Sep 11;: Authors: Wu C, Su J, Long W, Qin C, Wang X, Xiao K, Li Y, Xiao Q, Wang J, Pan Y, Liu Q Abstract Glioma is the most common primary malignant tumour in the brain; temozolomide (TMZ) is the most prevalent chemotherapeutic drug currently used to combat this cancer. We reported...
Sat Sep 12, 2020 13:26
The Evolution of Cerebral Language Localization: Historical Analysis and Current Trends. World Neurosurg. 2020 Sep 08;: Authors: Monroy-Sosa A, Chakravarthi SS, Cortes-Contreras AP, Hernandez-Varela M, Andres-Arrieta V, Epping A, Rovin RA Abstract Language localization has been an evolving concept over the past 150 years, with the emergence of several important yet conflicting ideologies. The Classical theory, starting from the phrenological...
Sat Sep 12, 2020 13:26
Extraprimary Local Recurrence of Esthesioneuroblastoma: Case Series and Literature Review. World Neurosurg. 2020 Sep 08;: Authors: Maina IW, Lehrich BM, Goshtasbi K, Su BM, Stubbs VC, Tong CCL, Kohanski MA, Lee JYK, Luu QC, Newman JG, Palmer JN, Adappa ND, Kuan EC Abstract OBJECTIVES: Esthesioneuroblastoma (ENB) is a rare sinonasal malignancy arising from olfactory neuroepithelium. Recurrence typically occurs locoregionally at the primary site...
Sat Sep 12, 2020 13:26
Magnetic resonance venography for 3-dimensional live guidance during venous sinus stenting. CVIR Endovasc. 2020 Sep 11;3(1):66 Authors: Kishore V, Sundararajan SH, Doustaly R, Michael M, Xuan D, Link T, Rapoport B, Patsalides A Abstract PURPOSE: The purpose of this study was to report the technique for intraprocedural guidance of endovascular Venous Sinus Stenting procedures using 3-Dimensional (3D) Magnetic Resonance Venography (MRV) as an...
Sat Sep 12, 2020 13:26
Multidisciplinary management of acromegaly: A consensus. Rev Endocr Metab Disord. 2020 Sep 10;: Authors: Giustina A, Barkhoudarian G, Beckers A, Ben-Shlomo A, Biermasz N, Biller B, Boguszewski C, Bolanowski M, Bollerslev J, Bonert V, Bronstein MD, Buchfelder M, Casanueva F, Chanson P, Clemmons D, Fleseriu M, Formenti AM, Freda P, Gadelha M, Geer E, Gurnell M, Heaney AP, Ho KKY, Ioachimescu AG, Lamberts S, Laws E, Losa M, Maffei P, Mamelak A, Mercado M, Molitch...
Sat Sep 12, 2020 13:26
Olfactory outcomes after endonasal skull base surgery: a systematic review. Neurosurg Rev. 2020 Sep 10;: Authors: Zhu J, Feng K, Tang C, Yang J, Cai X, Zhong C, Ma C Abstract For the last two decades, endonasal approach has been regularly applied to treat skull base lesions. However, postoperative olfactory dysfunction remains an unsolved problem. This systematic review aimed to identify factors that might affect postoperative olfactory prognosis...
Sat Sep 12, 2020 13:26
Cutaneous Carcinosarcoma: A Small Case Series and Review of the Literature of a Rare Skin Tumor. Cureus. 2020 Aug 05;12(8):e9569 Authors: Song EY, Wallace SJ, Sheikh H, Wojcik R, Nayak C Abstract Carcinosarcomas are composed of epithelial and mesenchymal elements and primarily present within visceral organs. Despite being potentially aggressive, they are a rare diagnosis in the skin, and few manifestations have been reported to date. In this...
Sat Sep 12, 2020 13:26
Sex and Genetic Background Effects on the Outcome of Experimental Intracranial Aneurysms. Stroke. 2020 Sep 11;:STROKEAHA120029651 Authors: Yanagisawa T, Zhang H, Suzuki T, Kamio Y, Takizawa T, Morais A, Chung DY, Qin T, Murayama Y, Faber JE, Patel AB, Ayata C Abstract BACKGROUND AND PURPOSE: Intracranial aneurysm formation and rupture risk are, in part, determined by genetic factors and sex. To examine their role, we compared 3 mouse strains...
Sat Sep 12, 2020 13:26
[Technology and clinical application of detecting endolymphatic hydrops in Meniere's disease using gadolinium-enhanced MRI]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Sep 07;55(9):869-877 Authors: Zou J, Wang WQ, Dai CF, Shi HB, Liu AG, Chen LG, Li YH, Pan C, Hu Y, Lu JP, Wu H PMID: 32911894 [PubMed - in process]
Sat Sep 12, 2020 13:26
[Surgery technique of combined different infratemporal fossa approaches for lesions in lateral skull base]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Sep 07;55(9):814-821 Authors: Wei XM, Gao ZQ, Xu ZQ, Yang H, Zhang ZH, Tian X, Zhao Y, Zhou YL, Feng GD Abstract Objective: To investigate the technical points and clinical application of combined infratemporal fossa approaches (CIFA) by analyzing the clinical results with CIFA for lesions...
Sat Sep 12, 2020 13:26
Related Articles Thinning or dehiscence of bone in structures of the middle cranial fossa floor in superior semicircular canal dehiscence. J Clin Neurosci. 2020 Apr;74:104-108 Authors: Arsenault JJ, Romiyo P, Miao T, Monteiro K, De Jong R, Kaur T, Johanis M, Duong C, Sheppard JP, Sun MZ, Ferraro R, Salamon N, Yang I, Gopen Q Abstract BACKGROUND: Superior semicircular canal dehiscence (SSCD) is a rare inner ear disorder; currently, it is unknown...
Sat Sep 12, 2020 13:26
The insulin-sensitizing effect of a single exercise bout is similar in type I and type II human muscle fibres. J Physiol. 2020 Sep 11;: Authors: Larsen MR, Steenberg DE, Birk JB, Sjøberg KA, Kiens B, Richter EA, Wojtaszewski JFP Abstract KEY POINTS: Rodent studies suggest muscle fibre type-specific insulin response in the recovery from exercise. The current study investigates muscle fibre type-specific insulin action in the recovery from...
Sat Sep 12, 2020 13:21
Subhepatic appendicitis is an exceedingly rare presentation, accounting for 0.01% of acute appendicitis cases. It is of prime importance to be aware of variants and manage such challenging cases accordingly.
Sat Sep 12, 2020 03:00
The role of dry mouth in screening sleep apnea. Postgrad Med J. 2020 Sep 10;: Authors: Zhang C, Shen Y, Liping F, Ma J, Wang GF Abstract PURPOSE OF THE STUDY: Effective screening questionnaires are essential for early detection of obstructive sleep apnea (OSA). The STOP-Bang questionnaire has high sensitivity but low specificity. Dry mouth is a typical clinical sign of OSA. We hypothesised that adding dry mouth in the STOP-Bang questionnaire...
Sat Sep 12, 2020 13:20
Related Articles Abnormal respiratory event detection in sleep: A prescreening system with smart wearables. J Biomed Inform. 2019 07;95:103218 Authors: Camcı B, Ersoy C, Kaynak H Abstract Sleeping is an important activity to monitor since it has a crucial role in the overall health and well-being of the people and society. In order to diagnose the problems in sleep, different monitoring systems are developed in the literature. The unobtrusiveness,...
Sat Sep 12, 2020 13:20
Publication date: Available online 12 September 2020Source: Journal of Surgical EducationAuthor(s): Muneera R Kapadia, Edmund Lee, Heather Healy, Jonathan M Dort, Marcy E Rosenbaum, Anna B Newcomb
Sat Sep 12, 2020 13:19
Publication date: Available online 12 September 2020Source: Journal of Surgical EducationAuthor(s): Grace S. Lee-Riddle, David F. Sigmon, Andrew D. Newton, Rachel R. Kelz, Kristoffel R. Dumon, Jon B. Morris
Sat Sep 12, 2020 13:19
Publication date: Available online 11 September 2020Source: Journal of Surgical EducationAuthor(s): Jenny Bui, William C. Bennett, Jason Long, Paula D. Strassle, Benjamin Haithcock
Sat Sep 12, 2020 13:19
Pemphigus encompasses a group of chronic autoimmune blistering diseases of the skin and/or mucosa. Rituximab (RTX) has shown promising efficacy for the treatment of pemphigus in the past decade. Considering potential cardiac side effects, this study was conducted to assess the effects of RTX on electrocardiogram (ECG) parameters in pemphigus patients. This observational cross‐sectional study was conducted in 80 consecutive patients with pemphigus who were eligible for RTX infusion. The patients'...
Fri Sep 11, 2020 19:38
Abstract Bromoderma is a rare hypersensitivity reaction caused by bromide intake. It was relatively frequent in the early years of the previous century because of the common use of bromide‐containing solutions in pediatricsdue to their antispasmodic, expectorant, sedative, and anticonvulsant effects. Although recently prohibited in many countries, bromides are still used as an adjuvant anticonvulsant drug and still present in some over the counter antispasmodics and analgesics. Bromoderma usually...
Fri Sep 11, 2020 19:28
Abstract The lips are considered of great importance for the perception of beauty and thereis still a lacuna in the attempt to successfully re‐pigment resistant areas of vitiligo especially the lips.Notechnique evolved so far ensures 100% pigmentation with a good cosmetic appearance. To study the efficacy and cosmetic outcome following primary excision and closure in the management of lip vitiligo and assessing postoperative morbidity using the created Surgical Site Morbidity Score (SSMS). Twenty‐five...
Fri Sep 11, 2020 17:05
Relationship between the Levels of mRNA Expression for Protein Phosphatase 1B and Proteins Involved in Cytoskeleton Remodeling in Squamous Cell Carcinoma of the Larynx and Hypopharynx. Bull Exp Biol Med. 2020 Sep 11;: Authors: Kakurina GV, Kolegova ES, Shashova EE, Velikaya VV, Startseva ZA, Cheremisina OV, Choinzonov EL, Kondakova IV Abstract We analyzed the expression of genes encoding proteins involved in cytoskeleton remodeling (RND3, SNAI1,...
Sat Sep 12, 2020 13:14
Long noncoding RNAs in head and neck squamous cell carcinoma: biological functions and mechanisms. Mol Biol Rep. 2020 Sep 10;: Authors: Zhao J, Liu D, Yang H, Yu S, He H Abstract Head and neck squamous cell carcinoma (HNSCC) is the primary malignant tumor of the oral cavity, larynx, nasopharynx, esophagus and tongue. Although several novel therapeutic methods for HNSCC have been developed, the final therapeutic effect on the patient is still...
Sat Sep 12, 2020 13:14
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