Related Articles Extended resection of a cardiac paraganglioma-A rare neuroendocrine manifestation of the heart. J Card Surg. 2020 Mar;35(3):700-702 Authors: Nemeth A, Schlensak C, Popov A Abstract BACKGROUND: Cardiac paragangliomas are rare tumors that develop from neural crest cells. They account for about 2% of all paragangliomas and there is only limited evidence of malignant transformation. CASE PRESENTATION: We present a young...
Sat Sep 12, 2020 09:36
Related Articles Follicular lymphoma presenting as hyperleucocytosis. BMJ Case Rep. 2020 Jan 21;13(1): Authors: Worth HA, Cochrane K, Aljadir D Abstract Follicular lymphoma is the second most common subtype of non-Hodgkin's lymphoma affecting adults. Clinically, follicular lymphoma is generally indolent, most often presenting as a painless peripheral lymphadenopathy; however, a leucocytosis at presentation is exceedingly rare. We present the...
Sat Sep 12, 2020 09:36
Related Articles Postoperative Horner's syndrome following excision of incidental cervical ganglioneuroma during hemithyroidectomy and parathyroid gland exploration. BMJ Case Rep. 2020 Jan 21;13(1): Authors: McCrory D, Kelly A, Korda M Abstract This 49-year-old woman was referred to ear, nose and throat (ENT) with primary hyperparathyroidism. Imaging studies failed to localise the adenoma so she required four-gland parathyroid exploration....
Sat Sep 12, 2020 09:36
Related Articles Primary renal embryonal rhabdomyosarcoma in an adult patient. BMJ Case Rep. 2020 Jan 21;13(1): Authors: Connor J, Tsui JF, He W, Munver R Abstract Adult renal rhabdomyosarcoma (RMS) is a rare and aggressive entity with a paucity of data and reports in the literature. As a result, treatment guidelines for this malignancy are not well-established. Herein, we present the diagnosis, management and clinical course of a 39-year-old...
Sat Sep 12, 2020 09:36
Related Articles Pineal glioblastoma: Case report and literature review of an exceedingly rare etiology for pineal region mass. Clin Imaging. 2020 Mar;60(1):95-99 Authors: Sajan A, Hewitt K, Soleiman A, Velayudhan V Abstract Pineal glioblastoma is an exceedingly rare potential etiology for a pineal region mass. The presentation, imaging appearance, and changes in treatment have been documented in a select number of cases since its first description...
Sat Sep 12, 2020 09:36
Related Articles Acquired Resistance Mutations to ALK Inhibitors Identified by Single Circulating Tumor Cell Sequencing in ALK-Rearranged Non-Small-Cell Lung Cancer. Clin Cancer Res. 2019 11 15;25(22):6671-6682 Authors: Pailler E, Faugeroux V, Oulhen M, Mezquita L, Laporte M, Honoré A, Lecluse Y, Queffelec P, NgoCamus M, Nicotra C, Remon J, Lacroix L, Planchard D, Friboulet L, Besse B, Farace F Abstract PURPOSE: Patients with anaplastic lymphoma...
Sat Sep 12, 2020 09:36
Related Articles Long-term outcome of rare oncocytic papillary (Hürthle cell) thyroid carcinoma following (adjuvant) initial radioiodine therapy. Eur J Nucl Med Mol Imaging. 2019 Nov;46(12):2526-2535 Authors: Wenter V, Jellinek A, Unterrainer M, Ahmaddy F, Lehner S, Albert NL, Bartenstein P, Knösel T, Spitzweg C, Ilhan H, Todica A Abstract PURPOSE: Oncocytic (Hürthle cell) papillary thyroid carcinoma (OPTC) is a rare variant of the papillary...
Sat Sep 12, 2020 09:36
Related Articles Clinical characteristics and prognostic significance of chronic myeloid leukemia with rare BCR-ABL1 transcripts. Leuk Lymphoma. 2019 12;60(12):3051-3057 Authors: Xue M, Wang Q, Huo L, Wen L, Yang X, Wu Q, Pan J, Cen J, Ruan C, Wu D, Chen S Abstract The prognostic significance of rare BCR-ABL1 transcripts is uncertain in the tyrosine kinase inhibitor (TKI) era. In this retrospective study, 40 (1.7%) patients with rare BCR-ABL1...
Sat Sep 12, 2020 09:36
Related Articles Blast crisis of chronic myeloid leukemia with plasmacytoid dendritic cell phenotype associated with a rare fusion transcript, e13a3 BCR-ABL1. Leuk Lymphoma. 2019 12;60(12):3090-3091 Authors: Xu D, Claudiani S, Naresh K, Mucklow S, Neelakantan P, Yebra E, Apperley JF, Khorashad J, Milojkovic D PMID: 31184233 [PubMed - indexed for MEDLINE]
Sat Sep 12, 2020 09:36
Related Articles Construction of a Robust Entropy-Driven DNA Nanomachine for Single-Molecule Detection of Rare Cancer Cells. Anal Chem. 2019 06 18;91(12):7505-7509 Authors: Ma F, Wei SH, Zhang CY Abstract Accurate and sensitive detection of rare cancer cells such as circulating tumor cells (CTCs) has attracted great interest in the fields of clinical diagnosis and cancer research. However, the reported methods for cancer cell detection often...
Sat Sep 12, 2020 09:36
Related Articles Epidermolysis bullosa: Advances in research and treatment. Exp Dermatol. 2019 10;28(10):1176-1189 Authors: Prodinger C, Reichelt J, Bauer JW, Laimer M Abstract Epidermolysis bullosa (EB) is the umbrella term for a group of rare inherited skin fragility disorders caused by mutations in at least 20 different genes. There is no cure for any of the subtypes of EB resulting from different mutations, and current therapy only focuses...
Sat Sep 12, 2020 09:36
Related Articles Effect of leucovorin administration on mucositis and skin reactions in patients with peripheral T-cell lymphoma or cutaneous T-cell lymphoma treated with pralatrexate. Leuk Lymphoma. 2019 12;60(12):2927-2930 Authors: Foss FM, Parker TL, Girardi M, Li A Abstract Peripheral T-cell lymphoma (PTCL) and cutaneous T-cell lymphoma (CTCL) are rare, heterogeneous non-Hodgkin lymphomas with poor prognoses. Pralatrexate has demonstrated...
Sat Sep 12, 2020 09:36
Related Articles Construction of lanthanide-doped upconversion nanoparticle-Uelx Europaeus Agglutinin-I bioconjugates with brightness red emission for ultrasensitive in vivo imaging of colorectal tumor. Biomaterials. 2019 08;212:64-72 Authors: Tian R, Zhao S, Liu G, Chen H, Ma L, You H, Liu C, Wang Z Abstract Lanthanide-doped upconversion nanoparticles (UCNPs)-based active targeting optical bioimaging has attracted tremendous scientific interest...
Sat Sep 12, 2020 09:36
Related Articles Multiplex Enrichment and Detection of Rare KRAS Mutations in Liquid Biopsy Samples using Digital Droplet Pre-Amplification. Anal Chem. 2019 06 18;91(12):7516-7523 Authors: Pratt ED, Cowan RW, Manning SL, Qiao E, Cameron H, Schradle K, Simeone DM, Zhen DB Abstract Oncology research is increasingly incorporating molecular detection of circulating tumor DNA (ctDNA) as a tool for cancer surveillance and early detection. However,...
Sat Sep 12, 2020 09:36
Brain necrosis in adult patients after proton therapy: Is there evidence for dependency on linear energy transfer (LET)? Int J Radiat Oncol Biol Phys. 2020 Sep 07;: Authors: Niemierko A, Schuemann J, Niyazi M, Giantsoudi D, Maquilan G, Shih HA, Paganetti H Abstract PURPOSE: To investigate if radiographic imaging changes defined as necrosis correlate with regions in the brain with elevated linear energy transfer (LET) for proton radiation therapy...
Sat Sep 12, 2020 09:29
Outcome and Complications of Frontal Sinus Stenting: A Case Presentation and Literature Review. Case Rep Otolaryngol. 2020;2020:8885870 Authors: Khan MA, Alshareef WA, Marglani OA, Herzallah IR Abstract Introduction: Frontal sinus surgery remains challenging to manage because of its complex anatomy and narrow outflow tract. A number of studies suggest the success of frontal sinus stenting to reduce postoperative complications in endoscopic...
Sat Sep 12, 2020 09:29
Related Articles Posterior Fossa Arteriovenous Malformations: Experience with 14 Patients and a Systematic Review of the Literature. J Neurol Surg A Cent Eur Neurosurg. 2020 Mar;81(2):170-176 Authors: Corniola MV, Meling TR, Bijlenga P, Bernava G, Machi P, Schaller K Abstract BACKGROUND: The optimal management of posterior fossa arteriovenous malformations (pfAVMs) is a matter of debate. To advance this discussion, we present our clinical series...
Sat Sep 12, 2020 09:29
Topical Triamcinolone on "Sweet Spots" to Block Dynamic Pain after Tonsillectomy and Uvulo-Palato-Pharyngo-Plasty. Ann Otol Rhinol Laryngol. 2020 Sep 10;:3489420953602 Authors: Chen JK, Niddam DM, Tung TH, Li LP Abstract OBJECTIVES: Severe pain on swallowing (or dynamic pain) has long been a problem in patients receiving tonsillectomy and uvulopalatopharyngoplasty for the treatment of obstructive sleep apnea syndrome and/or snoring. We have...
Sat Sep 12, 2020 09:16
Related Articles Coronavirus Disease 2019 Return to Work Guidance and Recommendations for Vestibular Clinicians. Ear Hear. 2020 Jul/Aug;41(4):693-696 Authors: Rizk HG, Strange C, Atallah S, Massingale S, Clendaniel R Abstract As states begin issuing progressive deconfinement guidelines, hospitals and institutions are starting to reopen for elective procedures and consultations. Vestibular clinicians are opening their practices to evaluate,...
Sat Sep 12, 2020 09:13
Related Articles Impact of Stimulus Polarity on oVEMP Response Using the Belly-Tendon Electrode Montage. J Am Acad Audiol. 2019 05;30(5):357-362 Authors: Romero DJ, Kitner BH, Wilson MJ, Smith KJ Abstract BACKGROUND: One stimulus parameter not well established with respect to the ocular vestibular evoked myogenic potential (oVEMP) is stimulus polarity. Many research studies traditionally record oVEMPs using alternating polarity primarily....
Sat Sep 12, 2020 09:13
Diagnostic considerations prior to pediatric tracheocutaneous fistula closure. Int J Pediatr Otorhinolaryngol. 2020 Sep 01;138:110357 Authors: Chorney SR, Husain S, Sobol SE Abstract INTRODUCTION: An airway assessment often occurs prior to tracheocutaneous fistula (TCF) closure in children. Bronchoscopy (MLB) with or without fistula-occluded polysomnography (PSG) helps determine candidacy and localize potential obstruction. To date, little...
Sat Sep 12, 2020 09:09
Mucosa-Associated Lymphoid Tissue Lymphoma of the Larynx. Case Rep Otolaryngol. 2020;2020:8703921 Authors: Rizvi O, Nielsen T, Bearelly S Abstract Background: Mucosa-associated lymphoid tissue (MALT) lymphomas are a subtype of non-Hodgkin lymphoma stemming from marginal zone B-cells. In this case report, we present two patients with an extremely rare localization of MALT lymphoma to the larynx. Methods: Case 1 is of a 78-year-old male...
Sat Sep 12, 2020 09:09
Related Articles Indiscriminate Pathologic Examination of Pediatric Supraglottoplasty Specimens: An Evidence-Based Approach toward Exempt Status. Otolaryngol Head Neck Surg. 2020 Aug;163(2):194-197 Authors: Elghouche AN, Alwani MM, Matt BH Abstract OBJECTIVE: The primary aim of this study was to demonstrate that indiscriminate pathologic evaluation of supraglottoplasty specimens is unnecessary and does not influence postoperative management....
Sat Sep 12, 2020 09:09
Related Articles Corner vowels in males and females ages 4 to 20 years: Fundamental and F1-F4 formant frequencies. J Acoust Soc Am. 2019 11;146(5):3255 Authors: Vorperian HK, Kent RD, Lee Y, Bolt DM Abstract The purpose of this study was to determine the developmental trajectory of the four corner vowels' fundamental frequency (fo) and the first four formant frequencies (F1-F4), and to assess when speaker-sex differences emerge. Five words...
Sat Sep 12, 2020 09:09
Related Articles Effect of changes in medial surface shape on voice production in excised human larynges. J Acoust Soc Am. 2019 11;146(5):EL412 Authors: Zhang Z, Chhetri DK Abstract Clinical intervention of glottal insufficiency often focuses on correcting glottal gap as visualized from above. In contrast, changes in medial surface shape due to intervention have received less attention. This study investigated how changes in medial surface...
Sat Sep 12, 2020 09:09
Molecular regulation of ZmMs7 required for maize male fertility and development of a dominant male-sterility system in multiple species. Proc Natl Acad Sci U S A. 2020 Sep 09;: Authors: An X, Ma B, Duan M, Dong Z, Liu R, Yuan D, Hou Q, Wu S, Zhang D, Liu D, Yu D, Zhang Y, Xie K, Zhu T, Li Z, Zhang S, Tian Y, Liu C, Li J, Yuan L, Wan X Abstract Understanding the molecular basis of male sterility and developing practical male-sterility systems...
Sat Sep 12, 2020 09:02
Structure-function studies of Rgg binding to pheromones and target promoters reveal a model of transcription factor interplay. Proc Natl Acad Sci U S A. 2020 Sep 09;: Authors: Capodagli GC, Tylor KM, Kaelber JT, Petrou VI, Federle MJ, Neiditch MB Abstract Regulator gene of glucosyltransferase (Rgg) family proteins, such as Rgg2 and Rgg3, have emerged as primary quorum-sensing regulated transcription factors in Streptococcus species, controlling...
Sat Sep 12, 2020 09:02
Human norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids. Proc Natl Acad Sci U S A. 2020 Sep 09;: Authors: Lin SC, Qu L, Ettayebi K, Crawford SE, Blutt SE, Robertson MJ, Zeng XL, Tenge VR, Ayyar BV, Karandikar UC, Yu X, Coarfa C, Atmar RL, Ramani S, Estes MK Abstract Human noroviruses (HuNoVs) are the leading cause of viral gastroenteritis worldwide; yet currently, no vaccines or FDA-approved...
Sat Sep 12, 2020 09:02
Clathrin light chain diversity regulates membrane deformation in vitro and synaptic vesicle formation in vivo. Proc Natl Acad Sci U S A. 2020 Sep 09;: Authors: Redlingshöfer L, McLeod F, Chen Y, Camus MD, Burden JJ, Palomer E, Briant K, Dannhauser PN, Salinas PC, Brodsky FM Abstract Clathrin light chain (CLC) subunits in vertebrates are encoded by paralogous genes CLTA and CLTB, and both gene products are alternatively spliced in neurons. To...
Sat Sep 12, 2020 09:02
A conserved subcomplex within the bacterial cytokinetic ring activates cell wall synthesis by the FtsW-FtsI synthase. Proc Natl Acad Sci U S A. 2020 Sep 09;: Authors: Marmont LS, Bernhardt TG Abstract Cell division in bacteria is mediated by a multiprotein assembly called the divisome. A major function of this machinery is the synthesis of the peptidoglycan (PG) cell wall that caps the daughter poles and prevents osmotic lysis of the newborn...
Sat Sep 12, 2020 09:02
LncRNA Malat1 inhibition of TDP43 cleavage suppresses IRF3-initiated antiviral innate immunity. Proc Natl Acad Sci U S A. 2020 Sep 09;: Authors: Liu W, Wang Z, Liu L, Yang Z, Liu S, Ma Z, Liu Y, Ma Y, Zhang L, Zhang X, Jiang M, Cao X Abstract Long noncoding RNAs (lncRNAs) involved in the regulation of antiviral innate immune responses need to be further identified. By functionally screening the lncRNAs in macrophages, here we identified lncRNA...
Sat Sep 12, 2020 09:02
Records of RNA locations in living yeast revealed through covalent marks. Proc Natl Acad Sci U S A. 2020 Sep 09;: Authors: Medina-Munoz HC, Lapointe CP, Porter DF, Wickens M Abstract RNA movements and localization pervade biology, from embryonic development to disease. To identify RNAs at specific locations, we developed a strategy in which a uridine-adding enzyme is anchored to subcellular sites, where it directly marks RNAs with 3' terminal...
Sat Sep 12, 2020 09:02
A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade. Proc Natl Acad Sci U S A. 2020 Sep 09;: Authors: Chen IX, Newcomer K, Pauken KE, Juneja VR, Naxerova K, Wu MW, Pinter M, Sen DR, Singer M, Sharpe AH, Jain RK Abstract Immune checkpoint blockade (ICB) is efficacious in many diverse cancer types, but not all patients respond. It is important to understand the mechanisms...
Sat Sep 12, 2020 09:02
Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch. Proc Natl Acad Sci U S A. 2020 Sep 09;: Authors: Gaubitz C, Liu X, Magrino J, Stone NP, Landeck J, Hedglin M, Kelch BA Abstract DNA replication requires the sliding clamp, a ring-shaped protein complex that encircles DNA, where it acts as an essential cofactor for DNA polymerases and other proteins. The sliding clamp needs to be opened...
Sat Sep 12, 2020 09:02
Neural progenitor cell pyroptosis contributes to Zika virus-induced brain atrophy and represents a therapeutic target. Proc Natl Acad Sci U S A. 2020 Sep 09;: Authors: He Z, An S, Chen J, Zhang S, Tan C, Yu J, Ye H, Wu Y, Yuan J, Wu J, Zhu X, Li M Abstract Mounting evidence has associated Zika virus (ZIKV) infection with congenital malformations, including microcephaly, which raises global alarm. Nonetheless, mechanisms by which ZIKV disrupts...
Sat Sep 12, 2020 09:02
Spatially dependent H-bond dynamics at interfaces of water/biomimetic self-assembled lattice materials. Proc Natl Acad Sci U S A. 2020 Sep 09;: Authors: Wang H, Wagner JC, Chen W, Wang C, Xiong W Abstract Understanding hydrogen-bond interactions in self-assembled lattice materials is crucial for preparing such materials, but the role of hydrogen bonds (H bonds) remains unclear. To gain insight into H-bond interactions at the materials' intrinsic...
Sat Sep 12, 2020 09:02
Dynamic structural order of a low-complexity domain facilitates assembly of intermediate filaments. Proc Natl Acad Sci U S A. 2020 Sep 09;: Authors: Sysoev VO, Kato M, Sutherland L, Hu R, McKnight SL, Murray DT Abstract The coiled-coil domains of intermediate filament (IF) proteins are flanked by regions of low sequence complexity. Whereas IF coiled-coil domains assume dimeric and tetrameric conformations on their own, maturation of eight tetramers...
Sat Sep 12, 2020 09:02
Core Concept: Nascent exascale supercomputers offer promise, present challenges. Proc Natl Acad Sci U S A. 2020 Sep 09;: Authors: Mann A PMID: 32907934 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 09:02
Circulation of gut-preactivated naïve CD8+ T cells enhances antitumor immunity in B cell-defective mice. Proc Natl Acad Sci U S A. 2020 Sep 09;: Authors: Akrami M, Menzies R, Chamoto K, Miyajima M, Suzuki R, Sato H, Nishii A, Tomura M, Fagarasan S, Honjo T Abstract The gut microbiome has garnered attention as an effective target to boost immunity and improve cancer immunotherapy. We found that B cell-defective (BCD) mice, such as µ-membrane...
Sat Sep 12, 2020 09:02
Exposure to pyrethroids induces behavioral impairments, neurofibrillary tangles and tau pathology in Alzheimer's type neurodegeneration in adult Wistar rats. Drug Chem Toxicol. 2020 Sep 09;:1-11 Authors: Iteire KA, Sowole AT, Ogunlade B Abstract This study investigated the exposure of pyrethroids in the development of Alzheimer's type neurodegeneration by analyzing β- amyloid, tau and Glial Fibrillary Acidic Protein (GFAP) in adult Wistar rats....
Sat Sep 12, 2020 08:58
Hepatotoxic effect of lead and hepatoprotective effect of Hydrilla verticillata on hepatic transcriptional and physiological response in edible fish Labeo rohita. Drug Chem Toxicol. 2020 Sep 09;:1-8 Authors: S PP, Rajkumar J, C K Abstract Lead tops the list of developmental toxicants released by industry into the environment according to Commission for Environmental Corporation. Hydrilla verticillata is an aquatic weed and rich source of variable...
Sat Sep 12, 2020 08:58
A survey has shown that audiologists feel the COVID-19 lockdown has brought about some beneficial changes to the care of patients with hearing problems.Dr. Gabrielle Saunders, a Senior Research Fellow at The University of Manchester says findings from the survey of 140 audiologists are a rare positive in the crisis which has caused misery across the world.The study, published in the International Journal of Audiology, estimates that between 29 May and 15 June, just 5% of face to face audiology appointments...
Fri Sep 11, 2020 12:33
COVID-19 lockdown learning: The revolution of virtual teaching. J Plast Reconstr Aesthet Surg. 2020 Aug 29;: Authors: Padley RH, Di Pace B PMID: 32907789 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 08:54
Abstract Background We conducted a phase 1 dose escalation study (ACTRN12618000140257 registered on 30/01/2018) to evaluate the safety, tolerability and immunogenicity of a therapeutic human papillomavirus (HPV) DNA vaccine (AMV002) in subjects previously treated for HPV-associated oropharyngeal squamous cell carcinoma (OPSCC). Methods Eligible subjects...
Sat Sep 12, 2020 03:00
Should adults with isolated serous otitis media be undergoing routine biopsies of the post-nasal space? J Laryngol Otol. 2020 Sep 10;:1-3 Authors: Cunniffe HA, Gona AK, Phillips JS Abstract BACKGROUND: Serous otitis media is a recognised presentation of Eustachian tube dysfunction secondary to post-nasal space pathology. Post-nasal space biopsies are commonly taken in patients with isolated serous otitis media, despite normal nasendoscopy findings,...
Sat Sep 12, 2020 08:45
Age-Dependent Reduction in Severity and Discrete Topographical Patterns in Rasmussen Encephalitis: A Link to Cortical Maturation? Pediatr Neurol. 2020 Aug 11;112:25-33 Authors: Benjamin RN, Thomas M, Muthusamy K, Yoganathan S, Mathew V, Chacko AG, Prabhu K, Chacko G Abstract BACKGROUND: Autopsy studies in Rasmussen encephalitis reveal areas of sparing within the affected hemisphere. Clinical progression and inflammation are milder with an older...
Sat Sep 12, 2020 08:43
Effects of perampanel add-on therapy on immunoglobulin levels in pediatric patients with epilepsy. Epilepsy Res. 2020 Aug 21;167:106447 Authors: Ishikawa N, Tateishi Y, Tani H, Kobayashi Y, Okada S Abstract BACKGROUND: Perampanel (PER) has a unique pharmacological mechanism and marked efficacy in both focal and generalized epilepsy, but may cause adverse events similar to those of other antiepileptic drugs (AEDs). AEDs can affect multiple organ...
Sat Sep 12, 2020 08:43
Increase in cognitive function is seen in many single-operated pediatric patients after epilepsy surgery. Seizure. 2020 Aug 28;81:254-262 Authors: de Knegt VE, Hoei-Hansen CE, Knudsen M, Jakobsen AV, Mûller E, Thomsen KM, Jespersen B, Uldall PV, Børresen ML Abstract PURPOSE: The recurrent seizures of pediatric drug-resistant epilepsy (DRE) are known to impair brain development and can lead to a loss in cognitive functioning. Surgery is increasingly...
Sat Sep 12, 2020 08:43
Electrical status epilepticus during sleep in patients with congenital Zika virus syndrome: An unprecedented clinical finding. Seizure. 2020 Aug 21;81:250-253 Authors: Krueger MB, Magalhães SC, Pessoa A, Bueno C, Masruha MR, Sobreira-Neto MA Abstract BACKGROUND: Brazil experienced a disproportionately higher rate of microcephaly cases in November 2015 with evidence of a causal link with Zika virus (ZIKV) infections during pregnancy. Epilepsy...
Sat Sep 12, 2020 08:43
Cardiac arrhythmias and sudden unexpected death in epilepsy: results of long-time monitoring. Heart Rhythm. 2020 Sep 07;: Authors: Serdyuk S, Davtyan K, Burd S, Drapkina O, Boytsov S, Gusev E, Topchyan A Abstract BACKGROUND: Cardiac rhythm and conduction disorders are common in patients with epilepsy and are presumably one of the leading causes of sudden unexpected death. There are only a few published reports on ictal cardiac arrhythmias detected...
Sat Sep 12, 2020 08:43
Cannabidiol inhibits multiple cardiac ion channels and shortens ventricular action potential duration in vitro. Eur J Pharmacol. 2020 Sep 07;:173542 Authors: Le Marois M, Ballet V, Sanson C, Maizières MA, Carriot T, Chantoiseau C, Partiseti M, Bohme GA Abstract Cannabidiol (CBD) is a non-psychoactive component of Cannabis which has recently received regulatory consideration for the treatment of intractable forms of epilepsy such as the Dravet...
Sat Sep 12, 2020 08:43
Coumaronochromone as antibacterial and carbonic anhydrase inhibitors from Aerva persica (Burm.f.) Merr.: experimental and first-principles approaches. Z Naturforsch C J Biosci. 2020 Sep 09;: Authors: Imran M, Irfan A, Assiri MA, Sumrra SH, Saleem M, Hussain R, Al-Sehemi AG Abstract The Aerva plants are exceptionally rich in phytochemicals and possess therapeutics potential. Phytochemical screening shows that Aerva persica (Burm.f.) Merr. contains...
Sat Sep 12, 2020 08:43
Levetiracetam Induced Behavioral Abnormalities in a Patient with Seizure Disorder: A Diagnostic Challenge. Case Rep Psychiatry. 2020;2020:8883802 Authors: Ogunsakin O, Tumenta T, Louis-Jean S, Mahbub A, Rabel P, Olupona T, Alam S Abstract Levetiracetam is a second-generation antiepileptic drug that is chemically unrelated to other antiepileptic drugs. Levetiracetam is a broad-spectrum antiseizure medication that is approved as an adjunctive...
Sat Sep 12, 2020 08:43
Letter to the Editor Regarding "Neuroinflammation in Children With Infantile Spasms: A Prospective Study Before and After Treatment with Acthar Gel (Repository Corticotropin Injection)". J Child Neurol. 2020 Sep 09;:883073820956769 Authors: Jiong Y, Hui Y PMID: 32907445 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 08:43
Related Articles Acute Hemorrhage After Intracerebral Biopsy in COVID-19 Patients: Report of 3 Cases. World Neurosurg. 2020 09;141:157-161 Authors: Degeneffe A, Bruneau M, Spitaels J, Gilis N, De Witte O, Lubansu A Abstract BACKGROUND: When Belgium's coronavirus disease 2019 (COVID-19) outbreak began in March 2020, our neurosurgical department followed the protocol of most surgical departments in the world and postponed elective surgery. However,...
Sat Sep 12, 2020 08:43
Related Articles CASPR2 autoimmunity in children expanding to mild encephalopathy with hypertension. Neurology. 2020 06 02;94(22):e2290-e2301 Authors: Syrbe S, Stettner GM, Bally J, Borggraefe I, Bien CI, Ferfoglia RI, Huppke P, Kern J, Polster T, Probst-Müller E, Schmid S, Steinfeld R, Strozzi S, Weichselbaum A, Weitz M, Ziegler A, Wandinger KP, Leypoldt F, Bien CG Abstract OBJECTIVE: To delineate autoimmune disease in association with contactin-associated...
Sat Sep 12, 2020 08:43
Related Articles Quality improvement in neurology: Neurology Outcomes Quality Measurement Set. Neurology. 2020 06 02;94(22):982-990 Authors: Sico JJ, Sarwal A, Benish SM, Busis NA, Cohen BH, Das RR, Finsilver S, Halperin JJ, Kelly AG, Meunier L, Phipps MS, Thirumala PD, Villanueva R, von Gaudecker J, Bennett A, Shenoy AM PMID: 32398356 [PubMed - indexed for MEDLINE]
Sat Sep 12, 2020 08:43
Related Articles Continuous Dynamic Mapping to Identify the Corticospinal Tract in Motor Eloquent Brain Tumors: An Update. J Neurol Surg A Cent Eur Neurosurg. 2020 Mar;81(2):105-110 Authors: Seidel K, Schucht P, Beck J, Raabe A Abstract OBJECTIVE: We recently developed a new subcortical mapping technique based on the concept of stimulating the tissue at the site of and synchronously with resection. Our hypothesis was that instead of performing...
Sat Sep 12, 2020 08:43
Related Articles Localization of Expressive Language Cortex in a 2-Year-Old Child Using High-Gamma Electrocorticography. J Child Neurol. 2019 11;34(13):837-841 Authors: Babajani-Feremi A, Fulton SP, Holder CM, Choudhri AF, Boop FA, Wheless JW Abstract Cortical stimulation mapping is the gold standard for presurgical language mapping; however, it cannot be reliably performed in very young patients. Language mapping using noninvasive modalities...
Sat Sep 12, 2020 08:43
Moderate alcohol consumption is associated with impaired insulin secretion and fasting glucose in non-obese non-diabetic men. J Diabetes Investig. 2020 Sep 10;: Authors: Miyagi S, Takamura T, Nguyen TTT, Tsujiguchi H, Hara A, Nakamura H, Suzuki K, Tajima A, Kannon T, Toyama T, Kambayashi Y, Nakamura H Abstract AIMS: A low insulin secretion capacity has been implicated in the high prevalence of non-obese diabetes in East Asians. Since alcohol...
Sat Sep 12, 2020 08:38
The evolving metabolic landscape of chromatin biology and epigenetics. Nat Rev Genet. 2020 Sep 09;: Authors: Dai Z, Ramesh V, Locasale JW Abstract Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These inputs - which include both nutrient availability as a result of diet and growth factor signalling - are implicated in linking the environment to the maintenance of cellular homeostasis and cell identity....
Sat Sep 12, 2020 08:38
Corni Fructus as a Natural Resource Can Treat Type 2 Diabetes by Regulating Gut Microbiota. Am J Chin Med. 2020 Sep 09;:1-23 Authors: Niu D, An S, Chen X, Bi H, Zhang Q, Wang T, Han B, Zhang H, Kang J Abstract Accumulating evidence suggests that gut microbiota plays a crucial role in the development of metabolic diseases, especially type 2 diabetes mellitus (T2DM). The nutrient-rich resource Cornus Fructus (CF) showed curative effects on diabetes...
Sat Sep 12, 2020 08:38
Related Articles In silico co-factor balance estimation using constraint-based modelling informs metabolic engineering in Escherichia coli. PLoS Comput Biol. 2020 08;16(8):e1008125 Authors: de Arroyo Garcia L, Jones PR Abstract In the growing field of metabolic engineering, where cells are treated as 'factories' that synthesize industrial compounds, it is essential to consider the ability of the cells' native metabolism to accommodate the...
Sat Sep 12, 2020 08:38
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:The treatment options for intractable metastatic colorectal cancer include regorafenib, trifluridine/tipiracil, and fruquintinib. In this study, we aimed to conduct a network meta-analysis for comparing the efficacy of these agents.Methods:We searched the PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and ClinicalTrials databases for relevant literature, up to February 2020. The data...
Fri Sep 11, 2020 12:47
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Objective:Previous studies have shown that abnormal expression of microRNA-184 leads to a variety of cancers, including pancreatic ductal adenocarcinoma, suggesting microRNA-184 as a new treatment target for pancreatic ductal adenocarcinoma. However, the molecular mechanism of microRNA-184 in pancreatic ductal adenocarcinoma remains unclear. It is important to investigate the effect and role of microRNA-184 in...
Fri Sep 11, 2020 12:46
On-Site Monitoring of Postoperative Bile Leakage Using Bilirubin-Inducible Fluorescent Protein. World J Surg. 2020 Sep 09;: Authors: Kono Y, Ishizawa T, Kokudo N, Kuriki Y, Iwatate RJ, Kamiya M, Urano Y, Kumagai A, Kurokawa H, Miyawaki A, Hasegawa K Abstract BACKGROUND: Bile leakage is the most common postoperative complication associated with hepatobiliary and pancreatic surgery. Until now, however, a rapid, accurate diagnostic method for...
Sat Sep 12, 2020 08:33
The Prognostic Relevance of the Number and Location of Positive Lymph Nodes for Ampulla of Vater Carcinoma. World J Surg. 2020 Sep 09;: Authors: Matsui S, Yamamoto Y, Sugiura T, Okamura Y, Ito T, Ashida R, Ohgi K, Imamura T, Uesaka K Abstract BACKGROUND: Lymph node metastasis (LNM) has been regarded as one of the prognostic factors in patients with ampulla of Vater carcinoma (AC). However, the consensus about an optimal cutoff value of the...
Sat Sep 12, 2020 08:33
Related Articles Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice. Sci Rep. 2019 02 22;9(1):2573 Authors: Reijntjes DOJ, Lee JH, Park S, Schubert NMA, van Tuinen M, Vijayakumar S, Jones TA, Jones SM, Gratton MA, Xia XM, Yamoah EN, Pyott SJ Abstract Potassium (K+) channels shape the response properties of neurons. Although enormous progress has been made to characterize...
Sat Sep 12, 2020 08:32
The phenomenon of a massive vertebral deformity was recorded in the radiating Labeobarbus assemblage from the middle reaches of the Genale River (south-eastern Ethiopia, East Africa). Within this sympatric assemblage, five trophic morphs - generalized, lipped, piscivorous and two scraping feeders - were reported between 1993 and 2019. In 2009, a new morph with prevalence of ~10% was discovered. The new morph, termed short, had an abnormally shortened vertebral column and a significantly heightened...
Fri Sep 11, 2020 03:00
X chromosome inactivation (XCI) mediated by differential DNA methylation between sexes is well characterized in eutherian mammals. Although XCI is shared between eutherians and marsupials, the role of DNA methylation in marsupial XCI remains contested. Here we examine genome-wide signatures of DNA methylation from methylation maps across fives tissues from a male and female koala (Phascolarctos cinereus) and present the first whole genome, multi-tissue marsupial "methylome atlas." Using these novel...
Fri Sep 11, 2020 03:00
The effectiveness of a preoperative multi-component non-pharmacologic preparation on post-tonsillectomy pain: A randomized controlled clinical trial. Int J Pediatr Otorhinolaryngol. 2020 Sep 01;138:110359 Authors: Faramarzi M, Roosta S, Faramarzi A, Salehi A, Matani N Abstract INTRODUCTION: Tonsillectomy is a painful operation and some studies have suggested that preoperative non-pharmacologic preparations may decrease postoperative pain. In...
Sat Sep 12, 2020 08:20
Biofilm distribution on tympanostomy tubes: An ex vivo descriptive study. Int J Pediatr Otorhinolaryngol. 2020 Sep 03;138:110350 Authors: Habashi N, Marom T, Steinberg D, Zacks B, Tamir SO Abstract BACKGROUND: Tympanostomy tube (TT) insertion is a common procedure in children with otitis media with effusion. Post-TT otorrhea (PTTO) is a frequent post-operative complication. Biofilms are involved in chronic PTTO cases. OBJECTIVE: To...
Sat Sep 12, 2020 08:20
Exploring the utility of fibreoptic endoscopic evaluation of swallowing in young children- A comparison with videofluoroscopy. Int J Pediatr Otorhinolaryngol. 2020 Aug 29;138:110339 Authors: Pavithran J, Puthiyottil IV, Kumar M, Nikitha AV, Vidyadharan S, Bhaskaran R, Chandrababu Jaya A, Thankappan K, Subramania I, Sundaram KR Abstract OBJECTIVES/HYPOTHESIS: In adults, fibreoptic endoscopic evaluation of swallowing (FEES) has established its...
Sat Sep 12, 2020 08:20
Routine vocal cord mobility assessment post cardiac surgery via median sternotomy approach. Int J Pediatr Otorhinolaryngol. 2020 Aug 30;138:110331 Authors: Lambert A, Winlaw DS, Deacon V, Waters KA, Pettigrew J, Fleming G, Orr Y, Wong EH, Cheng AT Abstract OBJECTIVES: Surgery of the aortic arch carries a risk of injury to the vagus and recurrent laryngeal nerves, particularly in a young child, as these structures lie in close proximity to aortic...
Sat Sep 12, 2020 08:20
Medical and surgical characteristics of fusobacterium necrophorum mastoiditis in children. Int J Pediatr Otorhinolaryngol. 2020 Aug 18;138:110324 Authors: Ulanovski D, Shavit SS, Scheuerman O, Sokolov M, Hilly O, Raveh E Abstract OBJECTIVES: To evaluate and compare characteristics of Fusobacterium necrophorum mastoiditis (FnM) to characteristics of acute mastoiditis (AM) caused by other bacteria in tertiary children hospital Methods : Children...
Sat Sep 12, 2020 08:20
30 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2020/09/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Sep 12, 2020 08:14
Related Articles Development and Validation of a Novel Surgical Simulation for Parotidectomy and Facial Nerve Dissection. Otolaryngol Head Neck Surg. 2020 08;163(2):344-347 Authors: Gabrysz-Forget F, Rubin S, Nepomnayshy D, Dolan R, Yarlagadda B Abstract We present the development and validation of a low-cost novel model for training of parotid surgery. The model consists of a 3-dimensionally printed skeleton, silicone-based soft tissue, and...
Sat Sep 12, 2020 08:06
Unpredicted Bilateral Device Breakage during Active Phase of Mandibular Distraction: A Case Report and Literature Review. J Stomatol Oral Maxillofac Surg. 2020 Sep 07;: Authors: Dasukil S, Verma S, Boyina KK, Jena AK Abstract Distraction osteogenesis is a popular treatment modality to lengthen the mandible. It is commonly performed in wide varieties of craniofacial syndromes, temporomandibular joint (TMJ) ankylosis, and obstructive sleep apnea...
Sat Sep 12, 2020 07:57
Chronic intermittent hypoxia alters the dendritic mitochondrial structure and activity in the pre-Bötzinger complex of rats. FASEB J. 2020 Sep 10;: Authors: Kang JJ, Fung ML, Zhang K, Lam CS, Wu SX, Huang XF, Yang SJ, Wong-Riley MTT, Liu YY Abstract Mitochondrial bioenergetics is dynamically coupled with neuronal activities, which are altered by hypoxia-induced respiratory neuroplasticity. Here we report structural features of postsynaptic...
Sat Sep 12, 2020 07:57
CPAP combined with oral appliance therapy reduces CPAP requirements and pharyngeal pressure swings in obstructive sleep apnea. J Appl Physiol (1985). 2020 Sep 10;: Authors: Tong BK, Tran C, Ricciardiello A, Donegan M, Chiang AKI, Szollosi I, Amatoury J, Carberry JC, Eckert DJ Abstract STUDY OBJECTIVES: Oral appliance (OA) therapy is the leading alternative to continuous positive airway pressure (CPAP) for obstructive sleep apnea (OSA). It is...
Sat Sep 12, 2020 07:57
Obstructive sleep apnea in adults with Down syndrome. Am J Med Genet A. 2020 Sep 10;: Authors: Landete P, Soriano JB, Aldave B, Zamora E, Acosta C, Erro M, López Riolobos C, Ramos MI, Moldenhauer F, Ancochea J Abstract Patients with Down syndrome (DS) often have a high occurrence of obstructive sleep apnea-hypopnea (OSA) syndrome. We studied a large cohort of adults with DS attended due to clinical suspicion of OSA. A standardized questionnaire...
Sat Sep 12, 2020 07:57
Obstructive Sleep Apnea and Risk for Incident Vertebral and Hip Fracture in Women. J Bone Miner Res. 2020 Sep 09;: Authors: Huang T, Tworoger SS, Redline S, Curhan GC, Paik JM Abstract Recent studies suggest a positive association between obstructive sleep apnea (OSA), a disorder associated with intermittent hypoxia and sleep fragmentation, and derangements in bone metabolism. However, no prospective study to date has investigated the association...
Sat Sep 12, 2020 07:57
Saethre-Chotzen syndrome: long-term outcome of a syndrome-specific management protocol. Dev Med Child Neurol. 2020 Sep 09;: Authors: Den Ottelander BK, Van Veelen MC, De Goederen R, Van De Beeten SD, Dremmen MH, Loudon SE, Versnel SL, Van Den Ouweland AM, Van Dooren MF, Joosten KF, Mathijssen IM Abstract AIM: To assess the long-term outcomes of our management protocol for Saethre-Chotzen syndrome, which includes one-stage fronto-orbital advancement....
Sat Sep 12, 2020 07:57
Factors influencing the choice between laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass.
Factors influencing the choice between laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass. Surg Endosc. 2020 Sep 09;: Authors: Nasser H, Ivanics T, Carlin AM Abstract BACKGROUND: While laparoscopic sleeve gastrectomy (LSG) continues to be the most commonly performed bariatric operation, several variables influence surgeons' practice patterns and patients' decision-making in the type of bariatric procedure to perform. The aim of this...
Sat Sep 12, 2020 07:57
Related Articles Clinical features of children with Haddad syndrome: A single-center experience. J Pediatr Surg. 2020 Mar;55(3):387-392 Authors: Woo HY, Oh C, Han JW, Kim HY, Jung SE Abstract BACKGROUND/PURPOSE: Haddad syndrome (HS) is a very rare disease considered a form of neurocristopathy. It is characterized by a combination of congenital central hypoventilation syndrome (CCHS) and Hirschsprung's disease (HD). We report the clinical features...
Sat Sep 12, 2020 07:57
Patient-Reported Factors Associated with the Onset of Hyperfunctional Voice Disorders. Ann Otol Rhinol Laryngol. 2020 Sep 10;:3489420956379 Authors: Kridgen S, Hillman RE, Stadelman-Cohen T, Zeitels S, Burns JA, Hron T, Krusemark C, Muise J, Van Stan JH Abstract OBJECTIVES: Prevention, diagnosis, and treatment of hyperfunctional voice disorders would be improved by better understanding their etiological contributing factors. Therefore, this...
Sat Sep 12, 2020 07:50
An intact gut microbiome protects genetically predisposed mice against leukemia. Blood. 2020 Sep 10;: Authors: Vicente Dueñas C, Janssen S, Oldenburg M, Auer F, González Herrero I, Casado-García A, Isidro-Hernández M, Raboso-Gallego J, Westhoff P, Pandyra AA, Hein D, Gössling KL, Alonso-López D, De Las Rivas J, Bhatia S, Garcia-Criado FJ, García Cenador MB, Weber APM, Köhrer K, Hauer J, Fischer U, Sanchez-Garcia I, Borkhardt A Abstract The...
Sat Sep 12, 2020 07:47
Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective. Regul Toxicol Pharmacol. 2020 Sep 08;117:104746 Authors: Reynolds VL, Butler P, Abernathy MM, Aschenbrenner L, Best DD, Blank J, Crosby M, Custer L, Escobar PA, Kolaja K, Moggs J, Shuey D, Snyder C, Van Vleet T, Zhou J, Hart TK Abstract Pharmaceutic products designed to perturb the function of epigenetic modulators have been approved by regulatory...
Sat Sep 12, 2020 07:47
Cardio-oncology care in the era of the coronavirus disease 2019 (COVID-19) pandemic: An International Cardio-Oncology Society (ICOS) statement. CA Cancer J Clin. 2020 Sep 10;: Authors: Lenihan D, Carver J, Porter C, Liu JE, Dent S, Thavendiranathan P, Mitchell JD, Nohria A, Fradley MG, Pusic I, Stockerl-Goldstein K, Blaes A, Lyon AR, Ganatra S, López-Fernández T, O'Quinn R, Minotti G, Szmit S, Cardinale D, Alvarez-Cardona J, Curigliano G, Neilan TG, Herrmann...
Sat Sep 12, 2020 07:47
Results of an early safety analysis of a study of the combination of pembrolizumab and pelvic chemoradiation in locally advanced cervical cancer. Cancer. 2020 Sep 10;: Authors: Duska LR, Scalici JM, Temkin SM, Schwarz JK, Crane EK, Moxley KM, Hamilton CA, Wethington SL, Petroni GR, Varhegyi NE, Clift SH, Bullock TNJ, Showalter TN Abstract BACKGROUND: Immune checkpoint inhibitors are being considered for locally advanced cervical cancer (LACC)...
Sat Sep 12, 2020 07:47
Augmented reality with HoloLens in parotid surgery: how to assess and to improve accuracy. Eur Arch Otorhinolaryngol. 2020 Sep 10;: Authors: Scherl C, Stratemeier J, Karle C, Rotter N, Hesser J, Huber L, Dias A, Hoffmann O, Riffel P, Schoenberg SO, Schell A, Lammert A, Affolter A, Männle D Abstract PURPOSE: Augmented reality improves planning and execution of surgical procedures. The aim of this study was to evaluate the feasibility of a 3D...
Sat Sep 12, 2020 07:47
Evaluation of Adjuvant Chemotherapy in Patients With Resected Pancreatic Cancer After Neoadjuvant FOLFIRINOX Treatment. JAMA Oncol. 2020 Sep 10;: Authors: van Roessel S, van Veldhuisen E, Klompmaker S, Janssen QP, Abu Hilal M, Alseidi A, Balduzzi A, Balzano G, Bassi C, Berrevoet F, Bonds M, Busch OR, Butturini G, Del Chiaro M, Conlon KC, Falconi M, Frigerio I, Fusai GK, Gagnière J, Griffin O, Hackert T, Halimi A, Klaiber U, Labori KJ, Malleo G, Marino MV, Mortensen...
Sat Sep 12, 2020 07:47
Challenges in the quantification approach to a radiation relevant adverse outcome pathway for lung cancer. Int J Radiat Biol. 2020 Sep 10;:1-61 Authors: Stainforth R, Schuemann J, McNamara AL, Wilkins R, Chauhan V Abstract Purpose: Adverse outcome pathways (AOPs) provide a modular framework for describing sequences of biological key events (KEs) and key event relationships (KERs) across levels of biological organization. Empirical evidence...
Sat Sep 12, 2020 07:47
Prostate re-irradiation: current concerns and future perspectives. Expert Rev Anticancer Ther. 2020 Sep 10;: Authors: Cuccia F, Mazzola R, Nicosia L, Giaj-Levra N, Figlia V, Ricchetti F, Rigo M, Vitale C, Corradini S, Alongi F Abstract INTRODUCTION: To date, the optimal management of locally relapsed prostate cancer patients after an initial course of radiotherapy, remains a matter of debate. In recent years, local approaches have been proposed...
Sat Sep 12, 2020 07:47
Thiol-disulfide status of patients with cervical cancer. J Obstet Gynaecol Res. 2020 Sep 09;: Authors: Sezgin B, Kinci MF, Pirinççi F, Camuzcuoğlu A, Erel Ö, Neşelioğlu S, Camuzcuoğlu H Abstract AIM: The evaluation of dynamic thiol-disulfide homeostasis among patients with the cancer of the uterine cervix. METHODS: The study was conducted in 62 cervical cancer patients and 61 healthy women who had been followed up in an obstetrics...
Sat Sep 12, 2020 07:47
Scoping review: hotspots for COVID-19 urological research: what is being published and from where? World J Urol. 2020 Sep 09;: Authors: Qu LG, Perera M, Lawrentschuk N, Umbas R, Klotz L Abstract PURPOSE: Contemporary, original research should be utilised to inform guidelines in urology relating to the COVID-19 pandemic. This comprehensive review aimed to: identify all up-to-date original publications relating to urology and COVID-19, characterise...
Sat Sep 12, 2020 07:47
Neoadjuvant therapy strategies for advanced gastric cancer: Current innovations and future challenges. Chronic Dis Transl Med. 2020 Sep;6(3):147-157 Authors: Zhu Z, Gong YB, Xu HM Abstract Gastric cancer, which has a high incidence and poor prognosis, remains a therapeutic challenge. Recently, neoadjuvant therapy has attracted increasing attention due to high recurrence rate and low survival rate after resection in most patients with advanced...
Sat Sep 12, 2020 07:47
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