Antibiotics, Vol. 9, Pages 599: Can the One Health Approach Save Us from the Emergence and Reemergence of Infectious Pathogens in the Era of Climate Change: Implications for Antimicrobial Resistance? Antibiotics doi: 10.3390/antibiotics9090599 Authors: Smitha Gudipati Marcus Zervos Erica Herc Climate change has become a controversial topic in today’s media despite decades of warnings from climate scientists and has influenced human health significantly with the increasing prevalence...
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Antibiotics, Vol. 9, Pages 598: Antimicrobial Consumption and Resistance in a Tertiary Care Hospital in Jordan: Results of an Internet-Based Global Point Prevalence Survey Antibiotics doi: 10.3390/antibiotics9090598 Authors: Khawla Abu Hammour Esraa AL-Heyari Aya Allan Ann Versporten Herman Goossens Ghayda’ Abu Hammour Qusai Manaseer Background: The Global Point Prevalence Survey (Global-PPS) provides a standardised method to conduct surveillance of antimicrobial prescribing...
Sun Sep 13, 2020 03:00
Antibiotics, Vol. 9, Pages 597: Evidence of the Practice of Self-Medication with Antibiotics among the Lay Public in Low- and Middle-Income Countries: A Scoping Review Antibiotics doi: 10.3390/antibiotics9090597 Authors: Adeel Aslam Márió Gajdács Che Suraya Zin Norny Syafinaz Ab Rahman Syed Imran Ahmed Muhammad Zeeshan Zafar Shazia Jamshed The current scoping review is an attempt to explore the key reasons, determinants, patterns and prevalence related to self-medication...
Sat Sep 12, 2020 03:00
Antibiotics, Vol. 9, Pages 596: Identification of the PA1113 Gene Product as an ABC Transporter Involved in the Uptake of Carbenicillin in Pseudomonas aeruginosa PAO1 Antibiotics doi: 10.3390/antibiotics9090596 Authors: Christian Hulen Pierre-jean Racine Sylvie Chevalier Marc Feuilloley Nour-Eddine LOMRI The resistance of Pseudomonas aeruginosa to antibiotics is multi factorial and complex. Whereas efflux pumps such as MexAB-OprM have been thought to predominate, here we...
Fri Sep 11, 2020 03:00
Antibiotics, Vol. 9, Pages 595: Indoline-6-Sulfonamide Inhibitors of the Bacterial Enzyme DapE Antibiotics doi: 10.3390/antibiotics9090595 Authors: Reidl Heath Darwish Torrez Moore Gild Nocek Starus Holz Becker Inhibitors of the bacterial enzyme dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE; EC 3.5.1.18) hold promise as antibiotics with a new mechanism of action. Herein we describe the discovery of a new series of indoline sulfonamide...
Fri Sep 11, 2020 03:00
Antioxidants, Vol. 9, Pages 859: Macrocycles and Supramolecules as Antioxidants: Excellent Scaffolds for Development of Potential Therapeutic Agents Antioxidants doi: 10.3390/antiox9090859 Authors: Jung-Seop Lee In-ho Song Pramod B. Shinde Satish Balasaheb Nimse Oxidative stress due to the high levels of reactive oxygen species (ROS) that damage biomolecules (lipids, proteins, DNA) results in acute inflammation. However, without proper intervention, acute inflammation progresses...
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Antioxidants, Vol. 9, Pages 857: Overview of Salvia miltiorrhiza as a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of Action Antioxidants doi: 10.3390/antiox9090857 Authors: Inyong Jung Hyerin Kim Seongcheol Moon Hyuk Lee Bonglee Kim Salvia miltiorrhiza Bunge (S. miltiorrhiza) is a medicinal herb that has been used for the treatment for various diseases such as cardiovascular and cerebrovascular diseases in East Asia including Korea....
Sun Sep 13, 2020 03:00
Antioxidants, Vol. 9, Pages 858: SIRT1/SIRT3 Modulates Redox Homeostasis during Ischemia/Reperfusion in the Aging Heart Antioxidants doi: 10.3390/antiox9090858 Authors: Jingwen Zhang Di Ren Julia Fedorova Zhibin He Ji Li Ischemia/reperfusion (I/R) injury is the central cause of global death in cardiovascular diseases, which is characterized by disorders such as angina, stroke, and peripheral vascular disease, finally causing severe debilitating diseases and death. The increased...
Sun Sep 13, 2020 03:00
Antioxidants, Vol. 9, Pages 856: Maternal N-Acetylcysteine Therapy Prevents Hypertension in Spontaneously Hypertensive Rat Offspring: Implications of Hydrogen Sulfide-Generating Pathway and Gut Microbiota Antioxidants doi: 10.3390/antiox9090856 Authors: Chien-Ning Hsu Chih-Yao Hou Guo-Ping Chang-Chien Sufan Lin You-Lin Tain Hypertension can come from early life. N-acetylcysteine (NAC), a hydrogen sulfide (H2S) precursor as well as an antioxidant, has antihypertensive effect....
Sun Sep 13, 2020 03:00
Antioxidants, Vol. 9, Pages 855: Hercynine, Ergothioneine and Redox State in Stallion’s Seminal Plasma Antioxidants doi: 10.3390/antiox9090855 Authors: Salvatore Sotgia Andrea Taras Angelo Zinellu Raffaele Cherchi Arduino A Mangoni Ciriaco Carru Luisa Bogliolo The dependence of a stallion’s spermatozoa on oxidative phosphorylation for energy requirements results in an unconventional relationship between reactive oxygen species (ROS) production and fertility....
Sun Sep 13, 2020 03:00
Antioxidants, Vol. 9, Pages 854: Epigallocatechin-3-Gallate and PEDF 335 Peptide, 67LR Activators, Attenuate Vasogenic Edema, and Astroglial Degeneration Following Status Epilepticus Antioxidants doi: 10.3390/antiox9090854 Authors: Kim Park Jeong Kang Non-integrin 67-kDa laminin receptor (67LR) is involved in cell adherence to the basement membrane, and it regulates the interactions between laminin and other receptors. The dysfunction of 67LR leads to serum extravasation...
Fri Sep 11, 2020 03:00
Antioxidants, Vol. 9, Pages 853: Restraint Stress Alters Expression of Glucocorticoid Bioavailability Mediators, Suppresses Nrf2, and Promotes Oxidative Stress in Liver Tissue Antioxidants doi: 10.3390/antiox9090853 Authors: Hsiao-Jou Cortina Chen Tsz Yip Johnny K. Lee Juliani Juliani Conrad Sernia Andrew F. Hill Nickolas A. Lavidis Jereme G. Spiers Hepatic glutathione synthesis and antioxidant protection are critically important for efficient detoxification processes...
Fri Sep 11, 2020 03:00
Atmosphere, Vol. 11, Pages 982: Better Agronomic Management Increases Climate Resilience of Maize to Drought in Tanzania Atmosphere doi: 10.3390/atmos11090982 Authors: Wei Xiong Elena Tarnavsky Improved access to better seeds and other inputs, as well as to market and financing, provides greater harvest security for smallholder farmers in Africa, boosting their incomes and increasing food security. Since 2015, a variety of agronomic measures have been introduced and adopted by smallholder...
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Atmosphere, Vol. 11, Pages 981: What Can We Learn from Comparing Glacio-Hydrological Models? Atmosphere doi: 10.3390/atmos11090981 Authors: Elena Stoll Florian Hanzer Felix Oesterle Johanna Nemec Johannes Schöber Matthias Huttenlau Kristian Förster Glacio-hydrological models combine both glacier and catchment hydrology modeling and are used to assess the hydrological response of high-mountain glacierized catchments to climate change. To capture the uncertainties from...
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Atmosphere, Vol. 11, Pages 980: Unmanned Aerial Vehicle Observations of the Vertical Distribution of Particulate Matter in the Surface Layer of the Taklimakan Desert in China Atmosphere doi: 10.3390/atmos11090980 Authors: Lili Jin Qing He Hong Jiang Junan Xiao Quanwei Zhao Sasa Zhou Zhenjie Li Jiawei Zhao Field observations made with unmanned aerial vehicles of the particulate matter (PM) concentration from the ground to a height of 500 m were conducted at Xiaotang...
Sun Sep 13, 2020 03:00
Atmosphere, Vol. 11, Pages 979: Natural Seepage of Methane and Light Alkanes at Three Locations in Southern California Atmosphere doi: 10.3390/atmos11090979 Authors: Brynne M. Weed Gisselle D. Brambila Lambert A. Doezema Methane and light (C2–C5) alkane fluxes were measured from three geologic seepage sites in Southern California during May and June of 2019. Samples were collected from visible macroseeps in Carpinteria, McKittrick, and Ojai using an aluminum flux chamber...
Sat Sep 12, 2020 03:00
Atmosphere, Vol. 11, Pages 978: Temperature Response from the Change of Surface Heat Flux and Vertical Diffusivity by Urbanization Atmosphere doi: 10.3390/atmos11090978 Authors: Shuzhan Ren Craig A. Stroud A 1-D diffusion model of temperature is employed to understand important features of temperature response to the changes of surface heat flux (SHF) and vertical diffusivity shown in 3-D model simulations. Analytical results show that the temperature response to the SHF change is...
Sat Sep 12, 2020 03:00
Atmosphere, Vol. 11, Pages 977: Volcanic Ash Resuspension in Patagonia: Numerical Simulations and Observations Atmosphere doi: 10.3390/atmos11090977 Authors: Leonardo Mingari Arnau Folch Lucia Dominguez Costanza Bonadonna Resuspension of pyroclastic deposits occurs under specific atmospheric and environmental conditions and typically prolongs and exacerbates the impact associated with the primary emplacement of tephra fallout and pyroclastic density current deposits. An accurate...
Sat Sep 12, 2020 03:00
Atmosphere, Vol. 11, Pages 976: Long-Term Analysis of Atmospheric Energetics Components over the Mediterranean, Middle East and North Africa Atmosphere doi: 10.3390/atmos11090976 Authors: Silas Michaelides In this research, one aspect of the climate that is not commonly referred to, namely, the long-term changes in the components of the atmospheric energy, is investigated. In this respect, the changes in four energy forms are considered, namely, Kinetic Energy (KE), Thermal Energy (TE),...
Fri Sep 11, 2020 03:00
Atmosphere, Vol. 11, Pages 974: The Impact of Passive Green Technologies on the Microclimate of Historic Urban Structures: The Case Study of Lodz Atmosphere doi: 10.3390/atmos11090974 Authors: Anna Dominika Bochenek Katarzyna Klemm Rapid population growth necessitates modifications of urban form, especially in city centers. Consequently, the correlation of the outdoor environment with the occupant’s behavior has profoundly changed. In this study, the authors describe a method,...
Fri Sep 11, 2020 03:00
Atmosphere, Vol. 11, Pages 975: Precipitation Microphysical Characteristics of Typhoon Mangkhut in Southern China Using 2D Video Disdrometers Atmosphere doi: 10.3390/atmos11090975 Authors: Lu Feng Sheng Hu Xiantong Liu Hui Xiao Xiao Pan Feng Xia Guanhua Ou Chu Zhang The microphysical characteristics of tropical cyclones vary in different rain regions, which affects not only the dynamic and thermodynamic mechanisms of the typhoon system but also the development of...
Fri Sep 11, 2020 03:00
Atmosphere, Vol. 11, Pages 971: Integrated Flood Forecasting and Warning System against Flash Rainfall in the Small-Scaled Urban Stream Atmosphere doi: 10.3390/atmos11090971 Authors: Jung Hwan Lee Gi Moon Yuk Hyeon Tae Moon Young-Il Moon The flood forecasting and warning system enable an advanced warning of flash floods and inundation depths for disseminating alarms in urban areas. Therefore, in this study, we developed an integrated flood forecasting and warning system combined...
Fri Sep 11, 2020 03:00
Atmosphere, Vol. 11, Pages 973: Towards a Better Design of Convection-Allowing Ensembles for Precipitation Forecasts over Ensenada, Baja California, Mexico Atmosphere doi: 10.3390/atmos11090973 Authors: Yandy G. Mayor Markus Gross Vanesa Magar Convective ensembles promise to increase forecast accuracy while at the same time providing information on the probability of the forecast. A vast number of different methods of ensemble creation have been developed over time. Here, initial...
Fri Sep 11, 2020 03:00
Atmosphere, Vol. 11, Pages 972: Regional Delimitation of PM2.5 Pollution Using Spatial Cluster for Monitoring Sites: A Case Study of Xianyang, China Atmosphere doi: 10.3390/atmos11090972 Authors: Bo Zhang Fang Zhou Guojun Song Fine particulate matter (PM2.5) pollution has been a major concerning issue in China, and many cities have developed emergency plans for heavy air pollution. The aim of this study is to delimitate PM2.5 pollution regions of Xianyang, which is very important...
Fri Sep 11, 2020 03:00
Bioengineering, Vol. 7, Pages 110: Elastin-Collagen Based Hydrogels as Model Scaffolds to Induce Three-Dimensional Adipocyte Culture from Adipose Derived Stem Cells Bioengineering doi: 10.3390/bioengineering7030110 Authors: Kristen Newman Kendra Clark Bhuvaneswari Gurumurthy Pallabi Pal Amol V. Janorkar This study aimed to probe the effect of formulation of scaffolds prepared using collagen and elastin-like polypeptide (ELP) and their resulting physico-chemical and mechanical...
Sat Sep 12, 2020 03:00
Bioengineering, Vol. 7, Pages 109: SlicerArduino: A Bridge between Medical Imaging Platform and Microcontroller Bioengineering doi: 10.3390/bioengineering7030109 Authors: Paolo Zaffino Alessio Merola Domenico Leuzzi Virgilio Sabatino Carlo Cosentino Maria Francesca Spadea Interaction between medical image platform and external environment is a desirable feature in several clinical, research, and educational scenarios. In this work, the integration between 3D Slicer package...
Fri Sep 11, 2020 03:00
Biology, Vol. 9, Pages 287: Metabolites Produced by Kaistia sp. 32K Promote Biofilm Formation in Coculture with Methylobacterium sp. ME121 Biology doi: 10.3390/biology9090287 Authors: Yoshiaki Usui Tetsu Shimizu Akira Nakamura Masahiro Ito Previously, we reported that the coculture of motile Methylobacterium sp. ME121 and non-motile Kaistia sp. 32K, isolated from the same soil sample, displayed accelerated motility of strain ME121 due to an extracellular polysaccharide (EPS)...
Sun Sep 13, 2020 03:00
Biology, Vol. 9, Pages 285: A Glance of p53 Functions in Brain Development, Neural Stem Cells, and Brain Cancer Biology doi: 10.3390/biology9090285 Authors: Yuqing Xiong Yun Zhang Shunbin Xiong Abie E. Williams-Villalobo p53 is one of the most intensively studied tumor suppressors. It transcriptionally regulates a broad range of genes to modulate a series of cellular events, including DNA damage repair, cell cycle arrest, senescence, apoptosis, ferroptosis, autophagy, and metabolic...
Fri Sep 11, 2020 03:00
Biology, Vol. 9, Pages 286: Antifungal Activity and Phytochemical Screening of Vernonia amygdalina Extract against Botrytis cinerea Causing Gray Mold Disease on Tomato Fruits Biology doi: 10.3390/biology9090286 Authors: Siti Fairuz Yusoff Farah Farhanah Haron Mahmud Tengku Muda Mohamed Norhayu Asib Siti Zaharah Sakimin Faizah Abu Kassim Siti Izera Ismail Gray mold disease caused by Botrytis cinerea is a damaging postharvest disease in tomato plants, and it is known...
Fri Sep 11, 2020 03:00
Biology, Vol. 9, Pages 283: Cnidarian Immunity and the Repertoire of Defense Mechanisms in Anthozoans Biology doi: 10.3390/biology9090283 Authors: Maria Giovanna Parisi Daniela Parrinello Loredana Stabili Matteo Cammarata Anthozoa is the most specious class of the phylum Cnidaria that is phylogenetically basal within the Metazoa. It is an interesting group for studying the evolution of mutualisms and immunity, for despite their morphological simplicity, Anthozoans are unexpectedly...
Fri Sep 11, 2020 03:00
Biology, Vol. 9, Pages 284: Short-Term Effects of Early Menopause on Adiposity, Fatty Acids Profile and Insulin Sensitivity of a Swine Model of Female Obesity Biology doi: 10.3390/biology9090284 Authors: Ana Heras-Molina José Luis Pesantez-Pacheco Marta Vazquez-Gomez Consolacion Garcia-Contreras Susana Astiz Beatriz Isabel Antonio Gonzalez-Bulnes Menopause strongly increases incidence and consequences of obesity and non-communicable diseases in women, with recent research...
Fri Sep 11, 2020 03:00
Biomedicines, Vol. 8, Pages 349: Lung Microbiome Differentially Impacts Survival of Patients with Non-Small Cell Lung Cancer Depending on Tumor Stroma Phenotype Biomedicines doi: 10.3390/biomedicines8090349 Authors: Olga Kovaleva Polina Podlesnaya Madina Rashidova Daria Samoilova Anatoly Petrenko Irina Zborovskaya Valeria Mochalnikova Vladimir Kataev Yuri Khlopko Andrey Plotnikov Alexei Gratchev The link between a lung tumor and the lung microbiome is a...
Sun Sep 13, 2020 03:00
Biomedicines, Vol. 8, Pages 347: Emerging Nanopharmaceuticals and Nanonutraceuticals in Cancer Management Biomedicines doi: 10.3390/biomedicines8090347 Authors: Lavinia Salama Elizabeth R. Pastor Tyler Stone Shaker A. Mousa Nanotechnology is the science of nanoscale, which is the scale of nanometers or one billionth of a meter. Nanotechnology encompasses a broad range of technologies, materials, and manufacturing processes that are used to design and/or enhance many products,...
Sat Sep 12, 2020 03:00
Biomedicines, Vol. 8, Pages 348: Utility of Reactive Species Generation in Plasma Medicine for Neuronal Development Biomedicines doi: 10.3390/biomedicines8090348 Authors: Sarmistha Mitra Neha Kaushik Il Soo Moon Eun Ha Choi Nagendra Kumar Kaushik Reactive oxygen species (ROS) are critical signaling molecules for neuronal physiology that stimulate growth and development and play vital roles in several pathways when in a balanced state, but they cause neurodegeneration when...
Sat Sep 12, 2020 03:00
Biomedicines, Vol. 8, Pages 346: Regulation of JAM2 Expression in the Lungs of Streptozotocin-Induced Diabetic Mice and Human Pluripotent Stem Cell-Derived Alveolar Organoids Biomedicines doi: 10.3390/biomedicines8090346 Authors: Roya Rasaei Eunbi Kim Ji-Young Kim Sunghun Na Jung-Hyun Kim Jinbeom Heo Dong-Myung Shin Sun Shim Choi Seok-Ho Hong Hyperglycemia is a causative factor in the pathogenesis of respiratory diseases, known to induce fibrosis and inflammation...
Fri Sep 11, 2020 03:00
Biomedicines, Vol. 8, Pages 344: Inflammation in Dry Eye Syndrome: Identification and Targeting of Oxylipin-Mediated Mechanisms Biomedicines doi: 10.3390/biomedicines8090344 Authors: Dmitry V. Chistyakov Olga S. Gancharova Viktoriia E. Baksheeva Veronika V. Tiulina Sergei V. Goriainov Nadezhda V. Azbukina Marina S. Tsarkova Andrey A. Zamyatnin Pavel P. Philippov Marina G. Sergeeva Ivan I. Senin Evgeni Yu. Zernii Dry eye syndrome (DES) is characterized...
Fri Sep 11, 2020 03:00
Biomedicines, Vol. 8, Pages 345: Identification of Toxicity Parameters Associated with Combustion Produced Soot Surface Chemistry and Particle Structure by in Vitro Assays Biomedicines doi: 10.3390/biomedicines8090345 Authors: Heba Al Housseiny Madhu Singh Shaneeka Emile Marvin Nicoleau Randy L. Vander Wal Patricia Silveyra Air pollution has become the world’s single biggest environmental health risk of the past decade, causing millions of yearly deaths worldwide....
Fri Sep 11, 2020 03:00
Biomedicines, Vol. 8, Pages 343: Type 1 Diabetes Induces Hearing Loss: Functional and Histological Findings in An Akita Mouse Model Biomedicines doi: 10.3390/biomedicines8090343 Authors: Yun Yeong Lee Yeon Ju Kim Eun Sol Gil Hantai Kim Jeong Hun Jang Yun-Hoon Choung The relationship between type 1 diabetes and hearing loss is not well known, although based on many pathological studies, type 2 diabetes induced hearing loss is associated with microcirculation problems in...
Fri Sep 11, 2020 03:00
Biomimetics, Vol. 5, Pages 44: Finite Element Analysis of Orthopedic Hip Implant with Functionally Graded Bioinspired Lattice Structures Biomimetics doi: 10.3390/biomimetics5030044 Authors: Nikolaos Kladovasilakis Konstantinos Tsongas Dimitrios Tzetzis The topology optimization (TO) process has the objective to structurally optimize products in various industries, such as in biomechanical engineering. Additive manufacturing facilitates this procedure and enables the utility of...
Sat Sep 12, 2020 03:00
Biomolecules, Vol. 10, Pages 1316: Regulation of p27Kip1 and p57Kip2 Functions by Natural Polyphenols Biomolecules doi: 10.3390/biom10091316 Authors: Gian Luigi Russo Emanuela Stampone Carmen Cervellera Adriana Borriello In numerous instances, the fate of a single cell not only represents its peculiar outcome but also contributes to the overall status of an organism. In turn, the cell division cycle and its control strongly influence cell destiny, playing a critical role in...
Sun Sep 13, 2020 03:00
Biomolecules, Vol. 10, Pages 1315: Effects of Experimental Agents Containing Tannic Acid or Chitosan on the Bacterial Biofilm Formation in Situ Biomolecules doi: 10.3390/biom10091315 Authors: Anton Schestakow Matthias Hannig Chitosan and tannic acid are known for their antibacterial properties. In the present in-situ study, their antibacterial and anti-adherent effects on biofilm formation on enamel were investigated. Six subjects carried upper jaw splints with bovine enamel specimens,...
Sat Sep 12, 2020 03:00
Biomolecules, Vol. 10, Pages 1314: Structural Models for the Dynamic Effects of Loss-of-Function Variants in the Human SIM1 Protein Transcriptional Activation Domain Biomolecules doi: 10.3390/biom10091314 Authors: Mathew A. Coban Patrick R. Blackburn Murray L. Whitelaw Mieke M. van Haelst Paldeep S. Atwal Thomas R. Caulfield Single-minded homologue 1 (SIM1) is a transcription factor with numerous different physiological and developmental functions. SIM1 is a member of...
Sat Sep 12, 2020 03:00
Biomolecules, Vol. 10, Pages 1313: A Phosphorylation-Induced Switch in the Nuclear Localization Sequence of the Intrinsically Disordered NUPR1 Hampers Binding to Importin Biomolecules doi: 10.3390/biom10091313 Authors: José L. Neira Bruno Rizzuti Ana Jiménez-Alesanco Martina Palomino-Schätzlein Olga Abián Adrián Velázquez-Campoy Juan L. Iovanna Several carrier proteins are involved in protein transport from the cytoplasm to the nucleus in eukaryotic cells. One of those...
Fri Sep 11, 2020 03:00
Biomolecules, Vol. 10, Pages 1311: Determining the Molecular Background of Endometrial Receptivity in Adenomyosis Biomolecules doi: 10.3390/biom10091311 Authors: Erika Prašnikar Tanja Kunej Jure Knez Katja Repnik Uroš Potočnik Borut Kovačič Background: Adenomyosis is a gynaecological condition with limited evidence of negative impact to endometrial receptivity. It is commonly associated with endometriosis, which has been shown to alter endometrial expression patterns....
Fri Sep 11, 2020 03:00
Biomolecules, Vol. 10, Pages 1312: Why COVID-19 Transmission Is More Efficient and Aggressive Than Viral Transmission in Previous Coronavirus Epidemics? Biomolecules doi: 10.3390/biom10091312 Authors: Fatma Elrashdy Elrashdy M. Redwan Vladimir N. Uversky Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing a pandemic of coronavirus disease 2019 (COVID-19). The worldwide transmission of COVID-19 from human to human is spreading like wildfire, affecting almost...
Fri Sep 11, 2020 03:00
Biomolecules, Vol. 10, Pages 1310: Dynamic mRNP Remodeling in Response to Internal and External Stimuli Biomolecules doi: 10.3390/biom10091310 Authors: Kathi Zarnack Sureshkumar Balasubramanian Michael P. Gantier Vladislav Kunetsky Michael Kracht M. Lienhard Schmitz Katja Sträßer Signal transduction and the regulation of gene expression are fundamental processes in every cell. RNA-binding proteins (RBPs) play a key role in the post-transcriptional modulation of gene...
Fri Sep 11, 2020 03:00
Biomolecules, Vol. 10, Pages 1309: Effects of the Delta Opioid Receptor Agonist DADLE in a Novel Hypoxia-Reoxygenation Model on Human and Rat-Engineered Heart Tissue: A Pilot Study Biomolecules doi: 10.3390/biom10091309 Authors: Sandra Funcke Tessa R. Werner Marc Hein Bärbel M. Ulmer Arne Hansen Thomas Eschenhagen Marc N. Hirt Intermittent hypoxia and various pharmacological compounds protect the heart from ischemia reperfusion injury in experimental approaches, but...
Fri Sep 11, 2020 03:00
Biosensors, Vol. 10, Pages 125: Screen-Printed Glucose Sensors Modified with Cellulose Nanocrystals (CNCs) for Cell Culture Monitoring Biosensors doi: 10.3390/bios10090125 Authors: Ye Tang Konstantinos Petropoulos Felix Kurth Hui Gao Davide Migliorelli Olivier Guenat Silvia Generelli Glucose sensors are potentially useful tools for monitoring the glucose concentration in cell culture medium. Here, we present a new, low-cost, and reproducible sensor based on a cellulose-based...
Sun Sep 13, 2020 03:00
Biosensors, Vol. 10, Pages 124: Robust Single-Trial EEG-Based Authentication Achieved with a 2-Stage Classifier Biosensors doi: 10.3390/bios10090124 Authors: Uladzislau Barayeu Nastassya Horlava Arno Libert Marc Van Hulle The risk of personal data exposure through unauthorized access has never been as imminent as today. To counter this, biometric authentication has been proposed: the use of distinctive physiological and behavioral characteristics as a form of identification...
Sun Sep 13, 2020 03:00
Biosensors, Vol. 10, Pages 123: Screen-Printed Sensor for Low-Cost Chloride Analysis in Sweat for Rapid Diagnosis and Monitoring of Cystic Fibrosis Biosensors doi: 10.3390/bios10090123 Authors: Alicia Hauke Susanne Oertel Leona Knoke Vanessa Fein Christoph Maier Folke Brinkmann Michael P. M. Jank Analysis of sweat chloride levels in cystic fibrosis (CF) patients is essential not only for diagnosis but also for the monitoring of therapeutic responses to new drugs, such...
Fri Sep 11, 2020 03:00
Biosensors, Vol. 10, Pages 122: Silver-Based SERS Pico-Molar Adenine Sensor Biosensors doi: 10.3390/bios10090122 Authors: Yonhua Tzeng Bo-Yi Lin Adenine is an important molecule for biomedical and agricultural research and applications. The detection of low concentration adenine molecules is thus desirable. Surface-enhanced Raman scattering (SERS) is a promising label-free detection and fingerprinting technique for molecules of significance. A novel SERS sensor made of clusters of...
Fri Sep 11, 2020 03:00
Brain Sciences, Vol. 10, Pages 633: Recent Advances and Future Perspectives in the Development of Therapeutic Approaches for Neurodegenerative Diseases Brain Sciences doi: 10.3390/brainsci10090633 Authors: Melissa Bowerman Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD), severely impact the function of neuronal cells in the brain and have devastating consequences on the quality of life of...
Fri Sep 11, 2020 03:00
Brain Sciences, Vol. 10, Pages 630: Immunohistochemical Evidence for Glutamatergic Regulation of Nesfatin-1 Neurons in the Rat Hypothalamus Brain Sciences doi: 10.3390/brainsci10090630 Authors: Duygu Gok Yurtseven Sema Serter Kocoglu Zehra Minbay Ozhan Eyigor Nesfatin-1, identified as an anorexigenic peptide, regulates the energy metabolism by suppressing food intake. The majority of nesfatin-1-synthesizing neurons are concentrated in various hypothalamic nuclei, especially...
Fri Sep 11, 2020 03:00
Brain Sciences, Vol. 10, Pages 634: Levetiracetam Reduced the Basal Excitability of the Dentate Gyrus without Restoring Impaired Synaptic Plasticity in Rats with Temporal Lobe Epilepsy Brain Sciences doi: 10.3390/brainsci10090634 Authors: Guillermo González-H Itzel Jatziri Contreras-García Karla Sánchez-Huerta Claudio M. T. Queiroz Luis Ricardo Gallardo Gudiño Julieta G. Mendoza-Torreblanca Sergio R. Zamudio Temporal lobe epilepsy (TLE), the most common type of focal...
Fri Sep 11, 2020 03:00
Brain Sciences, Vol. 10, Pages 629: Response to Placebo in Fragile X Syndrome Clinical Trials: An Initial Analysis Brain Sciences doi: 10.3390/brainsci10090629 Authors: Skylar Luu Haley Province Elizabeth Berry-Kravis Randi Hagerman David Hessl Dhananjay Vaidya Reymundo Lozano Hilary Rosselot Craig Erickson Walter E. Kaufmann Dejan B. Budimirovic Fragile X syndrome (FXS) is the leading cause of inherited intellectual disability and autism spectrum disorder....
Fri Sep 11, 2020 03:00
Brain Sciences, Vol. 10, Pages 631: Analyzing the Potential Biological Determinants of Autism Spectrum Disorder: From Neuroinflammation to the Kynurenine Pathway Brain Sciences doi: 10.3390/brainsci10090631 Authors: Rosa Savino Marco Carotenuto Anna Nunzia Polito Sofia Di Noia Marzia Albenzio Alessia Scarinci Antonio Ambrosi Francesco Sessa Nicola Tartaglia Giovanni Messina Autism Spectrum Disorder (ASD) etiopathogenesis is still unclear and no effective preventive...
Fri Sep 11, 2020 03:00
Brain Sciences, Vol. 10, Pages 632: Developing Employment Environments Where Individuals with ASD Thrive: Using Machine Learning to Explore Employer Policies and Practices Brain Sciences doi: 10.3390/brainsci10090632 Authors: Amy Jane Griffiths Amy Hurley Hanson Cristina M. Giannantonio Sneha Kohli Mathur Kayleigh Hyde Erik Linstead An online survey instrument was developed to assess employers’ perspectives on hiring job candidates with Autism Spectrum Disorder...
Fri Sep 11, 2020 03:00
Cancers, Vol. 12, Pages 2615: Unwanted Hormonal and Metabolic Effects of Postoperative Adjuvant Mitotane Treatment for Adrenocortical Cancer Cancers doi: 10.3390/cancers12092615 Authors: Vittoria Basile Soraya Puglisi Anna Calabrese Anna Pia Paola Perotti Alfredo Berruti Giuseppe Reimondo Massimo Terzolo Mitotane is widely used for the treatment of adrenocortical cancer (ACC), although the drug-related toxicity complicates its use. The aim of this study is to assess...
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Cancers, Vol. 12, Pages 2616: Comprehensive Analysis of MEN1 Mutations and Their Role in Cancer Cancers doi: 10.3390/cancers12092616 Authors: Devi D. Nelakurti Amrit L. Pappula Swetha Rajasekaran Wayne O. Miles Ruben C. Petreaca MENIN is a scaffold protein encoded by the MEN1 gene that functions in multiple biological processes, including cell proliferation, migration, gene expression, and DNA damage repair. MEN1 is a tumor suppressor gene, and mutations that disrupts MEN1...
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Cancers, Vol. 12, Pages 2614: High M-MDSC Percentage as a Negative Prognostic Factor in Chronic Lymphocytic Leukaemia Cancers doi: 10.3390/cancers12092614 Authors: Michał Zarobkiewicz Wioleta Kowalska Sylwia Chocholska Waldemar Tomczak Agata Szymańska Izabela Morawska Agnieszka Wojciechowska Agnieszka Bojarska-Junak In the current study, we analysed the role and prognostic value of myeloid-derived suppressor cells (MDSC) in chronic lymphocytic leukaemia (CLL). The...
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Cancers, Vol. 12, Pages 2613: DNA Polymerase Alpha Subunit B Is a Binding Protein for Erlotinib Resistance in Non-Small Cell Lung Cancer Cancers doi: 10.3390/cancers12092613 Authors: Tae Young Kim Eun Sun Ji Ju Yeon Lee Jin Young Kim Jong Shin Yoo A. Marcell Szasz Balazs Dome Gyorgy Marko-Varga Ho Jeong Kwon Erlotinib inhibits epithelial growth factor receptor (EGFR) kinase activity and is used to treat non-small cell lung cancer (NSCLC). Despite its high efficacy,...
Sun Sep 13, 2020 03:00
Cancers, Vol. 12, Pages 2611: Functional Mapping before and after Low-Grade Glioma Surgery: A New Way to Decipher Various Spatiotemporal Patterns of Individual Neuroplastic Potential in Brain Tumor Patients Cancers doi: 10.3390/cancers12092611 Authors: Hugues Duffau Intraoperative direct electrostimulation mapping (DEM) is currently the gold-standard for glioma surgery, since functional-based resection allows an optimization of the onco-functional balance (increased resection with preserved...
Sun Sep 13, 2020 03:00
Cancers, Vol. 12, Pages 2612: CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19+HLA-C1− Malignant B Cells While Sparing CD19+HLA-C1+ Healthy B Cells Cancers doi: 10.3390/cancers12092612 Authors: Lei Tao Muhammad Asad Farooq Yaoxin Gao Li Zhang Congyi Niu Iqra Ajmal Ying Zhou Cong He Guixia Zhao Jie Yao Mingyao Liu Wenzheng Jiang B cell aplasia caused by “on-target off-tumor” toxicity is one of the clinical side...
Sun Sep 13, 2020 03:00
Cancers, Vol. 12, Pages 2609: Bone and Soft Tissue Sarcoma Cancers doi: 10.3390/cancers12092609 Authors: Antonio Ruggiero Bone and soft-tissue sarcomas are relatively rare tumors both in children and adults [...]
Sat Sep 12, 2020 03:00
Cancers, Vol. 12, Pages 2608: The Prognostic Value of MicroRNAs in Thyroid Cancers—A Systematic Review and Meta-Analysis Cancers doi: 10.3390/cancers12092608 Authors: Silaghi Lozovanu Silaghi Georgescu Pop Dobrean Georgescu Thyroid cancer (TC) includes various phenotypes, from indolent to highly aggressive cancer. The limitations of the current prognostication systems to predict the recurrence risk and the variability in expression of the genes involved in the...
Sat Sep 12, 2020 03:00
Cancers, Vol. 12, Pages 2610: Triage May Improve Selection to Colonoscopy and Reduce the Number of Unnecessary Colonoscopies Cancers doi: 10.3390/cancers12092610 Authors: M. Petersen Ferm Kleif Piper Rømer Christensen Nielsen ：Implementation of population screening for colorectal cancer by direct colonoscopy or follow-up colonoscopy after a positive fecal blood test has challenged the overall capacity of bowel examinations. Certain countries are facing serious...
Sat Sep 12, 2020 03:00
Cancers, Vol. 12, Pages 2607: The Origin and Immune Recognition of Tumor-Specific Antigens Cancers doi: 10.3390/cancers12092607 Authors: Anca Apavaloaei Marie-Pierre Hardy Pierre Thibault Claude Perreault The dominant paradigm holds that spontaneous and therapeutically induced anti-tumor responses are mediated mainly by CD8 T cells and directed against tumor-specific antigens (TSAs). The presence of specific TSAs on cancer cells can only be proven by mass spectrometry analyses....
Sat Sep 12, 2020 03:00
Cancers, Vol. 12, Pages 2606: Organotypic Culture of Acinar Cells for the Study of Pancreatic Cancer Initiation Cancers doi: 10.3390/cancers12092606 Authors: Carlotta Paoli Alessandro Carrer The carcinogenesis of pancreatic ductal adenocarcinoma (PDA) progresses according to multi-step evolution, whereby the disease acquires increasingly aggressive pathological features. On the other hand, disease inception is poorly investigated. Decoding the cascade of events that leads to oncogenic...
Sat Sep 12, 2020 03:00
Cancers, Vol. 12, Pages 2605: Cellular Mechanisms Accounting for the Refractoriness of Colorectal Carcinoma to Pharmacological Treatment Cancers doi: 10.3390/cancers12092605 Authors: Jose J.G. Marin Rocio I.R. Macias Maria J. Monte Elisa Herraez Ana Peleteiro-Vigil Beatriz Sanchez de Blas Paula Sanchon-Sanchez Alvaro G. Temprano Ricardo A. Espinosa-Escudero Elisa Lozano Oscar Briz Marta R. Romero The unsatisfactory response of colorectal cancer (CRC)...
Fri Sep 11, 2020 03:00
Cancers, Vol. 12, Pages 2603: Inhibition of Caspases Improves Non-Viral T Cell Receptor Editing Cancers doi: 10.3390/cancers12092603 Authors: Chunxi Wang Chun-Chi Chang Liangli Wang Fan Yuan T cell receptor (TCR) knockout is a critical step in producing universal chimeric antigen receptor T cells for cancer immunotherapy. A promising approach to achieving the knockout is to deliver the CRISPR/Cas9 system into cells using electrotransfer technology. However, clinical applications...
Fri Sep 11, 2020 03:00
Cancers, Vol. 12, Pages 2602: Incidence of Hepatocellular Carcinoma after Treatment with Sofosbuvir-Based or Sofosbuvir-Free Regimens in Patients with Chronic Hepatitis C Cancers doi: 10.3390/cancers12092602 Authors: Eiichi Ogawa Hideyuki Nomura Makoto Nakamuta Norihiro Furusyo Eiji Kajiwara Kazufumi Dohmen Akira Kawano Aritsune Ooho Koichi Azuma Kazuhiro Takahashi Takeaki Satoh Toshimasa Koyanagi Yasunori Ichiki Masami Kuniyoshi Kimihiko Yanagita...
Fri Sep 11, 2020 03:00
Cancers, Vol. 12, Pages 2601: Phosphorylation of OCT4 Serine 236 Inhibits Germ Cell Tumor Growth by Inducing Differentiation Cancers doi: 10.3390/cancers12092601 Authors: Dong-Keon Kim Bomin Song Suji Han Hansol Jang Seung-Hyun Bae Hee Yeon Kim Seon-Hyeong Lee Seungjin Lee Jong Kwang Kim Han-Seong Kim Kyeong-Man Hong Byung Il Lee Hong-Duk Youn Soo-Youl Kim Sang Won Kang Hyonchol Jang Octamer-binding transcription factor 4 (Oct4) plays an important...
Fri Sep 11, 2020 03:00
Cancers, Vol. 12, Pages 2604: Molecular Classification of Endometrial Stromal Sarcomas Using RNA Sequencing Defines Nosological and Prognostic Subgroups with Different Natural History Cancers doi: 10.3390/cancers12092604 Authors: Mehdi Brahmi Tatiana Franceschi Isabelle Treilleux Daniel Pissaloux Isabelle Ray-Coquard Armelle Dufresne Helene Vanacker Melodie Carbonnaux Pierre Meeus Marie-Pierre Sunyach Amine Bouhamama Marie Karanian Alexandra Meurgey Jean-Yves...
Fri Sep 11, 2020 03:00
Cancers, Vol. 12, Pages 2599: Recent Progress in the Systemic Treatment of Advanced/Metastatic Cholangiocarcinoma Cancers doi: 10.3390/cancers12092599 Authors: Raluca Maria Fostea Elisa Fontana Gonzalo Torga Hendrik-Tobias Arkenau Cholangiocarcinomas (CCAs) comprise of a heterogeneous group of cancers arising in the biliary tract (intrahepatic or iCCA, perihilar or pCCA and distal or dCCA; the latter are known under the collective term of eCCA), each subtype having its own particularities...
Fri Sep 11, 2020 03:00
Cancers, Vol. 12, Pages 2595: New Insights into Breast and Endometrial Cancers Cancers doi: 10.3390/cancers12092595 Authors: Yasuhiro Miki Cancers of the breast and endometrium are some of the most common cancers affecting women [...]
Fri Sep 11, 2020 03:00
Cancers, Vol. 12, Pages 2598: Multimodality Treatment in Metastatic Gastric Cancer: From Past to Next Future Cancers doi: 10.3390/cancers12092598 Authors: Alessandro Parisi Giampiero Porzio Corrado Ficorella Gastric cancer (GC) still remains an incurable disease in almost two-thirds of the cases. However, a deeper knowledge of its biology in the last few years has revealed potential biomarkers suitable for tailored treatment with targeted agents. This aspect, together with the...
Fri Sep 11, 2020 03:00
Cancers, Vol. 12, Pages 2597: Nucleic Acids in Cancer Diagnosis and Therapy Cancers doi: 10.3390/cancers12092597 Authors: Taewan Kim Cancer research has been focused on the coding genes occupying 1–2% of the human genome [...]
Fri Sep 11, 2020 03:00
Cancers, Vol. 12, Pages 2594: L-Arginine/Nitric Oxide Pathway Is Altered in Colorectal Cancer and Can Be Modulated by Novel Derivatives from Oxicam Class of Non-Steroidal Anti-Inflammatory Drugs Cancers doi: 10.3390/cancers12092594 Authors: Małgorzata Krzystek-Korpacka Berenika Szczęśniak-Sięga Izabela Szczuka Paulina Fortuna Marek Zawadzki Agnieszka Kubiak Magdalena Mierzchała-Pasierb Mariusz G. Fleszar Łukasz Lewandowski Paweł Serek Natalia Jamrozik Katarzyna...
Fri Sep 11, 2020 03:00
Cancers, Vol. 12, Pages 2596: Pathophysiology and Imaging Findings of Bile Duct Necrosis: A Rare but Serious Complication of Transarterial Therapy for Liver Tumors Cancers doi: 10.3390/cancers12092596 Authors: Satoshi Kobayashi Kazuto Kozaka Toshifumi Gabata Osamu Matsui Wataru Koda Miho Okuda Kenichiro Okumura Takumi Sugiura Takahiro Ogi Bile duct necrosis (BDN) with biloma formation is a type of ischemic bile duct injury that is one of the serious complications...
Fri Sep 11, 2020 03:00
Cancers, Vol. 12, Pages 2600: Jagged Ligands Enhance the Pro-Angiogenic Activity of Multiple Myeloma Cells Cancers doi: 10.3390/cancers12092600 Authors: Maria Teresa Palano Domenica Giannandrea Natalia Platonova Germano Gaudenzi Monica Falleni Delfina Tosi Elena Lesma Valentina Citro Michela Colombo Ilaria Saltarella Roberto Ria Nicola Amodio Elisa Taiana Antonino Neri Giovanni Vitale Raffaella Chiaramonte Multiple myeloma (MM) is an incurable...
Fri Sep 11, 2020 03:00
Cancers, Vol. 12, Pages 2593: Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis Cancers doi: 10.3390/cancers12092593 Authors: Parastoo Shahrouzi Ianire Astobiza Ana R. Cortazar Verónica Torrano Alice Macchia Juana M. Flores Chiara Niespolo Isabel Mendizabal Ruben Caloto Amaia Ercilla Laura Camacho Leire Arreal Maider Bizkarguenaga Maria L. Martinez-Chantar Xose R. Bustelo Edurne Berra Endre Kiss-Toth Guillermo...
Fri Sep 11, 2020 03:00
Cancers, Vol. 12, Pages 2592: Heat Shock Proteins and PD-1/PD-L1 as Potential Therapeutic Targets in Myeloproliferative Neoplasms Cancers doi: 10.3390/cancers12092592 Authors: Steven De Almeida Mathilde Regimbeau Gaëtan Jego Carmen Garrido François Girodon François Hermetet Myeloproliferative neoplasms (MPN) are a group of clonal disorders that affect hematopoietic stem/progenitor cells. These disorders are often caused by oncogenic driver mutations associated with persistent...
Fri Sep 11, 2020 03:00
Cancers, Vol. 12, Pages 2590: A Mathematical Model of Average Dynamics in a Stem Cell Hierarchy Suggests the Combinatorial Targeting of Cancer Stem Cells and Progenitor Cells as a Potential Strategy against Tumor Growth Cancers doi: 10.3390/cancers12092590 Authors: Rodolfo Molina-Peña Juan Carlos Tudon-Martinez Osvaldo Aquines-Gutiérrez The cancer stem cell hypothesis states that tumors are maintained by a small subpopulation of stem-like cells, often called cancer stem cells (CSCs)...
Fri Sep 11, 2020 03:00
Cells, Vol. 9, Pages 2092: An Evolutionary Cancer Epigenetic Approach Revealed DNA Hypermethylation of Ultra-Conserved Non-Coding Elements in Squamous Cell Carcinoma of Different Mammalian Species Cells doi: 10.3390/cells9092092 Authors: Luca Morandi Silvia Sabattini Andrea Renzi Antonella Rigillo Giuliano Bettini Eva Dervas Alexandria Schauer Marco Morandi Davide B. Gissi Achille Tarsitano Stefania Evangelisti Caterina Tonon Background: Ultra-conserved...
Sun Sep 13, 2020 03:00
Cells, Vol. 9, Pages 2093: Dim Light at Night Induced Neurodegeneration and Ameliorative Effect of Curcumin Cells doi: 10.3390/cells9092093 Authors: Namgyal Chandan Sultan Aftab Ali Mehta El-Serehy Al-Misned Sarwat It is a well-known fact that following a proper routine light/dark or diurnal rhythm controls almost all biological processes. With the introduction of modern lighting and artificial illumination systems, continuous exposure to light at night...
Sun Sep 13, 2020 03:00
Cells, Vol. 9, Pages 2091: BV-2 Microglial Cells Respond to Rotenone Toxic Insult by Modifying Pregnenolone, 5α-Dihydroprogesterone and Pregnanolone Levels Cells doi: 10.3390/cells9092091 Authors: Rossella Avallone Chiara Lucchi Giulia Puja Alessandro Codeluppi Monica Filaferro Giovanni Vitale Cecilia Rustichelli Giuseppe Biagini Neuroinflammation, whose distinctive sign is the activation of microglia, is supposed to play a key role in the development and progression...
Sun Sep 13, 2020 03:00
Cells, Vol. 9, Pages 2090: Ionocytes and CFTR Chloride Channel Expression in Normal and Cystic Fibrosis Nasal and Bronchial Epithelial Cells Cells doi: 10.3390/cells9092090 Authors: Paolo Scudieri Ilaria Musante Arianna Venturini Daniela Guidone Michele Genovese Federico Cresta Emanuela Caci Alessandro Palleschi Marco Poeta Francesca Santamaria Fabiana Ciciriello Vincenzina Lucidi Luis J. V. Galietta The airway epithelium contains ionocytes, a rare...
Sun Sep 13, 2020 03:00
Cells, Vol. 9, Pages 2087: Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells Cells doi: 10.3390/cells9092087 Authors: Matthias Krumb Marie-Luise Frey Jens Langhanki Robert Forster Danuta Kowalczyk Volker Mailänder Katharina Landfester Till Opatz Herein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl...
Sat Sep 12, 2020 03:00
Cells, Vol. 9, Pages 2089: Activation of Cdc42 GTPase upon CRY2-Induced Cortical Recruitment is Antagonized by GAPs in Fission Yeast Cells doi: 10.3390/cells9092089 Authors: Lamas Weber Martin The small GTPase Cdc42 is critical for cell polarization in eukaryotic cells. In rod-shaped fission yeast Schizosaccharomyces pombe cells, active GTP-bound Cdc42 promotes polarized growth at cell poles, while inactive Cdc42-GDP localizes ubiquitously also along cell sides. Zones of Cdc42...
Sat Sep 12, 2020 03:00
Cells, Vol. 9, Pages 2088: The Amazonian Red Side-Necked Turtle Rhinemys rufipes (Spix, 1824) (Testudines, Chelidae) Has a GSD Sex-Determining Mechanism with an Ancient XY Sex Microchromosome System Cells doi: 10.3390/cells9092088 Authors: Patrik F. Viana Eliana Feldberg Marcelo B. Cioffi Vinicius Tadeu de Carvalho Sabrina Menezes Richard C. Vogt Thomas Liehr Tariq Ezaz The Amazonian red side-necked turtle Rhynemis rufipes is an endemic Amazonian Chelidae species...
Sat Sep 12, 2020 03:00
Cells, Vol. 9, Pages 2085: Development of Feline Ileum- and Colon-Derived Organoids and Their Potential Use to Support Feline Coronavirus Infection Cells doi: 10.3390/cells9092085 Authors: Gergely Tekes Rosina Ehmann Steeve Boulant Megan L. Stanifer Feline coronaviruses (FCoVs) infect both wild and domestic cat populations world-wide. FCoVs present as two main biotypes: the mild feline enteric coronavirus (FECV) and the fatal feline infectious peritonitis virus (FIPV). FIPV...
Sat Sep 12, 2020 03:00
Cells, Vol. 9, Pages 2086: Sexual Dimorphism in Osteoclasts Cells doi: 10.3390/cells9092086 Authors: Joseph Lorenzo Osteoclasts are the principal mediators of bone resorption. They form through the fusion of mononuclear precursor cells under the principal influence of the cytokines macrophage colony stimulating factor (M-CSF, aka CSF-1) and receptor activator of NF-κB ligand (RANKL, aka TNFSF11). Sexual dimorphism in the development of the skeleton and in the incidence of skeletal...
Sat Sep 12, 2020 03:00
Cells, Vol. 9, Pages 2084: Quantification of Boron Compound Concentration for BNCT Using Positron Emission Tomography Cells doi: 10.3390/cells9092084 Authors: Marcin Balcerzyk Manuel De-Miguel Carlos Guerrero Begoña Fernandez Background: Boron neutron capture therapy requires a 2 mM 10B concentration in the tumor. The well-known BNCT patient treatment method using boronophenylalanine (BPA) as a boron-carrying agent utilizes [18F]fluoroBPA ([18F]FBPA) as an agent to qualify for...
Sat Sep 12, 2020 03:00
Cells, Vol. 9, Pages 2081: Metabolic Constrains Rule Metastasis Progression Cells doi: 10.3390/cells9092081 Authors: Niccolo’ Roda Valentina Gambino Marco Giorgio Metastasis formation accounts for the majority of tumor-associated deaths and consists of different steps, each of them being characterized by a distinctive adaptive phenotype of the cancer cells. Metabolic reprogramming represents one of the main adaptive phenotypes exploited by cancer cells during all the main steps...
Fri Sep 11, 2020 03:00
Cells, Vol. 9, Pages 2082: Intravitreal Co-Administration of GDNF and CNTF Confers Synergistic and Long-Lasting Protection against Injury-Induced Cell Death of Retinal Ganglion Cells in Mice Cells doi: 10.3390/cells9092082 Authors: Simon Dulz Mahmoud Bassal Kai Flachsbarth Kristoffer Riecken Boris Fehse Stefanie Schlichting Susanne Bartsch Udo Bartsch We have recently demonstrated that neural stem cell-based intravitreal co-administration of glial cell line-derived...
Fri Sep 11, 2020 03:00
Cells, Vol. 9, Pages 2083: FAM64A: A Novel Oncogenic Target of Lung Adenocarcinoma Regulated by Both Strands of miR-99a (miR-99a-5p and miR-99a-3p) Cells doi: 10.3390/cells9092083 Authors: Keiko Mizuno Kengo Tanigawa Nijiro Nohata Shunsuke Misono Reona Okada Shunichi Asai Shogo Moriya Takayuki Suetsugu Hiromasa Inoue Naohiko Seki Lung adenocarcinoma (LUAD) is the most aggressive cancer and the prognosis of these patients is unfavorable. We revealed that the...
Fri Sep 11, 2020 03:00
Cells, Vol. 9, Pages 2077: Endocrine Resistance in Breast Cancer: The Role of Estrogen Receptor Stability Cells doi: 10.3390/cells9092077 Authors: Sarah A. Jeffreys Branka Powter Bavanthi Balakrishnar Kelly Mok Patsy Soon André Franken Hans Neubauer Paul de Souza Therese M. Becker Therapy of hormone receptor positive breast cancer (BCa) generally targets estrogen receptor (ER) function and signaling by reducing estrogen production or by blocking its interaction...
Fri Sep 11, 2020 03:00
Cells, Vol. 9, Pages 2080: Ribosomopathies: New Therapeutic Perspectives Cells doi: 10.3390/cells9092080 Authors: Emilien Orgebin François Lamoureux Bertrand Isidor Céline Charrier Benjamin Ory Frédéric Lézot Marc Baud’huin Ribosomopathies are a group of rare diseases in which genetic mutations cause defects in either ribosome biogenesis or function, given specific phenotypes. Ribosomal proteins, and multiple other factors that are necessary for ribosome biogenesis...
Fri Sep 11, 2020 03:00
Cells, Vol. 9, Pages 2076: Retinoic Acid Improves the Recovery of Replication-Competent Virus from Latent SIV Infected Cells Cells doi: 10.3390/cells9092076 Authors: Omalla A. Olwenyi Arpan Acharya Nanda Kishore Routhu Keely Pierzchalski Jace W. Jones Maureen A. Kane Neil Sidell Mahesh Mohan Siddappa N. Byrareddy The accurate estimation and eradication of Human Immunodeficiency Virus (HIV) viral reservoirs is limited by the incomplete reactivation of cells harboring...
Fri Sep 11, 2020 03:00
Cells, Vol. 9, Pages 2078: Oligodendrocyte Physiology and Pathology Function Cells doi: 10.3390/cells9092078 Authors: Markus Kipp The adult vertebrate central nervous system (CNS) mainly consists of neurons, astrocytes, microglia cells and oligodendrocytes [...]
Fri Sep 11, 2020 03:00
Cells, Vol. 9, Pages 2075: Stem Cell Repair of the Microvascular Damage in Stroke Cells doi: 10.3390/cells9092075 Authors: Madeline Saft Bella Gonzales-Portillo You Jeong Park Blaise Cozene Nadia Sadanandan Justin Cho Svitlana Garbuzova-Davis Cesar V. Borlongan Stroke is a life-threatening disease that leads to mortality, with survivors subjected to long-term disability. Microvascular damage is implicated as a key pathological feature, as well as a therapeutic target...
Fri Sep 11, 2020 03:00
Cells, Vol. 9, Pages 2079: On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little Cells doi: 10.3390/cells9092079 Authors: Michal Santocki Elzbieta Kolaczkowska Although neutrophil extracellular traps (NETs) were discovered only 16 years ago, they have already taken us from heaven to hell as we learned that apart from beneficial trapping of pathogens, they cause, or contribute to, numerous disorders. The latter is connected to their persistent presence...
Fri Sep 11, 2020 03:00
Children, Vol. 7, Pages 134: Understanding School-Aged Childhood Obesity of Body Mass Index: Application of the Social-Ecological Framework Children doi: 10.3390/children7090134 Authors: Keeyoon Noh Jihyun Jane Min In order to understand the prevalence of school-aged childhood obesity in the United States and suggest better methods to prevent and treat the public health problem, we examined it with significant and identifiable factors within the social-ecological model. To investigate...
Sun Sep 13, 2020 03:00
Diagnostics, Vol. 10, Pages 692: Association between EGFR Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer Diagnostics doi: 10.3390/diagnostics10090692 Authors: Ching-Hsiung Lin Po-Jen Yang Sheng-Hao Lin Kun-Tu Yeh Thomas Chang-Yao Tsao Yu-En Chen Shu-Hui Lin Shun-Fa Yang EGFR mutation status is considered as an important predictor of therapeutic responsiveness in non-small-cell lung carcinoma patients. Recent evidence suggests that antioxidant...
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Diagnostics, Vol. 10, Pages 691: Diagnosing Organic Causes of Schizophrenia Spectrum Disorders: Findings from a One-Year Cohort of the Freiburg Diagnostic Protocol in Psychosis (FDPP) Diagnostics doi: 10.3390/diagnostics10090691 Authors: Dominique Endres Miriam Matysik Bernd Feige Nils Venhoff Tina Schweizer Maike Michel Sophie Meixensberger Kimon Runge Simon J. Maier Kathrin Nickel Karl Bechter Horst Urbach Katharina Domschke Ludger Tebartz van Elst...
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Diagnostics, Vol. 10, Pages 690: Simplified Submucosal Tunneling Biopsy Using Clip-With-Line Traction and Closure for Gastric Subepithelial Lesion Diagnostics doi: 10.3390/diagnostics10090690 Authors: Hideki Kobara Nobuya Kobayashi Noriko Nishiyama Naoya Tada Shintaro Fujihara Tsutomu Masaki Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) has emerged as a standard and convenient method for the sampling of subepithelial lesions (SELs). Immunohistological...
Sat Sep 12, 2020 03:00
Diagnostics, Vol. 10, Pages 687: The Conundrum of Poor Ovarian Response: From Diagnosis to Treatment
Diagnostics, Vol. 10, Pages 687: The Conundrum of Poor Ovarian Response: From Diagnosis to Treatment Diagnostics doi: 10.3390/diagnostics10090687 Authors: Polina Giannelou Mara Simopoulou Sokratis Grigoriadis Evangelos Makrakis Adamantia Kontogeorgi Agni Pantou Dionysios Galatis Theodoros Kalampokas Panagiotis Bakas Stamatis Bolaris Konstantinos Pantos Konstantinos Sfakianoudis Despite recent striking advances in assisted reproductive technology (ART),...
Fri Sep 11, 2020 03:00
Diagnostics, Vol. 10, Pages 688: A Comprehensive Narrative Review on the Evolving Role of Endoscopic Ultrasound in Focal Solid Liver Lesions Diagnosis and Management Diagnostics doi: 10.3390/diagnostics10090688 Authors: Wisam Sbeit Anas Kadah Amir Mari Mahmud Mahamid Tawfik Khoury The implications of endoscopic ultrasound (EUS) have expanded considerably in recent years to cover more fields in invasive gastroenterology practice, as both an investigative and therapeutic modality....
Fri Sep 11, 2020 03:00
Diagnostics, Vol. 10, Pages 686: Long-Term Effects of Kasai Portoenterostomy for Biliary Atresia Treatment in Russia Diagnostics doi: 10.3390/diagnostics10090686 Authors: Anna Degtyareva Alexander Razumovskiy Nadezhda Kulikova Sergey Ratnikov Elena Filippova Ekaterina Gordeeva Marina Albegova Denis Rebrikov Anna Puchkova This prospective study enrolled 144 patients after surgical treatment of biliary atresia in early infancy. We analyzed the immediate effectiveness...
Fri Sep 11, 2020 03:00
Diagnostics, Vol. 10, Pages 689: The Prognostic Significance of Immune-Related Metabolic Enzyme MTHFD2 in Head and Neck Squamous Cell Carcinoma Diagnostics doi: 10.3390/diagnostics10090689 Authors: Li Cui Huan Chen Xinyuan Zhao Metabolic dysregulation has emerged as a crucial determinant of the clinical responses to immunotherapy. The aim of this study was to determine the clinical significance of the candidate immune-related metabolic enzymes (IRMEs) methylenetetrahydrofolate...
Fri Sep 11, 2020 03:00
Diagnostics, Vol. 10, Pages 685: Serum Neurofilament Light Chain Levels are Associated with Lower Thalamic Perfusion in Multiple Sclerosis Diagnostics doi: 10.3390/diagnostics10090685 Authors: Dejan Jakimovski Niels Bergsland Michael G. Dwyer Deepa P. Ramasamy Murali Ramanathan Bianca Weinstock-Guttman Robert Zivadinov Both perfusion-weighted imaging (PWI) measures and serum neurofilament light (sNfL) chain levels have been independently associated with disability in...
Fri Sep 11, 2020 03:00
Diagnostics, Vol. 10, Pages 684: Plasma Exosomal Brain-Derived Neurotrophic Factor Correlated with the Postural Instability and Gait Disturbance–Related Motor Symptoms in Patients with Parkinson’s Disease Diagnostics doi: 10.3390/diagnostics10090684 Authors: Chen Chih Chung Pai Hao Huang Lung Chan Jia-Hung Chen Li-Nien Chien Chien Tai Hong Brain-derived neurotrophic factor (BDNF) is an essential neurotrophin, responsible for neuronal development, function, and survival....
Fri Sep 11, 2020 03:00
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