Targeted therapeutic options and future perspectives for HER2-positive breast cancer. Signal Transduct Target Ther. 2019 Sep 13;4(1):34 Authors: Wang J, Xu B Abstract Over the past 2 decades, there has been an extraordinary progress in the regimens developed for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Trastuzumab, pertuzumab, lapatinib, and ado-trastuzumab emtansine (T-DM1) are commonly recommended...
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PSMA-PET identifies PCWG3 target populations with superior accuracy and reproducibility when compared to conventional imaging: a multicenter retrospective study. J Nucl Med. 2020 Sep 11;: Authors: Farolfi A, Hirmas N, Gafita A, Weber M, Barbato F, Wetter A, Mei R, Pianori D, Hadaschik B, Herrmann K, Castellucci P, Fanti S, Eiber M, Fendler WP Abstract Background: Prostate-specific membrane antigen (PSMA)-ligand positron-emission-tomography...
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Aggressive surgical approach in patients with adrenal-only metastases from hepatocellular carcinoma enables higher survival rates than standard systemic therapy. Hepatobiliary Pancreat Dis Int. 2020 Aug 31;: Authors: Alexandrescu ST, Croitoru AE, Grigorie RT, Tomescu DR, Droc G, Grasu MC, Popescu I Abstract BACKGROUND: Although guidelines recommend systemic therapy even in patients with limited extrahepatic metastases from hepatocellular carcinoma...
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Hospital-specific probability of cystectomy affects survival from muscle-invasive bladder cancer. Urol Oncol. 2020 Sep 08;: Authors: Ripping TM, Witjes JA, Meijer RP, van Rhijn BWG, Oddens JR, Goossens-Laan CA, Mulder SF, van Moorselaar RJA, Kiemeney LA, Aben KKH Abstract OBJECTIVES: Radical cystectomies (RCs) are increasingly centralized, but bladder cancer can be diagnosed in every hospital The aim of this study is to assess the variation...
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Epigenetic stratification of head and neck cancer survivors reveals differences in lycopene levels, alcohol consumption, and methylation of immune regulatory genes. Clin Epigenetics. 2020 Sep 11;12(1):138 Authors: Moody L, Crowder SL, Fruge AD, Locher JL, Demark-Wahnefried W, Rogers LQ, Delk-Licata A, Carroll WR, Spencer SA, Black M, Erdman JW, Chen H, Pan YX, Arthur AE Abstract BACKGROUND: Inflammation has been associated with higher rates...
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Overcoming immunotherapy resistance in non-small cell lung cancer (NSCLC) - novel approaches and future outlook. Mol Cancer. 2020 Sep 11;19(1):141 Authors: Horvath L, Thienpont B, Zhao L, Wolf D, Pircher A Abstract Immunotherapy (IO) has revolutionized the therapy landscape of non-small cell lung cancer (NSCLC), significantly prolonging the overall survival (OS) of advanced stage patients. Over the recent years IO therapy has been broadly integrated...
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Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches. Medicina (Kaunas). 2020 Sep 09;56(9): Authors: Filip L, Duică F, Prădatu A, Crețoiu D, Suciu N, Crețoiu SM, Predescu DV, Varlas VN, Voinea SC Abstract Endometriosis represents a frequently diagnosed gynecological affliction in the reproductive timespan of women, defined by symptoms ranging from pelvic pain to infertility. A complex...
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Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing. Int J Environ Res Public Health. 2020 Sep 09;17(18): Authors: Adam-Bonci TI, Cherecheș-Panța P, Bonci EA, Man SC, Cutaș-Benedec A, Drugan T, Pop RM, Irimie A Abstract Even though vitamin D is widely acknowledged as having a potential immunomodulatory role in asthma,...
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Rapid Cognitive Decline Secondary to CSF Venous Fistula With Postoperative Rebound Intracranial Hypertension and a Hyperintense Paraspinal Vein Sign Seen Retrospectively. Mil Med. 2020 Sep 12;: Authors: Tatum PS, Anderson E, Kravtsova A, Alnasser O, Hedges T, Green-Laroche DM, Madan N Abstract A 56-year-old female with 2 prior Chiari decompressions presented with rapidly progressive cognitive decline. Brain magnetic resonance imaging, computed...
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Simulated shift work during pregnancy does not impair progeny metabolic outcomes in sheep. J Physiol. 2020 Sep 12;: Authors: Gatford KL, Kennaway DJ, Liu H, Schultz CG, Wooldridge AL, Kuchel TR, Varcoe TJ Abstract KEY POINTS: Maternal shift work increases the risk of pregnancy complications, although its effects on progeny health after birth were not clear. We evaluated the impact of a simulated shift work protocol for one third, two thirds,...
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August Krogh's theory of muscle microvascular control and oxygen delivery: a paradigm shift based on new data. J Physiol. 2020 Sep 12;: Authors: Poole DC, Pittman RN, Musch TI, Østergaard L Abstract August Krogh twice won the prestigious international Steegen Prize, for nitrogen metabolism (1906) and overturning the concept of active transport of gases across the pulmonary epithelium (1910). Despite this, at the beginning of 1920, the consummate...
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The evolutionary causes of the latitudinal diversity gradient are debated. Hypotheses have ultimately invoked either faster rates of diversification in the tropics, or more time for diversification due to the tropical origins of higher taxa. Here we perform the first test of the diversification rate and time hypotheses in freshwater ray-finned fishes, a group comprising nearly a quarter of all living vertebrates. Using a mega-phylogeny of actinopterygian fishes and a global database of occurrence...
Sun Sep 13, 2020 03:00
British Journal of Cancer, Published online: 14 September 2020; doi:10.1038/s41416-020-01066-2Overcoming the blood–brain barrier by Annexin A1-binding peptide to target brain tumours
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British Journal of Cancer, Published online: 14 September 2020; doi:10.1038/s41416-020-01049-3Vascular aging in long-term survivors of testicular cancer more than 20 years after treatment with cisplatin-based chemotherapy
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British Journal of Cancer, Published online: 14 September 2020; doi:10.1038/s41416-020-01059-1Does insulin-like growth factor moderate the association between height and risk of cancer at 24 sites?
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The aim of this study is to explore the accuracy of two different approaches: transoral versus transnasal office-based laryngeal biopsy.
Sun Sep 13, 2020 03:00
Publication date: Available online 13 September 2020Source: Gait & PostureAuthor(s): Li Li
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Phantom-based quality assurance for multicenter quantitative MRI in locally advanced cervical cancer
Publication date: Available online 12 September 2020Source: Radiotherapy and OncologyAuthor(s): Petra J. van Houdt, Jesper F. Kallehauge, Kari Tanderup, Remi Nout, Marko Zaletelj, Tony Tadic, Zdenko J. van Kesteren, Cornelius A.T. van den Berg, Dietmar Georg, Jean-Charles Côté, Ives R. Levesque, Jamema Swamidas, Eirik Malinen, Sven Telliskivi, Patrik Brynolfsson, Faisal Mahmood, Uulke A. van der Heide, EMBRACE collaborative group
Sun Sep 13, 2020 23:50
The aim of this study was to highlight several misleading imaging and clinical aspects of parotid gland lymphoma, taking our personal experience and relevant literature reports into consideration. The records of all patients diagnosed with lymphoma in the parotid gland between 2005 and 2017 were examined retrospectively. Sixty-seven patients were included in this study. The mean age was 61.4 years. The most frequent histological entities were marginal zone B-cell lymphoma (31.3%) and follicular lymphoma...
Sun Sep 13, 2020 03:00
Homelessness is a global issue and HIV, hepatitis C and tuberculosis are known to be prevalent in this group. Homeless populations face significant barriers to care. We aim to summarise evidence of treatment i...
Sun Sep 13, 2020 03:00
Publication date: Available online 13 September 2020Source: Ultrasound in Medicine & BiologyAuthor(s): Susanne Rein, Khosrow Siamak Houschyar, Thorben Sterling-Hauf
Sun Sep 13, 2020 22:48
Publication date: Available online 12 September 2020Source: Journal of Neuroscience MethodsAuthor(s): Sibel Çimen Yetiş, Abdulkerim Çapar, Dursun A. Ekinci, Umut E. Ayten, Bilal E. Kerman, B. Uğur Töreyin
Sun Sep 13, 2020 22:31
Summary Background Androgen deprivation therapy (ADT) is a standard treatment for high-risk biochemically-recurrent, non-metastatic prostate cancer (BRPC) but is not curative and associated with toxicity. Racemetyrosine (SM-88) is an amino-acid analogue used with methoxsalen, phenytoin, and sirolimus (MPS) to enhance SM-88 activity. Method A phase 1b/2, open-label trial in BRPC and rising PSA. Patients were given daily SM-88 (230 mg BID), methoxsalen (10 mg), phenytoin (50 mg),...
Sun Sep 13, 2020 03:00
Brain metastases can occur in patients across a diverse range of cancer types [1]. Studies have shown that the incidence rate of brain metastases is approximately 20-40% and is rising [2–4]. Stereotactic radiosurgery (SRS) is a major treatment modality for patients with newly diagnosed brain metastases and the frequency of its use has increased [5–6]. SRS delivers highly focused and conformal radiation to brain metastases for effective treatment while sparing radiation exposure to the surrounding...
Sun Sep 13, 2020 03:00
Publication date: Available online 13 September 2020Source: American Journal of OtolaryngologyAuthor(s): Enrique Gorbea, David Y. Goldrich, Jay Agarwal, Roshan Nayak, Alfred Marc Iloreta
Sun Sep 13, 2020 21:22
Publication date: Available online 12 September 2020Source: American Journal of OtolaryngologyAuthor(s): Hongcun Sun, Cheng Cao, Xiaowen Qiu, Jiandao Hu, Jianyao Zhang
Sun Sep 13, 2020 21:22
Publication date: Available online 12 September 2020Source: American Journal of OtolaryngologyAuthor(s): Aboubakr Elshafey Ras, Mona Hosny Hamed, Abdelrahman Ahmed Abdelalim
Sun Sep 13, 2020 21:22
Publication date: Available online 12 September 2020Source: American Journal of OtolaryngologyAuthor(s): Robert Hutnik, Aaron Zlatopolsky, Sina Mehraban-Far, James Alrassi, Nadia McMillan, Chima Amadi, Kevin Fujita, Melissa Mortensen
Sun Sep 13, 2020 21:22
Publication date: Available online 12 September 2020Source: American Journal of OtolaryngologyAuthor(s): Farrokh Heidari, Firouzeh Heidari, Benyamin Rahmaty, Neda Jafari, Kayvan Aghazadeh, Saeed Sohrabpour, Ebrahim Karimi
Sun Sep 13, 2020 21:22
Publication date: Available online 12 September 2020Source: American Journal of OtolaryngologyAuthor(s): Alvaro Sanabria, Luiz P. Kowalski, Iain J. Nixon, Ashok Shaha, Remco De Bree, Antti A. Mäkitie, Alessandra Rinaldo, Alfio Ferlito
Sun Sep 13, 2020 21:22
Publication date: Available online 12 September 2020Source: American Journal of OtolaryngologyAuthor(s): Gautam Bir Singh, Nishant Arora, Shaili Tomar, Devanshu Kwatra, Sunil Kumar
Sun Sep 13, 2020 21:22
Publication date: Available online 12 September 2020Source: Magnetic Resonance ImagingAuthor(s): Jiabing Jiang, Jingyao Li, Zhiqiang Chu, Zhengzheng Tao, Wenjuan Cai, Jinxia Zhu, Robert Grimm, Qian Ji
Sun Sep 13, 2020 20:08
A linear low signal running transversely in L1 vertebral body through its whole sagittal diameter without marrow odema on STIR.It's a "Hahn cleft or canal", a normal anatomical variation of no clinical significance and is secondary to persistent nutrient artery and its canal, should not be mistaken for fracture.
Sun Sep 13, 2020 19:58
Publication date: December 2020Source: NeuroImage, Volume 223Author(s): Matthias Liebrand, Anke Karabanov, Daria Antonenko, Agnes Flöel, Hartwig R. Siebner, Joseph Classen, Ulrike M. Krämer, Elinor Tzvi
Sun Sep 13, 2020 19:22
Publication date: December 2020Source: NeuroImage, Volume 223Author(s): T.M. Raiser, V.L. Flanagin, M. Duering, A. van Ombergen, R.M. Ruehl, P. zu Eulenburg
Sun Sep 13, 2020 19:22
Publication date: Available online 13 September 2020Source: European Journal of Surgical OncologyAuthor(s): Sanne M. Jansen, Daniel M. de Bruin, Mark I. van Berge Henegouwen, Paul Bloemen, Simon D. Strackee, Denise Veelo, Ton G. van Leeuwen, Suzanne S. Gisbertz
Sun Sep 13, 2020 19:22
Publication date: Available online 12 September 2020Source: European Journal of Surgical OncologyAuthor(s): Zachariah Gene Wing Ow, Wilson Sim, Kameswara Rishi Yeshayahu Nistala, Cheng Han Ng, Frederick Hong-Xiang Koh, Neng Wei Wong, Fung Joon Foo, Ker-Kan Tan, Choon Seng Chong
Sun Sep 13, 2020 19:22
Publication date: Available online 12 September 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Jie Zhang, Maria J. Troulis, August Meredith
Sun Sep 13, 2020 18:55
Publication date: Available online 12 September 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Zeyneb Merve Ozdemir, Derya Surmelioglu
Sun Sep 13, 2020 18:48
Publication date: Available online 12 September 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Giancarlo Tirelli, Margherita Tofanelli, Erica Sacchet, Rossana Bussani, Vennus Shafiei, Annalisa Gatto, Paolo Boscolo-Rizzo, Nicoletta Gardenal
Sun Sep 13, 2020 18:33
Publication date: September 2020Source: Gene Expression Patterns, Volume 37Author(s):
Sun Sep 13, 2020 18:25
Publication date: September 2020Source: Gene Expression Patterns, Volume 37Author(s):
Sun Sep 13, 2020 18:25
Publication date: Available online 12 September 2020Source: World NeurosurgeryAuthor(s): Neeraj Kalra, Melissa Bautista, Helen McCullagh, Atul Tyagi
Sun Sep 13, 2020 17:55
Publication date: Available online 12 September 2020Source: World NeurosurgeryAuthor(s): Chunyi Yan, Tingkui Wu, Kangkang Huang, Junbo He, Hao Liu, Ying Hong, Beiyu Wang
Sun Sep 13, 2020 17:55
Publication date: Available online 12 September 2020Source: World NeurosurgeryAuthor(s): Rafael Ivan Neira, Kiyofumi Yamada, Manabu Shirakawa, Kazutaka Uchida, Shinichi Yoshimura
Sun Sep 13, 2020 17:55
Publication date: Available online 12 September 2020Source: Dental MaterialsAuthor(s): Thalita de Paris Matos, Jorge Perdigão, Eloisa de Paula, Fabiana Coppla, Viviane Hass, Rafael F. Scheffer, Alessandra Reis, Alessandro D. Loguercio
Sun Sep 13, 2020 17:50
Publication date: Available online 12 September 2020Source: Dental MaterialsAuthor(s): M.E. Draenert, C. Martini, D.C. Watts, K. Draenert, A. Wittig-Draenert
Sun Sep 13, 2020 17:50
Publication date: Available online 13 September 2020Source: Annals of Diagnostic PathologyAuthor(s): Francisco Vega, Catalina Amador, Amy Chadburn, Andrew L. Feldman, Eric D. Hsi, Wei Wang, L. Jeffrey Medeiros
Sun Sep 13, 2020 17:39
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Prince Allawadhi, Amit Khurana, Sachin Allwadhi, Uma Shanker Navik, Kamaldeep Joshi, Anil Kumar Banothu, Kala Kumar Bharani
Sun Sep 13, 2020 17:36
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Meenu Mehta, Parteek Prasher, Mousmee Sharma, Madhur D. Shastri, Navneet Khurana, Manish Vyas, Harish Dureja, Gaurav Gupta, Krishnan Anand, Saurabh Satija, Dinesh Kumar Chellappan, Kamal Dua
Sun Sep 13, 2020 17:36
Publication date: December 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 32Author(s): Arif Ullah Khan, Aziz ur Rahman, Qipeng Yuan, Aftab Ahmad, Zia Ul Haq Khan, Mater H. Mahnashi, Bandar A. Alyami, Yahya S. Alqahtani, Sadeeq Ullah, Adia Putra Wirman
Sun Sep 13, 2020 17:28
Publication date: December 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 32Author(s): Maria Cristina Modesto Clementino de Toledo, Alexandro da Silva Abreu, Janicy Arantes Carvalho, Jéssica Aparecida Ribeiro Ambrósio, Daniele da Silva Godoy, Bruna Cristina dos Santos Pinto, Milton Beltrame Junior, Andreza Ribeiro Simioni
Sun Sep 13, 2020 17:28
Publication date: December 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 32Author(s): L.F.C.S. Carvalho
Sun Sep 13, 2020 17:28
Publication date: November 2020Source: Archives of Oral Biology, Volume 119Author(s): Nada Alshihah, Adel Alhadlaq, Tarek El-Bialy, Abdullah Aldahmash, Ibrahim Bello
Sun Sep 13, 2020 17:02
Publication date: Available online 12 September 2020Source: Behavioural Brain ResearchAuthor(s): Erin Hart, Daniel Hertia, Scott T Barrett, Sergios Charntikov
Sun Sep 13, 2020 16:45
Purpose/Objective(s): The presence of coronary artery calcium (CAC>0) is associated with increased cardiac-related mortality and is a common indication to initiate statin therapy to prevent future long-term cardiac-related adverse events. CAC is also well visualized on noncontrast chest computed tomography simulation (CT sim) scans used for breast radiation planning. We hypothesize that by screening for incidental CAC on CT sims, radiation oncologists could help identify patients who may...
Fri Sep 11, 2020 03:00
Abstract Liver transplantation (LT) is a life-saving option for children with end-stage liver disease. However, about 50% of patients develop graft fibrosis in 1 year after LT, with normal liver function. Graft fibrosis may progress to cirrhosis, resulting in graft dysfunction and ultimately the need for re-transplantation. Previous studies have identified various risk factors for the post-LT fibrogenesis, however, to date, neither of the factors seems to fully explain the cause...
Sun Sep 13, 2020 03:00
Publication date: Available online 12 September 2020Source: Journal of the American College of SurgeonsAuthor(s): E Christopher Ellison, Kathryn Spanknebel, Steven C. Stain, Mohsen M. Shabahang, Jeffrey B. Mathews, Haile T. Debas, Alisa Nagler, Patrice Gabler Blair, Timothy J. Eberlein, Diana L. Farmer, Richard Sloane, L.D. Britt, Ajit K. Sachdeva
Sun Sep 13, 2020 16:30
Publication date: November 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 138Author(s): Virginia Corazzi, Andrea Ciorba, Chiara Bianchini, Monica Rosignoli, Laura Negossi, Federica Minazzi, Michela Borin, Nicola Malagutti, Francesco Stomeo, Stefano Pelucchi
Sun Sep 13, 2020 16:29
Publication date: Available online 12 September 2020Source: Journal of Surgical EducationAuthor(s): Lily N. Trinh, Erin O'Rorke, Mary K. Mulcahey
Sun Sep 13, 2020 16:10
Publication date: Available online 12 September 2020Source: Journal of Surgical EducationAuthor(s): Sophia Hernandez, Ogonna N. Nnamani Silva, Matthew Y.C. Lin, Edward H. Kim, Julie Ann Sosa, Andre R. Campbell, Patricia S. O'Sullivan, Sanziana A. Roman
Sun Sep 13, 2020 16:10
Publication date: Available online 12 September 2020Source: Pathology - Research and PracticeAuthor(s): Qichen Liu, Feng Lu, Zhong Chen
Sun Sep 13, 2020 15:59
Publication date: Available online 12 September 2020Source: Pathology - Research and PracticeAuthor(s): Xianyong Gui, Marietta Iacucci, Subrata Ghosh
Sun Sep 13, 2020 15:59
Publication date: Available online 12 September 2020Source: CortexAuthor(s): Bo-Yeong Won, Martha Forloines, Zhiheng Zhou, Joy J. Geng
Sun Sep 13, 2020 15:55
Publication date: Available online 12 September 2020Source: CortexAuthor(s): Terje B. Holmlund, Catherine Diaz-Asper, Brita Elvevåg
Sun Sep 13, 2020 15:55
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Jéssica Diniz Pereira, Jéssica Abdo Gonçalves Tosatti, Ricardo Simões, Marcelo Rizzatti Luizon, Karina Braga Gomes, Michelle Teodoro Alves
Sun Sep 13, 2020 15:30
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Yanting Li, Nan Li, Xiaojun Zhao, Bo Zhang, Lingling Yang, Jingjing Liu, Hunter Snooks, Changling Hu, Xueqin Ma
Sun Sep 13, 2020 15:30
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Bin Dai, Zi-Zhang Wang, Hui Zhang, Meng-Xiao Han, Guo-Xing Zhang, Jing-Wei Chen
Sun Sep 13, 2020 15:30
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Xionghua Sun, Xinjian Cui, Xihua Chen, Xiaogang Jiang
Sun Sep 13, 2020 15:30
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Rong Ma, Qian Xie, Yong Li, Zhuoping Chen, Mihong Ren, Hai Chen, Hongyan Li, Jinxiu Li, Jian Wang
Sun Sep 13, 2020 15:30
Publication date: Available online 12 September 2020Source: Journal of ProteomicsAuthor(s): Xiang Fang, Mei Lu, Zhengkun Xia, Chunlin Gao, Yan Cao, Ren Wang, Meiqiu Wang, Heyan Wu
Sun Sep 13, 2020 15:28
Publication date: Available online 12 September 2020Source: Journal of ProteomicsAuthor(s): Sergio Ciordia, Gloria Alvarez-Sola, María Rullán, Jesús M. Urman, Matías A. Ávila, Fernando J. Corrales
Sun Sep 13, 2020 15:28
Publication date: November 2020Source: Clinical Neurology and Neurosurgery, Volume 198Author(s): Damian Kocur, Piotr Paździora, Jan Baron, Adam Rudnik
Sun Sep 13, 2020 15:04
Publication date: November 2020Source: Clinical Neurology and Neurosurgery, Volume 198Author(s): Satrirat Jantasri, Somsak Tiamkao, Kittisak Sawanyawisuth
Sun Sep 13, 2020 15:04
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Youwei Pu, Zijing Liu, Cheng Zhong, Xuyu Zhang, Yixi Bao
Sun Sep 13, 2020 14:38
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Kangwei Wang, Zaixue Jiang, Xiaomei Lu, Yaozhong Zhang, Xu Yuan, Dong Luo, Zitian Lin, Yong Zuo, Qingming Luo
Sun Sep 13, 2020 14:38
Objectives: The objective of this study was to evaluate the sensitivity and reliability of one subjective (rating scale) and three objective (dual-task paradigm, pupillometry, and skin conductance response amplitude) measures of listening effort across multiple signal to noise ratios (SNRs). Design: Twenty adults with normal hearing attended two sessions and listened to sentences presented in quiet and in stationary noise at three different SNRs: 0, –3, and –5 dB. Listening effort was assessed...
Thu Sep 10, 2020 03:00
Objectives: Speech intelligibility in the presence of a competing talker (speech-on-speech; SoS) presents more difficulties for cochlear implant (CI) users compared with normal-hearing listeners. A recent study implied that these difficulties may be related to CI users’ low sensitivity to two fundamental voice cues, namely, the fundamental frequency (F0) and the vocal tract length (VTL) of the speaker. Because of the limited spectral resolution in the implant, important spectral cues carrying...
Thu Sep 10, 2020 03:00
Objective: The purpose of the present study was to investigate effective masking levels (EMLs) for bone conduction (BC) auditory brainstem response (ABR) testing in infants and adults. Early hearing detection and intervention programs aim to limit delays in identifying ear-specific type/degree of hearing loss in infants using the ABR. Ear-specific assessment poses challenges as sound delivered to one ear can travel across the skull and activate the contralateral cochlea. Wave V amplitude and latency...
Thu Sep 10, 2020 03:00
Individuals with acquired brain injuries (ABI) are in need of neurorehabilitation and neurorepair. Virtual anatomical interactivity (VAI) presents a digital game-like format in which ABI survivors with upper l...
Sat Sep 12, 2020 03:00
One of the most celebrated textbook examples of physiological adaptations to desert environments is the unique ability that desert mammals have to produce hyperosmotic urine. Commonly perceived as an adaptation mainly observed in small rodents, the extent to which urine concentrating ability has independently evolved in distinct lineages, including medium-sized and large desert mammals, has not previously been assessed using modern phylogenetic approaches. Here, we explicitly test the general hypothesis...
Sun Sep 13, 2020 03:00
Publication date: Available online 12 September 2020Source: Revista Española de Medicina Nuclear e Imagen MolecularAuthor(s): G Rabiller, N Cordoba, C Poch, P Silva Paulo, M Seijas, M. F Vazquez
Sun Sep 13, 2020 13:32
Publication date: Available online 12 September 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Elisabeth Goetze, Daniel G.E. Thiem, Matthias W. Gielisch, Peer W. Kämmerer
Sun Sep 13, 2020 13:32
Sat Sep 12, 2020 21:19
Publication date: Available online 12 September 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Cornelis G. Vos, Jean-Paul P.M. de Vries
Sun Sep 13, 2020 13:08
Publication date: Available online 12 September 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Jonothan J. Earnshaw
Sun Sep 13, 2020 13:08
Abstract BACKGROUND Persons with Down syndrome (DS) are presumed to be at high risk of severe CoVID‐19, due to immune dysregulation and often compromised cardiopulmonary function. Aim of the present study is to assess epidemiological and clinical characteristics of individuals with DS deceased in Italian hospitals with CoVID‐19. METHODS We used a nationwide database of 3,438 patients deceased with RT‐PCR‐confirmed SARS‐CoV‐2 infection in Italy (10.4% of all deaths with CoVID‐19 in the country...
Sat Sep 12, 2020 14:17
Amyloid deposits in the liver are recognized by their hematoxylin and eosin (H&E) findings, consisting of acellular eosinophilic deposits in various compartments of the liver parenchyma, including the stroma, vessels, and rarely the hepatocytes. H&E findings that suggest amyloid are then confirmed by Congo red stains and subtyped when clinically needed. Two cases are reported with sinusoidal deposits of acellular material that closely mimicked amyloid on H&E, but were Congo red negative....
Wed Sep 09, 2020 03:00
Identification of the primary site of cancer is essential for the treatment of patients with cancer. Numerous immunohistochemical markers have been developed to determine the differentiation of tumor cells and suggest possible primary sites, but markers of gastric and pancreatic adenocarcinomas are still lacking. Claudin-18 is a tight-junction protein uniquely expressed in gastric epithelial cells and has been shown to be expressed in gastric and pancreatic adenocarcinoma. Whether claudin-18 can...
Wed Sep 09, 2020 03:00
No abstract available
Wed Sep 09, 2020 03:00
Abstract figure legend Counterclockwise from top centre picture: August Krogh won the unopposed Nobel prize in Physiology or Medicine in 1920 for his three seminal papers, published the preceding year in The Journal of Physiology. These papers redefined the role of capillaries in supplying oxygen to skeletal muscle at rest and during exercise. His capillary recruitment theory was entirely novel and surmised that, in resting muscle, the vast majority of capillaries were constricted (closed, small...
Sat Sep 12, 2020 17:15
Key points Maternal shift work increases the risk of pregnancy complications, although its effects on progeny health after birth were not clear. We evaluated the impact of a simulated shift work protocol for one third, two thirds, or all of pregnancy on metabolic health of sheep progeny. Simulated shift work had no effect on growth, body size, body composition or glucose tolerance in pre‐pubertal or young adult progeny. Glucose stimulated insulin secretion was reduced in adult female progeny...
Sat Sep 12, 2020 16:24
Abstract Tocilizumab is an IL‐6 receptor antagonist with the ability to suppress the cytokine storm in critically ill patients infected with SARS‐CoV‐2. We evaluated patients treated with tocilizumab for a SARS‐CoV‐2 infection who were admitted between 3/13/20 and 4/16/20. This was a multi‐center study with data collected by chart review both retrospectively and concurrently. Parameters evaluated included age, sex, race, use of mechanical ventilation (MV), usage of steroids and vasopressors, inflammatory...
Sat Sep 12, 2020 17:15
Abstract Prolonged ischemia of tissues inevitably leads to their necrosis. This is especially relevant in the case of transplantation or replantation. In such situations, reperfusion in a timely manner might not be possible due to transportation times or other unforeseen complications. Therefore, a readily available and simple method to oxygenate the tissue and thus widen the time frame to reperfusion seems desirable. Here, we present the case of extracorporal perfusion of a latissimus dorsi (LD)...
Sat Sep 12, 2020 18:19
A gene cluster encoding a cryptic trans ‐acyl transferase polyketide synthase (PKS) was identified in the genomes of Burkholderia gladioli BCC0238 and BCC1622, both isolated from the lungs of cystic fibrosis patients. Bioinfomatics analyses indicated the PKS assembles a novel member of the glutarimide class of antibiotics, hitherto only isolated from Streptomyces species. Screening of a range of growth parameters enabled gladiostatin, the metabolic product of the PKS, to be identified. NMR...
Sat Sep 12, 2020 22:28
The invasion of cancer is brought about by continuous interaction of malignant cells with their surrounding tissue microenvironment. Investigating the remodeling of local extracellular matrix (ECM) by invading cells can therefore provide fundamental insights into the dynamics of cancer progression. In this paper, we use an active and untethered nanomechanical tool, realized as magnetically driven nanomotors, to locally probe a 3D tissue culture microenvironment. We made the surprising observation...
Sat Sep 12, 2020 21:29
The adsorption and electrooxidation of CO molecules at well‐defined Pt( hkl ) single crystal electrode surfaces is a key step towards addressing catalyst poisoning mechanisms in fuel cells. Herein, we employed in situ electrochemical shell‐isolated nanoparticle‐enhanced Raman spectroscopy (SHINERS) coupled with theoretical calculation to investigate CO electrooxidation on Pt( hkl ) surfaces in acidic solution. We successfully obtained the Raman signal of top and bridge site adsorbed CO* molecules...
Sat Sep 12, 2020 16:30
Porous graphene has shown promise as a new generation of selective membrane for sieving atoms, ions and molecules. However, the atomistic mechanisms of permeation through defects in the graphenic lattice are still unclear and remain unobserved in action, at the atomic level. Here, the direct observation of palladium atoms from a nanoparticle and passing through a defect in a single‐walled carbon nanotube one‐by‐one has been achieved with atomic resolution in real time, revealing key stages of the...
Sat Sep 12, 2020 15:29
Abstract The localizationist model, which focused on classical cortical areas such as Broca's and Wernicke's, can no longer explain how language processing works. Over recent years, several studies have revealed new language‐related cortical and subcortical areas, resulting in a transition from localizationist concepts to a hodotopical model. These studies have described language processing as an extensive and complex network of multiple interconnected cortical areas and subcortical pathways, differing...
Sat Sep 12, 2020 13:00
Abstract Background Process‐related measures have been proposed as quality metrics in head and neck cancer care. A recent single‐institution study identified four key metrics associated with increased survival. This study sought to validate the association of these quality metrics with survival in a multi‐institutional cohort. Methods Multicenter retrospective study of patients with oral cavity squamous cell (1/2005‐1/2015). Baseline patient and disease characteristics and compliance with...
Sat Sep 12, 2020 22:58
Abstract Background Oropharyngeal squamous cell carcinoma (OPSCC) epidemiology has not been examined previously in the nationwide Veterans Affairs (VA) population. Methods Joinpoint regression analysis was applied to OPSCC cases identified from VA administrative data from 2000 to 2012. Results We identified 12 125 OPSCC cases (incidence: 12.2 of 100 000 persons). OPSCC incidence declined between 2000 and 2006 (annual percent change [APC] = −4.27, P < .05), then increased between...
Sat Sep 12, 2020 22:23
Abstract Background Endoscopic endonasal approaches (EEAs) have been adopted as an alternative to standard transcranial approaches for olfactory groove meningiomas (OGMs). However, the relative cost‐effectiveness remains controversial. Methods Cost‐utility analysis from a societal perspective comparing EEA vs transcranial approaches for OGM was used in this study. Surgical treatment was modeled using decision analysis, and a Markov model was adopted over a 20‐year horizon. Parameters were...
Sat Sep 12, 2020 22:12
Objectives/Hypothesis We have found no study assessing the accuracy of caliper cranium measurements compared to computed tomography (CT) measurements of the head. The objective of this study was to assess the reliability of caliper measurements in comparison to CT measurements. Study Design Retrospective chart review. Methods This study includes all patients evaluated for head shape abnormality between 2010 and 2019 at a single academic medical center. Eighty‐nine patients who had CT...
Sat Sep 12, 2020 18:12
Chronic cough is a common complaint in the pediatric population and can have many different etiologies. We present a rare case of a tracheal lobular capillary hemangioma (LCH), also known as pyogenic granuloma, causing chronic cough in a child. In this case, the tracheal LCH was managed successfully with laser ablation. A review of the literature reveals only 2 other reported pediatric cases of tracheal LCH. Laryngoscope, 2020
Sat Sep 12, 2020 17:58
Objectives Parotid lymph node metastases are common in head and neck cutaneous squamous cell carcinoma (cSCCHN). Here we evaluate the diagnostic, prognostic, and therapeutic implications of intraglandular lymph node (IGLN) metastases in cSCCHN. Study Design Retrospective study in a tertiary referral university cancer institute. Methods We included patients with cSCCHN who underwent parotidectomy and neck dissection (ND), with or without synchronous resection of the skin primary, between...
Sat Sep 12, 2020 13:31
Abstract Background Bacille Calmette‐Guerin (BCG) adenitis is a common complication of post‐BCG vaccination. Awareness of this lesser known entity in fine‐needle aspiration (FNA) is important to prevent misdiagnosis. Aim This study described the clinical presentation, cytomorphological features and disease pattern in patients with BCG adenitis. Materials and methods We analyzed a series of 15 patients with BCG adenitis seen from July 2017 to July 2019. The detailed clinical and cytomorphology...
Sat Sep 12, 2020 16:04
Objectives To examine the association between cerebellar hemorrhage (CBH) size and location and preschool‐age neurodevelopment in very preterm neonates. Methods Preterm MRIs of 221 very preterm neonates (median GA 27.9) were manually segmented for CBH quantification and location. Neurodevelopmental assessments at chronological age 4.5 years included motor (MABC‐2), visuomotor integration (Beery VMI‐6), cognitive (WPPSI‐III), and behavioral (CBCL) outcomes. Multivariable linear regression models...
Sat Sep 12, 2020 21:20
Abstract Cervical cancer (CC) remains one of the leading causes of mortality of female cancers worldwide, with more than 90% of them are cervical squamous cell carcinoma (CSCC). ΔNp63α is the predominant isoform expressed in cervical epithelial tissues and exerts its anti‐tumor function in CSCC. In this study, we have identified 39 long noncoding RNAs as ΔNp63α targets in CSCC through RNA‐sequencing and chromatin immunoprecipitation‐sequencing, in which we further confirmed and focused on the two...
Sat Sep 12, 2020 17:59
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV2) pandemic has resulted in an urgent need to understand the pathophysiology of SARS‐CoV2 infection, to assist in the identification of treatment strategies. Viral tissue tropism is an active area of investigation, one approach to which is identification of virus within tissues by electron microscopy of post‐mortem and surgical specimens. Most diagnostic histopathologists have limited understanding of the ultrastructural features...
Sat Sep 12, 2020 17:05
Abstract Nonalcoholic fatty liver disease is a chronic condition involving steatosis, steatohepatitis and fibrosis, and its progression remains unclear. Although the tetraspanin TM4SF5 is involved in hepatic fibrosis and cancer, its role in nonalcoholic steatohepatitis (NASH) progression is unknown. We investigated the contribution of TM4SF5 to liver pathology using transgenic and knockout mice, diet‐ or drug‐treated mice, in vitro primary cells, and in human tissue. TM4SF5‐overexpressing mice exhibited...
Sat Sep 12, 2020 16:59
Abstract Skin grafting is a surgical method of cutaneous reconstruction, which provides volumetric replacement in wounds unable to heal by primary intention. Clinically, full‐thickness skin grafts (FTSG) are placed in aesthetically sensitive and mechanically demanding areas such as the hands, face, and neck. Complete or partial graft failure is the primary complication associated with this surgical procedure. Strategies aimed at improving the rate of skin graft integration will reduce the incidence...
Sat Sep 12, 2020 16:55
Gene duplication is an important source of evolutionary innovation, but the adaptive division-of-labor between duplicates can be opposed by ongoing gene conversion between them. Here we document a tandem duplication of Na+,K+-ATPase subunit 1 (ATP1A1) shared by frogs in the genus Leptodactylus, a group of species that feeds on toxic toads. One ATP1A1 paralog evolved resistance to toad toxins while the other paralog retained ancestral susceptibility. We show that the two Leptodactylus paralogs are...
Sat Sep 12, 2020 03:00
A bacterium's fitness relative to its competitors, both in the presence and absence of antibiotics, plays a key role in its ecological success and clinical impact. In this study, we examine whether tetracycline-resistant mutants are less fit in the absence of the drug than their sensitive parents, and whether the fitness cost of resistance is constant or variable across independently derived lines. Tetracycline-resistant lines suffered, on average, a reduction in fitness of almost 8%. There was substantial...
Sat Sep 12, 2020 03:00
In mammals, the placenta mediates maternal-fetal nutrient and waste exchange and provides immunomodulatory actions that facilitate maternal-fetal tolerance. The placenta is highly diversified among mammalian species, yet the molecular mechanisms that distinguish the placenta of human from other mammals are not fully understood. Using an interspecies transcriptomic comparison of human, macaque, and mouse term placentae, we identified hundreds of genes with lineage-specific expression - including dozens...
Sat Sep 12, 2020 03:00
Recombination has been shown to contribute to HIV-1 evolution in vivo, but the underlying dynamics are extremely complex, depending on the nature of the fitness landscapes and of epistatic interactions. A less well-studied determinant of recombinant evolution is the mode of virus transmission in the cell population. HIV-1 can spread by free virus transmission, resulting largely in singly infected cells, and also by direct cell-to-cell transmission, resulting in the simultaneous infection of cells...
Sat Sep 12, 2020 03:00
Epithelioid malignant peripheral nerve sheath tumor arising in schwannoma. Rare Tumors. 2020;12:2036361320950862 Authors: Heatley N, Kolson Kokohaare E, Strauss DC, Hallin M, Jones RL, Fisher C, Thway K Abstract Epithelioid malignant peripheral nerve sheath tumor (EMPNST, malignant epithelioid schwannoma) is a rare variant of malignant peripheral nerve sheath tumor that has morphologic and immunophenotypic overlap with a variety of epithelioid...
Sun Sep 13, 2020 04:06
Abstract Parkinson’s disease is a neurological disorder that causes partial or complete loss of motor reflexes and speech and affects thinking, behavior, and other vital functions affecting the nervous system. Parkinson’s disease causes impaired speech and motor abilities (writing, balance, etc.) in about 90% of patients and is often seen in older people. Some signs (deterioration of vocal cords) in medical voice recordings from Parkinson’s patients are used to diagnose this disease....
Sun Sep 13, 2020 03:00
Abstract Introduction Hyperparathyroidism (HPT) is associated with mortality and cardiovascular disease (CVD) in dialysis patients. However, its mechanism is still unclear. It is suspected that parathyroid hormone (PTH) is associated with the renin–angiotensin–aldosterone system (RAAS) as a possible mechanism. Thus, we examined their hormonal interaction in hemodialysis patients with secondary HPT. ...
Sat Sep 12, 2020 03:00
278 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2020/09/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sun Sep 13, 2020 02:28
177 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2020/09/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sun Sep 13, 2020 02:21
Abstract The aim of this study is to evaluate fertility preservation (FP) popularization in China among female cancer patients in terms of awareness of fertility, knowledge about FP, and attitudes toward FP. A questionnaire-based survey was conducted among female cancer patients in Tongji Hospital in China from March 2019 to July 2019. The 29 fertility-related issues, which were presented in either five-point Likert scales or “yes or no”, in this questionnaire consisted of demographic...
Sat Sep 12, 2020 03:00
642 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: upper respiratory tract infection These pubmed results were generated on 2020/09/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sun Sep 13, 2020 01:46
Medulloblastoma is an embryonal neuroepithelial tumor that affects mainly childhood and more rarely adults. Medulloblastoma occurring as multiple nodules at diagnosis is a rare and tricky presentation. Here, we describe the case of a previously healthy 47-year-old woman with multiple posterior fossa cerebellar tumors. Histological, immunohistochemical, and molecular analyses were performed to best characterize the two excised lesions. The histopathological analysis revealed different variants of...
Sat Sep 12, 2020 13:05
Pain is the most common symptom in patients with rheumatoid arthritis (RA). Although in recent years, through the implementation of targeted treatment and the introduction of disease-modifying antirheumatic drugs (DMARDs), the treatment of RA patients has made a significant progress, a large proportion of patients still feel pain. Finding appropriate treatment to alleviate the pain is very important for RA patients. Current research showed that, in addition to inflammation, RA pain involves peripheral...
Sat Sep 12, 2020 19:35
Abstract The purpose of this study was to prospectively evaluate the distribution of PSMA-targeted, PET-avid lesions in prostate cancer (PCa) patients with biochemical recurrence in a Chinese cohort. The relationships between PSA levels, disease-free time after prostatectomy, and 68Ga-PSMA-11 PET/computed tomography (CT) findings were investigated. Inclusion criteria included histopathologically proven prostate adenocarcinoma, two consecutive PSA levels > 0.20 ng/mL, and...
Sat Sep 12, 2020 03:00
High-risk organisations (HRO), including aviation, undergo formal communication training, with emphasis on safety-critical moments. Such training is not widespread or mandatory in healthcare, and while there are many differences both share the ‘human element’ with circumstances leading to an increased risk of harm. A typical operating theatre consists of an operating surgeon, and an assisting surgeon, roles that may change throughout the course of a procedure. Similarly, a training aircraft or multi-crew...
Sat Sep 12, 2020 03:00
This case report highlights an ocular complication associated with platelet-rich plasma temporomandibular joint injections. This pioneering treatment can risk irreversible visual loss. This case highlights the importance of an experienced technique, in depth understanding of facial anatomy, and promptly recognising and referring the patient to a specialist to manage the complication should it arise.
Sat Sep 12, 2020 03:00
Head and neck surgery has made efficient use of dual-team operating, making it standard practice. The raising and preparation of a reconstructive free flap to coincide with a neck dissection and resection of a tumour has reduced patient morbidity with the benefit of reduced operating time. However, there is an inherent issue with two-team operations: the difficulty of timing the raising of a complex composite flap to coincide with completed preparation of the recipient site. There are serious failures...
Sat Sep 12, 2020 03:00
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