Pemphigus encompasses a group of chronic autoimmune blistering diseases of the skin and/or mucosa. Rituximab (RTX) has shown promising efficacy for the treatment of pemphigus in the past decade. Considering potential cardiac side effects, this study was conducted to assess the effects of RTX on electrocardiogram (ECG) parameters in pemphigus patients. This observational cross‐sectional study was conducted in 80 consecutive patients with pemphigus who were eligible for RTX infusion. The patients'...
Fri Sep 11, 2020 19:38
Abstract Bromoderma is a rare hypersensitivity reaction caused by bromide intake. It was relatively frequent in the early years of the previous century because of the common use of bromide‐containing solutions in pediatricsdue to their antispasmodic, expectorant, sedative, and anticonvulsant effects. Although recently prohibited in many countries, bromides are still used as an adjuvant anticonvulsant drug and still present in some over the counter antispasmodics and analgesics. Bromoderma usually...
Fri Sep 11, 2020 19:28
Abstract The lips are considered of great importance for the perception of beauty and thereis still a lacuna in the attempt to successfully re‐pigment resistant areas of vitiligo especially the lips.Notechnique evolved so far ensures 100% pigmentation with a good cosmetic appearance. To study the efficacy and cosmetic outcome following primary excision and closure in the management of lip vitiligo and assessing postoperative morbidity using the created Surgical Site Morbidity Score (SSMS). Twenty‐five...
Fri Sep 11, 2020 17:05
Relationship between the Levels of mRNA Expression for Protein Phosphatase 1B and Proteins Involved in Cytoskeleton Remodeling in Squamous Cell Carcinoma of the Larynx and Hypopharynx. Bull Exp Biol Med. 2020 Sep 11;: Authors: Kakurina GV, Kolegova ES, Shashova EE, Velikaya VV, Startseva ZA, Cheremisina OV, Choinzonov EL, Kondakova IV Abstract We analyzed the expression of genes encoding proteins involved in cytoskeleton remodeling (RND3, SNAI1,...
Sat Sep 12, 2020 13:14
Long noncoding RNAs in head and neck squamous cell carcinoma: biological functions and mechanisms. Mol Biol Rep. 2020 Sep 10;: Authors: Zhao J, Liu D, Yang H, Yu S, He H Abstract Head and neck squamous cell carcinoma (HNSCC) is the primary malignant tumor of the oral cavity, larynx, nasopharynx, esophagus and tongue. Although several novel therapeutic methods for HNSCC have been developed, the final therapeutic effect on the patient is still...
Sat Sep 12, 2020 13:14
Minocycline-induced black thyroid with black pigmentation of the thyroid cartilage, cricoid cartilage, and trachea found during reconstructive surgery for hypopharyngeal cancer. Auris Nasus Larynx. 2020 Sep 07;: Authors: Kondo T, Nakatsugawa M, Hirai Y, Takeda A, Kikawada N, Aihara Y, Chiba Y, Okimura A, Hirano H, Ogawa Y, Tsukahara K Abstract Black thyroid is characterized by a rare pigment change observed almost exclusively in patients taking...
Sat Sep 12, 2020 13:14
Laryngopharyngeal Reflux Alters Macrophages Polarization in HPV-Negative Squamous Cell Carcinoma of Larynx in Males. Clin Exp Otorhinolaryngol. 2020 Sep 11;: Authors: Zabolotnyi D, Kizim Y, Zabolotna D, Sulaieva O, Kizim V Abstract Objectives: Among various cells of tumor immune microenvironment (TIME) macrophages have been shown to play a pivotal role in the prognosis of many malignancies including laryngeal squamous cell carcinoma (LSCC)....
Sat Sep 12, 2020 13:14
Multicentric Reticulohistiocytosis Exhibiting Positive HLA-B*07 and HLA-B*08: A Case Report. Medicina (Kaunas). 2020 Sep 08;56(9): Authors: Rezuș E, Burlui MA, Cardoneanu A, Haba D, Danciu M, Cozma RS, Rezuș C Abstract Multicentric reticulohistiocytosis (MRH) is a rare cause of destructive inflammatory arthritis involving both small, as well as larger joints. We report the case of a 40-year-old Caucasian female with a family history of neoplasia...
Sat Sep 12, 2020 13:14
Related Articles COVID-19 Pandemic and its Impact on Craniofacial Surgery. J Craniofac Surg. 2020 Sep;31(6):e620-e622 Authors: Andrews BT, Garg R, Przylecki W, Habal M Abstract In late 2019, a novel coronavirus strain, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), also known as coronavirus disease 2019 (COVID-19), triggered a global pandemic as the virus spread from the Wuhan Province, China, across all continents. Although...
Sat Sep 12, 2020 13:14
Related Articles Could the infiltration of the thyroarytenoid muscle define the pT2 glottic carcinoma? Head Neck. 2019 10;41(10):3639-3646 Authors: Lionello M, Bertolin A, Nardello E, Giacomelli L, Canal F, Rizzotto G, Marioni G, Lucioni M Abstract BACKGROUND: The involvement of the thyroarytenoid (TA) muscle by glottic cancer may be related to an impaired vocal cord mobility, which is classified as cT2 disease. The primary endpoint was to...
Sat Sep 12, 2020 13:14
Related Articles Effects of Age on Voice Onset Time and Variability in Children with Repaired Cleft Palate. Folia Phoniatr Logop. 2020;72(1):36-42 Authors: Bae Y Abstract OBJECTIVE: To examine the effect of age on voice onset time (VOT) and VOT variability in children with repaired cleft palate. METHODS: Twenty-two children with repaired cleft palate were allocated into two age groups: younger children (YC: n = 13) and older children...
Sat Sep 12, 2020 13:14
An Insight on Molecular Mechanisms & Novel Therapeutic Approaches in Epileptogenesis. CNS Neurol Disord Drug Targets. 2020 Sep 10;: Authors: Singh S, Singh TG, Rehni AK Abstract Epilepsy is a second most common neurological disease with abnormal neural activity involving activation of various intracellular signalling transduction mechanisms. The molecular and system biology mechanisms responsible for epileptogenesis are not well defined...
Sat Sep 12, 2020 13:13
Publication date: September–October 2020Source: Journal of Communication Disorders, Volume 87Author(s):
Sat Sep 12, 2020 13:13
Vestibular mapping in patients with unilateral peripheral-vestibular deficits. Neurology. 2020 Sep 10;: Authors: Tarnutzer AA, Bockisch CJ, Buffone E, Weber KP Abstract OBJECTIVE: To test the hypothesis that patterns of semicircular canal (SCC) and otolith impairment in unilateral vestibular-loss depend on the underlying disorders, we analyzed peripheral-vestibular function of all five vestibular sensors. METHODS: Retrospective case-series....
Sat Sep 12, 2020 13:08
35 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2020/09/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Sep 12, 2020 13:08
Amino acids in the Tagish meteorite. Proc Natl Acad Sci U S A. 2020 Sep 10;: Authors: Bada JL PMID: 32913062 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 13:05
Reply to Bada: Acidity and fluid composition on the Tagish Lake parent body. Proc Natl Acad Sci U S A. 2020 Sep 10;: Authors: White LF, Tait KT, Langelier B, Lymer EA, Černok A, Kizovski TV, Ma C, Tschauner O, Nicklin RI PMID: 32913061 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 13:05
Tuning the Baird aromatic triplet-state energy of cyclooctatetraene to maximize the self-healing mechanism in organic fluorophores. Proc Natl Acad Sci U S A. 2020 Sep 10;: Authors: Pati AK, El Bakouri O, Jockusch S, Zhou Z, Altman RB, Fitzgerald GA, Asher WB, Terry DS, Borgia A, Holsey MD, Batchelder JE, Abeywickrama C, Huddle B, Rufa D, Javitch JA, Ottosson H, Blanchard SC Abstract Bright, photostable, and nontoxic fluorescent contrast agents...
Sat Sep 12, 2020 13:05
Multiheme hydroxylamine oxidoreductases produce NO during ammonia oxidation in methanotrophs. Proc Natl Acad Sci U S A. 2020 Sep 10;: Authors: Versantvoort W, Pol A, Jetten MSM, van Niftrik L, Reimann J, Kartal B, Op den Camp HJM Abstract Aerobic and nitrite-dependent methanotrophs make a living from oxidizing methane via methanol to carbon dioxide. In addition, these microorganisms cometabolize ammonia due to its structural similarities to...
Sat Sep 12, 2020 13:05
Fold class and evolutionary mobility of protein modules. Proc Natl Acad Sci U S A. 2020 Sep 10;: Authors: Patthy L PMID: 32913058 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 13:05
Spatial heterogeneity can lead to substantial local variations in COVID-19 timing and severity. Proc Natl Acad Sci U S A. 2020 Sep 10;: Authors: Thomas LJ, Huang P, Yin F, Luo XI, Almquist ZW, Hipp JR, Butts CT Abstract Standard epidemiological models for COVID-19 employ variants of compartment (SIR or susceptible-infectious-recovered) models at local scales, implicitly assuming spatially uniform local mixing. Here, we examine the effect of...
Sat Sep 12, 2020 13:05
Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane. Proc Natl Acad Sci U S A. 2020 Sep 10;: Authors: Van QN, López CA, Tonelli M, Taylor T, Niu B, Stanley CB, Bhowmik D, Tran TH, Frank PH, Messing S, Alexander P, Scott D, Ye X, Drew M, Chertov O, Lösche M, Ramanathan A, Gross ML, Hengartner NW, Westler WM, Markley JL, Simanshu DK, Nissley DV, Gillette WK, Esposito D, McCormick F, Gnanakaran S, Heinrich F, Stephen...
Sat Sep 12, 2020 13:05
Mechanical design of the highly porous cuttlebone: A bioceramic hard buoyancy tank for cuttlefish. Proc Natl Acad Sci U S A. 2020 Sep 10;: Authors: Yang T, Jia Z, Chen H, Deng Z, Liu W, Chen L, Li L Abstract Cuttlefish, a unique group of marine mollusks, produces an internal biomineralized shell, known as cuttlebone, which is an ultra-lightweight cellular structure (porosity, ∼93 vol%) used as the animal's hard buoyancy tank. Although cuttlebone...
Sat Sep 12, 2020 13:05
General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM. Proc Natl Acad Sci U S A. 2020 Sep 10;: Authors: Wang F, Liu Y, Yu Z, Li S, Feng S, Cheng Y, Agard DA Abstract Affinity grids have great potential to facilitate rapid preparation of even quite impure samples in single-particle cryo-electron microscopy (EM). Yet despite the promising advances of affinity grids over the past decades, no single strategy...
Sat Sep 12, 2020 13:05
Suboptimal SARS-CoV-2-specific CD8+ T cell response associated with the prominent HLA-A*02:01 phenotype. Proc Natl Acad Sci U S A. 2020 Sep 10;: Authors: Habel JR, Nguyen THO, van de Sandt CE, Juno JA, Chaurasia P, Wragg K, Koutsakos M, Hensen L, Jia X, Chua B, Zhang W, Tan HX, Flanagan KL, Doolan DL, Torresi J, Chen W, Wakim LM, Cheng AC, Doherty PC, Petersen J, Rossjohn J, Wheatley AK, Kent SJ, Rowntree LC, Kedzierska K Abstract An improved...
Sat Sep 12, 2020 13:05
Modulation of acyl-carnitines, the broad mechanism behind Wolbachia-mediated inhibition of medically important flaviviruses in Aedes aegypti. Proc Natl Acad Sci U S A. 2020 Sep 10;: Authors: Manokaran G, Flores HA, Dickson CT, Narayana VK, Kanojia K, Dayalan S, Tull D, McConville MJ, Mackenzie JM, Simmons CP Abstract Wolbachia-infected mosquitoes are refractory to flavivirus infections, but the role of lipids in Wolbachia-mediated virus blocking...
Sat Sep 12, 2020 13:05
Early programming of CD8+ T cell response by the orphan nuclear receptor NR4A3. Proc Natl Acad Sci U S A. 2020 Sep 10;: Authors: Odagiu L, Boulet S, Maurice De Sousa D, Daudelin JF, Nicolas S, Labrecque N Abstract Enhancing long-term persistence while simultaneously potentiating the effector response of CD8+ T cells has been a long-standing goal in immunology to produce better vaccines and adoptive cell therapy products. NR4A3 is a transcription...
Sat Sep 12, 2020 13:05
Near-zero-index media as electromagnetic ideal fluids. Proc Natl Acad Sci U S A. 2020 Sep 10;: Authors: Liberal I, Lobet M, Li Y, Engheta N Abstract Near-zero-index (NZI) supercoupling, the transmission of electromagnetic waves inside a waveguide irrespective of its shape, is a counterintuitive wave effect that finds applications in optical interconnects and engineering light-matter interactions. However, there is a limited knowledge on the...
Sat Sep 12, 2020 13:05
Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas. Proc Natl Acad Sci U S A. 2020 Sep 10;: Authors: Esteban-Burgos L, Wang H, Nieto P, Zheng J, Blanco-Aparicio C, Varela C, Gómez-López G, Fernández-García F, Sanclemente M, Guerra C, Drosten M, Galán J, Caleiras E, Martínez-Torrecuadrada J, Fajas L, Peng SB, Santamaría D, Musteanu M, Barbacid M Abstract KRAS mutant lung adenocarcinomas...
Sat Sep 12, 2020 13:05
Robert May, 1936-2020: A man for all disciplines. Proc Natl Acad Sci U S A. 2020 Sep 10;: Authors: Galvani A, Hastings A, Levin SA, Singer BH PMID: 32913048 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 13:05
FBXW7γ is a tumor-suppressive and prognosis-related FBXW7 transcript isoform in ovarian serous cystadenocarcinoma. Future Oncol. 2020 Sep;16(25):1921-1930 Authors: Xu Z, Zhuang L, Wang X, Li Q, Sang Y, Xu J Abstract Aim: To explore FBXW7 protein-coding transcript isoform (α, β and γ) expression, their functions and prognostic value in ovarian serous cystadenocarcinoma (OSC). Materials & methods: FBXW7 transcript data were collected from...
Sat Sep 12, 2020 13:04
Mechanisms Targeting the Unfolded Protein Response in Asthma. Am J Respir Cell Mol Biol. 2020 Sep 11;: Authors: Dastghaib S, Kumar PS, Aftabi S, Damera G, Dalvand A, Sepanjnia A, Kiumarsi M, Aghanoori MR, Sohal SS, Ande SR, Alizadeh J, Mokarram P, Ghavami S, Sharma P, Zeki AA Abstract Lung cells are constantly exposed to various internal and external stressors that disrupt protein homeostasis. To cope with these stimuli, cells evoke a highly...
Sat Sep 12, 2020 13:04
Use of telehealth platforms for delivering supportive care to adults with primary brain tumors and their family caregivers: A systematic review. Psychooncology. 2020 Sep 11;: Authors: Ownsworth T, Chan RJ, Jones S, Robertson J, Pinkham MB Abstract OBJECTIVE: Telehealth platforms have potential utility for providing remote access to supportive care to people with brain tumor. This systematic review aimed to evaluate the feasibility, acceptability...
Sat Sep 12, 2020 13:04
Next-generation humanized patient-derived xenograft mouse model for pre-clinical antibody studies in neuroblastoma. Cancer Immunol Immunother. 2020 Sep 11;: Authors: Nguyen R, Patel AG, Griffiths LM, Dapper J, Stewart EA, Houston J, Johnson M, Akers WJ, Furman WL, Dyer MA Abstract Faithful tumor mouse models are fundamental research tools to advance the field of immuno-oncology (IO). This is particularly relevant in diseases with low incidence,...
Sat Sep 12, 2020 13:04
Influence of tissue fixation on depth-resolved birefringence of oral cavity tissue samples. J Biomed Opt. 2020 Sep;25(9): Authors: Karnowski K, Li Q, Poudyal A, Villiger M, Farah CS, Sampson DD Abstract SIGNIFICANCE: To advance our understanding of the contrast observed when imaging with polarization-sensitive optical coherence tomography (PS-OCT) and its correlation with oral cancerous pathologies, a detailed comparison with histology provided...
Sat Sep 12, 2020 13:04
DNA Methylation as a Potential Molecular Mechanism in X-Linked Dystonia-Parkinsonism. Mov Disord. 2020 Sep 10;: Authors: Krause C, Schaake S, Grütz K, Sievert H, Reyes CJ, König IR, Laabs BH, Jamora RD, Rosales RL, Diesta CCE, Pozojevic J, Gemoll T, Westenberger A, Kaiser FJ, Klein C, Kirchner H Abstract BACKGROUND: X-linked dystonia-parkinsonism is a neurodegenerative movement disorder. The underlying molecular basis has still not been completely...
Sat Sep 12, 2020 13:04
Does location matter? Characterisation of the anatomic locations, molecular profiles, and clinical features of gliomas. Neurol Neurochir Pol. 2020 Sep 11;: Authors: Mackintosh C, Butterfield R, Zhang N, Lorence J, Zlomanczuk P, Bendok B, Zimmerman RS, Swanson K, Porter A, Mrugala MM Abstract BACKGROUND: Neuroanatomic locations of gliomas may influence clinical presentations, molecular profiles, and patients' prognoses. METHODS: We...
Sat Sep 12, 2020 13:04
Brief collaborative care intervention to reduce perceived unmet needs in highly distressed breast cancer patients: randomized controlled trial. Jpn J Clin Oncol. 2020 Sep 11;: Authors: Akechi T, Momino K, Katsuki F, Yamashita H, Sugiura H, Yoshimoto N, Wanifuchi-Endo Y, Toyama T Abstract OBJECTIVES: Our newly developed brief collaborative care intervention program has been suggested to be effective in reducing breast cancer patients' unmet...
Sat Sep 12, 2020 13:04
Molecular Rules Underpinning Enhanced Affinity Binding of Human T Cell Receptors Engineered for Immunotherapy. Mol Ther Oncolytics. 2020 Sep 25;18:443-456 Authors: Crean RM, MacLachlan BJ, Madura F, Whalley T, Rizkallah PJ, Holland CJ, McMurran C, Harper S, Godkin A, Sewell AK, Pudney CR, van der Kamp MW, Cole DK Abstract Immuno-oncology approaches that utilize T cell receptors (TCRs) are becoming highly attractive because of their potential...
Sat Sep 12, 2020 13:04
Membrane disruption, but not metabolic rewiring, is the key mechanism of anticancer-action of FASN-inhibitors: a multi-omics analysis in ovarian cancer. Sci Rep. 2020 Sep 10;10(1):14877 Authors: Grunt TW, Slany A, Semkova M, Colomer R, López-Rodríguez ML, Wuczkowski M, Wagner R, Gerner C, Stübiger G Abstract Fatty-acid(FA)-synthase(FASN) is a druggable lipogenic oncoprotein whose blockade causes metabolic disruption. Whether drug-induced metabolic...
Sat Sep 12, 2020 13:04
Minimal main pancreatic duct dilatation in small branch duct intraductal papillary mucinous neoplasms associated with high-grade dysplasia or invasive carcinoma. HPB (Oxford). 2020 Sep 07;: Authors: Amini N, Rezaee N, Habib JR, Blair A, Beckman RM, Manos L, Cameron JL, Hruban RH, Weiss MJ, Fishman EK, Zaheer A, Lafaro KJ, Burkhart RA, O'Broin Lennon AM, Burns WR, He J, Wolfgang CL Abstract BACKGROUND: The aim of this study was to determine...
Sat Sep 12, 2020 13:04
Patient Selection for Hyperthermic Intraperitoneal Chemotherapy in Patients With Colorectal Cancer: Consensus on Decision Making Among International Experts. Clin Colorectal Cancer. 2020 Jul 15;: Authors: Steffen T, Janina E, Lana B, Markus G, Olivier G, Diane G, Ignace H, Yan L, Brandon M, David M, Pompiliu P, Claudio Q, Beate R, Paul S, Yutaka Y, Martin PP Abstract BACKGROUND: Colorectal cancer (CRC) treatment for patients with peritoneal...
Sat Sep 12, 2020 13:04
Management of early breast cancer in patients bearing germline BRCA mutations. Semin Oncol. 2020 Aug 18;: Authors: t'Kint de Roodenbeke MD, Pondé N, Buisseret L, Piccart M Abstract Women diagnosed with breast cancers (BCs) that harbor BRCA1/2 mutations have an increased lifetime risk of a second BC and ovarian cancer. They may benefit from risk-reducing surgical strategies such as mastectomy and salpingo-oophorectomy. In cases of triple negative...
Sat Sep 12, 2020 13:04
Treatment of closed subtalar joint dislocation: A case report and literature review. Chin J Traumatol. 2020 Aug 27;: Authors: Wang HY, Wang BB, Huang M, Wu XT Abstract Subtalar dislocation is defined as a separation of the talocalcaneal and talonavicular articulations, commonly caused by high-energy mechanisms, which include falls from height, motor vehicle crashes, and twisting leg injuries. The dislocations are divided into medial, lateral,...
Sat Sep 12, 2020 13:04
Single-institution cross-sectional study to evaluate need for information and need for referral to psychooncology care in association with depression in brain tumor patients and their family caregivers. BMC Psychol. 2020 Sep 10;8(1):96 Authors: Reinert C, Gerken M, Rathberger K, Krueger K, Klinkhammer-Schalke M, Lindberg-Scharf P, Koelbl O, Proescholdt MA, Riemenschneider MJ, Pukrop T, Bumes E, Hutterer M, Hau P Abstract BACKGROUND: The prognosis...
Sat Sep 12, 2020 13:04
Insulin Resistance and Endometrial Cancer: Emerging Role for microRNA. Cancers (Basel). 2020 Sep 08;12(9): Authors: Sidorkiewicz I, Jóźwik M, Niemira M, Krętowski A Abstract Endometrial cancer (EC) remains one of the most common cancers of the female reproductive system. Epidemiological and clinical data implicate insulin resistance (IR) and its accompanying hyperinsulinemia as key factors in the development of EC. MicroRNAs (miRNAs) are short...
Sat Sep 12, 2020 13:04
Is There a Role for Immunotherapy in Prostate Cancer? Cells. 2020 Sep 08;9(9): Authors: Rizzo A, Mollica V, Cimadamore A, Santoni M, Scarpelli M, Giunchi F, Cheng L, Lopez-Beltran A, Fiorentino M, Montironi R, Massari F Abstract In the last decade, immunotherapy has revolutionized the treatment landscape of several hematological and solid malignancies, reporting unprecedented response rates. Unfortunately, this is not the case for metastatic...
Sat Sep 12, 2020 13:04
Related Articles The current state of randomized clinical trial evidence for prostate brachytherapy. Urol Oncol. 2019 09;37(9):599-610 Authors: Dess RT, Soni PD, Jackson WC, Berlin A, Cox BW, Jolly S, Efstathiou JA, Feng FY, Kishan AU, Stish BJ, Pisansky TM, Spratt DE Abstract Interstitial brachytherapy is one of several curative therapeutic options for the treatment of localized prostate cancer. In this review, we summarize all available randomized...
Sat Sep 12, 2020 13:04
134 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: head and neck These pubmed results were generated on 2020/09/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Sep 12, 2020 13:03
Publication date: Available online 12 September 2020Source: Behavioural Brain ResearchAuthor(s): Gene M. Heyman
Sat Sep 12, 2020 12:59
Publication date: Available online 11 September 2020Source: Behavioural Brain ResearchAuthor(s): Jesse J. Winters, Larry W. Hardy, Jenna M. Sullivan, Noel A. Powell, Mohammed Qutaish, Surabhi Nair, Jack Heimann, Ali Ghayoor, Ildiko Polyak, Lauren Chaby, Elizabeth Rodriguez, Dima Chaar, Jon Oscherwitz, Israel Liberzon
Sat Sep 12, 2020 12:59
Abstract ObjectiveTo examine the interrelationships among resilience, self‐esteem, and depressive symptoms and determine whether resilience was a factor associated with quality of life for Hong Kong Chinese children with cancer.MethodsWe used a cross‐sectional study design. Participants were 138 Hong Kong Chinese children (aged 7–14 years) who were admitted to the pediatric oncology units of an acute public hospital. The resilience, depressive symptoms, self‐esteem, and quality of life of participating...
Fri Sep 11, 2020 20:08
Abstract Objective Given the reported increased rates of physical morbidity and higher mortality rates among people with severe mental illness (SMI) (schizophrenia and severe mood disorders), with a life expectancy shorter of 15‐20 years with respect to the general population, the aim of this paper was to call attention to the problem of cancer in SMI. Methods We conducted a narrative review of the most significant papers published in the areas of cancer screening, incidence, mortality...
Fri Sep 11, 2020 17:05
Abstract ObjectiveTelehealth platforms have potential utility for providing remote access to supportive care to people with brain tumor. This systematic review aimed to evaluate the feasibility, acceptability and efficacy of delivering supportive care via telehealth platforms to adults with primary brain tumor and family caregivers.MethodsA systematic search of PsycINFO, MEDLINE, CINAHL, Embase, Scopus and Cochrane Library was conducted from 1980 to June 1st 2020 to identify eligible studies. Methodological...
Fri Sep 11, 2020 16:13
AbstractCancer is the second leading cause of death globally, approximately 70% of deaths from cancer occur in low‐ and middle‐income countries.1 About 1.3 million new cancer cases and 666,000 cancer deaths were estimated to have occurred in 2018 in Latin America and the Caribbean. Cancer is also the leading cause of death of Latinos in the U.S., accounting for approximately 42,700 deaths/year in the U.S. Latino population.2This article is protected by copyright. All rights reserved.This article...
Fri Sep 11, 2020 14:33
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Fri Sep 11, 2020 15:38
Many ideas about the evolution of specialization rely on trade-offs--an inability for one organism to express maximal performance in two or more environments. However, optimal foraging theory suggests that populations can evolve specialization on a superior resource without explicit trade-offs. Classical results in population genetics show that the process of adaptation can be biased toward further improvement in already productive environments, potentially widening the gap between superior and inferior...
Sat Sep 12, 2020 03:00
Abstract Closely related species with parapatric elevational ranges are ubiquitous in tropical mountains worldwide. The gradient speciation hypothesis proposes that these series are the result of in situ ecological speciation driven by divergent selection across elevation. Direct tests of this scenario have been hampered by the difficulty inferring the geographic arrangement of populations at the time of divergence. In cichlids, sticklebacks, and Timema stick insects, support for ecological speciation...
Fri Sep 11, 2020 11:29
Abstract Oral squamous cell carcinoma (OSCC) is a common epithelial malignancy of the oral cavity. Nodal and Cripto‐1 (CR‐1) are important developmental morphogens expressed in several adult cancers and are associated with disease progression. Whether Nodal and CR‐1 are simultaneously expressed in the same tumor and how this affects cancer biology is unclear. We investigate the expression and potential role of both Nodal and CR‐1 in human OSCC. Immunohistochemistry results show that that Nodal and...
Fri Sep 11, 2020 11:29
Abstract Mild clinical phenotypes of ataxia‐telangiectasia (variant A‐T) are associated with biallelic ATM variants resulting in residual function of the ATM kinase. At least one regulatory, missense, or leaky splice site mutation resulting in expression of ATM with low level kinase activity was identified in subjects with variant A‐T. Studies on the pathogenicity of the germline splicing ATM variant c.1066‐6T>G have provided conflicting results. Using whole‐exome sequencing, we identified two...
Fri Sep 11, 2020 20:48
We set out to determine the incidence of lost surgical needles, and then to test what size of needles are reliably detected on intra‐operative imaging. Our results suggest the risks associated with searching for small microneedles may outweigh the potential benefits. Abstract Background Unintentional retention of foreign bodies in surgery is uncommon but potentially serious. Published data regarding the consequence of retained surgical needles is sparse. We aimed to characterize lost...
Fri Sep 11, 2020 22:56
This study compares 663 patients undergoing closed reduction of paediatric forearm fractures in the emergency department under sedation to those performed in the operating theatre under general anaesthetic. We found comparable results between the two groups in regards to both re‐intervention rates and adverse events. Abstract Background Nitrous oxide with intranasal fentanyl is safe and effective in performing closed reduction of paediatric forearm fractures; however, the difference...
Fri Sep 11, 2020 22:55
Key points Rodent studies suggest muscle fibre type‐specific insulin response in the recovery from exercise. The current study investigates muscle fibre type‐specific insulin action in the recovery from exercise in healthy subjects. In type I and type II muscle fibres, key proteins in glucose metabolism are similarly regulated by insulin during recovery from exercise. Our findings imply that both type I and type II muscle fibres contribute to the phenomenon of increased insulin sensitivity...
Fri Sep 11, 2020 21:04
Abstract Objectives The growth of tooth dentin is incremental, so its formation represents a dietary record in early life. With archeological skeletons, applying sequential stable isotope analysis to the horizontal sections of tooth dentin has revealed weaning patterns and dietary changes that took place during childhood. However, the assignment of ages to dentin serial sections (DSSs) is problematic due to the changing extension rate and oblique growth layers of dentin, and these effects have...
Fri Sep 11, 2020 18:49
Abstract Objectives Social animals often have dominance hierarchies, with high rank conferring preferential access to resources. In primates, competition among males is often assumed to occur predominantly over reproductive opportunities. However, competition for food may occur during food shortages, such as in temperate species during winter. Higher‐ranked males may thus gain preferential access to high‐profitability food, which would enable them to spend longer engaged in activities...
Fri Sep 11, 2020 18:48
Abstract The histological identification of interglobular dentine (IGD) in archeological human remains with macroscopic evidence of rickets has opened a promising new avenue for the investigation of metabolic disease in the past. Recent paleopathological studies have shown that histological analysis of archeological human teeth may allow the identification of periods of vitamin D deficiency occurring within very narrow developmental windows, yielding new information on the seasonality...
Fri Sep 11, 2020 12:58
Abstract Objectives The analysis of prehistoric human dietary habits is key for understanding the effects of paleoenvironmental changes on the evolution of cultural and social human behaviors. In this study, we compare results from zooarchaeological, stable isotope and dental calculus analyses as well as lower second molar macrowear patterns to gain a broader understanding of the diet of three individuals who lived between the end of the Late Pleistocene and the Early Holocene (ca., 17–8 ky cal...
Fri Sep 11, 2020 12:57
Fri Sep 11, 2020 14:33
Background Pembrolizumab plus platinum‐based chemotherapy has demonstrated improved clinical outcomes over chemotherapy alone in patients with previously untreated advanced/metastatic non–small cell lung cancer (NSCLC), regardless of tumor programmed death ligand 1 (PD‐L1) expression. This study pooled data from 3 randomized controlled trials to evaluate outcomes with pembrolizumab plus chemotherapy versus chemotherapy alone in patients with advanced/metastatic NSCLC negative for PD‐L1 (ie, a tumor...
Fri Sep 11, 2020 14:33
Background Lorvotuzumab mertansine (IMGN901) is an antibody‐drug conjugate linking an antimitotic agent (DM1) to an anti‐CD56 antibody (lorvotuzumab). Preclinical efficacy has been noted in Wilms tumor, rhabdomyosarcoma, and neuroblastoma. Synovial sarcoma, malignant peripheral nerve sheath tumor (MPNST), and pleuropulmonary blastoma also express CD56. A phase 2 trial of lorvotuzumab mertansine was conducted to assess its efficacy, recommended phase 2 dose, and toxicities. Methods Eligible...
Fri Sep 11, 2020 14:33
Abstract Objectives It is not clear whether dopaminergic medication influences bruxism behaviour in patients with Parkinson’s disease (PD). Therefore, the aims are to investigate (i) the prevalence of possible (i.e., self-reported) bruxism (sleep and awake) in PD patients, and (ii) whether the use of dopaminergic medication and other factors (viz., demographic characteristics, PD-related factors, and possible consequences of bruxism) are...
Sat Sep 12, 2020 03:00
Schematic drawings comparing the MPN efferents between injected‐female (control) and injected‐OVX female groups. The interrupted lines show the decrease in the density of the projections in OVX group compared to the control group. Abstract Puberty is an important phase of development when the neural circuit organization is transformed by sexual hormones, inducing sexual dimorphism in adult behavioural responses. The principal brain area responsible for the control of the receptive component...
Fri Sep 11, 2020 13:11
Abstract Neuron orientation selectivity, otherwise known as the ability to respond optimally to a preferred orientation, has been extensively described in both primary and secondary visual cortices. This orientation selectivity, conserved through all cortical layers of a given column, is the primary basis for cortical organization and functional network emergence. While this selectivity is programmed and acquired since critical period, it has always been believed that in a mature brain, neurons’...
Fri Sep 11, 2020 22:35
Abstract Background This study aims to provide modern estimates of survival for untreated head and neck cancer (HNC) and to identify patient‐ and tumor‐specific factors associated with not receiving definitive treatment. Methods Adults with mucosal HNC were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Median overall survival of untreated patients was calculated and stratified by site and stage. Cause‐specific survival and factors associated with no treatment...
Fri Sep 11, 2020 22:59
Abstract The incidence of oral tongue squamous cell carcinoma has been increasing in young patients (≤45 years) without a clear etiologic driver. It is unknown if younger patients have an increased risk of recurrence compared to older patients. A literature search was conducted through January 2020 using PubMed/MEDLINE, Embase, Cochrane, Scopus, Science Direct, and clinicaltrials.gov. This review was registered with PROSPERO (ID: CRD42020167498) and the PRISMA statement was followed. Studies were...
Fri Sep 11, 2020 11:03
Abstract The role of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in head and neck cancer (HNC) prognosis is not well established. We conducted a systematic review focusing on MTV and TLG measured by 18F‐FDG positron‐emission tomography in HNC. Meta‐analyses were developed, estimating hazard ratios (HRs) for overall survival (OS) and disease‐free survival (DFS). Eighteen studies were found with a total of 1512 patients. MTV‐adjusted analysis had an HR of 4.65 (95% CI = 2.04‐10.6)...
Fri Sep 11, 2020 11:01
Objectives/Hypothesis Auricular reconstruction requiring manual contouring of costal cartilage is complex and time consuming, which could be facilitated by a robot in a fast and precise manner. This feasibility study evaluates the accuracy and speed of robotic contouring of cadaver costal cartilage. Methods An augmented robot with a spherical burr was used on cadaveric rib cartilage. Using a laser scanner, each rib section was converted to a three‐dimensional model for preoperative planning....
Fri Sep 11, 2020 22:29
Fri Sep 11, 2020 14:33
Living systems can form and recover complex chemical patterns with precisely sized features in the ranges of tens or hundreds of microns. We show how designed reaction‐diffusion processes can likewise produce precise patterns, termed attractor patterns, that reform their precise shape after being perturbed. We use oligonucleotide reaction networks, photolithography and microfluidic delivery to form precisely controlled attractor patterns and study the responses of these patterns to different localized...
Fri Sep 11, 2020 22:29
The membrane proximal external region (MPER) of HIV‐1 gp41 contains epitopes for at least four broadly neutralizing antibodies. Depending on solution conditions and construct design, different structures have been reported for this segment. We show that in aqueous solution the MPER fragment (gp160 660‐674 ) exists in a monomer‐trimer equilibrium with an association constant in the micro‐molar range. Thermodynamic analysis reveals that the association is exothermic, more favorable in D 2 O than...
Fri Sep 11, 2020 19:58
This work demonstrates photoredox vicinal dichlorination of alkenes, based on the homolysis of CuCl 2 in response to irradiation with visible light. This catalysis proceeds via a ligand to metal charge transfer process and provides an exciting opportunity for the synthesis of 1,2‐dichloride compounds using an inexpensive, low molecular weight chlorine source. This new process exhibits a wide substrate scope, excellent functional group tolerance, extraordinarily mild conditions and does not require...
Fri Sep 11, 2020 17:01
The glycan structures of the receptor binding domain of the SARS‐CoV2 spike glycoprotein expressed in human HEK293F cells have been studied by using NMR. The different possible interacting epitopes have been deeply analysed and characterized, providing evidence of the presence of glycan structures not found in previous MS‐based analyses. The interaction of the RBD 13C‐labelled glycans with different human lectins, which are expressed in different organs and tissues that may be affected during the...
Fri Sep 11, 2020 17:00
<p><p><p><p>Organic‐dye based NIR‐II fluorescent probes, owing to their high signal‐to‐background ratio and deeper penetration, are highly useful for deep‐tissue high‐contrast imaging in vivo. However, due to the lack of suitable dyes, it is still a challenge to design activatable NIR‐II fluorescent probes. In this work, we have designed a novel class of polymethine dyes (NIRII‐RTs) with bright (quantum yield up to 2.03%), stable and anti‐solvent quenching NIR‐II emission,...
Fri Sep 11, 2020 17:00
Nitrogenases reduce N 2 , the most abundant element in Earth’s atmosphere that is otherwise resistant to chemical conversions due to its stable triple bond. Vanadium nitrogenase stands out in that it additionally processes carbon monoxide, a known inhibitor of the more prominent molybdenum nitrogenase. The reduction of CO leads to the formation of hydrocarbon products, holding the potential for biotechnological applications in analogy to the industrial Fischer‐Tropsch process. Here we report the...
Fri Sep 11, 2020 16:23
The first application of piezoelectricity for the generation of trifluoromethyl (CF3) radicals is reported together with the development of a method for the mechanochemical C–H trifluoromethylation of aromatic compounds. Compared to conventional solution‐based approaches, this mechanoredox C–H trifluoromethylation enables cleaner and more sustainable access to a wide range of trifluoromethylated N‐heterocycles and peptides, which are important structural motifs in modern drug discovery. This study...
Fri Sep 11, 2020 15:29
The spatial organisation of functional components is essential for numerous biological and technical processes. Here, we report a novel 2D, interfacial micro‐compartmentalization strategy which is governed by 3D phase separation. In aqueous polyethylene glycol (PEG) solutions doped with biotinylated polymers, biotinylated polymers were serendipitously found to spontaneously accumulate in the interfacial layer between the oil‐surfactant‐water interface and the adjacent polymer phase. In aqueous two‐phase...
Fri Sep 11, 2020 14:00
Total synthesis of the plicamine‐type alkaloids zephycarinatines C and D has been achieved. The key feature of the synthesis is a stereoselective radical ipso‐cyclization using visible‐light‐mediated photoredox catalysis. Biological evaluation of zephycarinatines and their derivatives revealed that a synthetic derivative displays moderate inhibitory activity against LPS‐induced NO production. Abstract We report herein a nonbiomimetic strategy for the total synthesis of the plicamine‐type...
Fri Sep 11, 2020 13:35
The regioselectivity of the hydrocupration of α,β‐unsaturated carbonyl compounds can be reversed in the presence of an appropriate ancillary chiral ligand. This ligand‐controlled reversal of regiochemistry enables enantioselective and β‐selective hydroamination of α,β‐unsaturated carbonyl compounds, with 1,2‐benzisoxazole as an electrophilic aminating reagent, thereby providing simple and efficient access to N‐unprotected β‐amino acid derivatives. Abstract A Cu‐catalyzed enantioselective...
Fri Sep 11, 2020 12:42
To chemically modify proteins inside cells with an exogenously prepared, labeled backbone fragment we have explored the fastest splicing split intein. Excess intein reagent is removed to the nucleus to increase the signal‐to‐noise ratio in the cytoplasm. We report synthetic fluorophore attachment for super‐resolution and single‐molecule tracking studies. Abstract Protein semi‐synthesis inside live cells from exogenous and endogenous parts offers unique possibilities for studying proteins...
Fri Sep 11, 2020 12:42
The cation exchanged synthesis of diverse hollow metal‐phytate (PA) polyhedral complexes is reported using hollow Co2+‐PA micropolyhedra as templates in a liquid phase. The synthetic strategy enables facile addition of multiple functionalities within the metal‐PA polyhedral networks with simultaneous control of their physicochemical features under mild conditions. Abstract The ability to incorporate functional metal ions (M n+) into metal–organic coordination complexes adds remarkable...
Fri Sep 11, 2020 12:41
The development of isoform‐selective activity‐based probes enables the identification of enzyme activity within living systems. In this Minireview, key examples are highlighted and the relevance of isoform differentiation, design strategies, and applications are discussed. Abstract Until recently, there were no generalizable methods for assessing the effects of post‐translational regulation on enzymatic activity. Activity‐based sensing (ABS) has emerged as a powerful approach for monitoring...
Fri Sep 11, 2020 12:35
Electrophilic ketone activation: Triflic anhydride mediated activation of acetophenones leads to highly electrophilic intermediates undergoing various transformations with nucleophiles. The methodology gives access to α‐arylated and α‐oxyaminated acetophenones under metal‐free conditions in moderate to excellent yields. Abstract Triflic anhydride mediated activation of acetophenones leads to highly electrophilic intermediates that can undergo a variety of transformations when treated with...
Fri Sep 11, 2020 12:34
A versatile kinetic resolution of protecting‐group‐free BINAMs and NOBINs has been realized through chiral phosphoric acid catalyzed triazane formation with azodicarboxylates. A series of mono‐N‐protected and unprotected BINAMs, diphenyl diamines and NOBIN derivatives could be kinetically resolved with excellent performances (with s factor up to 420). The gram‐scale reactions and facile derivatizations of the chiral products demonstrate the potential of these methods in the asymmetric synthesis of...
Fri Sep 11, 2020 12:30
An enantiomerically pure additive can direct chiral symmetry breaking towards opposite outcomes, depending on the relative contributions of kinetic and thermodynamic processes. Kinetic growth inhibition directs symmetry breaking towards the enantiomer of the opposite configuration to the additive, whereas thermodynamic solid solution formation favors the same absolute configuration, thus offering a mechanism for the propagation of homochirality. Abstract Propagation of homochirality plays...
Fri Sep 11, 2020 12:19
The Li‐O2 battery can be photoactivated, thus reducing the recharge potential to 2.7 V with a binder‐ and carbon‐free TiO2‐based oxygen electrode, which also enhances the stability of the system. The electrode exhibits excellent stability with about 100 % coulombic efficiency during continuous cycling of up to 200 cycles. This work reveals a new strategy towards the development of highly efficient oxygen electrode materials for Li‐O2 batteries. Abstract The practical applications of non‐aqueous...
Fri Sep 11, 2020 12:18
The relationships between zeolite channel geometries and reaction intermediates are reported here. Anisotropic zeolite ZSM‐5 crystals were used to enable the preferential formation of reaction intermediates in single‐orientation zeolite channels for the methanol‐to‐hydrocarbon (MTH) process. Advanced solid‐state NMR spectroscopy showed that the more constrained sinusoidal zeolite channels favor the olefin cycle, whereas the more extended straight zeolite channels facilitate the aromatic cycle....
Fri Sep 11, 2020 12:18
A single catalytic platform is described for which control of 1,2 versus 1,4 selectivity for enone hydroboration can be controlled by light. This was used to obtain rare syn‐aldol products on cyclic substrates. Experiments and DFT calculations demonstrate that two distinctive mechanisms are operative. Abstract Selectivity between 1,2 and 1,4 addition of a nucleophile to an α,β‐unsaturated carbonyl compound has classically been modified by the addition of stoichiometric additives to the...
Fri Sep 11, 2020 12:18
Direct synthesis of Ga‐ZSM‐5 catalysts leads to dramatic enhancement in the production of aromatics from ethylene compared to post‐synthesis preparation methods. Combined experiments and modeling reveal an energetic preference for Ga extra‐framework sites to associate with select framework sites, suggesting the possibility of tailoring Lewis acid siting in zeolites by controlled heteroatom substitution in framework tetrahedral sites. Abstract Bifunctional catalysis in zeolites possessing...
Fri Sep 11, 2020 12:17
The first example of tetracyanobuta‐1,3‐diene‐based derivatives, showing unprecedented configurational stability and a peculiar light‐triggered enantiomer conversion mechanism enabled by triple‐state photogeneration, is reported. Abstract In recent years, several tetracyanobuta‐1,3‐diene (TCBD) conjugates have been prepared by linking the tetracyano unit to various electroactive moieties. These push–pull conjugates, besides showing interesting physicochemical properties, are axially chiral,...
Fri Sep 11, 2020 12:16
An automated electrochemistry screening platform based on a single‐droplet microfluidic reactor enables multifunctional capabilities for investigation of electroorganic synthesis. Reaction condition screening of an electrochemical radical–radical cross‐coupling reaction and measurements of kinetics for two mediated anodic oxidation reactions are realized with fast turnover time and minimal reagent consumption. Abstract Electroorganic synthesis is a promising tool to design sustainable transformations...
Fri Sep 11, 2020 12:16
A low‐symmetry organic molecular cage with distinctive geometry was successfully synthesized through the desymmetrized vertex design strategy. Abstract A novel low‐symmetry organic molecular cage with distinctive geometry was successfully synthesized from 5,5′‐(propane‐2,2‐diyl)bis(2‐hydroxyisophthalaldehyde) and 1,2‐cyclohexanediamine building blocks, through the desymmetrized vertex design strategy. Single‐crystal X‐ray crystallographic analysis shows that the cage contains asymmetrical...
Fri Sep 11, 2020 12:15
Radical‐Cation Cascade to Aryltetralin Cyclic Ether Lignans Under Visible‐Light Photoredox Catalysis
Under blue LED irradiation, dicinnamyl ether derivatives undergo double cyclization to afford tricyclic lignans. Six natural products are synthesized from the corresponding monolignols in two or three steps. Abstract The development of concise, sustainable, and cost‐effective synthesis of aryltetralin lignans, bearing either a fused lactone or cyclic ether, is of significant medicinal importance. Reported is that in the presence of Fukuzumi's acridinium salt under blue LED irradiation,...
Fri Sep 11, 2020 12:14
Single‐molecule FRET experiments show that the structure of the peptide membrane transporter DtpA is tuned by membrane composition. Head‐group chemistry determines which of three alternative conformations dominates. An extreme cytoplasmic opening is observed with anionic head groups. Abstract Membrane proteins require lipid bilayers for function. While lipid compositions reach enormous complexities, high‐resolution structures are usually obtained in artificial detergents. To understand...
Fri Sep 11, 2020 12:13
By growing amorphous multi‐transition‐metal (cobalt and iron) oxide on two‐dimensional (2D) black phosphorus (BP), a bifunctional electrocatalyst (CoFeO@BP), which is able to efficiently catalyze both HER and OER was developed. The overpotentials for the hybrid CoFeO@BP catalyst to reach a current density of 10 mA cm−2 in 1 m KOH are 88 and 266 mV for HER and OER, respectively. Abstract Water electrolysis offers a promising green technology to tackle the global energy and environmental...
Fri Sep 11, 2020 12:12
Supercritical water possesses vastly different properties compared to its liquid phase, for instance it is well known that the famous tetrahedral H‐bond network is destroyed. In their Research Article (DOI: https://doi.org/10.1002/anie.20200964010.1002/anie.202009640), P. Schienbein and D. Marx further unveil that supercritical water should not be considered as a H‐bonded fluid at all due to ultrafast reorientational dynamics on the timescale of intermolecular H‐bond vibrations. Instead, it behaves...
Fri Sep 11, 2020 12:12
Bis(perchlorocatecholato)germane is a hard and soft Lewis superacid with unlimited water stability. Its utility in catalysis as both a Lewis and Brønsted acid was demonstrated by application to a variety of catalytic transformations, such as hydrodefluorination, hydrosilylation, transfer hydrogenation, and carbonyl–olefin metathesis. Abstract Previously described Lewis superacids are moisture sensitive and predominantly hard in character—features that severely limit their widespread use...
Fri Sep 11, 2020 12:12
An open‐framework semiconductor is demonstrated to have an advantage over its dense‐phase counterpart for an optimal balance between the resistivity and band gap to target high‐performance X‐ray detection. Sulfur‐doped zeolitic In–Se gives rise to an excellent X‐ray detector with a high figure of merit for the mobility–lifetime product (μτ, 7.12×10−4 cm2 V−1), which is superior to that obtained with a commercial α‐Se detector. Abstract A wide range of tunability in the physical parameters...
Fri Sep 11, 2020 12:11
An organocatalytic enantioselective [2,3]‐sigmatropic rearrangement is described. This reaction enables chiral cyclic sulfides bearing an α‐quaternary chiral center to be prepared in high optical purity. The enantioselectivity is controlled by a cooperative organocatalyst pair consisting of a chiral amine and a chiral phosphoric acid (CPA). NIS=N‐iodosuccinimide. Abstract The rearrangement of sulfur‐containing aldehydes by using a sulfonium enamine intermediate as a formylcarbene mimetic...
Fri Sep 11, 2020 12:09
The catalytic reactivity and lability of atomically precise Au25 nanoclusters was investigated by monitoring the movement of a free valence electron of the Au 6s orbital. Donation of an electron to a neutral Au25 0 nanocluster generates Au25 − with undermined reactivity, whereas dislodgment of an electron generates Au25 + with undermined stability. The correlation of the free valence electrons and catalytic properties of the Au25 nanoclusters can be achieved at a single‐electron level. ...
Fri Sep 11, 2020 12:07
The addition of N‐heterocyclic carbenes on Ru/C induces a catalytic activity switch to favor hydrogen isotope exchange over reductive deuteration. This catalyst modification led to an increase in regio‐ and chemoselectivity in the context of the C−H deuteration of pharmaceutically relevant substructures, as well as to the discovery of a novel reactivity for such heterogeneous Ru catalysts, namely selective C‐1 deuteration of aldehydes. Abstract We report the dramatic impact of the addition...
Fri Sep 11, 2020 12:06
Steam and dry reforming of methane catalyzed by gas‐phase rhodium–vanadium–oxygen cluster anions at room temperature with high syngas selectivity has been identified under photo‐irradiation conditions. The crucial step to govern syngas selectivity is the photo‐excitation of reaction intermediates such as Rh2VO3CH2 − to electronically excited states that selectively produce H2 and CO. Abstract Photoassisted steam reforming and dry (CO2) reforming of methane (SRM and DRM) at room temperature...
Fri Sep 11, 2020 12:06
A thin and well‐intergrown zeolitic imidazolate framework (ZIF‐95) membrane was developed for H2 separation. A simple vapor‐assisted in‐plane epitaxial growth method generated a highly oriented ZIF‐95 membrane. A notable reduction of intercrystalline defects and transport pathways was achieved compared to a randomly oriented ZIF‐95 framework, resulting in a 4.6 times enhancement of H2 permeance for the separation of H2 (0.29 nm) from larger gas molecules. Abstract Control of the microstructure...
Fri Sep 11, 2020 12:04
A tumor microenvironment (TME) stimuli‐responsive fluorescence imaging and trimodal synergistic cancer treatment nanoplatform is facilely constructed via assembling carbon dots and Cu2+. This could act as a potential strategy to achieve enhanced cancer therapeutic efficiency with minimized side effects. Abstract A method is developed to fabricate tumor microenvironment (TME) stimuli‐responsive nanoplatform for fluorescence (FL) imaging and synergistic cancer therapy via assembling photosensitizer...
Fri Sep 11, 2020 12:04
An efficient method for photocatalytic perfluoroalkylation of vinyl‐substituted all‐carbon quaternary centers involving 1,2‐aryl migration has been developed. The rearrangement reactions use fac‐Ir(ppy) 3 , visible light and commercially available fluoroalkyl halides and can generate valuable multisubstituted perfluoroalkylated compounds in a single step that would be challenging to prepare by other methods. Mechanistically, the photoinduced alkyl radical addition to an alkene leads to the migration...
Fri Sep 11, 2020 12:01
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