IJMS, Vol. 21, Pages 6728: Can miRNAs Be Considered as Diagnostic and Therapeutic Molecules in Ischemic Stroke Pathogenesis?—Current Status International Journal of Molecular Sciences doi: 10.3390/ijms21186728 Authors: Bulygin Beeraka Saitgareeva Nikolenko Gareev Beylerli Akhmadeeva Mikhaleva Torres Solis Solís Herrera Avila-Rodriguez Somasundaram Kirkland Aliev Ischemic stroke is one of the leading causes of death worldwide. Clinical...
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IJMS, Vol. 21, Pages 6726: In Vitro Innovation of Tendon Tissue Engineering Strategies International Journal of Molecular Sciences doi: 10.3390/ijms21186726 Authors: Citeroni Ciardulli Russo Della Porta Mauro El Khatib Di Mattia Galesso Barbera Forsyth Maffulli Barboni Tendinopathy is the term used to refer to tendon disorders. Spontaneous adult tendon healing results in scar tissue formation and fibrosis with suboptimal biomechanical properties,...
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IJMS, Vol. 21, Pages 6724: HisCoM-G×E: Hierarchical Structural Component Analysis of Gene-Based Gene–Environment Interactions International Journal of Molecular Sciences doi: 10.3390/ijms21186724 Authors: Choi Lee Huh Hwang Park Gene–environment interaction (G×E) studies are one of the most important solutions for understanding the “missing heritability” problem in genome-wide association studies (GWAS). Although many statistical...
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IJMS, Vol. 21, Pages 6725: C-Terminal Extensions of Ku70 and Ku80 Differentially Influence DNA End Binding Properties International Journal of Molecular Sciences doi: 10.3390/ijms21186725 Authors: Takabumi Inagawa Thomas Wennink Joyce H. G. Lebbink Guido Keijzers Bogdan I. Florea Nicole S. Verkaik Dik C. van Gent The Ku70/80 heterodimer binds to DNA ends and attracts other proteins involved in the non-homologous end-joining (NHEJ) pathway of DNA double-strand break...
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IJMS, Vol. 21, Pages 6722: Analyzing Gene Expression Profiles from Ataxia and Spasticity Phenotypes to Reveal Spastic Ataxia Related Pathways International Journal of Molecular Sciences doi: 10.3390/ijms21186722 Authors: Andrea C. Kakouri Christina Votsi Marios Tomazou George Minadakis Evangelos Karatzas Kyproula Christodoulou George M. Spyrou Spastic ataxia (SA) is a group of rare neurodegenerative diseases, characterized by mixed features of generalized ataxia and...
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IJMS, Vol. 21, Pages 6721: Characterization and Evaluation of Bone-Derived Nanoparticles as a Novel pH-Responsive Carrier for Delivery of Doxorubicin into Breast Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21186721 Authors: Sheikh Tanzina Haque Rowshan Ara Islam Siew Hua Gan Ezharul Hoque Chowdhury Background: The limitations of conventional treatment modalities in cancer, especially in breast cancer, facilitated the necessity for developing a safer...
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IJMS, Vol. 21, Pages 6723: Pathogenic Mechanisms of Myeloma Bone Disease and Possible Roles for NRF2
IJMS, Vol. 21, Pages 6723: Pathogenic Mechanisms of Myeloma Bone Disease and Possible Roles for NRF2 International Journal of Molecular Sciences doi: 10.3390/ijms21186723 Authors: Chia-Hung Yen Chin-Mu Hsu Samuel Yien Hsiao Hui-Hua Hsiao Osteolytic bone lesions are one of the central features of multiple myeloma (MM) and lead to bone pain, fractures, decreased quality of life, and decreased survival. Dysfunction of the osteoclast (OC)/osteoblast (OB) axis plays a key role in...
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IJMS, Vol. 21, Pages 6719: The Pathopharmacological Interplay between Vanadium and Iron in Parkinson’s Disease Models International Journal of Molecular Sciences doi: 10.3390/ijms21186719 Authors: Samuel Ohiomokhare Francis Olaolorun Amany Ladagu Funmilayo Olopade Melanie-Jayne R. Howes Edward Okello James Olopade Paul L. Chazot Parkinson’s disease (PD) pathology is characterised by distinct types of cellular defects, notably associated with oxidative damage and...
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IJMS, Vol. 21, Pages 6691: Pre-Operative Evaluation of DNA Methylation Profile in Oral Squamous Cell Carcinoma Can Predict Tumor Aggressive Potential International Journal of Molecular Sciences doi: 10.3390/ijms21186691 Authors: Davide Gissi Viscardo Fabbri Andrea Gabusi Jacopo Lenzi Luca Morandi Sofia Melotti Sofia Asioli Achille Tarsitano Tiziana Balbi Claudio Marchetti Lucio Montebugnoli Background: Prognosis of oral squamous cell carcinoma (OSCC) is...
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IJMS, Vol. 21, Pages 6720: Non-Coding RNAs as Cancer Hallmarks in Chronic Lymphocytic Leukemia International Journal of Molecular Sciences doi: 10.3390/ijms21186720 Authors: Linda Fabris Jaroslav Juracek George Calin The discovery of non-coding RNAs (ncRNAs) and their role in tumor onset and progression has revolutionized the way scientists and clinicians study cancers. This discovery opened new layers of complexity in understanding the fine-tuned regulation of cellular processes...
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IJMS, Vol. 21, Pages 6718: Recent Advances in Cell-Based Therapies for Ischemic Stroke International Journal of Molecular Sciences doi: 10.3390/ijms21186718 Authors: Satoshi Suda Chikako Nito Shoji Yokobori Yuki Sakamoto Masataka Nakajima Kota Sowa Hirofumi Obinata Kazuma Sasaki Sean I. Savitz Kazumi Kimura Stroke is the most prevalent cardiovascular disease worldwide, and is still one of the leading causes of death and disability. Stem cell-based therapy is...
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IJMS, Vol. 21, Pages 6717: Impact of KLF4 on Cell Proliferation and Epithelial Differentiation in the Context of Cystic Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms21186717 Authors: Luís Sousa Ines Pankonien Filipa B. Simões Marc Chanson Margarida D. Amaral Cystic fibrosis (CF) cells display a more cancer-like phenotype vs. non-CF cells. KLF4 overexpression has been described in CF and this transcriptional factor acts as a negative regulator of wt-CFTR....
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IJMS, Vol. 21, Pages 6716: Mismatch-Repair Protein Expression in High-Grade Gliomas: A Large Retrospective Multicenter Study International Journal of Molecular Sciences doi: 10.3390/ijms21186716 Authors: Mario Caccese Tamara Ius Matteo Simonelli Matteo Fassan Daniela Cesselli Angelo Dipasquale Francesco Cavallin Marta Padovan Alessandro Salvalaggio Marina Paola Gardiman Miran Skrap Vittorina Zagonel Giuseppe Lombardi Background: DNA mismatch repair...
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IJMS, Vol. 21, Pages 6715: Age and Sex-Dependent ADNP Regulation of Muscle Gene Expression Is Correlated with Motor Behavior: Possible Feedback Mechanism with PACAP International Journal of Molecular Sciences doi: 10.3390/ijms21186715 Authors: Oxana Kapitansky Shlomo Sragovich Iman Jaljuli Adva Hadar Eliezer Giladi Illana Gozes The activity-dependent neuroprotective protein (ADNP), a double-edged sword, sex-dependently regulates multiple genes and was previously associated...
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IJMS, Vol. 21, Pages 6714: Doubly-Charged Negative Ions as Novel Tunable Catalysts: Graphene and Fullerene Molecules Versus Atomic Metals International Journal of Molecular Sciences doi: 10.3390/ijms21186714 Authors: Kelvin Suggs Alfred Z. Msezane The fundamental mechanism underlying negative-ion catalysis involves bond-strength breaking in the transition state (TS). Doubly-charged atomic/molecular anions are proposed as novel dynamic tunable catalysts, as demonstrated in water oxidation...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6712: Toll-Like Receptor as a Potential Biomarker in Renal Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21186712 Authors: Sebastian Mertowski Paulina Lipa Izabela Morawska Paulina Niedźwiedzka-Rystwej Dominika Bębnowska Rafał Hrynkiewicz Ewelina Grywalska Jacek Roliński Wojciech Załuska One of the major challenges faced by modern nephrology is the identification of biomarkers associated with histopathological patterns...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6710: Molecular Alterations in Spermatozoa of a Family Case Living in the Land of Fires. A First Look at Possible Transgenerational Effects of Pollutants International Journal of Molecular Sciences doi: 10.3390/ijms21186710 Authors: Gennaro Lettieri Federica Marra Claudia Moriello Marina Prisco Tiziana Notari Marco Trifuoggi Antonella Giarra Liana Bosco Luigi Montano Marina Piscopo In our previous work, we reported alterations in protamines/histones...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6713: Functional Characterization of Temporin-SHe, a New Broad-Spectrum Antibacterial and Leishmanicidal Temporin-SH Paralog from the Sahara Frog (Pelophylax saharicus) International Journal of Molecular Sciences doi: 10.3390/ijms21186713 Authors: Sonia André Zahid Raja Vincent Humblot Christophe Piesse Thierry Foulon Denis Sereno Bruno Oury Ali Ladram Amphibian skin is a promising natural resource for antimicrobial peptides (AMPs), key effectors...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6711: Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites International Journal of Molecular Sciences doi: 10.3390/ijms21186711 Authors: Małgorzata Gazińska Anna Krokos Magdalena Kobielarz Marcin Włodarczyk Paulina Skibińska Bogusz Stępak Arkadiusz Antończak Milena Morawiak Przemysław Płociński Karolina Rudnicka Novel biocomposites...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6709: Identification, Characterization, and Genomic Analysis of Novel Serratia Temperate Phages from a Gold Mine International Journal of Molecular Sciences doi: 10.3390/ijms21186709 Authors: Katarzyna Bujak Przemyslaw Decewicz Jerzy Kaminski Monika Radlinska Bacteria of the genus Serratia inhabit a variety of ecological niches like water, soil, and the bodies of animals, and have a wide range of lifestyles. Currently, the complete genome sequences of 25...
Sun Sep 13, 2020 03:00
Cells, Vol. 9, Pages 2094: Cell Biological Techniques and Cell-Biomaterial Interactions Cells doi: 10.3390/cells9092094 Authors: Yunqing Kang Biomaterials play a key role in modern tissue engineering and regenerative medicine. They are expected to take over the function of a damaged tissue in the long term, trigger the self-healing potential of the body, and biodegrade at an appropriate rate. To meet these requirements, it is imperative to understand the cell-biomaterial interactions...
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IJMS, Vol. 21, Pages 6707: Functional Characterization of a Putative RNA Demethylase ALKBH6 in Arabidopsis Growth and Abiotic Stress Responses International Journal of Molecular Sciences doi: 10.3390/ijms21186707 Authors: Trinh Thi Huong Le Nguyen Tieu Ngoc Hunseung Kang RNA methylation and demethylation, which is mediated by RNA methyltransferases (referred to as “writers”) and demethylases (referred to as “erasers”), respectively, are emerging...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6706: Cinobufagin Suppresses Melanoma Cell Growth by Inhibiting LEF1 International Journal of Molecular Sciences doi: 10.3390/ijms21186706 Authors: Geon-Hee Kim Xue-Quan Fang Woo-Jin Lim Jooho Park Tae-Bong Kang Ji Hyung Kim Ji-Hong Lim Constitutive activation of the β-catenin dependent canonical Wnt signaling pathway, which enhances tumor growth and progression in multiple types of cancer, is commonly observed in melanoma. LEF1 activates...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6708: Intra-Tumoral Angiogenesis Is Associated with Inflammation, Immune Reaction and Metastatic Recurrence in Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21186708 Authors: Masanori Oshi Stephanie Newman Yoshihisa Tokumaru Li Yan Ryusei Matsuyama Itaru Endo Masayuki Nagahashi Kazuaki Takabe Angiogenesis is one of the hallmarks of cancer. We hypothesized that intra-tumoral angiogenesis correlates with inflammation...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6704: Influence of the Casting Concentration on the Mechanical and Optical Properties of FA/CaCl2-Derived Silk Fibroin Membranes International Journal of Molecular Sciences doi: 10.3390/ijms21186704 Authors: Alexander Kopp Laura Schunck Martin Gosau Ralf Smeets Simon Burg Sandra Fuest Nadja Kröger Max Zinser Sebastian Krohn Mehdi Behbahani Marius Köpf Lisa Lauts Rico Rutkowski In this study, we describe the manufacturing and characterization...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6700: Genetic and Methylome Variation in Turkish Brachypodium Distachyon Accessions Differentiate Two Geographically Distinct Subpopulations International Journal of Molecular Sciences doi: 10.3390/ijms21186700 Authors: Aleksandra Skalska Christoph Stritt Michele Wyler Hefin W. Williams Martin Vickers Jiwan Han Metin Tuna Gulsemin Savas Tuna Karolina Susek Martin Swain Rafał K. Wóycicki Saurabh Chaudhary Fiona Corke John H. Doonan...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6702: Host Synthesized Carbohydrate Antigens on Viral Glycoproteins as “Achilles’ Heel” of Viruses Contributing to Anti-Viral Immune Protection International Journal of Molecular Sciences doi: 10.3390/ijms21186702 Authors: Uri Galili The glycans on enveloped viruses are synthesized by host-cell machinery. Some of these glycans on zoonotic viruses of mammalian reservoirs are recognized by human natural antibodies that may protect against such viruses. These antibodies...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6703: The Expression Profile of mRNA and tRNA Genes in Splenocytes and Neutrophils after In Vivo Delivery of Antitumor Short Hairpin RNA of Indoleamine 2,3- Dioxygenase International Journal of Molecular Sciences doi: 10.3390/ijms21186703 Authors: Ming-Shyan Huang Ya-Ling Hsu I-Jeng Yeh Kuan-Ting Liu Meng-Chi Yen RNA-based therapeutics are considered as novel treatments for human diseases. Our previous study demonstrated that treatment with short-hairpin...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6705: A Possible Role of FZD10 Delivering Exosomes Derived from Colon Cancers Cell Lines in Inducing Activation of Epithelial–Mesenchymal Transition in Normal Colon Epithelial Cell Line International Journal of Molecular Sciences doi: 10.3390/ijms21186705 Authors: Maria Principia Scavo Federica Rizzi Nicoletta Depalo Elisabetta Fanizza Chiara Ingrosso Maria Lucia Curri Gianluigi Giannelli Exosomes belong to the family of extracellular vesicles released...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6701: Anti-PD-1 Therapy Does Not Influence Hearing Ability in the Most Sensitive Frequency Range, but Mitigates Outer Hair Cell Loss in the Basal Cochlear Region International Journal of Molecular Sciences doi: 10.3390/ijms21186701 Authors: Judit Szepesy Gabriella Miklós János Farkas Dániel Kucsera Zoltán Giricz Anita Gáborján Gábor Polony Ágnes Szirmai László Tamás László Köles Zoltán V. Varga Tibor Zelles The administration of immune...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6699: Dihydromyricetin Improves Endothelial Dysfunction in Diabetic Mice via Oxidative Stress Inhibition in a SIRT3-Dependent Manner International Journal of Molecular Sciences doi: 10.3390/ijms21186699 Authors: Yu-Yun Hua Yue Zhang Wei-Wei Gong Yue Ding Jie-Ru Shen Hua Li Yun Chen Guo-Liang Meng Dihydromyricetin (DHY), a flavonoid component isolated from Ampelopsis grossedentata, exerts versatile pharmacological activities. However, the possible...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6698: Predicting Nonalcoholic Fatty Liver Disease through a Panel of Plasma Biomarkers and MicroRNAs in Female West Virginia Population International Journal of Molecular Sciences doi: 10.3390/ijms21186698 Authors: Sneha S. Pillai Hari Vishal Lakhani Mishghan Zehra Jiayan Wang Anum Dilip Nitin Puri Kathleen O’Hanlon Komal Sodhi (1) Background: Nonalcoholic fatty liver disease (NAFLD) is primarily characterized by the presence of fatty liver,...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6697: Insights into the Selectivity Mechanisms of Grapevine NIP Aquaporins International Journal of Molecular Sciences doi: 10.3390/ijms21186697 Authors: Farzana Sabir Antonella Di Pizio Maria C. Loureiro-Dias Angela Casini Graça Soveral Catarina Prista Nodulin 26-like intrinsic proteins (NIPs) of the plant aquaporin family majorly facilitate the transport of physiologically relevant solutes. The present study intended to investigate how substrate...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6696: Nasal Immunization with the C-Terminal Domain of Bcla3 Induced Specific IgG Production and Attenuated Disease Symptoms in Mice Infected with Clostridioides difficile Spores International Journal of Molecular Sciences doi: 10.3390/ijms21186696 Authors: Ana Raquel Maia Rodrigo Reyes-Ramírez Marjorie Pizarro-Guajardo Anella Saggese Ezio Ricca Loredana Baccigalupi Daniel Paredes-Sabja Clostridioides difficile is a Gram-positive, spore-forming...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6695: Disorders of Human Coenzyme Q10 Metabolism: An Overview International Journal of Molecular Sciences doi: 10.3390/ijms21186695 Authors: Iain Hargreaves Robert A. Heaton David Mantle Coenzyme Q10 (CoQ10) has a number of vital functions in all cells, both mitochondrial and extramitochondrial. In addition to its key role in mitochondrial oxidative phosphorylation, CoQ10 serves as a lipid soluble antioxidant, plays an important role in fatty acid, pyrimidine...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6694: Integrated Analysis to Study the Relationship between Tumor-Associated Selenoproteins: Focus on Prostate Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21186694 Authors: Francesca Capone Andrea Polo Angela Sorice Alfredo Budillon Susan Costantini Selenoproteins are proteins that contain selenium within selenocysteine residues. To date, twenty-five mammalian selenoproteins have been identified; however, the functions of nearly...
Sun Sep 13, 2020 03:00
IJMS, Vol. 21, Pages 6693: Agonist Binding and G Protein Coupling in Histamine H2 Receptor: A Molecular Dynamics Study International Journal of Molecular Sciences doi: 10.3390/ijms21186693 Authors: Marcus Conrad Christian A. Söldner Yinglong Miao Heinrich Sticht The histamine H2 receptor (H2R) plays an important role in the regulation of gastric acid secretion. Therefore, it is a main drug target for the treatment of gastroesophageal reflux or peptic ulcer disease. However,...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6685: Characterization of Rat Cardiovascular System by Anacrotic/Dicrotic Notches in the Condition of Increase/Decrease of NO Bioavailability International Journal of Molecular Sciences doi: 10.3390/ijms21186685 Authors: Lenka Tomasova Anton Misak Lucia Kurakova Marian Grman Karol Ondrias We characterized modes of action of NO-donor S-nitrosoglutathione (GSNO) and NO-synthase inhibitor l-NAME derived from dicrotic (DiN) and anacrotic (AnN) notches of...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6692: Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells International Journal of Molecular Sciences doi: 10.3390/ijms21186692 Authors: Yang Gao Pengbo Wen Bin Chen Guanshuo Hu Lijun Wu An Xu Guoping Zhao Radiotherapy is an important modality for the local control of human cancers, but the radioresistance induced by aberrant apoptotic signaling is a hallmark of cancers. Restoring...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6690: The New Paradigm of Network Medicine to Analyze Breast Cancer Phenotypes International Journal of Molecular Sciences doi: 10.3390/ijms21186690 Authors: Anna Maria Grimaldi Federica Conte Katia Pane Giulia Fiscon Peppino Mirabelli Simona Baselice Rosa Giannatiempo Francesco Messina Monica Franzese Marco Salvatore Paola Paci Mariarosaria Incoronato Breast cancer (BC) is a heterogeneous and complex disease as witnessed by the existence...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6674: Comment on: Food for Bone: Evidence for a Role for Delta-Tocotrienol in the Physiological Control of Osteoblast Migration. Int. J. Mol. Sci. 2020, 21, 4661 International Journal of Molecular Sciences doi: 10.3390/ijms21186674 Authors: Kok-Lun Pang Kok-Yong Chin Dear Editor, [...]
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6686: The Role of Sirtuins in Kidney Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21186686 Authors: Yu Ah Hong Ji Eun Kim Minjee Jo Gang-Jee Ko Sirtuins (SIRTs) are class III histone deacetylases (HDACs) that play important roles in aging and a wide range of cellular functions. Sirtuins are crucial to numerous biological processes, including proliferation, DNA repair, mitochondrial energy homeostasis, and antioxidant activity. Mammals...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6688: Blocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial Sepsis International Journal of Molecular Sciences doi: 10.3390/ijms21186688 Authors: Hemant K. Mishra Jing Ma Daniel Mendez Robert Hullsiek Nabendu Pore Bruce Walcheck Sepsis is the culmination of hyperinflammation and immune suppression in response to severe infection. Neutrophils are critical early responders to bacterial infection...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6689: Formation and Recognition of UV-Induced DNA Damage within Genome Complexity International Journal of Molecular Sciences doi: 10.3390/ijms21186689 Authors: Philippe Johann to Berens Jean Molinier Ultraviolet (UV) light is a natural genotoxic agent leading to the formation of photolesions endangering the genomic integrity and thereby the survival of living organisms. To prevent the mutagenetic effect of UV, several specific DNA repair mechanisms are mobilized...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6683: Mechanisms Underlying the Regulation of Mitochondrial Respiratory Chain Complexes by Nuclear Steroid Receptors International Journal of Molecular Sciences doi: 10.3390/ijms21186683 Authors: Ami Kobayashi Kotaro Azuma Kazuhiro Ikeda Satoshi Inoue Mitochondrial respiratory chain complexes play important roles in energy production via oxidative phosphorylation (OXPHOS) to drive various biochemical processes in eukaryotic cells. These processes require...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6687: p-Cresol Sulfate Caused Behavior Disorders and Neurodegeneration in Mice with Unilateral Nephrectomy Involving Oxidative Stress and Neuroinflammation International Journal of Molecular Sciences doi: 10.3390/ijms21186687 Authors: Chiao-Yin Sun Jian-Ri Li Ya-Yu Wang Shih-Yi Lin Yen-Chuan Ou Cheng-Jui Lin Jiaan-Der Wang Su-Lan Liao Chun-Jung Chen Protein-bound uremic toxins, such as p-cresol sulfate (PCS), can be accumulated with declined...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6682: The Hidden Fragility in the Heart of the Athletes: A Review of Genetic Biomarkers International Journal of Molecular Sciences doi: 10.3390/ijms21186682 Authors: Ferdinando Barretta Bruno Mirra Emanuele Monda Martina Caiazza Barbara Lombardo Nadia Tinto Olga Scudiero Giulia Frisso Cristina Mazzaccara Sudden cardiac death (SCD) is a devastating event which can also affect people in apparent good health, such as young athletes. It is known...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6684: Inhibition of DNA Repair in Cancer Therapy: Toward a Multi-Target Approach International Journal of Molecular Sciences doi: 10.3390/ijms21186684 Authors: Samuele Lodovichi Tiziana Cervelli Achille Pellicioli Alvaro Galli Alterations in DNA repair pathways are one of the main drivers of cancer insurgence. Nevertheless, cancer cells are more susceptible to DNA damage than normal cells and they rely on specific functional repair pathways to survive. Thanks...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6681: Bioinformatic Characterization of Sulfotransferase Provides New Insights for the Exploitation of Sulfated Polysaccharides in Caulerpa International Journal of Molecular Sciences doi: 10.3390/ijms21186681 Authors: Simone Landi Sergio Esposito Caulerpa is an unusual algal genus from Caulerpaceae (Chlorophyta, Bryopsidales). Species from this family produce a wide range of metabolites suitable for biotechnology applications. Among these, sulfated polysaccharides...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6680: Extracellular Vesicles in Bone Metastasis: Key Players in the Tumor Microenvironment and Promising Therapeutic Targets International Journal of Molecular Sciences doi: 10.3390/ijms21186680 Authors: Takaaki Tamura Yusuke Yoshioka Shinichi Sakamoto Tomohiko Ichikawa Takahiro Ochiya Extracellular vesicles (EVs) are lipid membranous vesicles that are released from every type of cell. It has become clear that EVs are involved in a variety of biological...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6679: Overview of Current Advances in Extrusion Bioprinting for Skin Applications International Journal of Molecular Sciences doi: 10.3390/ijms21186679 Authors: Arantza Perez-Valle Cristina Del Amo Isabel Andia Bioprinting technologies, which have the ability to combine various human cell phenotypes, signaling proteins, extracellular matrix components, and other scaffold-like biomaterials, are currently being exploited for the fabrication of human skin in regenerative...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6677: Prion Protein at the Leading Edge: Its Role in Cell Motility International Journal of Molecular Sciences doi: 10.3390/ijms21186677 Authors: Mariana Brandão Prado Maria Isabel Melo Escobar Rodrigo Nunes Alves Bárbara Paranhos Coelho Camila Felix de Lima Fernandes Jacqueline Marcia Boccacino Rebeca Piatniczka Iglesia Marilene Hohmuth Lopes Cell motility is a central process involved in fundamental biological phenomena during embryonic development,...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6678: Aldehyde Dehydrogenase 2 Ameliorates Chronic Alcohol Consumption-Induced Atrial Fibrillation through Detoxification of 4-HNE International Journal of Molecular Sciences doi: 10.3390/ijms21186678 Authors: Lung-An Hsu Feng-Chun Tsai Yung-Hsin Yeh Chi-Jen Chang Chi-Tai Kuo Wei-Jan Chen Hsin-Yi Tsai Gwo-Jyh Chang Aldehyde dehydrogenase 2 (ALDH2) is an enzyme that detoxifies reactive oxygen species (ROS)-generated aldehyde adducts such as 4-hydroxy-trans-2-nonenal...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6675: Reply “Comment on: Food for Bone: Evidence for a Role for Delta-Tocotrienol in the Physiological Control of Osteoblast Migration. Int. J. Mol. Sci. 2020, 21, 4661” International Journal of Molecular Sciences doi: 10.3390/ijms21186675 Authors: Lavinia Casati Francesca Pagani Roberto Maggi Francesco Ferrucci Valeria Sibilia Dear Editor,
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6676: Deleterious Alteration of Glia in the Brain of Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21186676 Authors: Eunyoung Kim Undarmaa Otgontenger Ariunzaya Jamsranjav Sang Seong Kim The deterioration of neurons in Alzheimer’s disease (AD) arises from genetic, immunologic, and cellular factors inside the cortex. The traditional consensus of the amyloid-beta (Aβ) paradigm as a singular cause of AD...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6673: Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule—Purkinje Neuron Synaptic Strength International Journal of Molecular Sciences doi: 10.3390/ijms21186673 Authors: Aleksandar Arsović Melanie Vanessa Halbach Júlia Canet-Pons Dilhan Esen-Sehir Claudia Döring Florian Freudenberg Nicoletta Czechowska Kay Seidel Stephan L. Baader Suzana Gispert Nesli-Ece Sen Georg Auburger Spinocerebellar...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6672: Engineered Fragments of the PSMA-Specific 5D3 Antibody and Their Functional Characterization International Journal of Molecular Sciences doi: 10.3390/ijms21186672 Authors: Zora Novakova Nikola Belousova Catherine A. Foss Barbora Havlinova Marketa Gresova Gargi Das Ala Lisok Adam Prada Marketa Barinkova Martin Hubalek Martin G. Pomper Cyril Barinka Prostate-Specific Membrane Antigen (PSMA) is an established biomarker for the...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6668: Therapeutic Effects of Lactoferrin in Ocular Diseases: From Dry Eye Disease to Infections International Journal of Molecular Sciences doi: 10.3390/ijms21186668 Authors: Aldo Vagge Carlotta Senni Federico Bernabei Marco Pellegrini Vincenzo Scorcia Carlo E Traverso Giuseppe Giannaccare Lactoferrin is a naturally occurring iron-binding glycoprotein, produced and secreted by mucosal epithelial cells and neutrophils in various mammalian species,...
Sat Sep 12, 2020 03:00
IJMS, Vol. 21, Pages 6671: Relative and Absolute Quantification of Aberrant and Normal Splice Variants in HBBIVSI−110 (G > A) β-Thalassemia International Journal of Molecular Sciences doi: 10.3390/ijms21186671 Authors: Petros Patsali Panayiota Papasavva Soteroulla Christou Maria Sitarou Michael N. Antoniou Carsten W. Lederer Marina Kleanthous The β-thalassemias are an increasing challenge to health systems worldwide, caused by absent or reduced β-globin...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6669: Interaction Modes of Microsomal Cytochrome P450s with Its Reductase and the Role of Substrate Binding International Journal of Molecular Sciences doi: 10.3390/ijms21186669 Authors: Francisco Esteves Philippe Urban José Rueff Gilles Truan Michel Kranendonk The activity of microsomal cytochromes P450 (CYP) is strictly dependent on the supply of electrons provided by NADPH cytochrome P450 oxidoreductase (CPR). The variant nature of the isoform-specific...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6670: The Role of Tryptophan Metabolites in Musculoskeletal Stem Cell Aging International Journal of Molecular Sciences doi: 10.3390/ijms21186670 Authors: Anaya Bollag Hamrick Isales Although aging is considered a normal process, there are cellular and molecular changes that occur with aging that may be detrimental to health. Osteoporosis is one of the most common age-related degenerative diseases, and its progression correlates with aging and decreased...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6667: Electrophile-Induced Conformational Switch of the Human TRPA1 Ion Channel Detected by Mass Spectrometry International Journal of Molecular Sciences doi: 10.3390/ijms21186667 Authors: Lavanya Moparthi Sven Kjellström Per Kjellbom Milos R. Filipovic Peter M. Zygmunt Urban Johanson The human Transient Receptor Potential A1 (hTRPA1) ion channel, also known as the wasabi receptor, acts as a biosensor of various potentially harmful stimuli. It is activated...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6666: Functional Characterization of Muscarinic Receptors in Human Schwann Cells International Journal of Molecular Sciences doi: 10.3390/ijms21186666 Authors: Roberta Piovesana Alessandro Faroni Ada Maria Tata Adam J. Reid Functional characterization of muscarinic cholinergic receptors in myelinating glial cells has been well described both in central and peripheral nervous system. Rat Schwann cells (SCs) express different muscarinic receptor subtypes with...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6663: MuRF1/TRIM63, Master Regulator of Muscle Mass International Journal of Molecular Sciences doi: 10.3390/ijms21186663 Authors: Dulce Peris-Moreno Daniel Taillandier Cécile Polge The E3 ubiquitin ligase MuRF1/TRIM63 was identified 20 years ago and suspected to play important roles during skeletal muscle atrophy. Since then, numerous studies have been conducted to decipher the roles, molecular mechanisms and regulation of this enzyme. This revealed that MuRF1...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6665: Hedgehog Signaling in Skeletal Development: Roles of Indian Hedgehog and the Mode of Its Action International Journal of Molecular Sciences doi: 10.3390/ijms21186665 Authors: Shinsuke Ohba Hedgehog (Hh) signaling is highly conserved among species and plays indispensable roles in various developmental processes. There are three Hh members in mammals; one of them, Indian hedgehog (Ihh), is expressed in prehypertrophic and hypertrophic chondrocytes during endochondral...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6664: Ameliorative Properties of Boronic Compounds in In Vitro and In Vivo Models of Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21186664 Authors: Panchanan Maiti Jayeeta Manna Zoe N. Burch Denise B. Flaherty Joseph D. Larkin Gary L. Dunbar Alzheimer’s disease (AD) is characterized by amyloid (Aβ) aggregation, hyperphosphorylated tau, neuroinflammation, and severe memory deficits. Reports that...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6661: MALDI-TOF Mass Spectrometry Revealed Significant Lipid Variations in Follicular Fluid and Somatic Follicular Cells but Not in Enclosed Oocytes between the Large Dominant and Small Subordinate Follicles in Bovine Ovary International Journal of Molecular Sciences doi: 10.3390/ijms21186661 Authors: Priscila Silvana Bertevello Ana-Paula Teixeira-Gomes Valerie Labas Luiz Cordeiro Marie-Claire Blache Pascal Papillier Galina Singina Rustem Uzbekov Virginie...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6660: The brlA Gene Deletion Reveals That Patulin Biosynthesis Is Not Related to Conidiation in Penicillium expansum International Journal of Molecular Sciences doi: 10.3390/ijms21186660 Authors: Chrystian Zetina-Serrano Ophélie Rocher Claire Naylies Yannick Lippi Isabelle P. Oswald Sophie Lorber Olivier Puel Dissemination and survival of ascomycetes is through asexual spores. The brlA gene encodes a C2H2-type zinc-finger transcription factor, which...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6662: Altered Secretome and ROS Production in Olfactory Mucosa Stem Cells Derived from Friedreich’s Ataxia Patients International Journal of Molecular Sciences doi: 10.3390/ijms21186662 Authors: Sara Pérez-Luz Frida Loria Yurika Katsu-Jiménez Daniel Oberdoerfer Oscar-Li Yang Filip Lim José Luis Muñoz-Blanco Javier Díaz-Nido Friedreich’s ataxia is the most common hereditary ataxia for which there is no cure or approved treatment at present....
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6658: Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology International Journal of Molecular Sciences doi: 10.3390/ijms21186658 Authors: Athina A. Kyriazi Efstathios Papiris Konstantinos Kitsos Kalyvianakis George Sakellaris Stavroula Baritaki The identification of cancer stem cells (CSCs) as initiators of carcinogenesis has revolutionized the era of cancer research and our perception for the disease treatment options. Additional CSC...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6654: Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs) International Journal of Molecular Sciences doi: 10.3390/ijms21186654 Authors: Stephen Safe Un-ho Jin Hyejin Park Robert S. Chapkin Arul Jayaraman The aryl hydrocarbon receptor (AhR) was first identified as the intracellular protein that bound and mediated the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and dioxin-like compounds (DLCs). Subsequent...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6659: A Novel Role of Interleukin-6 as a Regulatory Factor of Inflammation-Associated Deterioration in Osteoblast Arrangement International Journal of Molecular Sciences doi: 10.3390/ijms21186659 Authors: Aira Matsugaki Shun Matsumoto Takayoshi Nakano Inflammatory disorders are associated with bone destruction; that is, deterioration in bone cell activities are under the control of the innate immune system. Macrophages play a central role in innate immunity...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6656: Minor Ginsenoside Rg2 and Rh1 Attenuates LPS-Induced Acute Liver and Kidney Damages via Downregulating Activation of TLR4-STAT1 and Inflammatory Cytokine Production in Macrophages International Journal of Molecular Sciences doi: 10.3390/ijms21186656 Authors: Diem Thi Ngoc Huynh Naehwan Baek Sohyun Sim Chang-Seon Myung Kyung-Sun Heo Ginsenosides have been reported to have various biological effects, such as immune regulation and anticancer activity....
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6657: Editorial: Special Issue on “Therapeutic Approaches for Cystic Fibrosis” International Journal of Molecular Sciences doi: 10.3390/ijms21186657 Authors: Nicoletta Pedemonte Cystic fibrosis (CF) is the most common lethal genetic disease in Caucasian populations, occurring in approximately 1 in 3000 newborns worldwide [...]
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6653: Adult Neurogenesis in the Drosophila Brain: The Evidence and the Void International Journal of Molecular Sciences doi: 10.3390/ijms21186653 Authors: Guiyi Li Alicia Hidalgo Establishing the existence and extent of neurogenesis in the adult brain throughout the animals including humans, would transform our understanding of how the brain works, and how to tackle brain damage and disease. Obtaining convincing, indisputable experimental evidence has generally...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6652: Identification of Gastritis Subtypes by Convolutional Neuronal Networks on Histological Images of Antrum and Corpus Biopsies International Journal of Molecular Sciences doi: 10.3390/ijms21186652 Authors: Georg Steinbuss Katharina Kriegsmann Mark Kriegsmann Background: Gastritis is a prevalent disease and commonly classified into autoimmune (A), bacterial (B), and chemical (C) type gastritis. While the former two subtypes are associated with an increased...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6655: Pathological Responses of Cardiac Mitochondria to Burn Trauma International Journal of Molecular Sciences doi: 10.3390/ijms21186655 Authors: Meijing Wang Susan R. Scott Leonidas G. Koniaris Teresa A. Zimmers Despite advances in treatment and care, burn trauma remains the fourth most common type of traumatic injury. Burn-induced cardiac failure is a key factor for patient mortality, especially during the initial post-burn period (the first 24 to 48...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6651: Facts about Fats: New Insights into the Role of Lipids in Metabolism, Disease and Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21186651 Authors: Marco Segatto Valentina Pallottini Although initially regarded as a passive system to store energy, lipids are now considered to play crucial, structural and functional roles in almost all the biological processes involved in the regulation of physiological and pathological conditions [...]
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6648: mRNA Post-Transcriptional Regulation by AU-Rich Element-Binding Proteins in Liver Inflammation and Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21186648 Authors: Dobrochna Dolicka Cyril Sobolewski Marta Correia de Sousa Monika Gjorgjieva Michelangelo Foti AU-rich element-binding proteins (AUBPs) represent important post-transcriptional regulators of gene expression. AUBPs can bind to the AU-rich elements present in the 3’-UTR...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6650: Ionizing Radiation and Translation Control: A Link to Radiation Hormesis?
IJMS, Vol. 21, Pages 6650: Ionizing Radiation and Translation Control: A Link to Radiation Hormesis? International Journal of Molecular Sciences doi: 10.3390/ijms21186650 Authors: Usha Kabilan Tyson E. Graber Tommy Alain Dmitry Klokov Protein synthesis, or mRNA translation, is one of the most energy-consuming functions in cells. Translation of mRNA into proteins is thus highly regulated by and integrated with upstream and downstream signaling pathways, dependent on various transacting...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6649: Flying Together: Drosophila as a Tool to Understand the Genetics of Human Alcoholism International Journal of Molecular Sciences doi: 10.3390/ijms21186649 Authors: Daniel R. Lathen Collin B. Merrill Adrian Rothenfluh Alcohol use disorder (AUD) exacts an immense toll on individuals, families, and society. Genetic factors determine up to 60% of an individual’s risk of developing problematic alcohol habits. Effective AUD prevention and treatment...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6646: Milk Exosomes: Perspective Agents for Anticancer Drug Delivery International Journal of Molecular Sciences doi: 10.3390/ijms21186646 Authors: Sergey Sedykh Anna Kuleshova Georgy Nevinsky Exosomes are biological nanovesicles that participate in intercellular communication by transferring biologically active chemical compounds (proteins, microRNA, mRNA, DNA, and others). Due to their small size (diameter 40–100 nm) and high biological compatibility,...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6647: An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy International Journal of Molecular Sciences doi: 10.3390/ijms21186647 Authors: Eloise Keeling Annabelle J. Culling David A. Johnston David S. Chatelet Anton Page David A. Tumbarello Andrew J. Lotery J. Arjuna Ratnayaka Impaired cargo trafficking and the aggregation of intracellular macromolecules are key features of...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6644: The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders International Journal of Molecular Sciences doi: 10.3390/ijms21186644 Authors: Izabela Szymczak-Pajor Józef Drzewoski Agnieszka Śliwińska Numerous studies have shown that vitamin D deficiency is very common in modern societies and is perceived as an important risk factor in the development of insulin resistance and related diseases such as obesity and type...
Fri Sep 11, 2020 03:00
IJMS, Vol. 21, Pages 6645: AAA+ Molecular Chaperone ClpB in Leptospira interrogans: Its Role and Significance in Leptospiral Virulence and Pathogenesis of Leptospirosis International Journal of Molecular Sciences doi: 10.3390/ijms21186645 Authors: Sabina Kędzierska-Mieszkowska Zbigniew Arent Bacterial ClpB is an ATP-dependent disaggregase that belongs to the Hsp100/Clp subfamily of the AAA+ ATPases and cooperates with the DnaK chaperone system in the reactivation of aggregated proteins,...
Fri Sep 11, 2020 03:00
JCM, Vol. 9, Pages 2962: Analysis of Tuberculosis Meningitis Pathogenesis, Diagnosis, and Treatment Journal of Clinical Medicine doi: 10.3390/jcm9092962 Authors: Aysha Arshad Sujay Dayal Raj Gadhe Ajinkya Mawley Kevin Shin Daniel Tellez Phong Phan Vishwanath Venketaraman Tuberculosis (TB) is the most prevalent infectious disease in the world. In recent years there has been a significant increase in the incidence of TB due to the emergence of multidrug resistant strains...
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JCM, Vol. 9, Pages 2961: Colchicine to Weather the Cytokine Storm in Hospitalized Patients with COVID-19 Journal of Clinical Medicine doi: 10.3390/jcm9092961 Authors: Luigi Brunetti Oumou Diawara Andrew Tsai Bonnie L. Firestein Ronald G. Nahass George Poiani Naomi Schlesinger The repurposing of colchicine for the treatment of COVID-19 was suggested based in its immunomodulatory, anti-inflammatory, and anti-viral properties. We performed a single-center propensity score...
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JCM, Vol. 9, Pages 2960: The Prognostic Model of Pre-Treatment Complete Blood Count (CBC) for Recurrence in Early Cervical Cancer Journal of Clinical Medicine doi: 10.3390/jcm9092960 Authors: Joseph J. Noh Myong Cheol Lim Moon-Hong Kim Yun Hwan Kim Eun Seop Song Seok Ju Seong Dong Hoon Suh Jong-Min Lee Chulmin Lee Chel Hun Choi The aim of the present study was to investigate the prognostic role of the pre-treatment complete blood count (CBC) profile as a predictive...
Sun Sep 13, 2020 03:00
JCM, Vol. 9, Pages 2959: Comparison of Postoperative Renal Function between Non-Steroidal Anti-Inflammatory Drug and Opioids for Patient-Controlled Analgesia after Laparoscopic Nephrectomy: A Retrospective Cohort Study Journal of Clinical Medicine doi: 10.3390/jcm9092959 Authors: Jiwon Han Young-Tae Jeon Ah-Young Oh Chang-Hoon Koo Yu Kyung Bae Jung-Hee Ryu Non-steroidal anti-inflammatory drugs (NSAIDs) can be used as opioid alternatives for patient-controlled analgesia...
Sun Sep 13, 2020 03:00
JCM, Vol. 9, Pages 2958: Cystatin C, a Controversial Biomarker in Hypothyroid Patients under Levothyroxine Therapy: THYRenal, a Pilot Cohort Observational Study Journal of Clinical Medicine doi: 10.3390/jcm9092958 Authors: Marta Greco Daniela Patrizia Foti Antonio Aversa Giorgio Fuiano Antonio Brunetti Mariadelina Simeoni Background: Cystatin C (Cys-C) is recognized as one of the most reliable renal function parameters in the general population, although it might be biased...
Sun Sep 13, 2020 03:00
JCM, Vol. 9, Pages 2957: B-Type Natriuretic Peptide as Biomarker of COVID-19 Disease Severity—A Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9092957 Authors: Sabato Sorrentino Michele Cacia Isabella Leo Alberto Polimeni Jolanda Sabatino Carmen Anna Maria Spaccarotella Annalisa Mongiardo Salvatore De Rosa Ciro Indolfi Up to 15% of coronavirus disease 2019 (COVID-19) patients experience severe clinical presentation, resulting in acute respiratory distress...
Sat Sep 12, 2020 03:00
JCM, Vol. 9, Pages 2956: No-Reflow after PPCI—A Predictor of Short-Term Outcomes in STEMI Patients Journal of Clinical Medicine doi: 10.3390/jcm9092956 Authors: Larisa Renata Pantea-Roșan Vlad Alin Pantea Simona Bungau Delia Mirela Tit Tapan Behl Cosmin Mihai Vesa Cristiana Bustea Radu Dumitru Moleriu Marius Rus Mircea Ioachim Popescu Vladiana Turi Camelia Cristina Diaconu The no-reflow phenomenon following primary percutaneous coronary intervention (PPCI)...
Sat Sep 12, 2020 03:00
JCM, Vol. 9, Pages 2955: Optimized Identification of Advanced Chronic Kidney Disease and Absence of Kidney Disease by Combining Different Electronic Health Data Resources and by Applying Machine Learning Strategies Journal of Clinical Medicine doi: 10.3390/jcm9092955 Authors: Christoph Weber Lena Röschke Luise Modersohn Christina Lohr Tobias Kolditz Udo Hahn Danny Ammon Boris Betz Michael Kiehntopf Automated identification of advanced chronic kidney disease (CKD...
Sat Sep 12, 2020 03:00
JCM, Vol. 9, Pages 2951: Neurophysiology and Psychopathology Underlying PTSD and Recent Insights into the PTSD Therapies—A Comprehensive Review Journal of Clinical Medicine doi: 10.3390/jcm9092951 Authors: Gjumrakch Aliev Narasimha M. Beeraka Vladimir N. Nikolenko Andrey A. Svistunov Tatyana Rozhnova Svetlana Kostyuk Igor Cherkesov Liliya V. Gavryushova Andrey A. Chekhonatsky Liudmila M. Mikhaleva Siva G. Somasundaram Marco F. Avila-Rodriguez Cecil E. Kirkland...
Sat Sep 12, 2020 03:00
JCM, Vol. 9, Pages 2953: Long-Term Safety of Endoscopic Biliary Stents for Cholangitis Complicating Choledocholithiasis: A Multi-Center Study Journal of Clinical Medicine doi: 10.3390/jcm9092953 Authors: Wisam Sbeit Tawfik Khoury Anas Kadah Dan M. Livovsky Adi Nubani Amir Mari Eran Goldin Mahmud Mahamid Background: Treatment of cholangitis complicating choledocholithiasis includes biliary sphincterotomy and stone extraction. In certain cases of elderly comorbid patients...
Sat Sep 12, 2020 03:00
JCM, Vol. 9, Pages 2954: Blood Pressure and Body Weight Have Different Effects on Pulse Wave Velocity and Cardiac Mass in Children Journal of Clinical Medicine doi: 10.3390/jcm9092954 Authors: Simonetta Genovesi Paolo Salvi Elisa Nava Elena Tassistro Marco Giussani Ilaria Desimone Antonina Orlando Mariagrazia Battaglino Giulia Lieti Massimo Montemerlo Laura Antolini Gianfranco Parati Background: High blood pressure (BP) and excess weight can lead to early...
Sat Sep 12, 2020 03:00
JCM, Vol. 9, Pages 2949: Effect of a Combination of Myo-Inositol, Alpha-Lipoic Acid, and Folic Acid on Oocyte Morphology and Embryo Morphokinetics in non-PCOS Overweight/Obese Patients Undergoing IVF: A Pilot, Prospective, Randomized Study Journal of Clinical Medicine doi: 10.3390/jcm9092949 Authors: Stefano Canosa Carlotta Paschero Andrea Carosso Sara Leoncini Noemi Mercaldo Gianluca Gennarelli Chiara Benedetto Alberto Revelli Herein we aimed at assessing whether...
Sat Sep 12, 2020 03:00
JCM, Vol. 9, Pages 2950: The Wide Spectrum of COVID-19 Clinical Presentation in Children Journal of Clinical Medicine doi: 10.3390/jcm9092950 Authors: Nadia Nathan Blandine Prevost Chiara Sileo Nicolas Richard Laura Berdah Guillaume Thouvenin Guillaume Aubertin Thibault Lecarpentier Aurélie Schnuriger Julien Jegard Isabelle Guellec Jessica Taytard Harriet Corvol Background: Ten months after its appearance in December 2019, SARS-CoV-2 has infected more...
Sat Sep 12, 2020 03:00
JCM, Vol. 9, Pages 2952: Perinatal Predictors of Postpartum Depression: Results of a Retrospective Comparative Study Journal of Clinical Medicine doi: 10.3390/jcm9092952 Authors: Jolanta Banasiewicz Kornelia Zaręba Małgorzata Bińkowska Hanna Rozenek Stanisław Wójtowicz Grzegorz Jakiel Postpartum mood disorders occur in a considerable number of women with the most common postpartum disorder being baby blues. The study aimed at the identification of the risk factors present...
Sat Sep 12, 2020 03:00
JCM, Vol. 9, Pages 2947: Selective Apheresis of C-Reactive Protein for Treatment of Indications with Elevated CRP Concentrations Journal of Clinical Medicine doi: 10.3390/jcm9092947 Authors: Stefan Kayser Patrizia Brunner Katharina Althaus Johannes Dorst Ahmed Sheriff Almost every kind of inflammation in the human body is accompanied by rising C-reactive protein (CRP) concentrations. This can include bacterial and viral infection, chronic inflammation and so-called sterile...
Sat Sep 12, 2020 03:00
JCM, Vol. 9, Pages 2948: Risk Stratification for Patients with Chest Pain Discharged Home from the Emergency Department Journal of Clinical Medicine doi: 10.3390/jcm9092948 Authors: Peter A. Kavsak Joshua O. Cerasuolo Shawn E. Mondoux Jonathan Sherbino Jinhui Ma Brock K. Hoard Richard Perez Hsien Seow Dennis T. Ko Andrew Worster For patients with chest pain who are deemed clinically to be low risk and discharged home from the emergency department (ED), it is...
Sat Sep 12, 2020 03:00
JCM, Vol. 9, Pages 2946: Care Dependency in Non-Hospitalized Patients with COVID-19 Journal of Clinical Medicine doi: 10.3390/jcm9092946 Authors: Anouk W. Vaes Felipe V.C. Machado Roy Meys Jeannet M. Delbressine Yvonne M.J. Goertz Maarten Van Herck Sarah Houben-Wilke Frits M.E. Franssen Herman Vijlbrief Yvonne Spies Alex J. Van ’t Hul Chris Burtin Daisy J.A. Janssen Martijn A. Spruit Background: A large sample of “mild” COVID-19...
Sat Sep 12, 2020 03:00
JCM, Vol. 9, Pages 2945: Microbial Analysis of Saliva to Identify Oral Diseases Using a Point-of-Care Compatible qPCR Assay Journal of Clinical Medicine doi: 10.3390/jcm9092945 Authors: Pune N. Paqué Christopher Herz Joël S. Jenzer Daniel B. Wiedemeier Thomas Attin Nagihan Bostanci Georgios N. Belibasakis Kai Bao Philipp Körner Tanja Fritz Julia Prinz Patrick R. Schmidlin Thomas Thurnheer Florian J. Wegehaupt Konstantinos Mitsakakis Johannes R....
Fri Sep 11, 2020 03:00
JCM, Vol. 9, Pages 2944: Prevalence of Novel Myositis Autoantibodies in a Large Cohort of Patients with Interstitial Lung Disease Journal of Clinical Medicine doi: 10.3390/jcm9092944 Authors: Sofia A. Moll Mark G.J.P. Platenburg Anouk C.M. Platteel Adriane D.M. Vorselaars Montse Janssen Bonàs Claudia Roodenburg-Benschop Bob Meek Coline H.M. van Moorsel Jan C. Grutters Connective tissue diseases (CTDs) are an important secondary cause of interstitial lung disease...
Fri Sep 11, 2020 03:00
JCM, Vol. 9, Pages 2943: The Efficacy of the Mineralcorticoid Receptor Antagonist Canrenone in COVID-19 Patients Journal of Clinical Medicine doi: 10.3390/jcm9092943 Authors: Marco Vicenzi Massimiliano Ruscica Simona Iodice Irene Rota Angelo Ratti Roberta Di Cosola Alberto Corsini Valentina Bollati Stefano Aliberti Francesco Blasi Background: In COVID-19 patients, aldosterone via angiotensin-converting enzyme-2 deregulation may be responsible for systemic and...
Fri Sep 11, 2020 03:00
JCM, Vol. 9, Pages 2942: Neutrophil Extracellular Traps and By-Products Play a Key Role in COVID-19: Pathogenesis, Risk Factors, and Therapy Journal of Clinical Medicine doi: 10.3390/jcm9092942 Authors: Alain R. Thierry Benoit Roch Understanding of the pathogenesis of the coronavirus disease-2019 (COVID-19) remains incomplete, particularly in respect to the multi-organ dysfunction it may cause. We were the first to report the analogous biological and physiological features of COVID-19...
Fri Sep 11, 2020 03:00
JCM, Vol. 9, Pages 2939: Nitric Oxide Stroke Volume Index as a New Hemodynamic Prognostic Parameter for Patients with Pulmonary Arterial Hypertension Journal of Clinical Medicine doi: 10.3390/jcm9092939 Authors: Karolina Barańska-Pawełczak Celina Wojciechowska Mariusz Opara Wojciech Jacheć The aim of the study was to determine the prognostic value of hemodynamic parameters measured during initial diagnostic right heart catheterization (RHC) in standard conditions and using a...
Fri Sep 11, 2020 03:00
JCM, Vol. 9, Pages 2941: Timing of Osteoporotic Vertebral Fractures in Lung and Heart Transplantation: A Longitudinal Study Journal of Clinical Medicine doi: 10.3390/jcm9092941 Authors: Carla Caffarelli Maria D. Tomai Pitinca Mario Alessandri Paolo Cameli Elena Bargagli David Bennett Antonella Fossi Sonia Bernazzali Stefano Gonnelli Bone loss and bone fractures are common complications after organ transplantation. Many factors contribute to the pathogenesis of...
Fri Sep 11, 2020 03:00
JCM, Vol. 9, Pages 2940: Longitudinal Evaluation of Working Memory in Duchenne Muscular Dystrophy Journal of Clinical Medicine doi: 10.3390/jcm9092940 Authors: Thangarajh Elfring Trifillis Objective: The developmental maturation of forward and backward digit spans—indices of working memory—in boys with nonsense (nm) Duchenne muscular dystrophy (DMD) (nmDMD) was assessed using prospective, longitudinal data. Methods: Fifty-five boys of the 57 subjects with...
Fri Sep 11, 2020 03:00
JCM, Vol. 9, Pages 2936: The Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms (rs3063368, rs755622) Predict Acute Kidney Injury and Death after Cardiac Surgery Journal of Clinical Medicine doi: 10.3390/jcm9092936 Authors: Luisa Averdunk Jürgen Bernhagen Karl Fehnle Harald Surowy Hermann-Josef Lüdecke Sören Mucha Patrick Meybohm Dagmar Wieczorek Lin Leng Gernot Marx David E. Leaf Alexander Zarbock Kai Zacharowski on behalf of the RIPHeart...
Fri Sep 11, 2020 03:00
JCM, Vol. 9, Pages 2937: Autism and COVID-19: A Case Series in a Neurodevelopmental Unit Journal of Clinical Medicine doi: 10.3390/jcm9092937 Authors: Leslie Nollace Cora Cravero Alice Abbou Brice Mazda-Walter Alexandre Bleibtreu Nathalie Pereirra Myriam Sainte-Marie David Cohen Marianna Giannitelli Background: COVID-19 has become pandemic and can impact individuals with autism as well. Here, we report a case series admitted to a neurobehavioral unit dedicated...
Fri Sep 11, 2020 03:00
JCM, Vol. 9, Pages 2938: Etiology of Ischemic Strokes of Patients with Atrial Fibrillation and Therapy with Anticoagulants Journal of Clinical Medicine doi: 10.3390/jcm9092938 Authors: Jan C. Purrucker Kyra Hölscher Jennifer Kollmer Peter A. Ringleb Background: Reducing the number of ischemic strokes in patients with atrial fibrillation despite oral anticoagulation remains an important, yet largely unsolved challenge. Therefore, we assessed the etiology of ischemic strokes despite...
Fri Sep 11, 2020 03:00
JCM, Vol. 9, Pages 2935: Repurposing Immunomodulatory Therapies against Coronavirus Disease 2019 (COVID-19) in the Era of Cardiac Vigilance: A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9092935 Authors: Courtney M. Campbell Avirup Guha Tamanna Haque Tomas G. Neilan Daniel Addison The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in efforts to identify therapies to ameliorate adverse clinical outcomes. The recognition of the key role...
Fri Sep 11, 2020 03:00
JCM, Vol. 9, Pages 2933: Shortcomings of Trials Assessing Antidepressants in the Management of Irritable Bowel Syndrome: A Critical Review Journal of Clinical Medicine doi: 10.3390/jcm9092933 Authors: Sun Jung Oh Will Takakura Ali Rezaie Irritable bowel syndrome (IBS) is a common disorder requiring complex, multidisciplinary management. Antidepressants are commonly used and recommended in guidelines for the treatment of patients with IBS. We assessed randomized controlled trials...
Fri Sep 11, 2020 03:00
JCM, Vol. 9, Pages 2934: Targeting PI3K/Akt/mTOR in AML: Rationale and Clinical Evidence Journal of Clinical Medicine doi: 10.3390/jcm9092934 Authors: Salihanur Darici Hazem Alkhaldi Gillian Horne Heather G. Jørgensen Sandra Marmiroli Xu Huang Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy characterized by excessive proliferation and accumulation of immature myeloid blasts in the bone marrow. AML has a very poor 5-year survival rate of...
Fri Sep 11, 2020 03:00
JCM, Vol. 9, Pages 2931: Assessing the Relationship between Sense of Agency, the Bodily-Self and Stress: Four Virtual-Reality Experiments in Healthy Individuals Journal of Clinical Medicine doi: 10.3390/jcm9092931 Authors: Yonatan Stern Danny Koren Renana Moebus Gabriella Panishev Roy Salomon The bodily-self, our experience of being a body, arises from the interaction of several processes. For example, embodied Sense of Agency (SoA), the feeling of controlling our body’s...
Fri Sep 11, 2020 03:00
JCM, Vol. 9, Pages 2932: Six-Month Predictive Value of Diuretic Resistance Formulas in Discharged Heart Failure Patients after an Acute Decompensation Journal of Clinical Medicine doi: 10.3390/jcm9092932 Authors: Mauro Feola Arianna Rossi Marzia Testa Cinzia Ferreri Alberto Palazzuoli Guido Pastorini Gaetano Ruocco Background. The diuretic response has been shown to be a robust independent marker of cardiovascular outcomes in acute heart failure patients. The objectives...
Fri Sep 11, 2020 03:00
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