UAE1 inhibition mediates the unfolded protein response, DNA damage and caspase-dependent cell death in pancreatic cancer. Transl Oncol. 2020 Jul 17;13(11):100834 Authors: Liu Y, Awadia S, Delaney A, Sitto M, Engelke C, Patel H, Calcaterra A, Zelenka-Wang S, Lee H, Contessa J, Neamati N, Ljungman M, Lawrence TS, Morgan MA, Rehemtulla A Abstract The Unfolded Protein Response (UPR) plays a key role in the adaptive response to loss of protein homeostasis...
Tue Jul 21, 2020 13:04
Pathology Data Set for Reporting Parathyroid Carcinoma & Atypical Parathyroid Neoplasm: Recommendations from the International Collaboration on Cancer Reporting (ICCR). Hum Pathol. 2020 Jul 17;: Authors: Williams MD, DeLellis RA, Erickson LA, Gupta R, Johnson SJ, Kameyama K, Natu S, Ng T, Perren A, Perrier ND, Seethala RR, Gill AJ Abstract BACKGROUND AND OBJECTIVES: Standardized pathologic reporting for cancers improves patient care and...
Tue Jul 21, 2020 13:04
The m6A methylation regulator-based signature for predicting the prognosis of prostate cancer. Future Oncol. 2020 Jul 20;: Authors: Wang J, Lin H, Zhou M, Xiang Q, Deng Y, Luo L, Liu Y, Zhu Z, Zhao Z Abstract Aim: To construct a survival prediction signature for prostate cancer (PC) based on the RNA N6-methyladenosine (m6A) methylation regulator. Materials & methods: This paper explores the interaction network of differentially expressed...
Tue Jul 21, 2020 13:04
Cancer-associated fibroblasts of colorectal cancer and their markers: updates, challenges and translational outlook. Future Oncol. 2020 Jul 20;: Authors: Musa M, Ali A Abstract Accumulation of cancer-associated fibroblasts (CAFs) in the tumor microenvironment is associated with poor prognosis and recurrence of colorectal cancer (CRC). Despite their prominent roles in colorectal carcinogenesis, there is a lack of robust and specific markers...
Tue Jul 21, 2020 13:04
Genome-Wide Somatic Alterations in Multiple Myeloma Reveal a Superior Outcome Group. J Clin Oncol. 2020 Jul 20;:JCO2000461 Authors: Samur MK, Aktas Samur A, Fulciniti M, Szalat R, Han T, Shammas M, Richardson P, Magrangeas F, Minvielle S, Corre J, Moreau P, Thakurta A, Anderson KC, Parmigiani G, Avet-Loiseau H, Munshi NC Abstract PURPOSE: Multiple myeloma (MM) is accompanied by heterogeneous somatic alterations. The overall goal of this study...
Tue Jul 21, 2020 13:04
Effects of tumor types on treatment strategy formulation and prognostic evaluation of gastric neuroendocrine tumors. Future Oncol. 2020 Jul 20;: Authors: Jiao X, Wang Z, Peng X, Zhang L, Zhou L Abstract Aim: The effects of different types of gastric neuroendocrine tumors (G-NETs) on treatment strategy formulation and prognostic evaluation still remain controversial due to their rarity. Methods: 187 patients diagnosed with G-NETs were subdivided...
Tue Jul 21, 2020 13:04
Atypical patterns of response and progression in the era of immunotherapy combinations. Future Oncol. 2020 Jul 20;: Authors: Ferrara R, Matos I Abstract In the immunoncology era, an acceleration of tumor growth upon immune checkpoint inhibitors (ICI), defined as hyperprogressive disease (HPD) has been observed across different cancers. Although in non-small-cell lung cancer, most of the available evidence regarding HPD has been reported for...
Tue Jul 21, 2020 13:04
Prognostic role of targeted therapy in patients with multiple-site metastases from non-small- cell lung cancer. Future Oncol. 2020 Jul 20;: Authors: Meng C, Ge X, Tian J, Wei J, Zhao L Abstract Aim: To evaluate the prognostic role of EGFR mutations in patients with multi-site metastases from non-small-cell lung cancer (NSCLC). Patients & methods: A total of 215 advanced NSCLC patients with multi-site metastases were included. The overall...
Tue Jul 21, 2020 13:04
Pediatric low grade focal brainstem glioma: outcomes of different treatment strategies and prognostic factors. Future Oncol. 2020 Jul 20;: Authors: Elmaraghi C, Bishr MK, Mousa AG, Ahmed S, Refaat A, Elhemaly A, Ayadi ME, Taha H, Maher E, Elbeltagy M, Zaghloul MS Abstract Background: This study explores the prognostic factors and outcomes of different treatment modalities in focal brain stem glioma (FBSG). Materials & methods: Pediatric...
Tue Jul 21, 2020 13:04
Related Articles Modeling precision genomic-based radiation dose response in rectal cancer. Future Oncol. 2020 Jul 20;: Authors: Yuan Z, Frazer M, Ahmed KA, Naqvi SMH, Schell MJ, Felder S, Sanchez J, Dessureault S, Imanirad I, Kim RD, Torres-Roca JF, Hoffe SE, Frakes JM Abstract Aim: Genomic-based risk stratification to personalize radiation dose in rectal cancer. Patients & methods: We modeled genomic-based radiation dose response using...
Tue Jul 21, 2020 13:04
Related Articles Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis. Elife. 2020 Jul 20;9: Authors: Nassar ZD, Mah CY, Dehairs J, Burvenich IJ, Irani S, Centenera MM, Helm M, Shrestha RK, Moldovan M, Don AS, Holst J, Scott AM, Horvath LG, Lynn DJ, Selth LA, Hoy AJ, Swinnen JV, Butler LM Abstract Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human...
Tue Jul 21, 2020 13:04
Related Articles "Living life as if I never had cancer": A study of the meaning of living well in adolescents and young adults who have experienced cancer. Pediatr Blood Cancer. 2020 Jul 19;:e28599 Authors: Schreiner K, Grossoehme DH, Friebert S, Baker JN, Needle J, Lyon ME Abstract BACKGROUND: Cancer diagnoses pose challenges to adolescents' and young adults' (AYA) physical, mental, and emotional health, and developmental tasks. In order for...
Tue Jul 21, 2020 13:04
Related Articles Detection of somatic TP53 mutation in surgically resected small-cell lung cancer by targeted exome sequencing: association with longer relapse-free survival. Heliyon. 2020 Jul;6(7):e04439 Authors: Yokouchi H, Nishihara H, Harada T, Yamazaki S, Kikuchi H, Oizumi S, Uramoto H, Tanaka F, Harada M, Akie K, Sugaya F, Fujita Y, Takamura K, Kojima T, Higuchi M, Honjo O, Minami Y, Watanabe N, Nishimura M, Suzuki H, Dosaka-Akita H, Isobe H Abstract...
Tue Jul 21, 2020 13:04
Related Articles Identification of Differentially Expressed lncRNAs and mRNAs in Children with Acquired Aplastic Anemia by RNA Sequencing. Biomed Res Int. 2020;2020:8962090 Authors: Lu S, Song X, Chen J, Qiao X Abstract Background: The effects of long noncoding RNAs (lncRNAs) and their related messenger RNAs (mRNAs) remain unknown in children with acquired aplastic anemia (AA). The aim of this study is to screen key lncRNAs and mRNAs and investigate...
Tue Jul 21, 2020 13:04
Related Articles Clinical Impact of Breast Cancer Stem Cells in Metastatic Breast Cancer Patients. J Oncol. 2020;2020:2561726 Authors: Elbaiomy MA, Akl T, Atwan N, Elsayed AA, Elzaafarany M, Shamaa S Abstract Background: Breast tumors are composed of phenotypically diverse groups of cells; however, it is unclear which of these cells contribute to tumor development. Breast cancer management usually targets proliferating cells, but as breast cancer...
Tue Jul 21, 2020 13:04
Related Articles Biliary Drainage Before and After Liver Resection for Perihilar Cholangiocarcinoma. Am Surg. 2020 Jun;86(6):628-634 Authors: Enomoto LM, Dixon MEB, Burdette A, Gusani NJ Abstract Perihilar cholangiocarcinoma (PHC) is a rare tumor that requires surgical resection for a potential cure. The role of preoperative biliary drainage has long been debated, given its treatment of biliary sepsis and decompression of the future liver remnant...
Tue Jul 21, 2020 13:04
Related Articles The increasing value of eHealth in the delivery of patient-centred cancer care. Lancet Oncol. 2020 05;21(5):e240-e251 Authors: Penedo FJ, Oswald LB, Kronenfeld JP, Garcia SF, Cella D, Yanez B Abstract The increasing use of eHealth has ushered in a new era of patient-centred cancer care that moves beyond the traditional in-person care model to real-time, dynamic, and technology-assisted assessments and interventions. eHealth...
Tue Jul 21, 2020 13:04
Related Articles Radiotheranostics: a roadmap for future development. Lancet Oncol. 2020 03;21(3):e146-e156 Authors: Herrmann K, Schwaiger M, Lewis JS, Solomon SB, McNeil BJ, Baumann M, Gambhir SS, Hricak H, Weissleder R Abstract Radiotheranostics, injectable radiopharmaceuticals with antitumour effects, have seen rapid development over the past decade. Although some formulations are already approved for human use, more radiopharmaceuticals...
Tue Jul 21, 2020 13:04
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.