Cancers, Vol. 12, Pages 1990: Immunotherapy for Early Stage Colorectal Cancer: A Glance into the Future Cancers doi: 10.3390/cancers12071990 Authors: Romain Cohen Qian Shi Thierry André Immune checkpoint inhibitors (ICI) have reshaped therapeutic strategies for cancer patients. The development of ICI for early stage colorectal cancer is accompanied by specific challenges: (i) the selection of patients who are likely to benefit from these treatments, i.e., patients with tumors harboring...
Tue Jul 21, 2020 03:00
Cancers, Vol. 12, Pages 1988: Systemic Treatment Selection for Patients with Advanced Pancreatic Neuroendocrine Tumours (PanNETs) Cancers doi: 10.3390/cancers12071988 Authors: Vera G. Megdanova-Chipeva Angela Lamarca Alison Backen Mairéad G. McNamara Jorge Barriuso Sonia Sergieva Lilia Gocheva Was Mansoor Prakash Manoharan Juan W. Valle Pancreatic neuroendocrine tumours (PanNETs) are rare diseases and a good example of how research is not only feasible, but...
Tue Jul 21, 2020 03:00
Cancers, Vol. 12, Pages 1993: Plasma Treatment Limits Cutaneous Squamous Cell Carcinoma Development In Vitro and In Vivo Cancers doi: 10.3390/cancers12071993 Authors: Gabriella Pasqual-Melo Thiago Nascimento Larissa Juliani Sanches Fernanda Paschoal Blegniski Julya Karen Bianchi Sanjeev Kumar Sagwal Julia Berner Anke Schmidt Steffen Emmert Klaus-Dieter Weltmann Thomas von Woedtke Rajesh Kumar Gandhirajan Alessandra Lourenço Cecchini Sander Bekeschus ...
Tue Jul 21, 2020 03:00
Cancers, Vol. 12, Pages 1987: Tumor-Associated Macrophage Status in Cancer Treatment Cancers doi: 10.3390/cancers12071987 Authors: Anna Maria Malfitano Simona Pisanti Fabiana Napolitano Sarah Di Somma Rosanna Martinelli Giuseppe Portella Tumor-associated macrophages (TAMs) represent the most abundant innate immune cells in tumors. TAMs, exhibiting anti-inflammatory phenotype, are key players in cancer progression, metastasis and resistance to therapy. A high TAM infiltration...
Tue Jul 21, 2020 03:00
Cancers, Vol. 12, Pages 1984: Impact of Eukaryotic Translation Initiation Factors on Breast Cancer: Still Much to Investigate Cancers doi: 10.3390/cancers12071984 Authors: Qin Chen Bo Yang Norbert Nass Christoph Schatz Johannes Haybaeck Breast carcinoma (BC) remains one of the most serious health problems. It is a heterogeneous entity, and mainly classified according to receptor status for estrogen (ER), progesterone (PR) and egf (HER2/Neu), as well as the proliferation marker...
Tue Jul 21, 2020 03:00
Cancers, Vol. 12, Pages 1986: Hypoalbuminemia Reflects Nutritional Risk, Body Composition and Systemic Inflammation and is Independently Associated with Survival in Patients with Colorectal Cancer Cancers doi: 10.3390/cancers12071986 Authors: Arwa S. Almasaudi Ross D. Dolan Christine A. Edwards Donald C. McMillan It has long been recognized that albumin has prognostic value in patients with cancer. However, although the Global Leadership Initiative on Malnutrition GLIM criteria...
Tue Jul 21, 2020 03:00
Cancers, Vol. 12, Pages 1983: Integration of Serum Metabolomics into Clinical Assessment to Improve Outcome Prediction of Metastatic Soft Tissue Sarcoma Patients Treated with Trabectedin Cancers doi: 10.3390/cancers12071983 Authors: Gianmaria Miolo Emanuela Di Gregorio Asia Saorin Davide Lombardi Simona Scalone Angela Buonadonna Agostino Steffan Giuseppe Corona Soft tissue sarcomas (STS) are a group of rare and heterogeneous cancers with few diagnostic or prognostic...
Tue Jul 21, 2020 03:00
Cancers, Vol. 12, Pages 1985: Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis Cancers doi: 10.3390/cancers12071985 Authors: Andrea M. Tomko Erin G. Whynot Lee D. Ellis Denis J. Dupré In recent years, and even more since its legalization in several jurisdictions, cannabis and the endocannabinoid system have received an increasing amount of interest related to their potential exploitation in clinical settings. Cannabinoids have been suggested...
Tue Jul 21, 2020 03:00
Cancers, Vol. 12, Pages 1982: The Biological Role of Sponge Circular RNAs in Gastric Cancer: Main Players or Coadjuvants? Cancers doi: 10.3390/cancers12071982 Authors: Adenilson Leão Pereira Leandro Magalhães Rafael Pompeu Pantoja Gilderlanio Araújo Ândrea Ribeiro-dos-Santos Amanda Ferreira Vidal Circular RNAs (circRNAs) are a new class of long noncoding RNAs able to perform multiple functions, including sponging microRNAs (miRNAs) and RNA-Binding Proteins (RBPs). They...
Tue Jul 21, 2020 03:00
Cells, Vol. 9, Pages 1747: Senescence and Host–Pathogen Interactions Cells doi: 10.3390/cells9071747 Authors: Daniel Humphreys Mohamed ElGhazaly Teresa Frisan Damage to our genomes triggers cellular senescence characterised by stable cell cycle arrest and a pro-inflammatory secretome that prevents the unrestricted growth of cells with pathological potential. In this way, senescence can be considered a powerful innate defence against cancer and viral infection. However, damage accumulated...
Tue Jul 21, 2020 03:00
Cells, Vol. 9, Pages 1745: Ribosomal Protein uL11 as a Regulator of Metabolic Circuits Related to Aging and Cell Cycle Cells doi: 10.3390/cells9071745 Authors: Mateusz Mołoń Eliza Molestak Monika Kula-Maximenko Przemysław Grela Marek Tchórzewski Aging is a biological phenomenon common to all living organisms. It is thought that the rate of aging is influenced by diverse factors, in many cases related to the control of energy metabolism, i.e., the so-called pro-longevity effects...
Tue Jul 21, 2020 03:00
Cells, Vol. 9, Pages 1741: Highly Efficient Conversion of Motor Neuron-Like NSC-34 Cells into Functional Motor Neurons by Prostaglandin E2 Cells doi: 10.3390/cells9071741 Authors: Hiroshi Nango Yasuhiro Kosuge Masaki Sato Yoshiyuki Shibukawa Yuri Aono Tadashi Saigusa Yoshihisa Ito Kumiko Ishige Motor neuron diseases are a group of progressive neurological disorders that degenerate motor neurons. The neuroblastoma × spinal cord hybrid cell line NSC-34 is...
Tue Jul 21, 2020 03:00
Cells, Vol. 9, Pages 1744: Hydrodynamics-Based Transplacental Delivery as a Useful Noninvasive Tool for Manipulating Fetal Genome Cells doi: 10.3390/cells9071744 Authors: Shingo Nakamura Naoko Ando Satoshi Watanabe Eri Akasaka Masayuki Ishihara Masahiro Sato We previously demonstrated that the injection of pregnant wild-type female mice (carrying enhanced green fluorescent protein (EGFP)-expressing transgenic fetuses) at embryonic day (E) 12.5 with an all-in-one plasmid...
Tue Jul 21, 2020 03:00
Cells, Vol. 9, Pages 1742: Annexin-A6 in Membrane Repair of Human Skeletal Muscle Cell: A Role in the Cap Subdomain Cells doi: 10.3390/cells9071742 Authors: Coralie Croissant Céline Gounou Flora Bouvet Sisareuth Tan Anthony Bouter Defects in membrane repair contribute to the development of some muscular dystrophies, highlighting the importance to decipher the membrane repair mechanisms in human skeletal muscle. In murine myofibers, the formation of a cap subdomain composed...
Tue Jul 21, 2020 03:00
Cells, Vol. 9, Pages 1743: Hyaluronic Acid: Redefining Its Role Cells doi: 10.3390/cells9071743 Authors: G. Abatangelo V. Vindigni G. Avruscio L. Pandis P. Brun The discovery of several unexpected complex biological roles of hyaluronic acid (HA) has promoted new research impetus for biologists and, the clinical interest in several fields of medicine, such as ophthalmology, articular pathologies, cutaneous repair, skin remodeling, vascular prosthesis, adipose tissue engineering,...
Tue Jul 21, 2020 03:00
Cells, Vol. 9, Pages 1746: Emerging Roles of Inhibitor of Differentiation-1 in Alzheimer’s Disease: Cell Cycle Reentry and Beyond Cells doi: 10.3390/cells9071746 Authors: Shang-Der Chen Jenq-Lin Yang Yi-Chun Lin A-Ching Chao Ding-I Yang Inhibitor of DNA-binding/differentiation (Id) proteins, a family of helix-loop-helix (HLH) proteins that includes four members of Id1 to Id4 in mammalian cells, are critical for regulating cell growth, differentiation, senescence, cell cycle...
Tue Jul 21, 2020 03:00
Cells, Vol. 9, Pages 1737: The Leukemic Fly: Promises and Challenges Cells doi: 10.3390/cells9071737 Authors: Amani Al Outa Dana Abubaker Joelle Madi Rihab Nasr Margret Shirinian Leukemia involves different types of blood cancers, which lead to significant mortality and morbidity. Murine models of leukemia have been instrumental in understanding the biology of the disease and identifying therapeutics. However, such models are time consuming and expensive in high throughput...
Tue Jul 21, 2020 03:00
Cells, Vol. 9, Pages 1740: The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain Cells doi: 10.3390/cells9071740 Authors: Osthues Zimmer Rimola Klann Schilling Mathoor Angioni Weigert Geisslinger Münch Scholich Sisignano Nerve injury-induced neuropathic pain is difficult to treat and mechanistically characterized by strong neuroimmune interactions, involving signaling lipids that act via specific...
Tue Jul 21, 2020 03:00
Cells, Vol. 9, Pages 1738: Comment on “Dexamethasone Inhibits Spheroid Formation of Thyroid Cancer Cells Exposed to Simulated Microgravity” Cells doi: 10.3390/cells9071738 Authors: Joseph J. Bevelacqua James Welsh S.M.J. Mortazavi This letter addresses our concerns about a paper by Melnik et al [...]
Tue Jul 21, 2020 03:00
Cells, Vol. 9, Pages 1739: Adenosine Receptors as Neuroinflammation Modulators: Role of A1 Agonists and A2A Antagonists Cells doi: 10.3390/cells9071739 Authors: Aleix Martí Navia Diego Dal Ben Catia Lambertucci Andrea Spinaci Rosaria Volpini Joana E. Coelho Luísa V. Lopes Inês Marques-Morgado Gabriella Marucci Michela Buccioni The pathological condition of neuroinflammation is caused by the activation of the neuroimmune cells astrocytes and microglia. The autacoid...
Tue Jul 21, 2020 03:00
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