IJMS, Vol. 21, Pages 5168: Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes International Journal of Molecular Sciences doi: 10.3390/ijms21145168 Authors: Corlia Grobler Siphosethu C. Maphumulo L. Meirelie Grobbelaar Jhade C. Bredenkamp Gert J. Laubscher Petrus J. Lourens Janami Steenkamp Douglas B. Kell Etheresia Pretorius Severe acute respiratory...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5173: Salivary Biomarkers and Their Application in the Diagnosis and Monitoring of the Most Common Oral Pathologies International Journal of Molecular Sciences doi: 10.3390/ijms21145173 Authors: Lucía Melguizo-Rodríguez Victor J. Costela-Ruiz Francisco Javier Manzano-Moreno Concepción Ruiz Rebeca Illescas-Montes Saliva is a highly versatile biological fluid that is easy to gather in a non-invasive manner—and the results of its analysis complement...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5172: Parity Attenuates Intraepithelial Corneal Sensory Nerve Loss in Female Mice International Journal of Molecular Sciences doi: 10.3390/ijms21145172 Authors: Mary Ann Stepp Sonali Pal-Ghosh Gauri Tadvalkar Cintia S. de Paiva Aging impacts the ocular surface and reduces intraepithelial corneal nerve (ICN) density in male and female mice. Many researchers use retired breeders to study naturally aged female mice. Yet, the impact of parity and the length...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5170: Trans-Axonal Signaling in Neural Circuit Wiring International Journal of Molecular Sciences doi: 10.3390/ijms21145170 Authors: Olivia Spead Fabienne E. Poulain The development of neural circuits is a complex process that relies on the proper navigation of axons through their environment to their appropriate targets. While axon–environment and axon–target interactions have long been known as essential for circuit formation, communication...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5169: Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption International Journal of Molecular Sciences doi: 10.3390/ijms21145169 Authors: Hideki Kitaura Aseel Marahleh Fumitoshi Ohori Takahiro Noguchi Wei-Ren Shen Jiawei Qi Yasuhiko Nara Adya Pramusita Ria Kinjo Itaru Mizoguchi The process of bone remodeling is the result of the regulated balance between bone cell populations, namely bone-forming osteoblasts, bone-resorbing...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5167: Different Mechanisms underlie the Metabolic Response of GBM Stem-Like Cells to Ionizing Radiation: Biological and MRS Studies on Effects of Photons and Carbon Ions International Journal of Molecular Sciences doi: 10.3390/ijms21145167 Authors: Alessandra Palma Sveva Grande Lucia Ricci-Vitiani Anna Maria Luciani Mariachiara Buccarelli Mauro Biffoni Valentina Dini Giuseppe A.P. Cirrone Mario Ciocca Laura Guidoni Roberto Pallini Vincenza...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5171: Protective Effect of Epigallocatechin-3-Gallate (EGCG) in Diseases with Uncontrolled Immune Activation: Could Such a Scenario Be Helpful to Counteract COVID-19? International Journal of Molecular Sciences doi: 10.3390/ijms21145171 Authors: Marta Menegazzi Rachele Campagnari Mariarita Bertoldi Rosalia Crupi Rosanna Di Paola Salvatore Cuzzocrea Some coronavirus disease 2019 (COVID-19) patients develop acute pneumonia which can result in a cytokine...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5165: Dual Inhibition of CDK4/6 and PI3K/AKT/mTOR Signaling Impairs Energy Metabolism in MPM Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21145165 Authors: Mara Bonelli Rita Terenziani Silvia Zoppi Claudia Fumarola Silvia La Monica Daniele Cretella Roberta Alfieri Andrea Cavazzoni Graziana Digiacomo Maricla Galetti Pier Giorgio Petronini Background: Malignant pleural mesothelioma (MPM) is an aggressive malignancy...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5164: Small Molecule NF-kB Pathway Inhibitors in Clinic International Journal of Molecular Sciences doi: 10.3390/ijms21145164 Authors: Venkataramanan Ramadass Thamilselvan Vaiyapuri Vinay Tergaonkar Nuclear factor kappa B (NF-kB) signaling is implicated in all major human chronic diseases, with its role in transcription of hundreds of gene well established in the literature. This has propelled research into targeting the NF-kB pathways for modulating expression...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5166: Resolution-Associated Lactoferrin Peptides Limit LPS Signaling and Cytokine Secretion from Human Macrophages International Journal of Molecular Sciences doi: 10.3390/ijms21145166 Authors: Aviv Lutaty Soaad Soboh Sagie Schif-Zuck Amiram Ariel The neutrophil granule protein lactoferrin is cleaved and accumulates in efferocytic macrophages as inflammation is resolved. Two peptides present within a resolution-associated 17 kDa fragment of lactoferrin promote...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5162: Identification of Subclinical Lung Involvement in ACPA-Positive Subjects through Functional Assessment and Serum Biomarkers International Journal of Molecular Sciences doi: 10.3390/ijms21145162 Authors: Bruno Lucchino Marcello Di Paolo Chiara Gioia Marta Vomero Davide Diacinti Cristina Mollica Cristiano Alessandri Daniele Diacinti Paolo Palange Manuela Di Franco Lung involvement is related to the natural history of anti-citrullinated...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5160: EPAC in Vascular Smooth Muscle Cells International Journal of Molecular Sciences doi: 10.3390/ijms21145160 Authors: Nadine Wehbe Suzanne Awni Nasser Yusra Al-Dhaheri Rabah Iratni Alessandra Bitto Ahmed F. El-Yazbi Adnan Badran Firas Kobeissy Elias Baydoun Ali H. Eid Vascular smooth muscle cells (VSMCs) are major components of blood vessels. They regulate physiological functions, such as vascular tone and blood flow. Under pathological...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5161: Intrinsic Regulatory Role of RNA Structural Arrangement in Alternative Splicing Control International Journal of Molecular Sciences doi: 10.3390/ijms21145161 Authors: Katarzyna Taylor Krzysztof Sobczak Alternative splicing is a highly sophisticated process, playing a significant role in posttranscriptional gene expression and underlying the diversity and complexity of organisms. Its regulation is multilayered, including an intrinsic role of RNA structural...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5163: Therapeutic Potentials of Extracellular Vesicles for the Treatment of Diabetes and Diabetic Complications International Journal of Molecular Sciences doi: 10.3390/ijms21145163 Authors: Wei Hu Xiang Song Haibo Yu Jingyu Sun Yong Zhao Extracellular vesicles (EVs), including exosomes and microvesicles, are nano-to-micrometer vesicles released from nearly all cellular types. EVs comprise a mixture of bioactive molecules (e.g., mRNAs, miRNAs, lipids,...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5154: Emerging Roles for Neuropilin-2 in Cardiovascular Disease International Journal of Molecular Sciences doi: 10.3390/ijms21145154 Authors: Jennifer L. Harman Jacob Sayers Chey Chapman Caroline Pellet-Many Cardiovascular disease, the leading cause of death worldwide, is predominantly associated with atherosclerosis. Atherosclerosis is a chronic inflammatory disease characterised by the narrowing of large to medium-sized arteries due to a build-up of plaque....
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5155: The Application of Molecular Spectroscopy in Combination with Chemometrics for Halal Authentication Analysis: A Review International Journal of Molecular Sciences doi: 10.3390/ijms21145155 Authors: Abdul Rohman Anjar Windarsih Halal is an Arabic term used to describe any components allowed to be used in any products by Muslim communities. Halal food and halal pharmaceuticals are any food and pharmaceuticals which are safe and allowed to be consumed according...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5159: Correction: Sato, K., et al. Identification of a Novel Oligosaccharide in Maple Syrup as a Potential Alternative Saccharide for Diabetes Mellitus Patients. Int. J. Mol. Sci. 2019, 20, 5041 International Journal of Molecular Sciences doi: 10.3390/ijms21145159 Authors: Kanta Sato Noriaki Nagai Tetsushi Yamamoto Kuniko Mitamura Atsushi Taga The authors wish to make the following corrections to this paper [...]
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5158: Arming Oncolytic Adenoviruses: Effect of Insertion Site and Splice Acceptor on Transgene Expression and Viral Fitness International Journal of Molecular Sciences doi: 10.3390/ijms21145158 Authors: Martí Farrera-Sal Jana de Sostoa Estela Nuñez-Manchón Rafael Moreno Cristina Fillat Miriam Bazan-Peregrino Ramon Alemany Oncolytic adenoviruses (OAds) present limited efficacy in clinics. The insertion of therapeutic transgenes into OAds genomes,...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5153: Red and Yellow Injectable Platelet-Rich Fibrin Demonstrated Differential Effects on Periodontal Ligament Stem Cell Proliferation, Migration, and Osteogenic Differentiation International Journal of Molecular Sciences doi: 10.3390/ijms21145153 Authors: Prakan Thanasrisuebwong Sirichai Kiattavorncharoen Rudee Surarit Chareerut Phruksaniyom Nisarat Ruangsawasdi The biological benefits of using two fractions derived from injectable platelet-rich fibrin...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5156: Clinical Role of Extraoral Bitter Taste Receptors International Journal of Molecular Sciences doi: 10.3390/ijms21145156 Authors: Joanna Jeruzal-Świątecka Wojciech Fendler Wioletta Pietruszewska Humans can recognise five basic tastes: sweet, sour, salty, bitter and umami. Sour and salty substances are linked to ion channels, while sweet, bitter and umami flavours are transmitted through receptors linked to the G protein (G protein-coupled receptors; GPCRs)....
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5157: Rapid Regulation of Human Multidrug and Extrusion Transporters hMATE1 and hMATE2K International Journal of Molecular Sciences doi: 10.3390/ijms21145157 Authors: Marta Kantauskaitė Anna Hucke Moritz Reike Sara Ahmed Eltayeb Chuyan Xiao Vivien Barz Giuliano Ciarimboli Vectorial transport of organic cations (OCs) in renal proximal tubules is mediated by sequential action of human OC transporter 2 (hOCT2) and human multidrug and toxic extrusion...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5150: Herpes Simplex Virus Type 1 Interactions with the Interferon System International Journal of Molecular Sciences doi: 10.3390/ijms21145150 Authors: Kevin Danastas Monica Miranda-Saksena Anthony L. Cunningham The interferon (IFN) system is one of the first lines of defense activated against invading viral pathogens. Upon secretion, IFNs activate a signaling cascade resulting in the production of several interferon stimulated genes (ISGs), which work to...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5151: The Role of miR-375-3p and miR-200b-3p in Gastrointestinal Stromal Tumors
IJMS, Vol. 21, Pages 5151: The Role of miR-375-3p and miR-200b-3p in Gastrointestinal Stromal Tumors International Journal of Molecular Sciences doi: 10.3390/ijms21145151 Authors: Ugne Gyvyte Rokas Lukosevicius Ruta Inciuraite Greta Streleckiene Greta Gudoityte Justina Bekampyte Serena Valentini Violeta Salteniene Paulius Ruzgys Saulius Satkauskas Kristina Zviniene Juozas Kupcinskas Jurgita Skieceviciene Deregulated microRNA (miRNA) expression profiles...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5152: A Comprehensive Mapping of the Druggable Cavities within the SARS-CoV-2 Therapeutically Relevant Proteins by Combining Pocket and Docking Searches as Implemented in Pockets 2.0 International Journal of Molecular Sciences doi: 10.3390/ijms21145152 Authors: Silvia Gervasoni Giulio Vistoli Carmine Talarico Candida Manelfi Andrea R. Beccari Gabriel Studer Gerardo Tauriello Andrew Mark Waterhouse Torsten Schwede Alessandro Pedretti (1)...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5149: Endosomal-Lysosomal Processing of Neurodegeneration-Associated Proteins in Astrocytes International Journal of Molecular Sciences doi: 10.3390/ijms21145149 Authors: Ching-On Wong Most common neurodegenerative diseases (NDs) are characterized by deposition of protein aggregates that are resulted from misfolding, dysregulated trafficking, and compromised proteolytic degradation. These proteins exert cellular toxicity to a broad range of brain cells and are found...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5146: A Fish Leukocyte Immune-Type Receptor Uses a Novel Intracytoplasmic Tail Networking Mechanism to Cross-Inhibit the Phagocytic Response International Journal of Molecular Sciences doi: 10.3390/ijms21145146 Authors: Chenjie Fei Myron A. Zwozdesky James L. Stafford Channel catfish (Ictalurus punctatus) leukocyte immune-type receptors (IpLITRs) are a family of immunoregulatory proteins shown to regulate several innate immune cell effector responses, including...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5147: ATG4 Mediated Psm ES4326/AvrRpt2-Induced Autophagy Dependent on Salicylic Acid in Arabidopsis Thaliana International Journal of Molecular Sciences doi: 10.3390/ijms21145147 Authors: Wenjun Gong Bingcong Li Baihong Zhang Wenli Chen Psm ES4326/AvrRpt2 (AvrRpt2) was widely used as the reaction system of hypersensitive response (HR) in Arabidopsis. The study showed that in npr1 (GFP-ATG8a), AvrRpt2 was more effective at inducing the production of autophagosome...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5148: The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21145148 Authors: Rawnaq Esa Eliana Steinberg Dvir Dror Ouri Schwob Mehrdad Khajavi Myriam Maoz Yael Kinarty Adi Inbal Aviad Zick Ofra Benny During the metastasis process, tumor cells invade the blood circulatory system directly from venous capillaries or indirectly via lymphatic vessels. Understanding the relative...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5143: Structural Features of Carnivorous Plant (Genlisea, Utricularia) Tubers as Abiotic Stress Resistance Organs International Journal of Molecular Sciences doi: 10.3390/ijms21145143 Authors: Bartosz J. Płachno Saura R. Silva Piotr Świątek Kingsley W. Dixon Krzystof Lustofin Guilherme C. Seber Vitor F. O. Miranda Carnivorous plants from the Lentibulariaceae form a variety of standard and novel vegetative organs and survive unfavorable environmental...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5144: The New Frontier in Oxytocin Physiology: The Oxytonic Contraction International Journal of Molecular Sciences doi: 10.3390/ijms21145144 Authors: Claudia Camerino Oxytocin (Oxt) is a nine amino acid peptide important in energy regulation and is essential to stress-related disorders. Specifically, low Oxt levels are associated with obesity in human subjects and diet-induced or genetically modified animal models. The striking evidence that Oxt is linked to energy...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5145: COVID-19: A Review on Diagnosis, Treatment, and Prophylaxis International Journal of Molecular Sciences doi: 10.3390/ijms21145145 Authors: Alessandra Fierabracci Andrea Arena Paolo Rossi Coronavirus 2 (CoV) Severe Acute Respiratory Syndrome (SARS-CoV2) is causing a highly infectious pandemic pneumonia. Coronaviruses are positive sense single-stranded RNA viruses that infect several animal species, causing symptoms that range from those similar to the...
Tue Jul 21, 2020 03:00
IJMS, Vol. 21, Pages 5142: Suppression of Ocular Vascular Inflammation through Peptide-Mediated Activation of Angiopoietin-Tie2 Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21145142 Authors: Adam C. Mirando Raquel Lima e Silva Zenny Chu Peter A. Campochiaro Niranjan B. Pandey Aleksander S. Popel Persistent inflammation is a complication associated with many ocular diseases. Changes in ocular vessels can amplify disease responses and contribute...
Tue Jul 21, 2020 03:00
JCM, Vol. 9, Pages 2321: Rate of Change in Bruch’s Membrane Opening-Minimum Rim Width and Peripapillary RNFL in Early Normal Tension Glaucoma Journal of Clinical Medicine doi: 10.3390/jcm9082321 Authors: Hyun-kyung Cho Changwon Kee Background: to investigate the rate of change (ROC) of Bruch’s membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (RNFL) thickness in early normal tension glaucoma (NTG) patients. Methods: in this longitudinal...
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JCM, Vol. 9, Pages 2320: Genotype and Phenotype Analyses in Pediatric Patients with HNF1B Mutations Journal of Clinical Medicine doi: 10.3390/jcm9072320 Authors: Seon Hee Lim Ji Hyun Kim Kyoung Hee Han Yo Han Ahn Hee Gyung Kang Il-Soo Ha Hae Il Cheong HNF1B mutations, one of the most common causes of congenital anomalies of the kidney and urinary tract, manifest as various renal and extrarenal phenotypes. We analyzed the genotype-phenotype correlations in 14 pediatric...
Tue Jul 21, 2020 03:00
JCM, Vol. 9, Pages 2319: Surgery and Perioperative Management in Small Intestinal Neuroendocrine Tumors Journal of Clinical Medicine doi: 10.3390/jcm9072319 Authors: Deguelte Perrier Hammoutene Cadiot Kianmanesh Small-intestinal neuroendocrine tumors (SI-NETs) are the most prevalent small bowel neoplasms with an increasing frequency. In the multimodal management of SI-NETs, surgery plays a key role, either in curative intent, even if R0 resection is feasible in only...
Tue Jul 21, 2020 03:00
JCM, Vol. 9, Pages 2317: Inhaled Dry Powder Antibiotics in Patients with Non-Cystic Fibrosis Bronchiectasis: Efficacy and Safety in a Real-Life Study Journal of Clinical Medicine doi: 10.3390/jcm9072317 Authors: Miguel Ángel Martínez-García Grace Oscullo Esther Barreiro Selene Cuenca Angela Cervera Alicia Padilla-Galo David de la Rosa Annie Navarro Rosa Giron Francisco Carbonero Maria Castro Otero Francisco Casas Background: Nebulised antibiotics are...
Tue Jul 21, 2020 03:00
JCM, Vol. 9, Pages 2314: Effects of Biofeedback Training on Esophageal Peristalsis in Amyotrophic Lateral Sclerosis Patients with Dysphagia Journal of Clinical Medicine doi: 10.3390/jcm9072314 Authors: Jerzy Tomik Klaudia Sowula Piotr Ceranowicz Mateusz Dworak Kamila Stolcman Esophageal manometry (EM) could serve as an objective method for the detection of esophageal peristalsis in patients with amyotrophic lateral sclerosis (ALS). In this group of patients, biofeedback training...
Tue Jul 21, 2020 03:00
JCM, Vol. 9, Pages 2315: The Plasmatic Aldosterone and C-Reactive Protein Levels, and the Severity of Covid-19: The Dyhor-19 Study Journal of Clinical Medicine doi: 10.3390/jcm9072315 Authors: Villard Morquin Molinari Raingeard Nagot Cristol Jung Roubille Foulongne Fesler Lamure Taourel Konate Maria Makinson Bertchansky Larcher Klouche Le Moing Renard Guilpain Background. The new coronavirus SARS-CoV-2,...
Tue Jul 21, 2020 03:00
JCM, Vol. 9, Pages 2313: Accuracy of Panoramic Radiograph for Diagnosing Periodontitis Comparing to Clinical Examination Journal of Clinical Medicine doi: 10.3390/jcm9072313 Authors: Vanessa Machado Luís Proença Mariana Morgado José João Mendes João Botelho In this study, we explore the diagnostic accuracy of a Radiographic-based Periodontal Bone Loss (R-PBL) method as a screening tool for periodontitis, in the form of radiographic bone loss, under the 2018 case definition...
Tue Jul 21, 2020 03:00
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