Objective: To evaluate the incidence of and characterize the presentation of neuropsychiatric symptoms and/or Parkinsonism as a presentation of central nervous system lymphoma (CNSL) in either its primary CNSL form or when it spreads to the brain in systemic diffuse large B-cell lymphoma (secondary CNSL). Patients and Methods: With Institutional Review Board approval we identified patients who had been treated at Mayo Clinic from 1998 to 2018 and were recorded to have a combination...
Fri Jul 17, 2020 03:00
Objectives: Clinical concerns about hematologic toxicities in human immunodeficiency virus (HIV)+ patients with squamous cell anal cancer (SCAC) may lead to de-escalation of treatment intensity. The objective of this study is to evaluate clinical outcomes including toxicity following standard concurrent curative-intent chemoradiation for HIV+ and HIV− patients with SCAC. Materials and Methods: Among 97 evaluable patients treated between 2009 and 2016 (median age 52.2 y), 43 (44.3%)...
Fri Jul 17, 2020 03:00
Objectives: Pathologic fractures from bone metastases can significantly affect quality-of-life, although it is unclear which patients may be at high risk of this outcome. We aim to determine risk factors for pathologic fracture among patients admitted with bone metastases and to evaluate the association of pathologic fracture with clinical and economic outcomes. Methods: The Healthcare Cost and Utilization Project National Inpatient Sample was queried for all patients hospitalized with...
Fri Jul 17, 2020 03:00
Background Social isolation has shown robust associations with clinical outcomes in the general population and in patients with cancer. In patients with ovarian cancer, social isolation has been found to be related to decreased survival and multiple biomarkers supporting tumor progression. However, to the authors' knowledge, little is known regarding the relationship between social isolation and the molecular characteristics of ovarian tumors. Herein, the authors have used genome‐wide transcriptional...
Tue Jul 21, 2020 15:06
02:25
British Journal of Cancer, Published online: 22 July 2020; doi:10.1038/s41416-020-0986-4Immunotherapy in older patients with non-small cell lung cancer: Young International Society of Geriatric Oncology position paper
01:45
British Journal of Cancer, Published online: 22 July 2020; doi:10.1038/s41416-020-0987-3Current and novel therapeutic opportunities for systemic therapy in biliary cancer
01:45
British Journal of Cancer, Published online: 21 July 2020; doi:10.1038/s41416-020-0998-0Correction: Integrated single-cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC-sensitive cell lines
Tue Jul 21, 2020 03:00
Tue Jul 21, 2020 03:00
Mon Jul 20, 2020 10:39
Abstract Cell Cycle and Apoptosis Regulator 1 (CCAR1) and Cell Cycle and Apoptosis Regulator 2 (CCAR2) have emerged as key players in physiology and pathophysiology, with critical roles in the DNA damage response, nuclear receptor function and Wnt signaling, among other activities. Contradictory reports exist on the functional duality of CCAR1 and CCAR2 as either tumor promoters or suppressors, suggesting that CCAR1 and CCAR2 have the hallmarks of gene chameleons. We review herein the mechanistic,...
Tue Jul 21, 2020 21:09
Abstract Baicalein, a flavonoid phytochemical, has been proved to be effective in anti‐metastatic activity for various cancers, especially for non‐small cell lung cancer (NSCLC). However, the underlying mechanism of how Baicalein targets the cellular mechanical activities during NSCLC cell invasion and metastasis remains elusive. In this study, we found that non‐cytotoxic concentration of Baicalein still retain anti‐dissemination activity both in vitro and in vivo . Using the genetic encoding tension...
Tue Jul 21, 2020 14:59
Abstract ABT‐263 (Navitoclax) is one of the BH3‐mimetic drugs targeting anti‐apoptotic B‐cell lymphoma‐2 (BCL‐2) family proteins, including BCL‐2, BCL‐xL, and BCL‐w, thereby inducing apoptosis. In small cell lung cancer (SCLC) cells, the response to ABT‐263 is associated with the expression of the myeloid cell leukemia‐1 (MCL‐1) protein. However, the efficacy of ABT‐263 in non‐small cell lung cancer (NSCLC) has not been thoroughly evaluated. In addition, there are currently no established biomarkers...
Mon Jul 20, 2020 22:33
It is well established that individuals with diabetes mellitus (DM) may develop exocrine pancreatic dysfunction (EPD) requiring pancreatic enzyme replacement therapy, whereas the converse relationship has been poorly studied. Pancreatitis is a disease that is well suited to investigate the latter as it is often characterized by the development of EPD and/or new‐onset DM. The aim was to investigate the association between EPD and the risk of new‐onset DM in individuals after the first attack of pancreatitis....
Tue Jul 21, 2020 21:04
Purpose: ZEN-3694 is a bromodomain extra-terminal inhibitor (BETi) with activity in androgen signaling inhibitor (ASI)-resistant models. The safety and efficacy of ZEN-3694 plus enzalutamide (ENZ) was evaluated in a phase 1b/2a study in metastatic castration-resistant prostate cancer (mCRPC). Experimental Design: Patients had progressive mCRPC with prior resistance to abiraterone (ABI) and/or ENZ. 3+3 dose escalation was followed by dose expansion in parallel cohorts (ZEN-3694 at 48 and 96 mg orally...
Tue Jul 21, 2020 15:04
Purpose: This is a phase 1/2 trial of napabucasin plus pembrolizumab for metastatic colorectal cancer (mCRC). Experimental Design: Phase 1 was conducted to determine the recommended phase 2 dose (RP2D) in a dose escalation design of napabucasin (240mg to 480 mg twice daily) with 200mg pembrolizumab every 3 weeks. Phase 2 included cohort A (n = 10, microsatellite instability high) and cohort B (n = 40, microsatellite stable). The primary endpoint was immune-related objective response rate (irORR)....
Tue Jul 21, 2020 15:04
Purpose: The primary objective was to evaluate intracranial objective response rate (iORR) in patients receiving abemaciclib with brain or leptomeningeal metastases (BM or LM) secondary to HR+ MBC. Secondary objectives evaluated extracranial response, abemaciclib pharmacokinetics, BM tissue exposure, and safety. Experimental Design: This nonrandomized, phase 2 study (NCT02308020) enrolled patients in tumor subtype-specific cohorts A-D: A (HR+, HER2- MBC), B (HR+, HER2+ MBC), C (HR+ MBC leptomeningeal...
Tue Jul 21, 2020 15:04
Purpose: DLYE5953A is an antibody-drug conjugate consisting of an anti-LY6E antibody covalently linked to the cytotoxic agent monomethyl auristatin E. This study characterized the safety, pharmacokinetics, immunogenicity, potential biomarkers, and anti-tumor activity of DLYE5953A in patients with metastatic solid tumors. Experimental design: This was a phase I, open-label, 3+3 dose-escalation, and dose expansion study of DLYE5953A administered intravenously every 21 days (Q3W) in patients with locally...
Tue Jul 21, 2020 15:04
Purpose: (4S)-4-(3-[18F]Fluoropropyl)-L-glutamic acid (18F-FSPG) is a radiopharmaceutical for PET imaging of system xC- activity, which can be upregulated in prostate cancer. We present data on the first evaluation of newly diagnosed or recurrent prostate cancer patients with this radiopharmaceutical. Experimental Design: Ten primary and ten recurrent prostate cancer patients were enrolled in this prospective multicenter study. After injection of 300 MBq of 18F-FSPG, three whole-body PET/CT scans...
Tue Jul 21, 2020 15:04
Purpose: Glioblastoma (GBM) is one of the deadliest cancers with no cure. While conventional MRI has been widely adopted for examining GBM clinically, accurate neuroimaging assessment of tumor histopathology for improved diagnosis, surgical planning, and treatment evaluation, remains an unmet need in the clinical management of GBMs. Experimental Design: We employ a novel Diffusion Histology Imaging (DHI) approach, combining diffusion basis spectrum imaging (DBSI) and machine learning, to detect,...
Tue Jul 21, 2020 15:04
Purpose: The ATM gene is mutated in a subset of prostate cancers, and ATM mutation may confer specific therapeutic vulnerabilities, though ATM-deficient prostate cancers have not been well-characterized. Experimental Design: We genetically validated a clinical-grade immunohistochemistry (IHC) assay to detect ATM protein loss and examined the frequency of ATM loss among tumors with pathogenic germline ATM mutations and genetically unselected primary prostate carcinomas using tissue microarrays (TMA)....
Tue Jul 21, 2020 15:04
Background: The recombinant fusion protein ipafricept (IPA) blocks Wnt signaling, and in combination with gemcitabine (G) and nab-paclitaxel (Nab-P) caused tumor regression in xenografts. This phase 1b study evaluated the combination of IPA with Nab-P+G in untreated metastatic PDAC (mPDAC) patients. Methods: Dose escalation started with standard dose Nab-P+G and IPA (3.5 mg/kg days 1, 15). Due to fragility fractures seen with different anti-Wnt agents, following cohorts had >=6 patients treated...
Tue Jul 21, 2020 15:04
Publication date: September 2020Source: European Journal of Cancer, Volume 136Author(s): Dario Pasalic, Gwendolyn J. McGinnis, C. David Fuller, Aaron J. Grossberg, Vivek Verma, Walker Mainwaring, Austin B. Miller, Timothy A. Lin, Amit Jethanandani, Andres F. Espinoza, Markus Diefenhardt, Prajnan Das, Vivek Subbiah, Ishwaria M. Subbiah, Reshma Jagsi, Adam S. Garden, Emmanouil Fokas, Claus Rödel, Charles R. Thomas, Bruce D. Minsky
Tue Jul 21, 2020 15:17
Future Oncology, Ahead of Print.
Mon Jul 20, 2020 12:28
Future Oncology, Ahead of Print.
Mon Jul 20, 2020 12:07
Future Oncology, Ahead of Print.
Mon Jul 20, 2020 12:00
Future Oncology, Ahead of Print.
Mon Jul 20, 2020 10:47
Future Oncology, Ahead of Print.
Mon Jul 20, 2020 07:25
Future Oncology, Ahead of Print.
Mon Jul 20, 2020 07:11
Future Oncology, Ahead of Print.
Mon Jul 20, 2020 06:48
The m6A methylation regulator-based signature for predicting the prognosis of prostate cancer. Future Oncol. 2020 Jul 20;: Authors: Wang J, Lin H, Zhou M, Xiang Q, Deng Y, Luo L, Liu Y, Zhu Z, Zhao Z Abstract Aim: To construct a survival prediction signature for prostate cancer (PC) based on the RNA N6-methyladenosine (m6A) methylation regulator. Materials & methods: This paper explores the interaction network of differentially expressed...
Tue Jul 21, 2020 16:42
Cancer-associated fibroblasts of colorectal cancer and their markers: updates, challenges and translational outlook. Future Oncol. 2020 Jul 20;: Authors: Musa M, Ali A Abstract Accumulation of cancer-associated fibroblasts (CAFs) in the tumor microenvironment is associated with poor prognosis and recurrence of colorectal cancer (CRC). Despite their prominent roles in colorectal carcinogenesis, there is a lack of robust and specific markers...
Tue Jul 21, 2020 16:42
Effects of tumor types on treatment strategy formulation and prognostic evaluation of gastric neuroendocrine tumors. Future Oncol. 2020 Jul 20;: Authors: Jiao X, Wang Z, Peng X, Zhang L, Zhou L Abstract Aim: The effects of different types of gastric neuroendocrine tumors (G-NETs) on treatment strategy formulation and prognostic evaluation still remain controversial due to their rarity. Methods: 187 patients diagnosed with G-NETs were subdivided...
Tue Jul 21, 2020 16:42
Atypical patterns of response and progression in the era of immunotherapy combinations. Future Oncol. 2020 Jul 20;: Authors: Ferrara R, Matos I Abstract In the immunoncology era, an acceleration of tumor growth upon immune checkpoint inhibitors (ICI), defined as hyperprogressive disease (HPD) has been observed across different cancers. Although in non-small-cell lung cancer, most of the available evidence regarding HPD has been reported for...
Tue Jul 21, 2020 16:42
Prognostic role of targeted therapy in patients with multiple-site metastases from non-small- cell lung cancer. Future Oncol. 2020 Jul 20;: Authors: Meng C, Ge X, Tian J, Wei J, Zhao L Abstract Aim: To evaluate the prognostic role of EGFR mutations in patients with multi-site metastases from non-small-cell lung cancer (NSCLC). Patients & methods: A total of 215 advanced NSCLC patients with multi-site metastases were included. The overall...
Tue Jul 21, 2020 16:42
Pediatric low grade focal brainstem glioma: outcomes of different treatment strategies and prognostic factors. Future Oncol. 2020 Jul 20;: Authors: Elmaraghi C, Bishr MK, Mousa AG, Ahmed S, Refaat A, Elhemaly A, Ayadi ME, Taha H, Maher E, Elbeltagy M, Zaghloul MS Abstract Background: This study explores the prognostic factors and outcomes of different treatment modalities in focal brain stem glioma (FBSG). Materials & methods: Pediatric...
Tue Jul 21, 2020 16:42
Related Articles Modeling precision genomic-based radiation dose response in rectal cancer. Future Oncol. 2020 Jul 20;: Authors: Yuan Z, Frazer M, Ahmed KA, Naqvi SMH, Schell MJ, Felder S, Sanchez J, Dessureault S, Imanirad I, Kim RD, Torres-Roca JF, Hoffe SE, Frakes JM Abstract Aim: Genomic-based risk stratification to personalize radiation dose in rectal cancer. Patients & methods: We modeled genomic-based radiation dose response using...
Tue Jul 21, 2020 16:42
Long noncoding RNAs (lncRNAs) are considered critical regulators in cancers; however, the clinical significance and mechanisms of MAPKAPK5-AS1 (hereinafter referred to as MK5-AS1) in colorectal cancer (CRC) re...
Mon Jul 20, 2020 03:00
Abstract As standard treatments for cancer, DNA-damaging chemotherapeutic agents and irradiation therapy improve survival in patients with various cancers. Wee1, a kinase associated with the cell cycle, causes G2/M cell cycle arrest to allow repair of injured DNA in cancer cells, and a Wee1 inhibitor has been confirmed to lead to apoptosis in cancer cells. Recently, there has been renewed interest in exploring the immune environment which plays a significant role in tumour suppression....
Tue Jul 21, 2020 03:00
Abstract The bromodomain and extra‐terminal (BET) domain inhibitor JQ1 exerts potent anticancer activity in various cancer cells. However, the resistance to BET inhibitors in leukemia stem cells limits its implication in acute myeloid leukemia (AML). High concentration of triptolide (TPL) presents anticancer activities but with adverse effects. Here, we investigated whether the combination of low‐dose TPL with JQ1 could help to circumvent the dilemma of drug resistance and side effect in treating...
Tue Jul 21, 2020 14:39
Abstract The importance of tumour microenvironment in tumour behaviour has now become clearer. This study aimed to determine the prognostic effect of the proportion of tumour-stroma (PTS) in metastatic lymph nodes of advanced-stage colon cancers (CCs). We investigated PTS in positive lymph nodes of stage III-IV CC patients who underwent surgical treatment between 2004 and 2014. We used a standard approach in methodology. PTS was significantly associated with prognostic factors...
Tue Jul 21, 2020 03:00
A three‐tier process for screening depression and anxiety among children and adolescents with cancer
Abstract Objective To establish and to evaluate the effectiveness of a three‐tier screening process of depressive and anxiety disorders among children and adolescents with cancer based on questionnaires (first tier), semi‐structured psychiatric interviews (second tier), and referral for psychiatric assessment and recommendations for treatment (third tier). We also aimed to determine the rates of depressive and anxiety disorders among participants. Methods Participants and their parents...
Mon Jul 20, 2020 21:47
Mon Jul 20, 2020 21:44
Mon Jul 20, 2020 21:43
Abstract Objective Leventhal’s Common Sense Model (CSM) of self‐regulation highlights how specific beliefs about illness influence psychological outcomes. Little is known on how such beliefs relate to BRCA1/2 adjustment. Furthermore, beliefs about one’s self‐concept may be relevant to genetic conditions and may relate to psychological wellbeing. Methods 118 female BRCA1/2 carriers from an Irish University Hospital completed questionnaires for this cross‐sectional study. Outcomes measured...
Mon Jul 20, 2020 21:43
Abstract Purpose The aim was to evaluate the effects of co‐created internet‐based stepped care (iCAN‐DO) on anxiety, depression, posttraumatic stress, and health‐related quality of life (HRQoL) in individuals with cancer and self‐reported anxiety and/or depression symptoms, compared with standard care. Patients and methods Clinically recruited individuals with breast, colorectal, or prostate cancer underwent online screening with the Hospital Anxiety and Depression Scale (HADS). Those with...
Mon Jul 20, 2020 21:43
Abstract Objective This waiting‐list randomized controlled trial examined the effectiveness of a self‐management mHealth app in improving fatigue and quality of life (QoL) in cancer patients and survivors. Methods Persons with cancer‐related fatigue were recruited across four English speaking countries, via social media, and randomized into intervention (n = 519) and control (n = 280) groups. Whereas the intervention group received immediate access to the Untire app, the control group received...
Mon Jul 20, 2020 21:43
Abstract Objective This study investigates barriers and promoters to delivering quality psychosocial services in 58 cancer programs across North America. Methods Oncology care providers (n =2,008) participated in a survey in which they identified barriers and promoters for delivering psychosocial care at their respective institutions. Multilevel modeling was used to examine (1) the extent to which provider and institutional characteristics were associated with the most common barriers,...
Mon Jul 20, 2020 21:42
Mon Jul 20, 2020 21:41
Abstract Objective Impairment in the ability to provide informed consent is common in persons with brain metastasis. However, little is known about what factors contribute to this impairment in the patient group. Our objective is to determine if the associations between demographic, cognitive, and clinical variables correlate with the ability to provide informed consent in persons with brain metastasis. Methods We administered a comprehensive neuropsychological battery to a group of 61...
Mon Jul 20, 2020 21:41
Abstract Background The psychological resilience of postoperative non‐small cell lung cancer (NSCLC) patients is influenced by many factors. The purpose of this study is to investigate the current state of psychological resilience and identify its influencing factors in postoperative NSCLC patients. Methods This descriptive cross‐sectional study used a convenience sampling method and recruited 382 inpatients from two Class A hospitals in Hunan, China. The Connor‐Davidson Resilience Scale...
Mon Jul 20, 2020 21:39
Abstract Objective Caregiving does not have to be a totally negative experience for the husband caregivers of breast cancer survivors (BCS). There are growing interests in exploring the positive psychological changes (aka posttraumatic growth; PTG) among husbands of BCS. Western studies have shown that coping resources, cognitive appraisal, and coping strategies are associated with PTG among caregivers of BCS. Studies in the Chinese context are limited. This study examined the psychosocial correlates...
Mon Jul 20, 2020 21:37
Impaired function of masticatory muscles will lead to trismus. Routine delineation of these muscles during planning may improve dose tracking and facilitate dose reduction resulting in decreased radiation-rela...
Mon Jul 20, 2020 03:00
Publication date: August 2020Source: Cancer Epidemiology, Volume 67Author(s):
Tue Jul 21, 2020 16:43
Publication date: August 2020Source: Cancer Epidemiology, Volume 67Author(s):
Tue Jul 21, 2020 16:43
Publication date: Available online 20 July 2020Source: Surgical Oncology Clinics of North AmericaAuthor(s): Humberto K. Choi, Peter J. Mazzone
Tue Jul 21, 2020 17:17
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.