Related Articles Recurrent Spontaneous Pneumothorax in a 47-Year-Old Woman. Mil Med. 2020 Jul 20;: Authors: Guenther TM, Gustafson JD, Pribyl SM, Wozniak CJ Abstract Pneumothorax is a condition where air exists in the chest cavity, outside the lung. The causes of pneumothorax are numerous and determining the etiology can aid in treatment and prevent recurrence. We describe a 47-year-old female patient with past medical history of endometriosis...
Tue Jul 21, 2020 16:44
Long non-coding RNA SLCO4A1-AS1 drives the progression of non-small-cell lung cancer by modulating miR-223-3p/IKKα/NF-κB signaling. Cancer Biol Ther. 2020 Jul 20;:1-9 Authors: Li Q, Jiang B, Qi Y, Zhang H, Ma H Abstract Globally, lung cancer is known as a major cause of cancer-associated death and non-small-cell lung cancer (NSCLC) accounts for majority of all cases. Growing evidence has emerged that long non-coding RNAs (lncRNAs) act as vital...
Tue Jul 21, 2020 13:23
Related Articles Should drug discovery scientists still embrace the amyloid hypothesis for Alzheimer's disease or should they be looking elsewhere? Expert Opin Drug Discov. 2020 Jul 20;:1-11 Authors: Imbimbo BP, Ippati S, Watling M Abstract INTRODUCTION: Alzheimer's Disease (AD) represents a large and growing challenge to patients, carers and healthcare systems, yet extensive efforts to develop therapeutics to modify its course have been met...
Tue Jul 21, 2020 15:31
Related Articles Lessons learned from the discovery of sodium valproate and what has this meant to future drug discovery efforts? Expert Opin Drug Discov. 2020 Jul 20;:1-10 Authors: Janković SM, Janković SV Abstract INTRODUCTION: The discovery of of the anticonvulsant properties of valproic acid and the development of of valproic acid/valproate to market authorization for specific epilepsy types and syndromes, as well as their repurposing for...
Tue Jul 21, 2020 15:31
Related Articles Toll-like receptor (TLR) gene expression and immunostimulatory effect of CpG Oligonucleotides in hormone receptor positive cell line T47D and Triple negative breast cancer cell line MDA-MB-468. Immunopharmacol Immunotoxicol. 2020 Jul 19;:1-30 Authors: Natarajan S, Ranganathan M Abstract Background: We investigated the expression of TLR genes and the effects of CpG ODN in Estrogen Receptor positive, Progesterone Receptor positive...
Tue Jul 21, 2020 17:28
An Invited commentary on "NO alteration OF CYP3A4 activity after major hepatectomy in the early postoperative period - A prospective before-after study". Int J Surg. 2020 Jul 17;: Authors: Alikhanov R PMID: 32687874 [PubMed - as supplied by publisher]
Tue Jul 21, 2020 13:30
Health Policy and Leadership Models During the COVID-19 Pandemic- Review Article. Int J Surg. 2020 Jul 17;: Authors: Nicola M, Sohrabi C, Mathew G, Kerwan A, Al-Jabir A, Griffin M, Agha M, Agha R Abstract On 11th March 2020, the spread of the SARS-CoV-2 virus was declared a pandemic by the World Health Organisation (WHO). Approximately 5.6 million have now been infected and over 350,000 have died. This global public health crisis has since...
Tue Jul 21, 2020 13:30
NMMGenerator: An automatic neural mass model generator from population graphs. J Neural Eng. 2020 Jul 20;: Authors: Yochum M, Modolo J Abstract Neural mass models are among the most popular mathematical models of brain activity, since they enable the rapid simulation of large-scale networks involving different neural types at a spatial scale compatible with electrophysiological experiments (e.g., local field potentials). However, establishing...
Tue Jul 21, 2020 13:34
Related Articles Corrigendum to Lymphaticovenular anastomosis in elderly patients. [Journal of Plastic, Reconstructive & Aesthetic Surgery. Volume 73, Issue 6, June 2020, Pages 1174-1205]. J Plast Reconstr Aesthet Surg. 2020 Jul 17;: Authors: Onoda S, Kinoshita M PMID: 32684502 [PubMed - as supplied by publisher]
Tue Jul 21, 2020 14:28
Related Articles How to interpret clinical outcome data in plastic surgery research and clinical practice. J Plast Reconstr Aesthet Surg. 2020 Aug;73(8):1409-1412 Authors: Harrison CJ, Rodrigues JN Abstract Patient reported outcome measures (PROMs) are increasingly used in clinical and academic plastic surgery, but interpretation of PROMs is not always straightforward. Similarly, other clinical outcome data may also be challenging to interpret....
Tue Jul 21, 2020 14:28
Related Articles Invited editorial from the social media editor of JPRAS; Leadership in the time of COVID-19. J Plast Reconstr Aesthet Surg. 2020 Aug;73(8):1405-1408 Authors: Lindsay KJ, Leonard DA, Higgins GC, Robertson E, Perks G PMID: 32684344 [PubMed - in process]
Tue Jul 21, 2020 14:28
Related Articles Demystifying autoimmune small bowel enteropathy. Curr Opin Gastroenterol. 2019 05;35(3):243-249 Authors: Elli L, Ferretti F, Vaira V Abstract PURPOSE OF REVIEW: We reviewed the current 'state of the art' on autoimmune enteropathy and small-bowel mucosal atrophy, with the aim of supporting clinicians in a frequently challenging diagnosis through different therapeutic options and prognosis. RECENT FINDINGS: The diagnosis...
Tue Jul 21, 2020 14:54
Brown Syndrome from Local Anesthesia for Inferior Orbital Fat Decompression. Am J Case Rep. 2020 Jul 08;21:e924678 Authors: Alsarhani WK, Almater AI, Al-Ghamdi IS Abstract BACKGROUND Vertical diplopia that follows local anesthesia is usually due to inferior rectus muscle fibrosis. Here, we report a rare case of acquired Brown syndrome following local anesthesia. CASE REPORT A 36-year-old woman underwent right inferior orbital fat decompression...
Tue Jul 21, 2020 14:11
A 46-Year-Old Woman Who Presented with Diabetic Ketoacidosis and COVID-19 Pneumonia with Multiple Pulmonary Thromboemboli: A Case Report. Am J Case Rep. 2020 Jul 20;21:e925794 Authors: Haider MB, Abbas F, Hafeez W Abstract BACKGROUND Coronavirus disease 2019 (COVID-19) occurs because of a novel enveloped ribonucleic acid coronavirus called severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2). One of the major reported complications...
Tue Jul 21, 2020 14:11
Related Articles Primary Isolated Lymphoplasmacytic Lymphoma (LPL) of the Stomach: A Case Report. Am J Case Rep. 2020 Jul 20;21:e921840 Authors: Attallah HS, Moonim M, Fields P, Wrench D, Brady J, Mikhaeel NG Abstract BACKGROUND Lymphoplasmacytic lymphoma (LPL) is a mature B cell lymphoma that mostly involves the bone marrow, spleen, and lymph nodes. Involvement of extramedullary sites is very rare and has not been reported as the primary site...
Tue Jul 21, 2020 14:11
Related Articles Maxillomandibular Advancement and Upper Airway Stimulation: Extrapharyngeal Surgery for Obstructive Sleep Apnea. Clin Exp Otorhinolaryngol. 2020 Jul 21;: Authors: Yu MS, Ibrahim B, Riley RW, Liu SY Abstract There are many ways to categorize surgery for obstructive sleep apnea (OSA), one of which is to distinguish between intrapharyngeal and extrapharyngeal procedures. While the general otolaryngologist treating OSA is familiar...
Tue Jul 21, 2020 15:05
Related Articles Formaldehyde toxicity reports from in vitro and in vivo studies: a review and updated data. Drug Chem Toxicol. 2020 Jul 20;:1-13 Authors: Bernardini L, Barbosa E, Charão MF, Brucker N Abstract Formaldehyde (FA) is a xenobiotic air pollutant and its universal distribution causes a widespread exposure to humans. This review aimed to bring updated information concerning FA toxicity in humans and animals based on in vitro and in vivo...
Tue Jul 21, 2020 15:31
The landscape of tooth shape: Over 20 years of dental topography in primates. Evol Anthropol. 2020 Jul 20;: Authors: Berthaume MA, Lazzari V, Guy F Abstract Diet plays an incontrovertible role in primate evolution, affecting anatomy, growth and development, behavior, and social structure. It should come as no surprise that a myriad of methods for reconstructing diet have developed, mostly utilizing the element that is not only most common in...
Tue Jul 21, 2020 19:29
Related Articles Particle deposition and sensory drive. Evol Anthropol. 2020 Jul 20;: Authors: Poindexter SA, Garrett EC Abstract The mutualism between chemical cues emitted into the air and variations in how primates respond to them using olfaction has demonstrated aspects of species-specific adaptations. Building on this mutualism we can look at particle deposition as another means to understanding how various environments may have elicited...
Tue Jul 21, 2020 19:29
Laparoscopic liver resection of segment seven: A case report and review of surgical techniques. Int J Surg Case Rep. 2020 Jul 10;73:168-171 Authors: Takagi K, Kuise T, Umeda Y, Yoshida R, Teraishi F, Yagi T, Fujiwara T Abstract INTRODUCTION: Laparoscopic liver resection of segment seven (LLR-S7) is a technically challenging procedure due to its anatomical location and difficult accessibility. Herein, we present our experience with LLR-S7, and...
Tue Jul 21, 2020 14:19
Case report of bilateral testicular infarction due to severe bilateral epididymo-orchitis: A catastrophic complication causing castration. Int J Surg Case Rep. 2020 Jul 15;73:161-163 Authors: Ong Lay Keat W, Lechmiannandan S, Manoharan D, Lee SB, Nagalingam P Abstract INTRODUCTION: Testicular infarction as a result of severe epididymo-orchitis is an uncommon urological emergency, with only a handful of reported cases in literature. We report...
Tue Jul 21, 2020 14:19
Single incision laparoscopic approach for infected necrotizing pancreatitis: A case report. Int J Surg Case Rep. 2020 Jul 15;73:157-160 Authors: den Dekker N, Grüter AAJ, van Oostendorp SE, Zonderhuis BM, Tuynman JB Abstract INTRODUCTION: Approximately 5% of patients with acute pancreatitis develop infected necrotizing pancreatitis, with reported mortality rates up to 32%. Surgical interventions are postponed as long as possible, but if surgical...
Tue Jul 21, 2020 14:19
Spontaneous partial uterine laceration in primigravida at 16 weeks of gestation: A case report. Int J Surg Case Rep. 2020 Jul 15;73:154-156 Authors: Iino K, Tanaka K, Takabayashi A, Akaishi A, Ishihara K, Yokoyama Y Abstract INTRODUCTION: Although uterine rupture is well discussed, uterine laceration and partial myometrial laceration are little known. A previous report hypothesized that the stress of labor was associated with uterine laceration....
Tue Jul 21, 2020 14:19
An early presentation of a large calcified chronic subdural hematoma presenting as an inner eggshell in an elderly patient: A case report. Int J Surg Case Rep. 2020 Jul 15;73:150-153 Authors: Songnatsiri P, Ounahachok T, Atikankul T, Thananon J, Sookpotarom P Abstract INTRODUCTION: Calcified chronic subdural hematoma which is usually found in children and takes several months for calcification to be seen on imaging is presented in an elderly...
Tue Jul 21, 2020 14:19
Iatrogenic median nerve injury as a result of venous cut down procedure: A rare case report. Int J Surg Case Rep. 2020 Jul 15;73:146-149 Authors: Kansay R, Singhal A, Patil B, Malhotra A Abstract INTRODUCTION: Venous cut down is an emergency procedure done to get vascular access in trauma patients where peripheral cannulation/central venous catheter is challenging or causes delays. PRESENTATION OF CASE: We present a rare case of iatrogenic...
Tue Jul 21, 2020 14:19
MEN 2A syndrome - Multiple endocrine neoplasia with autosomal dominant transmission. Int J Surg Case Rep. 2020 Jul 15;73:141-145 Authors: Ungureanu S, Şipitco N, Alexa Z, Gonţa V, Bujac M, Parnov M, Romanenco R Abstract INTRODUCTION: Multiple endocrine neoplasias (MEN) are rare inherited syndromes. MEN type 2 syndromes occur in 1:30000 individuals, and are reported in approximately 500-1000 families worldwide, the most frequent being MEN 2A...
Tue Jul 21, 2020 14:19
Related Articles A multi-institutional randomized phase III trial comparing anatomical segmentectomy and wedge resection for clinical stage IA non-small cell lung cancer in high-risk operable patients: Japan Clinical Oncology Group Study JCOG1909 (ANSWER study). Jpn J Clin Oncol. 2020 Jul 20;: Authors: Shimoyama R, Tsutani Y, Wakabayashi M, Katayama H, Fukuda H, Suzuki K, Watanabe SI, Lung Cancer Surgical Study Group Abstract Anatomical segmentectomy...
Tue Jul 21, 2020 13:34
Related Articles Prognostic impact of the number of lateral pelvic lymph node metastases on rectal cancer. Jpn J Clin Oncol. 2020 Jul 20;: Authors: Ozawa H, Nakanishi H, Sakamoto J, Suzuki Y, Fujita S Abstract BACKGROUND: This study aimed to clarify the number of lateral pelvic lymph node metastases of colorectal cancer for which prognosis could be improved by dissection. METHODS: We analysed the data of 30 patients with lateral pelvic...
Tue Jul 21, 2020 13:34
Related Articles Adenomyosis as a Potential Risk Factor for Adverse Pregnancy Outcomes: A Multicenter Case-Control Study. Tohoku J Exp Med. 2020 07;251(3):231-239 Authors: Shinohara S, Okuda Y, Hirata S, Suzuki K Abstract As the number of women who postpone their first pregnancy until their late 30s or early 40s is increasing, adenomyosis is more frequently encountered by obstetricians. Some studies have reported on the relationship between...
Tue Jul 21, 2020 13:46
Related Articles Effectiveness of Hospital Discharge Support by Medical and Nursing Care Workers in Reducing Readmission Rates of Patients in Long-Term Care Wards: An Observation Study in Japan. Tohoku J Exp Med. 2020 07;251(3):225-230 Authors: Tsuboi H, Fujimori K Abstract For increasing medical care demand by aging population, the Japanese government is shifting to home medical care for treatments that do not necessarily require hospitalization....
Tue Jul 21, 2020 13:46
Related Articles Higher Density of Primary Care Facilities Is Inversely Associated with Ischemic Heart Disease Mortality, but Not with Stroke Mortality: A Japanese Secondary Medical Service Area Level Ecological Count Data. Tohoku J Exp Med. 2020 07;251(3):217-224 Authors: Saijo Y, Yoshioka E, Sato Y Abstract Poor accessibility to physicians might be linked to the inadequate control of cardiovascular risk factors. The aim of this study was to...
Tue Jul 21, 2020 13:46
Related Articles Letter to the Editor: Aerosol Box, An Operating Room Security Measure in COVID-19 Pandemic. World J Surg. 2020 Jul 19;: Authors: Walavalkar D, Y S R, Gangakhedkar GR PMID: 32686014 [PubMed - as supplied by publisher]
Tue Jul 21, 2020 16:32
UAE1 inhibition mediates the unfolded protein response, DNA damage and caspase-dependent cell death in pancreatic cancer. Transl Oncol. 2020 Jul 17;13(11):100834 Authors: Liu Y, Awadia S, Delaney A, Sitto M, Engelke C, Patel H, Calcaterra A, Zelenka-Wang S, Lee H, Contessa J, Neamati N, Ljungman M, Lawrence TS, Morgan MA, Rehemtulla A Abstract The Unfolded Protein Response (UPR) plays a key role in the adaptive response to loss of protein...
Tue Jul 21, 2020 13:52
Novel NHC-coordinated ruthenium(II) arene complexes achieve synergistic efficacy as safe and effective anticancer therapeutics. Eur J Med Chem. 2020 Jul 12;203:112605 Authors: Chen C, Xu C, Li T, Lu S, Luo F, Wang H Abstract There is an urgent need for more effective, less toxic cancer therapy agents. Motivated by this need, we synthesized a small panel of N-heterocyclic carbene (NHC)-coordinated ruthenium(II) arene complexes Ru1-Ru6 with...
Tue Jul 21, 2020 13:52
Related Articles CRISPR/Cas9 treatment causes extended TP53-dependent cell cycle arrest in human cells. Nucleic Acids Res. 2020 Jul 20;: Authors: Geisinger JM, Stearns T Abstract While the mechanism of CRISPR/Cas9 cleavage is understood, the basis for the large variation in mutant recovery for a given target sequence between cell lines is much less clear. We hypothesized that this variation may be due to differences in how the DNA damage...
Tue Jul 21, 2020 13:52
Related Articles Discovery of new fluorescent thiazole-pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells. Cell Death Dis. 2020 Jul 20;11(7):551 Authors: Lin Z, Wang Z, Zhou X, Zhang M, Gao D, Zhang L, Wang P, Chen Y, Lin Y, Zhao B, Miao J, Kong F Abstract A series of fluorescent thiazole-pyrazoline derivatives was synthesized and their structures were characterized by 1H NMR, 13C NMR,...
Tue Jul 21, 2020 13:52
Related Articles Effects of preparation method on the biochemical characterization and cytotoxic activity of New Zealand surf clam extracts. Heliyon. 2020 Jul;6(7):e04357 Authors: Odeleye T, Zeng Z, White WL, Wang KS, Li H, Xu X, Xu H, Li J, Ying T, Zhang B, Feng T, Lu J Abstract Molluscan extracts confer a wide range of health promoting properties, one of them is cytotoxicity. Extraction and processing can affect the efficacy and properties...
Tue Jul 21, 2020 13:52
Related Articles Overexpression of 14-3-3δ Predicts Poor Prognosis in Extrahepatic Cholangiocarcinoma Patients. Biomed Res Int. 2020;2020:8435420 Authors: Wu Q, Fan H, Lang R, Li X, Zhang X, Lv S, He Q Abstract The protein 14-3-3δ interacts with Trp53 to maintain G2 arrest and thus regulates the cell cycle. Though dysfunction of 14-3-3δ caused by hyper-methylation of CpG islands was reported in several carcinomas, the exact role of this...
Tue Jul 21, 2020 13:52
Related Articles Overexpression of 14-3-3σ Modulates Cholangiocarcinoma Cell Survival by PI3K/Akt Signaling. Biomed Res Int. 2020;2020:3740418 Authors: Wu Q, Fan H, Lang R, Li X, Zhang X, Lv S, He Q Abstract The protein 14-3-3σ is involved in numerous cellular processes through its ability to bind phosphorylated serine/threonine residues. It is a key regulator of the cell cycle involving in G2 arrest by p53. Deregulation of 14-3-3σ expression...
Tue Jul 21, 2020 13:52
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