Ornithine Decarboxylase Antizyme Pseudoknot RNA Binding to Spermine Regulates Gene Expression

Riboswitches are elements within messenger RNAs that directly bind to cellular metabolites and modulate gene expression through feedback regulation. Although riboswitches are widespread among bacteria, only one class further resides in fungi and plants, and no riboswitches have been found in animals. Here we propose the riboswitch function of a translational frame-shift stimulatory pseudoknot RNA (pkRNA) that is highly conserved among vertebrate ornithine decarboxylase antizyme (OAZ) genes involved in the regulation of polyamine biosynthesis.

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