Mechanistic Basis for Client Recognition and Amyloid Inhibition of NMNAT

Imbalance of proteostasis leads to abnormal protein aggregations as a common pathological hallmark in a variety of devastating human neurodegenerative diseases such as AD and PD. Chaperones play essential roles in maintaining proteostasis and preventing protein from abnormal aggregation. NMNAT, a NAD synthase firstly identified as a key protector in Wallerian axon degeneration, was recently found to possess chaperone activity and exhibits protective effects in cells and animal models of neurodegeneration.

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