Comprehensive analysis of immune, extracellular matrices and pathogens profile in lung granulomatosis of unexplained etiology

This study analyzed the Type 1 and Type 2T helper (Th-1/Th-2) cytokines (including interleukins), immune cellular, matrix profile and pathogens in granulomas with unexplained etiology and compared to infectious and non-infectious etiology. Surgical lung biopsies from 108 patients were retrospectively reviewed. Histochemistry, immunohistochemistry, immunofluorescence, morphometry and polymerase chain reaction (PCR) were employed, respectively, to evaluate total collagen and elastin fibers, collagen I and III, immune cells, cytokines, metalloproteinase-9 (MMP-9), myofibroblasts and multiple usual and unusual pathogens.

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