Microfluidic Tool for the Generation and Characterization of Lipid Gradients in Model Biomembranes

Many eukaryotic cells display distinct plasma membrane morphologies that depend on their life cycle and physiological conditions. These morphologies are often dynamic, show a high level of complexity and in some instances, give rise to polarized cells. We are interested in understanding how cells control micron scale polarization of membrane organization as seen during processes such as cytokinesis and chemotaxis or within statically polarized epithelial cells. Phosphoinositide gradients have been shown to be crucial for a range of important physiological events and it is our goal to explore how these gradients are created, maintained and reversed.

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