Neurodegenerative Loss of Mitochondrial Quality via the 18kDa Protein TSPO

The 18kDa Translocator Protein (TSPO), is a nuclear-encoded protein residing on the outer mitochondrial membrane and linked to a variety of pathological conditions. Traditionally a target of pharmacological agents, its ability to efficiently signal cellular stress has been employed in diagnostic protocols of neuroinflammation1. Recently, breakthroughs on its role in mitochondrial physiology and metabolism, including the negative regulation of mitophagy, have provided evidences for its mechanistic role as stress-response adaptive element in pathophyioslogy.

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