G Protein-GPCR Interaction Studied by SANS

G protein-coupled membrane receptors (GPCR) transmit extracellular signals elicited by compounds like neural transmitters, hormones, odorants, or light to the cell interior, where they activate GTP-binding proteins (G proteins). It is desirable to study GPCR and G protein under functional conditions in their natural environment, namely a fluid lipid matrix. Experiments were conducted using the GPCR bovine rhodopsin and the G protein transducin. We have recently shown that SANS is capable of measuring the state of GPCR homo-oligomerization in a lipid matrix under functional conditions.

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