Differential Association of Adenylyl Cyclase Isoforms with Membrane Microdomains Regulates cAMP Compartmentation in Human Airway Smooth Muscle Cells

Compartmentation of cAMP signaling is critical to explaining how different G-protein coupled receptors produce distinct responses within the same cell. Membrane microdomains have been suggested to play an important role by forming discrete receptor-specific signaling complexes. Key components include various isoforms of the cAMP producing enzyme adenylyl cyclase (AC). In human airway smooth muscle (HASM) cells, AC6 is preferentially found in caveolar/lipid raft membrane domains while AC2 is found in non-raft domains.

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