Telomerase reverse transcriptase rs2736098 polymorphism is associated with lung cancer: A meta-analysis

Telomerase reverse transcriptase rs2736098 polymorphism is associated with lung cancer: A meta-analysis: Journal of International Medical Research, Volume 48, Issue 10, October 2020.

BackgroundA meta-analysis was conducted to determine whether telomerase reverse transcriptase (TERT) rs2736098 polymorphism was related to the incidence of lung cancer.MethodsWe systematically searched the following three electronic databases: PubMed, Embase, and China National Knowledge Infrastructure (CNKI), for relevant articles. Statistical analysis was performed using the odds ratio (OR) and the corresponding 95% confidence interval (CI).ResultsSeven articles involving 3836 healthy controls and 3637 patients were included in this meta-analysis. TERT rs2736098 polymorphism was significantly related to lung cancer incidence (AA vs. GG: OR=1.83, 95% CI=1.58–2.12; AG vs. GG: OR=1.21, 95% CI=1.10–1.34; Dominant model: OR=1.33, 95% CI=1.22–1.46; Recessive model: OR=1.66, 95% CI=1.44–1.90). Moreover, this polymorphism was found to be correlated with the susceptibility to lung cancer when studies were stratified based on the sample size and the Hardy–Weinberg equilibrium.ConclusionThe present findings indicate that the TERT rs2736098 polymorphism may be a risk factor for the development of lung cancer.