Publication date: Available online 11 October 2020Source: Behavioural Brain ResearchAuthor(s): Tian Tian, Jia Li, Guiling Zhang, Jian Wang, Dong Liu, Changhua Wan, Jicheng Fang, Di Wu, Yiran Zhou, Wenzhen Zhu
Mon Oct 12, 2020 19:44
Abstract Myeloid cells are an inherent part of the microenvironment of glioblastoma multiforme (GBM). There is growing evidence for their participation in mechanisms of tumor escape, especially in development of resistance following initially promising anti‐VEGF/VEGFR treatment. Thus, we sought to define the capability of myeloid cells to contribute to the expression of proangiogenic molecules in human GBM. We investigated GBM specimens in comparison to anaplastic astrocytoma (WHO grade III) and...
Mon Oct 12, 2020 18:46
Abstract SETDB1 is a histone lysine methyltransferase that has critical roles in cancers. However, its potential role in gastric cancer (GC) remains obscure. Here, we mainly investigate the clinical significance and the possible role of SETDB1 in GC. We find that SETDB1 expression is upregulated in GC tissues and its high‐level expression was a predictor of poor prognosis in patients. Overexpression of SETDB1 promoted cell proliferation and metastasis, while SETDB1 suppression had an opposite effect...
Mon Oct 12, 2020 18:46
Abstract Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) was suggested as an entity separate from other types of Hodgkin lymphoma 40 years ago and recognized in the WHO classification in 2001. Based on its relatively benign course with late distant relapses, relation with lymph node hyperplasia with progressively transformed germinal centers, presence of clonal immunoglobulin gene rearrangements with somatic hypermutations and ongoing mutations, and relation with a number of inherited defects...
Mon Oct 12, 2020 18:39
Primary Intraosseous Squamous Cell Carcinoma Involving the Jaw Bones: A Systematic Review and Update
Abstract Primary intraosseous oral squamous cell carcinoma (PIOSCC) is a rare malignant neoplasm that affects the jaws. Despite its aggressive biological behavior, there are no studies that evaluated the clinicopathological features of this tumor and parameters associated with its prognosis. The objective of the present study was to conduct a systematic review of the available data on oral and maxillofacial PIOSCC in order to determine its clinicopathological characteristics and...
Mon Oct 12, 2020 03:00
Abstract Tracheocele is a herniation of the tracheal mucosa through a defect in the tracheal wall. Familiar and/or genetical factors have never been taken into consideration in the etiopathogenesis of acquired tracheocele. Acquired tracheocele occurred in a brother and a sister from India. CT scan of the neck showed an air cyst next to the right tracheal wall. They underwent surgical excision through a transverse cervical incision. Histopathology of the lesion revealed a fibrous...
Mon Oct 12, 2020 03:00
Abstract Salivary gland tumors (SGT) represent an uncommon heterogeneous group of tumors with complex clinical and pathological characteristics. The prevalence of these lesions varies between studies but has been estimated between 3 and 6% of all tumors in the head and neck region. The present study aimed to evaluate the distribution and demographic findings of salivary gland tumors diagnosed in an oral pathology service in Mexico. A retrospective descriptive cross-sectional study...
Mon Oct 12, 2020 03:00
Objectives. The aim of this study was to investigate the role of ESR1 rs1643821 and TNF-α rs1800629 as potential genetic factors regulating anterior disc displacement without reduction-mediated inflammatory pathway. Background. The temporomandibular joint is a complex synovial joint that allows mandibular movement in three directions. Although temporomandibular disorders are widespread, limited data is available on the biochemical characteristics of the displaced disc and quality of the surrounding...
Mon Oct 12, 2020 14:20
Publication date: Available online 11 October 2020Source: Radiotherapy and OncologyAuthor(s): Dongdong Yu, Weiguo Hu, Lulu Chen, Zhenming Fu, Qibin Song, Xiangpan Li
Mon Oct 12, 2020 19:19
Publication date: Available online 12 October 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Ting GU, Chunye ZHANG, Ronghui XIA, Yuhua HU, Zhen TIAN, Jiang LI
Mon Oct 12, 2020 18:28
Publication date: Available online 12 October 2020Source: Medical HypothesesAuthor(s): Silvano Traverso
Mon Oct 12, 2020 18:00
Abstract Adenomatous neuroendocrine tumors of the middle ear (MEANTs) are very rare neoplasms which are composed of both epithelial and neuroendocrine components. They have mostly bland histology and indolent biological behavior, yet they may recur and metastasize. Here we present a case of MEANT with ipsilateral local brain, bone and nerve invasion and bilateral cervical lymphadenopathy in a 48 years old male with history of recurrent chronic otitis media and cholesteatoma. The patient underwent...
Mon Oct 12, 2020 15:49
Abstract Introduction Cerebral spinal fluid (CSF) cytomorphologic analysis remains the gold standard in the evaluation of malignant leptomeningeal involvement. However, collection of optimal volumes for adequate cytomorphologic evaluation is not standardized. Our study investigated optimal CSF volumes that result in a significant diagnostic result. Methods A total of 4114 samples were retrospectively identified from 2014 to 2018, and 2557 samples had concurrent flow cytometry (FC) study....
Mon Oct 12, 2020 15:45
Abstract Molluscum contagiosum (MC) is a common cutaneous viral infection with no standard treatment. The virus responsible for MC is thought to be cleared by cell mediated immunity (CMI). Intralesional immunotherapy that stimulates CMI has been shown to be an effective treatment for other cutaneous viruses. In this review, we evaluate the efficacy and safety of intralesional immunotherapy in the treatment of MC. Articles met inclusion criteria if they examined the effects of intralesional immunotherapy...
Mon Oct 12, 2020 15:20
Abstract Intralesional methotrexate (IL‐MTX) is a long‐established treatment, which is arguablyunderutilized by dermatologists. We describe the underlying evidence base and practical considerations for its broad range of cutaneous indications,including in cutaneous oncology (keratoacanthomas, squamous cell carcinomas, lymphomas), inflammatory dermatology (nail psoriasis, plaque psoriasis, pyoderma gangrenosum, cutaneous Crohn’s disease, amyloidosis), cutaneous infections (viral warts) and for treatment...
Mon Oct 12, 2020 14:31
Publication date: Available online 12 October 2020Source: BrachytherapyAuthor(s): Brian J. Moran, Antony Koroulakis, Cristina Decesaris, Michelle H. Braccioforte, Neha Amin, Manuj Agarwal
Mon Oct 12, 2020 17:42
Introduction: Association between hypercalcitoninemia and pathological conditions such as autoimmune thyroiditis (AIT) or differentiated thyroid carcinoma (DTC) has been addressed, with conflicting results. We evaluated the prevalence and the clinical relevance of elevated basal serum calcitonin (CT) levels in non-neoplastic (nodular goiter [NG] and AIT) and neoplastic thyroid diseases (DTC). Methods: We retrospectively evaluated 3,250 consecutive patients with thyroid nodular disease who underwent...
Mon Oct 12, 2020 14:54
Abstract Chiari 1.5 malformation (C1.5) is a rare condition characterized by caudal descent of the brain stem, together with descent of the cerebellar tonsils characteristic of Chiari I malformation (CIM). Syringobulbia (SB) is rarely associated with CIM and to date has not been reported in a patient with C1.5. An adolescent female presented with Valsalva-induced headaches and a left abducens nerve palsy. Imaging revealed C1.5 and a huge syringomyelia extending cranially into...
Mon Oct 12, 2020 03:00
Abstract Background Epilepsy is a common neurological disease that has a negative impact on physical, social, and cognitive function. Seizure-induced neuronal injury is one of the suggested mechanisms of epilepsy complications. We aimed to evaluate the circulating level of glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) as markers of neuronal damage in children with epilepsy and its relation...
Mon Oct 12, 2020 03:00
Purpose of review This review describes how plasma is sourced for fractionation into plasma-derived medicinal products (PDMPs), such as immunoglobulin (Ig) together with differences between plasma from whole blood (recovered plasma) and from plasmapheresis (source plasma) in terms of global plasma supply. Specific areas of growth in immunoglobulin use are identified alongside novel therapies, which may reduce demand for some immunoglobulin indications. Recent findings There has been a 6--8%...
Fri Oct 09, 2020 03:00
Purpose of review Transplantation of cultured postnatal allogeneic thymus has been successful for treating athymia, mostly associated with complete DiGeorge syndrome, for more than 20 years. Advances in molecular genetics provide opportunities for widening the range of athymic conditions that can be treated while advances in cell culture and organ/tissue regeneration may offer the prospect of alternative preparations of thymic tissue. There are potential broader applications of this treatment...
Fri Oct 09, 2020 03:00
Purpose of review The purpose of this article is to provide an overview of the literature pertaining to the use of allergen immunotherapy for treatment of allergic conjunctivitis with an emphasis on recent developments. Recent findings Both subcutaneous (SCIT) and sublingual (SLIT) immunotherapy continue to show efficacy in treating allergic conjunctival disease, subcutaneous more than sublingual. Adverse effects of sublingual therapy continue to be reported since the FDA's approval of SLIT...
Fri Oct 09, 2020 03:00
Purpose of the review The aim of this article is to summarize recent data on rubella virus (RuV) vaccine in chronic inflammation focusing on granulomas in individuals with primary immunodeficiencies (PIDs). Recent findings The live attenuated RuV vaccine has been recently associated with cutaneous and visceral granulomas in children with various PIDs. RuV vaccine strain can persist for decades subclinically in currently unknown body site(s) before emerging in granulomas. Histologically, RuV...
Fri Oct 09, 2020 03:00
Publication date: Available online 11 October 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Leila Shahmoradi, Sohrab Almasi, Hossein Ahmadi, Azadeh Bashiri, Tania Azadi, Alireza Mirbagherie, Noureddin Nakhostin Ansari, Roshanak Honarpishe
Mon Oct 12, 2020 17:21
Publication date: Available online 11 October 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): A. Gangwar, D. Singh
Mon Oct 12, 2020 16:45
Publication date: Available online 11 October 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): Z. Zhang, P. Zhang, S. Li, J. Cheng, H. Yuan, H. Jiang
Mon Oct 12, 2020 16:45
Comparison of patients satisfaction with aesthetic outcomes following lower extremity reconstruction: Muscle vs. fasciocutaneous free flaps. J Plast Reconstr Aesthet Surg. 2020 Sep 20;: Authors: Seyidova N, Anderson K, Abood A Abstract BACKGROUND: The microsurgical reconstruction of complex lower limb defects has become a routine procedure with high success rates. The emphasis has changed from ensuring flap 'success' to providing a reconstruction,...
Mon Oct 12, 2020 16:39
Assessment of long-term quality of life in patients with syndromic craniosynostosis. J Plast Reconstr Aesthet Surg. 2020 Sep 19;: Authors: Sakamoto Y, Takenouchi T, Miwa T, Kishi K Abstract Several studies have analyzed the long-term stability of cranioplasty and midface distraction in patients with craniosynostosis; however, few studies have investigated long-term quality of life (QOL) and complications in adults with syndromic craniosynostosis....
Mon Oct 12, 2020 16:39
From chaos to a new norm: The Birmingham experience of restructuring the largest plastics department in the UK in response to the COVID-19 pandemic. J Plast Reconstr Aesthet Surg. 2020 Sep 20;: Authors: Leng C, Challoner T, Hausien O, Filobbos G, Baden J Abstract The coronavirus disease 2019 (COVID-19) pandemic presented unprecedented challenges for healthcare systems worldwide. The Queen Elizabeth Hospital, Birmingham, has one of the largest...
Mon Oct 12, 2020 16:39
The shifting demographics of birth-related brachial plexus injury: The impact of socio-economic status and ethnic groups. J Plast Reconstr Aesthet Surg. 2020 Sep 10;: Authors: Merrison H, Mangtani A, Quick T Abstract INTRODUCTION: Many of the risk factors for birth-related brachial plexus injury (BRBPI), such as maternal gestational diabetes and macrosomia, are known to vary between demographic groups. Socio-economic differences are known to...
Mon Oct 12, 2020 16:39
Looking ahead to a trauma service with COVID-19. J Plast Reconstr Aesthet Surg. 2020 Sep 28;: Authors: Mason J, West E, Jackson P PMID: 33039305 [PubMed - as supplied by publisher]
Mon Oct 12, 2020 16:39
Predicting risk factors that lead to free flap failure and vascular compromise: A single unit experience with 565 free tissue transfers. J Plast Reconstr Aesthet Surg. 2020 Sep 20;: Authors: Lese I, Biedermann R, Constantinescu M, Grobbelaar AO, Olariu R Abstract BACKGROUND: Even though the benefit of free tissue transfer is uncontested in complex reconstructive cases, vascular compromise and/or flap failure remain a challenge for the surgeon...
Mon Oct 12, 2020 16:39
Response to "Re "Impact of MSLT-II on lymph node clearance surgery in a tertiary plastic surgery centre"". J Plast Reconstr Aesthet Surg. 2020 Sep 28;: Authors: Misky AT, Sadr AH, Nikkhah D PMID: 33039303 [PubMed - as supplied by publisher]
Mon Oct 12, 2020 16:39
Editorial - In memory of Ian Jackson. J Plast Reconstr Aesthet Surg. 2020 Oct;73(10):1787 Authors: PMID: 33039093 [PubMed - as supplied by publisher]
Mon Oct 12, 2020 16:39
Publication date: Available online 12 October 2020Source: World NeurosurgeryAuthor(s): Yu-Jie Yang, Xin Huang, Xiao-Ning Gao, Bing Xia, Jian-Bo Gao, Chen Wang, Xiao-Ling Zhu, Xiao-Juan Shi, Hui-Ren Tao, Zhuo-Jing Luo, Jing-Hui Huang
Mon Oct 12, 2020 16:37
Diaphragmatic Lipoma in a Woman with Rheumatoid Arthritis: A Case Report and Literature Review. Am J Case Rep. 2020 Oct 11;21:e925174 Authors: Alawneh KZ, Raffee LA, Alawneh KM, Alawneh H, Aleshawi A Abstract BACKGROUND A lipoma is a benign tumor made of fat tissue. Diaphragmatic lipomas are frequently reported in case studies. CASE REPORT This study presents a case of diaphragmatic lipoma in a woman with rheumatoid arthritis who was complaining...
Mon Oct 12, 2020 16:35
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:To study the specific expression of circular RNA (circRNA) in breast cancer and adjacent normal tissues to identify differentially expressed circRNA in breast cancer patients. To study the correlation between circRNA and clinical data of breast cancer, and to evaluate its potential as a breast cancer biomarker.Methods:The differential expression of circRNAs between the breast cancer tissues and adjacent...
Mon Oct 12, 2020 12:33
Abstract Background There is an increasing public interest in the use of TM internationally, yet there is a paucity of research on the use of TM by the public in the dental setting. This study aimed to explore the views, use of and access to TM in dentistry among different ethnic groups residing in New Zealand. Methods Qualitative study...
Mon Oct 12, 2020 03:00
Abstract Background Pulpitis is an inflammatory disease, the grade of which is classified according to the level of inflammation. Traditional methods of evaluating the status of dental pulp tissue in clinical practice have limitations. The rapid and accurate diagnosis of pulpitis is essential for determining the appropriate treatment. By integrating different datasets from the Gene Expression Omnibus (GEO) database, we analysed...
Mon Oct 12, 2020 03:00
Publication date: Available online 11 October 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Alessandra Laís Pinho Valente Pires, Juliana Araújo da Silva Simoura, Joana Dourado Martins Cerqueira, Ynara Bosco de Oliveira Lima-Arsati, Franco Arsati, Jean Nunes dos Santos, Valéria Souza Freitas
Mon Oct 12, 2020 16:23
Objective To assess the current practices and challenges of training office‐based procedures to laryngology fellows in the United States. Methods An anonymous web‐based survey study was distributed to laryngology fellowship program directors, as listed by the American Laryngological Association. The survey was a 19‐item questionnaire with free‐text, Likert scale, and multiple‐choice answers. Results Twenty‐two of 27 program directors (81.4%) replied to the survey. Many programs (8/16)...
Mon Oct 12, 2020 14:31
Objective No surgical or radiotherapeutic treatment guidelines exist for oligometastatic head and neck squamous cell carcinoma (oHNSCC), and only recently have interventions with curative intent been studied. Herein, we sought to elucidate survival rates among patients with oHNSCC to determine if treatment with curative intent is warranted in this population. Study Design Retrospective chart review. Methods We retrospectively reviewed cases of oHNSCC treated between March 1998 and March...
Mon Oct 12, 2020 14:28
Mon Oct 12, 2020 12:17
Mon Oct 12, 2020 11:02
Mon Oct 12, 2020 11:02
No abstract available
Thu Oct 08, 2020 03:00
No abstract available
Thu Oct 08, 2020 03:00
No abstract available
Thu Oct 08, 2020 03:00
No abstract available
Thu Oct 08, 2020 03:00
Conditions: Biliary Tract Neoplasms; Gastric Cancer; Esophageal Squamous Cell Carcinoma; Colorectal Cancer; Gastrointestinal Stromal Tumors; Pancreatic Cancer; Neuroendocrine Tumors; Unknown Primary Cancer; Digestive CancerInterventions: Drug: FGFR Inhibitor, IDH1 Inhibitor, HER2 Inhibitor, PARP Inhibitor, BRAF Inhibitor, MEK Inhibitor, ICIs, EGFR-TKIs, NTRK-TKI, and et. al.; Drug: Other TherapySponsors: Peking University; Hangzhou DIAN Medical Diagnostic Center Co.,...
Mon Oct 12, 2020 16:02
Condition: Cervical DystoniaIntervention: Drug: Neuronox ® InjectionSponsor: Rajavithi HospitalRecruiting
Mon Oct 12, 2020 16:02
Condition: Anesthesia, LocalIntervention: Drug: LidocainSponsor: Kfir SiagNot yet recruiting
Mon Oct 12, 2020 16:02
Condition: Paraganglioma of Head and NeckIntervention: Diagnostic Test: 1H-Spectroscopy MRISponsors: Assistance Publique - Hôpitaux de Paris; Society for EndocrinologyNot yet recruiting
Mon Oct 12, 2020 16:02
Condition: XerostomiaIntervention: Device: sialendoscopySponsor: Groupe Hospitalier Paris Saint JosephNot yet recruiting
Mon Oct 12, 2020 16:02
Background: Professional and consistent smoking prevention and cessation may avoid many smoking-associated deaths worldwide. Dentists can exert a decisive influence on smoking behavior, as most people regularly visit a dentist. However, only if dentists have been trained sufficiently about the consequences of smoking and of smoking cessation methods might they fulfill this task appropriately. Objectives: The aim of our study was therefore to examine the prevalence of smokers among dental students...
Mon Oct 12, 2020 15:03
Publication date: Available online 11 October 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Motoharu Sasaki, Hitoshi Ikushima, Akira Tsuzuki, Wataru Sugimoto
Mon Oct 12, 2020 15:46
Publication date: Available online 11 October 2020Source: Brain Research BulletinAuthor(s): Praveen Kulkarni, Mansi R Bhosle, Shi-fang Lu, Neal S Simon, Sade Iriah, Michael J. Brownstein, Craig F Ferris
Mon Oct 12, 2020 15:47
The difference between vervet monkey core body and dorsal surface temperatures. Temperature differences in excess of 15°C were common and occasionally exceeded 20°C at low temperatures. Abstract Understanding the physiological processes that underpin primate performance is key if we are to assess how a primate might respond when navigating new and changing environments. Given the connection between a mammal's ability to thermoregulate and the changing demands of its thermal environment, increasing...
Sun Oct 11, 2020 21:17
Abstract The current paradigm of conservation initiatives promotes activities that benefit conservation of wildlife while at the same time improving the welfare of humans living near wildlife habitats. This dual focus of conservation has resulted in an increase in activities that engage local communities. The past decade has seen a shift in how conservation practitioners define the role of conservation education. While once limited to a focus on increasing knowledge and influencing attitudes and...
Sun Oct 11, 2020 21:15
Abstract The benefit of transurethral laser prostatectomy over open simple prostatectomy (OSP) is controversial in aged symptomatic benign prostatic hyperplasia (BPH) patients with large volume prostates, and the aim of this study is to compare the safety and efficiency of these two methods. Meta-analysis was applied using the Review Manager V5.3 software and the retrieved randomized controlled clinical trials (RCTs) comparing transurethral laser prostatectomy with OSP were analyzed...
Mon Oct 12, 2020 03:00
Re-expression of DIRAS3 and p53 induces apoptosis and impaired autophagy in head and neck squamous cell carcinoma. Mil Med Res. 2020 Oct 11;7(1):48 Authors: Liu Z, Hurst DR, Qu X, Lu LG, Wu CZ, Li YY, Li Y Abstract BACKGROUND: p53 and DIRAS3 are tumor suppressors that are frequently silenced in tumors. In this study, we sought to determine whether the concurrent re-expression of p53 and DIRAS3 could effectively induce head and neck squamous...
Mon Oct 12, 2020 15:38
The correlation between drug-induced sleep endoscopy findings and severity of obstructive sleep apnea. Auris Nasus Larynx. 2020 Oct 07;: Authors: Hsu YB, Lan MY, Huang YC, Huang TT, Lan MC Abstract OBJECTIVE: This study aimed to assess the relationship between anthropometric data, drug-induced sleep endoscopy (DISE) findings, and severity of obstructive sleep apnea (OSA). METHODS: From August 2016 to August 2017, a total of 147 surgically...
Mon Oct 12, 2020 15:30
Optimal current intensity for supramaximal stimulation during electroneurography for facial palsy. Auris Nasus Larynx. 2020 Oct 07;: Authors: Ayani Y, Haginomori SI, Wada SI, Nakano H, Inaka Y, Ozaki A, Ichihara T, Inui T, Kawata R Abstract OBJECTIVE: To determine the optimal current intensity for supramaximal stimulation during electroneurography (ENoG) for facial palsy. METHODS: Forty patients with unilateral facial palsy (32 Bell's...
Mon Oct 12, 2020 15:30
Cochlear implantation in an animal model documents cochlear damage at the tip of the implant. Braz J Otorhinolaryngol. 2020 Sep 20;: Authors: Andrade JSC, Baumhoff P, Cruz OLM, Lenarz T, Kral A Abstract INTRODUCTION: Electrocochleography has recently emerged as a diagnostic tool in cochlear implant surgery, purposing hearing preservation and optimal electrode positioning. OBJECTIVE: In this experimental study, extra-cochlear potentials...
Mon Oct 12, 2020 15:15
[Complementary and alternative medicine in cancer patients and randomized controlled trials]. Bull Cancer. 2020 Oct 07;: Authors: Murat-Ringot A, Preau M, Piriou V Abstract More and more cancer patients around the world are using complementary and alternative medicine. They are mostly used as a complement to conventional care in decreasing the side effects of treatment and improving their quality of life. However, patients often use them without...
Mon Oct 12, 2020 14:44
[CD34+ cell selection methods, quality controls and expected results: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)]. Bull Cancer. 2020 Oct 07;: Authors: Calmels B, Gautier É, Magnani A, Magrin É, Mamez AC, Vaissié A, Yakoub-Agha I, Baudoux É Abstract CD34+ immunomagnetic positive selection allows for CD34+ hematopoietic progenitors separation from CD3+ lymphocytes subsets, usually from...
Mon Oct 12, 2020 14:44
[Fundamental aspects of oncogenesis]. Bull Cancer. 2020 Oct 07;: Authors: Lemaire J, Larrue R, Perrais M, Cauffiez C, Pottier N Abstract Tumorigenesis has traditionally been considered as a multi-step process involving the activation of oncogenes as well as the inactivation of tumor suppressor genes. However, the mechanisms driving cancer initiation and progression are not restricted to molecular alterations and instead should be viewed as...
Mon Oct 12, 2020 14:44
Overexpression of RAD50 is the Marker of Poor Prognosis and Drug Resistance in Breast Cancer Patients. Curr Cancer Drug Targets. 2020 Oct 09;: Authors: Karamat U, Ejaz S Abstract BACKGROUND: The prevalence of breast cancer is increasing at an alarming rate and thus demands exploration of most relevant diagnostic biomarkers. RAD50 is a cancer susceptibility gene which encodes a DNA damage repairing protein. Its role in breast cancer as clinico-pathological...
Mon Oct 12, 2020 14:28
Tyrosine Kinase Inhibitors (TKIs) in Lung Cancer Treatment: a Comprehensive Analysis. Curr Cancer Drug Targets. 2020 Oct 09;: Authors: Murugesan S, Murugesan J, Palaniappan S, Palaniappan S, Murugan T, Siddiqui SS, Loganathan S Abstract Lung cancer is the leading type of cancer worldwide today. Kinases play a crucial role in mediating the signaling pathways and it directs to control several necessary cellular processes. Conversely, deregulation...
Mon Oct 12, 2020 14:28
Hepatic vascular variations and visual three-dimensional reconstruction technique in pediatric patients with choledochal cyst. Surg Radiol Anat. 2020 Oct 11;: Authors: Chen W, Zhao L, Wang J, Guo WL Abstract PURPOSE: The aim of the present study was to identify the hepatic vascular variations with visual three-dimensional (3D) reconstruction of vessels in pediatric patients with choledochal cyst (CDC). METHODS: We retrospectively...
Mon Oct 12, 2020 14:26
High‐resolution manometry (HRM) maneuvers, multiple rapid swallows and rapid drink challenge, helped identify patients with retention on barium esophagram among patients classified as esophagogastric junction outflow obstruction (EGJOO) on HRM; thus these test maneuvers may be helpful in differentiating clinically relevant EGJOO from misleading pressure artifact. Abstract Background Esophagogastric junction outflow obstruction (EGJOO) as defined by Chicago Classification of esophageal...
Sun Oct 11, 2020 21:15
Abstract Hypercontractile esophagus (HE), also known as jackhammer esophagus, is an esophageal motility disorder. Nowadays, high‐resolution manometry (HRM) is used to diagnose the disorder. According to the latest iteration of the Chicago classification, HE is present when at least 2 out 10 liquid swallow‐induced peristaltic waves have an abnormally high Distal Contractile Integral. In the era of conventional manometry, a similar condition, referred to as nutcracker esophagus, was diagnosed when...
Sun Oct 11, 2020 19:10
Pericarditis with cardiac tamponade - A misleading complication of appendicitis: A rare case report.
Pericarditis with cardiac tamponade - A misleading complication of appendicitis: A rare case report. Int J Surg Case Rep. 2020 Sep 23;76:207-209 Authors: Wójcik A, Skorek P, Palczewska D, Weryński P Abstract INTRODUCTION: As severe complication of appendicitis as effusive pericarditis is a rare phenomenon. Taking into consideration open access data in a 50-year period we perceived three pediatric cases with pericarditis as a complication of...
Mon Oct 12, 2020 14:21
A case of endovascular therapy for treating idiopathic arterial deteriorations of unknown etiology. Int J Surg Case Rep. 2020 Sep 30;76:202-206 Authors: Matsuura S, Takayama T, Endo T, Akai T, Isaji T, Hoshina K Abstract INTRODUCTION: Peripheral artery pseudoaneurysm as a consequence of arterial deterioration is relatively rare in young populations, who typically lack an atherosclerotic background. Such pseudoaneurysms are known to pose a risk...
Mon Oct 12, 2020 14:21
Necrotizing Fasciitis: Expect the unexpected. Int J Surg Case Rep. 2020 Sep 24;76:199-201 Authors: Khalid M, Dattani M, Bowley D Abstract INTRODUCTION: Necrotizing fasciitis is a rapidly progressive and potentially fatal soft tissue infection. A wide spectrum of aerobic and nonaerobic organisms has been implicated as the causative pathogen. Necrotizing Fasciitis due to Salmonella serovars have previously been implicated both with and without...
Mon Oct 12, 2020 14:21
Bellini duct carcinoma revealed by cutaneous metastasis: A case report. Int J Surg Case Rep. 2020 Sep 28;76:195-198 Authors: Oueslati A, Saadi A, Chakroun M, Zaghbib S, Blel A, Ksentini M, Bouzouita A, Derouiche A, Ben Slama MR, Rammeh S, Ayed H, Chebil M Abstract INTRODUCTION: Cutaneous metastasis of renal cell carcinoma is rare and the majority of these metastases are asynchronous. The scalp and face are the major sites of metastases, followed...
Mon Oct 12, 2020 14:21
Tornwaldt nasopharyngeal cyst: Case series and literature review. Int J Surg Case Rep. 2020 Sep 21;76:166-169 Authors: Alshuhayb Z, Alkhamis H, Aldossary M, Almoumen Z, Aldhurais A, Alshuhayb B, Almomen A Abstract BACKGROUND: Tornwaldt cyst (TC) is a relatively rare but benign disease. Although these lesions are asymptomatic and found incidentally during routine ENT examination, the can present with unexplained sinonasal symptoms, such as nasal...
Mon Oct 12, 2020 14:21
Unexpected finding of urachal remnant cyst. Tips for laparoscopic approach. Int J Surg Case Rep. 2020 Sep 11;: Authors: Calagna G, Rotolo S, Catinella V, Maranto M, Carlisi B, Bisso C, Venezia R, Mangione D, Cucinella G Abstract INTRODUCTION: Incomplete obliteration of the urachal lumen could cause different types of anomalies and urachal cyst is the most common among these in the adult population. It is usually asymptomatic and may be an incidental...
Mon Oct 12, 2020 14:21
Five Specific Tongue Movements in a Healthy Population. Dysphagia. 2020 Oct 11;: Authors: Kappert KDR, van Dijk S, Wellenstein D, van Alphen MJA, van Son RJJH, Smeele LE, Balm AJM Abstract The importance of tongue mobility on speech, oral food transport, and swallowing is well recognized. However, whether the individual tongue mobility influences postoperative function in oral cancer treatment remains to be elucidated. This study assesses the...
Mon Oct 12, 2020 14:16
Anticancer drug synergy prediction in understudied tissues using transfer learning. J Am Med Inform Assoc. 2020 Oct 11;: Authors: Kim Y, Zheng S, Tang J, Jim Zheng W, Li Z, Jiang X Abstract OBJECTIVE: Drug combination screening has advantages in identifying cancer treatment options with higher efficacy without degradation in terms of safety. A key challenge is that the accumulated number of observations in in-vitro drug responses varies greatly...
Mon Oct 12, 2020 14:16
Outcomes Following Extracorporeal Photopheresis for Chronic Lung Allograft Dysfunction Following Lung Transplantation: A Single-Center Experience. Transplant Proc. 2020 Oct 07;: Authors: Vazirani J, Routledge D, Snell GI, Watson D, Paraskeva M, Westall GP, Harrison SJ Abstract INTRODUCTION: Survival following lung transplantation (LTx) is limited by the development of chronic lung allograft dysfunction (CLAD), for which there are few effective...
Mon Oct 12, 2020 14:16
The nasal septum is a heterogeneous cartilage with differential location‐dependent growth characteristics. Hypertrophic chondrocytes are found throughout the septum, although endochondral ossification is restricted to the posterior region. Columnar and hypertrophic chondrocytes are not sequentially organized as in growth plates. Hypertrophy appears to be a significant component in septum growth. Osteocalcin may reflect metabolic requirements rather than a particular chondrocyte maturation stage....
Mon Oct 12, 2020 13:28
CT‐scans of the vertebra of Nothronychus graffami reveal an intermediate structure between more basal theropods and birds. Uni‐directional airflow as in birds is supported, but this trait does not necessarily imply endothermy. Abstract Nothronychus was a large, derived therizinosaur from the Upper Cretaceous of Utah and New Mexico. The genus is known from elements that have been referred to single individuals. Therizinosaurs were unusual maniraptoran theropods close to the origin of birds....
Mon Oct 12, 2020 13:21
COVID-19 safety: aerosol-generating procedures and cardiothoracic surgery and anaesthesia - Australian and New Zealand consensus statement. Med J Aust. 2020 Oct 11;: Authors: Irons JF, Pavey W, Bennetts JS, Granger E, Tutungi E, Almeida A Abstract INTRODUCTION: Coronavirus disease 2019 (COVID-19) is a contagious disease that is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Health care workers are at risk of...
Mon Oct 12, 2020 14:09
Co-inections of domestic and wild birds with avian influenza and Newcastle disease viruses: implications for control and genetic mutations. Vet Res Commun. 2020 Oct 10;: Authors: Musa WI, Sa'idu L, Bello M, Abdu PA Abstract Co-infections of birds' upper respiratory tract by avian pathogens are common and cause increasing economic losses. This study determines co-infection status of avian influenza (AI) and Newcastle disease (ND) in birds...
Mon Oct 12, 2020 14:09
High prevalence of carbapenem-resistant Acinetobacter baumannii associated respiratory tract infections in Pakistani hospitals. J Pak Med Assoc. 2020 Sep;70(9):1630-1632 Authors: Khalid F, Saleem S, Ahmad I Abstract Acinetobacter baumannii is one of the most common causes of nosocomial infections in developing countries. It has a better ability to get antimicrobial resistance due to plasticity in genome. The recent emergence of carbapenem-resistant...
Mon Oct 12, 2020 14:09
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