High prevalence of carbapenem-resistant Acinetobacter baumannii associated respiratory tract infections in Pakistani hospitals. J Pak Med Assoc. 2020 Sep;70(9):1630-1632 Authors: Khalid F, Saleem S, Ahmad I Abstract Acinetobacter baumannii is one of the most common causes of nosocomial infections in developing countries. It has a better ability to get antimicrobial resistance due to plasticity in genome. The recent emergence of carbapenem-resistant...
Mon Oct 12, 2020 14:09
Reduced SARS-CoV-2 entry factors and enhanced innate immune gene expression in the nasal epithelium of pregnant rats. Am J Obstet Gynecol. 2020 Oct 08;: Authors: Palanisamy A, Giri T Abstract OBJECTIVE: An enigmatic epidemiological feature of the ongoing COVID-19 pandemic is the high rate of asymptomatic infection in pregnant women.1 This is puzzling because systemic immune changes predispose pregnant women to increased severity of respiratory...
Mon Oct 12, 2020 14:09
Multidrug-resistant Staphylococcus aureus nasal carriage among HIV-positive outpatients in Guangzhou, China: Prevalence, risk factors, phenotypic and molecular characteristics. J Infect Chemother. 2020 Oct 07;: Authors: He S, Lin J, Li L, Cai W, Ye J, Li Y, Zhang W, Liu N, Gong Z, Ye X, Yao Z Abstract INTRODUCTION: Data on comprehensive characterization of multidrug-resistant (MDR) Staphylococcus aureus (S. aureus) carriage in human immunodeficiency...
Mon Oct 12, 2020 14:09
Endovascular Treatment for Cerebral Venous Thrombosis. World Neurosurg. 2020 Sep 28;144:194-195 Authors: Coutinho JM, Ferro JM, Stam J PMID: 33039694 [PubMed - as supplied by publisher]
Mon Oct 12, 2020 14:06
Super-pedicle osteotomy for correction of focal thoracolumbar kyphosis. World Neurosurg. 2020 Oct 08;: Authors: Mejia-Munne JC, Robinson MW, Magner ME, Tabbosha M PMID: 33039570 [PubMed - as supplied by publisher]
Mon Oct 12, 2020 14:06
CT Image Analysis and Clinical Diagnosis Value of Nasal Olfactory Neuroblastoma. World Neurosurg. 2020 Oct 08;: Authors: Zhang S, Li Q, Zhang F, Xu H, Gao H Abstract This article retrospectively analysed the data of all patients diagnosed as malignant tumours of the nasal cavity and sinuses by pathological section in all patients (including outpatients and inpatients) in our hospital from January 2008 to December 2017 (10 years) to discuss...
Mon Oct 12, 2020 14:06
New insights into affinity proteins for HER2-targeted therapy: Beyond trastuzumab. Biochim Biophys Acta Rev Cancer. 2020 Oct 08;:188448 Authors: Akbari V, Chou CP, Abedi D Abstract Human epidermal growth factor receptor 2 (HER2) is known as a potential target for both cancer treatment and diagnosis. One of the most interesting HER2-targeted therapeutics is an affinity protein which selectively recognizes and binds to a defined target. Trastuzumab...
Mon Oct 12, 2020 14:03
An intronic variant in BRAT1 creates a cryptic splice site, causing epileptic encephalopathy without prominent rigidity. Acta Neurol Belg. 2020 Oct 10;: Authors: Colak FK, Guleray N, Azapagasi E, Yazıcı MU, Aksoy E, Ceylan N Abstract BRAT1-related neurodevelopmental disorders are characterized by heterogeneous phenotypes with varying levels of clinical severity. Since the discovery of BRAT1 variants as the molecular etiology of lethal neonatal...
Mon Oct 12, 2020 14:00
Effectiveness of Lacosamide on everyday cognitive deficits, psychiatric symptoms and resilience in patients with epilepsy. J Pak Med Assoc. 2020 Sep;70(9):1611-1615 Authors: Gul A, Mehreen S Abstract Lacosamide is a novel antiepileptic with neuroprotective properties. The present study examined the effectiveness of Lacosamide on cognitive functioning, psychiatric symptoms, and resilience in patients of refractory partial epilepsy. This prospective...
Mon Oct 12, 2020 14:00
Efficacy of low carbohydrate ketogenic diet in the treatment of Type 2 Diabetes. Med Princ Pract. 2020 Oct 09;: Authors: Dashti HM, Mathew TC, Al-Zaid NS Abstract Low carbohydrate ketogenic diet (LCKD), originally used as a treatment for childhood epilepsy is currently gaining acceptance as a nutritional therapy for obesity and type 2 diabetes. In addition, this diet has a positive effect on body weight, blood glucose level, glycosylated hemoglobin,...
Mon Oct 12, 2020 14:00
MRI-negative PET-negative epilepsy long-term surgical outcomes: A single-institution retrospective review. Epilepsy Res. 2020 Sep 30;167:106481 Authors: Pellinen J, Kuzniecky R, Doyle W, Devinsky O, Dugan P Abstract PURPOSE: Surgical planning for people with drug resistant non-lesional focal epilepsy can be challenging. Prior studies focus on cases that are only MRI-negative or MRI-negative with PET-positive imaging, but little is known about...
Mon Oct 12, 2020 14:00
Factors Affecting Women Surgeons' Careers in Low-Middle-Income Countries: An International Survey. World J Surg. 2020 Oct 10;: Authors: Malik M, Inam H, Janjua MBN, Martins RS, Zahid N, Khan S, Sattar AK, Haider AH, Enam SA Abstract BACKGROUND: Despite increasing numbers of women surgeons globally, barriers to career advancement persist. While these barriers have been extensively discussed in high-income countries (HICs), the topic has received...
Mon Oct 12, 2020 13:56
The Diagnostic Utility of Splenectomy in Idiopathic Splenomegaly. World J Surg. 2020 Oct 10;: Authors: Palumbo V, Vitale M, Toro A, Di Carlo I PMID: 33040192 [PubMed - as supplied by publisher]
Mon Oct 12, 2020 13:56
Effectiveness of expiratory flow acceleration in patients with Parkinson's disease and swallowing deficiency: A preliminary study. Clin Neurol Neurosurg. 2020 Sep 28;199:106249 Authors: Riboldazzi G, Spinazza G, Beccarelli L, Prato P, Grecchi B, D'Abrosca F, Nicolini A Abstract OBJECTIVES: Parkinson's disease (PD) causes dysfunction both to swallowing and to the cough mechanism. Oropharyngeal dysphagia is the main cause of pneumonia, due to...
Mon Oct 12, 2020 13:39
Tornwaldt nasopharyngeal cyst: Case series and literature review. Int J Surg Case Rep. 2020 Sep 21;76:166-169 Authors: Alshuhayb Z, Alkhamis H, Aldossary M, Almoumen Z, Aldhurais A, Alshuhayb B, Almomen A Abstract BACKGROUND: Tornwaldt cyst (TC) is a relatively rare but benign disease. Although these lesions are asymptomatic and found incidentally during routine ENT examination, the can present with unexplained sinonasal symptoms, such as nasal...
Mon Oct 12, 2020 13:37
The correlation between drug-induced sleep endoscopy findings and severity of obstructive sleep apnea. Auris Nasus Larynx. 2020 Oct 07;: Authors: Hsu YB, Lan MY, Huang YC, Huang TT, Lan MC Abstract OBJECTIVE: This study aimed to assess the relationship between anthropometric data, drug-induced sleep endoscopy (DISE) findings, and severity of obstructive sleep apnea (OSA). METHODS: From August 2016 to August 2017, a total of 147 surgically...
Mon Oct 12, 2020 13:32
Sleep apnea in rugby league. J Sci Med Sport. 2020 Nov;23(11):1005 Authors: Waddington GS PMID: 33038975 [PubMed - as supplied by publisher]
Mon Oct 12, 2020 13:32
Usefulness and practical insights of the pediatric video head impulse test. Int J Pediatr Otorhinolaryngol. 2020 Oct 05;139:110424 Authors: Kim KS, Jung YK, Hyun KJ, Kim MJ, Kim HJ Abstract OBJECTIVE: The video head impulse test (vHIT) is a diagnostic tool to examine patients experiencing dizziness by assessing the function of the semicircular canals. vHIT has been widely studied in adults but relatively less so in children. The aim of this...
Mon Oct 12, 2020 13:30
Systematic review of rigid and flexible esophagoscopy for pediatric esophageal foreign bodies. Int J Pediatr Otorhinolaryngol. 2020 Sep 25;139:110397 Authors: Yang W, Milad D, Wolter NE, Propst EJ, Chan Y Abstract BACKGROUND: Esophageal foreign body (EFB) is a common presentation in pediatric hospitals. Rigid and flexible esophagoscopy are both primary modalities used for EFB removal. By systematically reviewing the literature, we sought to...
Mon Oct 12, 2020 13:30
Nasal function and cardio-respiratory capacity of adolescent with external nasal dilator. Int J Pediatr Otorhinolaryngol. 2020 Oct 07;139:110430 Authors: Santos Ferreira CH, Dinardi RR, da Cunha Ibiapina C, Ribeiro de Andrade C Abstract BACKGROUND: the external nasal dilator (END) has been employed for the purpose of aiding sporting performance. The objective of this study was to evaluate nasal function and cardio-respiratory capacity in healthy...
Mon Oct 12, 2020 13:30
Five Specific Tongue Movements in a Healthy Population. Dysphagia. 2020 Oct 11;: Authors: Kappert KDR, van Dijk S, Wellenstein D, van Alphen MJA, van Son RJJH, Smeele LE, Balm AJM Abstract The importance of tongue mobility on speech, oral food transport, and swallowing is well recognized. However, whether the individual tongue mobility influences postoperative function in oral cancer treatment remains to be elucidated. This study assesses...
Mon Oct 12, 2020 13:30
Anticancer drug synergy prediction in understudied tissues using transfer learning. J Am Med Inform Assoc. 2020 Oct 11;: Authors: Kim Y, Zheng S, Tang J, Jim Zheng W, Li Z, Jiang X Abstract OBJECTIVE: Drug combination screening has advantages in identifying cancer treatment options with higher efficacy without degradation in terms of safety. A key challenge is that the accumulated number of observations in in-vitro drug responses varies...
Mon Oct 12, 2020 13:30
Outcomes Following Extracorporeal Photopheresis for Chronic Lung Allograft Dysfunction Following Lung Transplantation: A Single-Center Experience. Transplant Proc. 2020 Oct 07;: Authors: Vazirani J, Routledge D, Snell GI, Watson D, Paraskeva M, Westall GP, Harrison SJ Abstract INTRODUCTION: Survival following lung transplantation (LTx) is limited by the development of chronic lung allograft dysfunction (CLAD), for which there are few effective...
Mon Oct 12, 2020 13:30
The lessons to learn with regards to hospital admissions during the COVID-19 pandemic, a Commentary on "acute care surgery during the COVID-19 pandemic in Spain: Changes in volume, causes and complications. A multicentre retrospective cohort study". Int J Surg. 2020 Oct 08;: Authors: Dungar KD, Sooriah KL PMID: 33039654 [PubMed - as supplied by publisher]
Mon Oct 12, 2020 13:29
A Commentary on "Optimal management of large proximal ureteral stones (>10mm): a systematic review and meta-analysis of 12 randomized controlled trials" (International Journal of Surgery. 2020 July, https://doi.org/10.1016/j.ijsu.2020.06.025). Int J Surg. 2020 Oct 08;: Authors: Raheem AA, Alowidah I PMID: 33039653 [PubMed - as supplied by publisher]
Mon Oct 12, 2020 13:29
Delays in surgery for cholesteatoma due to COVID-19: is there an impact on rates of recidivism and major complications? Eur Arch Otorhinolaryngol. 2020 Oct 10;: Authors: Hussain MH, Mair M, Mahmood S, Sakagiannis G, Rojoa DM, Raheman FJ, Irvine E, Rea P Abstract PURPOSE: To evaluate the relationship between the waiting time for surgery, and cholesteatoma recidivism rates and major complications. The secondary aims were to identify any other...
Mon Oct 12, 2020 13:24
Objective: To investigate the minimum bone thickness in adults and children in the area of the skull affected by implantation of a new bone conduction device in patients without known medical history that indicates anatomical malformations. Study Design: Retrospective, non-interventional study on computer tomography (CT) scans on file at a university medical center. Study Methods: A digital model of the new bone conduction implant was virtually implanted in 3D reconstructions...
Fri Oct 09, 2020 03:00
Hypothesis: Intracochlear pressure measurements in one cochlear scala are sufficient as reference to determine the output of an active middle ear implant (AMEI) in terms of “equivalent sound pressure level” (eqSPL). Background: The performance of AMEIs is commonly calculated from stapes velocities or intracochlear pressure differences (PDiff). However, there are scenarios where measuring stapes velocities or PDiff may not be feasible, for example when access to the stapes or one of...
Fri Oct 09, 2020 03:00
Purpose: This study is directed towards establishing a correlation between the objective measurement of tympanic membrane (TM) perforation size with hearing loss in patients with inactive mucosal chronic otitis media (COM), and to compare the otoscopic findings of the TM perforation vis-a-vis the results obtained by image analysis of the endoscopic image of the perforation. Materials and methods: An observational, prospective and hospital based study was performed on 107 ears (78 patients)...
Fri Oct 09, 2020 03:00
Objective: To evaluate adverse events and feasibility of performing 1.5-T MRI in patients with cochlear implants (CI) and auditory brainstem implants (ABI). Setting: Single tertiary academic referral center. Patients: CI and ABI recipients undergoing 1.5-T MRI without internal magnet removal. Intervention(s): MRI after tight headwrap application. Main Outcome Measures: Adverse events, patient tolerance. Results: A total of 131 MR studies in 79 patients...
Fri Oct 09, 2020 03:00
Objective: Report the details of an unusual case of initially unilateral intradural spontaneous otogenic pneumocephalus in which the patient developed contralateral pneumocephalus after surgical repair of temporal bone and dural defects on the initial side. Discuss the lessons learned concerning management and pathophysiology of this rare case. Patient: A 73-year-old male presenting with bilateral retro-orbital pain and headache was found to have unilateral intradural pneumocephalus...
Fri Oct 09, 2020 03:00
Abstract The year 2021 marks the 20th anniversary of the first publications reporting the discovery of the gene silencing mechanism, RNA interference (RNAi) in mammalian cells. Along with the many studies that delineated the proteins and substrates that form the RNAi pathway, this finding changed our understanding of the posttranscriptional regulation of mammalian gene expression. Furthermore, the development of methods that exploited the RNAi pathway began the technological revolution that eventually...
Mon Oct 12, 2020 13:11
Abstract Objectives Longitudinal evaluation of Oral Health‐Related Quality of Life (OHRQoL) during treatment of flaplessly placed, one‐piece mini‐dental‐implants (MDIs) for maxillary overdentures is rarely investigated, nor is the impact of MDI failures. Material & Methods This multicenter prospective cohort study evaluated the 3‐year outcome of 5‐6 MDIs in the edentulous maxilla in patients above 50 years with dentate mandible. Provisional dentures were provided before final prosthetic...
Mon Oct 12, 2020 11:15
Mon Oct 05, 2020 11:17
Mon Oct 05, 2020 11:17
Langerhans cell histiocytosis mimicking prurigo nodularis. J Eur Acad Dermatol Venereol. 2020 Oct 11;: Authors: Traidl S, Angela Y, Wedi B, Kapp A, Werfel T, Schacht V Abstract Langerhans cell histiocytosis (LCH) depicts a rare disease belonging to the group of histiocytoses. The disease is based on a clonal expansion of myeloid precursors. Frequently, gain-of-function mutation in the MAPK signaling pathway can be detected.1,2 In 2016, Emile...
Mon Oct 12, 2020 13:09
Prognostic value of PSMA, c-MET and E-cadherin in salivary duct carcinoma. Oral Oncol. 2020 Oct 08;110:105018 Authors: van Boxtel W, Uijen MJM, Verhaegh GW, Willems SM, Jonker MA, PALGA Group, Schalken JA, van Engen-van Grunsven ICH, van Herpen CML Abstract OBJECTIVES: Salivary duct carcinoma (SDC) is a rare and aggressive subtype of salivary gland cancer. Androgen receptor (AR) (96%) and HER2 (29-46%) expression, and a high propensity for...
Mon Oct 12, 2020 13:09
The radiotherapy utilization rate in pediatric tumors: an analysis of 13,305 patients. Radiother Oncol. 2020 Oct 08;: Authors: Bishr MK, Zaghloul MS, Elmaraghi C, Galalc Mohamed S Abdelaziz A, Elghazawy HI, Shaheen H, Ramzy ES, Mesbah A, Eissa SK, Hegazy R, Hamza AM, Elkhateeb N, Mousa AG Abstract PURPOSE: Although the radiotherapy utilization rate (RUR) is determined for most adult cancers, it is seldom reported in childhood tumors, particularly...
Mon Oct 12, 2020 13:09
Adenoid Cystic Carcinoma of the Breast detected with Contrast-Enhanced Spectral Mammography: A Case Report. Curr Med Imaging. 2020 Oct 09;: Authors: Cheung YC, Ueng SH, Ng SH, Kuo WL Abstract BACKGROUND: Contrast-enhanced spectral mammogram (CESM) is a modern technique providing additional information to detect or diagnose the breast cancers. INTRODUCTION: We present a rare ACC of breast on CESM. METHODS: A 49-year-old woman...
Mon Oct 12, 2020 13:09
Solitary chemosensory cells are innervated by trigeminal nerve endings and autoregulated by cholinergic receptors. Int Forum Allergy Rhinol. 2020 Oct 11;: Authors: Deng J, Tan LH, Kohanski MA, Kennedy DW, Bosso JV, Adappa ND, Palmer JN, Shi J, Cohen NA Abstract BACKGROUND: Solitary chemosensory cells (SCCs) in the murine nasal epithelium are discrete specialized cells that respond to irritants and activate trigeminal nerve fibers through...
Mon Oct 12, 2020 13:04
Validation of brief symptom indexes among patients with recurrent or metastatic squamous cell carcinoma of the head and neck: A trial of the ECOG-ACRIN Cancer Research Group (E1302). Cancer Med. 2020 Oct 10;: Authors: Oswald LB, Lee JW, Argiris A, Webster KA, Forastiere AA, Cella D Abstract BACKGROUND: Patients with advanced head and neck cancer have identified pain, fatigue, and difficulties swallowing, breathing, and communicating as...
Mon Oct 12, 2020 13:04
Microcrack surface density in the human otic capsule: an unbiased stereological quantification. Anat Rec (Hoboken). 2020 Oct 11;: Authors: Hansen LJ, Bloch SL, Frisch T, Sørensen MS Abstract Bone is continuously remodeled to repair and strengthen degenerative bone with accumulating dead osteocytes and microfractures. Inner ear osteoprotegerin (OPG)-mediated inhibition of otic capsular bone remodeling causes excessive perilabyrinthine bone...
Mon Oct 12, 2020 13:04
Amelanotic melanoma of the head and neck: analysis of tumor characteristics from the National Cancer Database. Int J Dermatol. 2020 Oct 11;: Authors: Huayllani MT, Boczar D, Saleem HY, Spaulding AC, Bagaria SP, Lu X, Kassis S, Perdikis G, Forte AJ Abstract BACKGROUND: Amelanotic melanoma is an extremely rare subtype of cutaneous melanoma. The tumor characteristics are still not well understood, especially for those located in the head...
Mon Oct 12, 2020 13:04
Tinnitus Questionnaires for Research and Clinical Use. Curr Top Behav Neurosci. 2020 Oct 11;: Authors: Theodoroff SM Abstract The lack of an objective measure of tinnitus has led to self-report questionnaires as the best option to evaluate tinnitus symptoms and quantify the degree to which quality of life is negatively impacted. There are many tinnitus questionnaires to choose from and it can be difficult to decide which one is best. From...
Mon Oct 12, 2020 13:04
Five Specific Tongue Movements in a Healthy Population. Dysphagia. 2020 Oct 11;: Authors: Kappert KDR, van Dijk S, Wellenstein D, van Alphen MJA, van Son RJJH, Smeele LE, Balm AJM Abstract The importance of tongue mobility on speech, oral food transport, and swallowing is well recognized. However, whether the individual tongue mobility influences postoperative function in oral cancer treatment remains to be elucidated. This study assesses...
Mon Oct 12, 2020 13:04
Sclerosing variant of mucoepidermoid carcinoma: a diagnostic challenge. BMJ Case Rep. 2020 Oct 10;13(10): Authors: Rasul U, Bradish T, Bashir MT, Shakeel M Abstract The sclerosing variant of mucoepidermoid salivary gland carcinoma is extremely rare. It is nearly impossible to diagnose this condition preoperatively. We present a case of a 23-year-old woman with a 1-year history of left parotid enlargement with inconclusive fine-needle aspiration...
Mon Oct 12, 2020 13:04
Violence against doctors: an emerging epidemic amidst COVID-19 pandemic in India. Postgrad Med J. 2020 Oct 10;: Authors: Sakthivel P, Rajeshwari M, Malhotra N, Ish P PMID: 33040027 [PubMed - as supplied by publisher]
Mon Oct 12, 2020 13:04
Does laser photobiomodulation prevent hyposalivation in patients undergoing head and neck radiotherapy? A systematic review and meta-analysis of controlled trials. Crit Rev Oncol Hematol. 2020 Oct 01;156:103115 Authors: Louzeiro GC, Teixeira DDS, Cherubini K, de Figueiredo MAZ, Salum FG Abstract INTRODUCTION: Head and neck radiotherapy can cause hypofunction of the salivary glands. Many studies report that laser photobiomodulation (PBM)...
Mon Oct 12, 2020 13:04
Usefulness and practical insights of the pediatric video head impulse test. Int J Pediatr Otorhinolaryngol. 2020 Oct 05;139:110424 Authors: Kim KS, Jung YK, Hyun KJ, Kim MJ, Kim HJ Abstract OBJECTIVE: The video head impulse test (vHIT) is a diagnostic tool to examine patients experiencing dizziness by assessing the function of the semicircular canals. vHIT has been widely studied in adults but relatively less so in children. The aim of...
Mon Oct 12, 2020 13:04
A Rare Cause of a Liver Tumor Nodule. Gastroenterology. 2020 Oct 08;: Authors: Chau IY, Chen YY, Chau GY PMID: 33039472 [PubMed - as supplied by publisher]
Mon Oct 12, 2020 13:04
Severe olfactory and gustatory dysfunctions in a Japanese pediatric patient with coronavirus disease (COVID-19). J Infect Chemother. 2020 Sep 30;: Authors: Kasuga Y, Nishimura K, Go H, Nakazaki K, Shimizu S, Kanezawa K, Tanaka M, Oshima T, Morioka I Abstract Coronavirus disease (COVID-19) is often characterized by abnormal olfactory and gustatory symptoms in adults; however, detailed studies on pediatric patients with COVID-19 are extremely...
Mon Oct 12, 2020 13:04
Optimal current intensity for supramaximal stimulation during electroneurography for facial palsy. Auris Nasus Larynx. 2020 Oct 07;: Authors: Ayani Y, Haginomori SI, Wada SI, Nakano H, Inaka Y, Ozaki A, Ichihara T, Inui T, Kawata R Abstract OBJECTIVE: To determine the optimal current intensity for supramaximal stimulation during electroneurography (ENoG) for facial palsy. METHODS: Forty patients with unilateral facial palsy (32...
Mon Oct 12, 2020 13:04
Coronavirus Disease 2019: Challenges Associated with the Treatment of Head and Neck Oncology and Laryngology Patients in the Coronavirus Disease 2019 Era. Otolaryngol Clin North Am. 2020 Aug 22;: Authors: Baird BJ, Sung CK Abstract This review explores the changes to practice associated with COVID-19 for providers treating patients with head and neck cancer and laryngeal pathology. The aim of the review is to highlight some of the challenges...
Mon Oct 12, 2020 13:04
Otolaryngology During the COVID-19 Pandemic: What We Have Learned in Year One. Otolaryngol Clin North Am. 2020 Sep 15;: Authors: Chandrasekhar SS PMID: 33039098 [PubMed - as supplied by publisher]
Mon Oct 12, 2020 13:04
Coronavirus Disease-19 and Rhinology/Facial Plastics. Otolaryngol Clin North Am. 2020 Aug 19;: Authors: Davis ME, Yan CH Abstract This review summarizes the challenges and adaptations that have taken place in rhinology and facial plastics in response to the ongoing coronavirus disease-19 pandemic. In particular, the prolonged exposure and manipulation of the nasal and oral cavities portend a high risk of viral transmission. We discuss...
Mon Oct 12, 2020 13:04
Robotics in Otolaryngology. Otolaryngol Clin North Am. 2020 Oct 07;: Authors: Thaler ER, Sharma A, Duvvuri U PMID: 33039096 [PubMed - as supplied by publisher]
Mon Oct 12, 2020 13:04
Machine Intelligence in Neurologic and Head and Neck Imaging. Neuroimaging Clin N Am. 2020 Nov;30(4):xvii-xviii Authors: Forghani R PMID: 33039005 [PubMed - as supplied by publisher]
Mon Oct 12, 2020 13:04
Foreword. Neuroimaging Clin N Am. 2020 Nov;30(4):xv Authors: Mukherji SK PMID: 33039004 [PubMed - as supplied by publisher]
Mon Oct 12, 2020 13:04
Overview of Machine Learning Part 1: Fundamentals and Classic Approaches. Neuroimaging Clin N Am. 2020 Nov;30(4):e17-e32 Authors: Maleki F, Ovens K, Najafian K, Forghani B, Reinhold C, Forghani R Abstract The extensive body of research and advances in machine learning (ML) and the availability of a large volume of patient data make ML a powerful tool for producing models with the potential for widespread deployment in clinical settings....
Mon Oct 12, 2020 13:04
Artificial Intelligence Applications for Workflow, Process Optimization and Predictive Analytics. Neuroimaging Clin N Am. 2020 Nov;30(4):e1-e15 Authors: Letourneau-Guillon L, Camirand D, Guilbert F, Forghani R Abstract There is great potential for artificial intelligence (AI) applications, especially machine learning and natural language processing, in medical imaging. Much attention has been garnered by the image analysis tasks for diagnostic...
Mon Oct 12, 2020 13:04
Machine Learning Applications for Head and Neck Imaging. Neuroimaging Clin N Am. 2020 Nov;30(4):517-529 Authors: Maleki F, Le WT, Sananmuang T, Kadoury S, Forghani R Abstract The head and neck (HN) consists of a large number of vital anatomic structures within a compact area. Imaging plays a central role in the diagnosis and management of major disorders affecting the HN. This article reviews the recent applications of machine learning...
Mon Oct 12, 2020 13:04
Machine Learning Algorithm Validation: From Essentials to Advanced Applications and Implications for Regulatory Certification and Deployment. Neuroimaging Clin N Am. 2020 Nov;30(4):433-445 Authors: Maleki F, Muthukrishnan N, Ovens K, Reinhold C, Forghani R Abstract The deployment of machine learning (ML) models in the health care domain can increase the speed and accuracy of diagnosis and improve treatment planning and patient care. Translating...
Mon Oct 12, 2020 13:04
Overview of Machine Learning: Part 2: Deep Learning for Medical Image Analysis. Neuroimaging Clin N Am. 2020 Nov;30(4):417-431 Authors: Le WT, Maleki F, Romero FP, Forghani R, Kadoury S Abstract Deep learning has contributed to solving complex problems in science and engineering. This article provides the fundamental background required to understand and develop deep learning models for medical imaging applications. The authors review...
Mon Oct 12, 2020 13:04
Knowledge Based Versus Data Based: A Historical Perspective on a Continuum of Methodologies for Medical Image Analysis. Neuroimaging Clin N Am. 2020 Nov;30(4):401-415 Authors: Savadjiev P, Reinhold C, Martin D, Forghani R Abstract The advent of big data and deep learning algorithms has promoted a major shift toward data-driven methods in medical image analysis recently. However, the medical image analysis field has a long and rich history...
Mon Oct 12, 2020 13:04
Brief History of Artificial Intelligence. Neuroimaging Clin N Am. 2020 Nov;30(4):393-399 Authors: Muthukrishnan N, Maleki F, Ovens K, Reinhold C, Forghani B, Forghani R Abstract This article reviews the history of artificial intelligence and introduces the reader to major events that prompted interest in the field, as well as pitfalls and challenges that have slowed its development. The purpose of this article is to provide a high-level...
Mon Oct 12, 2020 13:04
Re-expression of DIRAS3 and p53 induces apoptosis and impaired autophagy in head and neck squamous cell carcinoma. Mil Med Res. 2020 Oct 11;7(1):48 Authors: Liu Z, Hurst DR, Qu X, Lu LG, Wu CZ, Li YY, Li Y Abstract BACKGROUND: p53 and DIRAS3 are tumor suppressors that are frequently silenced in tumors. In this study, we sought to determine whether the concurrent re-expression of p53 and DIRAS3 could effectively induce head and neck squamous...
Mon Oct 12, 2020 13:04
EBP2, a novel NPM-ALK-interacting protein in the nucleolus, contributes to the proliferation of ALCL cells by regulating tumor suppressor p53. Mol Oncol. 2020 Oct 10;: Authors: Uchihara Y, Tago K, Tamura H, Funakoshi-Tago M Abstract The oncogenic fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), found in anaplastic large cell lymphoma (ALCL), localizes to the cytosol, nucleoplasm, and nucleolus. However, the relationship...
Mon Oct 12, 2020 13:04
ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner. Ecotoxicol Environ Saf. 2020 Oct 08;208:111436 Authors: Zhang ZH, Hong Q, Zhang ZC, Xing WY, Xu S, Tian QX, Ye QL, Wang H, Yu DX, Xie DD, Xu DX Abstract Several epidemiological studies reported that chronic arsenic exposure increased risk of prostate cancer. This study...
Mon Oct 12, 2020 13:04
Targeted inhibition of c-MET by podophyllotoxin promotes caspase-dependent apoptosis and suppresses cell growth in gefitinib-resistant non-small cell lung cancer cells. Phytomedicine. 2020 Sep 25;80:153355 Authors: Oh HN, Kwak AW, Lee MH, Kim E, Yoon G, Cho SS, Liu K, Chae JI, Shim JH Abstract BACKGROUND: Lung cancer has the highest incidence and cancer-related mortality of all cancers worldwide. Its treatment is focused on molecular targeted...
Mon Oct 12, 2020 13:04
Dracocephalum palmatum Stephan extract induces apoptosis in human prostate cancer cells via the caspase-8-mediated extrinsic pathway. Chin J Nat Med. 2020 Oct;18(10):793-800 Authors: Lee SE, Okhlopkova Z, Lim C, Cho S Abstract Dracocephalum palmatum Stephan is a medicinal plant traditionally used by nomadic people in Eastern Russia; however, research on this plant is currently limited. Recently, although studies have been conducted on...
Mon Oct 12, 2020 13:04
Effect of Sargassum fusiforme polysaccharide on apoptosis and its possible mechanism in human erythroleukemia cells. Chin J Nat Med. 2020 Oct;18(10):749-759 Authors: Ding HM, Chen XJ, Chen HM, Wang CS, Qian GY Abstract This study aimed to investigate the effects of Sargassum fusiforme polysaccharide (SFPS I, II, and III) on the apoptosis and regulation of human erythroleukemia (HEL) cells. The effect of different doses of SFPS on HEL cell...
Mon Oct 12, 2020 13:04
Re-expression of DIRAS3 and p53 induces apoptosis and impaired autophagy in head and neck squamous cell carcinoma. Mil Med Res. 2020 Oct 11;7(1):48 Authors: Liu Z, Hurst DR, Qu X, Lu LG, Wu CZ, Li YY, Li Y Abstract BACKGROUND: p53 and DIRAS3 are tumor suppressors that are frequently silenced in tumors. In this study, we sought to determine whether the concurrent re-expression of p53 and DIRAS3 could effectively induce head and neck squamous...
Mon Oct 12, 2020 13:04
Neuroblastoma is a common malignancy and frequently affects children, leading to a low survival rate. Long noncoding RNAs (lncRNAs) are reported to be closely related to cancer progression. The purpose of this study was to explore a novel mechanism of lncRNA nuclear-enriched abundant transcript 1 (NEAT1) in neuroblastoma. NEAT1 was upregulated in neuroblastoma cell lines (IMR32 and SK-N-SH). Overexpression of NEAT1 increased proliferation inhibited by cisplatin and decreased apoptosis promoted by...
Thu Oct 08, 2020 03:00
This study investigated the relationship between perceptual priming and subsequent recognition memory using conceptually impoverished kaleidoscope images as stimuli. Event-related potentials (ERPs) were recorded to explore the ERPs related to perceptual priming and their relationship with subsequent recognition memory. The results revealed that the early ERP perceptual priming effect between 100 and 300 ms, which might reflect perceptual fluency, was significant for both subsequent remembered and...
Thu Oct 08, 2020 03:00
The proliferation and migration of Schwann cells contribute to axonal outgrowth and functional recovery after peripheral nerve injury. Previously, several microRNAs were abnormally expressed after peripheral nerve injury and they played important roles in peripheral nerve regeneration. However, the role and underlying mechanism of miR-34a in peripheral nerve injury remain largely unknown. The levels of miR-34a and contactin-2 (CNTN2) were detected by quantitative real-time PCR. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium...
Thu Oct 08, 2020 03:00
Recent structural MRI studies on gray matter (GM) volumes using group-level mass-univariate statistical analysis suggest that chronic and heavy cannabis exposure may affect brain region-based morphology. In this prospective study, we use a multivariate pattern analysis approach to investigate the voxel-level change of GM densities in chronic heavy cannabis users. Principal component analysis and linear support vector machine are used in this study, resulting in an 88.1% separation between chronic...
Thu Oct 08, 2020 03:00
COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused significant morbidity and mortality. COVID-19 often presents with respiratory symptoms; however, the role of asthma in COVID-19 has not been well established. While studies from China suggested that asthma was not a risk factor for severe COVID-19, other studies have shown higher rates of asthma among hospitalized patients1,2. Therefore, the primary aim of this study was to assess the associations between asthma...
Mon Oct 12, 2020 03:00
Abstract Auditory statistical learning (ASL) plays a role in language development and may lay a foundation for later social communication impairment. As part of a longitudinal study of infant siblings, we asked whether electroencephalography (EEG) measures of connectivity during ASL at 3 months of age differentiated infants who showed signs of autism spectrum disorder (ASD) at age 18 months. We measured spectral power and phase coherence in the theta (4–6 Hz) and alpha (6–12 Hz) frequency bands...
Mon Oct 12, 2020 11:17
The relationship between radiotherapy (RT) and heart disease has been reported mostly in patients receiving RT for breast cancer or Hodgkin lymphoma in their long-term disease course [1,2]. Since Darby et al. [3] addressed the risk of ischemic heart disease after RT in patients with breast cancer, much attention has been paid to RT-related cardiac toxicity. Still, the long-term effects of RT on cardiovascular (CV) disease have been underestimated in patients with locally advanced lung cancer due...
Mon Oct 12, 2020 03:00
Abstract Background The aim of the study was to describe a novel technique for reinforcement of salvage laryngectomy closure using a bipedicled musculofascial submental flap. Methods A retrospective cohort study design identified patients who underwent salvage laryngectomy reinforcement with a bipedicled submental hammock flap between January 2008 and December 2016 were compared to salvage laryngectomy patients treated with primary closure of the neopharynx during the same time period....
Mon Oct 12, 2020 11:25
Perforator‐based propeller flaps for reconstruction of massive anterolateral thigh donor site wounds
Abstract Background Wide anterolateral thigh (ALT) flap donor site defects may make primary closure difficult or impossible, with split thickness skin grafting and/or negative pressure therapy often used instead. Here, we describe a technique using propeller flaps based on varying thigh perforating vasculature in donor site reconstruction for these larger deformities. Methods Case series Results Three patients are described that had perforator‐based propeller flap reconstruction of...
Mon Oct 12, 2020 11:24
Abstract Background In patients presenting with recurrent pleomorphic adenoma (rPA), clinical evaluation can fail to recognize carcinoma ex PA (cxPA). We aim to identify the risk factors for cxPA. Methods This is a single institution retrospective case‐control study from 2000 to 2015. CxPA was diagnosed based on surgical pathology. Demographics, clinical, and social histories were collected. Results A number of 13/106 (12.3%) patients were diagnosed with cxPA, of which only 4/13 (31%)...
Mon Oct 12, 2020 11:24
Abstract Background To conduct a meta‐analysis to compare the safety and efficacy of transoral endoscopic thyroidectomy vestibular approach (TOETVA) with conventional open thyroidectomy (COT). Methods MEDLINE, EMBASE, Science Citation Index Expanded, and the Cochrane Central Register of Controlled Trials in the Cochrane Library from January 2007 to March 2020 were searched to identify studies comparing TOETVA and COT. Results Six eligible nonrandomized studies involving 1151 patients...
Mon Oct 12, 2020 11:23
Summary Background Epinephrine is the first‐line treatment for anaphylaxis. Patients at risk should always carry an epinephrine auto‐injector (EAI). Several EAI gaps have been identified. We sought to evaluate satisfaction using a medical device (digital technology comprising an EAI smart case connected to a mobile APP) with functions that overcome most of the EAI limitations and to determine whether patient behaviour and anaphylaxis management improve with its use. Methods This was a randomised,...
Mon Oct 12, 2020 12:00
Abstract Background Food allergy (FA) is a growing health problem worldwide. Effective strategies are advocated to limit the disease burden. Human milk (HM) is considered a protective factor for FA, but its mechanisms remain unclear. Butyrate is a gut microbiota‐derived metabolite able to exert several immunomodulatory functions. Objectives To define the butyrate concentration in HM. To see whether the butyrate concentration detected in HM is able to modulate the mechanisms of immune tolerance....
Sun Oct 11, 2020 20:19
Abstract Most colorectal cancers (CRCs) are differentiated adenocarcinomas, which maintain expression of both stemness and differentiation markers. This observation suggests that CRC cells could retain a regeneration system of normal cells upon injury. However, the role of stemness in cancer cell regeneration after irradiation is poorly understood. Here, we examined the effect of radiation on growth, stemness, and differentiation in organoids derived from differentiated adenocarcinomas. Following...
Sun Oct 11, 2020 20:43
Background The importance of addressing adverse financial effects of cancer among adolescents and young adults (AYAs) is paramount as survival improves. In the current study, the authors examined whether cancer‐related employment disruption was associated with financial hardship among female AYA cancer survivors in North Carolina and California. Methods AYA cancer survivors identified through the North Carolina Central Cancer Registry and the Kaiser Permanente Northern/Southern California...
Mon Oct 12, 2020 10:56
The Editor has retracted this article [1] because there are concerns about the scientific validity of the study and undeclared conflicts of interest.
Mon Oct 12, 2020 03:00
Abstract The inflammatory response involving interleukin-1β (IL-1β) has been thought to play an important role in the development of late-phase sepsis. However, in this study, we wanted to explore the possibility of using IL-1β to improve the prognosis of sepsis by triggering local differentiation of bone marrow cells (BMCs) into regulatory dendritic cells (DCs) in vivo, thereby reversing the immune paralysis in late-phase sepsis. Sepsis mouse models were induced by cecal ligation...
Mon Oct 12, 2020 03:00
Objective: To investigate the minimum bone thickness in adults and children in the area of the skull affected by implantation of a new bone conduction device in patients without known medical history that indicates anatomical malformations. Study Design: Retrospective, non-interventional study on computer tomography (CT) scans on file at a university medical center. Study Methods: A digital model of the new bone conduction implant was virtually implanted in 3D reconstructions of temporal...
Fri Oct 09, 2020 03:00
Hypothesis: Intracochlear pressure measurements in one cochlear scala are sufficient as reference to determine the output of an active middle ear implant (AMEI) in terms of “equivalent sound pressure level” (eqSPL). Background: The performance of AMEIs is commonly calculated from stapes velocities or intracochlear pressure differences (PDiff). However, there are scenarios where measuring stapes velocities or PDiff may not be feasible, for example when access to the stapes or one of the scalae...
Fri Oct 09, 2020 03:00
Purpose: This study is directed towards establishing a correlation between the objective measurement of tympanic membrane (TM) perforation size with hearing loss in patients with inactive mucosal chronic otitis media (COM), and to compare the otoscopic findings of the TM perforation vis-a-vis the results obtained by image analysis of the endoscopic image of the perforation. Materials and methods: An observational, prospective and hospital based study was performed on 107 ears (78 patients)...
Fri Oct 09, 2020 03:00
Objective: To evaluate adverse events and feasibility of performing 1.5-T MRI in patients with cochlear implants (CI) and auditory brainstem implants (ABI). Setting: Single tertiary academic referral center. Patients: CI and ABI recipients undergoing 1.5-T MRI without internal magnet removal. Intervention(s): MRI after tight headwrap application. Main Outcome Measures: Adverse events, patient tolerance. Results: A total of 131 MR studies in 79 patients were performed,...
Fri Oct 09, 2020 03:00
Objective: Report the details of an unusual case of initially unilateral intradural spontaneous otogenic pneumocephalus in which the patient developed contralateral pneumocephalus after surgical repair of temporal bone and dural defects on the initial side. Discuss the lessons learned concerning management and pathophysiology of this rare case. Patient: A 73-year-old male presenting with bilateral retro-orbital pain and headache was found to have unilateral intradural pneumocephalus in the...
Fri Oct 09, 2020 03:00
No abstract available
Fri Oct 09, 2020 03:00
An insider's look at key highlights and challenges of ototoxicity research over the years and a discussion of exciting emerging studies to watch for, written in an engaging Q & A format with a distinguished audiology innovator.
Mon Oct 12, 2020 07:00
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