Evolutionary theory predicts that vertically transmitted symbionts are selected for low virulence, as their fitness is directly correlated to that of their host. In contrast with this prediction, the Wolbachia strain wMelPop drastically reduces its Drosophila melanogaster host lifespan at high rearing temperatures. It is generally assumed that this feature is maintained because the D. melanogaster-wMelPop symbiosis is usually not exposed to environmental conditions in which the symbiont is virulent....
Mon Oct 12, 2020 03:00
Biodiversity in southwestern North America has a complex biogeographic history involving tectonism interspersed with climatic fluctuations. This yields a contemporary pattern replete with historic idiosyncrasies often difficult to interpret when viewed from through the lens of modern ecology. The Aspidoscelis tigris (Tiger Whiptail) complex (Squamata: Teiidae) is one such group in which potential taxonomic boundaries have been confounded by a series of complex biogeographic processes that have defined...
Mon Oct 12, 2020 03:00
Symbiotic relationships between bioluminescent bacteria and fishes have evolved multiple times across hundreds of fish taxa, but relatively little is known about the specificity of these associations and how conserved they have been through time. This study describes the degree of specificity of a bioluminescent symbiosis between cardinalfishes in the genus Siphamia and luminous bacteria in the Vibrio family. Primarily using museum specimens, we investigate the co-divergence of host and symbiont...
Mon Oct 12, 2020 03:00
Human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is most closely related, by average genetic distance, to two coronaviruses isolated from bats, RaTG13 and RmYN02. However, there is a segment of high amino acid similarity between human SARS-CoV-2 and a pangolin isolated strain, GD410721, in the receptor binding domain (RBD) of the spike protein, a pattern that can be caused by either recombination or by convergent amino acid evolution driven by natural selection. We perform a detailed...
Mon Oct 12, 2020 03:00
Management of agricultural pests requires an understanding of pest species diversity, their interactions with beneficial insects and spatial-temporal patterns of pest abundance. Invasive and agriculturally important insect pests can build up very high populations, especially in cropping landscapes. Traditionally, sampling effort for species identification involves small sample sizes and is labour intensive. Here, we describe a high throughput sequencing (HTS) PCR amplicon method and associated analytical...
Mon Oct 12, 2020 03:00
Lake Malawi cichlid fishes exhibit extensive divergence in form and function among closely related species separated by a relatively small number of genetic changes. During the past million years, hundreds of species have diversified along an ecological axis in rock vs. sand habitats. We compared the genomes of rock- and sand-dwelling species and asked which genetic variants in which genes differed among the groups. We found that 96% of differentiated variants reside in non-coding sequence but these...
Mon Oct 12, 2020 03:00
The Himalayan uplift, a tectonic event of global importance, seemingly disseminated aquatic biodiversity broadly across Asia. But surprisingly, this hypothesis has yet to be tested. We do so herein by sequencing 1,140 base-pair of mtDNA cytochrome-b for 72 tetraploid Nepalese/Bhutanese Snowtrout (Schizothorax spp.), combining those data with 67 GENBANK sequences (59 ingroup/8 outgroup), then reconstructing phylogenetic relationships using maximum likelihood/ Bayesian analyses. Results indicate Snowtrout...
Mon Oct 12, 2020 03:00
Unsupervised AI (artificial intelligence) can obtain novel knowledge from big data without particular models or prior knowledge and is highly desirable for unveiling hidden features in big data. SARS-CoV-2 poses a serious threat to public health and one important issue in characterizing this fast-evolving virus is to elucidate various aspects of their genome sequence changes. We previously established unsupervised AI, a BLSOM (batch-learning SOM), which can analyze five million genomic sequences...
Mon Oct 12, 2020 03:00
Hosts with high immune sensitivity benefit from rapid recovery but suffer multiple costs thereof. We distinguish between immunopathological costs due to collateral damage and autoimmune costs due to false positives against self. Selection on sensitivity follows different trajectories depending on the cost nature and the overlap degree between host- and parasitic molecular signatures. Increased parasite virulence selects for higher immune sensitivity under immunopathological costs but low sensitivity...
Mon Oct 12, 2020 03:00
British Journal of Cancer, Published online: 13 October 2020; doi:10.1038/s41416-020-01076-0Survival of patients with deficient mismatch repair metastatic colorectal cancer in the pre-immunotherapy era
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British Journal of Cancer, Published online: 13 October 2020; doi:10.1038/s41416-020-01109-8Droplet-digital PCR reveals frequent mutations in TERT promoter region in breast fibroadenomas and phyllodes tumours, irrespective of the presence of MED12 mutations
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Abstract Purpose Radioimmunotherapy (RIT) delivered through the cerebrospinal fluid (CSF) has been shown to be a safe and promising treatment for leptomeningeal metastases. Pharmacokinetic models for intraOmmaya antiGD2 monoclonal antibody 131I-3F8 have been proposed to improve therapeutic effect while minimizing radiation toxicity. In this study, we now apply pharmacokinetic modeling to intraOmmaya 131I-omburtamab (8H9), an antiB7-H3...
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J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1715590 Objectives The present study examines the effect of median household income on mid- and long-term outcomes in a posterior fossa brain tumor resection population. Design This is a retrospective regression analysis. Setting The study conducted at a single, multihospital, urban academic medical center. Participants A total of 283 consecutive posterior fossa brain tumor cases, excluding cerebellar pontine...
Mon Oct 12, 2020 02:00
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1716692 Objective Carotid blowout syndrome (CBS) is a rare but potentially life-threatening complication of head and neck cancer (HNC) treatment. Patients with CBS are managed with covered stents, limited published information exists regarding the management of delayed complications, specifically cutaneous exposure of stents. Here, we present our experience managing cutaneously exposed carotid artery stents (CAS) in patients with recurrent...
Mon Oct 12, 2020 02:00
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1716676 Objectives The aim of the study is to evaluate the effect of preoperative vascular embolization (PVE) on juvenile nasopharyngeal angiofibroma (JNA) surgical outcomes using a national pediatric hospitalization database. Methods The health care cost and utilization project Kids' Inpatient Database was queried for all cases of operative management of JNA between the years of 1997 and 2016. Cases were stratified based on whether...
Mon Oct 12, 2020 02:00
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1716694 Objectives Targeted inhibitors of the PI3 kinase (PI3K) pathway have shown promising but incomplete antitumor activity in preclinical chordoma models. The aim of this study is to advance methodology for a high-throughput drug screen using chordoma models to identify new combination therapies for chordoma. Study Design Present work is an in vitro study. Setting The study conducted at an academic research laboratory....
Mon Oct 12, 2020 02:00
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1716890 Objective Many external anatomical landmarks have been used for approximating deeper, intracranial structures. Herein, we evaluate the attachment of the longissimus capitis (LC) on the mastoid process as a landmark for the underlying sigmoid sinus. Methods Adult cadavers underwent dissection of the posterior occiput with special attention to the attachment of the LC muscle. Once the periphery of the muscle's tendon of attachment...
Mon Oct 12, 2020 02:00
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1716674 Background To prevent damage to the facial nerve while doing surgery and to give facial nerve block by anesthetics near the stylomastoid foramen we should know its distance from the important anatomical landmarks. So, this study aims to study the location of stylomastoid with respect to nearby anatomical landmarks. Materials and Method The study was performed on 58 dry skulls. Measurements of stylomastoid foramen were taken...
Mon Oct 12, 2020 02:00
Purpose: SHP2 inhibitors offer an appealing and novel approach to inhibit RTK signaling, which is the oncogenic driver in many tumors or is frequently feedback activated in response to targeted therapies including RTKi and MAPKi. We seek to evaluate the efficacy and synergistic mechanisms of combinations with a novel SHP2 inhibitor TNO155 to inform their clinical development. Experimental Design: The combinations of TNO155 with EGFRi, BRAFi, KRASG12Ci, CDK4/6i and anti-PD-1 antibody were tested in...
Mon Oct 12, 2020 16:36
Purpose: Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation leading to cyclin D1 overexpression. Cyclin D1 is a major cell cycle regulator and also regulates transcription, but the impact of cyclin D1-mediated transcriptional dysregulation on MCL pathogenesis remains poorly understood. The aim of this study was to define a cyclin D1-dependent gene expression program and analyze its prognostic value. Experimental design: We integrated genome-wide expression analysis...
Mon Oct 12, 2020 16:36
Purpose: Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is a glycoprotein that has limited expression in normal adult tissues, but is overexpressed in carcinomas of the gastrointestinal tract, the genitourinary and respiratory systems, and breast cancer. As such, CEACAM5 is an attractive target for antibody-based therapies designed to selectively deliver cytotoxic drugs to certain epithelial tumors. Here, we describe preclinical data for a novel antibody-drug conjugate (ADC),...
Mon Oct 12, 2020 16:36
Purpose: Intratumorally injected Clostridium novyi-NT (non-toxic; lackingthe alpha toxin), an attenuated strain of C.novyi, replicates within hypoxic tumor regions resulting in tumor-confined cell lysis and inflammatory response in animals, which warrants clinical investigation. Experimental design: This first-in-humanstudy (NCT01924689) enrolled patients with injectable, treatment-refractory solid tumors to receive a single intratumoral injection ofC. novyi-NTacross 6 dose cohorts (1x104to 3x106spores,...
Mon Oct 12, 2020 16:36
Purpose: Patients with alveolar soft part sarcoma (ASPS) are rare and have few treatment options. We assessed the activity of geptanolimab (GB226), a fully humanized PD-1 antibody, for patients with unresectable, recurrent or metastatic ASPS. Patients and methods: We did this multicentre, single-arm, phase 2 study (Gxplore-005,NCT03623581) in patients aged 18-75 years who had unresectable, recurrent or metastatic ASPS at 11 sites in China. Patients received intravenous geptanolimab (3 mg/kg) every...
Mon Oct 12, 2020 16:36
Purpose: Cancer-associated fibroblasts have emerged to be highly heterogenous and can play multifaced roles in dictating pancreatic ductal adenocarcinoma (PDAC) progression, immunosuppression and therapeutic response, highlighting the need for a deeper understanding of stromal heterogeneity between patients and even within a single tumor. We hypothesized that image analysis of fibroblast subpopulations and collagen in PDAC tissues might guide stroma-based patient stratification to predict clinical...
Mon Oct 12, 2020 16:36
PURPOSE: Lysine-specific demethylase 1 (LSD1) is implicated in multiple tumor types and its expression in cancer stem cells is associated with chemoresistance. CC-90011 is a potent, selective, and reversible oral LSD1 inhibitor. We examined CC-90011 in advanced solid tumors and relapsed/refractory (R/R) non-Hodgkin lymphoma (NHL). EXPERIMENTAL DESIGN: CC-90011-ST-001 (NCT02875223; 2015-005243-13) is a phase I, multicenter, first-in-human dose escalation study. Nine dose levels of CC-90011 (1.25...
Mon Oct 12, 2020 16:36
Purpose: We report the final analysis of JVDL (NCT02789345), which examined the combination of the EGFR TKI osimertinib plus the VEGFR2-directed antibody ramucirumab in patients with T790M-positive EGFR-mutant NSCLC. Experimental Design: This open-label, single-arm phase 1 study enrolled patients with EGFR T790M-positive NSCLC, who had progressed following EGFR TKI but were third-generation EGFR TKI-naïve. A dose-limiting toxicity (DLT) period with as-needed dose de-escalation was followed by an...
Mon Oct 12, 2020 16:36
Purpose: We investigated the value of circulating tumor DNA (ctDNA) in predicting tumor response to neoadjuvant chemoradiotherapy (nCRT), monitoring tumor burden, and prognosing survival in patients with locally advanced rectal cancer (LARC). Experimental Design: This prospective multicenter trial recruited 106 LARC patients for treatment of nCRT followed by surgery. Serial ctDNA were analyzed by NGS at four time points: at baseline, during nCRT, pre-surgery and post-surgery. Results: In total, 1098...
Mon Oct 12, 2020 16:36
AbstractIschaemic heart disease and aortic stenosis are potentially life-threatening conditions. A post-infarct left ventricular aneurysm, when combined with the above, is particularly hazardous. We present a case where all three conditions occurred simultaneously and describe the surgical approach undertaken to attempt correction. The patient underwent aneurysmectomy together with aortic valve replacement and two-vessel coronary artery bypass grafting. The aneurysm was excised with direct linear...
Mon Oct 12, 2020 03:00
A Covid-19 outbreak developed in Lombardy, Veneto and Emilia-Romagna (Italy) at the end of February 2020. Fear of an imminent saturation of available ICU beds generated the notion that rationing of intensive c...
Mon Oct 12, 2020 03:00
Cancer cell metastasis determines disease prognosis. During cancer cell metastasis, the cancer cell and the cancer cell nucleus have to undergo extreme shape changes. To monitor shape changes of cancer cells a...
Mon Oct 12, 2020 03:00
The mosquito transmitted RNA virus dengue virus (DENV) shows significant variation as a consequence of the lack of proofreading activity of the RNA-dependent RNA polymerase that synthesizes new virus genomes. ...
Mon Oct 12, 2020 03:00
Abstract RANKL is biosynthesized as a single-pass transmembrane protein, and soluble molecular species are produced by enzymatic cleavage at the cell surface. Recent studies have revealed that the transmembrane form of RANKL is a major contributor to the induction of mature osteoclasts under physiological conditions in vivo. In osteoblasts and osteocytes, most newly synthesized RANKL forms a protein complex with OPG and is selectively sorted to lysosomes. Only the small proportion...
Mon Oct 12, 2020 03:00
Abstract Introduction Surgical treatment in patients with medication-related osteonecrosis of the jaw (MRONJ) is superior to conservative treatment. However, treatment outcome in patients with periosteal reaction (PR) was significantly poorer than that of those without PR. The purpose of this retrospective study was to analyze the pathophysiology and clinical significance of PR in MRONJ. ...
Mon Oct 12, 2020 03:00
Abstract Introduction Etelcalcetide (Parsabiv®, AMG 416/ONO-5163) is a novel allosteric modulator for the calcium-sensing receptor approved for hemodialysis patients with secondary hyperparathyroidism of uremia. Etelcalcetide reduced parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism of uremia in clinical studies. However, its direct effect on parathyroid hormone secretion in human parathyroid cells...
Mon Oct 12, 2020 03:00
Abstract Introduction Bone mass was recently reported to be related to skeletal muscle mass in humans, and a decrease in cortical bone is a risk factor for osteoporosis. Because circulating myostatin is a factor that primarily controls muscle metabolism, this study examined the role of myostatin in bone mass–skeletal muscle mass interactions. Methods ...
Mon Oct 12, 2020 03:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08746
Mon Oct 12, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08436
Mon Oct 12, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08450
Mon Oct 12, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06652
Mon Oct 12, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05965
Mon Oct 12, 2020 07:00
[ASAP] Spherical Mesoporous Metal Oxides with Tunable Orientation Enabled by Growth Kinetics Control
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07938
Mon Oct 12, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08835
Mon Oct 12, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c10401
Mon Oct 12, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c09781
Mon Oct 12, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06604
Mon Oct 12, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08463
Sun Oct 11, 2020 07:00
Abstract Objective The present study aimed to assess the sleep quality of left-behind women in rural China and exploring the factors associated with sleep quality among rural women. Methods A cross-sectional survey was conducted in Liaoning province, China. A total of 1591 participants were investigated. The sleep quality of rural women was measured...
Mon Oct 12, 2020 03:00
Abstract Purpose This study aimed to examine sleep quality and risk factors associated with sleep disturbance in patients undergoing total joint arthroplasty (TJA) managed with an enhanced recovery protocol from preoperatively until 12 weeks postoperatively in order to provide suggestions for improving the prevention and treatment of sleep disturbance in these patients. ...
Mon Oct 12, 2020 03:00
Abstract Propionic acid, a widely used food preservative and intermediate in the manufacture of various chemicals, is currently produced from petroleum-based chemicals, raising concerns about its long-term sustainability. A key way to make propionic acid more sustainable is through fermentation of low-cost renewable and inedible sugar sources, such as lignocellulosic biomass. To this end, we utilized the cellulosic hydrolysate of sweet sorghum bagasse...
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Abstract The activities and transmissions of microorganisms are closely related to human, and all kinds of diseases caused by pathogenic microorganisms have attracted attention in the world and brought many challenges to human health and public health. The traditional microbial detection technologies have characteristics of longer detection cycle and complicated processes, therefore, which can no longer meet the detection requirements in the field of public...
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Abstract Due to the high mortality rate and an increase in breast cancer incidence, it has been challenging for researchers to come across an effective chemotherapeutic strategy with minimum side effects. Therefore, the need for the development of effective chemotherapeutic drugs is still on the verge. Consequently, we approached a new mechanism to address this issue. The naturally available peptide named latcripin-7A (LP-7A), extracted from a mushroom...
Mon Oct 12, 2020 03:00
Abstract Mycelial adhesion affects cell growth and the production of water-soluble extracellular yellow pigment (EYP) in submerged fermentation with Monascus ruber CGMCC 10910. Two nitrates, NaNO3 and KNO3, were used as nitrogen sources for mitigating mycelial adhesion and improving the production of EYP in this study. The results showed that the adhesion of mycelia in the fermentation broth significantly decreased by adding 5 g/L NaNO3, which prevented mycelia from attaching...
Mon Oct 12, 2020 03:00
Resuscitative endovascular balloon occlusion of the aorta (REBOA) could provide a survival benefit to severely injured patients as it may improve their initial ability to survive the hemorrhagic shock. Althoug...
Mon Oct 12, 2020 03:00
Horm Metab ResDOI: 10.1055/a-1258-8625This review aims to explore, present, and discuss disorders of glucose metabolism implicated in pituitary gland diseases, the appropriate interventions, as well as the therapeutic challenges that may arise. Pituitary pathologies may dysregulate glucose homeostasis, as both the excess and deficiency of various pituitary hormones can affect glucose metabolism. Increased circulating levels of growth hormone, glucocorticoids or prolactin have been shown to mainly...
Mon Oct 12, 2020 02:00
Thorac Cardiovasc Surg Rep 2020; 09: e47-e50DOI: 10.1055/s-0040-1715431 Background Aortic intramural hematoma due to coronary artery dissection is a rare and serious complication during percutaneous coronary intervention. Case Presentation A 78-year-old female patient was admitted for diagnostic coronarography in the context of stable angina. The coronarography showed an asymmetric and significate calcification in the ostium of the right coronary requiring Rotablator (Boston...
Mon Oct 12, 2020 02:00
Thorac Cardiovasc Surg Rep 2020; 09: e29-e32DOI: 10.1055/s-0040-1713731 Background Driveline infection is a serious complication in left ventricular assist device (LVAD) patients. We report the case of a patient who was successfully treated by combining instillation and vacuum-assisted closure (VAC) therapy. Case Description A 65-year-old LVAD patient presented with recurrent driveline infection. Local therapy with VAC therapy in combination with instillation of polyhexanide...
Mon Oct 12, 2020 02:00
Metastasis of renal cell carcinoma to the oral cavity is rare. Renal cell carcinoma metastases are regarded as radioresistant tumors and surgery is recommended. However, since metastatic renal cell carcinoma h...
Mon Oct 12, 2020 03:00
Abstract Following a request from the European Commission, the EFSA assessed the 2018 post‐market environmental monitoring (PMEM) report on the cultivation of Cry1Ab‐expressing maize event MON 810. Like previous years, there was partial compliance with refuge requirements by Spanish farmers growing MON 810 varieties. European and Mediterranean corn borer populations collected from north‐eastern Spain during the 2018 maize growing season and tested for Cry1Ab susceptibility show no symptoms of resistance...
Mon Oct 12, 2020 15:17
To confirm the data reported in our previous studies on the analysis of the variability of the electroglottographic signal in the pathological voice; to evaluate possible differences in variability between organic and functional pathologies; to identify any distinctive/typical EGG patterns for these pathologies.
Mon Oct 12, 2020 03:00
Significant differences exist in anatomical, acoustic, and aerodynamic parameters for nonspeech tasks between culturally and linguistically diverse sample populations. There is a need for expansion of the normative acoustic data to include sociolinguistically diverse groups to ensure that clinical objective measurements are accurately classifying the voice quality of all individuals. This study examined objective measures of voice quality assessment of monolingual speakers of Standard American English...
Mon Oct 12, 2020 03:00
An amendment to this paper has been published and can be accessed via the original article.
Mon Oct 12, 2020 03:00
Extrachromosomal DNA (ecDNA), gene-encoding extrachromosomal particles of DNA, is often present in tumor cells. Recent studies have revealed that oncogene amplification via ecDNA is widespread across a diverse...
Mon Oct 12, 2020 03:00
Remimazolam is an ultra‐short acting benzodiazepine under development for procedural sedation and general anesthesia. Population pharmacokinetic analysis (PopPK) was conducted for remimazolam with arterial and venous samples previously, but results were limited by arterial‐venous concentration differences and inaccurate central volume of distribution (V1) estimates. A new model was developed to describe covariate effects after accounting for arterial‐venous differences. Arterial and venous plasma...
Mon Oct 12, 2020 21:59
Extranodal natural killer/T‐cell lymphoma, nasal type (ENKL) is a rare peripheral T‐cell lymphoma that predominantly occurs in Asian and South American populations. The treatment of ENKL has been a challenge for a long time. This study was conducted to compare the clinical efficacy and safety of cisplatin, dexamethasone, gemcitabine, and pegaspargase (DDGP) and methotrexate, dexamethasone, ifosfamide, L‐asparaginase, and etoposide (SMILE) regimens for relapsed/refractory ENKL and explore the prognostic...
Mon Oct 12, 2020 21:49
Abstract Introduction The purpose of this study is to describe the patterns of practice in Australia and New Zealand for post‐operative radiotherapy in endometrial cancer with cervical stromal involvement. Methods A ten‐item survey including five clinical case scenarios in endometrial cancer with cervical stromal invasion was emailed to Royal Australian and New Zealand College of Radiologists (RANZCR) radiation oncologists in 2018. Responses were analysed to determine relative frequency...
Sun Oct 11, 2020 18:13
This review paper summarises articles regarding orthognathic surgical planning and computerised technology, which were published in two leading national journals in both oral and maxillofacial surgery and orthodontics. This article aims to keep readers up to date with the literature published in this rapidly progressing field.
Mon Oct 12, 2020 03:00
The purpose was to benchmark the unscheduled postoperative return to theatre rate for patients (URTT) undergoing head and neck surgery with free tissue transfer in a UK setting and identify opportunities for quality improvement.
Mon Oct 12, 2020 03:00
We are describing our transcutaneous approach using a nerve stimulator to guide needle insertion and injection to the Lateral Pterygoid muscle (LPM) with Botulinum Toxin. This technique increases significantly the safety and efficacy of the treatment. No additional clinical skills or resources are required for the Maxillofacial Theatre team.
Sun Oct 11, 2020 03:00
Risk factors for post-extraction bleeding in patients with haemophilia: a retrospective cohort study
Many guidelines and studies describe haemostatic management protocols for haemophilia patients, but few have evaluated risk factors for post-extraction bleeding. This retrospective cohort study was performed to investigate risk factors for post-extraction bleeding among haemophilia patients.
Sun Oct 11, 2020 03:00
Submental artery perforator flap (SAPF) is a novel option for the intraoral reconstruction of oral squamous cell carcinoma (OSCC) patients in recent years, but its surgical outcomes have not been well assessed. Herein we compared the surgical outcomes and oncological safety of SAPF reconstruction for median-sized soft-tissue defects after the ablation of primary oral cancer with traditional submental island flaps (SIF) and anterolateral thigh perforator flaps (ALTPF). Fifty-one SAPFs, thirty SIF,...
Sun Oct 11, 2020 03:00
Intralesional sclerotherapy for lymphatic malformations (LMs) has become a modality of choice because of the high morbidity and recurrence rates with surgical excision. Traditionally, the macrocystic variant has shown good results with sclerotherapy. This prospective study was performed to evaluate the role of bleomycin sclerotherapy in the management of different radiological variants of LM. A total of 142 patients were included in this study. The lesions were classified as macrocystic, microcystic,...
Mon Oct 12, 2020 03:00
The publisher regrets that the following corrections were missed during the proofing stage;
Mon Oct 12, 2020 03:00
Abstract Purpose of Review The purpose of this manuscript is to shed light on systematic work-up of a diagnostic challenge such as nummular headache (NH), and to summarize the relevant literature on NH. Recent Findings The specific nature of the shape of the pain site is usually characteristic of NH. Multiple modalities of investigation...
Mon Oct 12, 2020 03:00
Background. Melanoma in blacks is uncommon and exceedingly rare in association with a diabetic ulcer. We present a case of a spindle cell melanoma masquerading as a diabetic ulcer. Case Report. A 57-year-old overweight woman presented to The Maria Holder Diabetes Centre for the Caribbean with a nonhealing ulcer of the right heel after being treated by various primary care physicians over the preceding year. Her general and systematic examinations were unremarkable. There was a cm ulcer with a necrotic...
Mon Oct 12, 2020 18:20
Abstract Nasal amputation and nasomaxillary defects, need to reconstruct the internal lining, osteochondral structure, and external coating of the nose. Authors report a 70‐year‐old male and a 65‐year‐old female treated for nasomaxillary defects (Brown JS, Shaw RJ. The Lancet Oncology 2010;11:1001–1008) due to squamous cell carcinoma (SCC) where the tip of the nose was preserved. A new custom design of the radial forearm free flap (RFFF) consisting on a subcutaneous tissue (SCT) component, a skin...
Mon Oct 12, 2020 21:35
Determination of skeletal maturity and bone age from cervical vertebrae has been well documented. Most methods described use subjective evaluation of morphological characteristics of cervical vertebrae and may...
Mon Oct 12, 2020 03:00
Sun Oct 11, 2020 20:59
Abstract Background/Purpose Frameless stereotactic radiosurgery (SRS) requires dedicated systems to monitor patient motion in order to avoid inaccurate radiation delivery due to involuntary shifts. The purpose of this study is to assess the accuracy and sensitivity of two distinct motion monitoring systems used for frameless SRS. Methods A surface...
Mon Oct 12, 2020 03:00
Zusammenfassung Hintergrund Die Pathogenese beim Plattenepithelkarzinom der Kopf- und Halsregion (HNSCC, „head and neck squamous cell carcinoma“) ist ein komplexer Mehrstufenprozess und resultiert aus der Interaktion von exogenen und endogenen zellulären Prozessen. Jeder Prozess hinterlässt ein charakteristisches Muster an Mutationen auf dem Tumorgenom, eine sog. Tumorsignatur. ...
Mon Oct 12, 2020 03:00
Abstract Introduction Hearing rehabilitation with cochlear implants has attracted increasing interest also for patients with cochleovestibular schwannoma. The authors report their experience with the surgical management of tumors with rare transmodiolar or transmacular extension and outcomes after cochlear implantation (CI). Methods This retrospective case...
Mon Oct 12, 2020 03:00
Abstract In the recent years, using genetically modified T cells has been known as a rapid developing therapeutic approach due to the heartwarming results of clinical trials with patients suffering from relapsed or refractory (R/R) hematologic malignancies such as R/R Acute Lymphoblastic Leukemia (R/R ALL). One of these renowned approaches is Chimeric antigen receptors (CARs). CARs are synthetic receptors with the ability to be expressed on the surface of T lymphocytes and are...
Mon Oct 12, 2020 03:00
Abstract Purpose of Review Although genetic factors clearly play a role in the development of atopic dermatitis (AD), the recent dramatic increase in the prevalence of AD in low- and middle-income countries is not consistent with only a role of genetic factors. These findings strongly suggest that environmental factors may play an important role in the pathogenesis of AD. ...
Mon Oct 12, 2020 03:00
Abstract Purpose of Review COVID-19 (coronavirus viral disease 2019), due to the novel SARS-CoV-2, may present with different types of cutaneous manifestations of varying pathophysiology. During the ongoing pandemic, publications reporting dermatologic findings in COVID-19 continue to emerge. Recent Findings Cutaneous vasculopathy and...
Mon Oct 12, 2020 03:00
Abstract Glycosylation is a critical post/peri‐translational modification required for the appropriate development and function of the immune system. As an example, abnormalities in glycosylation can cause antibody deficiency and reduced lymphocyte signaling, although the phenotype can be complex given the diverse roles of glycosylation. Human MGAT2 encodes N‐acetylglucosaminyltransferase II, which is a critical enzyme in the processing of oligomannose to complex N‐glycans. Complex N‐glycans are...
Mon Oct 12, 2020 12:15
Abstract Prader–Willi syndrome (PWS) is a neurodevelopmental disorder characterized by multiple endocrine, metabolic, respiratory, cognitive, and behavioral/psychiatric symptoms that may lead to severe emotional strain in their caregivers. In this study, we evaluated parenting stress by the Parenting Stress Index‐short form (PSI/SF) and parent‐reported behavioral symptoms by the Child Behavior Checklist (CBCL/6–18) in families of children with PWS. Sixty‐seven home‐resident PWS patients and their...
Mon Oct 12, 2020 12:04
Abstract Pathogenic variants in the homologous and highly conserved genes—CREBBP and EP300—are causal for Rubinstein–Taybi syndrome (RSTS). CREBBP and EP300 encode histone acetyltransferases (HAT) that act as transcriptional co‐activators, and their haploinsufficiency causes the pathology characteristic of RSTS by interfering with global transcriptional regulation. Though generally a well‐characterized syndrome, there is a clear phenotypic spectrum; rare associations have emerged with increasing...
Sun Oct 11, 2020 20:28
Abstract Wiedemann–Steiner syndrome (WDSTS) is a rare autosomal dominant condition caused by heterozygous loss of function variants in the KMT2A (MLL) gene, encoding a lysine N‐methyltransferase that mediates a histone methylation pattern specific for epigenetic transcriptional activation. WDSTS is characterized by a distinctive facial phenotype, hypertrichosis, short stature, developmental delay, intellectual disability, congenital malformations, and skeletal anomalies. Recently, a few patients...
Sun Oct 11, 2020 20:23
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo investigate the risk factors of early postoperative recurrence in patients with single and small (≤3 cm) hepatitis B virus-associated primary hepatocellular carcinoma (HBV-HCC).MethodsThis retrospective study analyzed patients with single and small HBV-HCC. All patients were followed up for 1 year after surgery.ResultsAmong 182 patients, 54 patients had early recurrence within 1 year. The recurrence group had...
Mon Oct 12, 2020 04:41
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo compare the operative and oncologic outcomes between hand-assisted laparoscopic radical nephrectomy (HALRN) and laparoscopic radical nephrectomy (LRN) for large (stage ≥T2b) and locally advanced renal cell carcinoma.MethodsWe retrospectively collected data from patients who underwent HALRN or LRN for stage ≥T2b renal cell carcinoma from January 2011 to January 2018 in our institution. The patients’ demographics,...
Mon Oct 12, 2020 04:40
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveEpidemiological studies on the association of serum oestradiol levels and inflammatory markers have reported inconsistent and conflicting results. Therefore, we investigated the association between serum oestradiol and high-sensitivity C-reactive protein (CRP) levels in women on the basis of their menopausal status.MethodsThis cross-sectional study examined the association between serum oestradiol and CRP levels...
Mon Oct 12, 2020 04:38
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo explore a method for evaluating the bioequivalence of acarbose based on pharmacodynamic parameters using a single-dose, randomized-sequence, three-way crossover study of acarbose test (T) and reference (R) formulations.MethodsBaseline-adjusted, pre-dose value deduction, and direct comparison methods were used to evaluate the geometric T/R ratios and 90% confidence intervals (CIs) of the ln-transformed pharmacodynamic...
Mon Oct 12, 2020 04:36
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo establish a mouse model of bioluminescent Klebsiella pneumoniae-induced lung infection, under different infection states after pretreatment with various dosages of cyclophosphamide (CTX).MethodsA K. pneumoniae strain carrying the luxCDABE operon was used to infect immunocompetent mice (intraperitoneal injection of saline at 4 days and 1 day prior to experimental lung infection) and immunodeficient mice (50 mg/kg...
Mon Oct 12, 2020 04:34
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveWe investigated the associations between cord blood concentration of 25-hydroxyvitamin D [25(OH)D], neonatal outcomes, and the risk of hospitalization during the first year of life.MethodsA total of 402 newborn infants and their mothers were prospectively enrolled and divided in four groups according to season of the year. We determined 25(OH)D serum concentrations from maternal–neonatal pairs at delivery by electrochemiluminescence...
Mon Oct 12, 2020 04:33
Journal of International Medical Research, Volume 48, Issue 10, October 2020. BackgroundCardiac contractility modulation (CCM) is non-excitatory electrical stimulation for improving cardiac function. This study aimed to evaluate the effects of CCM on structural and electrical remodeling in a rabbit model of chronic heart failure (CHF).MethodsThirty rabbits were randomly divided into the sham, CHF, and CCM groups. The CHF model was induced 12 weeks after trans-aortic constriction by pressure unloading...
Mon Oct 12, 2020 04:31
Journal of International Medical Research, Volume 48, Issue 10, October 2020. BackgroundA meta-analysis was conducted to determine whether telomerase reverse transcriptase (TERT) rs2736098 polymorphism was related to the incidence of lung cancer.MethodsWe systematically searched the following three electronic databases: PubMed, Embase, and China National Knowledge Infrastructure (CNKI), for relevant articles. Statistical analysis was performed using the odds ratio (OR) and the corresponding 95% confidence...
Mon Oct 12, 2020 04:30
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo evaluate the clinical performance of cantilevered resin-bonded fixed partial dentures (CRBFPDs) in single tooth replacement in elderly patients at Qingdao Stomatological Hospital.MethodsIn total, 186 CRBFPDs in 153 patients were made from cobalt-chrome alloy. Panavia F 2.0 was used as a luting agent after air-abrasion. Restoration were evaluated at 3-month intervals with regard to function, esthetics, and possible...
Mon Oct 12, 2020 04:20
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Junli Xue, Xuetao Yu, Liqiong Xue, Xiaoxiao Ge, Wei Zhao, Wei Peng
Mon Oct 12, 2020 21:07
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Songtao Yang, Jiaoyue Zhang, Lulu Chen
Mon Oct 12, 2020 21:07
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Ke Ma, Xin Wang, Shiyao Feng, Xueshan Xia, Hongxiu Zhang, Abdul Rahaman, Zhenfei Dong, Yanting Lu, Xiuyang Li, Xiaoyu Zhou, Haijun Zhao, Yuan Wang, Shijun Wang, Zulqarnain Baloch
Mon Oct 12, 2020 21:07
Abstract Epidermolysis bullosa (EB) is the prototypical example of genetic skin fragility disorders. Genotypic heterogeneity, modifier genes, epigenetic, biochemical and environmental factors alter and determine pathogenic traits and, ultimately, the wide and striking phenotypic variability in EB. Besides the primary structural‐functional defect, chronic tissue damage with induction and dysregulation of inflammatory pathways is a common pathogenic mechanism in EB. In localized variants, the inflammatory...
Sun Oct 11, 2020 20:12
Abstract Purpose Adrenocortical carcinoma (ACC) is a rare disease with few therapeutic options. There is an urgency of new effective therapeutic options for these patients. The role of immune checkpoint inhibitors (ICI) in advanced ACC patients is still unclear. Methods We conducted a MEDLINE search using the following string: adrenocortical...
Mon Oct 12, 2020 20:15
Publication date: Available online 11 October 2020Source: Behavioural Brain ResearchAuthor(s): Augustin C. Hennings, Sophia A. Bibb, Jarrod A. Lewis-Peacock, Joseph E. Dunsmoor
Mon Oct 12, 2020 19:44
Publication date: Available online 11 October 2020Source: Behavioural Brain ResearchAuthor(s): Zach McKinnell, Tessa Maze, Alejandro Ramos, Brandon Challans, Bethany Plakke
Mon Oct 12, 2020 19:44
Publication date: Available online 11 October 2020Source: Behavioural Brain ResearchAuthor(s): Mark A. Smith
Mon Oct 12, 2020 19:44
Publication date: Available online 11 October 2020Source: Behavioural Brain ResearchAuthor(s): Gabriella Shab, Elissa K. Fultz, Ariana Page, Michal A. Coelho, Lindsey W. Brewin, Nicholas Stailey, Chelsea N. Brown, Camron D. Bryant, Tod E. Kippin, Karen K. Szumlinski
Mon Oct 12, 2020 19:44
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