Antioxidants, Vol. 9, Pages 978: Substance-P Restores Cellular Activity of ADSC Impaired by Oxidative Stress Antioxidants doi: 10.3390/antiox9100978 Authors: Park Piao Park Hong Oxidative stress induces cellular damage, which accelerates aging and promotes the development of serious illnesses. Adipose-derived stem cells (ADSCs) are novel cellular therapeutic tools and have been applied for tissue regeneration. However, ADSCs from aged and diseased individuals may be affected...
Antioxidants, Vol. 9, Pages 976: Anti-Amnesic Effect of Walnut via the Regulation of BBB Function and Neuro-Inflammation in Aβ1-42-Induced Mice Antioxidants doi: 10.3390/antiox9100976 Authors: Jong Min Kim Uk Lee Jin Yong Kang Seon Kyeong Park Eun Jin Shin Hyun-Jin Kim Chul-Woo Kim Mahn-Jo Kim Ho Jin Heo This study was conducted to assess the protective effect of walnut (Juglans regia L.) extract on amyloid beta (Aβ)1-42-induced institute of cancer research...
Antioxidants, Vol. 9, Pages 975: Designing the Antioxidant Properties of Low-Processed Food Antioxidants doi: 10.3390/antiox9100975 Authors: Michał Świeca Food is the most valuable source of components exhibiting antioxidant properties [...]
Antioxidants, Vol. 9, Pages 977: Protective Effect of Geraniol on Oxidative, Inflammatory and Apoptotic Alterations in Isoproterenol-Induced Cardiotoxicity: Role of the Keap1/Nrf2/HO-1 and PI3K/Akt/mTOR Pathways Antioxidants doi: 10.3390/antiox9100977 Authors: Nancy S. Younis Mohamed S. Abduldaium Maged E. Mohamed Background: Myocardial infarction (MI) is still a major contributor to mortality worldwide, and therefore, searching for new drugs is an urgent priority. Natural products...
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Atmosphere, Vol. 11, Pages 1084: Intensification of Summer Rainfall Extremes over Nigeria during Recent Decades Atmosphere doi: 10.3390/atmos11101084 Authors: Victor Nnamdi Dike Zhao-Hui Lin Chikwem Coleman Ibe Rainfall extremes can cause a significant loss of lives and economic losses in Nigeria. This study aims to investigate the trends of summer rainfall extremes over Nigeria with daily station datasets from 1975 to 2013. Using the rainfall extreme indices recommended by the...
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Bioengineering, Vol. 7, Pages 126: Encapsulation of Hydrophobic Drugs in Shell-by-Shell Coated Nanoparticles for Radio—and Chemotherapy—An In Vitro Study Bioengineering doi: 10.3390/bioengineering7040126 Authors: Stefanie Klein Tobias Luchs Andreas Leng Luitpold Distel Winfried Neuhuber Andreas Hirsch Our research objective was to develop novel drug delivery vehicles consisting of TiO2 and Al2O3 nanoparticles encapsulated by a bilayer shell that allows the reversible...
Bioengineering, Vol. 7, Pages 125: Mesenchymal Stem Cells Coated with Synthetic Bone-Targeting Polymers Enhance Osteoporotic Bone Fracture Regeneration Bioengineering doi: 10.3390/bioengineering7040125 Authors: Yuliya Safarova (Yantsen) Farkhad Olzhayev Bauyrzhan Umbayev Andrey Tsoy Gonzalo Hortelano Tursonjan Tokay Hironobu Murata Alan Russell Sholpan Askarova Osteoporosis is a progressive skeletal disease characterized by reduced bone density leading to bone...
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Biology, Vol. 9, Pages 332: The Function of Drosophila USP14 in Endoplasmic Reticulum Stress and Retinal Degeneration in a Model for Autosomal Dominant Retinitis Pigmentosa Biology doi: 10.3390/biology9100332 Authors: Jung-Eun Park Thị Xuân Thùy Trần Nayoung Park Jeonghun Yeom Kyunggon Kim Min-Ji Kang Endoplasmic reticulum (ER) stress and its adaptive cellular response, the unfolded protein response (UPR), are involved in various diseases including neurodegenerative diseases,...
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Biomedicines, Vol. 8, Pages 409: Interplay between Endoplasmic Reticulum Stress and Large Extracellular Vesicles (Microparticles) in Endothelial Cell Dysfunction Biomedicines doi: 10.3390/biomedicines8100409 Authors: Aisha Osman Tarek Benameur Hesham M. Korashy Asad Zeidan Abdelali Agouni Upon increased demand for protein synthesis, accumulation of misfolded and/or unfolded proteins within the endoplasmic reticulum (ER), a pro-survival response is activated termed unfolded...
Biomedicines, Vol. 8, Pages 406: Monitoring the Redox Status in Multiple Sclerosis Biomedicines doi: 10.3390/biomedicines8100406 Authors: Masaru Tanaka László Vécsei Worldwide, over 2.2 million people suffer from multiple sclerosis (MS), a multifactorial demyelinating disease of the central nervous system. MS is characterized by a wide range of motor, autonomic, and psychobehavioral symptoms, including depression, anxiety, and dementia. The blood, cerebrospinal fluid, and postmortem...
Biomedicines, Vol. 8, Pages 408: Differentially Expressed Proteins in Intra Synovial Compared to Extra Synovial Flexor Tendon Grafts in a Rabbit Tendon Transplantation Model Biomedicines doi: 10.3390/biomedicines8100408 Authors: Simon Farnebo Monica Wiig Björn Holm Bijar Ghafouri Uncomplicated healing of grafts for tendon reconstruction remains an unsolved problem in hand surgery. Results are limited by adhesion formation and decreased strength properties, especially...
Biomedicines, Vol. 8, Pages 407: An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H-Ras-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target Biomedicines doi: 10.3390/biomedicines8100407 Authors: Sung-Jun Hong Jin-Tae Kim Su-Jung Kim Nam-Chul Cho Kyeojin Kim Seungbeom Lee Young-Ger Suh Kyung-Cho Cho Kwang Pyo Kim Young-Joon Surh Signal transducer and activator of transcription 3 (STAT3) is a point of convergence...
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Biomimetics, Vol. 5, Pages 51: Biomimetic Aspects of Oral and Dentofacial Regeneration Biomimetics doi: 10.3390/biomimetics5040051 Authors: Upadhyay Pillai Khayambashi Sabri Lee Tarar Zhou Harb Tran Biomimetic materials for hard and soft tissues have advanced in the fields of tissue engineering and regenerative medicine in dentistry. To examine these recent advances, we searched Medline (OVID) with the key terms “biomimetics”, “biomaterials”,...
Biomimetics, Vol. 5, Pages 50: The Development of a Biomimetic Design Tool for Building Energy Efficiency Biomimetics doi: 10.3390/biomimetics5040050 Authors: Negin Imani Brenda Vale The initial aim of the research was to develop a framework that would enable architects to look for thermoregulation methods in nature as inspiration for designing energy efficient buildings. The thermo-bio-architectural framework (ThBA) assumes designers will start with a thermal challenge in a building...
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Biomolecules, Vol. 10, Pages 1436: Classical Examples of the Concept of the ASIA Syndrome Biomolecules doi: 10.3390/biom10101436 Authors: Vânia Borba Anna Malkova Natalia Basantsova Gilad Halpert Laura Andreoli Angela Tincani Howard Amital Yehuda Shoenfeld Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first introduced in 2011 by Shoenfeld et al. and encompasses a cluster of related immune mediated diseases, which develop among genetically prone...
Biomolecules, Vol. 10, Pages 1435: In Vitro and In Vivo Antioxidant Activity of Agave sisalana Agro-Industrial Residue Biomolecules doi: 10.3390/biom10101435 Authors: Stella Maria Andrade Gomes Barreto Cesar Orlando Muñoz Cadavid Rafael Amir de Oliveira Moura Giovanna Melo Martins Silva Samara Vitória Ferreira de Araújo Jean Antônio Aderaldo da Silva Filho Hugo Alexandre Oliveira Rocha Riva de Paula Oliveira Raquel Brandt Giordani Márcio Ferrari Agave sisalana...
Biomolecules, Vol. 10, Pages 1434: The Polar Lipidome of Cultured Emiliania huxleyi: A Source of Bioactive Lipids with Relevance for Biotechnological Applications Biomolecules doi: 10.3390/biom10101434 Authors: Susana S. Aveiro Tânia Melo Ana Figueiredo Pedro Domingues Hugo Pereira Inês B. Maia Joana Silva M. Rosário Domingues Cláudia Nunes Ana S. P. Moreira Polar lipids from microalgae have aroused greater interest as a natural source of omega-3 (n-3) polyunsaturated...
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Brain Sciences, Vol. 10, Pages 722: Tremor in Multiple Sclerosis—An Overview and Future Perspectives
Brain Sciences, Vol. 10, Pages 722: Tremor in Multiple Sclerosis—An Overview and Future Perspectives Brain Sciences doi: 10.3390/brainsci10100722 Authors: Karim Makhoul Rechdi Ahdab Naji Riachi Moussa A. Chalah Samar S. Ayache Tremor is an important and common symptom in patients with multiple sclerosis (MS). It constituted one of the three core features of MS triad described by Charcot in the last century. Tremor could have a drastic impact on patients’ quality...
Brain Sciences, Vol. 10, Pages 721: Effect of Psycho-Regulatory Massage Therapy on Pain and Depression in Women with Chronic and/or Somatoform Back Pain: A Randomized Controlled Trial Brain Sciences doi: 10.3390/brainsci10100721 Authors: Sabine B.-E. Baumgart Anja Baumbach-Kraft Juergen Lorenz Chronic unspecific back pain (cBP) is often associated with depressive symptoms, negative body perception, and abnormal interoception. Given the general failure of surgery in cBP, treatment...
Brain Sciences, Vol. 10, Pages 720: Brain Oscillatory Activity during Tactile Stimulation Correlates with Cortical Thickness of Intact Areas and Predicts Outcome in Post-Traumatic Comatose Patients Brain Sciences doi: 10.3390/brainsci10100720 Authors: Galina Portnova Irina Girzhova Daria Filatova Vitaliy Podlepich Alina Tetereva Olga Martynova In this study, we have reported a correlation between structural brain changes and electroencephalography (EEG) in response to...
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Cancers, Vol. 12, Pages 2945: Predictive Markers for Malignant Urothelial Transformation in Balkan Endemic Nephropathy: A Case–Control Study Cancers doi: 10.3390/cancers12102945 Authors: Gordana Kocic Jovan Hadzi-Djokic Jovana Cukuranovic-Kokoris Mihajlo Gajic Andrej Veljkovic Rade Cukuranović Dragoslav Basic Ivan Jovanovic Andrija Smelcerovic Balkan endemic nephropathy (BEN) is a chronic tubulointerstitial disease frequently accompanied by urothelial carcinoma...
Cancers, Vol. 12, Pages 2944: The Role of Non-Coding RNAs in Uveal Melanoma Cancers doi: 10.3390/cancers12102944 Authors: Manuel Bande Daniel Fernandez-Diaz Beatriz Fernandez-Marta Cristina Rodriguez-Vidal Nerea Lago-Baameiro Paula Silva-Rodríguez Laura Paniagua María José Blanco-Teijeiro María Pardo Antonio Piñeiro Uveal melanoma (UM) is the most common primary intraocular tumor in adulthood. Approximately 50% of patients develop metastatic disease, which...
Cancers, Vol. 12, Pages 2942: Identification of High-Risk Atypical Meningiomas According to Semantic and Radiomic Features Cancers doi: 10.3390/cancers12102942 Authors: Darius Kalasauskas Andrea Kronfeld Mirjam Renovanz Elena Kurz Petra Leukel Harald Krenzlin Marc A. Brockmann Clemens J. Sommer Florian Ringel Naureen Keric Up to 60% of atypical meningiomas (World Health Organization (WHO) grade II) reoccur within 5 years after resection. However, no clear radiological...
Cancers, Vol. 12, Pages 2941: Impact of COVID-19 Outbreak on Cancer Patient Care and Treatment: Data from an Outpatient Oncology Clinic in Lombardy (Italy) Cancers doi: 10.3390/cancers12102941 Authors: Erica Quaquarini Giuseppe Saltalamacchia Daniele Presti Giulia Caldana Valentina Tibollo Alberto Malovini Raffaella Palumbo Cristina Maria Teragni Emanuela Balletti Ludovica Mollica Elisa Biscaldi Mara Frascaroli Antonio Bernardo Federico Sottotetti ...
Cancers, Vol. 12, Pages 2940: Manipulation of Glucose Availability to Boost Cancer Immunotherapies Cancers doi: 10.3390/cancers12102940 Authors: Federica Marchesi Debora Vignali Beatrice Manini Alessandra Rigamonti Paolo Monti The orchestration of T cell responses is intimately linked to the execution of metabolic processes, both in homeostasis and disease. In cancer tissues, metabolic alterations that characterize malignant transformation profoundly affect the composition...
Cancers, Vol. 12, Pages 2943: No Impact of Smoking Status on Breast Cancer Tumor Infiltrating Lymphocytes, Response to Neoadjuvant Chemotherapy and Prognosis Cancers doi: 10.3390/cancers12102943 Authors: Vanille Simon Lucie Laot Enora Laas Sonia Rozette Julien Guerin Thomas Balezeau Marion Nicolas Jean-Yves Pierga Florence Coussy Marick Laé Diane De Croze Beatriz Grandal Judith Abecassis Elise Dumas Florence Lerebours Fabien Reyal Anne-Sophie...
Cancers, Vol. 12, Pages 2932: Nrf2 in Neoplastic and Non-Neoplastic Liver Diseases Cancers doi: 10.3390/cancers12102932 Authors: Claudia Orrù Silvia Giordano Amedeo Columbano Activation of the Keap1/Nrf2 pathway, the most important cell defense signal, triggered to neutralize the harmful effects of electrophilic and oxidative stress, plays a crucial role in cell survival. Therefore, its ability to attenuate acute and chronic liver damage, where oxidative stress represents the key...
Cancers, Vol. 12, Pages 2938: Clonal Evolution and Timing of Metastatic Colorectal Cancer Cancers doi: 10.3390/cancers12102938 Authors: Sarah Siraj Tariq Masoodi Abdul K. Siraj Saud Azam Zeeshan Qadri Saeeda O. Ahmed Wafaa N. AlBalawy Khadija A. Al-Obaisi Sandeep K. Parvathareddy Hadeel M. AlManea Hussah F. AlHussaini Alaa Abduljabbar Samar Alhomoud Fouad H. Al-Dayel Fowzan S. Alkuraya Khawla S. Al-Kuraya Colorectal cancer (CRC) is the third...
Cancers, Vol. 12, Pages 2934: Integrative Data Augmentation with U-Net Segmentation Masks Improves Detection of Lymph Node Metastases in Breast Cancer Patients Cancers doi: 10.3390/cancers12102934 Authors: Yong Won Jin Shuo Jia Ahmed Bilal Ashraf Pingzhao Hu Deep learning models have potential to improve performance of automated computer-assisted diagnosis tools in digital histopathology and reduce subjectivity. The main objective of this study was to further improve diagnostic...
Cancers, Vol. 12, Pages 2935: Comprehensive Exome Analysis of Immunocompetent Metastatic Head and Neck Cancer Models Reveals Patient Relevant Landscapes Cancers doi: 10.3390/cancers12102935 Authors: Hui Li Hoi-Lam Ngan Yuchen Liu Helen Hoi Yin Chan Peony Hiu Yan Poon Chun Kit Yeung Yibing Peng Wai Yip Lam Benjamin Xiaoyi Li Yukai He Vivian Wai Yan Lui Immunocompetent metastatic head and neck cancer (HNC) models, although scarce, can help understanding cancer...
Cancers, Vol. 12, Pages 2937: A Novel Orthotopic Patient-Derived Xenograft Model of Radiation-Induced Glioma Following Medulloblastoma Cancers doi: 10.3390/cancers12102937 Authors: Jacqueline P. Whitehouse Meegan Howlett Hilary Hii Chelsea Mayoh Marie Wong Paulette Barahona Pamela Ajuyah Christine L. White Molly K. Buntine Jason M. Dyke Sharon Lee Santosh Valvi Jason Stanley Clara Andradas Brooke Carline Mani Kuchibhotla Paul G. Ekert Mark...
Cancers, Vol. 12, Pages 2936: The In Vitro and In Vivo Anticancer Properties of Chalcone Flavokawain B through Induction of ROS-Mediated Apoptotic and Autophagic Cell Death in Human Melanoma Cells Cancers doi: 10.3390/cancers12102936 Authors: You-Cheng Hseu Yu-Chi Chiang Yugandhar Vudhya Gowrisankar Kai-Yuan Lin Sheng-Teng Huang Sirjana Shrestha Geng-Ruei Chang Hsin-Ling Yang Melanoma is the most prevalent type of skin cancer with high mortality rates. This study...
Cancers, Vol. 12, Pages 2939: Effect of Citric Acid Cycle Genetic Variants and Their Interactions with Obesity, Physical Activity and Energy Intake on the Risk of Colorectal Cancer: Results from a Nested Case-Control Study in the UK Biobank Cancers doi: 10.3390/cancers12102939 Authors: Sooyoung Cho Nan Song Ji-Yeob Choi Aesun Shin Colorectal cancer is a common malignancy worldwide. Physical activity and a healthy diet contribute to energy balance and have been recommended for...
Cancers, Vol. 12, Pages 2931: Estrogen Regulation of mTOR Signaling and Mitochondrial Function in Invasive Lobular Carcinoma Cell Lines Requires WNT4 Cancers doi: 10.3390/cancers12102931 Authors: Madeleine T. Shackleford Deviyani M. Rao Evelyn K. Bordeaux Hannah M. Hicks Christina G. Towers Joseph L. Sottnik Steffi Oesterreich Matthew J. Sikora Invasive lobular carcinoma of the breast (ILC) is strongly estrogen-driven and represents a unique context for estrogen...
Cancers, Vol. 12, Pages 2933: Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia Cancers doi: 10.3390/cancers12102933 Authors: Pierre-Luc Mouchel Nizar Serhan Rémy Betous Thomas Farge Estelle Saland Philippe De Medina Jean-Sébastien Hoffmann Jean-Emmanuel Sarry Marc Poirot Sandrine Silvente-Poirot Christian Récher Dendrogenin A (DDA), a mammalian cholesterol metabolite with tumor suppressor properties, has recently been...
Cancers, Vol. 12, Pages 2928: The Impact of Next Generation Sequencing in Cancer Research Cancers doi: 10.3390/cancers12102928 Authors: Katia Nones Ann-Marie Patch Next generation sequencing (NGS) describes the technical revolution that enabled massively parallel sequencing of fragmented nucleic acids, thus making possible our current genomic understanding of cancers [...]
Cancers, Vol. 12, Pages 2929: Drug Resistance and Novel Therapies in Cancers Cancers doi: 10.3390/cancers12102929 Authors: Zhixiang Wang n/a
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Cells, Vol. 9, Pages 2275: Age-Dependent Maturation of iPSC-CMs Leads to the Enhanced Compartmentation of β2AR-cAMP Signalling Cells doi: 10.3390/cells9102275 Authors: Alveera Hasan Neda Mohammadi Aisha Nawaz Thusharika Kodagoda Ivan Diakonov Sian E. Harding Julia Gorelik The ability to differentiate induced-pluripotent stem cells into cardiomyocytes (iPSC-CMs) has opened up novel avenues for potential cardiac therapies. However, iPSC-CMs exhibit a range of somewhat...
Cells, Vol. 9, Pages 2274: Special Issue on “New Advances in Cyclic AMP Signalling”—An Editorial Overview Cells doi: 10.3390/cells9102274 Authors: Stephen John Yarwood The cyclic nucleotides 3′,5′-adenosine monophosphate (cyclic AMP) signalling system underlies the control of many biological events and disease processes in man. Cyclic AMP is synthesised by adenylate cyclase (AC) enzymes in order to activate effector proteins and it is then degraded by phosphodiesterase...
Cells, Vol. 9, Pages 2276: Understanding IGF-II Action through Insights into Receptor Binding and Activation Cells doi: 10.3390/cells9102276 Authors: Andrew J. Blyth Nicholas S. Kirk Briony E. Forbes The insulin-like growth factor (IGF) system regulates metabolic and mitogenic signaling through an intricate network of related receptors and hormones. IGF-II is one of several hormones within this system that primarily regulates mitogenic functions and is especially important during...
Cells, Vol. 9, Pages 2273: K+ Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell Migration, Focal Adhesion Dynamics and Spreading through Modulation of Ca2+ Signaling and Rac1 Activity Cells doi: 10.3390/cells9102273 Authors: Jimena Canales Pablo Cruz Nicolás Díaz Denise Riquelme Elías Leiva-Salcedo Oscar Cerda Cell migration is critical for several physiological and pathophysiological processes. It depends on the coordinated action of kinases, phosphatases,...
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Challenges, Vol. 11, Pages 25: The Potential Effects of Short-Chain Fatty Acids on the Epigenetic Regulation of Innate Immune Memory Challenges doi: 10.3390/challe11020025 Authors: Raphael Watt Kimberley Parkin David Martino The regulation of innate immunity is substantially more ‘plastic’ than previously appreciated. Innate immune memory (manifested through trained immunity and tolerance) is a recently described epigenetic phenomenon that is a model example,...
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Children, Vol. 7, Pages 178: Tracking Children’s Physical Activity Patterns across the School Year: A Mixed-Methods Longitudinal Case Study Children doi: 10.3390/children7100178 Authors: Irfan Khawaja Lorayne Woodfield Peter Collins Adam Benkwitz Alan Nevill Despite the breadth of health benefits associated with regular physical activity (PA), many children in the UK are not sufficiently active enough to meet health guidelines, and tend to become less active as they mature...
Children, Vol. 7, Pages 179: Talking to Children and Families about Chronic Pain: The Importance of Pain Education—An Introduction for Pediatricians and Other Health Care Providers Children doi: 10.3390/children7100179 Authors: Koechlin Locher Prchal Chronic pain in children and adolescents is a common and debilitating health problem. This narrative review will give a brief overview on what pediatric chronic pain is and what treatment options there are for children and adolescents....
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Climate, Vol. 8, Pages 116: Assessing Property Level Economic Impacts of Climate in the US, New Insights and Evidence from a Comprehensive Flood Risk Assessment Tool Climate doi: 10.3390/cli8100116 Authors: Saman Armal Jeremy R. Porter Brett Lingle Ziyan Chu Michael L. Marston Oliver E. J. Wing Hurricanes and flood-related events cause more direct economic damage than any other type of natural disaster. In the United States, that damage totals more than USD 1 trillion...
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Dentistry Journal, Vol. 8, Pages 117: Superficial Temporal Artery Perforator Flap: Indications, Surgical Outcomes, and Donor Site Morbidity Dentistry Journal doi: 10.3390/dj8040117 Authors: Raffaele Rauso Giovanni Francesco Nicoletti Enrico Sesenna Carmelo Lo Faro Fabrizio Chirico Romolo Fragola Giorgio Lo Giudice Gianpaolo Tartaro The aim of this retrospective case series was to discuss indications, surgical outcomes, and donor site morbidity in the use of superficial...
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Diagnostics, Vol. 10, Pages 810: Liquid Biopsy in Pediatric Renal Cancer: Stage I and Stage IV Cases Compared Diagnostics doi: 10.3390/diagnostics10100810 Authors: Rossi Zin Facchinetti Poggiana Tombolan Affinita Bonvini Santoro Schiavi Bisogno Zamarchi Pediatric renal cancer is rare, and robust evidence for treatment recommendations is lacking. In the perspective of personalized medicine, clinicians need new biomarkers to improve risk stratification...
Diagnostics, Vol. 10, Pages 809: Clinical and Biochemical Predictors of Nonalcoholic Fatty Liver Disease among Type 2 Diabetes Mellitus Patients at Primary Health Care Level in South Western Saudi Arabia Diagnostics doi: 10.3390/diagnostics10100809 Authors: Suliman M. Al Humayed Abdullah A. Al Sabaani Ahmed A. Mahfouz Nabil J. Awadalla Mustafa Jafar Musa Ayyub Patel Objectives: To predict the role of different clinical and biochemical parameters in identifying nonalcoholic...
Diagnostics, Vol. 10, Pages 808: The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation Diagnostics doi: 10.3390/diagnostics10100808 Authors: Yuichi Akama Naoko Satoh-Takayama Eiji Kawamoto Atsushi Ito Arong Gaowa Eun Jeong Park Hiroshi Imai Motomu Shimaoka Septic shock/severe sepsis is a deregulated host immune system response to infection that leads to life-threatening organ dysfunction. Lung inflammation...
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Environments, Vol. 7, Pages 88: The Impact of Tourism Activity on Coastal Biodiversity: A Case Study at Praia da Cova Redonda (Algarve—Portugal) Environments doi: 10.3390/environments7100088 Authors: Leonel J. R. Nunes Mauro A. M. Raposo Carlos J. Pinto Gomes Tourism activity has a very significant weight in the world economy, even being the main activity responsible for the export of many countries, in the form of providing services to foreign citizens. In mainland Portugal, the...
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Foods, Vol. 9, Pages 1446: Evolution of VOC and Sensory Characteristics of Stracciatella Cheese as Affected by Different Preservatives Foods doi: 10.3390/foods9101446 Authors: Giuseppe Natrella Graziana Difonzo Maria Calasso Giuseppe Costantino Francesco Caponio Michele Faccia Undesired volatile organic compounds (VOCs) can negatively affect the flavor of fresh food products; especially those characterized by a mild and delicate aroma. Finding connections between chemical...
Foods, Vol. 9, Pages 1445: Olive Fruit Refrigeration during Prolonged Storage Preserves the Quality of Virgin Olive Oil Extracted Therefrom Foods doi: 10.3390/foods9101445 Authors: Karolina Brkić Brkić Bubola Marina Lukić Anja Novoselić Marin Krapac Igor Lukić With the aim to investigate the influence of post-harvest olive fruit storage temperatures on virgin olive oil production parameters, composition and quality, Istarska bjelica (IB) and Rosinjola (RO) fruits were stored...
Foods, Vol. 9, Pages 1444: Effect of High Hydrostatic Pressure Processing on the Chemical Characteristics of Different Lamb Cuts Foods doi: 10.3390/foods9101444 Authors: Kevin Kantono Nazimah Hamid Indrawati Oey Yan Chao Wu Qianli Ma Mustafa Farouk Diksha Chadha The non-thermal high-pressure processing (HPP) technique has been used to increase the shelf life of food without compromising their nutritional and sensory qualities. This study aims to explore the potential...
Foods, Vol. 9, Pages 1443: Effect of Interaction between Mealworm Protein and Myofibrillar Protein on the Rheological Properties and Thermal Stability of the Prepared Emulsion Systems Foods doi: 10.3390/foods9101443 Authors: Tae-Kyung Kim Min Hyeock Lee Hae In Yong Samooel Jung Hyun-Dong Paik Hae Won Jang Yun-Sang Choi In this study, we investigated the effect of replacing myofibrillar protein (pork ham) with edible insect proteins (Tenebrio molitor L.) in meat emulsion...
Foods, Vol. 9, Pages 1442: Edible Seaweeds and Spirulina Extracts for Food Application: In Vitro and In Situ Evaluation of Antimicrobial Activity towards Foodborne Pathogenic Bacteria Foods doi: 10.3390/foods9101442 Authors: Francesco Martelli Martina Cirlini Camilla Lazzi Erasmo Neviani Valentina Bernini Research is more and more focused on studying and selecting food preservatives of natural origin. In this scenario, algae are an excellent source of bioactive compounds,...
Foods, Vol. 9, Pages 1441: Insight into the Effects of Sous Vide on Cathepsin B and L Activities, Protein Degradation and the Ultrastructure of Beef Foods doi: 10.3390/foods9101441 Authors: Yantao Yin Jailson Pereira Lei Zhou Jose M. Lorenzo Xiaona Tian Wangang Zhang This study aimed to evaluate the effects of sous vide cooking (SV) on beef tenderness and its underlying potential mechanism. Beef semimembranosus (SM) were subjected to SV treatments at 45 °C, 55...
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Geriatrics, Vol. 5, Pages 75: Systematic Dysphagia Screening of Elderly Persons in the Emergency Department—A Feasibility Study Geriatrics doi: 10.3390/geriatrics5040075 Authors: Dorte Melgaard Line R. Sørensen Diana Lund Peter Leutscher Marc Ludwig Identification of elderly patients in risk of dysphagia as early as possible upon hospital admission seems warranted due to the risk of aspiration pneumonia, dehydration, length of stay, and increased mortality. This study aimed...
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Healthcare, Vol. 8, Pages 395: Reasons for Turnover Intention among Direct Care Workers in Korea’s Long-Term Care Insurance Healthcare doi: 10.3390/healthcare8040395 Authors: Yongho Chon Yun-Young Kim This study explored reasons for turnover intention among direct care workers under the Korean long-term care insurance (LTCI) system. The author conducted semi-structured interviews with 19 care workers. The study revealed four main themes underlying the intention of care workers to...
Healthcare, Vol. 8, Pages 396: The Role of Perceived Social Support in Assessing Posttraumatic Stress Disorder and Mental Health-Related Quality of Life in Veterans Healthcare doi: 10.3390/healthcare8040396 Authors: Jukić Lukinac Požgain Talapko Jukić Filaković This study aims to establish the effect of self-perceived social support on the intensity of Post-Traumatic Stress Disorder (PTSD) symptoms and Mental Health-Related Quality of Life (MHRQoL) in veterans more...
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Heritage, Vol. 3, Pages 1124-1147: Analysis of Leonardo da Vinci’s Architecture through Parametric Modeling: A Method for the Digital Reconstruction of the Centrally Planned Churches Depicted in Ms. B Heritage doi: 10.3390/heritage3040063 Authors: Beatrice Vaienti Fabrizio Ivan Apollonio Marco Gaiani Among many other themes, Leonardo da Vinci’s Manuscript B contains several drawings of centrally planned churches, some of which are represented using a plan view paired...
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IJERPH, Vol. 17, Pages 7428: “You’ve Got to Pick Your Battles”: A Mixed-Methods Investigation of Physical Activity Counselling and Referral within General Practice International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207428 Authors: Benjamin J. R. Buckley Stephanie J. Finnie Rebecca C. Murphy Paula M. Watson One in four people say they would be more active if advised by a general practitioner (GP), yet 72% of GPs do not discuss physical activity...
IJERPH, Vol. 17, Pages 7427: Interaction Effects of Physical and Psychosocial Working Conditions on Risk for Sickness Absence: A Prospective Study of Nurses and Care Assistants in Sweden International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207427 Authors: Magnus Helgesson Staffan Marklund Klas Gustafsson Gunnar Aronsson Constanze Leineweber Employees in health and social care are often simultaneously exposed to both physical and psychosocial...
IJERPH, Vol. 17, Pages 7416: Impact of Age-Related Vision Changes on Driving International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207416 Authors: Sonia Ortiz-Peregrina Carolina Ortiz Miriam Casares-López José J. Castro-Torres Luis Jiménez del Barco Rosario G. Anera Aging leads to impaired visual function, which can affect driving—a very visually demanding task—and has a direct impact on an individual’s quality...
IJERPH, Vol. 17, Pages 7426: Effect of Psychological Inflexibility on Depressive Symptoms and Sleep Disturbance Among Japanese Young Women with Chronic Pain International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207426 Authors: Kato Background: Psychological inflexibility based on an acceptance and commitment therapy model is theoretically well-established as a process to exacerbate psychological distress, such as depressive symptoms and sleep disturbance....
IJERPH, Vol. 17, Pages 7425: Menstrual Problems and Lifestyle Among Spanish University Women International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207425 Authors: Fernández-Martínez Fernández-Villa Amezcua-Prieto Suárez-Varela Mateos-Campos Ayán-Pérez Torre Ortíz-Moncada Almaraz Abellán Delgado-Rodríguez Alonso-Molero Martínez-Ruíz Llopis-Morales Juan Carral Martín-Peláez Alguacil Menstrual...
IJERPH, Vol. 17, Pages 7423: Adolescent Tobacco Exposure in 31 Latin American Cities before and after the Framework Convention for Tobacco Control International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207423 Authors: Francisco-Javier Prado-Galbarro Amy H. Auchincloss Carolina Pérez-Ferrer Sharon Sanchez-Franco Tonatiuh Barrientos-Gutierrez Our objective was to describe the prevalence and changes in tobacco use and tobacco control policies...
IJERPH, Vol. 17, Pages 7424: Influences of Migrant Construction Workers’ Environmental Risk Perception on their Physical and Mental Health: Evidence from China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207424 Authors: Jiang Luo Yang Employing Chinese General Social Survey 2013 data (N = 678), this study examines the influences of migrant construction workers’ environmental risk perception (ERP) on their physical and mental...
IJERPH, Vol. 17, Pages 7421: Public Spaces as Knowledgescapes: Understanding the Relationship between the Built Environment and Creative Encounters at Dutch University Campuses and Science Parks International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207421 Authors: Soares Weitkamp Yamu The success of university campuses depends on the interrelations between creative encounters and the built environment, conceptualised here as spatial affordances...
IJERPH, Vol. 17, Pages 7420: Recognizing Emotions through Facial Expressions: A Largescale Experimental Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207420 Authors: Artemisa R. Dores Fernando Barbosa Cristina Queirós Irene P. Carvalho Mark D. Griffiths Experimental research examining emotional processes is typically based on the observation of images with affective content, including facial expressions. Future studies will benefit...
IJERPH, Vol. 17, Pages 7422: Do Long-Run Disasters Promote Human Capital in China?—The Impact of 500 Years of Natural Disasters on County-Level Human-Capital Accumulation International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207422 Authors: Zhang Ruan Is there a relationship between the frequency of regional natural disasters and long-term human-capital accumulation? This article investigates the long-run causality between natural calamities and...
IJERPH, Vol. 17, Pages 7418: Effect of Income Level and Perception of Susceptibility and Severity of COVID-19 on Stay-at-Home Preventive Behavior in a Group of Older Adults in Mexico City International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207418 Authors: Irigoyen-Camacho Velazquez-Alva Zepeda-Zepeda Cabrer-Rosales Lazarevich Castaño-Seiquer Early information on public health behaviors adopted to prevent the spread of coronavirus...
IJERPH, Vol. 17, Pages 7417: Mental Well-Being (Depression, Loneliness, Insomnia, Daily Life Fatigue) during COVID-19 Related Home-Confinement—A Study from Poland International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207417 Authors: Bartoszek Walkowiak Bartoszek Kardas The COVID-19 pandemic is a great threat to both physical and mental health as it may lead to psychological stress connected with an economic crisis, threat of unemployment,...
IJERPH, Vol. 17, Pages 7419: Can Childcare Work Be Designed to Promote High Intensity Physical Activity for Improved Fitness and Health? A Proof of Concept Study of the Goldilocks Principle International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207419 Authors: Lerche Vilhelmsen Schmidt Kildedal Launbo Munch Lidegaard Jacobsen Rasmussen Mathiassen Straker Holtermann Childcare workers are reported to have high...
IJERPH, Vol. 17, Pages 7415: A Countrywide Survey in Saudi Arabia Regarding the Knowledge and Attitude of Health Care Professionals about Coronavirus Disease (COVID-19) International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207415 Authors: Alduraywish Srivastava Shrivastava Sghaireen Alsharari Al-Johani Alam Coronavirus disease (COVID-19) has emerged as a pandemic. The updated knowledge and a positive attitude of health care professionals...
IJERPH, Vol. 17, Pages 7413: Group Membership and Social and Personal Identities as Psychosocial Coping Resources to Psychological Consequences of the COVID-19 Confinement International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207413 Authors: Carlos-María Alcover Fernando Rodríguez Yolanda Pastor Helena Thomas Mayelin Rey José Luis del Barrio The confinement imposed by measures to deal with the COVID-19 pandemic may in the short and medium...
IJERPH, Vol. 17, Pages 7412: Association between Urinary Triclosan and Serum Testosterone Levels in U.S. Adult Males from NHANES, 2011–2012 International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207412 Authors: Judy Yan Michael A. Joseph Simone A. Reynolds Laura A. Geer Triclosan was introduced into the market in the 1970s and has since been used as an antimicrobial agent in a diverse array of consumer and personal care products. Although it has...
IJERPH, Vol. 17, Pages 7411: A Dyadic Perspective of Felt Security: Does Partners’ Security Buffer the Effects of Actors’ Insecurity on Daily Commitment? International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207411 Authors: Sasaki Overall Interdependence and attachment models have identified felt security as a critical foundation for commitment by orientating individuals towards relationship-promotion rather than self-protection. However, partners’...
IJERPH, Vol. 17, Pages 7414: Carbon Footprint of a Port Infrastructure from a Life Cycle Approach International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207414 Authors: Saravia de los Reyes Fernández-Sánchez Esteban Rodríguez One of the most important consequences caused by the constant development of human activity is the uncontrolled generation of greenhouse gases (GHG). The main gases (CO2, CH4, and N2O) are illustrated by the carbon footprint....
IJERPH, Vol. 17, Pages 7405: Interventions to Improve Health among Reproductive-Age Women of Low Health Literacy: A Systematic Review International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207405 Authors: Rafael Vila-Candel Francisco Miguel Martínez-Arnau Juan María de la Cámara-de las Heras Enrique Castro-Sánchez Pilar Pérez-Ros Background: Limited or low health literacy (HL) has been associated with poor health outcomes, including inadequate...
IJERPH, Vol. 17, Pages 7406: The Influence of COVID-19 Isolation on Physical Activity Habits and Its Relationship with Convergence Insufficiency International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207406 Authors: Mon-López Bernardez-Vilaboa Fernandez-Balbuena Sillero-Quintana The purpose of this work is to evaluate the effects of confinement due to COVID-19 isolation on visual function, considering insufficient convergence as one of the...
IJERPH, Vol. 17, Pages 7409: Comparing the Use of Spatially Explicit Indicators and Conventional Indicators in the Evaluation of Healthy Cities: A Case Study in Shenzhen, China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207409 Authors: Jun Yang Xiangyu Luo Yixiong Xiao Shaoqing Shen Mo Su Yuqi Bai Peng Gong Various indicator systems have been developed to monitor and assess healthy cities. However, few of them contain spatially...
IJERPH, Vol. 17, Pages 7408: Bruxism, Related Factors and Oral Health-Related Quality of Life Among Vietnamese Medical Students International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207408 Authors: Phuong Ngoc Linh Duc Tra Anh Although bruxism is a common issue with a high prevalence, there has been a lack of epidemiological data about bruxism in Vietnam. This cross-sectional study aimed to determine the prevalence and associated...
IJERPH, Vol. 17, Pages 7404: Analysis of Instagram® Posts Referring to Cleft Lip International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207404 Authors: Magdalena Sycinska-Dziarnowska Piotr Stepien Joanna Janiszewska-Olszowska Katarzyna Grocholewicz Maciej Jedlinski Roberta Grassi Marta Mazur Background: Social media has become a source of medical information. Cleft lip and palate is a visible congenital anomaly. The aim of the study was...
IJERPH, Vol. 17, Pages 7407: Towards Holistic Governance of China’s E-Waste Recycling: Evolution of Networked Policies International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207407 Authors: Yang Miao Wu Duan Yang Tang Electronic products are being updated and replaced much faster and there is therefore an increasing growth in electronic waste (e-waste). In order to promote professional recycling of e-waste, the relevant government...
IJERPH, Vol. 17, Pages 7410: Influence of Abdominal Hollowing Maneuver on the Core Musculature Activation during the Prone Plank Exercise International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207410 Authors: García-Jaén Cortell-Tormo Hernández-Sánchez Tortosa-Martínez This cross-sectional study of repeated measures investigated whether integrating the abdominal hollowing maneuver (AHM) into the prone plank performance is an effective strategy...
IJERPH, Vol. 17, Pages 7403: Searching for New Directions for Energy Policy: Testing Three Causal Models of Risk Perception, Attitude, and Behavior in Nuclear Energy Context International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17207403 Authors: Byoung Joon Kim Seoyong Kim Sunhee Kim Although many risk studies investigate perceptions, attitudes, and behaviors, the causal relationships among them have not yet been verified. Thus, further investigations...
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IJMS, Vol. 21, Pages 7525: ALS-Related Mutant SOD1 Aggregates Interfere with Mitophagy by Sequestering the Autophagy Receptor Optineurin International Journal of Molecular Sciences doi: 10.3390/ijms21207525 Authors: Yeong Jin Tak Ju-Hwang Park Hyangshuk Rhim Seongman Kang Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive demise of motor neurons. One of the causes of familial ALS is the mutation of the gene encoding superoxide...
IJMS, Vol. 21, Pages 7523: Chrysoeriol Prevents TNFα-Induced CYP19 Gene Expression via EGR-1 Downregulation in MCF7 Breast Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21207523 Authors: Dong Yeong Min Euitaek Jung Sung Shin Ahn Young Han Lee Yoongho Lim Soon Young Shin Estrogen overproduction is closely associated with the development of estrogen receptor-positive breast cancer. Aromatase, encoded by the cytochrome P450 19 (CYP19) gene, regulates...
IJMS, Vol. 21, Pages 7524: p38β and Cancer: The Beginning of the Road International Journal of Molecular Sciences doi: 10.3390/ijms21207524 Authors: Olga Roche Diego M. Fernández-Aroca Elena Arconada-Luque Natalia García-Flores Liliana F. Mellor María José Ruiz-Hidalgo Ricardo Sánchez-Prieto The p38 mitogen-activated protein kinase (MAPK) signaling pathway is implicated in cancer biology and has been widely studied over the past two decades as a potential therapeutic...
IJMS, Vol. 21, Pages 7521: Targeted Amino Acid Substitutions in a Trichoderma Peptaibol Confer Activity Against Fungal Plant Pathogens and Protect Host Tissues from Botrytis cinerea Infection International Journal of Molecular Sciences doi: 10.3390/ijms21207521 Authors: Marta De De Zotti Luca Sella Angela Bolzonello Laura Gabbatore Cristina Peggion Alessandro Bortolotto Ibrahim Elmaghraby Silvio Tundo Francesco Favaron Fungal species belonging to the Trichoderma...
IJMS, Vol. 21, Pages 7522: Novel Molecular Markers in Glioblastoma—Benefits of Liquid Biopsy International Journal of Molecular Sciences doi: 10.3390/ijms21207522 Authors: Birkó Nagy Klekner Virga : Glioblastoma is a primary Central Nervous System (CNS) malignancy with poor survival. Treatment options are scarce and despite the extremely heterogeneous nature of the disease, clinicians lack prognostic and predictive markers to characterize patients with different outcomes....
IJMS, Vol. 21, Pages 7520: The Lethal(2)-Essential-for-Life [L(2)EFL] Gene Family Modulates Dengue Virus Infection in Aedes aegypti International Journal of Molecular Sciences doi: 10.3390/ijms21207520 Authors: Lucky R. Runtuwene Shuichi Kawashima Victor D. Pijoh Josef S. B. Tuda Kyoko Hayashida Junya Yamagishi Chihiro Sugimoto Shoko Nishiyama Michihito Sasaki Yasuko Orba Hirofumi Sawa Tomohiko Takasaki Anthony A. James Takashi Kobayashi Yuki Eshita...
IJMS, Vol. 21, Pages 7506: 1-Cinnamoyltrichilinin from Melia azedarach Causes Apoptosis through the p38 MAPK Pathway in HL-60 Human Leukemia Cells International Journal of Molecular Sciences doi: 10.3390/ijms21207506 Authors: Hoibin Jeong SeonJu Park Seo-Young Kim Su-Hyeon Cho Myeong Seon Jeong Song-Rae Kim Jong Bok Seo Seung Hyun Kim Kil-Nam Kim Acute myeloid leukemia (AML) is an aggressive type of human leukemia with a low survival rate, and its complete remission...
IJMS, Vol. 21, Pages 7519: Globoids and Phytase: The Mineral Storage and Release System in Seeds International Journal of Molecular Sciences doi: 10.3390/ijms21207519 Authors: Claus Krogh Madsen Henrik Brinch-Pedersen Phytate and phytases in seeds are the subjects of numerous studies, dating back as far as the early 20th century. Most of these studies concern the anti-nutritional properties of phytate, and the prospect of alleviating the effects of phytate with phytase. As reasonable...
IJMS, Vol. 21, Pages 7517: GPR4 Knockout Improves the Neurotoxin-Induced, Caspase-Dependent Mitochondrial Apoptosis of the Dopaminergic Neuronal Cell International Journal of Molecular Sciences doi: 10.3390/ijms21207517 Authors: Md Ezazul Haque Mahbuba Akther Shofiul Azam Dong-Kug Choi In-Su Kim In Parkinson’s disease, mitochondrial oxidative stress-mediated apoptosis is a major cause of dopaminergic neuronal loss in the substantia nigra (SN). G protein-coupled...
IJMS, Vol. 21, Pages 7516: Luminescence of Cypridina Luciferin in the Presence of Human Plasma Alpha 1-Acid Glycoprotein International Journal of Molecular Sciences doi: 10.3390/ijms21207516 Authors: Shusei Kanie Mami Komatsu Yasuo Mitani The enzyme Cypridina luciferase (CLase) enables Cypridina luciferin to emit light efficiently through an oxidation reaction. The catalytic mechanism on the substrate of CLase has been studied, but the details remain to be clarified. Here, we examined...
IJMS, Vol. 21, Pages 7518: RNAi-Mediated Knockdown of Transcription Factor E93 in Nymphs of the Desert Locust (Schistocerca gregaria) Inhibits Adult Morphogenesis and Results in Supernumerary Juvenile Stages International Journal of Molecular Sciences doi: 10.3390/ijms21207518 Authors: Marijke Gijbels Elisabeth Marchal Thomas Wolf Verdonckt Evert Bruyninckx Jozef Vanden Broeck Postembryonic development of insects is coordinated by juvenile hormone (JH) together with ecdysteroids....
IJMS, Vol. 21, Pages 7511: All-Atomic Molecular Dynamic Studies of Human and Drosophila CDK8: Insights into Their Kinase Domains, the LXXLL Motifs, and Drug Binding Site International Journal of Molecular Sciences doi: 10.3390/ijms21207511 Authors: Wu Xu Xiao-Jun Xie Ali K. Faust Mengmeng Liu Xiao Li Feng Chen Ashlin A. Naquin Avery C. Walton Peter W. Kishbaugh Jun-Yuan Ji Cyclin-dependent kinase 8 (CDK8) and its regulatory partner Cyclin C (CycC) play conserved...
IJMS, Vol. 21, Pages 7515: Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases International Journal of Molecular Sciences doi: 10.3390/ijms21207515 Authors: Chih-Hsuan Lai Co-Chih Chang Huai-Chia Chuang Tse-Hua Tan Ping-Chiang Lyu Cysteine-based protein tyrosine phosphatases (Cys-based PTPs) perform dephosphorylation to regulate signaling pathways in cellular responses. The hydrogen bonding network in their active...
IJMS, Vol. 21, Pages 7502: Chiral Cyclobutane-Containing Cell-Penetrating Peptides as Selective Vectors for Anti-Leishmania Drug Delivery Systems International Journal of Molecular Sciences doi: 10.3390/ijms21207502 Authors: Ona Illa José-Antonio Olivares Nerea Gaztelumendi Laura Martínez-Castro Jimena Ospina María-Ángeles Abengozar Giuseppe Sciortino Jean-Didier Maréchal Carme Nogués Míriam Royo Luis Rivas Rosa M. Ortuño Two series of new hybrid γ/γ-peptides,...
IJMS, Vol. 21, Pages 7503: Development of a Protein Scaffold for Arginine Sensing Generated through the Dissection of the Arginine-Binding Protein from Thermotoga maritima International Journal of Molecular Sciences doi: 10.3390/ijms21207503 Authors: Giovanni Smaldone Alessia Ruggiero Nicole Balasco Luigi Vitagliano Arginine is one of the most important nutrients of living organisms as it plays a major role in important biological pathways. However, the accumulation of arginine...
IJMS, Vol. 21, Pages 7513: Functions of Osteocalcin in Bone, Pancreas, Testis, and Muscle International Journal of Molecular Sciences doi: 10.3390/ijms21207513 Authors: Toshihisa Komori Osteocalcin (Ocn), which is specifically produced by osteoblasts, and is the most abundant non-collagenous protein in bone, was demonstrated to inhibit bone formation and function as a hormone, which regulates glucose metabolism in the pancreas, testosterone synthesis in the testis, and muscle mass, based...
IJMS, Vol. 21, Pages 7512: Multi-Omics Strategies for Decoding Smoke-Assisted Germination Pathways and Seed Vigour International Journal of Molecular Sciences doi: 10.3390/ijms21207512 Authors: Utpal Bose Angéla Juhász James A. Broadbent Setsuko Komatsu Michelle L. Colgrave The success of seed germination and the successful establishment of seedlings across diverse environmental conditions depends on seed vigour, which is of both economic and ecologic importance. The smoke-derived...
IJMS, Vol. 21, Pages 7514: Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy International Journal of Molecular Sciences doi: 10.3390/ijms21207514 Authors: Philipp Steven Sebastian Schwab Anne Kiesewetter Daniel R. Saban Michael E. Stern Uta Gehlsen Conjunctiva-associated tissue (CALT) is assumed to play a crucial role in the immune system of the ocular surface. Its function in several ocular...
IJMS, Vol. 21, Pages 7509: Long-Chain Saturated Fatty Acids, Palmitic and Stearic Acids, Enhance the Repair of Photosystem II International Journal of Molecular Sciences doi: 10.3390/ijms21207509 Authors: Haruhiko Jimbo Kensuke Takagi Takashi Hirashima Yoshitaka Nishiyama Hajime Wada Free fatty acids (FFA) generated in cyanobacterial cells can be utilized for the biodiesel that is required for our sustainable future. The combination of FFA and strong light induces severe...
IJMS, Vol. 21, Pages 7510: Pannexin-1 Deficiency Decreases Epileptic Activity in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21207510 Authors: Mark S. Aquilino Paige Whyte-Fagundes Mark K. Lukewich Liang Zhang Berj L. Bardakjian Georg R. Zoidl Peter L. Carlen Objective: Pannexin-1 (Panx1) is suspected of having a critical role in modulating neuronal excitability and acute neurological insults. Herein, we assess the changes in behavioral and electrophysiological...
IJMS, Vol. 21, Pages 7508: m6A RNA Methylation in Marine Plants: First Insights and Relevance for Biological Rhythms International Journal of Molecular Sciences doi: 10.3390/ijms21207508 Authors: Miriam Ruocco Luca Ambrosino Marlene Jahnke Maria Luisa Chiusano Isabel Barrote Gabriele Procaccini João Silva Emanuela Dattolo Circadian regulations are essential for enabling organisms to synchronize physiology with environmental light-dark cycles. Post-transcriptional...
IJMS, Vol. 21, Pages 7505: Clinical Application of Oncolytic Viruses: A Systematic Review International Journal of Molecular Sciences doi: 10.3390/ijms21207505 Authors: Mary Cook Aman Chauhan Leveraging the immune system to thwart cancer is not a novel strategy and has been explored via cancer vaccines and use of immunomodulators like interferons. However, it was not until the introduction of immune checkpoint inhibitors that we realized the true potential of immunotherapy in combating...
IJMS, Vol. 21, Pages 7507: Platelet Induced Functional Alteration of CD4+ and CD8+ T Cells in HNSCC International Journal of Molecular Sciences doi: 10.3390/ijms21207507 Authors: Christina Polasky Franziska Wendt Ralph Pries Barbara Wollenberg Platelets (PLT) are the second most abundant cell type in human blood and exert various immune-regulatory functions under both physiological and pathological conditions. In fact, immune cell regulation via platelets has been demonstrated...
IJMS, Vol. 21, Pages 7504: DNA Damage Response and Immune Defense International Journal of Molecular Sciences doi: 10.3390/ijms21207504 Authors: Claudia Nastasi Laura Mannarino Maurizio D’Incalci DNA damage is the cause of numerous human pathologies including cancer, premature aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn, coordinates DNA damage checkpoint activation and promotes the removal of DNA lesions. In recent years, several studies have...
IJMS, Vol. 21, Pages 7501: How Machine Learning Methods Helped Find Putative Rye Wax Genes Among GBS Data International Journal of Molecular Sciences doi: 10.3390/ijms21207501 Authors: Magdalena Góralska Jan Bińkowski Natalia Lenarczyk Anna Bienias Agnieszka Grądzielewska Ilona Czyczyło-Mysza Kamila Kapłoniak Stefan Stojałowski Beata Myśków The standard approach to genetic mapping was supplemented by machine learning (ML) to establish the location of the rye gene...
IJMS, Vol. 21, Pages 7499: Cytosolic TaGAPC2 Enhances Tolerance to Drought Stress in Transgenic Arabidopsis Plants International Journal of Molecular Sciences doi: 10.3390/ijms21207499 Authors: Lin Zhang Hanwen Zhang Shushen Yang Drought is a major natural disaster that seriously affects agricultural production, especially for winter wheat in boreal China. As functional proteins, the functions and mechanisms of glyceraldehyde-3-phosphate dehydrogenase in cytoplasm (GAPCs) have...
IJMS, Vol. 21, Pages 7500: Sequenced Combinations of Cisplatin and Selected Phytochemicals towards Overcoming Drug Resistance in Ovarian Tumour Models International Journal of Molecular Sciences doi: 10.3390/ijms21207500 Authors: Safiah Ibrahim Althurwi Jun Q. Yu Philip Beale Fazlul Huq In the present study, cisplatin, artemisinin, and oleanolic acid were evaluated alone, and in combination, on human ovarian A2780, A2780ZD0473R, and A2780cisR cancer cell lines, with the aim...
IJMS, Vol. 21, Pages 7498: Solid-Phase Synthesis and In-Silico Analysis of Iron-Binding Catecholato Chelators International Journal of Molecular Sciences doi: 10.3390/ijms21207498 Authors: Ranko Gacesa Andrea A. P. Tripodi Agostino Cilibrizzi Antonella Leggio Robert Hider Vincenzo Abbate Siderophores are iron-complexing compounds synthesized by bacteria and fungi. They are low molecular weight compounds (500-1500 Daltons) possessing high affinity for iron(III). Since 1970...
IJMS, Vol. 21, Pages 7496: Toward Drug-Like Multispecific Antibodies by Design International Journal of Molecular Sciences doi: 10.3390/ijms21207496 Authors: Manali S. Sawant Craig N. Streu Lina Wu Peter M. Tessier The success of antibody therapeutics is strongly influenced by their multifunctional nature that couples antigen recognition mediated by their variable regions with effector functions and half-life extension mediated by a subset of their constant regions. Nevertheless,...
IJMS, Vol. 21, Pages 7497: Review: Proteomic Techniques for the Development of Flood-Tolerant Soybean International Journal of Molecular Sciences doi: 10.3390/ijms21207497 Authors: Xin Wang Setsuko Komatsu Soybean, which is rich in protein and oil as well as phytochemicals, is cultivated in several climatic zones. However, its growth is markedly decreased by flooding stress, which is caused by climate change. Proteomic techniques were used for understanding the flood-response and...
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JCDD, Vol. 7, Pages 43: A Rare Presentation of Common Arterial Trunk with Intact Ventricular Septum Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7040043 Authors: Diane E. Spicer Thora S. Steffensen Common arterial trunk is a rare anomaly on its own, but with an intact ventricular septum it is extremely rare. An unexpected finding at autopsy prompted a review of the literature and a review of the developmental considerations associated with the outflow tracts....
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JCM, Vol. 9, Pages 3273: Ten-Year in-Hospital Mortality Trends among Paediatric Injured Patients in Japan: A Nationwide Observational Study Journal of Clinical Medicine doi: 10.3390/jcm9103273 Authors: Chiaki Toida Takashi Muguruma Masayasu Gakumazawa Mafumi Shinohara Takeru Abe Ichiro Takeuchi Naoto Morimura Injury is a major cause of worldwide child mortality. This retrospective nationwide study aimed to evaluate the characteristics of paediatric injured patients...
JCM, Vol. 9, Pages 3271: Clinical Behavior of Short Dental Implants: Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9103271 Authors: Andrea Torres-Alemany Lucía Fernández-Estevan Rubén Agustín-Panadero José María Montiel-Company Carlos Labaig-Rueda José Félix Mañes-Ferrer Short implants are an increasingly common alternative to other surgical techniques in areas where bone availability is reduced. Despite the advantages they offer, a variety...
JCM, Vol. 9, Pages 3272: Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9103272 Authors: Callaghan Cai McCafferty Van Den Helm Horton MacLaren Monagle Ignjatovic The accumulation of blood proteins and cells on extracorporeal membrane oxygenation (ECMO) circuits has been proposed as a contributing factor to the coagulopathic state of many patients....
JCM, Vol. 9, Pages 3269: Cardiovascular Events throughout the Disease Course in Chronic Myeloid Leukaemia Patients Treated with Tyrosine Kinase Inhibitors—A Single-Centre Retrospective Study Journal of Clinical Medicine doi: 10.3390/jcm9103269 Authors: Varga Tilea Petra Tilinca Gliga Demian Introduction. Cardiovascular risk factors, pre-existing comorbidities, molecular factors, and the direct effects of second- and third-generation BCR-ABL1 tyrosine kinase inhibitors...
JCM, Vol. 9, Pages 3263: Redefining the Prognostic Value of High-Sensitivity Troponin in COVID-19 Patients: The Importance of Concomitant Coronary Artery Disease Journal of Clinical Medicine doi: 10.3390/jcm9103263 Authors: Schiavone Gasperetti Mancone Kaplan Gobbi Mascioli Busana Saguner Mitacchione Giacomelli Sardella Viecca Duru Antinori Carugo Bartorelli Tondo Galli Fedele Forleo Background: Although studies...
JCM, Vol. 9, Pages 3267: Complexity of TNF-α Signaling in Heart Disease Journal of Clinical Medicine doi: 10.3390/jcm9103267 Authors: Filip Rolski Przemysław Błyszczuk Heart disease is a leading cause of death with unmet clinical needs for targeted treatment options. Tumor necrosis factor alpha (TNF-α) represents a master pro-inflammatory cytokine that plays an important role in many immunopathogenic processes. Anti-TNF-α therapy is widely used in treating autoimmune...
JCM, Vol. 9, Pages 3266: HbA1c and Aortic Calcification Index as Noninvasive Predictors of Pre-Existing Histopathological Damages in Living Donor Kidney Transplantation Journal of Clinical Medicine doi: 10.3390/jcm9103266 Authors: Kosuke Tanaka Shigeyoshi Yamanaga Yuji Hidaka Sho Nishida Kohei Kinoshita Akari Kaba Toshinori Ishizuka Satoshi Hamanoue Kenji Okumura Chiaki Kawabata Mariko Toyoda Asami Takeda Akira Miyata Masayuki Kashima Hiroshi Yokomizo...
JCM, Vol. 9, Pages 3268: Prognostic Significance of Tumor Location in T2 Gallbladder Cancer: A Korea Tumor Registry System Biliary Pancreas (KOTUS-BP) Database Analysis Journal of Clinical Medicine doi: 10.3390/jcm9103268 Authors: Lee Choi Kim Heo Jeong Lee Seo Yoon Jang Background: T2 gallbladder cancer (GBC) is subdivided into T2a and T2b by the American Joint Committee on Cancer (AJCC) 8th edition. However; there is a lack of evidence for the prognostic...
JCM, Vol. 9, Pages 3265: Prevalence of Lower Extremity Arterial Disease as Measured by Low Ankle-Brachial Index in Patients with Acute Cerebral Ischemic Events Journal of Clinical Medicine doi: 10.3390/jcm9103265 Authors: Magdalena Konieczna-Brazis Paweł Sokal Paweł Brazis Tomasz Grzela Milena Świtońska Violetta Palacz-Duda Background: Low ankle–brachial index (ABI) of ≤0.9 is diagnostic of lower extremity arterial disease (LEAD). It is also a strong marker...
JCM, Vol. 9, Pages 3264: Sirolimus Prolongs Survival after Living Donor Liver Transplantation for Hepatocellular Carcinoma Beyond Milan Criteria: A Prospective, Randomised, Open-Label, Multicentre Phase 2 Trial Journal of Clinical Medicine doi: 10.3390/jcm9103264 Authors: Kwang-Woong Lee Seong Hoon Kim Kyung Chul Yoon Jeong-Moo Lee Jae-Hyung Cho Suk Kyun Hong Nam-Joon Yi Sung-Sik Han Sang-Jae Park Kyung-Suk Suh Sirolimus (SRL) has been reported to benefit patients...
JCM, Vol. 9, Pages 3260: A Decade of Progress in Deep Brain Stimulation of the Subcallosal Cingulate for the Treatment of Depression Journal of Clinical Medicine doi: 10.3390/jcm9103260 Authors: Sharafuddin Khairuddin Fung Yin Ngo Wei Ling Lim Luca Aquili Naveed Ahmed Khan Man-Lung Fung Ying-Shing Chan Yasin Temel Lee Wei Lim Major depression contributes significantly to the global disability burden. Since the first clinical study of deep brain stimulation (DBS),...
JCM, Vol. 9, Pages 3270: Decrease of Quality of Life, Functional Assessment and Associated Psychological Distress in Patients with Hypoallergenic Total Knee Arthroplasty Journal of Clinical Medicine doi: 10.3390/jcm9103270 Authors: Peña Ortega Buján De la Torre Total knee arthroplasty (TKA) is the final treatment for knee osteoarthritis, and 15–30% of patients show little or no improvement. This high percentage is related to aspects of the surgical technique, the...
JCM, Vol. 9, Pages 3261: Skin Manifestations in COVID-19: Prevalence and Relationship with Disease Severity Journal of Clinical Medicine doi: 10.3390/jcm9103261 Authors: Priscila Giavedoni Sebastián Podlipnik Juan M. Pericàs Irene Fuertes de Vega Adriana García-Herrera Llúcia Alós Cristina Carrera Cristina Andreu-Febrer Judit Sanz-Beltran Constanza Riquelme-Mc Loughlin Josep Riera-Monroig Andrea Combalia Xavier Bosch-Amate Daniel Morgado-Carrasco Ramon...
JCM, Vol. 9, Pages 3258: A Predictive Study of Resilience and Its Relationship with Academic and Work Dimensions during the COVID-19 Pandemic Journal of Clinical Medicine doi: 10.3390/jcm9103258 Authors: Silvia San Román-Mata Félix Zurita-Ortega Pilar Puertas-Molero Georgian Badicu Gabriel González-Valero Background: The aim of the present study was to describe the resilience levels in a Spanish population during the Coronavirus (COVID-19) pandemic and to analyze the existing...
JCM, Vol. 9, Pages 3262: Defining Pre-Clinical Psoriatic Arthritis in an Integrated Dermato-Rheumatology Environment Journal of Clinical Medicine doi: 10.3390/jcm9103262 Authors: Savage Tinazzi Zabotti Laws Wittmann McGonagle In excess of three quarters of patients with psoriatic arthritis (PsA) have preceding psoriasis (PsO), which offers a clinical biomarker for the recognition of early PsA. Numerous surveys have shown a remarkably high frequency of clinically...
JCM, Vol. 9, Pages 3259: Characteristics and Prognosis of COVID-19 in Patients with COPD Journal of Clinical Medicine doi: 10.3390/jcm9103259 Authors: Graziani Soriano Del Rio-Bermudez Morena Díaz Castillo Alonso Ancochea Lumbreras Izquierdo Patients with Chronic Obstructive Pulmonary Disease (COPD) have a higher prevalence of coronary ischemia and other factors that put them at risk for COVID-19-related complications. We aimed to explore the impact...
JCM, Vol. 9, Pages 3255: Physiotherapy for Prevention and Treatment of Fecal Incontinence in Women—Systematic Review of Methods Journal of Clinical Medicine doi: 10.3390/jcm9103255 Authors: Agnieszka Irena Mazur-Bialy Daria Kołomańska-Bogucka Marcin Opławski Sabina Tim Fecal incontinence (FI) affects approximately 0.25–6% of the population, both men and women. The most common causes of FI are damage to/weakness of the anal sphincter muscle and/or pelvic floor muscles,...
JCM, Vol. 9, Pages 3256: The Influence of Gestational Diabetes Mellitus upon the Selected Parameters of the Maternal and Fetal System of Insulin-Like Growth Factors (IGF-1, IGF-2, IGFBP1-3)—A Review and a Clinical Study Journal of Clinical Medicine doi: 10.3390/jcm9103256 Authors: Tomasz Gęca Anna Kwaśniewska Background: Gestational diabetes mellitus (GDM), defined as impaired glucose tolerance with onset or first recognition in pregnancy, increases the risk of not only maternal but...
JCM, Vol. 9, Pages 3257: An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations Journal of Clinical Medicine doi: 10.3390/jcm9103257 Authors: Hartmut Schneider Martin Ahrens Michaela Strumpski Claudia Rüger Matthias Häfer Gereon Hüttmann Dirk Theisen-Kunde Hinnerk Schulz-Hildebrandt Rainer Haak Caries, the world’s most common chronic disease, remains a major cause of invasive restorative dental treatment....
JCM, Vol. 9, Pages 3254: Computer-Aided Rehabilitation Supported by Zygomatic Implants: A Cohort Study Comparing Atrophic with Oncologic Patients after Five Years of Follow-Up Journal of Clinical Medicine doi: 10.3390/jcm9103254 Authors: Gerardo Pellegrino Francesco Basile Daniela Relics Agnese Ferri Francesco Grande Achille Tarsitano Claudio Marchetti The aim of this study was to evaluate the survival and clinical success rate, complications, and patients’...
JCM, Vol. 9, Pages 3252: The Role of Positive Psychological Factors in the Association between Pain Intensity and Pain Interference in Individuals with Chronic Musculoskeletal Pain: A Cross-Sectional Study Journal of Clinical Medicine doi: 10.3390/jcm9103252 Authors: Javier Martinez-Calderon Mar Flores-Cortes Susana Clavero-Cano Jose Miguel Morales-Asencio Mark P. Jensen Antonio Rondon-Ramos Juan Luis Diaz-Cerrillo Gina Rocío Ariza-Hurtado Alejandro Luque-Suarez ...
JCM, Vol. 9, Pages 3253: Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review) Journal of Clinical Medicine doi: 10.3390/jcm9103253 Authors: Fisher Fisher Smith Osteoporosis (OP) and osteoporotic fractures (OFs) are common multifactorial and heterogenic disorders of increasing incidence. Helicobacter pylori (H.p.) colonizes the stomach approximately in half of the world’s population, causes gastroduodenal diseases and is prevalent in numerous...
JCM, Vol. 9, Pages 3251: Prognostic Factor Analysis of Visual Outcome after Vitrectomy for Rhegmatogenous Retinal Detachment Journal of Clinical Medicine doi: 10.3390/jcm9103251 Authors: Polona Zaletel Benda Bor Vratanar Goran Petrovski Ana Uršula Gavrić Katja Matović Ana Gornik Katarina Vergot Anila Lumi Xhevat Lumi Pars plana vitrectomy (PPV) is a surgical approach mainly chosen for complex rhegmatogenous retinal detachment (RRD) repair with highly variable...
JCM, Vol. 9, Pages 3250: Temporomandibular Disorders and Bruxism Outbreak as a Possible Factor of Orofacial Pain Worsening during the COVID-19 Pandemic—Concomitant Research in Two Countries Journal of Clinical Medicine doi: 10.3390/jcm9103250 Authors: Alona Emodi-Perlman Ilana Eli Joanna Smardz Nir Uziel Gniewko Wieckiewicz Efrat Gilon Natalia Grychowska Mieszko Wieckiewicz Background: In late December 2019, a new pandemic caused by the SARS-CoV-2 (Severe Acute Respiratory...
Σήμανση της παραπάνω ενότητας ως αναγνωσμένης
JFB, Vol. 11, Pages 74: Injectable Enzymatically Hardened Calcium Phosphate Biocement Journal of Functional Biomaterials doi: 10.3390/jfb11040074 Authors: Medvecky Štulajterová Giretova Luptakova Sopčák (1) Background: The preparation and characterization of novel fully injectable enzymatically hardened tetracalcium phosphate/monetite cements (CXI cements) using phytic acid/phytase (PHYT/F3P) hardening liquid with a small addition of polyacrylic acid/carboxymethyl cellulose...
Σήμανση της παραπάνω ενότητας ως αναγνωσμένης
JoF, Vol. 6, Pages 221: The “Little Iron Waltz”: The Ternary Response of Paracoccidioides spp. to Iron Deprivation Journal of Fungi doi: 10.3390/jof6040221 Authors: Aparecido Ferreira de Souza Marcella Silva de Paula Raisa Melo Lima Marielle Garcia Silva Juliana Santana de Curcio Maristela Pereira Célia Maria de Almeida Soares Paracoccidioides is a genus of thermodimorphic fungi that causes paracoccidioidomycosis. When in the host, the fungus undergoes several challenges,...
JoF, Vol. 6, Pages 220: Molecular and Biological Properties of Snakins: The Foremost Cysteine-Rich Plant Host Defense Peptides Journal of Fungi doi: 10.3390/jof6040220 Authors: Tao Su Mei Han Dan Cao Mingyue Xu Plant host defense peptides (HDPs), also known as antimicrobial peptides (AMPs), are regarded as one of the most prevalent barriers elaborated by plants to combat various infective agents. Among the multiple classes of HDPs, the Snakin class attracts special concern,...
JoF, Vol. 6, Pages 219: Isolation of Beauveria bassiana from the Chagas Disease Vector Triatoma infestans in the Gran Chaco Region of Argentina: Assessment of Gene Expression during Host–Pathogen Interaction Journal of Fungi doi: 10.3390/jof6040219 Authors: Linda Vanesa Baldiviezo Nicolás Pedrini Marianela Santana María Constanza Mannino Lucía Beatriz Nieva Alberto Gentile Rubén Marino Cardozo A native strain of the entomopathogenic fungus Beauveria bassiana (Bb-C001)...
JoF, Vol. 6, Pages 218: Novel Colloidal Nanocarrier of Cetylpyridinium Chloride: Antifungal Activities on Candida Species and Cytotoxic Potential on Murine Fibroblasts Journal of Fungi doi: 10.3390/jof6040218 Authors: Heitor Ceolin Araujo Laís Salomão Arias Anne Caroline Morais Caldeirão Lanay Caroline de Freitas Assumpção Marcela Grigoletto Morceli Francisco Nunes de Souza Neto Emerson Rodrigues de Camargo Sandra Helena Penha Oliveira Juliano Pelim Pessan Douglas...
Σήμανση της παραπάνω ενότητας ως αναγνωσμένης
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