IJERPH, Vol. 17, Pages 6318: The Principal at Risk: Stress and Organizing Mindfulness in the School Context International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17176318 Authors: Pierluigi Diotaiuti Stefania Mancone Fernando Bellizzi Giuseppe Valente Background: In recent years the role of school principals is becoming increasingly complex and responsible. Methods: This study was voluntarily attended by 419 Italian school principals who were administered...
Mon Aug 31, 2020 03:00
IJERPH, Vol. 17, Pages 6317: Evaluating the Social Marketing Success Criteria in Health Promotion: A F-DEMATEL Approach International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17176317 Authors: Chi-Horng Liao Health promotion campaigns are used to raise awareness about health issues with the purpose of improving health outcomes and community wellbeing. They are important for increasing community awareness of health behavior changes. In the application of...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6335: The Effect of Dysfunctional Ubiquitin Enzymes in the Pathogenesis of Most Common Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21176335 Authors: Gizem Celebi Hale Kesim Ebru Ozer Ozlem Kutlu Ubiquitination is a multi-step enzymatic process that involves the marking of a substrate protein by bonding a ubiquitin and protein for proteolytic degradation mainly via the ubiquitin–proteasome system (UPS). The process is regulated...
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IJMS, Vol. 21, Pages 6334: Genetic and Epigenetic Mechanisms Underlying Vascular Smooth Muscle Cell Phenotypic Modulation in Abdominal Aortic Aneurysm International Journal of Molecular Sciences doi: 10.3390/ijms21176334 Authors: Rijan Gurung Andrew Mark Choong Chin Cheng Woo Roger Foo Vitaly Sorokin Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6323: Aryl Hydrocarbon Receptor Signaling Is Functional in Immune Cells of Rainbow Trout (Oncorhynchus mykiss) International Journal of Molecular Sciences doi: 10.3390/ijms21176323 Authors: Jun-Young Song Ayako Casanova-Nakayama Anja-Maria Möller Shin-Ichi Kitamura Kei Nakayama Helmut Segner The arylhydrocarbon receptor (AhR) is an important signaling pathway in the immune system of mammals. In addition to its physiological functions, the receptor...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6333: Novel Missense CACNA1G Mutations Associated with Infantile-Onset Developmental and Epileptic Encephalopathy International Journal of Molecular Sciences doi: 10.3390/ijms21176333 Authors: Géza Berecki Katherine L. Helbig Tyson L. Ware Bronwyn Grinton Cara M. Skraban Eric D. Marsh Samuel F. Berkovic Steven Petrou The CACNA1G gene encodes the low-voltage-activated Cav3.1 channel, which is expressed in various areas of the CNS, including the...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6331: Effects of Early Life Stress on Epigenetic Changes of the Glucocorticoid Receptor 17 Promoter during Adulthood International Journal of Molecular Sciences doi: 10.3390/ijms21176331 Authors: Mi Kyoung Seo Seon-gu Kim Dae-Hyun Seog Won-Myong Bahk Seong-Ho Kim Sung Woo Park Jung Goo Lee Growing evidence suggests that early life stress (ELS) has long-lasting effects on glucocorticoid receptor (GR) expression and behavior via epigenetic changes...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6332: Quantification of Iron Release from Native Ferritin and Magnetoferritin Induced by Vitamins B2 and C International Journal of Molecular Sciences doi: 10.3390/ijms21176332 Authors: Strbak Balejcikova Kmetova Gombos Trancikova Pokusa Kopcansky Various pathological processes in humans are associated with biogenic iron accumulation and the mineralization of iron oxide nanoparticles, especially magnetite. Ferritin has been proposed as a...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6330: Identification of CD34+/PGDFRα+ Valve Interstitial Cells (VICs) in Human Aortic Valves: Association of Their Abundance, Morphology and Spatial Organization with Early Calcific Remodeling International Journal of Molecular Sciences doi: 10.3390/ijms21176330 Authors: Lis Dubrowski Lis Solewski Witkowska Aleksandrovych Jasek-Gajda Hołda Gil Litwin Aortic valve interstitial cells (VICs) constitute a heterogeneous population...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6329: Targeted Therapies in Early Stage NSCLC: Hype or Hope? International Journal of Molecular Sciences doi: 10.3390/ijms21176329 Authors: Alex Friedlaender Alfredo Addeo Alessandro Russo Vanesa Gregorc Diego Cortinovis Christian D. Rolfo Non-small-cell lung cancer (NSCLC) represents roughly 85% of lung cancers, with an incidence that increases yearly across the world. The introduction in clinical practice of several new and more effective molecules...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6328: The Role of Macrophages in Vascular Repair and Regeneration after Ischemic Injury International Journal of Molecular Sciences doi: 10.3390/ijms21176328 Authors: Huiling Hong Xiao Yu Tian Macrophage is one of the important players in immune response which perform many different functions during tissue injury, repair, and regeneration. Studies using animal models of cardiovascular diseases have provided a clear picture describing the effect of macrophages...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6327: The Development of Hyaluronan/Fucoidan-Based Nanoparticles as Macrophages Targeting an Epigallocatechin-3-Gallate Delivery System International Journal of Molecular Sciences doi: 10.3390/ijms21176327 Authors: Chang-Hsun Ho Pei-Yi Chu Shin-Lei Peng Shun-Chih Huang Yu-Hsin Lin The aim of this study was to develop a macrophage-targeted nanoparticle composed of hyaluronan/fucoidan complexes with polyethylene glycol-gelatin to encapsulate and deliver...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6324: Evolution of Escherichia coli Expression System in Producing Antibody Recombinant Fragments International Journal of Molecular Sciences doi: 10.3390/ijms21176324 Authors: Annamaria Sandomenico Jwala P. Sivaccumar Menotti Ruvo Antibodies and antibody-derived molecules are continuously developed as both therapeutic agents and key reagents for advanced diagnostic investigations. Their application in these fields has indeed greatly expanded the demand of...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6326: Antibiotic-Resistant and Non-Resistant Bacteria Display Similar Susceptibility to Dielectric Barrier Discharge Plasma International Journal of Molecular Sciences doi: 10.3390/ijms21176326 Authors: Akikazu Sakudo Tatsuya Misawa Here, we examined whether antibiotic-resistant and non-resistant bacteria show a differential susceptibility to plasma treatment. Escherichia coli DH5α were transformed with pPRO-EX-HT-CAT, which encodes an ampicillin resistance...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6325: Analysis of Membrane Transport Equations for Reverse Electrodialysis (RED) Using Irreversible Thermodynamics International Journal of Molecular Sciences doi: 10.3390/ijms21176325 Authors: Wojciech Kujawski Andriy Yaroshchuk Emiliy Zholkovskiy Izabela Koter Stanislaw Koter Reverse electrodialysis (RED) is an electro-membrane process for the conversion of mixing energy into electricity. One important problem researchers' face when modeling the RED...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6319: Myeloid Cell Modulation by Tumor-Derived Extracellular Vesicles International Journal of Molecular Sciences doi: 10.3390/ijms21176319 Authors: Arkhypov Lasser Petrova Weber Groth Utikal Altevogt Umansky Extracellular vesicles (EV) can carry proteins, RNA and DNA, thus serving as communication tools between cells. Tumor cells secrete EV, which can be taken up by surrounding cells in the tumor microenvironment as well as by cells...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6318: Exploiting Manipulated Small Extracellular Vesicles to Subvert Immunosuppression at the Tumor Microenvironment Through Mannose Receptor/CD206 Targeting International Journal of Molecular Sciences doi: 10.3390/ijms21176318 Authors: Fiani Barreca Sargiacomo Ferrantelli Manfredi Federico Immunosuppression at tumor microenvironment (TME) is one of the major obstacles to be overcome for an effective therapeutic intervention against solid tumors....
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6317: Decellularized Extracellular Matrices and Cardiac Differentiation: Study on Human Amniotic Fluid-Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21176317 Authors: Gaggi Di Credico Izzicupo Sancilio Di Mauro Iannetti Dolci Amabile Di Baldassarre Ghinassi Cell therapy with a variety of stem populations is increasingly being investigated as a promising regenerative strategy for cardiovascular (CV) diseases....
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6300: Deoxynivalenol Exposure Suppresses Adipogenesis by Inhibiting the Expression of Peroxisome Proliferator-Activated Receptor Gamma 2 (PPARγ2) in 3T3-L1 Cells International Journal of Molecular Sciences doi: 10.3390/ijms21176300 Authors: Yurong Zhao Shulin Tang Ruqin Lin Ting Zheng Danyang Li Xiaoxuan Chen Jiahui Zhu Jikai Wen Yiqun Deng Deoxynivalenol (DON)—a type B trichothecene mycotoxin, mainly produced by the secondary metabolism...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6322: The Lysine Specific Demethylase-1 Negatively Regulates the COL9A1 Gene in Human Articular Chondrocytes International Journal of Molecular Sciences doi: 10.3390/ijms21176322 Authors: Durand Dufour Aubert-Foucher Oger-Desfeux Pasdeloup Lustig Servien Vaz Perrier-Groult Mallein-Gerin Lafont Osteoarthritis (OA) is a degenerative disease of the joints which is associated with an impaired production of the cartilage matrix...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6320: Established and Emerging Mechanisms in the Pathogenesis of Arrhythmogenic Cardiomyopathy: A Multifaceted Disease International Journal of Molecular Sciences doi: 10.3390/ijms21176320 Authors: Gao Puthenvedu Lombardi Chen Arrhythmogenic cardiomyopathy (ACM) is a heritable myocardial disease that manifests with cardiac arrhythmias, syncope, sudden cardiac death, and heart failure in the advanced stages. The pathological hallmark of ACM is a gradual...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6306: Repurposing Quinacrine for Treatment of Malignant Mesothelioma: In-Vitro Therapeutic and Mechanistic Evaluation International Journal of Molecular Sciences doi: 10.3390/ijms21176306 Authors: Nishant S. Kulkarni Bhuvaneshwar Vaidya Vineela Parvathaneni Debarati Bhanja Vivek Gupta Malignant mesothelioma (MM) is a rare type of cancer primarily affecting mesothelial cells lining the pleural cavity. In this study, we propose to repurpose quinacrine (QA),...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6305: Interactions of Zinc Oxide Nanostructures with Mammalian Cells: Cytotoxicity and Photocatalytic Toxicity International Journal of Molecular Sciences doi: 10.3390/ijms21176305 Authors: Chengzhu Liao Yuming Jin Yuchao Li Sie Chin Tjong This article presents a state-of-the-art review and analysis of literature studies on the morphological structure, fabrication, cytotoxicity, and photocatalytic toxicity of zinc oxide nanostructures (nZnO) of mammalian...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6309: Complement C4 Gene Copy Number Variation Genotyping by High Resolution Melting PCR International Journal of Molecular Sciences doi: 10.3390/ijms21176309 Authors: Claudia P. Jaimes-Bernal Monte Trujillo Francisco José Márquez Antonio Caruz Background: Complement C4 gene copy number variation plays an important role as a determinant of genetic susceptibility to common diseases, such as systemic lupus erythematosus, schizophrenia, rheumatoid arthritis,...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6321: Emerging Roles of the Selective Autophagy in Plant Immunity and Stress Tolerance International Journal of Molecular Sciences doi: 10.3390/ijms21176321 Authors: Ran Hashimi Liu Autophagy is a conserved recycling system required for cellular homeostasis. Identifications of diverse selective receptors/adaptors that recruit appropriate autophagic cargoes have revealed critical roles of selective autophagy in different biological processes in plants. In...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6315: The Penta-EF-Hand ALG-2 Protein Interacts with the Cytosolic Domain of the SOCE Regulator SARAF and Interferes with Ubiquitination International Journal of Molecular Sciences doi: 10.3390/ijms21176315 Authors: Wei Zhang Ayaka Muramatsu Rina Matsuo Naoki Teranishi Yui Kahara Terunao Takahara Hideki Shibata Masatoshi Maki ALG-2 is a penta-EF-hand Ca2+-binding protein and interacts with a variety of proteins in mammalian cells. In order to...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6314: Targeting Adaptive IRE1a Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib International Journal of Molecular Sciences doi: 10.3390/ijms21176314 Authors: Yusuke Yamashita Shuhei Morita Hiroki Hosoi Hiroshi Kobata Shohei Kishimoto Tatsuya Ishibashi Hiroyuki Mishima Akira Kinoshita Bradley J. Backes Koh-Ichiro Yoshiura Feroz R. Papa Takashi Sonoki Shinobu Tamura Background: Inositol-requiring...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6316: Encapsulation of Adipose-Derived Mesenchymal Stem Cells in Calcium Alginate Maintains Clonogenicity and Enhances their Secretory Profile International Journal of Molecular Sciences doi: 10.3390/ijms21176316 Authors: Lucille Capin Nacira Abbassi Maëlle Lachat Marie Calteau Cynthia Barratier Ali Mojallal Sandrine Bourgeois Céline Auxenfans Adipose-derived mesenchymal stem cells (ASCs) are well known for their secretory potential, which confers...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6312: Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21176312 Authors: Alazne Arrazola Sastre Miriam Luque Montoro Patricia Gálvez-Martín Hadriano M Lacerda Alejandro M. Lucia Francisco Llavero José Luis Zugaza Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators of many key cellular events such as...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6299: Nitrogen Regulating the Expression and Localization of Four Glutamine Synthetase Isoforms in Wheat (Triticum aestivum L.) International Journal of Molecular Sciences doi: 10.3390/ijms21176299 Authors: Yihao Wei Xiaochun Wang Zhiyong Zhang Shuping Xiong Xiaodan Meng Jie Zhang Lulu Wang Xiaojiao Zhang Meiqin Yu Xinming Ma Glutamine synthetase (GS), the key enzyme in plant nitrogen assimilation, is strictly regulated at multiple levels,...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6313: GPx8 Expression in Rat Oocytes, Embryos, and Female Genital Organs During Preimplantation Period of Pregnancy International Journal of Molecular Sciences doi: 10.3390/ijms21176313 Authors: Jozef Mihalik Andrea Kreheľová Veronika Kovaříková Peter Solár Iveta Domoráková Andriana Pavliuk-Karachevtseva Alena Hladová Silvia Rybárová Ingrid Hodorová This study aimed to detect the presence of glutathione peroxidase 8 (GPx8) in rat during preimplantation...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6308: The Salt Sensitivity Induced by Disruption of Cell Wall-Associated Kinase 1 (SlWAK1) Tomato Gene Is Linked to Altered Osmotic and Metabolic Homeostasis International Journal of Molecular Sciences doi: 10.3390/ijms21176308 Authors: Victoriano Meco Isabel Egea Ana Ortíz-Atienza Stéphanie Drevensek Elisabeth Esch Fernando J. Yuste-Lisbona Fredy Barneche Wim Vriezen María C. Bolarin Rafael Lozano Francisco B. Flores Tomato cell wall-associated...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6311: Mast Cells Limit Ear Swelling Independently of the Chymase Mouse Mast Cell Protease 4 in an MC903-Induced Atopic Dermatitis-Like Mouse Model International Journal of Molecular Sciences doi: 10.3390/ijms21176311 Authors: Sofie Svanberg Zhiqiang Li Pontus Öhlund Ananya Roy Magnus Åbrink Atopic dermatitis (AD) is a complex, often lifelong allergic disease with severe pruritus affecting around 10% of both humans and dogs. To investigate the role of...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6304: Elastic Modulus of ECM Hydrogels Derived from Decellularized Tissue Affects Capillary Network Formation in Endothelial Cells International Journal of Molecular Sciences doi: 10.3390/ijms21176304 Authors: Mako Kobayashi Junpei Kadota Yoshihide Hashimoto Toshiya Fujisato Naoko Nakamura Tsuyoshi Kimura Akio Kishida Recent applications of decellularized tissue have included the use of hydrogels for injectable materials and three-dimensional (3D)...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6307: Molecular Network and Culture Media Variation Reveal a Complex Metabolic Profile in Pantoea cf. eucrina D2 Associated with an Acidified Marine Sponge International Journal of Molecular Sciences doi: 10.3390/ijms21176307 Authors: Giovanni Andrea Vitale Martina Sciarretta Chiara Cassiano Carmine Buonocore Carmen Festa Valerio Mazzella Laura Núñez Pons Maria Valeria D’Auria Donatella de Pascale The Gram-negative Pantoea eucrina D2 was isolated...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6310: Human Wharton’s Jelly Mesenchymal Stem Cell-Mediated Sciatic Nerve Recovery Is Associated with the Upregulation of Regulatory T Cells International Journal of Molecular Sciences doi: 10.3390/ijms21176310 Authors: Aline Yen Ling Wang Charles Yuen Yung Loh Hsin-Hsin Shen Sing-Ying Hsieh Ing-Kae Wang Chin-Ming Lee Chia-Hsien Lin The acceleration of peripheral nerve regeneration is crucial for functional nerve recovery. Our previous study demonstrated...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6303: Damage-Associated Molecular Patterns and Their Signaling Pathways in Primary Blast Lung Injury: New Research Progress and Future Directions International Journal of Molecular Sciences doi: 10.3390/ijms21176303 Authors: Ning Li Chenhao Geng Shike Hou Haojun Fan Yanhua Gong Primary blast lung injury (PBLI) is a common cause of casualties in wars, terrorist attacks, and explosions. It can exist in the absence of any other outward signs of trauma, and...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6301: Graphene Quantum Dots’ Surface Chemistry Modulates the Sensitivity of Glioblastoma Cells to Chemotherapeutics International Journal of Molecular Sciences doi: 10.3390/ijms21176301 Authors: Giordano Perini Valentina Palmieri Gabriele Ciasca Marcello D’Ascenzo Jacopo Gervasoni Aniello Primiano Monica Rinaldi Daniela Fioretti Chiara Prampolini Federica Tiberio Wanda Lattanzi Ornella Parolini Marco De Spirito Massimiliano Papi ...
Mon Aug 31, 2020 03:00
IJMS, Vol. 21, Pages 6302: Immune Checkpoint Inhibitors as Monotherapy or Within a Combinatorial Strategy in Advanced Hepatocellular Carcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21176302 Authors: Michela Guardascione Giuseppe Toffoli In advanced-stage hepatocellular carcinoma (HCC), systemic treatment represents the standard therapy. Target therapy has marked a new era based on a greater knowledge of molecular disease signaling. Nonetheless, survival outcomes...
Mon Aug 31, 2020 03:00
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