Related ArticlesOlig2 SUMOylation protects against genotoxic damage response by antagonizing p53 gene targeting. Cell Death Differ. 2020 Jun 01;: Authors: Liu H, Weng W, Guo R, Zhou J, Xue J, Zhong S, Cheng J, Zhu MX, Pan SJ, Li Y Abstract Posttranslational modifications of nuclear proteins, including transcription factors, nuclear receptors, and their coregulators, have attracted much attention in cancer research. Although phosphorylation of oligodendrocyte...
Wed Jun 03, 2020 13:33
Related ArticlesA genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor. Nat Commun. 2020 Jun 01;11(1):2707 Authors: Eller C, Heydmann L, Colpitts CC, El Saghire H, Piccioni F, Jühling F, Majzoub K, Pons C, Bach C, Lucifora J, Lupberger J, Nassal M, Cowley GS, Fujiwara N, Hsieh SY, Hoshida Y, Felli E, Pessaux P, Sureau C, Schuster C, Root DE, Verrier ER, Baumert TF Abstract Chronic HBV infection is a major cause of liver disease...
Wed Jun 03, 2020 13:33
Related ArticlesChronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation. Nat Commun. 2020 Jun 01;11(1):2711 Authors: Azazmeh N, Assouline B, Winter E, Ruppo S, Nevo Y, Maly A, Meir K, Witkiewicz AK, Cohen J, Rizou SV, Pikarsky E, Luxenburg C, Gorgoulis VG, Ben-Porath I Abstract p16INK4a (CDKN2A) is a central tumor suppressor, which induces cell-cycle arrest and senescence. Cells expressing p16INK4a...
Wed Jun 03, 2020 13:33
Related ArticlesThe long noncoding RNA EMBP1 inhibits the tumor suppressor miR-9-5p and promotes renal cell carcinoma tumorigenesis. Nefrologia. 2020 May 29;: Authors: Hong Y, Yuan Z, Huang R, Wu Z, Li Y Abstract INTRODUCTION AND OBJECTIVES: Long non-coding RNAs (lncRNAs) have garnered interest because of their roles in cancer progression. We aimed to explore the role of the lncRNA embigin pseudogene 1 (EMBP1)-miR-9-5p axis in renal cell carcinoma...
Wed Jun 03, 2020 13:33
Related ArticlesCancer Chemopreventive Properties of Sulfated Enterolobium cyclocarpum Extract. Nutr Cancer. 2020 Jun 02;:1-13 Authors: Gamal-Eldeen AM, Amer H, Alrehaili AA, Saleh A, Al Ghamdi AE, Hawsawi NM, Salman A, Raafat BM Abstract Enterolobium cyclocarpum (EC) is an edible plant and a gum source for food industries. Its sulfated polysaccharide extract (SEC) was examined for cancer chemopreventive properties to estimate its anti-tumor activity....
Wed Jun 03, 2020 13:33
Related ArticlesCDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication. Genes (Basel). 2020 May 28;11(6): Authors: Mansilla SF, de la Vega MB, Calzetta NL, Siri SO, Gottifredi V Abstract p21Waf/CIP1 is a small unstructured protein that binds and inactivates cyclin-dependent kinases (CDKs). To this end, p21 levels increase following the activation of the p53 tumor suppressor. CDK inhibition by p21 triggers cell-cycle arrest in the...
Wed Jun 03, 2020 13:33
Related ArticlesTargeted disruption of the BCL9/β-catenin interaction by endosomal-escapable nanoparticles functionalized with an E-cadherin-derived peptide. Nanotechnology. 2020 Mar 13;31(11):115102 Authors: Yang G, Zhang J, You W, Zhao X, Hou P, He W, Yan J, Guo H Abstract Abnormal activation of the Wnt/β-catenin signaling pathway, which underlies multiple malignancies, promotes tumor progression; drugs that can block this pathway are therefore highly...
Wed Jun 03, 2020 13:33
Related ArticlesExtension of the ML-EM algorithm for dose estimation using PET in proton therapy: application to an inhomogeneous target. Phys Med Biol. 2020 Jun 02;: Authors: Masuda T, Nishio T, Sano A, Karasawa K Abstract Positron emission tomography (PET) has been used forinvivotreatment verification, mainly for range verification, in proton therapy. Evaluating the direct dose from PET measurements remains challenging; however, it is highly desirable...
Wed Jun 03, 2020 14:30
Related ArticlesDuration of radiation therapy is associated with worse survival in head and neck cancer. Oral Oncol. 2020 May 30;108:104819 Authors: Mazul AL, Stepan KO, Barrett TF, Thorstad WL, Massa S, Adkins DR, Daly MD, Rich JT, Paniello RC, Pipkorn P, Zevallos JP, Jackson RS, Kang SY, Puram SV Abstract INTRODUCTION: Delays in radiation are multifactorial, frequent, and associated with poor outcomes. This study investigates the effect of both...
Wed Jun 03, 2020 14:30
Related ArticlesMajor and minor salivary gland tumours. Crit Rev Oncol Hematol. 2020 May 18;152:102959 Authors: Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ Abstract Salivary glands carcinomas are very rare epithelial malignant tumors. In 2013 in Europe, 7800 new diagnoses were estimated, 8.5 % of all head and neck cancer. The last WHO classification (2017) counts more than 20 malignant histotypes, this variety as well as the rarity of some of...
Wed Jun 03, 2020 14:30
Related ArticlesSafeness, subjective and objective changes after turbinate surgery in pediatric patients: A systematic review. Int J Pediatr Otorhinolaryngol. 2020 May 21;135:110128 Authors: Calvo-Henriquez C, Capasso R, Martínez-Capoccioni G, Rangel-Chaves J, Liu SY, O'Connor-Reina C, Lechien JR, Martin-Martin C Abstract OBJECTIVE: Inferior turbinates are the main structure related to impaired nasal breathing. When medical treatment fails, surgery...
Wed Jun 03, 2020 14:30
Related ArticlesPredictors of the need for tracheostomy in the neonatal intensive care unit. Int J Pediatr Otorhinolaryngol. 2020 May 19;135:110122 Authors: Windsor AM, Kiell EP, Sobol SE Abstract OBJECTIVES: Many infants in the neonatal intensive care unit (NICU) require prolonged periods of respiratory support. Microlaryngoscopy and bronchoscopy (MLB) is performed to evaluate for airway pathology and facilitate decision-making regarding further...
Wed Jun 03, 2020 14:30
Related Articles"Hot Zones" for Otolaryngologists: Assessing the geographic distribution of aerosol-generating procedures amidst the COVID-19 pandemic. Am J Otolaryngol. 2020 May 27;41(4):102550 Authors: Quereshy HA, Jella TK, Ruthberg JS, Kocharyan A, D'Anza B, Maronian N, Otteson TD Abstract OBJECTIVE: Given high COVID-19 viral load and aerosolization in the head and neck, otolaryngologists are subject to uniquely elevated viral exposure in most...
Wed Jun 03, 2020 14:30
Related ArticlesObstructive sleep apnea caused by acromegaly: Case report. Cranio. 2020 Jun 02;:1-3 Authors: Zhou N, Ho JTF, De Vries N, De Lange J Abstract BACKGROUND: Acromegaly is an uncommon syndrome caused by growth hormone-producing pituitary adenoma or pituitary gland hypertrophy. Acromegaly is known to be characterized by progressive somatic disfigurement and a wide range of systematic manifestations. This case study describes a rare case...
Wed Jun 03, 2020 14:30
Related ArticlesEAACI Biologicals Guidelines - Recommendations for severe asthma. Allergy. 2020 Jun 02;: Authors: Agache I, Akdis C, Akdis M, Canonica GW, Casale T, Chivato T, Corren J, Chu DK, Del Giacco S, Eiwegger T, Flood B, Firinu D, Gern JE, Hamelmann E, Hanania N, Hernández-Martín I, Knibb R, Mäkelä M, Nair P, O Mahony L, Papadopoulos NG, Papi A, Park HS, Pérez de Llano L, Pfaar O, Quirce S, Sastre J, Shamji M, Schwarze J, Palomares O, Jutel M Abstract...
Wed Jun 03, 2020 14:30
Related ArticlesRecognizing and Mitigating the Threat Posed by COVID-19 to Otolaryngologists: A UK Perspective. Laryngoscope. 2020 Jun 02;: Authors: Kumar N, Garas G, Swift AC, O'Donoghue GM PMID: 32484943 [PubMed - as supplied by publisher]
Wed Jun 03, 2020 14:30
Related ArticlesIn Response to COVID-19 and the Otolaryngologist: Preliminary Evidence-Based Review. Laryngoscope. 2020 Jun 02;: Authors: Vukkadala N, Rosenthal E, Patel ZM PMID: 32484933 [PubMed - as supplied by publisher]
Wed Jun 03, 2020 14:30
Related ArticlesThe need for improved transition and services for adolescent and young adult patients with allergy and asthma in all settings. Allergy. 2020 Jun 02;: Authors: Roberts G, Vazquez-Ortiz M, Khaleva E, DunnGalvin A, Gore C, Marchisotto MJ, Mortz CG, Pfaar O, Sánchez A Abstract Adolescence is a challenging time for both patients and healthcare providers. Adolescent patients need to learn all the knowledge and skills required to competently...
Wed Jun 03, 2020 14:30
Related ArticlesTanshinone IIA suppresses hypoxia-induced apoptosis in medial vestibular nucleus cells via a Skp2/BKCa axis. Curr Pharm Des. 2020 Jun 02;: Authors: Zhu JJ, Wu SH, Chen X, Jiang TT, Li XQ, Li JM, Yan Y, Wu XJ, Liu YY, Dong P Abstract BACKGROUND: The aim of the present study was to investigate the protective effects of Tanshinone IIA (Tan IIA) on hypoxia induced injury in medial vestibular nucleus (MVN) cells. METHODS: An...
Wed Jun 03, 2020 14:30
Related ArticlesPostoperative Outcomes of Branchial Cleft Cyst Excision in Children and Adults: An NSQIP Analysis. Otolaryngol Head Neck Surg. 2020 Jun;162(6):959-968 Authors: Moroco AE, Saadi RA, Patel VA, Lehman EB, Wilson MN Abstract OBJECTIVE: Identify risk factors and perioperative morbidity for patients undergoing branchial cleft cyst (BCC) excision. STUDY DESIGN: Cross-sectional analysis. SETTING: American College of Surgeons...
Wed Jun 03, 2020 14:30
Related ArticlesTelemedicine and the Interdisciplinary Clinic Model: During the COVID-19 Pandemic and Beyond. Otolaryngol Head Neck Surg. 2020 Jun 02;:194599820932167 Authors: Zughni LA, Gillespie AI, Hatcher JL, Rubin AD, Giliberto JP Abstract The emergence of the novel coronavirus disease 2019 (COVID-19) and the subsequent need for physical distancing have necessitated a swift change in health care delivery. Prior to the COVID-19 outbreak, many...
Wed Jun 03, 2020 14:30
Related ArticlesRhinologic Practice Special Considerations During COVID-19: Visit Planning, Personal Protective Equipment, Testing, and Environmental Controls. Otolaryngol Head Neck Surg. 2020 Jun 02;:194599820933169 Authors: Howard BE, Lal D Abstract As rhinologists return to practice amid SARS-CoV-2, special considerations are warranted given the unique features of their subspecialty. Rhinologist manipulation of nasal tissue, proximity, and frequent...
Wed Jun 03, 2020 14:30
Related ArticlesAlternations of Blood Pressure Before and After OSA Surgery. Otolaryngol Head Neck Surg. 2020 Jun 02;:194599820926137 Authors: Tsai MH, Lin PW, Lin HC, Friedman M, Salapatas AM, Lu YH, Su MC, Lin MC Abstract OBJECTIVE: To investigate the changes of blood pressure (BP) on patients with obstructive sleep apnea/hypopnea syndrome (OSA) before and after upper airway surgery. DESIGN: Case series with chart review. SETTING:...
Wed Jun 03, 2020 14:30
Related ArticlesGuidance for contemporary use of biologics in management of chronic rhinosinusitis with nasal polyps: Discussion from an NIH sponsored workshop. Int Forum Allergy Rhinol. 2020 Jun 02;: Authors: Roland LT, Smith TL, Schlosser RJ, Soler ZM, Peters AT, Laidlaw TM, Bleier BS, Ramakrishnan V, Toskala E, Kennedy DW, Luong AU Abstract Biologic medications are emerging as options for treating chronic rhinosinusitis with nasal polyps. Several...
Wed Jun 03, 2020 14:30
Related ArticlesOutcomes after radiation therapy for T2N0/stage II glottic squamous cell carcinoma. Head Neck. 2020 Jun 02;: Authors: Al Feghali KA, Youssef BY, Mohamed ASR, Hilal L, Smith BD, Abu-Gheida I, Farha G, Gunn GB, Phan J, Lewin J, Thekdi A, Morrison WH, Garden AS, Fuller CD, Rosenthal DI Abstract BACKGROUND: We report outcomes for patients with T2N0M0 glottic squamous cell carcinoma (SCC) treated with radiation therapy (RT). ...
Wed Jun 03, 2020 14:30
Related ArticlesPredictive value of computed tomography in identifying extranodal extension in human papillomavirus-positive versus human papillomavirus-negative head and neck cancer. Head Neck. 2020 Jun 02;: Authors: Yan F, Byun YJ, Nguyen SA, Stalcup ST, Day TA Abstract Pathologic extranodal extension (pENE) impacts treatment planning and is an important prognostic indicator for patients with head and neck squamous cell carcinoma (HNSCC). Computed...
Wed Jun 03, 2020 14:30
Related ArticlesPredicting COVID-19 Incidence Using Anosmia and Other COVID-19 Symptomatology: Preliminary Analysis Using Google and Twitter. Otolaryngol Head Neck Surg. 2020 Jun 02;:194599820932128 Authors: Panuganti BA, Jafari A, MacDonald B, DeConde AS Abstract OBJECTIVE: To determine the relative correlations of Twitter and Google Search user trends concerning smell loss with daily coronavirus disease 2019 (COVID-19) incidence in the United States,...
Wed Jun 03, 2020 14:30
Related ArticlesVoice Quality, Function, and Quality of Life for Laryngeal Cancer: A Prospective Longitudinal Study Up to 24 Months Following Radiotherapy. Ear Nose Throat J. 2020 Jun 02;:145561320929941 Authors: Tuomi L, Karlsson T Abstract OBJECTIVE: To study the potential changes of health-related quality of life (HRQL), voice quality, and communicative function up to 24 months following radiotherapy for patients with laryngeal cancer. ...
Wed Jun 03, 2020 14:30
Related ArticlesTime for a Paradigm Shift in Head and Neck Cancer Management During the COVID-19 Pandemic. Otolaryngol Head Neck Surg. 2020 Jun 02;:194599820931789 Authors: Han AY, Miller JE, Long JL, St John MA Abstract OBJECTIVE: The coronavirus disease 2019 (COVID-19) pandemic has caused physicians and surgeons to consider restructuring traditional cancer management paradigms. We aim to review the current evidence regarding the diagnosis and management...
Wed Jun 03, 2020 14:30
Related ArticlesImplantable Drug Reservoir Devices for Inner Ear Delivery of Pharmacotherapeutics. Otolaryngol Head Neck Surg. 2020 Jun 02;:194599820930229 Authors: Kita A, Saldate J, Chang C, Chellappa N, Jong J, Matsuda R, Schmidt A, Shih B, Shafqat I, Schoettler K, Acharya S, Seidlits S, Hoffman L Abstract OBJECTIVE: Cisplatin is a platinum-based chemotherapeutic drug that secondarily induces toxicity in inner ear sensory epithelia, contributing...
Wed Jun 03, 2020 14:30
Related ArticlesPatterns of Failure in Patients With Head and Neck Squamous Cell Carcinomas of Unknown Primary Treated With Chemoradiotherapy. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820905826 Authors: Dhouib F, Bertaut A, Maingon P, Siala W, Daoud J, Aubignac L, Lestrade L, Crehange G, Vulquin N Abstract BACKGROUND: To evaluate the patterns of failure in patients treated for head and neck carcinoma of unknown primary and to discuss treatment...
Wed Jun 03, 2020 14:30
Related ArticlesLaryngeal Electromyography-Guided Hyaluronic Acid Vocal Fold Injections for Glottic Insufficiency. Ann Otol Rhinol Laryngol. 2020 Jun 02;:3489420931556 Authors: Liu AQ, Singer J, Lee T, Hu A Abstract OBJECTIVES: To assess voice outcomes using the novel technique of in-office laryngeal electromyography-guided vocal fold injections (LEVFI) with hyaluronic acid to treat glottal insufficiency. Secondary objectives included determining...
Wed Jun 03, 2020 14:30
Related ArticlesApplicant-to-Residency Program Communication: Does It Matter? Ann Otol Rhinol Laryngol. 2020 Jun 02;:3489420928381 Authors: Solis RN, Quesada PR, Ma C, Olinde LM, Diaz RC Abstract OBJECTIVES: To elucidate the frequency and types of pre- and post-interview communication that applicants engage with programs, to garner the perceptions of both applicants and program directors (PDs), and determine if communication influences outcomes....
Wed Jun 03, 2020 14:30
Related ArticlesFactors Affecting Post-Anesthesia Care Unit Length of Stay in Pediatric Patients after an Adenotonsillectomy. Ann Otol Rhinol Laryngol. 2020 Jun 02;:3489420931557 Authors: Anandan D, Zhao S, Whigham AS Abstract OBJECTIVES: (1) To identify clinical factors and perioperative practices that correlate with longer length of stay (LOS) in the post-anesthesia care unit (PACU) after adenotonsillectomy (T&A) in pediatric populations. (2) To...
Wed Jun 03, 2020 14:30
Related ArticlesReducing the morbidity of parotidectomy for benign pathology. ANZ J Surg. 2020 Jun 02;: Authors: Petrides GA, Subramaniam N, Pham M, Clark JR Abstract BACKGROUND: Conservative surgical approaches, reconstructive techniques and technology are increasingly used in parotid surgery. The aim of this study was to determine the surgeon-modifiable factors which impact the rates of post-operative complications following parotidectomy for benign...
Wed Jun 03, 2020 13:28
Related ArticlesReliability and prognostic value of radiomic features are highly dependent on choice of feature extraction platform. Eur Radiol. 2020 Jun 01;: Authors: Fornacon-Wood I, Mistry H, Ackermann CJ, Blackhall F, McPartlin A, Faivre-Finn C, Price GJ, O'Connor JPB Abstract OBJECTIVE: To investigate the effects of Image Biomarker Standardisation Initiative (IBSI) compliance, harmonisation of calculation settings and platform version on the...
Wed Jun 03, 2020 13:28
Related ArticlesOrgan of Corti size is governed by Yap/Tead-mediated progenitor self-renewal. Proc Natl Acad Sci U S A. 2020 Jun 01;: Authors: Gnedeva K, Wang X, McGovern MM, Barton M, Tao L, Trecek T, Monroe TO, Llamas J, Makmura W, Martin JF, Groves AK, Warchol M, Segil N Abstract Precise control of organ growth and patterning is executed through a balanced regulation of progenitor self-renewal and differentiation. In the auditory sensory epithelium-the...
Wed Jun 03, 2020 13:28
Related ArticlesCAMSAP3 facilitates basal body polarity and the formation of the central pair of microtubules in motile cilia. Proc Natl Acad Sci U S A. 2020 Jun 01;: Authors: Robinson AM, Takahashi S, Brotslaw EJ, Ahmad A, Ferrer E, Procissi D, Richter CP, Cheatham MA, Mitchell BJ, Zheng J Abstract Synchronized beating of cilia on multiciliated cells (MCCs) generates a directional flow of mucus across epithelia. This motility requires a "9 + 2"...
Wed Jun 03, 2020 13:28
Related ArticlesConsensus statement. Corticosteroid therapy in ENT in the context of the COVID-19 pandemic. Eur Ann Otorhinolaryngol Head Neck Dis. 2020 May 04;: Authors: Herman P, Vincent C, Parietti Winkler C, Loundon N, Couloigner V, Tankere F, Tringali S, Gallet P, Papon JF, Montava M, Lavieille JP, Charpiot A, Schmerber S Abstract This consensus statement about the indications and modalities of corticosteroid treatment in the context of the...
Wed Jun 03, 2020 13:28
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.