Related ArticlesSystematic review and meta-analysis as a structured platform for teaching principles of experimentation. Adv Physiol Educ. 2020 Sep 01;44(3):276-285 Authors: Land SC, Booth D Abstract Access to knowledge has never been easier in the internet age, and so it is important that students develop skills to discriminate undependable information from reliably investigated research. We have created an exercise that teaches good research practice...
Wed Jun 03, 2020 19:46
Related ArticlesStudent response to a cooperative learning element within a large physiology class setting: lessons learned. Adv Physiol Educ. 2020 Sep 01;44(3):269-275 Authors: Essop MF, Beselaar L Abstract Physiology students grapple with large amounts of subject content and hence memorize facts to pass examinations. In parallel, students display limited critical-thinking and creative skills, integration abilities, and/or a deeper engagement with subject...
Wed Jun 03, 2020 19:46
Related ArticlesA primer on tissue pH and local anesthetic potency. Adv Physiol Educ. 2020 Sep 01;44(3):305-308 Authors: Pope RLE, Brown AM Abstract The relationship between pH, pKa, and degree of local anesthetic ionization is quantified by the Henderson-Hasselbalch equation. As presented in standard textbooks, the effect of pH on the degree of ionization of any particular local anesthetic is not immediately clear due to the x-axis displaying pH - pKa,...
Wed Jun 03, 2020 19:46
Related ArticlesPhysiology without borders: report on physiology education workshops in India-IUPS Initiatives (2018-2019). Adv Physiol Educ. 2020 Sep 01;44(3):309-313 Authors: Chandran DS, Muthukrishnan SP, Barman SM, Peltonen LM, Ghosh S, Sharma R, Bhattacharjee M, Rathore BB, Carroll R, Sengupta J, Ghosh D PMID: 32484399 [PubMed - as supplied by publisher]
Wed Jun 03, 2020 19:46
Related ArticlesIsolated gallbladder metastasis of melanoma: Case report. Int J Surg Case Rep. 2020 May 14;71:311-314 Authors: D'Urso Vilar GG, Iriarte F, Speisky D, Bregante ML, Quildrian SD Abstract BACKGROUND: Although metastatic melanoma is most frequently found in liver, lungs, and brain, most metastases found in the gallbladder are from melanoma. Here, we present a case of isolated metastatic melanoma found during cholecystectomy. PRESENTATION...
Wed Jun 03, 2020 17:51
Related ArticlesSuccessful excision of a retrorectal cyst through trans-sacral approach: A case report. Int J Surg Case Rep. 2020 May 23;71:307-310 Authors: Alsofyani TM, Aldossary MY, AlQahtani FF, Sabr K, Balhareth A Abstract INTRODUCTION: Retrorectal cysts are rare congenital cystic lesions usually diagnosed in middle-aged women. They are generally asymptomatic; however, local pressure may result in complications. Pain or discomfort in the pelvic,...
Wed Jun 03, 2020 17:51
Related ArticlesFeatures of rare primary cardiac angiosarcoma in multimodality imaging. Jpn J Clin Oncol. 2020 Jun 02;: Authors: Wan Q, Song Z, Zhao J, Wan F, Zhang Q PMID: 32484217 [PubMed - as supplied by publisher]
Wed Jun 03, 2020 14:44
Related ArticlesHAGLROS is overexpressed and promotes non-small cell lung cancer migration and invasion. Jpn J Clin Oncol. 2020 Jun 02;: Authors: Chen Y, Shen T, Ding X, Cheng L, Sheng L, Du X Abstract INTRODUCTION: Non-small cell lung cancer was one of the most common and deadly cancers worldwide. Long non-coding RNAs had been implicated in multiple human cancers, including non-small cell lung cancer. In this study, we focused on a novel long non-coding...
Wed Jun 03, 2020 14:44
Related ArticlesFactors associated with health-related quality of life in patients with glioma: impact of symptoms and implications for rehabilitation. Jpn J Clin Oncol. 2020 Jun 02;: Authors: Umezaki S, Shinoda Y, Mukasa A, Tanaka S, Takayanagi S, Oka H, Tagawa H, Haga N, Yoshino M Abstract OBJECTIVE: The factors associated with health-related quality of life in patients with glioma remain unclear; particularly, the impact of symptoms on quality of...
Wed Jun 03, 2020 14:44
Related ArticlesAcquired reactive perforating collagenosis: A case report and review of the literature. Medicine (Baltimore). 2020 May 29;99(22):e20391 Authors: Zhang X, Yang Y, Shao S Abstract INTRODUCTION: Acquired reactive perforating collagenosis (ARPC) is a rare skin disorder, which is associated with various internal diseases and even malignant neoplasms. A comprehensive knowledge of the concomitant diseases in ARPC patients is helpful to decrease...
Wed Jun 03, 2020 13:45
Related ArticlesSpontaneous bacterial peritonitis caused by Campylobacter Coli in cirrhotic patient: A rare case report (CARE-compliant). Medicine (Baltimore). 2020 May 22;99(21):e19887 Authors: Wang CH, Tai TH, Weng SY, Yeh SW, Shiue SJ, Jargalsaikhan G, Wu MS Abstract INTRODUCTION: Spontaneous bacterial peritonitis (SBP) is a fatal infection in patients. It often happens in patients with cirrhosis, cancer or diabetes, and is caused mostly by Enterobacteriaceae....
Wed Jun 03, 2020 13:45
Related ArticlesCortical Laminar Necrosis as a Result of Status Epilepticus After Resection of Parafalcal Meningioma. Surg Technol Int. 2020 May 28;36:159-177 Authors: La Rocca G, Della Pepa GM, Gaudino S, Sabatino G, Zoia C, Raffa G, Altieri R, Mazzucchi E Abstract Status epilepticus during the post-operative period is a rare complication for neurosurgery patients. Acute encephalopathic syndromes can present a diagnostic challenge due to the wide range...
Wed Jun 03, 2020 13:45
Related ArticlesExosomes as a Surrogate Marker for Autophagy in Peripheral Blood, Correlative Data from Phase I Study of Chloroquine in Combination with Carboplatin/Gemcitabine in Advanced Solid Tumors. Asian Pac J Cancer Prev. 2019 Dec 01;20(12):3789-3796 Authors: Abdel Karim N, Gaber O, Eldessouki I, Bahassi EM, Morris J Abstract BACKGROUND: Autophagy is a catabolic process, utilized constitutionally by body cells to recycle nutrients and to remove...
Wed Jun 03, 2020 13:45
Related ArticlesChronic lymphopenia and neutropenia in a dog with large granular lymphocytic leukemia. Vet Clin Pathol. 2019 Dec;48(4):721-724 Authors: Museux K, Turinelli V, Rosenberg D, Rodriguez Piñeiro I Abstract T-cell large granular lymphocytic leukemia (T-cell LGLL) is the most common presentation of chronic lymphocytic leukemia (CLL) in dogs. Aleukemic or subleukemic leukemia is a particularly rare variation in both humans and dogs, where bone...
Wed Jun 03, 2020 13:45
Related ArticlesCutaneous Syncytial Myoepithelioma: A Nondescript Skin Tumor With Serious Diagnostic Pitfalls. Int J Surg Pathol. 2020 Feb;28(1):63-67 Authors: Wales C, Diamond S, Hinds B Abstract Cutaneous syncytial myoepithelioma (CSM) is a rare tumor with a nondescript clinical presentation in the skin. It represents a relatively uncommon diagnostic entity with approximately 50 examples in the literature to date. We present a 36-year-old man with...
Wed Jun 03, 2020 13:45
Related ArticlesPrenatally diagnosed congenital hemangioma with elevated middle cerebral artery peak systolic velocity mimicking the Kasabach-Merritt phenomenon: A case report. J Obstet Gynaecol Res. 2019 Dec;45(12):2456-2460 Authors: Someya M, Sasahara J, Yamamoto S, Sawada A, Nishikawa M, Ishii K Abstract Congenital hemangioma is a rare vascular tumor that develops prenatally, and a large congenital hemangioma may be accompanied by the Kasabach-Merritt...
Wed Jun 03, 2020 13:45
Related ArticlesMutational Profile Using Next-Generation Sequencing May Aid in the Diagnosis and Treatment of Urachal Adenocarcinoma. Int J Surg Pathol. 2020 Feb;28(1):51-59 Authors: Cornejo KM, Cosar EF, Paner GP, Yang P, Tomaszewicz K, Meng X, Mehta V, Sirintrapun SJ, Barkan GA, Hutchinson L Abstract Objectives. The rare urachal adenocarcinoma (UAC) of the bladder has striking morphologic and immunohistochemical overlap with colorectal adenocarcinoma...
Wed Jun 03, 2020 13:45
Related ArticlesJuxtaglomerular Cell Tumor With Atypical Pathological Features: Report of a Case and Review of Literature. Int J Surg Pathol. 2020 Feb;28(1):87-91 Authors: Hagiya A, Zhou M, Hung A, Aron M Abstract Juxtaglomerular cell tumor (JGCT) is a rare renal tumor with a predominantly benign clinical course. It affects young adults, who often present with hypertension, hypokalemia, and hyperaldosteronism. The tumor cells are round to spindle-shaped...
Wed Jun 03, 2020 13:45
Related ArticlesRhabdomyosarcoma of the Adult Prostate: A Case Report With Complete Molecular Profile. Int J Surg Pathol. 2020 Feb;28(1):92-98 Authors: Olivas AD, Antic T Abstract Primary rhabdomyosarcoma of the adult prostate is rare and associated with an aggressive clinical course. Given the limited number of cases reported about the prostate, little is known about the impact of molecular mutations on tumor biology and prognosis in adults. In this...
Wed Jun 03, 2020 13:45
Related ArticlesKaposi Sarcoma in Association With an Extracavitary Primary Effusion Lymphoma Showing Unusual Intravascular Involvement: Report of a Case Harboring a FAM175A Germline Mutation. Am J Dermatopathol. 2020 Jan;42(1):55-60 Authors: Kastnerova L, Belousova IE, Michal M, Ptakova N, Michal M, Kazakov DV Abstract Primary effusion lymphoma (PEL) is a rare form of aggressive B-cell lymphoma characterized by a malignant serous effusion involving...
Wed Jun 03, 2020 13:45
Related ArticlesA Focus of Differentiated Myeloid Sarcoma in a Ligation Specimen of the Fallopian Tube: No Evidence of Hematologic Abnormality in 18 Years of Follow-up Despite Absence of Treatment. Int J Surg Pathol. 2020 Feb;28(1):99-101 Authors: Castro E, Morales L, Zreik R, Donner LR Abstract A 0.2-cm intramural focus composed predominantly of myelocytes and metamyelocytes, many CD3+, CD43+ T-lymphocytes, scanty CD20+ B-lymphocytes, rare mast cells,...
Wed Jun 03, 2020 13:45
Related ArticlesPD-L1/PD-1 Expression in Endometrial Clear Cell Carcinoma: A Potential Surrogate Marker for Clinical Trials. Int J Surg Pathol. 2020 Feb;28(1):31-37 Authors: Jin C, Hacking S, Liang S, Nasim M Abstract Background. Endometrial clear cell carcinoma (ECCC) represents a rare subtype of endometrial cancer. Recently, immunotherapeutic drugs targeting programmed cell death protein 1 (PD-1)/programmed death ligand-1 (PD-L1) was associated with...
Wed Jun 03, 2020 13:45
Related ArticlesMelanotic Schwannoma of the Vulva: A Case Report and Review of the Literature. Am J Dermatopathol. 2020 Jan;42(1):46-51 Authors: Cohen JN, Yeh I, LeBoit PE Abstract Melanotic schwannoma is a pigmented tumor of peripheral nerve differentiation. Primary cutaneous presentations are extremely rare, as the bulk of melanotic schwannomas tend to develop in paraspinal and axial sites. Tumors arise sporadically and in the setting of the Carney...
Wed Jun 03, 2020 13:45
Related ArticlesCore Biopsies from Prostate Cancer Patients in Active Surveillance Protocols Harbor PTEN and MYC Alterations. Eur Urol Oncol. 2019 05;2(3):277-285 Authors: Gandellini P, Casiraghi N, Rancati T, Benelli M, Doldi V, Romanel A, Colecchia M, Marenghi C, Valdagni R, Demichelis F, Zaffaroni N Abstract BACKGROUND: Genomic characterization of prostate cancer (PCa) biopsies may improve criteria for the selection of patients suitable for active...
Wed Jun 03, 2020 13:45
Related ArticlesPretibial Pruritic Papular Dermatitis: A Comprehensive Clinical and Pathologic Review of Cases at a Single Institution. Am J Dermatopathol. 2020 Jan;42(1):16-19 Authors: Flores S, Wada DA, Florell SR, Bowen AR Abstract BACKGROUND: Studies characterizing clinical and pathologic details of pretibial pruritic papular dermatitis (PPPD) are scarce. Several cases of PPPD at our institution have displayed lymphocyte atypia and CD30 positivity,...
Wed Jun 03, 2020 13:45
Related ArticlesSlippery Nanoparticles as a Diffusion Platform for Mucin Producing Gastrointestinal Tumors. Ann Surg Oncol. 2020 Jan;27(1):76-84 Authors: Khalili M, Zhou H, Thadi A, Daniels L, Fan Z, Morano WF, Ang J, Goldstein E, Polyak B, Mapow BC, Cheng H, Bowne WB Abstract BACKGROUND: Treatment failure in pseudomyxoma peritonei (PMP) is partly attributed to the ineffective delivery of therapeutics through dense mucinous tumor barriers. We modified...
Wed Jun 03, 2020 13:45
Related ArticlesMummified Cells are a Common Finding in Cutaneous Hodgkin Lymphoma and Can Be Used as a Diagnostic Clue. Am J Dermatopathol. 2020 Jan;42(1):24-28 Authors: Kastnerova L, Belousova IE, Hadravsky L, Kerl H, Cerroni L, Kerl K, Boudova L, Jindra P, Cerna K, Michal M, Kazakov DV Abstract Specific cutaneous involvement in Hodgkin lymphoma is rare. In cutaneous lesions, the diagnosis is usually based on the recognition of diagnostic Reed-Sternberg...
Wed Jun 03, 2020 13:45
Related ArticlesSarcome-13/OS2016 trial protocol: a multicentre, randomised, open-label, phase II trial of mifamurtide combined with postoperative chemotherapy for patients with newly diagnosed high-risk osteosarcoma. BMJ Open. 2019 05 19;9(5):e025877 Authors: Brard C, Piperno-Neumann S, Delaye J, Brugières L, Hampson LV, Le Teuff G, Le Deley MC, Gaspar N Abstract INTRODUCTION: The controversial results on the mifamurtide efficacy associated with chemotherapy,...
Wed Jun 03, 2020 13:45
Related ArticlesPerformance analysis of AL amyloidosis cardiac biomarker staging systems with special focus on renal failure and atrial arrhythmia. Haematologica. 2019 07;104(7):1451-1459 Authors: Dittrich T, Benner A, Kimmich C, Siepen FAD, Veelken K, Kristen AV, Bochtler T, Katus HA, Müller-Tidow C, Hegenbart U, Schönland SO Abstract Systemic light chain amyloidosis is a rare and life-threatening disorder, for which accurate risk stratification is...
Wed Jun 03, 2020 13:45
Related ArticlesTargeting BCL2 with venetoclax is a promising therapeutic strategy for "double-proteinexpression" lymphoma with MYC and BCL2 rearrangements. Haematologica. 2019 07;104(7):1417-1421 Authors: Uchida A, Isobe Y, Asano J, Uemura Y, Hoshikawa M, Takagi M, Miura I Abstract The so-called "double-hit" and "double-protein-expression" lymphoma with MYC and BCL2 rearrangements is a rare, mature B-cell neoplasm characterized by a germinal center...
Wed Jun 03, 2020 13:45
Related ArticlesLipomas of the Brachial Plexus: A Case Series and Review of the Literature. Hand (N Y). 2019 05;14(3):333-338 Authors: Graf A, Yang K, King D, Dzwierzynski W, Sanger J, Hettinger P Abstract BACKGROUND: Lipomas are common benign tumors. When they develop in proximity to peripheral nerves, they can cause neurologic symptoms secondary to mass effect. Previous reports have shown symptom resolution after removal of lipomas compressing various...
Wed Jun 03, 2020 13:45
Related ArticlesMetastatic Tracheal Tumor of Thyroid Origin: Endoscopic Diode Laser Treatment Combined With Thyroidectomy, Radioactive Iodine, and Radiotherapy. Ear Nose Throat J. 2020 Jun 02;:145561320931214 Authors: Karkos PD, Koskinas IS, Tsiropoulos G, Goupou E, Hatzibougias D Abstract Tracheal metastasis from papillary thyroid carcinoma (PTC) is an unprecedented and rare entity. We present the case of a 65 year-old lady who suffered from dyspnea...
Wed Jun 03, 2020 17:42
Abstract Human scabies is a contagious skin infestation caused by the parasitic mite Sarcoptes scabiei var. hominis . It is a common skin disease worldwide that occurs not only in the underprivileged sections of society but also in developed countries. In 2009, World Health Organisation (WHO) recognized scabies as “neglected tropical disease (NTD)” or NTD thus emphasizing the need for community awareness and proper treatment strategies. This review attempts to summarise the varied clinical presentation...
Tue Jun 02, 2020 12:09
Related ArticlesDevelopment of four ruthenium polypyridyl complexes as antitumor agents: Design, biological evaluation and mechanism investigation. J Inorg Biochem. 2020 May 19;208:111104 Authors: Jiang GB, Zhang WY, He M, Gu YY, Bai L, Wang YJ, Yi QY, Du F Abstract Ruthenium complexes are expected to be new opportunities for the development of antitumor agents. Herein, four ruthenium polypyridyl complexes ([Ru(bpy)2(CAPIP)](ClO4)2 (Ru(II)-1, bpy = 2,2'-bipyridine;...
Wed Jun 03, 2020 14:32
Related ArticlesExpanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases. Eur J Med Chem. 2020 May 25;200:112439 Authors: Elzahhar PA, Abd El Wahab SM, Elagawany M, Daabees H, Belal ASF, El-Yazbi AF, Eid AH, Alaaeddine R, Hegazy RR, Allam RM, Helmy MW, Bahaa Elgendy, Angeli A, El-Hawash SA, Supuran CT Abstract Cancer is a multifactorial disorder involving...
Wed Jun 03, 2020 14:32
Related ArticlesFolate targeted lipid chitosan hybrid nanoparticles for enhanced anti-tumor efficacy. Nanomedicine. 2020 May 30;:102228 Authors: Khan MM, Madni A, Filipczak N, Pan J, Rehman M, Rai N, Attia SA, Torchilin VP Abstract Folic acid is often used for active targeting of tumor cells to enhance therapeutic outcomes. Here, folic acid was conjugated with chitosan and folate-conjugated chitosan-lipid hybrid nanoparticles were prepared by ionic...
Wed Jun 03, 2020 14:32
Related ArticlesA steroidal saponin isolated from Allium chinense simultaneously induces apoptosis and autophagy by modulating the PI3K/Akt/mTOR signaling pathway in human gastric adenocarcinoma. Steroids. 2020 May 30;:108672 Authors: Xu J, Zhang M, Lin X, Wang Y, He X Abstract Allium chinense, as a side dish on Asian table, is often used in folk medicine for its health benefits. (25R)-5α-spirostan-3β-yl-3-O-acetyl-O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside...
Wed Jun 03, 2020 14:32
Related ArticlesCHK2 is essential for spindle assembly and DNA repair during the first cleavage of mouse embryos. Aging (Albany NY). 2020 Jun 02;12: Authors: Li XH, Li WJ, Ju JQ, Pan MH, Xu Y, Sun MH, Li M, Sun SC Abstract The quality of the early embryo is critical for embryonic development and implantation. Errors during cleavage lead to aneuploidy in embryos. As a cell cycle checkpoint protein, CHK2 participates in DNA replication, cell cycle...
Wed Jun 03, 2020 14:32
Related ArticlesThe deubiquitinating enzyme UCHL1 promotes resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase. Theranostics. 2020;10(13):6048-6060 Authors: Ding X, Gu Y, Jin M, Guo X, Xue S, Tan C, Huang J, Yang W, Xue M, Zhou Q, Wang W, Zhang Y Abstract Rationale: Resistance to pemetrexed (PEM)-based chemotherapy is a major cause of progression in non-small cell lung cancer (NSCLC) patients. The deubiquitinating...
Wed Jun 03, 2020 13:33
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