Related ArticlesProspective evaluation of Floppy Eyelid Syndrome at baseline and after CPAP therapy. Curr Eye Res. 2020 Jun 01;: Authors: Vieira MJ, Silva MJ, Lopes N, Moreira C, Carvalheira F, Sousa JP Abstract PURPOSE/AIM: Floppy eyelid syndrome (FES) is an ocular manifestation of obstructive sleep apnea (OSA), but no studies have analyzed whether it can be improved by nocturnal continuous positive airway pressure (CPAP) therapy. The aim of this study...
Wed Jun 03, 2020 14:17
Related ArticlesCardiometabolic Benefits of a Weight-Loss Mediterranean Diet/Lifestyle Intervention in Patients with Obstructive Sleep Apnea: The "MIMOSA" Randomized Clinical Trial. Nutrients. 2020 May 28;12(6): Authors: Georgoulis M, Yiannakouris N, Kechribari I, Lamprou K, Perraki E, Vagiakis E, Kontogianni MD Abstract Although continuous positive airway pressure (CPAP) is the first-line treatment for obstructive sleep apnea (OSA), its cardiometabolic...
Wed Jun 03, 2020 14:17
Related ArticlesLetter to the Editor from Melanson et al (second letter): Twice as High Diet-Induced Thermogenesis After Breakfast vs Dinner on High-Calorie as Well as Low-Calorie Meals. J Clin Endocrinol Metab. 2020 Jun 02;: Authors: Melanson EL, Chen KY PMID: 32485743 [PubMed - as supplied by publisher]
Wed Jun 03, 2020 18:18
Related ArticlesLetter to the Editor from Malek et al: Trends in Endocrinology Fellowship Recruitment: Reasons for Concern and Possible Interventions. J Clin Endocrinol Metab. 2020 Jun 02;: Authors: Malek R, Lamos EM PMID: 32485742 [PubMed - as supplied by publisher]
Wed Jun 03, 2020 18:18
Related ArticlesResponse to Letter to the Editor from Melanson et al (second letter): Twice as high diet-induced thermogenesis after breakfast vs dinner on high-calorie as well as low-calorie meals. J Clin Endocrinol Metab. 2020 Jun 02;: Authors: Richter J, Oltmanns KM PMID: 32485741 [PubMed - as supplied by publisher]
Wed Jun 03, 2020 18:18
Related ArticlesResponse to Letter to the Editor from Malek R: Trends in Endocrinology Fellowship Recruitment: Reasons for Concern and Possible Interventions. J Clin Endocrinol Metab. 2020 Jun 02;: Authors: Romeo GR, Hirsch IB, Lash RW, Gabbay RA PMID: 32485740 [PubMed - as supplied by publisher]
Wed Jun 03, 2020 18:18
Related ArticlesGLP-1 receptor agonist as adjuvant therapy in type 1 diabetes: No apparent benefit for beta cell function or glycemia. J Clin Endocrinol Metab. 2020 Jun 02;: Authors: Redondo MJ, Bacha F PMID: 32485735 [PubMed - as supplied by publisher]
Wed Jun 03, 2020 18:18
Related ArticlesCardiovascular (CV) Benefit of Empagliflozin Across the Spectrum of CV Risk Factor Control in the EMPA-REG OUTCOME Trial. J Clin Endocrinol Metab. 2020 Jun 02;: Authors: Inzucchi SE, Khunti K, Fitchett DH, Wanner C, Mattheus M, George JT, Ofstad AP, Zinman B Abstract CONTEXT: Control of multiple cardiovascular (CV) risk factors reduces CV events in individuals with type 2 diabetes (T2D). OBJECTIVE: To investigate this association...
Wed Jun 03, 2020 18:18
Related ArticlesVery-Low-Calorie Ketogenic Diets with Whey, Vegetable or Animal Protein in Patients with Obesity: A Randomized Pilot Study. J Clin Endocrinol Metab. 2020 Jun 02;: Authors: Basciani S, Camajani E, Contini S, Persichetti A, Risi R, Bertoldi L, Strigari L, Prossomariti G, Watanabe M, Mariani S, Lubrano C, Genco A, Spera G, Gnessi L Abstract CONTEXT: We compared the efficacy, safety and effect of 45-day isocaloric very-low-calorie ketogenic...
Wed Jun 03, 2020 18:18
Related ArticlesNetwork-Based Transcriptome-Wide Expression Study for Postmenopausal Osteoporosis. J Clin Endocrinol Metab. 2020 Jun 01;: Authors: Zhang L, Peng TL, Wang L, Meng XH, Zhu W, Zeng Y, Zhu JQ, Zhou Y, Xiao HM, Deng HW Abstract PURPOSE: As a crucial physiological transition during the women's life, menopause occurs with growing risks of health issues like osteoporosis. To identify postmenopausal osteoporosis-related genes, we performed transcriptome-wide...
Wed Jun 03, 2020 14:15
L'articolo Editorial – Sofosbuvir/Velpatasvir as a combination with strong potential activity against SARS-CoV2 (COVID-19) infection: how to use direct-acting antivirals as broad-spectrum antiviral agents sembra essere il primo su European Review.
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Nature Communications, Published online: 03 June 2020; doi:10.1038/s41467-020-16595-wSequestration of reactants in lipid vesicles is a strategy prevalent in biological systems to raise the rate and specificity of chemical reactions. Here, the authors show that micelle-assisted reactions facilitate native chemical ligation between a peptide-thioester and a Cys-peptide modified by a lipid-like moiety.
Wed Jun 03, 2020 03:00
Nature Communications, Published online: 03 June 2020; doi:10.1038/s41467-020-16576-zBlack carbon is a recalcitrant and unique form of organic carbon formed from incomplete combustion. Here the authors use global sampling to reduce uncertainty in the flux of terrestrial black carbon to the oceans, predicting that 34% of black carbon produced by fires has an oceanic fate.
Wed Jun 03, 2020 03:00
Nature Communications, Published online: 03 June 2020; doi:10.1038/s41467-020-16592-zGenetic variants at the RSPO3 locus are associated with waist-to-hip ratio (adjusted for BMI). Here, Loh et al. describe two independent RSPO3 signals that associate with body fat distribution, perform fine-mapping and explore the function of RSPO3 in human adipocyte biology and body fat distribution in zebrafish
Wed Jun 03, 2020 03:00
Nature Communications, Published online: 03 June 2020; doi:10.1038/s41467-020-16538-5Publisher Correction: MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer
Wed Jun 03, 2020 03:00
Nature Communications, Published online: 03 June 2020; doi:10.1038/s41467-020-16651-5Mediator is a multiprotein complex required to activate gene transcription by RNAPII. Here, the authors report that MED12 and MED13 are conditional positive regulators that facilitate the expression of genes depleted in active chromatin marks and the induction of gene expression in response to environmental stimuli in Arabidopsis.
Wed Jun 03, 2020 03:00
Nature Communications, Published online: 03 June 2020; doi:10.1038/s41467-020-16468-2Author Correction: The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition
Wed Jun 03, 2020 03:00
Nature Communications, Published online: 03 June 2020; doi:10.1038/s41467-020-16609-7The orbitofrontal cortex (OFC) encodes expected outcomes and plays a key role in outcome-guided behavior. The authors show here that the top-down projection from the OFC to the visual cortex drives visual associative learning by modulating the response gain of V1 neurons to non-relevant stimuli.
Wed Jun 03, 2020 03:00
Nature Communications, Published online: 03 June 2020; doi:10.1038/s41467-020-16555-4Previous study identified in vivo structured mRNA regions in Saccharomyces cerevisiae by dimethyl sulfate-sequencing. Here the authors use quantitative proteomics to identify protein interactors of 186 RNA folds in S. cerevisiae, providing functional links between RNA binding proteins and distinct mRNA fold.
Wed Jun 03, 2020 03:00
Abstract Purpose To evaluate the feasibility and safety of endovascular recanalization for symptomatic subacute and chronic internal carotid artery occlusion (ICAO); to propose a newly modified radiographic classification of ICAO that can rigorously identify suitable candidates for endovascular ICAO treatment. Methods We included 42 consecutive patients...
Wed Jun 03, 2020 03:00
Related ArticlesModulation of Mutational Landscape in HER2-Positive Breast Cancer after Neoadjuvant Chemotherapy. Transl Oncol. 2020 May 30;13(9):100794 Authors: Omarini C, Bettelli S, Manfredini S, Barbolini M, Isca C, Cortesi G, Maiorana A, Tazzioli G, Dominici M, Piacentini F Abstract INTRODUCTION: In early-stage HER2 positive breast cancer (BC) patients, tumor response to neoadjuvant chemotherapy (NACT) predict survival outcomes. Patients achieving...
Wed Jun 03, 2020 18:04
Related ArticlesMultifunctional Complexes Based on Photoluminescent Upconversion Nanoparticles for Theranostics of the HER2-Positive Tumors. Dokl Biochem Biophys. 2020 Mar;491(1):73-76 Authors: Guryev EL, Smyshlyaeva AS, Shilyagina NY, Shanwar S, Kostyuk AB, Shulga AA, Konovalova EV, Zvyagin AV, Deyev SM, Petrov RV Abstract Combining diagnostic and therapeutic functions in one agent is a promising strategy in the development of personalized approaches...
Wed Jun 03, 2020 14:02
Related ArticlesSerum PD-1/PD-L1 Levels, Tumor Expression and PD-L1 Somatic Mutations in HER2-Positive and Triple Negative Normal-Like Feline Mammary Carcinoma Subtypes. Cancers (Basel). 2020 May 28;12(6): Authors: Nascimento C, Urbano AC, Gameiro A, Ferreira J, Correia J, Ferreira F Abstract Tumor microenvironment has gained great relevance due to its ability to regulate distinct checkpoints mediators, orchestrating tumor progression. Serum programmed...
Wed Jun 03, 2020 14:02
Related ArticlesHigh Parasitic Contamination of Soil Samples in the North of Iran: a Potential Risk of Parasitic Infection for Tourists. Infect Disord Drug Targets. 2020 Jun 02;: Authors: Haghparast-Kenari B, Nayeri T, Sarvi S, Rahimi MT, Ahmadpour E, Sharif M, Daryani A Abstract BACKGROUND: Soil-transmitted parasites (STPs) are significant intestinal parasites that infect humans and animals and impose considerable burdens on human society and animal...
Wed Jun 03, 2020 18:01
Related ArticlesDisseminated TB in an Immunocompetent Patient: A Case Report. Infect Disord Drug Targets. 2020 May 28;: Authors: Nezhad MH, Ganadan A, Alinaghi SAS, Abadi FNA, Manshadi SAD, Salehi MR, Ghiasvand F, Khatami SR Abstract Tuberculosis considered as a chronic infectious disease caused by Mycobacterium tuberculosis, may invade all organs but mainly affects the lungs [1].In overall, disseminated TB is rare in immunocompetent patients and its...
Wed Jun 03, 2020 18:01
Related ArticlesEvaluation of type II toxin-antitoxin systems, antibiotic resistance profiles, and biofilm quorum sensing genes in Acinetobacter baumannii isolates in Iraq. Infect Disord Drug Targets. 2020 May 25;: Authors: Al Marjania MF, Kouhsari E, Ali FS, Authman SH Abstract BACKGROUND: Bacterial Toxin-Antitoxin (TAs) systems are extensive two-component elements in the bacterial genome, which involved in many key biological functions including growth...
Wed Jun 03, 2020 18:01
Related ArticlesUltrapulsed CO2 ablation in the treatment of Xanthelasma Palpebrarum: high satisfaction treatment with low recurrence. J Dermatolog Treat. 2020 Jun 02;:1-10 Authors: Al-Niaimi F Abstract Xanthelasma are localised accumulation of lipid deposits on the eyelids. Lesions are typically asymptomatic and treatment is often sought for cosmetic purposes. Unfortunately, there is paucity of strong evidence in the literature for the effective treatment...
Wed Jun 03, 2020 17:59
Related ArticlesCancer stem cells, epigenetics, tumor microenvironment and future therapeutics in cutaneous malignant melanoma: a review. Future Oncol. 2020 Jun 02;: Authors: Kyriakou G, Melachrinou M Abstract This review provides an overview of the current understanding of the ontogeny and biology of melanoma stem cells in cutaneous malignant melanoma. This article also summarizes and evaluates the current knowledge of the underlying epigenetic mechanisms,...
Wed Jun 03, 2020 17:58
Related ArticlesEvaluation of relationship between SPON1 gene and genetic susceptibility of postmenopausal osteoporosis. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):818-823 Authors: Ma W, Chen K, Xiao W, Tang H, Wang S, Wang K Abstract Purpose: Postmenopausal osteoporosis (PMOP) is one of systemic bone degenerative diseases characterised by decreased bone mineral density (BMD). Previous studies suggest that the SPON1 gene may be associated with...
Wed Jun 03, 2020 14:48
Related ArticlesAvian gut experiments: an alternative approach for teaching the properties of intestinal smooth muscles. Adv Physiol Educ. 2020 Sep 01;44(3):295-304 Authors: Pant J, Mohan L, S S Abstract Experiments on isolated mammalian gut are essential components of the physiology curriculum worldwide. Over the years, these routine experiments have been largely replaced by simulation modules, to reduce the euthanization of animals for understanding...
Wed Jun 03, 2020 19:46
Related ArticlesKnowledge gains in a professional development workshop on diversity, equity, inclusion, and implicit bias in academia. Adv Physiol Educ. 2020 Sep 01;44(3):286-294 Authors: Harrison-Bernard LM, Augustus-Wallace AC, Souza-Smith FM, Tsien F, Casey GP, Gunaldo TP Abstract As literature indicates, historic racism and implicit bias throughout academia have been profound metrics leading to a lack of diversity, as related to people from underrepresented...
Wed Jun 03, 2020 19:46
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