Related ArticlesRelapsed Osteosarcoma Trial Concepts to Match the Complexity of the Disease. Adv Exp Med Biol. 2020;1257:85-94 Authors: Reed DR, Hingorani P, Anderson PM Abstract Osteosarcoma relapses not only herald a very poor prognosis but also opportunities to treat this genetically diverse complex cancer in new ways. This review will attempt to show that the field is a rapidly evolving one in which not only cytotoxic agents but also local control...
Wed Jun 03, 2020 13:11
Related ArticlesFormulation and Delivery Technologies for mRNA Vaccines. Curr Top Microbiol Immunol. 2020 Jun 02;: Authors: Zeng C, Zhang C, Walker PG, Dong Y Abstract mRNA vaccines have become a versatile technology for the prevention of infectious diseases and the treatment of cancers. In the vaccination process, mRNA formulation and delivery strategies facilitate effective expression and presentation of antigens, and immune stimulation. mRNA vaccines...
Wed Jun 03, 2020 13:11
Related ArticlesRapid conjugation of antibodies to toxins to select candidates for the development of anticancer Antibody-Drug Conjugates (ADCs). Sci Rep. 2020 Jun 01;10(1):8869 Authors: Hoffmann RM, Mele S, Cheung A, Larcombe-Young D, Bucaite G, Sachouli E, Zlatareva I, Morad HOJ, Marlow R, McDonnell JM, Figini M, Lacy KE, Tutt AJN, Spicer JF, Thurston DE, Karagiannis SN, Crescioli S Abstract Antibody-Drug Conjugates (ADCs) developed as a targeted treatment...
Wed Jun 03, 2020 13:11
Related ArticlesPNO1, which is negatively regulated by miR-340-5p, promotes lung adenocarcinoma progression through Notch signaling pathway. Oncogenesis. 2020 Jun 01;9(5):58 Authors: Liu D, Lin L, Wang Y, Chen L, He Y, Luo Y, Qi L, Guo Y, Chen L, Han Z, Li G, Li Q, Liu Z, Chen P, Guo H Abstract Many studies have shown that the hyperactivation of ribosome biogenesis plays essential roles in the initiation and progression of cancers. As a ribosome assembly...
Wed Jun 03, 2020 13:11
Related ArticlesHigh-Risk Adenomas at Screening Colonoscopy Remain Predictive of Future High-Risk Adenomas Despite an Intervening Negative Colonoscopy. Am J Gastroenterol. 2020 May 28;: Authors: Sullivan BA, Redding TS, Hauser ER, Gellad ZF, Qin X, Gupta S, Robertson DJ, Weiss DG, OʼLeary MC, Madison AN, Sims KJ, Williams CD, Hong JC, Lieberman D, Provenzale D Abstract INTRODUCTION: Limited data inform the current postpolypectomy surveillance guidelines,...
Wed Jun 03, 2020 13:11
Related ArticlesBridging the Translational Divide in Oncology: In Vivo Testing of Chemo-Sensitivity. Clin Cancer Res. 2020 Jun 01;: Authors: Sleijfer S, Lolkema M Abstract A study was presented in which sarcomas were microinjected simultaneously with several drugs to study the pharmacodynamic response after resection. This platform may represent a future way of probing efficacy of anticancer agents in the relevant model system: human tumors.PMID: 32482905...
Wed Jun 03, 2020 13:11
Related ArticlesConsistent Biopsy Quality and Gleason Grading Within the Global Active Surveillance Global Action Plan 3 Initiative: A Prerequisite for Future Studies. Eur Urol Oncol. 2019 05;2(3):333-336 Authors: van der Kwast TH, Helleman J, Nieboer D, Bruinsma SM, Roobol MJ, Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance (GAP3) Consortium, Trock B, Ehdaie B, Carroll P, Filson C, Kim J, Logothetis C, Morgan T, Klotz L, Pickles T, Hyndman...
Wed Jun 03, 2020 13:11
A retrospective case series of radiologically or microbiologically confirmed cases of bacterial sternoclavicular joint (SCJ) septic arthritis at Fiona Stanley Hospital was analysed. SCJ septic arthritis can be primarily treated medically in most cases without acutely life‐threatening complications. Need for surgical resection of the SCJ and medial third of the clavicle may be less than previously reported. Abstract Background Sternoclavicular joint septic arthritis (SCJ SA) is a rare infectious...
Tue Jun 02, 2020 22:54
This study of a complete national cohort of children diagnosed with Hirschsprung disease (HD) and followed for a median of more than 7 years highlights the contemporary management of HD. Most New Zealand born infants with short‐segment HD are currently managed by primary pull‐through, usually in the first months of life. Abstract Background The aim of this study was to report the contemporary management of Hirschsprung disease (HD) in New Zealand. Methods We undertook a national multi‐centre...
Tue Jun 02, 2020 22:42
Tue Jun 02, 2020 22:19
Tendinous mallet finger deformity can be treated by reconstructing extensor tendon insertion, and it is realized by suturing the transferred portion of flexor digitorum profundus tendon with the ruptured extensor tendon via the constructed bone tunnel. Abstract Background To introduce and evaluate an updated surgical technique for the treatment of tendinous mallet finger deformity. Methods From April 2017 to September 2018, 13 cases of tendinous mallet finger deformity were treated....
Tue Jun 02, 2020 11:15
The aim of this study was to determine the surgeon‐modifiable factors which impact the rates of post‐operative complications following parotidectomy for benign pathology. Focused tumour dissection, nerve integrity monitoring and dermofat grafting are surgeon‐modifiable variables associated with lower rates of post‐operative complications following parotidectomy for benign pathology. However, the benefit of these operative techniques relies on their appropriate utilization by performing surgeons....
Tue Jun 02, 2020 11:03
The objectives of this study were to perform a cost‐analysis of admissions following gastrectomy for gastric carcinoma. The presence and severity of post‐operative complications is strongly associated with increasing cost. Minimizing complications, in addition to obvious clinical benefits, enables a large reduction in costs of care. Abstract Background The management of post‐gastrectomy complications requires considerable resources and is likely associated with a substantial economic burden....
Tue Jun 02, 2020 11:02
Abstract Biologic medications are emerging as options for treating chronic rhinosinusitis with nasal polyps. Several questions remain regarding patient selection, indications, clinical efficacy and cost effectiveness. In November of 2019, a group of physicians and scientists gathered to consider strategies for future studies regarding biologics. During the discussion, gaps in knowledge highlighted a need for a consensus on the present day use of biologics in polyp patients. The goal of this guideline...
Tue Jun 02, 2020 18:02
Assessing the proximal esophageal segment on HREM may be useful in characterizing patients with esophageal symptoms. Abnormal PCI was found in a fourth of patients with esophageal symptoms. PCI may be useful to distinguish some esophageal motility disorders. Patients with abnormal PCI had a higher severity of some upper gastrointestinal symptoms than patients with normal PCI. Abstract Background Proximal esophageal striated muscle contractility may be abnormal in patients with esophageal symptoms,...
Tue Jun 02, 2020 14:43
Objectives/Hypothesis To determine the improvement in word recognition score (WRS65) after cochlear implant (CI) surgery in hearing aid (HA) users with preoperative hearing threshold ≤80 dB HL and inadequate speech recognition scores with HA. Secondarily, to identify predictive factors for WRS65 with a CI (WRS65[CI]) 6 months after surgery, derived from the standard German CI preoperative assessment. Study Design Retrospective chart review. Methods Retrospective review of all adult...
Tue Jun 02, 2020 22:04
Tue Jun 02, 2020 22:03
Tue Jun 02, 2020 22:03
Tue Jun 02, 2020 22:03
Shared decision-making (SDM) is a patient-centered process in medicine which allows for a patient and their clinician to entertain a mutual discussion regarding care or treatment options, whereby the patient’s values and preferences are explored and defined to help find the best option for that patient.1,2 SDM is an extension of the concept of patient-centered care, which was more formally characterized in a 2001 Institute of Medicine report. As part of this report, SDM was defined as a process that...
Wed Jun 03, 2020 03:00
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo investigate the manifestations and incidence of headaches caused by heroin in Chinese women.MethodsThis was a survey study conducted from 29 June to 3 July 2015 with women attending the Shanxi Drug Rehabilitation Centre for Women (China). All study subjects were newly admitted and had not begun their drug rehabilitation. Demographic characteristics, heroin usage and headache episodes within the previous 3 months...
Wed Jun 03, 2020 12:05
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectivesMigration of macrophages and atherosclerosis result in various diseases, including coronary heart disease. This study aimed to clarify the roles that ghrelin and Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) play in migration of macrophages under chronic intermittent hypoxia (CIH).MethodsA rat model of CIH was constructed and changes in ghrelin and ROCK2 protein expression were measured by western...
Tue Jun 02, 2020 14:59
Netrin-1 reduces lung ischemia-reperfusion injury by increasing the proportion of regulatory T cells
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveInflammation is the primary mechanism of lung ischemia-reperfusion injury (LIRI) and neurologic factors can regulate inflammatory immune responses. Netrin-1 is an axonal guidance molecule, but whether Netrin-1 plays a role in LIRI remains unclear.MethodsA mouse model of LIRI was established. Immunohistochemistry was used to detect expression of Netrin-1 and to enumerate macrophages and T cells in lung tissue. The proportion...
Tue Jun 02, 2020 14:57
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo assess the effects of a single dose of vitamin D on 25-hydroxyvitamin D (25OHD) levels and clinical outcomes in children with vitamin D deficiency (VDD) and sepsis.MethodsIn this randomized, controlled trial, eligible children with VDD and sepsis were assigned to receive one dose of 150,000 IU of cholecalciferol or placebo. Serum concentrations of 25OHD, angiotensin-II (Ang-II), interleukin-6 (IL-6), and tumor necrosis...
Tue Jun 02, 2020 14:55
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Intravascular large B-cell lymphoma (IVLBCL) is a rare (<1%), typically aggressive extranodal variant of mature non-Hodgkin B-cell lymphoma. IVLBCL is characterized by malignant lymphoid cells lodged within blood vessels, particularly capillary channels. Herein, we present a case of a 50-year-old man with a history of myeloradiculitis (∼1 year) and paraparesis requiring hospitalization. During the course of his hospital...
Tue Jun 02, 2020 14:51
Journal of International Medical Research, Volume 48, Issue 6, June 2020. BackgroundA novel technique of continuous transversus abdominis plane block (TAPB) has been reported to be beneficial to patients undergoing abdominal surgery because it can significantly relieve postoperative pain. The aim of our study is to compare this novel technique with a traditional technique of continuous epidural analgesia (EA).MethodsWe conducted our meta-analysis in accordance with Preferred Reporting Items for Systematic...
Tue Jun 02, 2020 14:50
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Patients with ovarian cancer are often in a hypercoagulable state and have a high risk of venous thrombosis, including deep vein thrombosis and pulmonary embolism. However, arterial thrombosis is relatively rare in ovarian cancer. We report a case a 46-year-old woman with ovarian clear cell carcinoma who developed arterial and venous thrombosis in the lower extremities as the first manifestation. Her arterial thrombosis-related...
Tue Jun 02, 2020 14:46
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo evaluate the impact of an enhanced recovery after surgery (ERAS) pathway on patients undergoing minimally invasive radical prostatectomy at a single institute.MethodsIn this retrospective study, 301 patients who underwent laparoscopic or robot-assisted laparoscopic radical prostatectomy from May 2014 to September 2018 were consecutively recruited. Before April 2017, the patients were treated with conventional care;...
Tue Jun 02, 2020 14:45
Journal of International Medical Research, Volume 48, Issue 6, June 2020. This study was performed to describe the clinical features, risk factors, and treatment methods of uterine torsion in pregnancy. The most common symptoms are abdominal pain, fetal heart rate changes, and failure of cervical dilatation and are often accompanied by complete or partial placental abruption. Preoperative diagnosis is challenging even with the use of ultrasound. Uterine torsion in the third trimester is correlated...
Tue Jun 02, 2020 14:44
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveMany studies have shown that the C1562T polymorphism in the matrix metalloproteinase (MMP)-9 gene promoter is associated with susceptibility to ischemic stroke (IS), but the association between them remains controversial. Our objective was to explore the relationship between MMP9 C1562T polymorphism and susceptibility to IS in the Chinese population.MethodsWe conducted a database search of Wanfang, China Science and...
Tue Jun 02, 2020 14:41
Abstract Pathologic extranodal extension (pENE) impacts treatment planning and is an important prognostic indicator for patients with head and neck squamous cell carcinoma (HNSCC). Computed tomography (CT) is a commonly used modality for assessment of radiographic ENE (rENE). To determine the predictive value of CT‐identified rENE in predicting pENE, we performed a systematic review through a search of 4 databases (PubMed, Scopus, Cochrane, and OVID). Meta‐analysis of diagnostic performance based...
Tue Jun 02, 2020 16:14
Abstract Background We report outcomes for patients with T2N0M0 glottic squamous cell carcinoma (SCC) treated with radiation therapy (RT). Methods Patients who received definitive RT for T2 glottic SCC from 2000 through 2013 were retrospectively reviewed. Results One hundred and thirteen patients were analyzed (median follow‐up time 91 months; 85 patients received three‐dimensional conformal radiotherapy [3D‐CRT] and 28 received intensity‐modulated radiation therapy [IMRT]). Fractionation...
Tue Jun 02, 2020 15:35
On May 1, 2020, we published "Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19," a study of the effect of preexisting treatment with angiotensin-converting enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) on Covid-19. This retrospective study used data drawn from an…
Tue Jun 02, 2020 03:00
Abstract Epidermolysis bullosa (EB) is a heritable blistering disorder. We performed a next‐generation sequencing‐based multi‐gene panel test and successfully predicted 100% of the EB types, including 36舁EB simplex (EBS), 13 junctional EB (JEB), 86 dystrophic EB (DEB), and 3 Kindler EB (KEB). Chinese JEB and recessive DEB (RDEB) patients have relatively mild phenotypes; for severe type separately accounts for 45.5% and 23.8%, respectively. We identified 96 novel and 49 recurrent pathogenic...
Tue Jun 02, 2020 13:07
Abstract Apical periodontitis (AP) is a prevalent infectious and inflammatory disorder that involves inflammation of periapical tissues and the disintegration of alveolar bone. AP may eventually lead to tooth loss if not timely treated. This disease is caused by pathogenic bacteria in the necrotic pulps and root canals thereby triggering responses from the innate and adaptive immune system of the periapical tissues. Regulatory T (Treg) cells play a major role in maintaining immune homeostasis and...
Tue Jun 02, 2020 11:29
Abstract Circadian disruption may play a role in breast carcinogenesis. Previous studies reported relationships between outdoor light at night (LAN) and the breast cancer risk, but their findings are mixed. There is also a need to examine LAN and breast cancer incidence according to different individual and environmental characteristics to identify subpopulations at greater risk associated with LAN exposure. We studied residential outdoor LAN estimated from satellite imagery at baseline (1996) in...
Tue Jun 02, 2020 20:01
Abstract Australia’s new HPV‐based cervical screening program is based on an algorithm that incorporates reflex cytology to guide decisions about further follow‐up with colposcopy and, if indicated, biopsy. We reviewed results for 2300 women referred directly for colposcopy following their first positive HPV screening test, to determine the proportion that had underlying histological high‐grade abnormality (HGA). Overall, HGA was detected in 24.3% of women. Among HPV16/18 positive women, 18.0% had...
Tue Jun 02, 2020 13:56
In mammography screening programmes, women are screened according to a one‐size‐fits‐all principle. Tailored screening, based on risk levels, may lead to a better balance of benefits and harms. With microsimulation modelling, we determined optimal mammography screening strategies for women at lower (relative risk [RR]0.75) and higher (RR1.8) than average risk of breast cancer, eligible for screening, using the incremental cost‐effectiveness ratio (ICER) of current uniform screening in the Netherlands...
Tue Jun 02, 2020 13:36
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