Antibiotics, Vol. 9, Pages 299: Exploring the Socioeconomic Importance of Antimicrobial Use in the Small-Scale Pig Sector in Vietnam Antibiotics doi: 10.3390/antibiotics9060299 Authors: Coyne Beningo Giang Huong Kalprividh Padungtod Patrick Ngoc Rushton Antimicrobial resistance (AMR) is influenced by antimicrobial use in human and animal health. This use exerts selection pressure on pathogen populations with the development of resistance and the exchange...
Wed Jun 03, 2020 03:00
Antioxidants, Vol. 9, Pages 485: Ethosomes for Coenzyme Q10 Cutaneous Administration: From Design to 3D Skin Tissue Evaluation Antioxidants doi: 10.3390/antiox9060485 Authors: Maddalena Sguizzato Paolo Mariani Francesco Spinozzi Mascia Benedusi Franco Cervellati Rita Cortesi Markus Drechsler Roxane Prieux Giuseppe Valacchi Elisabetta Esposito Ethosome represents a smart transdermal vehicle suitable for solubilization and cutaneous application of drugs. Coenzyme...
Wed Jun 03, 2020 03:00
Antioxidants, Vol. 9, Pages 486: Ex Vivo and In Vivo Assessment of the Penetration of Topically Applied Anthocyanins Utilizing ATR-FTIR/PLS Regression Models and HPLC-PDA-MS Antioxidants doi: 10.3390/antiox9060486 Authors: Alexandra Westfall Gregory T. Sigurdson Luis E. Rodriguez-Saona M. Mónica Giusti Anthocyanins are natural colorants with antioxidant properties, shown to inhibit photoaging reactions and reduce symptoms of some skin diseases. However, little is known about...
Wed Jun 03, 2020 03:00
Antioxidants, Vol. 9, Pages 487: Ocular and Systemic Effects of Antioxidative Supplement Use in Young and Healthy Adults: Real-World Cross-Sectional Data Antioxidants doi: 10.3390/antiox9060487 Authors: Minami Nagai Suzuki Uchida Shinoda Tsubota Ozawa Randomized controlled studies have shown that antioxidative supplements are effective in suppressing the progression of age-related macular degeneration and visual display terminal syndrome. However, effects of...
Wed Jun 03, 2020 03:00
Antioxidants, Vol. 9, Pages 482: Thymus zygis subsp. zygis an Endemic Portuguese Plant: Phytochemical Profiling, Antioxidant, Anti-Proliferative and Anti-Inflammatory Activities Antioxidants doi: 10.3390/antiox9060482 Authors: Amélia M. Silva Carlos Martins-Gomes Eliana B. Souto Judith Schäfer João A. Santos Mirko Bunzel Fernando M. Nunes Thymus zygis subsp. zygis is an endemic Portuguese plant belonging to the Thymus zygis species. Although T. zygis is commonly used...
Wed Jun 03, 2020 03:00
Antioxidants, Vol. 9, Pages 484: Extraction and Analysis by HPLC-DAD of Carotenoids in Human Faeces from Spanish Adults Antioxidants doi: 10.3390/antiox9060484 Authors: Rodríguez-Rodríguez Beltrán-de-Miguel Samaniego-Aguilar Sánchez-Prieto Estévez-Santiago Olmedilla-Alonso Carotenoids are bioactive compounds with widely accepted health benefits. Their quantification in human faeces can be a useful non-invasive approach to assess their bioavailability. Identification...
Wed Jun 03, 2020 03:00
Antioxidants, Vol. 9, Pages 481: Oxidative Stress in Plants Antioxidants doi: 10.3390/antiox9060481 Authors: Mounira Chaki Juan C. Begara-Morales Juan B. Barroso Environmental stresses negatively affect plant growth, development and crop productivity [...]
Wed Jun 03, 2020 03:00
Antioxidants, Vol. 9, Pages 483: A Mixture of Algae and Extra Virgin Olive Oils Attenuates the Cardiometabolic Alterations Associated with Aging in Male Wistar Rats Antioxidants doi: 10.3390/antiox9060483 Authors: González-Hedström Amor de la Fuente-Fernández Tejera-Muñoz Priego Martín López-Calderón Inarejos-García García-Villalón Granado Aging is one of the major risk factors for suffering cardiovascular and metabolic diseases. Due to the increase...
Wed Jun 03, 2020 03:00
Atmosphere, Vol. 11, Pages 590: Saharan Hot and Dry Sirocco Winds Drive Extreme Fire Events in Mediterranean Tunisia (North Africa) Atmosphere doi: 10.3390/atmos11060590 Authors: Belhadj-Khedher El-Melki Mouillot With hot and dry summers, the Mediterranean basin is affected by recurrent fires. While drought is the major driver of the seasonal and inter-annual fire distribution in its northern and mildest climate conditions, some extreme fire events are also linked to extreme...
Wed Jun 03, 2020 03:00
Atmosphere, Vol. 11, Pages 586: Stratosphere–Troposphere Exchange and O3 Variability in the Lower Stratosphere and Upper Troposphere over the Irene SHADOZ Site, South Africa Atmosphere doi: 10.3390/atmos11060586 Authors: Mkololo Mbatha Sivakumar Bègue Coetzee Labuschagne This study aims to investigate the Stratosphere-Troposphere Exchange (STE) events and ozone changes over Irene (25.5°S, 28.1°E). Twelve years of ozonesondes data (2000–2007,...
Wed Jun 03, 2020 03:00
Atmosphere, Vol. 11, Pages 589: Relative Risk Functions for Estimating Excess Mortality Attributable to Outdoor PM2.5 Air Pollution: Evolution and State-of-the-Art Atmosphere doi: 10.3390/atmos11060589 Authors: Richard Burnett Aaron Cohen The recent proliferation of cohort studies of long-term exposure to outdoor fine particulate air pollution and mortality has led to a significant increase in knowledge about this important global health risk factor. As scientific knowledge has grown,...
Wed Jun 03, 2020 03:00
Atmosphere, Vol. 11, Pages 588: Impacts of Tree Canopy Cover on Microclimate and Human Thermal Comfort in a Shallow Street Canyon in Wuhan, China Atmosphere doi: 10.3390/atmos11060588 Authors: Huang Wu Teng Lin Increasing the number of street trees can be a promising method to reduce impacts of climate change currently impacting urban public health. However, the quantitative relationships between tree canopy cover and thermal comfort remains unclear, particularly in areas...
Wed Jun 03, 2020 03:00
Atmosphere, Vol. 11, Pages 587: Projection of Future Heat Waves in the United States. Part I: Selecting a Climate Model Subset Atmosphere doi: 10.3390/atmos11060587 Authors: Shafiei Shiva G. Chandler The widespread increase in global temperature is driving more frequent and more severe local heatwaves within the contiguous United States (CONUS). General circulation models (GCMs) show increasing, but spatially uneven trends in heatwave properties. However, the wide range of model...
Wed Jun 03, 2020 03:00
Atmosphere, Vol. 11, Pages 585: Temporal Hydrological Drought Index Forecasting for New South Wales, Australia Using Machine Learning Approaches Atmosphere doi: 10.3390/atmos11060585 Authors: Abhirup Dikshit Biswajeet Pradhan Abdullah M. Alamri Droughts can cause significant damage to agriculture and water resources leading to severe economic losses. One of the most important aspects of drought management is to develop useful tools to forecast drought events, which could be helpful...
Wed Jun 03, 2020 03:00
Bioengineering, Vol. 7, Pages 50: Multivariate Monitoring Workflow for Formulation, Fill and Finish Processes Bioengineering doi: 10.3390/bioengineering7020050 Authors: Barbara Pretzner Christopher Taylor Filip Dorozinski Michael Dekner Andreas Liebminger Christoph Herwig Process monitoring is a critical task in ensuring the consistent quality of the final drug product in biopharmaceutical formulation, fill, and finish (FFF) processes. Data generated during FFF monitoring...
Wed Jun 03, 2020 03:00
Biology, Vol. 9, Pages 117: Hydralazine Sensitizes to the Antifibrotic Effect of 5-Aza-2′-deoxycytidine in Hepatic Stellate Cells Biology doi: 10.3390/biology9060117 Authors: Kiyoshi Asada Kosuke Kaji Shinya Sato Kenichiro Seki Naotaka Shimozato Hideto Kawaratani Hiroaki Takaya Yasuhiko Sawada Keisuke Nakanishi Masanori Furukawa Mitsuteru Kitade Kei Moriya Tadashi Namisaki Ryuichi Noguchi Takemi Akahane Hitoshi Yoshiji Background: Hepatic...
Wed Jun 03, 2020 03:00
Biomolecules, Vol. 10, Pages 853: Oenological Characteristics of Fermented Apple Musts and Volatile Profile of Brandies Obtained from Different Apple Cultivars Biomolecules doi: 10.3390/biom10060853 Authors: Magdalena Januszek Paweł Satora Tomasz Tarko Volatile profile of spirits is the most important factor, because it can contribute to pleasant flavor. The aim of the study was to determine the impact of dessert apple cultivar used for fermentation on the concentration of volatile...
Wed Jun 03, 2020 03:00
Biomolecules, Vol. 10, Pages 851: Subtilisin-Involved Morphology Engineering for Improved Antibiotic Production in Actinomycetes Biomolecules doi: 10.3390/biom10060851 Authors: Yuanting Wu Qianjin Kang Li-Li Zhang Linquan Bai In the submerged cultivation of filamentous microbes, including actinomycetes, complex morphology is one of the critical process features for the production of secondary metabolites. Ansamitocin P-3 (AP-3), an antitumor agent, is a secondary metabolite...
Wed Jun 03, 2020 03:00
Biomolecules, Vol. 10, Pages 852: Acetylcholine and Acetylcholine Receptors: Textbook Knowledge and New Data Biomolecules doi: 10.3390/biom10060852 Authors: Tsetlin It was a pleasure to receive a proposal to organize and be a guest editor of a Special Issue ofBiomolecules. This is the field in which I am working and personally know some of the leadingscientists. My narrow field is the research on the peptide and protein neurotoxins from animalvenoms and their application as sophisticated...
Wed Jun 03, 2020 03:00
Biomolecules, Vol. 10, Pages 854: Metallo-β-Lactamase Inhibitors Inspired on Snapshots from the Catalytic Mechanism Biomolecules doi: 10.3390/biom10060854 Authors: Antonella R. Palacios María-Agustina Rossi Graciela S. Mahler Alejandro J. Vila β-Lactam antibiotics are the most widely prescribed antibacterial drugs due to their low toxicity and broad spectrum. Their action is counteracted by different resistance mechanisms developed by bacteria. Among them, the most...
Wed Jun 03, 2020 03:00
Biomolecules, Vol. 10, Pages 850: Can We Assume the Gene Expression Profile as a Proxy for Signaling Network Activity? Biomolecules doi: 10.3390/biom10060850 Authors: Mehran Piran Reza Karbalaei Mehrdad Piran Jehad Aldahdooh Mehdi Mirzaie Naser Ansari-Pour Jing Tang Mohieddin Jafari Studying relationships among gene products by expression profile analysis is a common approach in systems biology. Many studies have generalized the outcomes to the different levels of...
Wed Jun 03, 2020 03:00
Biomolecules, Vol. 10, Pages 849: A Ribosome Interaction Surface Sensitive to mRNA GCN Periodicity Biomolecules doi: 10.3390/biom10060849 Authors: Kristen Scopino Elliot Williams Abdelrahman Elsayed William A. Barr Daniel Krizanc Kelly M. Thayer Michael P. Weir A longstanding challenge is to understand how ribosomes parse mRNA open reading frames (ORFs). Significantly, GCN codons are over-represented in the initial codons of ORFs of prokaryote and eukaryote mRNAs. We...
Wed Jun 03, 2020 03:00
Biomolecules, Vol. 10, Pages 848: Cholinergic Stress Signals Accompany MicroRNA-Associated Stereotypic Behavior and Glutamatergic Neuromodulation in the Prefrontal Cortex Biomolecules doi: 10.3390/biom10060848 Authors: Gilli Moshitzky Shai Shoham Nimrod Madrer Amir Mouhammed Husain David S. Greenberg Raz Yirmiya Yoram Ben-Shaul Hermona Soreq Stereotypic behavior (SB) is common in emotional stress-involved psychiatric disorders and is often attributed to glutamatergic...
Wed Jun 03, 2020 03:00
Brain Sciences, Vol. 10, Pages 342: New Directions in Exercise Prescription: Is There a Role for Brain-Derived Parameters Obtained by Functional Near-Infrared Spectroscopy? Brain Sciences doi: 10.3390/brainsci10060342 Authors: Fabian Herold Thomas Gronwald Felix Scholkmann Hamoon Zohdi Dominik Wyser Notger G. Müller Dennis Hamacher In the literature, it is well established that regular physical exercise is a powerful strategy to promote brain health and to improve cognitive...
Wed Jun 03, 2020 03:00
Brain Sciences, Vol. 10, Pages 343: Dream Recall upon Awakening from Non-Rapid Eye Movement Sleep in Older Adults: Electrophysiological Pattern and Qualitative Features Brain Sciences doi: 10.3390/brainsci10060343 Authors: Serena Scarpelli Aurora D’Atri Chiara Bartolacci Maurizio Gorgoni Anastasia Mangiaruga Michele Ferrara Luigi De De Gennaro Several findings support the activation hypothesis, positing that cortical arousal promotes dream recall (DR). However, most...
Wed Jun 03, 2020 03:00
Brain Sciences, Vol. 10, Pages 344: Selected Ionotropic Receptors and Voltage-Gated Ion Channels: More Functional Competence for Human Induced Pluripotent Stem Cell (iPSC)-Derived Nociceptors Brain Sciences doi: 10.3390/brainsci10060344 Authors: Clemens L. Schoepf Maximilian Zeidler Lisa Spiecker Georg Kern Judith Lechner Kai K. Kummer Michaela Kress Preclinical research using different rodent model systems has largely contributed to the scientific progress in the pain...
Wed Jun 03, 2020 03:00
Brain Sciences, Vol. 10, Pages 341: Psychosocial and Behavioral Impact of COVID-19 in Autism Spectrum Disorder: An Online Parent Survey Brain Sciences doi: 10.3390/brainsci10060341 Authors: Marco Colizzi Elena Sironi Federico Antonini Marco Luigi Ciceri Chiara Bovo Leonardo Zoccante The 2019 coronavirus disease (COVID-19) outbreak could result in higher levels of psychological distress, especially among people suffering from pre-existing mental health conditions. Young...
Wed Jun 03, 2020 03:00
Brain Sciences, Vol. 10, Pages 340: Clinical Manifestation of Juvenile and Pediatric HD Patients: A Retrospective Case Series Brain Sciences doi: 10.3390/brainsci10060340 Authors: Jannis Achenbach Charlotte Thiels Thomas Lücke Carsten Saft Background: Studies on the clinical manifestation and course of disease in children suffering from Huntington’s disease (HD) are rare. Case reports of juvenile HD (onset ≤ 20 years) describe heterogeneous motoric and non-motoric...
Wed Jun 03, 2020 03:00
Brain Sciences, Vol. 10, Pages 339: Human Parvoviruses May Affect the Development and Clinical Course of Meningitis and Meningoencephalitis Brain Sciences doi: 10.3390/brainsci10060339 Authors: Anda Vilmane Anna Terentjeva Paulius L. Tamosiunas Normunds Suna Inga Suna Rasa Petraityte-Burneikiene Modra Murovska Santa Rasa-Dzelzkaleja Zaiga Nora-Krukle Meningitis and meningoencephalitis are neurological inflammatory diseases, and although routine diagnostics include...
Wed Jun 03, 2020 03:00
Cancers, Vol. 12, Pages 1456: HMGA Proteins in Hematological Malignancies Cancers doi: 10.3390/cancers12061456 Authors: Angela Minervini Nicoletta Coccaro Luisa Anelli Antonella Zagaria Giorgina Specchia Francesco Albano The high mobility group AT-Hook (HMGA) proteins are a family of nonhistone chromatin remodeling proteins known as “architectural transcriptional factors”. By binding the minor groove of AT-rich DNA sequences, they interact with the...
Wed Jun 03, 2020 03:00
Cancers, Vol. 12, Pages 1458: Challenges and Strategies in Ascribing Functions to Long Noncoding RNAs Cancers doi: 10.3390/cancers12061458 Authors: Yang Zhao Hongqi Teng Fan Yao Shannon Yap Yutong Sun Li Ma Long noncoding RNAs (lncRNAs) are involved in many physiological and pathological processes, such as development, aging, immunity, and cancer. Mechanistically, lncRNAs exert their functions through interaction with proteins, genomic DNA, and other RNA, leading to transcriptional...
Wed Jun 03, 2020 03:00
Cancers, Vol. 12, Pages 1455: Assessment of Liver Metastases Using CT and MRI Scans in Patients with Pancreatic Ductal Adenocarcinoma: Effects of Observer Experience on Diagnostic Accuracy Cancers doi: 10.3390/cancers12061455 Authors: Masakatsu Tsurusaki Isao Numoto Teruyoshi Oda Miyuki Wakana Ayako Suzuki Yukinobu Yagyu Mitsuru Matsuki Kazunari Ishii The aim of this study was to investigate the impact of radiologic experience on the diagnostic accuracy of computed...
Wed Jun 03, 2020 03:00
Cancers, Vol. 12, Pages 1457: Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions Cancers doi: 10.3390/cancers12061457 Authors: Maria Joana Catarata Ricardo Ribeiro Maria José Oliveira Carlos Robalo Cordeiro Rui Medeiros The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated...
Wed Jun 03, 2020 03:00
Cancers, Vol. 12, Pages 1454: Small Ones to Fight a Big Problem—Intervention of Cancer Metastasis by Small Molecules Cancers doi: 10.3390/cancers12061454 Authors: Dennis Kobelt Mathias Dahlmann Malti Dumbani Nazli Güllü Benedikt Kortüm Miguel E. Alberto Vílchez Ulrike Stein Wolfgang Walther Metastasis represents the most lethal attribute of cancer and critically limits successful therapies in many tumor entities. The clinical need is defined by the fact that all...
Wed Jun 03, 2020 03:00
Cancers, Vol. 12, Pages 1453: DSCAM-AS1-Driven Proliferation of Breast Cancer Cells Involves Regulation of Alternative Exon Splicing and 3′-End Usage Cancers doi: 10.3390/cancers12061453 Authors: Jamal Elhasnaoui Valentina Miano Giulio Ferrero Elena Doria Antonette E. Leon Aline S. C. Fabricio Laura Annaratone Isabella Castellano Anna Sapino Michele De Bortoli DSCAM-AS1 is a cancer-related long noncoding RNA with higher expression levels in Luminal A, B,...
Wed Jun 03, 2020 03:00
Cancers, Vol. 12, Pages 1459: Eupatilin Promotes Cell Death by Calcium Influx through ER-Mitochondria Axis with SERPINB11 Inhibition in Epithelial Ovarian Cancer Cancers doi: 10.3390/cancers12061459 Authors: Jin-Young Lee Hyocheol Bae Changwon Yang Sunwoo Park Byung-Soo Youn Han-Soo Kim Gwonhwa Song Whasun Lim Ovarian cancer is the leading cause of gynecological cancer-related mortality. The anticancer effect of eupatilin, a family of flavonoids, is known in many...
Wed Jun 03, 2020 03:00
Cancers, Vol. 12, Pages 1451: RKIP Regulates Differentiation-Related Features in Melanocytic Cells Cancers doi: 10.3390/cancers12061451 Authors: Cristina Penas Aintzane Apraiz Iraia Muñoa Yoana Arroyo-Berdugo Javier Rasero Pilar A. Ezkurra Veronica Velasco Nerea Subiran Anja K. Bosserhoff Santos Alonso Aintzane Asumendi Maria D. Boyano Raf Kinase Inhibitor Protein (RKIP) has been extensively reported as an inhibitor of key signaling pathways involved...
Wed Jun 03, 2020 03:00
Cancers, Vol. 12, Pages 1452: The Mechanical Microenvironment in Breast Cancer Cancers doi: 10.3390/cancers12061452 Authors: Stephen J.P. Pratt Rachel M. Lee Stuart S. Martin Mechanotransduction is the interpretation of physical cues by cells through mechanosensation mechanisms that elegantly translate mechanical stimuli into biochemical signaling pathways. While mechanical stress and their resulting cellular responses occur in normal physiologic contexts, there are a variety of...
Wed Jun 03, 2020 03:00
Cells, Vol. 9, Pages 1393: Sildenafil Recovers Burn-Induced Cardiomyopathy Cells doi: 10.3390/cells9061393 Authors: Jake J. Wen Claire Cummins Ravi S. Radhakrishnan Background: Severe burn injury initiates a feedback cycle of inflammation, fibrosis, oxidative stress and cardiac mitochondrial damage via the PDE5A-cGMP-PKG pathway. Aim: To test if the PDE5A-cGMP-PKG pathway may contribute to burn-induced heart dysfunction. Methods: Sprague–Dawley rats were divided four...
Wed Jun 03, 2020 03:00
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