Incidence and predictors of pericardial effusion after chemoradiation therapy for locally advanced non-small cell lung cancer

We investigated the incidence of and risk factors for pericardial effusion in patients with locally advanced non-small cell lung cancer in a prospective randomized controlled trial. Pericardial effusion occurred in nearly half of all patients even after moderate radiation doses to the heart. Adjuvant chemotherapy may increase the risk of pericardial effusion, and a cardiac V35 >10% may predict for the development of this toxicity

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